type: misc

label: url

en: Cricket: The third domesticated insect.

ja: Cricket: The third domesticated insect.

en: Many researchers are using crickets to conduct research on various topics related to development and regeneration in addition to brain function, behavior, and biological clocks, using advanced functional and perturbational technologies such as genome editing. Recently, crickets have also been attracting attention as a food source for the next generation of humans. In addition, crickets are increasingly being used as disease models and biological factories for pharmaceuticals. Cricket research has thus evolved over the last century from use primarily in highly important basic research, to use in a variety of applications and practical uses. These insects are now a state-of-the-art model animal that can be obtained and maintained in large quantities at low cost. We therefore suggest that crickets are useful as a third domesticated insect for scientific research, after honeybees and silkworms, contributing to the achievement of global sustainable development goals.

en: Current Topics in Developmental Biology

ja: Current Topics in Developmental Biology


en: Molecular mechanisms of insect metamorphosis: insights from studies of the cricket Gryllus bimaculatus

ja: 昆虫変態の分子機構:コオロギの研究から

en: 昆虫と自然

ja: 昆虫と自然


en: Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus

en: This review summarizes recent advances in leg regeneration research, focusing on the cricket Gryllus bimaculatus. Recent studies have revealed molecular mechanisms on blastema formation, establishment of positional information, and epigenetic regulation during leg regeneration. Especially, these studies have provided molecular bases in classical conceptual models such as the polar coordinate model, the intercalation model, the boundary model, the steepness model, etc., which were proposed to interpret regeneration processes of the cockroach legs. When a leg is amputated, a blastema is formed through the activation of the Janus-kinase (Jak)/Signal-Transduction-and-Activator-of-Transcription (STAT) pathway. Subsequently, the Hedgehog/Wingless/Decapentaplegic/Epidermal-growth-factor pathways instruct distalization in the blastema, designated as the molecular boundary model. Downstream targets of this pathway are transcription factors Distal-less (Dll) and dachshund (dac), functioning as key regulators of proximodistal pattern formation. Dll and dac specify the distal and proximal regions in the blastema, respectively, through the regulation of tarsal patterning genes. The expression of leg patterning genes during regeneration may be epigenetically controlled by histone H3K27 methylation via Enhancer-of-zeste and Ubiquitously-transcribed-tetratricopeptide-repeat-gene-X-chromosome. For the molecular mechanism of intercalation of the missing structures between the amputated position and the most distal one, Dachsous/Fat (Ds/Ft) steepness model has been proposed, in which the Ds/Ft pathway maintains positional information and determines leg size through dac expression. This model was theoretically verified to interpret the experimental results obtained with cricket legs. Availability of whole-genome sequence information, regeneration-dependent RNA interference, and genome editing technique will have the cricket be an ideal model system to reveal gene functions in leg regeneration.

en: The International Journal of Developmental Biology


en: Gene Knockout in the Cricket Using ZFN/TALEN

ja: ZFN/TALENを用いたコオロギの遺伝子ノックアウト

en: 細胞工学

ja: 細胞工学


en: 脚再生の分子メカニズム --- 再生芽誘導とサイズの決定について

ja: 脚再生の分子メカニズム --- 再生芽誘導とサイズの決定について

en: Experimental Medicine

ja: 実験医学


en: コオロギから学ぶ生物の発生システムの進化

ja: コオロギから学ぶ生物の発生システムの進化


en: 昆虫における初期発生システムの進化

ja: 昆虫における初期発生システムの進化

en: タンパク質核酸酵素

ja: タンパク質核酸酵素


en: ポストゲノム時代の形態学 システム形態学のテクノロジー

ja: ポストゲノム時代の形態学 システム形態学のテクノロジー

en: バイオテクノロジー ジャーナル

ja: バイオテクノロジー ジャーナル


en: 昆虫の体はどうやってできたか?

ja: 昆虫の体はどうやってできたか?

en: 遺伝

ja: 遺伝


en: 骨格筋形成におけるマイオスタチンの役割

ja: 骨格筋形成におけるマイオスタチンの役割

en: 生体の科学

ja: 生体の科学


en: 再生医学 --- 再生生物学から再生医学へ

ja: 再生医学 --- 再生生物学から再生医学へ

en: The Medical Frontline

ja: 最新医学


en: Functions of fibroblast growth factor and their receptors during morphogenesis

en: Tanpakushitsu Kakusan Koso

ja: Tanpakushitsu Kakusan Koso


en: 形態形成遺伝子の臨床利用をめざして

ja: 形態形成遺伝子の臨床利用をめざして

en: New Horizon for Medicine

ja: 現代医療


en: 発生·神経研究の最前線2000 --- 左右軸形成，神経幹細胞，器官再生を含む最新のトピックス


en: 線維芽細胞増殖因子(FGF)とその受容体の機能について

ja: 線維芽細胞増殖因子(FGF)とその受容体の機能について

en: 蛋白質 核酸 酵素

ja: 蛋白質 核酸 酵素


en: FGF-induced additional limbs in the study of initiation of limb formation, limb identity, myogenesis, and innervation

en: Cell and Tissue Research

ja: Cell and Tissue Research


en: 歯の発生の分子メカニズム

ja: 歯の発生の分子メカニズム

en: 基礎歯科医学会雑誌

ja: 基礎歯科医学会雑誌


en: FGFと形態形成

ja: FGFと形態形成


en: ホメオボックス遺伝子の機能

ja: ホメオボックス遺伝子の機能


en: 四肢形成の分子生物学的機序

ja: 四肢形成の分子生物学的機序

en: Clinical Calcium

ja: Clinical Calcium


en: 蛇足ではございますが

ja: 蛇足ではございますが

en: Infection, Inflammation & Immunity

ja: 感染·炎症·免疫


en: FGFによる肢の誘導とソニックヘッジホッグによる指の誘導

ja: FGFによる肢の誘導とソニックヘッジホッグによる指の誘導

en: Seikagaku

ja: 生化学


en: 位置情報を担うソニックヘッジホッグ

ja: 位置情報を担うソニックヘッジホッグ

en: Experimental Medicine


en: 眼の先天異常に関する原因遺伝子の解明

ja: 眼の先天異常に関する原因遺伝子の解明

en: 治療

ja: 治療


en: 眼の発生運命と分化方向の決定機構

ja: 眼の発生運命と分化方向の決定機構


en: Involvement of growth factors and their receptors in morphogenesis of the chick limb

en: Gann Monograph on Cancer Research

ja: Gann Monograph on Cancer Research


en: 発生分化におけるレチノイン酸の役割

ja: 発生分化におけるレチノイン酸の役割

en: The Cell

ja: 細胞


en: 細胞レベルのin situ hybridization法

ja: 細胞レベルのin situ hybridization法

en: Biomedica

ja: Biomedica