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en: Naturally occurring AQP5 mutations in rats and humans and their affected phenotypes

en: Veterinarski Glasnik

ja: Veterinarski Glasnik


en: Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions

en: International Journal of Molecular Sciences


en: Reversible Conversion among Subtypes of Salivary Gland Duct Cells as Identified by Production of a Variety of Bioactive Polypeptides

en: Four major kallikreins (mK1, mK22, mK9, and mK13) were identified in the mouse submandibular gland (SMG). mK1, a true tissue kallikrein, was used as a protein marker to identify different types of SMG granular convoluted tubule (GCT) cells along with epidermal growth factor (EGF), nerve growth factor (NGF), and renin. Kallikrein mK1 was localized in a very small number (~5%) of GCT cells, which were scattered throughout the GCT, indicating that the majority of GCT cells are mK1-negative. Among mK1-positive cells, particularly strong signals were observed in a small number of narrow cells, recognized as slender granular cells (SG cells, Type IV), in the GCT. After postnatal development of the SMG, GCT cells are no longer uniform based on the bioactive substances (mK1, EGF, NGF, and renin) that they produce and secrete. GCT cells were classified into four subtypes, Types I-IV, and it became clear that these subtypes are complicatedly and reversibly converted by the endocrine hormones 5α-dihydrotestosterone (DHT) and triiodothyronine (T). Duct segments with similar morphology or hormone dependency were recognized in the sublingual and parotid glands. The presence of duct cells with such characteristics is therefore a common feature of the three major salivary glands of rodents.

en: Acta Histochemica et Cytochemica

ja: Acta Histochemica et Cytochemica


en: Possible Existence of a Salivary Gland-Oral Mucosa/Gingiva Axis Under Challenges by Endotoxins

en: Journal of Molecular and Cellular Biology Forecast


en: Physiological role of aquaporin 5 in salivary glands

en: Regarding the 13 known mammalian aquaporins (AQPs), their functions in their expressing tissues, effects of their mutation/polymorphisms in humans, and effects of knockout of their genes are summarized in this review article. The roles of AQP5, an exocrine gland-type water channel, in the salivary gland under normal and pathophysiological conditions are reviewed in detail. First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested. Next, involvement of the parasympathetic nervous system on the AQP5 levels in the acinar cells of the submandibular and that of a β-adrenergic agonist on those in the parotid gland are described. That is, chorda tympani denervation induces autophagy of the submandibular gland, causing AQP5 degradation/metabolism, whereas isoproterenol, a β-adrenergic agonist, causes first an increase then decrease in AQP5 levels in the parotid gland, which action is coupled with the secretory-restoration cycle of amylase-containing secretory granules. The PG also responded to endotoxin, a lipopolysaccharide that activates NF-κB and MAPK pathways. Elevated NF-κB and AP-1 (c-Fos/c-Jun) form a complex that can bind to the NF-κB-responsive element on the AQP5 promoter and thus potentially downregulate AQP5 transcription. Salivary gland pathologies and conditions involving AQP5 and possible treatments are described as well.

en: Pflügers Archiv : European Journal of Physiology


en: Expression of AQP5 in the salivary gland and its autonomic regulation (in Japanese),

ja: 唾液腺におけるアクアポリン5 の発現と自律神経系による制御

en: Journal of the Japan Salivary Gland Society

ja: 日本唾液腺学会誌


en: Effects of naturally occurring mutation in rat aquaporin 5 (in Japanese)

ja: アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響

en: Shikoku Dental Research

ja: 四国歯学会雑誌


en: Suppression of aquaporin 5 gene expression by endotoxin via cross-coupling of transcription factors (In Japanese)

ja: 転写因子クロスカップリングを介した内毒素によるアクアポリン5の発現抑制

en: Seikagaku

ja: 生化学


en: International Exchange and Internationalization in the Graduate School of Oral Scieces and School of Dentistry, the University of Tokushima (in Japanese)

