nojisumihare/published_papers/54122248 Shintaro Inoue Ayane Shimamura Kenichiro Koshiyama Sayuri Tomonari Taiyo Takada Yoshiyasu Ishimaru Katsuyuki Miyawaki Akira Takahashi Takeshi Nikawa Sumihare Noji Takahito Watanabe Taro Mito Gene misexpression system for functional studies of genes involved in cuticle development in the cricket Gryllus bimaculatus. The insect epidermis possesses the potential to generate remarkable diversity in exoskeletal cuticle traits, including colour, thickness and mechanical properties. Genetic manipulation is essential for investigating the molecular mechanisms; however, spatiotemporally controlled gene overexpression remains technically challenging despite the widespread use of loss-of-function approaches in many insects. In this study, we established an epidermal gene misexpression system in the model hemimetabolous insect Gryllus bimaculatus by inserting a gene expression cassette into the evolutionarily conserved yellow gene, which is involved in melanin synthesis, using genome editing. Insertion of the EGFP expression cassette into yellow gene resulted in fluorescence in the epidermis of pre-hatching embryos and post-moult individuals across developmental stages, corresponding to melanin pigmentation. Using this system, we induced the misexpression of Arylalkylamine N-acetyltransferase (aaNAT), an enzyme involved in the synthesis of N-acetyldopamine (NADA)-sclerotin, which serves as both a white pigment and a crosslinker in the cuticle. Compared to the background strain, the aaNAT misexpression strain exhibited a brighter body coloration, indicating that Gryllus aaNAT has the function of producing white NADA sclerotin and suppressing melanin pigment production. Wing thickness exhibited no substantial alteration, whereas a significant reduction in puncture resistance was observed. Collectively, these results suggest that an imbalance in the molecular components essential for cuticular crosslinking leads to alterations in the mechanical properties of the cuticle. This system serves as a gain-of-function analysis tool for cuticle research and has the potential to be applicable across a wide range of insect species, thereby helping to elucidate cuticle diversity. Insect molecular biology null null 20260517 10.1111/imb.70044 42144849 nojisumihare/published_papers/49346533 Kohei Kawamoto Yoshiyasu Ishimaru Sayuri Tomonari Takahito Watanabe Sumihare Noji Taro Mito Myoglianin is a crucial factor for the transition to the juvenile hormone-dependent phase during hemimetabolous nymphal development Elsevier BV Insect Biochemistry and Molecular Biology 0965-1748 178 104274 104274 20250300 10.1016/j.ibmb.2025.104274 nojisumihare/published_papers/52454947 Taketo Inoue Shintaro Inoue Yuhei Nogi Jun Tsukimoto Noriko Saito-Tarashima Sumihare Noji Taro Mito Noriaki Minakawa Development of a Gryllus bimaculatus-Based Assay System for Evaluating Chemically Modified siRNAs. Small interfering RNAs (siRNAs) hold great therapeutic promise due to their ability to selectively silence disease-associated genes. Although chemically modified siRNAs have demonstrated clinical efficacy, their development remains hindered by challenges such as stability and delivery under physiological conditions. Furthermore, in vitro screening of chemically modified siRNAs using cultured cells is cost-effective but often fails to recapitulate in vivo complexity, limiting predictive accuracy. To address this, we have developed a transfection-free siRNA evaluation platform using Gryllus bimaculatus (Gb), an insect model with natural RNA uptake capacity. We first demonstrated that 21-nucleotide siRNAs induced RNA interference upon abdominal injection under conditions of free uptake. We then generated transgenic lines harboring an EGFP reporter fused to the therapeutic siRNA target sequence and integrated into the β-actin locus via clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9-mediated knock-in. Two transgenic strains (s1 and d1) were established and validated. We compared unmodified and chemically modified siRNAs designed using enhanced stabilization chemistry (ESC), a clinically validated modification pattern incorporating 2'-O-methyl, 2'-fluoro, and phosphorothioate modifications. While ESC-modified siRNAs showed reduced activity compared to unmodified natural siRNAs in conventional cell-based assays requiring transfection reagents, they exhibited consistent gene silencing in Gb, reflecting their enhanced biochemical stability under free uptake conditions at picomole-scale doses. These results establish Gb as a scalable, cost-effective, and biologically relevant platform for evaluating therapeutic siRNAs, particularly those incorporating chemical modifications. Biological & pharmaceutical bulletin 48 6 941 950 20250000 10.1248/bpb.b25-00289 40582845 nojisumihare/published_papers/48681214 Shintaro Inoue Kai Fujie Taiki Hamaguchi Yoshiyasu Ishimaru Katsuyuki Miyawaki Akira Takahashi Takeshi Nikawa Sumihare Noji Takahito Watanabe Taro Mito Lineage-specific duplication and functional diversification of DOPA-decarboxylase genes in the Gryllidae family, as revealed in Gryllus bimaculatus. The DOPA-decarboxylase (DDC) gene is crucial for dopamine synthesis and influences various biological functions in insects, including body coloration, behavior, learning, and sleep. However, its evolutionary impact remains largely unexplored. This study reports on the tandem duplication of two bona fide ddc genes (ddc1 and ddc2) in the Gryllidae cricket family. We herein investigated the function of ddc1 and ddc2 using Gryllus bimaculatus (Gb) as a model. Our results revealed that Gb'ddc1 was expressed systemically, with its expression being higher immediately after molting compared to the stage following melanin pigmentation. In homozygous knockout mutants of Gb'ddc1, generated via CRISPR/Cas9, reduced body color pigmentation and had translucent cuticles, decreased dopamine levels, and over-accumulated DOPA. These mutants died shortly after hatching, likely due to cuticle defects, underscoring the essential role of dopamine, produced by Gb'ddc1, in melanin synthesis. Conversely, Gb'ddc2 expression was confined to the ovary and was not up-regulated after molting. Homozygous knockout mutants of Gb'ddc2 exhibited no body color defects, whereas hatchability and embryonic development rates were significantly reduced. Interestingly, dopamine levels in the ovaries were significantly elevated in Gb'ddc2 mutants. This suggests that normal ovarian dopamine levels, modulated by Gb'ddc2, are vital for fertility maintenance. The function of Gb'ddc2 differs from that of typical ddc, indicating neofunctionalization through evolutionary duplication. Overall, Gb'ddc1 and Gb'ddc2 have distinct functions, and precise regulation of ovarian dopamine levels using these two ddc genes may have enhanced cricket fertility. Insect biochemistry and molecular biology 104246 104246 20241207 10.1016/j.ibmb.2024.104246 39653316 nojisumihare/published_papers/43106094 Takahisa Yamashita Takahiro Ohde Taro Nakamura Yoshiyasu Ishimaru Takahito Watanabe Sayuri Tomonari Yuki Nakamura Sumihare Noji Taro Mito Involvement of the <i>scalloped</i> gene in morphogenesis of the wing margin via regulating cell growth in a hemimetabolous insect <i>Gryllus bimaculatus</i> Wiley Development, Growth &amp; Differentiation 1440-169X null null 20230623 10.1111/dgd.12869 nojisumihare/published_papers/42650352 Shintaro Inoue Takahito Watanabe Taiki Hamaguchi Yoshiyasu Ishimaru Katsuyuki Miyawaki Takeshi Nikawa Akira Takahashi Sumihare Noji Taro Mito Combinatorial expression of ebony and tan generates body color variation from nymph through adult stages in the cricket, Gryllus bimaculatus. Insect body colors and patterns change markedly during development in some species as they adapt to their surroundings. The contribution of melanin and sclerotin pigments, both of which are synthesized from dopamine, to cuticle tanning has been well studied. Nevertheless, little is known about how insects alter their body color patterns. To investigate this mechanism, the cricket Gryllus bimaculatus, whose body color patterns change during postembryonic development, was used as a model in this study. We focused on the ebony and tan genes, which encode enzymes that catalyze the synthesis and degradation, respectively, of the precursor of yellow sclerotin N-β-alanyl dopamine (NBAD). Expression of the G. bimaculatus (Gb) ebony and tan transcripts tended to be elevated just after hatching and the molting period. We found that dynamic alterations in the combined expression levels of Gb'ebony and Gb'tan correlated with the body color transition from the nymphal stages to the adult. The body color of Gb'ebony knockout mutants generated by CRISPR/Cas9 systemically darkened. Meanwhile, Gb'tan knockout mutants displayed a yellow color in certain areas and stages. The phenotypes of the Gb'ebony and Gb'tan mutants probably result from an over-production of melanin and yellow sclerotin NBAD, respectively. Overall, stage-specific body color patterns in the postembryonic stages of the cricket are governed by the combinatorial expression of Gb'ebony and Gb'tan. Our findings provide insights into the mechanism by which insects evolve adaptive body coloration at each developmental stage. PloS one 18 5 e0285934 null 20230000 10.1371/journal.pone.0285934 37200362 nojisumihare/published_papers/37822995 Yuki Nakamura Sayuri Tomonari Kohei Kawamoto Takahisa Yamashita Takahito Watanabe Yoshiyasu Ishimaru Sumihare Noji Taro Mito Evolutionarily conserved function of the even-skipped ortholog in insects revealed by gene knock-out analyses in Gryllus bimaculatus Elsevier BV Developmental Biology 0012-1606 485 1 8 20220500 10.1016/j.ydbio.2022.02.005 nojisumihare/published_papers/37862972 Taro Mito Yoshiyasu Ishimaru Takahito Watanabe Taro Nakamura Guillem Ylla Sumihare Noji Cassandra G Extavour Cricket: The third domesticated insect. Many researchers are using crickets to conduct research on various topics related to development and regeneration in addition to brain function, behavior, and biological clocks, using advanced functional and perturbational technologies such as genome editing. Recently, crickets have also been attracting attention as a food source for the next generation of humans. In addition, crickets are increasingly being used as disease models and biological factories for pharmaceuticals. Cricket research has thus evolved over the last century from use primarily in highly important basic research, to use in a variety of applications and practical uses. These insects are now a state-of-the-art model animal that can be obtained and maintained in large quantities at low