type: misc

label: url

en: 肺循環障害と右心不全の病態と治療 -小児心臓病のパラダイムシフト-

ja: 肺循環障害と右心不全の病態と治療 -小児心臓病のパラダイムシフト-

en: Potassium channels play diverse roles in regulating the behavior of pulmonary artery smooth muscle cells. The discovery of KCNK3(TASK1)as a new predisposing gene for pulmonary arterial hypertension(PAH)led to an update in the Nice Classification regarding the genetic origin of PAH. Decreased current via KCNA5(Kv1．5)plays a key role in determining pulmonary arterial tone and vascular remodeling. The transformation of smooth muscle cells causes ion channel switching, such as the loss of BKca(Kca1．1)and the gain of IKca(Kca3．1), in immature proliferative smooth muscle cells and also induces cell migration, proliferation, and apoptosis resistance. We propose OCT as a useful tool in diagnosing pulmonary artery hypertension and may provide helpful information for the pulmonary arterial remodeling process, severity, therapeutic strategy, and prognosis in congenital heart disease.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: Right Ventricular Myocardial Stiffness and Relaxation Components by Kinematic Model-Based Analysis

en: Right ventricle (RV) has frequently been described as the forgotten ventricle in the circulation. However, its importance in various cardiac diseases is now unquestioned. This recognition has led to improved risk stratification and development of algorithms for intervention, which incorporate measurements of RV function as key components of the assessment of many conditions. The diastolic function plays an important role in determining ventricular filling and stroke volume. Abnormal left ventricular (LV) diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. In this review, we define what global RV diastolic function is, and how to measure it. This article indicates the validation of kinematic model parameters for assessing RV diastolic function. J. Med. Invest. 67 : 11-20, February, 2020.

en: The Journal of Medical Investigation : JMI


en: 総説「肺高血圧症の病態と新規治療をカリウムチャネル制御から探る」 日本小児循環器学会雑誌」

en: Potassium channels play diverse roles in regulating the behavior of pulmonary artery smooth muscle cells. In 2013, the discovery of KCNK3 (TASK1) as a new predisposing gene for pulmonary arterial hypertension (PAH) led to an update in the Nice Classification regarding the genetic origin of PAH. Decreased current via KCNA5 (Kv1.5) plays a key role in determining pulmonary arterial tone and vascular remodeling. The transformation of smooth muscle cells causes ion channel switching, such as the loss of BKca (Kca1.1) and the gain of IKca (Kca3.1), in immature proliferative smooth muscle cells and also induces cell migration, proliferation, and apoptosis resistance. Pulmonary smooth muscle cells from PAH patients demonstrate many cellular abnormalities linked to potassium channels. This review summarizes the current knowledge regarding the involvement of potassium channels in the development of PAH and discusses potential treatments to be developed in the near feature.

ja: 肺動脈平滑筋細胞に存在するカリウムチャネルは多彩な種類と機能を有し，多くの生理作用ならびに病態に関与している．肺動脈性肺高血圧症(PAH)においても発症と増悪に深く関与していることが明らかになりつつある．2013年にtwo-pore domainカリウムチャネルの1種であるKCNK3(TASK1)の遺伝子変異がPAHの原因遺伝子であると証明され，第5回肺高血圧国際シンポジウム(ニース国際会議)で追加された．また，PAHでは発症原因にかかわらず，電位依存性カリウムチャネル，特にKCNA5(Kv1.5)の発現低下と活性抑制が認められ，肺動脈収縮と血管リモデリングを促進することが示されている．さらに，平滑筋細胞に認められるカルシウム活性化カリウムチャネルは，形質転換によってBKca(Kca1.1)からIKca(Kca3.1)優位に変化し，平滑筋細胞の遊走の促進，増殖能の亢進，アポトーシスの抑制などに影響を与えている．これら肺血管の収縮とリモデリングへのカリウムチャネルの役割を解明することで，新たな治療戦略が見えてくるものと期待される．

en: Pediatric Cardiology and Cardiac Surgery

ja: 日本小児循環器学会雑誌


en: 単心室症患児の開心術後にフェイススケールを用いて心臓リハビリテーションを試みた1症例

en: Heart

ja: 心臓


en: 第109回 医師国家試験問題解説

ja: 第109回 医師国家試験問題解説

en: 第109回 医師国家試験問題解説

ja: 第109回 医師国家試験問題解説


en: Multidetector Row Computed Tomography Evaluation in Pediatric Heart Diseases -Additional Information to Echocardiography and Conventional Cardiac Catherterization

en: International Journal of Pediatric Research


en: 低酸素換気療法と神経発達障害評価のこれから

ja: 低酸素換気療法と神経発達障害評価のこれから

en: 日本小児循環器学会雑誌


en: Multidector-Row Computed Tomography Evaluation in Congenital Heart Disease Patients - Additional Information to Echocardiology and Conventional Cardiac Characterization

en: Congenital Heart Defects: Etiology, Diagnosis and Treatment


en: 2Dティッシュトラッキング法の小児科領域への応用

ja: 2Dティッシュトラッキング法の小児科領域への応用

en: Medix

ja: Medix