ja: 徳島大学大学院口腔科学教育部ならびに歯学部における国際交流と国際化の推進

en: The Nippon Dental Review

ja: 日本歯科評論


en: Sexual dimorphism and hormonal regulation of granular convoluted tubule (GCT) cells of mouse submandibular gland -Immunohistochemical analysis- (In Japanese)

ja: マウス顎下腺顆粒性導管の性差とホルモンによる調節-免疫組織化学的解析-

en: Journal of Japanese Society for Mastication Science and Health Promotion

ja: 日本咀嚼学会雑誌


en: Structure, function, and transcriptional regulation of aquaporins, proteins of the water channel family

en: Dentistry in Japan

ja: Dentistry in Japan


en: The rodent granular convoluted tubule cell - An update

en: European Journal of Morphology

ja: European Journal of Morphology


en: Processing of the growth factor precursors by kallikreins (in Japanese)

ja: カリクレインによる成長因子前駆体のプロセッシング


en: Expression of EGF and related proteinases in the salivary gland (in Japanese)

ja: EGFおよび関連プロテアーゼの唾液腺における発現


en: Effects of mastication on salivary bioactive substances (in Japanese)

ja: 咀嚼系の唾液腺生理活性因子に対する影響


en: The Biologically active substances and the cells which produce them in the salivary gland -Recent progress regarding the development and biochemistry- (in Japanese)

ja: 唾液腺の生理活性物質とその産生細胞-発生と生化学に関する最近の知見

en: Journal of Clinical and Experimental Medicine

ja: 医学のあゆみ


en: Biologically active substances in the salivary gland (in Japanese)

ja: 唾液腺の生理活性物質

en: Japanese Journal of Oral Biology

ja: 日本歯科基礎医学会誌


en: Studies on molecular level reaction mechanism of photosynthetic ATP formation by solubilization of chromatophore membrane (in Japanese)

ja: クロマトホァ膜の光リン酸化系の可溶化による分子レベル反応メカニズムの研究

en: Protein, Nucleic Acid and Enzymes, supplemented volume 2

ja: 別冊蛋白質核酸酵素，生体膜実験法(下)


en: Preparation of chromatophores from photosynthetic bacteria (in Japanese)

ja: クロマトフォアの調製法

en: Protein, Nucleic Acid and Enzyme, supplemented

ja: 別冊蛋白質核酸酵素，生体膜実験法(上)


en: Molecular mechanism of expression and regulation of water channel, esp. aquaporins in the exocrine gland

ja: 外分泌腺における水チャネル，特にアクアポリン5の発現と機能調節の分子機構

en: , Report of research project, grant in-aid for scientific research (B)

ja: 平成18年度-平成20年度文部省科学研究費補助金(基盤研究(B))研究成果報告書

misc_type: others


en: Induction of inflammation cytokine and defense system of oral cavity: a trial in regeneration medicine

ja: 唾液腺における炎症性サイトカインの誘導と口腔の防御システム:再生医療への試み

en: Report of research project, Grant-in-Aid for Exploratory Research, Tokushima, Mar. 2006

ja: 平成16年度-平成17年度文部省科学研究費補助金(萌芽研究)研究成果報告書


en: Inflammation by mast cell kininogen and its suppression Development of a new drug

ja: 肥満細胞由来キニノーゲンによる炎症とその抑制 -抗アレルギー新薬の開発-

en: , Report of research project, grant in-aid for scientific research (B)(2)

ja: 平成13年度-平成15年度文部省科学研究費補助金(基盤研究(B)(2))研究成果報告書


en: Production of a salivary gland cell line expressing an aquaporin 5 mutant protein and approach to explore the mechanism for water secretion

ja: アクアポリン5変異蛋白質発現用培養唾液腺細胞の作成と水分泌機構解明へのアプローチ

en: Report of research project, grant in-aid for scientific research (C)(2)