cost. We therefore suggest that crickets are useful as a third domesticated insect for scientific research, after honeybees and silkworms, contributing to the achievement of global sustainable development goals. Current topics in developmental biology 147 291 306 20220000 10.1016/bs.ctdb.2022.02.003 35337452 nojisumihare/published_papers/35195224 Tetsuya Bando Misa Okumura Yuki Bando Marou Hagiwara Yoshimasa Hamada Yoshiyasu Ishimaru Taro Mito Eri Kawaguchi Takeshi Inoue Kiyokazu Agata Sumihare Noji Hideyo Ohuchi Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages Hemimetabolous insects, such as the two-spotted cricket Gryllus bimaculatus, can recover lost tissues in contrast to the limited regenerative abilities in human tissues. Following cricket leg amputation, the wound surface is covered by the wound epidermis, and plasmatocytes, which are insect macrophages, accumulate in the wound region. Here, we studied the function of Toll-related molecules identified by comparative RNA-seq during leg regeneration. Among 11 Toll genes in the Gryllus genome, expression of Gb'Toll2-1, Gb'Toll2-2, and Gb'Toll2-5 was upregulated during regeneration. RNA interference (RNAi) of Gb'Toll, Gb'Toll2-1, Gb'Toll2-2, Gb'Toll2-3, or Gb'Toll2-4 produced regeneration defects in more than 50% of crickets. RNAi of Gb'Toll2-2 decreased the ratios of S and M phase cells, expression of JAK/STAT signalling genes, and accumulation of plasmatocytes in the blastema. Depletion of plasmatocytes in crickets using clodronate also produced regeneration defects, along with reduced proliferating cells in the regenerating legs. Plasmatocyte depletion also downregulated the expression of Toll and JAK/STAT signalling genes in the regenerating legs. These results suggest that Spz-Toll-related signalling in plasmatocytes promotes leg regeneration through blastema cell proliferation by regulating the Upd-JAK/STAT signalling pathway. The Company of Biologists Development 1477-9129 null null 20211008 10.1242/dev.199916 nojisumihare/published_papers/34804643 Yuji Matsuoka Taro Nakamura Takahito Watanabe Austen A. Barnett Sumihare Noji Taro Mito Cassandra G. Extavour Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket Gryllus bimaculatus <title>Abstract</title>Studies of traditional model organisms like the fruit fly <italic>Drosophila melanogaster</italic> have contributed immensely to our understanding of the genetic basis of developmental processes. However, the generalizability of these findings cannot be confirmed without functional genetic analyses in additional organisms. Direct genome editing using targeted nucleases has the potential to transform hitherto poorly-understood organisms into viable laboratory organisms for functional genetic study. To this end, here we present a method to induce targeted genome knock-out and knock-in of desired sequences in an insect that serves as an informative contrast to <italic>Drosophila</italic>, the cricket <italic>Gryllus bimaculatus</italic>. The efficiency of germ line transmission of induced mutations is comparable to that reported for other well-studied laboratory organisms, and knock-ins targeting introns yields viable, fertile animals in which knock-in events are directly detectable by visualization of a fluorescent marker in the expression pattern of the targeted gene. Combined with the recently assembled and annotated genome of this cricket, this knock-in/knock-out method increases the viability of <italic>G. bimaculatus</italic> as a tractable system for functional genetics in a basally branching insect. Cold Spring Harbor Laboratory null null 20210510 10.1101/2021.05.10.441399 nojisumihare/published_papers/34804656 Guillem Ylla Taro Nakamura Takehiko Itoh Rei Kajitani Atsushi Toyoda Sayuri Tomonari Tetsuya Bando Yoshiyasu Ishimaru Takahito Watanabe Masao Fuketa Yuji Matsuoka Austen A. Barnett Sumihare Noji Taro Mito Cassandra G. Extavour Insights into the genomic evolution of insects from cricket genomes <title>Abstract</title>Most of our knowledge of insect genomes comes from Holometabolous species, which undergo the complete metamorphosis and have genomes under 2Gb with little signs of DNA methylation. In contrast, Hemiemetabolous insects undergo the ancestral incomplete metamorphosis and have larger genomes with high levels of DNA methylation. Hemimetabolous species from the Orthopteran order (grasshoppers and crickets) have some of the largest insect genomes. What drives the evolution of these unusual insect genome sizes, remains unknown. Here we report the sequencing, assembly and annotation of the 1.66-Gb genome of the Mediterranean field cricket <italic>Gryllus bimaculatus</italic>, and the annotation of the 1.60-Gb genome of the Hawaiian cricket <italic>Laupala kohalensis.</italic> We compare these two cricket genomes with those of 14 additional insects, and find evidence that hemimetabolous genomes expanded due to transposable element activity. Based on the ratio of observed to expected CpG sites, we find higher conservation and stronger purifying selection of methylated genes than non-methylated genes. Finally, our analysis suggests an expansion of the <italic>pickpocket</italic> class V gene family in crickets, which we speculate might play a role in the evolution of cricket courtship, including their characteristic chirping. Cold Spring Harbor Laboratory null null 20200707 10.1101/2020.07.07.191841 nojisumihare/published_papers/39566769 Taiki Miki Tsugumichi Shinohara Silvia Chafino Sumihare Noji Kenji Tomioka Photoperiod and temperature separately regulate nymphal development through JH and insulin/TOR signaling pathways in an insect Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America 117 10 5525 5531 20200310 10.1073/pnas.1922747117 nojisumihare/published_papers/26316015 Ishimaru Yoshiyasu 石丸 善康 Noji Sumihare 野地 澄晴 Miti Taro 三戸 太郎 Molecular mechanisms of insect metamorphosis: insights from studies of the cricket Gryllus bimaculatus 昆虫変態の分子機構:コオロギの研究から 昆虫と自然 54 11 38 41 20191000 nojisumihare/published_papers/26316013 Ishimaru Y Tomonari S Watanabe T Noji S Mito T Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 0962-8436 374 1783 20190225 null 20191000 10.1098/rstb.2019.0225 31438810 nojisumihare/published_papers/26743719 Mori Hiroyo Kawai Nobuhiko Kinouchi Nao Hichijo Natsuko Ishida Tatsuhiro Kawakami Emi Noji Sumihare Tanaka Eiji Effectiveness of cationic liposome-mediated local delivery of myostatin-targeting small interfering RNA in vivo (Retraction of Vol 56, Pg 223, 2014) DEVELOPMENT GROWTH & DIFFERENTIATION 0012-1592 61 6 389 null 20190800 10.1111/dgd.12583 nojisumihare/published_papers/25692820 Ishimaru Y Bando T Ohuchi H Noji S Mito T Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus. Development, growth & differentiation 0012-1592 60 6 377 386 20180800 10.1111/dgd.12560 30043459 nojisumihare/published_papers/25692808 Yasue A Kono H Habuta M Bando T Sato K Inoue J Oyadomari S Noji S Tanaka E Ohuchi H Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos. Scientific reports 7 1 53 null 20171200 10.1038/s41598-017-00088-w 28246397 nojisumihare/published_papers/26857458 Shigeo S. Sugano Hiroko Suzuki Eisuke Shimokita Hirofumi Chiba Sumihare Noji Yuriko Osakabe Keishi Osakabe Genome editing in the mushroom-forming basidiomycete Coprinopsis cinerea, optimized by a high-throughput transformation system SCIENTIFIC REPORTS 2045-2322 7 null null 20170400 10.1038/s41598-017-00883-5 28455526 nojisumihare/published_papers/29732238 Gerald S. Pollack Sumihare Noji History of cricket biology Springer Japan The Cricket as a Model Organism: Development, Regeneration, and Behavior 3 16 20170101 10.1007/978-4-431-56478-2_1 2-s2.0-85042822897 nojisumihare/published_papers/29717886 Hideyo Ohuchi Tetsuya Bando Taro Mito Sumihare Noji Eye development and photoreception of a hemimetabolous insect, gryllus bimaculatus Springer Japan The Cricket as a Model Organism: Development, Regeneration, and Behavior 49 62 20170101 10.1007/978-4-431-56478-2_4 2-s2.0-85033727997 nojisumihare/published_papers/29704096 Takahito Watanabe Sumihare Noji Taro Mito Genome editing in the cricket, Gryllus bimaculatus Humana Press Inc. Methods in Molecular Biology 1064-3745 1630 219 233 20170000 10.1007/978-1-4939-7128-2_18 28643262 2-s2.0-85021350879 nojisumihare/published_papers/25912304 Tetsuya Bando Yoshimasa Hamada Sumihare Noji Leg formation and regeneration The Cricket as a Model Organism: Development, Regeneration, and Behavior 31 48 20170101 10.1007/978-4-431-56478-2_3 2-s2.0-85042840739 nojisumihare/published_papers/28300916 Yasuko Kadomura-Ishikawa Katsuyuki Miyawaki Akira Takahashi Toshiya Masuda Sumihare Noji Light and abscisic acid independently regulated FaMYB10 in Fragaria x ananassa fruit PLANTA 1432-2048 241 4 953 965 20150400 10.1007/s00425-014-2228-6 nojisumihare/published_papers/26764078 Y Kadomura-Ishikawa Katsuyuki Miyawaki Akira Takahashi Toshiya Masuda Sumihare Noji Light and abscisic acid independently regulated FaMYB10 in Fragaria x ananassa fruit Light and ABA independently regulated anthocyanin biosynthesis via activation of FaMYB10 expression. FaMYB10 accelerated anthocyanin synthesis of pelargonidin 3-glucoside and cyanidin 3-glucoside during strawberry fruit ripening. Light is an integral factor in fruit ripening. Ripening in non-climacteric fruit is also effected by the plant hormone abscisic acid (ABA). However, how light and/or ABA regulate fruit ripening processes, such as strawberry color development remains elusive. Results of the present study showed light and ABA regulated strawberry fruit coloration via activation of FaMYB10 expression, an R2R3 MYB transcription factor. Light exposure increased FaMYB10 transcript levels, flavonoid pathway genes, and anthocyanin content. Exogenous ABA promoted FaMYB10 expression, and anthocyanin content, accompanied by increased ABA-responsive transcript levels and flavonoid pathway genes. ABA biosynthesis inhibitor treatment, and RNAi-mediated down-regulation of the ABA biosynthetic gene (9-cis epoxycarotenoid dioxygenase: FaNCED1), and ABA receptor (magnesium chelatase H subunit: FaCHLH/ABAR) showed inverse ABA effects. Furthermore, additive effects were observed in anthocyanin accumulation under combined light and ABA, indicating independent light and ABA signaling pathways. FaMYB10 down-regulation by Agrobacterium-mediated RNA interference (RNAi) in strawberry fruits showed decreased pelargonidin 3-glucoside and cyanidin 3-glucoside levels, accompanied by consistent flavonoid pathway gene expression levels. FaMYB10 over-expression showed opposite FaMYB10 RNAi phenotypes, particularly cyanidin 3-glucoside synthesis by FaMYB10, which was correlated with FaF3&#039;H transcript