type: misc

label: url

en: Cricket: The third domesticated insect.

ja: Cricket: The third domesticated insect.

en: Many researchers are using crickets to conduct research on various topics related to development and regeneration in addition to brain function, behavior, and biological clocks, using advanced functional and perturbational technologies such as genome editing. Recently, crickets have also been attracting attention as a food source for the next generation of humans. In addition, crickets are increasingly being used as disease models and biological factories for pharmaceuticals. Cricket research has thus evolved over the last century from use primarily in highly important basic research, to use in a variety of applications and practical uses. These insects are now a state-of-the-art model animal that can be obtained and maintained in large quantities at low cost. We therefore suggest that crickets are useful as a third domesticated insect for scientific research, after honeybees and silkworms, contributing to the achievement of global sustainable development goals.

en: Current Topics in Developmental Biology

ja: Current Topics in Developmental Biology


en: 持続可能な次世代タンパク質源としての食用コオロギ

ja: 持続可能な次世代タンパク質源としての食用コオロギ

en: Seibutsu-kogaku Kaishi

ja: 生物工学会誌


en: Molecular mechanisms of insect metamorphosis: insights from studies of the cricket Gryllus bimaculatus

ja: 昆虫変態の分子機構:コオロギの研究から

en: 昆虫と自然

ja: 昆虫と自然


en: Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus

en: This review summarizes recent advances in leg regeneration research, focusing on the cricket Gryllus bimaculatus. Recent studies have revealed molecular mechanisms on blastema formation, establishment of positional information, and epigenetic regulation during leg regeneration. Especially, these studies have provided molecular bases in classical conceptual models such as the polar coordinate model, the intercalation model, the boundary model, the steepness model, etc., which were proposed to interpret regeneration processes of the cockroach legs. When a leg is amputated, a blastema is formed through the activation of the Janus-kinase (Jak)/Signal-Transduction-and-Activator-of-Transcription (STAT) pathway. Subsequently, the Hedgehog/Wingless/Decapentaplegic/Epidermal-growth-factor pathways instruct distalization in the blastema, designated as the molecular boundary model. Downstream targets of this pathway are transcription factors Distal-less (Dll) and dachshund (dac), functioning as key regulators of proximodistal pattern formation. Dll and dac specify the distal and proximal regions in the blastema, respectively, through the regulation of tarsal patterning genes. The expression of leg patterning genes during regeneration may be epigenetically controlled by histone H3K27 methylation via Enhancer-of-zeste and Ubiquitously-transcribed-tetratricopeptide-repeat-gene-X-chromosome. For the molecular mechanism of intercalation of the missing structures between the amputated position and the most distal one, Dachsous/Fat (Ds/Ft) steepness model has been proposed, in which the Ds/Ft pathway maintains positional information and determines leg size through dac expression. This model was theoretically verified to interpret the experimental results obtained with cricket legs. Availability of whole-genome sequence information, regeneration-dependent RNA interference, and genome editing technique will have the cricket be an ideal model system to reveal gene functions in leg regeneration.

en: The International Journal of Developmental Biology


en: Gene Knockout in the Cricket Using ZFN/TALEN

ja: ZFN/TALENを用いたコオロギの遺伝子ノックアウト

en: 細胞工学

ja: 細胞工学


en: 脚再生の分子メカニズム --- 再生芽誘導とサイズの決定について

ja: 脚再生の分子メカニズム --- 再生芽誘導とサイズの決定について

en: Experimental Medicine

ja: 実験医学


en: コオロギから学ぶ生物の発生システムの進化

ja: コオロギから学ぶ生物の発生システムの進化


en: 昆虫における初期発生システムの進化

ja: 昆虫における初期発生システムの進化

en: タンパク質核酸酵素

ja: タンパク質核酸酵素


en: 昆虫の体はどうやってできたか?

ja: 昆虫の体はどうやってできたか?

en: 遺伝

ja: 遺伝