ja: 平成13年度-平成14年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書


en: : Expression and regulation of a water channel, aquaporin, in the exocrine gland

ja: 水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構


en: Molecular mechanism of expression and regulation of water channel proteins aquaporins in the salivary gland cells

ja: 水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構

ja: 平成11年度-平成12年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書


en: A new physiologic function of tissue kallikrein family enzymes and processing of growth factor precursors,

ja: 組織カリクレインファミリーの新しい生理機能と成長因子前駆体のプロセッシング

en: Report of research project, grant in-aid for scientific research (C)(2), 1998 March)

ja: 平成8年度-平成9年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書


en: Analysis of genes for tissue kallikrein family enzymes and processing of growth factor precursors

ja: 組織カリクレイン遺伝子ファミリーの解析と成長因子前駆体のプロセッシング

en: マウス顎下腺に存在する4種の主要な組織カリクレイン(mK22，mK9，mK1，mK13)によるキニン遊離活性，並びにプロレニン変換活性を調べた．mK1は最も強いキニン遊離活性を示し，唾液腺以外にも尿，膵臓，消化管に局在した．この事からmK1はマウスの真性組織カリクレインであることが証明された．またキニノーゲナーゼ活性の弱いmK13は最も強いプロレニン変換活性を示した．

en: Report of research by special budget for education and research (Tokushima University)

ja: 平成7年度教育研究学内特別経費による研究報告書(徳島大学)


en: : Regulation mechanism of EGF receptor functions via P2-purinergic receptors and related signal transduction system

ja: EGF受容体機能のP2プリン受容体並びに関連の細胞内情報伝達系を介した調節機構

en: , Report of research project, grant in-aid for scientific research (C)

ja: 平成4年度-平成6年度文部省科学研究費補助金(一般研究(C))研究成果報告書


en: : Effects of extracellular ATP on Ca2+ and phosphatidylinositol metabolism and modulation of EGF receptor function

ja: 細胞外ATP によるCa++イノシト-ルりん酸代謝EGF受容体の機能変化の研究

en: Report of research project, grant in-aid for scientific research (C)

ja: 昭和62年度-昭和64年度文部省科学研究費補助金(一般研究(C))研究成果報告書


en: Development and differentiation of salivary gland -The hormonal regulation

ja: 唾液腺の発生と分化についての分子生物学的研究

en: Report of research project, grant in-aid for scientific research Collaborated research (A)

ja: 昭和55年度文部省科学研究費補助金(総合研究(A))，分担 報告書


en: : Study on hormone action in the salivary gland

ja: 唾液腺におけるホルモン作用の研究

en: Report of research project, grant in-aid for scientific research (D)

ja: 昭和54年度文部省科学研究費補助金(一般研究(D))報告書


ja: 唾液腺の発生と分化についての分子生物学的研究

ja: 昭和54年度文部省科学研究費補助金(総合研究(A))，分担報告書


en: Study on hormone action in the salivary gland

ja: 唾液腺におけるホルモン作用の研究

en: Report of research project, grant in-aid for scientific research (C), 1979 March)

ja: 昭和53年度文部省科学研究費補助金(一般研究(D))報告書


en: Research in molecular biology of development and differentiation of the salivary gland

ja: 唾液腺の発生と分化についての分子生物学的研究

en: 1979-80 Grant-in-Aid for Co-operative Research (A) Development and differentiation of the salivary gland, esp., hormonal regulation

ja: 昭和54年度-昭和55年度文部省科学研究費補助金(総合研究(A)唾液腺の発生と分化 - とくにホルモンによる調節)研究成果報告書


en: Study on the mechanism of synthesis of androgen-dependent granules in the mouse submandibular gland

ja: マウス顎下腺の男性ホルモン依存性顆粒の合成機構に関する研究

en: Report of research project, grant in-aid for scientific research, -Encouragement of Young Scientists (A) -, 1977 March)

ja: 昭和51年度文部省科学研究費補助金(奨励研究 (A))報告書