levels. These data provided evidence that light and ABA promoted FaMYB10 expression, resulting in anthocyanin accumulation via acceleration of flavonoid pathway gene expression. Finally, our results suggested FaMYB10 serves a role as a signal transduction mediator from light and ABA perception to anthocyanin synthesis in strawberry fruit. Planta 1432-2048 241 4 953 965 20150400 10.1007/s00425-014-2228-6 25534946 nojisumihare/published_papers/29650544 Katsuyuki Miyawaki Sumihare Noji Noriho Kamiya Transglutaminase-mediated in situ hybridization (transish) for mRNA detection in mammalian tissues Springer New York In Situ Hybridization Methods 549 558 20150218 10.1007/978-1-4939-2303-8_29 2-s2.0-84955398439 nojisumihare/published_papers/28067239 Takahito Watanabe Sumihare Noji Taro Mito Gene knockout by targeted mutagenesis in a hemimetabolous insect, the two-spotted cricket Gryllus bimaculatus, using TALENs METHODS 1095-9130 69 1 17 21 20140800 10.1016/j.ymeth.2014.05.006 nojisumihare/published_papers/25400840 Yasue, Akihiro Mitsui Silvia Naomi Watanabe, Takahito Sakuma, Tetsushi Oyadomari, Seiichi Yamamoto, Takashi Noji, Sumihare Mito, Taro Tanaka, Eiji Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems Since the establishment of embryonic stem (ES) cell lines, the combined use of gene targeting with homologous recombination has aided in elucidating the functions of various genes. However, the ES cell technique is inefficient and time-consuming. Recently, two new gene-targeting technologies have been developed: the transcription activator-like effector nuclease (TALEN) system, and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system. In addition to aiding researchers in solving conventional problems, these technologies can be used to induce site-specific mutations in various species for which ES cells have not been established. Here, by targeting the Fgf10 gene through RNA microinjection in one-cell mouse embryos with the TALEN and CRISPR/Cas systems, we produced the known limb-defect phenotypes of Fgf10-deficient embryos at the F0 generation. Compared to the TALEN system, the CRISPR/Cas system induced the limb-defect phenotypes with a strikingly higher efficiency. Our results demonstrate that although both gene-targeting technologies are useful, the CRISPR/Cas system more effectively elicits single-step biallelic mutations i NATURE PUBLISHING GROUP SCIENTIFIC REPORTS 2045-2322 4 null null 20140716 10.1038/srep05705 nojisumihare/published_papers/26743731 Hiroyo Mori Nobuhiko Kawai Nao Kinouchi Natsuko Hichijo Tatsuhiro Ishida Emi Kawakami Sumihare Noji Eiji Tanaka Effectiveness of cationic liposome- mediated local delivery of myostatin- targeting small interfering RNA in vivo DEVELOPMENT GROWTH & DIFFERENTIATION 1440-169X 56 3 223 232 20140400 10.1111/dgd.12123 24621004 nojisumihare/published_papers/25692824 Hiroshi Yoshida Tetsuya Bando Taro Mito Hideyo Ohuchi Sumihare Noji An extended steepness model for leg-size determination based on Dachsous/Fat trans- dimer system SCIENTIFIC REPORTS 2045-2322 4 4335 null 20140300 10.1038/srep04335 24613915 nojisumihare/published_papers/24903914 Yamashita T Ono K Ohuchi H Yumoto A Gotoh H Tomonari S Sakai K Fujita H Imamoto Y Noji S Nakamura K Shichida Y Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. The Journal of biological chemistry 0021-9258 289 7 3991 4000 20140200 10.1074/jbc.M113.514075 24403072 nojisumihare/published_papers/25622195 Jin QR Bando Y Miyawaki K Shikama Y Kosugi C Aki N Funaki M Noji S Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects. The journal of medical investigation : JMI 1343-1420 61 1-2 28 34 20140000 10.2152/jmi.61.28 24705745 nojisumihare/published_papers/29577132 Yasuko Kadomura-Ishikawa Katsuyuki Miyawaki Sumihare Noji Akira Takahashi Phototropin 2 is involved in blue light-induced anthocyanin accumulation in Fragaria x ananassa fruits Journal of Plant Research 0918-9440 126 6 847 857 20131100 10.1007/s10265-013-0582-2 23982948 2-s2.0-84886728151 nojisumihare/published_papers/26764080 Y Kadomura-Ishikawa Katsuyuki Miyawaki Sumihare Noji Akira Takahashi Phototropin 2 is involved in blue light-induced anthocyanin accumulation in Fragaria x ananassa fruits Anthocyanins are widespread, essential secondary metabolites in higher plants during color development in certain flowers and fruits. In strawberries, anthocyanins are also key contributors to fruit antioxidant capacity and nutritional value. However, the effects of different light qualities on anthocyanin accumulation in strawberry (Fragaria x ananassa, cv. Sachinoka) fruits remain elusive. In the present study, we showed the most efficient increase in anthocyanin content occurred by blue light irradiation. Light sensing at the molecular level was investigated by isolation of two phototropin (FaPHOT1 and FaPHOT2), two cryptochrome (FaCRY1 and FaCRY2), and two phytochrome (FaPHYA and FaPHYB) homologs. Expression analysis revealed only FaPHOT2 transcripts markedly increased depending on fruit developmental stage, and a corresponding increase in anthocyanin content was detected. FaPHOT2 knockdown resulted in decreased anthocyanin content; however, overexpression increased anthocyanin content. These findings suggested blue light induced anthocyanin accumulation, and FaPHOT2 may play a role in sensing blue light, and mediating anthocyanin biosynthesis in strawberry fruits. This is the first report to find a relationship between visible light sensing, and color development in strawberry fruits. Journal of Plant Research 1618-0860 126 6 847 857 20131100 10.1007/s10265-013-0582-2 23982948 nojisumihare/published_papers/25692810 Inoue J Ueda Y Bando T Mito T Noji S Ohuchi H The expression of LIM-homeobox genes, Lhx1 and Lhx5, in the forebrain is essential for neural retina differentiation. Development, growth & differentiation 0012-1592 55 7 668 675 20130900 10.1111/dgd.12074 24024588 nojisumihare/published_papers/25692781 Bando T Ishimaru Y Kida T Hamada Y Matsuoka Y Nakamura T Ohuchi H Noji S Mito T Analysis of RNA-Seq data reveals involvement of JAK/STAT signalling during leg regeneration in the cricket Gryllus bimaculatus. 5 Development (Cambridge, England) 0950-1991 140 959 964 20130300 10.1242/dev.084590 23344706 nojisumihare/published_papers/25857229 Kawakami E Kawai N Kinouchi N Mori H Ohsawa Y Ishimaru N Sunada Y Noji S Tanaka E Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function. PloS one 8 5 e64719 null 20130000 10.1371/journal.pone.0064719 23717655 nojisumihare/published_papers/25692791 Kawaue T Okamoto M Matsuyo A Inoue J Ueda Y Tomonari S Noji S Ohuchi H Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken. 11 Biology open 1 1083 1093 20121100 10.1242/bio.20121396 23213388 nojisumihare/published_papers/27173277 Yutaka Ohsawa Tadashi Okada Shin-ichiro Nishimatsu Masatoshi Ishizaki Tomohiro Suga Masahiro Fujino Tatsufumi Murakami Makoto Uchino Kunihiro Tsuchida Sumihare Noji Atsushi Hinohara Toshiyuki Shimizu Kiyoshi Shimizu Yoshihide Sunada An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy LABORATORY INVESTIGATION 0023-6837 92 8 1100 1114 20120800 10.1038/labinvest.2012.78 nojisumihare/published_papers/25335859 Takagi Akira Kurita Kazuki Terasawa Taiki Nakamura Taro Bando Tetsuya Moriyama Yoshiyuki Mito Taro Noji Sumihare Ohuchi Hideyo Functional analysis of the role of <I>eyes absent</I> and <I>sine oculis</I> in the developing eye of the cricket <I>Gryllus bimaculatus.</I> Development, Growth & Differentiation 0012-1592 54 2 227-240 null 20120200 nojisumihare/published_papers/28619080 Katsuyuki Miyawaki Sachi Fukuoka Yasuko Kadomura Hirokazu Hamaoka Taro Mito Hideyo Ohuchi Wilfried Schwab Sumihare Noji Establishment of a novel system to elucidate the mechanisms underlying light-induced ripening of strawberry fruit with an Agrobacterium-mediated RNAi technique PLANT BIOTECHNOLOGY 1342-4580 29 3 271 277 20120000 10.5511/plantbiotechnology.12.0406a nojisumihare/published_papers/25687029 Ohuchi H Yamashita T Tomonari S Fujita-Yanagibayashi S Sakai K Noji S Shichida Y A non-mammalian type opsin 5 functions dually in the photoreceptive and non-photoreceptive organs of birds. PloS one 7 2 e31534 null 20120000 10.1371/journal.pone.0031534 22348098 nojisumihare/published_papers/25400847 Watanabe T Ochiai H Sakuma T Horch HW Hamaguchi N Nakamura T Bando T Ohuchi H Yamamoto T Noji S Mito T Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases Nat Commun null null 20120000 nojisumihare/published_papers/52312838 川上 恵実 田中 栄二 砂田 芳秀 土田 邦博 野地 澄晴 特集 筋ジストロフィーの分子病態から治療へ マイオスタチンの発現抑制による治療 株式会社医学書院 生体の科学 1883-5503 62 2 146 150 20110415 10.11477/mf.2425101129 1390845702319870592 nojisumihare/published_papers/29829789 Seiichi Koike Yoshifumi Yutoh Kazuko Keino-Masu Sumihare Noji Masayuki Masu Hideyo Ohuchi Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development Developmental Dynamics 1058-8388 240 2 413 421 20110200 10.1002/dvdy.22543 21246658 2-s2.0-78751522898 nojisumihare/published_papers/52333263 Kadomura Yasuko 角村 寧子 Miyawaki Katsuyuki 宮脇 克行 Hamaoka Hirokazu 浜岡 宏和 Takahashi Akira 高橋 章 Noji Sumihare 野地 澄晴 Functional analyses of photoreceptors in anthocyanin biosynthesis pathway of the strawberry (cv. Sachinoka) イチゴの着色過程における光受容体の役割と解析 In <I>Arabidopsis</I>, UV and blue light stimulate expression of anthocyanin biosynthesis gene. In the strawberry <I>Fragaria ananassa</I>, UV light increases the red coloration in receptacle, whereas the effect of blue light or other wavelength is not reported yet. In this study, we examined the effect of irradiation on the red coloration of strawberry (cv. Sachinoka) by using various wavelength of LED. 24 h after irradiation of LED and incubated for 36 h in darkness, we measured anthocyanin content. As a result, 465 nm of blue LED irradiated fruits increased 3-fold amount of anthocyanin than green LED (525 nm) or red LED (625 nm) irradiation.<br> In addition, we examined functional analysis of blue light photoreceptor genes, <I>phototropin</I> (<I>phot</I>) and <I>cryptochrome</I> (<I>cry</I>), by agrobacterium-mediated RNA interference (RNAi). We observed the reduction of red color in the epidermis and the internal region of receptacle in the RNAi fruits compared with control fruits. We found that anthocyanin content in the RNAi fruits was lower than controls (control 100%, <I>phot</I> 56%, <I>cry</I> 45%). <br> These results indicate that both photoreceptors may be involved in anthocyanin biosynthesis pathway in the strawberry fruit. シロイヌナズナにおいてアントシアニン生合成に関連する遺伝子発現に有効な光質はUV-B，UV-Aおよび青色光であることが報告されている．イチゴ花托の着色はUVで促進されることは報告されているが，青色光またはそれ以外の光質の役割はまだわかっていない．本研究では，イチゴ着色における光受容体遺伝子の機能解析のために，さちのか(<I>Fragaria ananassa</I>)の赤く色づく前の白い花托にLEDを照射し，イチゴ花托への着色効果を解析した．LEDを24時間照射後，暗黒に36時間放置し，アントシアニン含量を定量した結果，青色LED(465 nm)を照射した花托では，緑色(525 nm)，赤色(625 nm)照射と比較して，3倍以上増加した．<br> また，アグロバクテリウムを介したRNAi法を用いて，青色光受容体遺伝子 (<I>phototropin</I>, <I>cryptochrome</I>) の機能解析を行ったところ，全体的に赤色を呈するコントロールと比較して，表皮および内部の着色の低下が観察でされ，RNAi花托のアントシアニン含量は低下(<I>phot</I> RNAi 約56%，<I>cry</I> RNAi 約45%)していることがわかった．<br> 以上のことから，イチゴ花托において，青色光の照射により着色が促進され，青色光受容体の機能を抑制すると着色が低下したことから，青色光受容体がアントシアニン生合成に関与していることが示唆された． The Japanese Society of Plant Physiologists 日本植物生理学会 Plant and Cell Physiology Supplement 日本植物生理学会年会およびシンポジウム 講演要旨集 2011 0803 0803 20110000 10.14841/jspp.2011.0.0803.0 1390001205635894144 nojisumihare/published_papers/29031193 Yoshiyuki Moriyama Tomoaki Sakamoto Akira Matsumoto Sumihare Noji Kenji Tomioka Functional analysis of the circadian clock gene period by RNA interference in nymphal crickets Gryllus bimaculatus JOURNAL OF INSECT PHYSIOLOGY 1879-1611 55 2 183 187 20090200 10.1016/j.jinsphys.2008.11.005 nojisumihare/published_papers/29834425 Taro Mito Sumihare Noji The two-spotted cricket Gryllus bimaculatus: An emerging model for developmental and regeneration studies Cold Spring Harbor Protocols 1559-6095 3 12 null null 20081200 10.1101/pdb.emo110 2-s2.0-79954588899 nojisumihare/published_papers/25233862 Urasaki, A Mito, T Noji, S Ueda, R Kawakami, K Transposition of the vertebrate Tol2 transposable element in Drosophila melanogaster. 国立遺伝学研究所以外の共著者あり Gene 0378-1119 425 1-2 64 68 20081200 10.1016/j.gene.2008.08.008 18775483 nojisumihare/published_papers/25673714 Kinouchi N Ohsawa Y Ishimaru N Ohuchi H Sunada Y Hayashi Y Tanimoto Y Moriyama K Noji S Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass. RNA interference (RNAi) offers a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. Since it relies on small interfering RNAs (siRNAs), a major issue is the delivery of therapeutically active siRNAs into the target tissue/target cells in vivo. For safety reasons, strategies based on vector delivery may be of only limited clinical use. The more desirable approach is to directly apply active siRNAs in vivo. Here, we report the effectiveness of in vivo siRNA delivery into skeletal muscles of normal or diseased mice through nanoparticle formation of chemically unmodified siRNAs with atelocollagen (ATCOL). ATCOL-mediated local application of siRNA targeting myostatin, a negative regulator of skeletal muscle growth, in mouse skeletal muscles or intravenously, caused a marked increase in the muscle mass within a few weeks after application. These results imply that ATCOL-mediated application of siRNAs is a powerful tool for future therapeutic use for diseases including muscular atrophy. Gene Therapy 0969-7128 15 15 1126 1130 20080800 10.1038/gt.2008.24 18323791 nojisumihare/published_papers/24996222 Yoshiyuki Moriyama Moriyama Y Tomoaki Sakamoto Sakamoto T Svetlana G Karpova Karpova S.G Akira Matsumoto Matsumoto A Sumihare Noji Noji S Kenji Tomioka Tomioka K RNA interference of the clock gene period disrupts circadian rhythms in the cricket Gryllus bimaculatus. Periodic expression of so-called clock genes is an essential part of the circadian clock. In Drosophila melanogaster the cyclic expression of per and tim through an autoregulatory feedback loop is believed to play a central role in circadian rhythm generation. However, it is still elusive whether this hypothesis is applicable to other insect species. Here it is shown that per gene plays a key role in the rhythm generation in the cricket Gryllus bimaculatus. Measurement of per mRNA levels in the optic lobe revealed the rhythmic expression of per in light cycles with a peak in the late day to early night, persisting in constant darkness. A single injection of per double-stranded RNA (dsRNA) into the abdomen of the final instar nymphs effectively knocked down the mRNA levels as adult to about 50% of control animals. Most of the per dsRNA-injected crickets completely lost the circadian locomotor activity rhythm in constant darkness up to 50 days after the injection, whereas those injected with DsRed2 dsRNA as a negative control clearly maintained it. The electrical activity of optic lobe efferents also became arrhythmic in the per dsRNA-injected crickets. These results not only suggest that per plays an important role in the circadian rhythm generation also in the cricket but also show that RNA interference is a powerful tool to dissect the molecular machinery of the cricket circadian clock. Journal of biological rhythms J. Biol. Rhythms 23 4 308 18 20080800 10.1177/0748730408320486 18663238 nojisumihare/published_papers/25692788 Nakamura T Mito T Miyawaki K Ohuchi H Noji S EGFR signaling is required for re-establishing the proximodistal axis during distal leg regeneration in the cricket Gryllus bimaculatus nymph. 1 Developmental biology 0012-1606 319 1 46 55 20080701 10.1016/j.ydbio.2008.04.002 18486122 nojisumihare/published_papers/25692787 Mito T Nakamura T Sarashina I Chang CC Ogawa S Ohuchi H Noji S Dynamic expression patterns of vasa during embryogenesis in the cricket Gryllus bimaculatus. 7 Development genes and evolution 0949-944X 218 7 381 387 20080700 10.1007/s00427-008-0226-z 18542998 nojisumihare/published_papers/25692786 Tomonari S Migita K Takagi A Noji S Ohuchi H Expression patterns of the opsin 5-related genes in the developing chicken retina. 7 Developmental dynamics : an official publication of the American Association of Anatomists 1058-8388 237 1910 1922 20080700 10.1002/dvdy.21611 18570255 nojisumihare/published_papers/25692789 Okamoto M Tomonari S Naito Y Saigo K Noji S Ui-Tei K Ohuchi H Introduction of silencing-inducing transgene against Fgf19 does not affect expression of Tbx5 and beta3-tubulin in the developing chicken retina. 3 Development, growth & differentiation 0012-1592 50 159 168 20080300 10.1111/j.1440-169X.2008.00996.x 18312426 nojisumihare/published_papers/29158774 Masashi Nakatani Yuka Takehara Hiromu Sugino Mitsuru Matsumoto Osamu Hashimoto Yoshihisa Hasegawa Tatsuya Murakami Akiyoshi Uezumi Shin'ichi Takeda Sumihare Noji Yoshihide Sunada Kunihiro Tsuchida Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice FASEB JOURNAL 0892-6638 22 2 477 487 20080200 10.1096/fj.07-8673com nojisumihare/published_papers/29120112 Monica Ronco Tomohiro Uda Taro Mito Alessandro Minelli Sumihare Noji Martin Klingler Antenna and all gnathal appendages are similarly transformed by homothorax knock-down in the cricket Gryllus bimaculatus DEVELOPMENTAL BIOLOGY 0012-1606 313 1 80 92 20080100 10.1016/j.ydbio.2007.09.059 nojisumihare/published_papers/26890774 Yutaka Ohsawa Tadashi Okada Atsushi Kuga Saori Hayashi Tatsufumi Murakami Kunihiro Tsuchida Sumihare Noji Yoshihide Sunada Caveolin-3 regulates myostatin signaling. Mini-review Acta Myologica. 27 19 24 20080000 nojisumihare/published_papers/25692790 Mito T Ronco M Uda T Nakamura T Ohuchi H Noji S Divergent and conserved roles of extradenticle in body segmentation and appendage formation, respectively, in the cricket Gryllus bimaculatus. 1 Developmental biology 0012-1606 313 1 67 79 20080101 10.1016/j.ydbio.2007.09.060 18036518 nojisumihare/published_papers/28794514 Masayuki Mitsumori Taro Adachi Kazuho Takayanagi Taro Mito Hideyo Ohuchi Shouichi Kimura Mitsunori Kokubo Toshiro Higuchi Sumihare Noji Film tomography as a tool for three-dimensional image construction and gene expression studies DEVELOPMENT GROWTH & DIFFERENTIATION 0012-1592 49 7 583 589 20070900 nojisumihare/published_papers/25673731 Nishi M Yasue A Kinouchi N Noji S Moriyama K The increases in the skeletal muscle mass of the transgenic mice expressing the mutated myostatin affected craniofacial morphology. Orthodontic Waves 1344-0241 66 3 73 78 20070900 10.1016/j.odw.2007.05.001 nojisumihare/published_papers/25692796 Tomonari S Takagi A Noji S Ohuchi H Expression pattern of the melanopsin-like (cOpn4m) and VA opsin-like genes in the developing chicken retina and neural tissues. 7 Gene expression patterns : GEP 1567-133X 7 746 753 20070800 10.1016/j.modgep.2007.06.001 17631423 nojisumihare/published_papers/25360896 Takehara-Kasamatsu Y Tsuchida K Nakatani M Murakami T Kurisaki A Hashimoto O Ohuchi H Kurose H Mori K Kagami S Noji S Sugino H Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development The journal of medical investigation : JMI 1349-6867 54 3,4 276 288 20070800 10.2152/jmi.54.276 nojisumihare/published_papers/28785428 Kuniko Mizuta Satoshi Tsutsumi Hiroshi Inoue Yukiko Sakamoto Katsutoshi Miyatake Katsuyuki Miyawaki Sumihare Noji Nobuyuki Kamata Mitsuo Itakura Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 357 1 126 132 20070500 10.1016/j.bbrc.2007.03.108 nojisumihare/published_papers/28771095 Kai Sun Zheyu Li Kosei Ueno Saulius Juodkazis Sumihare Noji Hiroaki Misawa Electrophoretic chip for high-fidelity fractionation of double-stranded DNA ELECTROPHORESIS 0173-0835 28 10 1572 1578 20070500 10.1002/elps.200600685 nojisumihare/published_papers/25287412 Ohuchi Hideyo Hayashibara Yasunori Matsuda Hironao Onoi Motoyoshi Mitsumori Masayuki Tanaka Masayuki Aoki Junken Arai Hiroyuki Noji Sumihare Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development (vol 236, pg 1134, 2007) DEVELOPMENTAL DYNAMICS 1058-8388 236 5 1376 null 20070500 10.1002/dvdy.21158 nojisumihare/published_papers/25287414 Ohuchi Hideyo Hayashibaral Yasunori Matsuda Hironao Onoi Motoyoshi Mitsumori Masayuki Tanaka Masayuki Aoki Junken Arai Hiroyuki Noji Sumihare Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development DEVELOPMENTAL DYNAMICS 1058-8388 236 4 1134 1143 20070400 10.1002/dvdy.21119 nojisumihare/published_papers/25870464 Mito T Kobayashi C Sarashina I Zhang H Shinahara W Miyawaki K Shinmyo Y Ohuchi H Noji S even-skipped has gap-like, pair-rule-like, and segmental functions in the cricket Gryllus bimaculatus, a basal, intermediate germ insect (Orthoptera). Developmental biology 0012-1606 303 1 202 213 20070300 10.1016/j.ydbio.2006.11.003 17174947 nojisumihare/published_papers/28786539 Taro Nakamura Taro Mito Yoshihisa Tanaka Tetsuya Bando Hideyo Ohuchi Sumihare Noji Involvement of canonical Wnt/Wingless signaling in the determination of the positional values within the leg segment of the cricket Gryllus bimaculatus DEVELOPMENT GROWTH & DIFFERENTIATION 0012-1592 49 2 79 88 20070200 10.1111/j.1440-169x.2007.00915.x nojisumihare/published_papers/29765254 Taro Mito Sumihare Noji Evolution of developmental systems underlying segmented body plans of bilaterian animals: Insights from studies of segmentation in a cricket Palaeontological Society of Japan Paleontological Research 1342-8144 10 4 337 344 20061231 10.2517/prpsj.10.337 2-s2.0-33846850562 nojisumihare/published_papers/25870466 Shinmyo Y Mito T Uda T Nakamura T Miyawaki K Ohuchi H Noji S brachyenteron is necessary for morphogenesis of the posterior gut but not for anteroposterior axial elongation from the posterior growth zone in the intermediate-germband cricket Gryllus bimaculatus. Development (Cambridge, England) 0950-1991 133 22 4539 4547 20061100 10.1242/dev.02646 17050622 nojisumihare/published_papers/25370076 Ohsawa Y Hagiwara H Nakatani M Yasue A Moriyama K Murakami T Tsuchida K Noji S Sunada Y Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. 11 The Journal of clinical investigation 0021-9738 116 2924 2934 20061100 10.1172/JCI28520 17039257 nojisumihare/published_papers/25286692 Tanaka M Okudaira S Kishi Y Ohkawa R Iseki S Ota M Noji S Yatomi Y Aoki J Arai H Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. The Journal of biological chemistry 0021-9258 281 35 25822 25830 20060900 10.1074/jbc.M605142200 16829511 nojisumihare/published_papers/27561782 Yoshihide Sunada Yutaka Ohsawa Hiroki Hagiwara Tatsufumi Murakami Kunihiro Tsuchida Sumihare Noji Regulation of myostatin signaling by caveolin-3 NEUROMUSCULAR DISORDERS 0960-8966 16 S56 S57 20060700 nojisumihare/published_papers/29754660 Masahiro Shin Sumihare Noji Annette Neubüser Sadao Yasugi FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo Academic Press Inc. Developmental Biology 0012-1606 294 1 11 23 20060601 10.1016/j.ydbio.2005.12.019 16616737 2-s2.0-33645989377 nojisumihare/published_papers/25870468 Mito T Okamoto H Shinahara W Shinmyo Y Miyawaki K Ohuchi H Noji S Krüppel acts as a gap gene regulating expression of hunchback and even-skipped in the intermediate germ cricket Gryllus bimaculatus. Developmental biology 0012-1606 294 2 471 481 20060600 10.1016/j.ydbio.2005.12.057 16616119 nojisumihare/published_papers/25692797 Tao H Ono K Kurose H Noji S Ohuchi H Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFalpha-EGFR signaling. 5 Development, growth & differentiation 0012-1592 48 5 339 346 20060600 10.1111/j.1440-169X.2006.00869.x 16759284 nojisumihare/published_papers/25971609 和田直之 濃野勉 野地澄晴 四肢骨格パターン形成におけるBMPの機能 Clinical Calcium 16 5 53 60 20060500 nojisumihare/published_papers/29749144 Michio Ogasawara Nori Satoh Yasuhito Shimada Zhipeng Wang Toshio Tanaka Sumihare Noji Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses Development Genes and Evolution 0949-944X 216 2 100 104 20060200 10.1007/s00427-005-0031-x 16249872 2-s2.0-32044465557 nojisumihare/published_papers/26806445 Yoshimura A Nakata A Mito T Noji S The characteristics of karyotype and telomeric satellite DNA sequences in the cricket, Gryllus bimaculatus (Orthoptera, Gryllidae). Cytogenetic and genome research 1424-8581 112 3-4 329 336 20060000 10.1159/000089889 16484791 nojisumihare/published_papers/48460890 大澤 裕 萩原 宏毅 土田 邦博 野地 澄晴 武田 伸一 篠野 静香 森 弥生 村上 龍文 砂田 芳秀 ミオスタチンプロドメインによる変異カベオリン3トランスジェニックマウス表現型改善 (一社)日本神経学会 臨床神経学 1882-0654 45 12 1196 1196 20051200 nojisumihare/published_papers/25692798 Tomonari S Takagi A Akamatsu S Noji S Ohuchi H A non-canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina. 3 Developmental dynamics : an official publication of the American Association of Anatomists 1058-8388 234 783 790 20051100 10.1002/dvdy.20600 16217736 nojisumihare/published_papers/52915278 T Yamaai T Nakanishi M Asano K Nawachi G Yoshimichi K Ohyama T Komori T Sugimoto M Takigawa Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development JOURNAL OF BONE AND MINERAL METABOLISM 0914-8779 23 4 280 288 20050700 10.1007/s00774-004-0600-5 15981023 nojisumihare/published_papers/25692799 Tao H Shimizu M Kusumoto R Ono K Noji S Ohuchi H A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. 14 Development (Cambridge, England) 0950-1991 132 14 3217 3230 20050700 10.1242/dev.01892 15958512 nojisumihare/published_papers/52997513 T Narita S Sasaoka K Udagawa T Ohyama N Wada S Nishimatsu S Takada T Nohno Wnt10a is involved in AER formation during chick limb development DEVELOPMENTAL DYNAMICS 1058-8388 233 2 282 287 20050600 10.1002/dvdy.20321 nojisumihare/published_papers/25870470 Mito T Sarashina I Zhang H Iwahashi A Okamoto H Miyawaki K Shinmyo Y Ohuchi H Noji S Non-canonical functions of hunchback in segment patterning of the intermediate germ cricket Gryllus bimaculatus. Development (Cambridge, England) 0950-1991 132 9 2069 2079 20050500 10.1242/dev.01784 15788457 nojisumihare/published_papers/25692801 Kurose H Okamoto M Shimizu M Bito T Marcelle C Noji S Ohuchi H FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo. 4 Development, growth & differentiation 0012-1592 47 4 213 223 20050500 10.1111/j.1440-169X.2005.00795.x 15921496 nojisumihare/published_papers/25673811 Ohuchi H Yasue A Ono K Sasaoka S Tomonari S Takagi A Itakura M Moriyama K Noji S Nohno T Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev Dyn 233 1 177 187 20050500 10.1002/dvdy.20319 15765517 nojisumihare/published_papers/25870474 Zhang H Shinmyo Y Mito T Miyawaki K Sarashina I Ohuchi H Noji S Expression patterns of the homeotic genes Scr, Antp, Ubx, and abd-A during embryogenesis of the cricket Gryllus bimaculatus. Gene expression patterns : GEP 1567-133X 5 4 491 502 20050400 10.1016/j.modgep.2004.12.006 15749077 nojisumihare/published_papers/25870477 Shinmyo Y Mito T Matsushita T Sarashina I Miyawaki K Ohuchi H Noji S caudal is required for gnathal and thoracic patterning and for posterior elongation in the intermediate-germband cricket Gryllus bimaculatus. Mechanisms of development 0925-4773 122 2 231 239 20050200 10.1016/j.mod.2004.10.001 15652710 nojisumihare/published_papers/25870472 Sarashina I Mito T Saito M Uneme H Miyawaki K Shinmyo Y Ohuchi H Noji S Location of micropyles and early embryonic development of the two-spotted cricket Gryllus bimaculatus (Insecta, Orthoptera). Development, growth & differentiation 0012-1592 47 2 99 108 20050200 10.1111/j.1440-169x.2005.00786.x 15771629 nojisumihare/published_papers/29706746 Hiroyuki Iwahana Morisada Hayakawa Kenji Kuroiwa Kenji Tago Ken Yanagisawa Sumihare Noji Shin-Ichi Tominaga Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV Biochimica et Biophysica Acta - Gene Structure and Expression 0167-4781 1681 1 1 14 20041124 10.1016/j.bbaexp.2004.08.013 15566939 2-s2.0-9244222725 nojisumihare/published_papers/25673832 西 真寿美 泰江 章博 木内 奈央 野地 澄晴 森山 啓司 マイオスタチン突然変異による骨格筋量増加がマウス下顎骨形態に及ぼす影響 (公社)日本矯正歯科学会 日本矯正歯科学会大会プログラム・抄録集 63 190 190 20041100 nojisumihare/published_papers/25870479 Inoue Y Miyawaki K Terasawa T Matsushima K Shinmyo Y Niwa N Mito T Ohuchi H Noji S Expression patterns of dachshund during head development of Gryllus bimaculatus (cricket). Gene expression patterns : GEP 1567-133X 4 6 725 731 20041000 10.1016/j.modgep.2004.03.010 15465496 nojisumihare/published_papers/25692802 Kurose H Bito T Adachi T Shimizu M Noji S Ohuchi H Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. 6 Gene expression patterns : GEP 1567-133X 4 687 693 20041000 10.1016/j.modgep.2004.04.005 15465490 nojisumihare/published_papers/26353492 Hagiwara H Ohsawa Y Sasano S Yasue A Noji S Sunada Y Skeletal muscle hyperplasia in the transgenic mice overexpressing the myostatin prodomain Neuromuscular disorders : NMD 0960-8966 14 8-9 610 null 20040900 nojisumihare/published_papers/25870481 Shinmyo Y Mito T Matsushita T Sarashina I Miyawaki K Ohuchi H Noji S piggyBac-mediated somatic transformation of the two-spotted cricket, Gryllus bimaculatus. Development, growth & differentiation 0012-1592 46 4 343 349 20040800 10.1111/j.1440-169x.2004.00751.x 15367202 nojisumihare/published_papers/29696430 Masumi Nishi Akihiro Yasue Shinichirou Nishimatu Tsutomu Nohno Takashi Yamaoka Mitsuo Itakura Keiji Moriyama Hideyo Ohuchi Sumihare Noji Erratum: A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle (Biochemical and Biophysical Research Communications (2002) 293 (247-251) DOI: 10.1016/S0006-291X(02)00209-7) Biochemical and Biophysical Research Communications 0006-291X 318 3 801 null 20040604 10.1016/j.bbrc.2004.04.091 2-s2.0-2442562565 nojisumihare/published_papers/28508150 M Sugihara T Matsuo Recent developments of the Sinc numerical methods JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS 1879-1778 164 673 689 20040300 10.1016/j.cam.2003.09.016 nojisumihare/published_papers/25870483 Miyawaki K Mito T Sarashina I Zhang H Shinmyo Y Ohuchi H Noji S Involvement of Wingless/Armadillo signaling in the posterior sequential segmentation in the cricket, Gryllus bimaculatus (Orthoptera), as revealed by RNAi analysis. Mechanisms of development 0925-4773 121 2 119 130 20040200 10.1016/j.mod.2004.01.002 15037314 nojisumihare/published_papers/27752075 西 真寿美 泰江 章博 土田 邦博 野地 澄晴 森山 啓司 骨格筋形成に関わるマイオスタチンのシグナル伝達経路の解析 (公社)日本矯正歯科学会 日本矯正歯科学会大会プログラム・抄録集 62 212 212 20031000 nojisumihare/published_papers/25870485 Sarashina I Shinmyo Y Hirose A Miyawaki K Mito T Ohuchi H Horio T Noji S Hypotonic buffer induces meiosis and formation of anucleate cytoplasmic islands in the egg of the two-spotted cricket Gryllus bimaculatus. Development, growth & differentiation 0012-1592 45 2 103 112 20030400 10.1034/j.1600-0854.2004.00679.x 12752498 nojisumihare/published_papers/25692803 Ohuchi H Tao H Ohata K Itoh N Kato S Noji S Ono K Fibroblast growth factor 10 is required for proper development of the mouse whiskers. 3 Biochemical and biophysical research communications 0006-291X 302 3 562 567 20030300 10.1016/S0006-291X(03)00183-9 12615071 nojisumihare/published_papers/26312962 MATSUMOTO Y NOJI S MIZUNAMI M Time course of protein synthesis-dependent phase of olfactory memory in the cricket Gryllus bimaculatus. Zoological Science 0289-0003 20 4 409 416 20030000 10.2108/zsj.20.409 12719642 nojisumihare/published_papers/26501881 西 真寿美 泰江 章博 大内 淑代 野地 澄晴 森山 啓司 骨格筋形成におけるマイオスタチンの役割の解析 (公社)日本矯正歯科学会 日本矯正歯科学会大会プログラム・抄録集 61 181 181 20021000 nojisumihare/published_papers/25870487 Zhang H Shinmyo Y Hirose A Mito T Inoue Y Ohuchi H Loukeris TG Eggleston P Noji S Extrachromosomal transposition of the transposable element Minos in embryos of the cricket Gryllus bimaculatus. Development, growth & differentiation 0012-1592 44 5 409 417 20021000 10.1046/j.1440-169X.2002.00654.x 12392574 nojisumihare/published_papers/52997512 M Tomita T Nohno T Okuyama S Nishimatsu J Adachi Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction ARCHIVES OF TOXICOLOGY 0340-5761 76 9 530 537 20020900 10.1007/s00204-002-0379-x nojisumihare/published_papers/25870489 Mito T Inoue Y Kimura S Miyawaki K Niwa N Shinmyo Y Ohuchi H Noji S Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model. Mechanisms of development 0925-4773 114 1-2 27 35 20020600 10.1016/S0925-4773(02)00052-7 12175487 nojisumihare/published_papers/29674911 Laura A. Lettice Taizo Horikoshi Simon J. H. Heaney Marijke J. Van Baren Herma C. Van Der Linde Guido J. Breedveld Marijke Joosse Nurten Akarsu Ben A. Oostra Naoto Endo Minoru Shibata Mikio Suzuki Eiichi Takahashi Toshikatsu Shinka Yutaka Nakahori Dai Ayusawa Kazuhiko Nakabayashi Stephen W. Scherer Peter Heutink Robert E. Hill Sumihare Noji Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly Proceedings of the National Academy of Sciences of the United States of America 0027-8424 99 11 7548 7553 20020528 10.1073/pnas.112212199 12032320 2-s2.0-0037188510 nojisumihare/published_papers/25870493 Inoue Y Mito T Miyawaki K Matsushima K Shinmyo Y Heanue TA Mardon G Ohuchi H Noji S Correlation of expression patterns of homothorax, dachshund, and Distal-less with the proximodistal segmentation of the cricket leg bud. Mechanisms of development 0925-4773 113 2 141 148 20020500 10.1016/S0925-4773(02)00017-5 11960702 nojisumihare/published_papers/25870491 Miyawaki K Inoue Y Mito T Fujimoto T Matsushima K Shinmyo Y Ohuchi H Noji S Expression patterns of aristaless in developing appendages of Gryllus bimaculatus (cricket). Mechanisms of development 0925-4773 113 2 181 184 20020500 10.1016/S0925-4773(02)00020-5 11960709 nojisumihare/published_papers/25673875 Nishi M Yasue A Nishimatu S Nohno T Yamaoka T Itakura M Moriyama K Ohuchi H Noji S A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle. Biochem Biophys Res Commun 293 1 247 251 20020400 10.1016/S0006-291X(02)00209-7 12054591 nojisumihare/published_papers/27694053 T Yamaoka K Yoshino T Yamada M Yano T Matsui T Yamaguchi M Moritani J Hata S Noji M Itakura Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 292 1 138 143 20020300 10.1006/bbrc.2002.6601 nojisumihare/published_papers/26889163 野地 澄晴 西 真寿美 泰江 章博 板倉 光夫 山岡 孝 森山 啓司 西松 伸一郎 濃野 勉 細胞成長因子に着目した筋肉再生メカニズムの解明 発生にともなうMyostatin遺伝子発現を解析し,肉牛において発見された点突然変異によるMyostatinの作用を解明する目的で,同じ点突然変異を持つMyostatinを発現するトランスジェニックマウスを作製し,筋肉の変化を解析した.Myostatin遺伝子の発現は,体節に観察され,肢芽の発生に応じて肢芽内に移動し,筋肉形成に関与することが示唆された.肢芽は筋芽細胞では表皮に近い細胞に特異的に発現していた.発生の進行にともない,その傾向は顕著になった.トランスジェニックマウスは体重が約30∼40%増加し,その原因は筋肉量の増加であると予想された.筋肉切片を用いて解析した結果,筋肉量の増加は筋細胞の肥大化よりも筋線維の増加が原因であることが示唆された 厚生労働省精神・神経疾患研究班 厚生労働省精神・神経疾患研究委託費研究報告書 筋ジストロフィー及び関連疾患の臨床病態解明と治療法開発に関する研究 11∼13 109 110 20020300 nojisumihare/published_papers/25109268 Sasak H Yamaoka T Ohuchi H Yasue A Nohno T Kawano H Kato S Itakura M Nagayama M Noji S Identification of cis-elements regulating expression of Fgf10 during limb development. The International journal of developmental biology 0214-6282 46 7 963 967 20020000 12455635 nojisumihare/published_papers/25971615 泰江章博 西松伸一郎 濃野勉 森山啓司 野地澄晴 骨格形成におけるマイオスタチンの役割 生体の科学 52 4 256 261 20010800 10.11477/mf.2425902514 nojisumihare/published_papers/29679212 Toru Takahashi Yoshitaro Itano Sumihare Noji Keiko Matsumoto Naoyuki Taga Syun-ichi Mizukawa Narushi Toda Masaki Matsumi Kiyoshi Morita Masahisa Hirakawa Induction of renal metallothionein in rats with ischemic renal failure Research Communications in Molecular Pathology and Pharmacology 1078-0297 110 3-4 147 160 20010000 12760485 2-s2.0-0037623365 nojisumihare/published_papers/52921364 T Fujii J Funahashi R Matsuura T Izaki H Nakamura T Mikawa H Tanaka Axonal growth of the spinal cord interneurons expressing a homophilic adhesion molecule SC1 ectopically NEUROSCIENCE RESEARCH 0168-0102 38 2 175 181 20001000 10.1016/S0168-0102(00)00158-9 nojisumihare/published_papers/25971611 和田直之 野地澄晴 濃野勉 動物肢の発生と形態形成メカニズム. バイオメカニズム学会誌 23 4 192 198 19991100 10.3951/sobim.23.192 nojisumihare/published_papers/29626291 Gail Lizarraga Deborah Ferrari Michael Kalinowski Hideyo Ohuchi Sumihare Noji Robert A. Kosher Caroline N. Dealy FGFR2 signaling in normal and limbless chick limb buds Wiley-Liss Inc. Developmental Genetics 0192-253X 25 4 331 338 19990000 10.1002/(SICI)1520-6408(1999)25:4<331::AID-DVG7>3.0.CO;2-U 10570465 2-s2.0-0032715881 nojisumihare/published_papers/25971617 和田直之 野地澄晴 濃野勉 四肢形態形成におけるホメオボックス遺伝子. 生体の科学 49 6 588 593 19981200 10.11477/mf.2425901664 nojisumihare/published_papers/25971614 和田直之 野地澄晴 濃野勉 四肢の形態形成の分子メカニズム. 整形外科 49 9 1102 null 19980800 nojisumihare/published_papers/27651766 J Wada K Shikata H Makino S Morioka K Hirata K Ota T Tamatani M Miyasaka T Horiuchi S Noji K Nishikawa F Myokai S Taniguchi YS Kanwar Z Ota The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats NEPHRON 0028-2766 73 2 264 272 19960600 nojisumihare/published_papers/29706901 Jim Wada Kenichi Shikata Hirofumi Makino Shigeru Morioka Kyoji Hirata Kosuke Ota Takuya Tamatani Masayuki Miyasaka Tadashi Horiuchi Sumihare Noji Kiyoshi Nishikawa Fumio Myokai Shigehiko Taniguchi Yashpal S. Kanwar Zensuke Ota The critical role of intercellular adhesion molecule-1 in masugi nephritis in rats Nephron 2235-3186 73 2 264 272 19960000 10.1159/000189050 8773354 2-s2.0-9344237641 nojisumihare/published_papers/29595225 Eiki Koyama Judith L. Leatherman Sumihare Noji Maurizio Pacifici Polarizing activity in early limb cartilaginous condensations Blackwell Publishing Inc. Annals of the New York Academy of Sciences 0077-8923 785 281 283 19960000 10.1111/j.1749-6632.1996.tb56284.x 8702155 2-s2.0-0029743238 nojisumihare/published_papers/27791763 S TAKASHIBA S NOJI F NISHIMURA H OHYAMA H KURIHARA Y NOMURA S TANIGUCHI Y MURAYAMA UNIQUE INTRONIC VARIATIONS OF HLA-DQ-BETA GENE IN EARLY-ONSET PERIODONTITIS JOURNAL OF PERIODONTOLOGY 0022-3492 65 5 379 386 19940500 7913961 nojisumihare/published_papers/29582306 Hironori Matsuura Fumio Myokai Jirô Arata Sumihare Noji Shigehiko Taniguchi Expression of type II transforming growth factor-β receptor mRNA in human skin, as revealed by in situ hybridization Journal of Dermatological Science 0923-1811 8 1 25 32 19940000 10.1016/0923-1811(94)90317-4 7947489 2-s2.0-0028060053 nojisumihare/published_papers/27793251 野地澄晴 濃野勉 発生過程におけるHGFの役割 実験医学 11 9 1125 1129 19930600 nojisumihare/published_papers/29572114 Tsutomu Nohno Sumihare Noji Eiki Koyama Kiyoshi Nishikawa Fumio Myokai Taiichi Saito Shigehiko Taniguchi Differential expression of two MSH-related homeobox genes Chox-7 and Chox-8 during chick limb development Biochemical and Biophysical Research Communications 1090-2104 182 1 121 128 19920115 10.1016/S0006-291X(05)80120-2 1346246 2-s2.0-0026536497 nojisumihare/published_papers/52357472 Takahashi Kojiro 高橋 浩二郎 Hattori Takako 服部 高子 Ohta Hiroyuki 太田 寛行 Noji Sumihare 野地 澄晴 Kato Keijiro 加藤 慶二郎 Taniguchi Shigehiko 谷口 茂彦 FNR-like protein as a regulator for the gene expression of anaerobic respiratory system in oral bacteria. 口腔細菌の嫌気的呼吸系発現に係わるFNR様転写制御蛋白質 The<I>E. coli</I>FNR protein is known as a molecular oxygene sensor and a specific activator for the gene expression of anaerobic respiratory system. In order to survey metabolic response toward molecular oxygen in oral bacteria from viewpoint of FNR-like protein participation, the expression of FNR-like protein in five representative strains of oral bacteria (<I>Actinobacillus actinomycetemcomitans</I>and <I>Streptococcus sanguis</I> as facultative anaerobe, <I>Wolinella recta</I> as microaerophile, and <I>Prevotella intermedia</I> and <I>Fusobacterium nucleatum</I>as strict anaerobe) was investigated with the Western blot method using an anti-FNR rabbit serum prepared against the purified<I>E. coli</I>FNR. For only <I>A. actinomycetemcomitans</I>as a facultative anaerobe, the Western blot test was positive, whereas negative for other four strains. This implies the possibility that in <I>A. actinomycetemcomitans</I>, a regulatory mechanism similar to that in <I>E. coli</I> functions for the expression of anaerobic respiratory genes.<BR>The expression level of FNR-like protein in <I>A. actinomycetemcomitans</I> was found to be enhanced with decreasing rate of the fructose-limited growth at the redox potential fixed around-400 mV, andbe maximum at the redox potential around-250 mV with the growth rate fixed at 0.11 h-1 under the anaerobic conditions. 口腔細菌の酸素分圧の応答性を調べる目的で, E.coliの酸素センサーであると同時に嫌気的呼吸系遺伝子群の活性化因子として機能するFNR蛋白質と類似の蛋白質の口腔細菌での存在を調べた．<I>E. coli</I>の精製FNR蛋白質に対する家兎抗FNR血清を用いたウエスタンブロット法で, 嫌気的条件下で増殖できる代表的な5株の口腔細菌のFNR様因子の同定を行った．通性嫌気性細菌である<I>A. actinomycetemcomitdns</I>についてはFNR様因子を確認することができたが, 嫌気的呼吸系を有する微好気性細菌や偏性嫌気性細菌あるいは糖発酵やアミノ酸異化代謝をエネルギー獲得系として利用する細菌ではそのような蛋白質は確認できなかった．また, <I>A. actinomycetemcomitans</I>でのFNR様因子の発現量は, その増殖速度の減少に対応して増加し, 培地の酸化還元電位が-250mV付近の微好気的条件下で最大であった． Japanese Association for Oral Biology 歯科基礎医学会 Japanese Journal of Oral Biology 歯科基礎医学会雑誌 0385-0137 34 5 459 466 19920000 10.2330/joralbiosci1965.34.459 1390001204683566336 nojisumihare/published_papers/29571632 Masahiro Hamanoue Kouichi Kawaida Sonshin Takao Hisaaki Shimazu Sumihare Noji Kunio Matsumoto Toshikazu Nakamura Rapid and marked induction of hepatocyte growth factor during liver regeneration after ischemic or crush injury Hepatology 1527-3350 16 6 1485 1492 19920000 10.1002/hep.1840160626 1280246 2-s2.0-0026480551 nojisumihare/published_papers/29569588 Yoshitaro Itano Sumihare Noji Eiki Koyama Shigehiko Taniguchi Naoyuki Taga Toru Takahashi Katsuhiko Ono Futami Kosaka Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization Neuroscience Letters 0304-3940 124 1 13 16 19910311 10.1016/0304-3940(91)90811-7 1713315 2-s2.0-0026078083 nojisumihare/published_papers/38173421 野地澄晴 谷口茂彦 濃野勉 ニワトリ肢形態形成とレチノイン酸 生物物理 0582-4052 30 5 239 244 19901000 10.2142/biophys.30.239 nojisumihare/published_papers/29560218 Tsutomu Nohno Sumihare Noji Shigehiko Taniguchi Tauchi Saito The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes Nucleic Acids Research 0305-1048 17 8 2947 2957 19890425 10.1093/nar/17.8.2947 2657652 2-s2.0-0024516182 nojisumihare/published_papers/29560397 Noriyuki Shiraishi Hidehiro Hayashi Yoshio Hiraki Kaname Aono Yoshitaro Itano Futami Kosaka Sumihare Noji Shigehiko Taniguchi Elevation in metallothionein messenger RNA in rat tissues after exposure to X-irradiation Toxicology and Applied Pharmacology 1096-0333 98 3 501 506 19890000 10.1016/0041-008X(89)90178-6 2655174 2-s2.0-0024547117 nojisumihare/published_papers/52997515 T NOHNO Y KASAI T SAITO CLONING AND SEQUENCING OF THE ESCHERICHIA-COLI CHLEN OPERON INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS JOURNAL OF BACTERIOLOGY 0021-9193 170 9 4097 4102 19880900 nojisumihare/published_papers/29556074 Sumihare NOJI Yutaka SATO Ryuta SUZUKI Shigehiko TANIGUCHI Effect of intracellular pH and potassium ions on a primary transport system for glutamate/aspartate in Streptococcus mutans European Journal of Biochemistry 1432-1033 175 3 491 495 19880000 10.1111/j.1432-1033.1988.tb14221.x 2900764 2-s2.0-0023790293 nojisumihare/misc/52454954 井上武刀 井上慎太郎 野木悠平 田良島典子 野地澄晴 三戸太郎 南川典昭 Development of an in vivo screening system for chemically modified siRNA using Gryllus bimaculatus. フタホシコオロギを活用した化学修飾siRNAのin vivoスクリーニング系の構築 日本薬学会年会要旨集(Web) 0918-9823 145th null null 20250000 nojisumihare/misc/52454963 井上智晶 石丸善康 川本晃平 井上慎太郎 渡邉崇人 野地澄晴 三戸太郎 フタホシコオロギをモデルとした不完全変態昆虫におけるE93遺伝子の発現と成虫化に関わる機能の解析 日本分子生物学会年会プログラム・要旨集(Web) 47th null null 20240000 nojisumihare/misc/52454959 島村彩音 井上慎太郎 石丸善康 宮脇克行 高橋章 二川健 野地澄晴 渡邉崇人 三戸太郎 フタホシコオロギの体色パターン形成における白色スクレロチン合成酵素遺伝子の発現と機能の解析 日本分子生物学会年会プログラム・要旨集(Web) 47th null null 20240000 nojisumihare/misc/25692823 Bando T Mito T Hamada Y Ishimaru Y Noji S Ohuchi H Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus. The International journal of developmental biology 0214-6282 62 6-7-8 559 569 20180000 10.1387/ijdb.180048ho 29938767 nojisumihare/misc/27998036 Akihiro Yasue Hitomi Kono Munenori Habuta Tetsuya Bando Keita Sato Junji Inoue Seiichi Oyadomari Sumihare Noji Eiji Tanaka Hideyo Ohuchi Analysis of CRISPR genome-edited founder mice shows relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities MECHANISMS OF DEVELOPMENT 1872-6356 145 S151 S151 20170700 10.1016/j.mod.2017.04.427 nojisumihare/misc/29732248 Hadley Wilson Horch Taro Mito Aleksandar Popadić Hideyo Ohuchi Sumihare Noji Preface Springer Japan The Cricket as a Model Organism: Development, Regeneration, and Behavior v vi 20170101 10.1007/978-4-431-56478-2 2-s2.0-85042828462 nojisumihare/misc/29732234 Hadley Wilson Horch Taro Mito Aleksandar Popadić Hideyo Ohuchi Sumihare Noji The cricket as a model organism: Development, regeneration, and behavior Springer Japan The Cricket as a Model Organism: Development, Regeneration, and Behavior 1 376 20170101 10.1007/978-4-431-56478-2 2-s2.0-85042821642 nojisumihare/misc/26857438 刑部祐里子 菅野茂夫 篠崎一雄 野地澄晴 刑部敬史 CRISPR/Cas9による植物ゲノム編集技術開発と環境応答能の改変 日本植物生理学会年会要旨集 56th 234 null 20150309 nojisumihare/misc/26541865 上田梨紗 石原諒典 渡辺崇人 菅野茂夫 宮脇克行 野地澄晴 刑部祐里子 刑部敬史 CRISPR/Cas9によるトマトIAA9遺伝子を標的としたゲノム編集技術の確立 日本植物生理学会年会要旨集 56th 234 null 20150309 nojisumihare/misc/26541866 上田梨紗 石原諒典 阿部千尋 渡辺崇人 菅野茂夫 宮脇克行 野地澄晴 刑部祐里子 刑部敬史 CRISPR/Cas9によるトマトIAA9遺伝子を標的としたゲノム編集技術の確立 日本生化学会大会(Web) 88th 4T21L-08(3P0837) (WEBONLY)null 20150000 nojisumihare/misc/26857439 鈴木博子 千葉洋史 渡辺崇人 菅野茂夫 宮脇克行 村口元 野地澄晴 刑部敬史 ゲノム編集の利用に向けたCoprinopsis cinereaにおける形質転換方法の確立 日本きのこ学会大会講演要旨集 18th 105 null 20140901 nojisumihare/misc/26857441 宮脇克行 平田翔悟 石川寧子 三戸太郎 刑部敬史 野地澄晴 アグロインフィルトレーション法を用いたF3′5′H過剰発現によるイチゴ花托の着色への影響 日本植物細胞分子生物学会大会・シンポジウム講演要旨集 32nd 141 null 20140730 nojisumihare/misc/35561075 野地 澄晴 刑部 啓史 三戸 太郎 JAPANESE AUTHOR CRISPR法が世界を変える! ネイチャー・ジャパン ; 2010- Natureダイジェスト : 日本語で読む世界の最新科学ニュース 11 4 18 21 20140400 nojisumihare/misc/29629917 Takafumi Hiro Tadateru Takayama Hironori Haruta Masayuki Mitsumori Kimio Tanaka Junichi Kawanabe Sumihare Noji Atsushi Hirayama 3D image reconstruction of Histopathological structure of Atherosclerotic plaque using a novel technique with film tomography Elsevier Inc. JACC: Cardiovascular Imaging 1876-7591 7 12 1283 1285 20140000 10.1016/j.jcmg.2014.04.028 25496549 2-s2.0-84927924661 nojisumihare/misc/26857421 西池 氏裕 野地 澄晴 刑部 敬史 徳島の植物工場を考える : ゲノム編集技術を軸に徳島をアグリノベーションのメッカに 徳島経済研究所 徳島経済 93 78 84 20140000 nojisumihare/misc/35424014 渡辺 崇人 三戸 太郎 野地 澄晴 Gene Knockout in the Cricket Using ZFN/TALEN ZFN/TALENを用いたコオロギの遺伝子ノックアウト (特集 ゲノム編集革命 : 遺伝子改変はZFN・TALEN・CRISPR/Cas三強時代へ) 学研メディカル秀潤社 ; 1982- 細胞工学 0287-3796 32 5 543 549 20130000 nojisumihare/misc/27036380 Momoko Kitaoka Masayuki Mitsumori Kounosuke Hayashi Yoshiyuki Hiraishi Hisao Yoshinaga Koji Nakano Katsuyuki Miyawaki Sumihare Noji Masahiro Goto Masahiro Goto Noriho Kamiya Noriho Kamiya Transglutaminase-mediated in situ hybridization (TransISH) system: A new methodology for simplified mRNA detection Analytical Chemistry 0003-2700 84 5885 5891 20120717 10.1021/ac2034198 22746100 2-s2.0-84863968503 nojisumihare/misc/52333267 宮脇克行 角村寧子 浜岡宏和 三戸太郎 大内淑代 野地澄晴 イチゴ花托におけるアントシアニン合成関連遺伝子の機能解析 日本農芸化学会大会講演要旨集(Web) 2186-7976 2012 null null 20120000 nojisumihare/misc/52323624 渡辺崇人 落合博 佐久間哲史 中井綾 中村太郎 板東哲哉 三戸太郎 山本卓 野地澄晴 ZFN及びTALENを使用したコオロギ変異体の作製 日本分子生物学会年会プログラム・要旨集(Web) 35th null null 20120000 nojisumihare/misc/52333271 宮脇克行 福岡幸 角村寧子 浜岡宏和 三戸太郎 大内淑代 野地澄晴 RNAi法を用いたイチゴ花托の着色過程におけるF3'H遺伝子の機能解析 日本植物細胞分子生物学会大会・シンポジウム講演要旨集 29th null null 20110000 nojisumihare/misc/28315263 Hideyo Ohuchi Junji Inoue Sayuri Tomonari Sumihare Noji Non-canonical opsin proteins are localized to various retinal neurons in the chicken NEUROSCIENCE RESEARCH 0168-0102 71 E255 E255 20110000 10.1016/j.neures.2011.07.1111 nojisumihare/misc/28300753 Taro Mito Taro Nakamura Tetsuya Bando Hideyo Ohuchi Sumihare Noji The advent of RNA interference in Entomology ENTOMOLOGICAL SCIENCE 1343-8786 14 1 1 8 20110100 10.1111/j.1479-8298.2010.00408.x nojisumihare/misc/52333282 入江健太郎 阪上友梨 福岡幸 宮脇克行 角村寧子 広田恵介 三戸太郎 大内淑代 野地澄晴 アグロインフィルトレーション法を用いたRNAiによるイチゴ青色光受容体の機能解析 生化学 0037-1017 null null 20100000 nojisumihare/misc/29054657 Hideyo Ohuchi Hitomi Fukui Akane Matsuyo Sayuri Tomonari Sumihare Noji Dual splice variants of autotaxin control chicken diencephalon-mesencephalon development downstream of Pax6 MECHANISMS OF DEVELOPMENT 0925-4773 126 S74 S74 20090800 10.1016/j.mod.2009.06.077 nojisumihare/misc/29053327 Katsuyuki Miyawaki Taro Mito Taro Nakamura Tetsuya Bando Kimio Tanaka Hideyo Ohuchi Sumihare Noji Involvement of the Hedgehog/Engrailed signaling in regeneration of the posterior structures in the amputated leg of the cricket Gryllus bimaculatus MECHANISMS OF DEVELOPMENT 0925-4773 126 S294 S294 20090800 10.1016/j.mod.2009.06.799 nojisumihare/misc/29050567 Tetsuya Bando Taro Mito Yuko Maeda Taro Nakamura Fumiaki Ito Takahito Watanabe Hideyo Ohuchi Sumihare Noji Regulation of leg size and shape by the Dachsous/Fat signalling pathway during regeneration in Gryllus bimaculatus MECHANISMS OF DEVELOPMENT 0925-4773 126 S293 S294 20090800 10.1016/j.mod.2009.06.797 nojisumihare/misc/29046346 Taro Nakamura Taro Mito Masato Yoshizaki Tetsuya Bando Kimio Tanaka Hideyo Ohuchi Sumihare Noji Dynamics of cellular aggregation and differentiation during early development of transgenic crickets MECHANISMS OF DEVELOPMENT 0925-4773 126 S254 S254 20090800 10.1016/j.mod.2009.06.666 nojisumihare/misc/304382 大内淑代 野地澄晴 ホールマウントin situハイブリダイゼーション法(B.in situハイブリダイゼーション法) 日本組織細胞化学会 組織細胞化学 34 69 81 20090710 nojisumihare/misc/28803387 Tetsuya Bando Yuko Maeda Taro Nakamura Taro Mito Hideyo Ohuchi Sumihare Noji Fat and dachsous protocadherin are required for proper proximodistal and circumferential regeneration of amputated legs in the cricket, Gryllus bimaculatus GENES & GENETIC SYSTEMS 1880-5779 82 6 532 532 20071200 nojisumihare/misc/28795668 Yuko Maeda Tetsuya Bando Taro Nakamura Taro Mito Hideyo Ohuchi Sumihare Noji Warts, Expanded and Dachs are required for proper regeneration of amputated legs in the cricket, Gryllus bimaculatus GENES & GENETIC SYSTEMS 1880-5779 82 6 532 532 20071200 nojisumihare/misc/48628092 木内 奈央 谷本 起穂 大澤 裕 砂田 芳秀 野地 澄晴 森山 啓司 マイオスタチンに対するRNA干渉法による骨格筋形成の調節 (公社)日本矯正歯科学会 日本矯正歯科学会大会プログラム・抄録集 66 153 153 20070900 nojisumihare/misc/39174608 NAKAMURA Taro 中村 太郎 HAMADA Asuka 濱田 明日香 BANDO Tetsuya 板東 哲哉 MITO Taro 三戸 太郎 OHUCHI Hideyo 大内 淑代 NOJI Sumihare 野地 澄晴 Gene functional analyses of the cricket, Gryllus bimaculatus, using RNAi RNA干渉を用いたコオロギの遺伝子機能解析法の研究 A cricket Gryllus bimaculatus is a typical hemimetabolous intermediate germ insect, in which the processes of segmentation and appendage formation differ considerably from those in Drosophila, a holometabolous long germ insect. Furthermore, the nymph of cricket possesses the ability to regenerate these legs. To gain insight into molecular mechanisms of development and leg regeneration, we established the embryonic, parental and nymphal RNAi techniques to analyze their functions. Our RNAi analyses revealed that (1) Caudal probably acts as a crucial morphogen with a posterior-to-anterior gradient to form of posterior region; (2) the Wingless signaling pathway is involved in the process of leg regeneration and determination of positional information in the leg segment; (3) Fragile X, Gryllus ortholog of responsible gene for human fragile x syndrome, is involved in the cricket calling song; (4) Laccase 2 coding for diphenol oxidase is involved in cuticle tanning (or sclerotization and pigmentation) in the cricket. コオロギは，胚発生や脚形成の様式がショウジョウバエと異なる．また，コオロギ幼虫の脚は切断されても再生可能であることが知られている．コオロギの胚発生と脚再生過程に働く遺伝子の機能を解析するために，我々はRNAi法を用いている．これまでに， embryonic, parentalそして，nymphal RNAi法を確立し，次の事を明らかにした．コオロギにおいては，(1)ショウジョウバエ(Bicoid)と異なる因子(Caudal)により，胚の前後の位置情報が与えられている可能性がある，(2)winglessシグナル伝達経路が再生過程で働いておりそして，再生過程における遠近軸に沿った位置情報の決定に関与している，(3)ヒト脆弱X症侯群の原因遺伝子のコオロギホモログfmrは，コオロギの鳴き方に影響を与える遺伝子である，(4)diphenol oxidaseをコードするlaccase 2はコオロギ外骨格の着色，硬化に関与している． The Institute of Electronics, Information and Communication Engineers 一般社団法人電子情報通信学会 IEICE technical report 電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス 0913-5685 107 154 91 93 20070713 nojisumihare/misc/18808016 大内淑代 野地澄晴 ホールマウントin situハイブリダイゼーション法(C.in situハイブリダイゼーション法) 日本組織細胞化学会 組織細胞化学 2007 91 103 20070710 nojisumihare/misc/25313933 福井 ひと美 岡本 麻友美 山中 瑞恵 佐伯 智佳子 尾ノ井 基嘉 松田 洋尚 湯藤 嘉文 田中 将之 青木 淳賢 新井 洋由 野地 澄晴 大内 淑代 ニワトリ神経発生時のautotaxinの機能的研究(Functional studies of Autotaxin during chicken neural development) 日本発生生物学会・日本細胞生物学会 日本発生生物学会・日本細胞生物学会合同大会要旨集 40·59 104 104 20070500 nojisumihare/misc/25287365 松田 洋尚 尾ノ井 基嘉 林原 康典 三ツ森 正之 田中 将之 青木 淳賢 新井 洋由 野地 澄晴 大内 淑代 マウス・ニワトリの発生時におけるリン酸化脂質生成酵素遺伝子autotaxinの多様な発現パターン(Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development) 日本発生生物学会・日本細胞生物学会 日本発生生物学会・日本細胞生物学会合同大会要旨集 40·59 151 151 20070500 nojisumihare/misc/52315031 岡田只士 大澤裕 林紗織 久我敦 村上龍文 西松伸一郎 濃野勉 野地澄晴 砂田芳秀 マウス脱神経筋萎縮モデルに対するマイオスタチン阻害効果の検討 生化学 0037-1017 null null 20070000 nojisumihare/misc/28777012 Tashifurni Takahashi Hisayo Kunitou Asuka Hamada Yukihisa Matsumoto Taro Mito Sumihare Noji Makoto Mizunami Nitric oxide synthase dsRNA interfere with long-term memory formation in an insect NEUROSCIENCE RESEARCH 0168-0102 58 S112 S112 20070000 nojisumihare/misc/48628093 大澤 裕 萩原 宏毅 村上 龍文 土田 邦博 宮園 浩平 野地 澄晴 砂田 芳秀 Caveolin-3欠損症で認められるMyostatin signal活性化による筋萎縮機構 (一社)日本神経学会 臨床神経学 1882-0654 46 12 1121 1121 20061200 nojisumihare/misc/28886908 Toshifumi Takahashi Hisayo Kunitou Yukihisa Matsumoto Taro Mito Sumihare Noji Makoto Mizunami Effect of nitric oxide synthase (NOS) dsRNA in LTM formation ZOOLOGICAL SCIENCE 0289-0003 23 12 1202 1202 20061200 nojisumihare/misc/28871827 Aska Hamada Eri Honda-Sumi Taro Mito Hideyo Ohuchi Sumihare Noji Involvement of fragile X mental retardation (fmr) in stridulation of the two-spotted cricket (gryllus bimaculatus) ZOOLOGICAL SCIENCE 0289-0003 23 12 1222 1222 20061200 nojisumihare/misc/47626176 田尾 嘉誉 楠本 涼 小野 勝彦 清水 美幸 野地 澄晴 大内 淑代 マウス眼瞼形成におけるFGF10の機能 増殖と細胞移動の2つの役割を担う 日本発生生物学会 日本発生生物学会大会講演要旨集 38 161 161 20050500 nojisumihare/misc/29686105 Taizo Horikoshi Naoto Endo Minoru Shibata Peter Heutink Robert E. Hill Sumihare Noji Disruption of the C7orf2/Lmbr1 genic region is associated with preaxial polydactyly in humans and mice Journal of Bone and Mineral Metabolism 0914-8779 21 1 1 4 20030000 10.1007/s007740300000 12491086 2-s2.0-0043258813 nojisumihare/misc/53017621 T Yuasa H Kataoka N Kinto M Iwamoto M Enomoto-Iwamoto SI Iemura N Ueno Y Shibata H Kurosawa A Yamaguchi Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2 JOURNAL OF CELLULAR PHYSIOLOGY 0021-9541 193 2 225 232 20021100 10.1002/jcp.10166 nojisumihare/misc/25971598 Tao Hirotaka Yoshimoto Yasuko Yoshioka Hidefumi Nohno Tsutomu Noji Sumihare Ohuchi Hideyo FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin. Mechanisms of development 116 1-2 39 49 20020800 10.1016/S0925-4773(02)00131-4 nojisumihare/misc/43485436 田尾嘉誉 吉岡秀文 濃野勉 三戸太郎 野地澄晴 大内淑代 ニワトリ皮膚構造物形成におけるFGF10シグナルの役割 日本発生生物学会大会発表要旨集 35th null null 20020000 nojisumihare/misc/53017648 T Sugiyama A Yamaguchi A possible role of osteocalcin carboxylation in compensation mechanism in bone. JOURNAL OF BONE AND MINERAL RESEARCH 0884-0431 16 S525 S525 20010900 nojisumihare/misc/50074695 岩花 弘之 早川 盛禎 柳沢 健 多胡 憲治 黒岩 憲二 芳賀 靖 増沢 紀男 野地 澄晴 冨永 眞一 ST2LV:ST2遺伝子産物の新しいバリアントについて (公社)日本生化学会 生化学 0037-1017 72 8 1031 1031 20000800 nojisumihare/misc/35072044 野地 澄晴 田中 弘之 山口 朗 鼎談 形態形成遺伝子とその異常 (特集 形態形成遺伝子とその異常--基礎と臨床) 現代医療社 現代医療 0533-7259 32 8 1864 1878 20000800 nojisumihare/misc/25971596 Kawakami Yasuhiko Wada Naoyuki Nishimatsu Shin-ichiro Komaguchi Chikako Noji Sumihare Nohno Tsutomu Identification of chick frizzled-10 expressed in the developing limb and the central nervous system. Mechanisms of development 91 1-2 375 378 20000300 10.1016/S0925-4773(99)00301-9 nojisumihare/misc/53003863 岩花 弘之 柳沢 健 多胡 憲治 黒岩 憲二 芳賀 靖 増沢 紀男 野地 澄晴 富永 眞一 ニワトリST2遺伝子の胎生期における発現 (公社)日本生化学会 生化学 0037-1017 71 8 942 942 19990800 nojisumihare/misc/29628127 Hideyo Ohuchi Sumihare Noji Fibroblast-growth-factor-induced additional limbs in the study of initiation of limb formation, limb identity, myogenesis, and innervation Cell and Tissue Research 0302-766X 296 1 45 56 19990000 10.1007/s004410051265 10199964 2-s2.0-0032901880 nojisumihare/misc/38987745 ISHIMARU Yoshiyasu 石丸 善康 SUGIHARA Minoru 椙原 穂 YOSHIOKA Hidefumi 吉岡 秀文 ITOH Hiroyuki 伊藤 裕之 OHUCHI Hideyo 田尾 嘉誉 MENO Chikara 大内 淑代 HAMADA Hiroshi 目野 主税 NOJI Sumiharu 濱田 博司 野地 澄晴 A mechanism involved in determination of left-right axis in chick embryos ニワトリ胚の左右軸決定のメカニズム 日本分子生物学会年会プログラム・講演要旨集 21 603 603 19981201 nojisumihare/misc/38987733 KAWAKAMI Y. 川上 泰彦 WADA N. 和田 直之 NISHIMATU S. 西松 伸一郎 NOJI S. 野地 澄晴 NOHNO N. 濃野 勉 Analysis of frizzled-10 during chick limb development ニワトリ四肢発生過程におけるfrizzled-10の働きの解析 日本分子生物学会年会プログラム・講演要旨集 21 603 603 19981201 nojisumihare/misc/38998679 NOJI S. 野地 澄晴 Signal Factors in Limb Morphogenesis 四肢形成のシグナル因子 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association 0021-5325 72 8 S1476 null 19980825 nojisumihare/misc/26095848 T. 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Shh(Sonic hedgehog), Dhh(Desert hedgehog). ノックアウトマウス・データブック Shh(Sonic hedgehog),Dhh(Desert hedgehog) Mol Med 0918-6557 34 Dec 458 459 19970000 nojisumihare/misc/25656557 小柴和子 野地澄晴 Knockout Mouse Data Book. FGFR-1, FGFR-3. ノックアウトマウス・データブック FGFR‐1,FGFR‐3 Mol Med 0918-6557 34 Dec 173 174 19970000 nojisumihare/misc/25656556 小柴和子 野地澄晴 Knockout Mouse Data Book. BMPR-IA(bone morphogenetic protein receptor-IA). ノックアウトマウス・データブック BMPR‐IA(bone morphogenetic protein receptor‐IA) Mol Med 0918-6557 34 Dec 53 null 19970000 nojisumihare/misc/25656555 小柴和子 野地澄晴 Knockout Mouse Data Book. BMP-1(bone morphogenetic protein 1). ノックアウトマウス・データブック BMP‐1(bone morphogenetic protein 1) Mol Med 0918-6557 34 Dec 50 51 19970000 nojisumihare/misc/25971585 Kawakami Yasuhiko Ishikawa Tetsuya Shimabara Masakiyo Tanda Nobuya Enomoto-lwamoto Motomi Iwamoto Masahiro Kuwana Takashi Ueki Ayako Noji Sumihare Nohno Tsutomu BMP signaling during bone pattern determination in the developing limb. Development (Cambridge, England) 122 11 3557 3566 19961100 nojisumihare/misc/38987218 荒賀 章博 中川 尚 大畠 健 山本 篤世 大内 淑代 吉岡 秀文 濃野 勉 野地 澄晴 ニワトリ重複肢誘導におけるWnt, Bmp, Fgfの作用機構 日本分子生物学会年会プログラム・講演要旨集 19 671 671 19960801 nojisumihare/misc/38987178 石川 哲也 川上 泰彦 島原 将精 丹田 信也 湊川 洋介 桑名 貴 野地 澄晴 濃野 勉 四肢形態形成におけるBMPの役割 日本分子生物学会年会プログラム・講演要旨集 19 833 833 19960801 nojisumihare/misc/38987122 丹田 信也 川上 泰彦 島原 将精 石川 哲也 野地 澄晴 濃野 勉 ニワトリ四肢のパターン形成におけるWnt遺伝子群の機能 日本分子生物学会年会プログラム・講演要旨集 19 833 833 19960801 nojisumihare/misc/25971589 Koyama Eiki Yamaai Tomoichiro Iseki Sachiko Ohuchi Hideyo Nohno Tsutomu Yoshioka Hidefumi Hayashi Yoshio Leatherman Judith L Golden Eleanor B Noji Sumihare Pacifici Maurizio Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse. Developmental dynamics : an official publication of the American Association of Anatomists 206 1 59 72 19960500 10.1002/(SICI)1097-0177(199605)206:1<59::AID-AJA6>3.0.CO;2-# nojisumihare/misc/25971572 Ishikawa Tetsuya Yoshioka Hidefumi Ohuchi Hideyo Noji Sumihare Nohno Tsutomu Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos. 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Biochimica et biophysica acta 1089 2 273 275 19910600 10.1016/0167-4781(91)90024-G nojisumihare/misc/25971581 Nohno Tsutomu Noji Sumihare Koyama Eiki Ohyama Kazuhiko Myokai Fumio Kuroiwa Atsushi Saito Taiichi Taniguchi Shigehiko Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 0092-8674 64 6 1197 1205 19910300 10.1016/0092-8674(91)90274-3 1672266 nojisumihare/misc/27793258 N ISHIDA S NOJI K ONO E KOYAMA T NOHNO S TANIGUCHI A TOKUNAGA T FUJII Y MITSUI DIURNAL REGULATION OF PER REPEAT MESSENGER-RNA IN THE SUPRACHIASMATIC NUCLEUS IN RAT-BRAIN NEUROSCIENCE LETTERS 0304-3940 122 1 113 116 19910100 10.1016/0304-3940(91)90206-9 nojisumihare/misc/25913500 野地澄晴 小山英樹 明貝文夫 谷口茂彦 濃野勉 斉藤泰一 黒岩厚 内山孝司 井出宏之 Induction of Chox-4 homeobox gene expression by retinoic acid and the ZPA in chick limb buds. ニワトリ肢芽におけるレチノイン酸およびZPAによるホメオボックス遺伝子Chox‐4の発現誘導 日本発生生物学会大会発表要旨集 24th 98 null 19910000 nojisumihare/misc/25971621 S NOJI T MATSUO E KOYAMA T YAMAAI T NOHNO N MATSUO S TANIGUCHI EXPRESSION PATTERN OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTOR GENES IN ADULT-RAT EYES BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 168 1 343 349 19900400 10.1016/0006-291X(90)91714-4 2328010 nojisumihare/misc/27627675 J SASAKI S WATANABE T NOMURA S KANDA T YAMAAI E KOYAMA S NOJI S TANIGUCHI SYNTHESIS OF ACTIN IN THE NONCILIATED BRONCHIOLAR EPITHELIAL (CLARA) CELLS OF PERINATAL RATS DEMONSTRATED BY ELECTRON-MICROSCOPY AND INSITU HYBRIDIZATION ACTA HISTOCHEMICA ET CYTOCHEMICA 1347-5800 23 4 453 465 19900000 10.1267/ahc.23.453 nojisumihare/misc/25971622 S NOJI N TAKAHASHI T NOHNO E KOYAMA T YAMAAI M MURAMATSU S TANIGUCHI EXPRESSION PATTERN OF THE HOMEOBOX GENE HOX-3.5 DURING MOUSE DEVELOPMENT, AS REVEALED BY A SIMPLIFIED INSITU HYBRIDIZATION METHOD ACTA HISTOCHEMICA ET CYTOCHEMICA 1347-5800 23 3 353 366 19900000 10.1267/ahc.23.353 nojisumihare/misc/25971592 Noji Sumihare Yamaai Tomoichiro Koyama Eiki Nohno Tsutomu Fujimoto Wataru Arata Jiro Taniguchi Shigehiko Expression of retinoic acid receptor genes in keratinizing front of skin. FEBS letters 0014-5793 259 1 86 null 19891200 10.1016/0014-5793(89)81501-7 2480921 nojisumihare/misc/25971593 Noji Sumihare Yamaai Tomoichiro Koyama Eiki Nohno Tsutomu Taniguchi Shigehiko Spatial and temporal expression pattern of retinoic acid receptor genes during mouse bone development. FEBS letters 0014-5793 257 1 93 96 19891000 10.1016/0014-5793(89)81794-6 2553496 nojisumihare/misc/38453143 NOJI S. 野地 澄晴 Localization of epidermal growth factor and nerve growth factor mRNAs in mouse submandibular gland by a simplified in situ hybridization with riboprobes リボプロ-ブを用いた改良in situハイブリダイゼ-ション法による上皮成長因子および神経成長因子遺伝子のマウス顎下腺における発現部位 日本アイソト-プ協会 Radioisotopes 0033-8303 38 9 p366 372 19890900 nojisumihare/misc/25971623 S NOJI T NOHNO T SAITO S TANIGUCHI THE NARK GENE-PRODUCT PARTICIPATES IN NITRATE TRANSPORT INDUCED IN ESCHERICHIA-COLI NITRATE-RESPIRING CELLS FEBS LETTERS 1873-3468 252 1-2 139 143 19890700 10.1016/0014-5793(89)80906-8 2668029 nojisumihare/misc/52997509 T NOHNO Y KASAI T SAITO NOVEL CDNA SEQUENCE POSSIBLY GENERATED BY ALTERNATIVE SPLICING OF A MOUSE GLUCOCORTICOID RECEPTOR GENE TRANSCRIPT FROM SHIONOGI CARCINOMA-115 NUCLEIC ACIDS RESEARCH 0305-1048 17 1 445 445 19890100 10.1093/nar/17.1.445 2911477 nojisumihare/misc/52997510 T NOHNO T SAITO 2 TRANSCRIPTIONAL START SITES FOUND IN THE PROMOTER REGION OF ESCHERICHIA-COLI GLUTAMINE PERMEASE OPERON, GLNHPQ NUCLEIC ACIDS RESEARCH 0305-1048 15 6 2777 2777 19870300 nojisumihare/misc/52997518 T NOHNO T SAITO EXPRESSION OF THE ESCHERICHIA-COLI GLNHPQ OPERON IS REGULATED AT TANDEM PROMOTERS JAPANESE JOURNAL OF PHARMACOLOGY 0021-5198 43 P198 P198 19870000 nojisumihare/misc/52997511 T NOHNO S WATANABE T SAITO EVALUATION OF EFFECT OF HOST IMMUNITY ON GROWTH OF ANDROGEN-DEPENDENT SHIONOGI CARCINOMA-115 IN THE MOUSE CANCER LETTERS 0304-3835 33 2 125 130 19861100 nojisumihare/misc/52997508 T NOHNO T SAITO S WATANABE SEDATIVE ACTION OF CHLORINATED DERIVATIVES OF CINNAMIC ACID IN THE MOUSE JOURNAL OF PHARMACY AND PHARMACOLOGY 0022-3573 33 7 483 484 19810000 nojisumihare/misc/28045392 M SUGIHARA Y FURUTA K NISHIKAWA PHYLOGENY OF THE GENUS LYCORIS WITH SPECIAL REFERENCE TO KARYOTYPE, NUCLEAR-DNA CONTENT AND MORPHOLOGY JAPANESE JOURNAL OF GENETICS 0021-504X 56 6 637 637 19810000 nojisumihare/misc/25971583 Noji Sumihare Koyama Eiki Myokai Fumio Nohno Tsutomu Ohuchi Hideyo Nishikawa Kiyoshi Taniguchi Shigehiko Differential expression of three FGF receptor genes, FGFR1, FGFR2 and FGFR3, in chick bone formation. 199200 Dentistry in Japan 29 36 40 nojisumihare/books_etc/48002777 野地, 澄晴 最先端コオロギ学 : 世界初!新しい生物学がここにある 北隆館 20220400 nojisumihare/books_etc/48002790 野地, 澄晴 最強の食材コオロギフードが地球を救う 小学館 20210800 nojisumihare/books_etc/10539972 ルイス ウォルパート 野地 澄晴 大内 淑代 発生生物学 (サイエンス・パレット) 丸善出版 20130726 nojisumihare/books_etc/10539973 野地澄晴 理系のアナタが知っておきたいラボ生活の中身∼バイオ系の歩き方 羊土社 20120420 nojisumihare/books_etc/10539974 打波 守 野地澄晴 アット・ザ・ベンチ バイオ実験室の統計学 -エクセルで学ぶ生物統計の基本- メディカルサイエンスインターナショナル 20110328 nojisumihare/books_etc/10539975 Roland Ennos 打波 守 野地 澄晴 パソコンで簡単!すぐできる生物統計―統計学の考え方から統計ソフトSPSSの使い方まで 羊土社 20070801 nojisumihare/books_etc/10539976 野地 澄晴 免疫染色 & in situハイブリダイゼーション最新プロトコール―抗体・プローブの作製から手法の選択,顕微鏡観察まで実践テクニックが余さずわかる! (注目のバイオ実験シリーズ) 羊土社 20060901 nojisumihare/books_etc/10539977 上野 直人 八杉 貞雄 野地 澄晴 発生システムのダイナミクス 共立出版 20060110 nojisumihare/books_etc/10539978 上野 直人 野地 澄晴 キーワードで理解する発生・再生イラストマップ 羊土社 20051201 nojisumihare/books_etc/10539979 佐藤 矩行 倉谷 滋 長谷部 光泰 野地 澄晴 発生と進化 (シリーズ進化学 (4)) 岩波書店 20040608 nojisumihare/books_etc/10539980 上野 直人 野地 澄晴 発生生物学がわかる (わかる実験医学シリーズ) 羊土社 20031200 nojisumihare/books_etc/10539981 関村 利朗 森田 利仁 野地 澄晴 生物の形の多様性と進化―遺伝子から生態系まで 裳華房 20030700 nojisumihare/books_etc/10539846 ホルモンの分子生物学6 発生と成長因子・ホルモン(共著) 学会出版センター 19960000 nojisumihare/books_etc/10539847 Molecular Mechanism of Morphogenesis 19930000 nojisumihare/books_etc/10539845 in situハイブリダイゼーションによるRNAの検出 新生化学実験講座2 核酸IV 遺伝子の複製と発現 19930000 nojisumihare/books_etc/10539844 形づくりの分子メカニズム(共著) 羊土社 19930000 第3回Duodecimシンポジウム アブストラクト賞 19950000