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Tokushima University > Research Clusters > Research Clusters (Prioritized) > 1702006 統合的がん創薬研究クラスター >
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Research Activity

Field of Study

Synthetic Organic Chemistry, ペプチド・タンパク質化学, Chemical Biology

Subject of Study

刺激応答型アミノ酸を基盤とした生命現象解明研究 (organic synthetic chemistry, ペプチド・タンパク質化学, chemical biology)

Book / Paper

Book:

1. Akira Otaka and Akira Shigenaga :
「第I編 ペプチド合成,第二章 ペプチドの液相合成」医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―(平野義明 監修),
CMC Publishing Co.,Ltd., Oct. 2017.
2. Akira Shigenaga, Jun Yamamoto and Akira Otaka :
実験医学増刊号 驚愕の代謝システム メタボロームの階層から解き明かす疾患研究の新たなステージ「生物活性小分子の結合パートナータンパク質を知りたい -リンカー分子を用いたタンパク質精製法-」,
YODOSHA CO., LTD., Sep. 2014.
3. Akira Shigenaga, Jun Yamamoto and Akira Otaka :
遺伝子医学MOOK 21号 最新ペプチド合成技術とその創薬研究への応用, 刺激応答型アミノ酸の開発と生命科学分野への応用,
メディカルドゥ, Apr. 2012.
4. Akira Otaka and Akira Shigenaga :
機能性タンパク質・ペプチドの生体利用,第10章 最近のペプチド・タンパク質の化学合成について,
KENPAKUSHA, May 2010.

Academic Paper (Judged Full Paper):

1. Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor,
Chemistry - A European Journal, Vol.25, 2019.
(DOI: 10.1002/chem.201903572,   Elsevier: Scopus)
2. Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence,
Chemical Communications, Vol.55, 7029-7032, 2019.
(DOI: 10.1039/C9CC03583D,   PubMed: 31140482,   Elsevier: Scopus)
3. Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira :
A photo-activatable peptide mimicking functions of apolipoprotein A-I,
Biological & Pharmaceutical Bulletin, Vol.42, No.6, 1019-1024, 2019.
(DOI: 10.1248/bpb.b19-00114,   PubMed: 31155576,   Elsevier: Scopus)
4. Takahisa Jichu, Tsubasa Inokuma, Keisuke Aihara, Taiki Kohiki, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst,
ChemCatChem, Vol.10, No.16, 3402-3405, 2018.
(Tokushima University Institutional Repository: 111892,   DOI: 10.1002/cctc.201800714)
5. Akira Shigenaga, Naoto Naruse and Akira Otaka :
ProteoFind: A script for finding proteins that are suitable for chemical synthesis,
Tetrahedron, Vol.74, No.19, 2291-2297, 2018.
(Tokushima University Institutional Repository: 111928,   DOI: 10.1016/j.tet.2018.03.030)
6. Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
Direct enantioselective indolylation of peptidyl imine for the synthesis of indolyl glycine-containing peptides,
Heterocycles, Vol.97, No.2, 1269-1287, 2018.
(DOI: 10.3987/COM-18-S(T)86)
7. Hiroshi Inaba, Akihito Uemura, Kazushi Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka and Kazunori Matsuura :
Light-induced propulsion of a giant liposome driven by peptide nanofibre growth,
Scientific Reports, Vol.8, No.1, articlenumber-6243, 2018.
(Tokushima University Institutional Repository: 112429,   DOI: 10.1038/s41598-018-24675-7,   PubMed: 29674666)
8. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Resin-bound crypto-thioester for native chemical ligation,
Organic Letters, Vol.20, No.8, 2449-2453, 2018.
(Tokushima University Institutional Repository: 111890,   DOI: 10.1021/acs.orglett.8b00795)
9. Chiharu Mizuguchi, Mitsuki Nakamura, Naoko Kurimitsu, Takashi Ohgita, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I,
Scientific Reports, Vol.8, No.1, Articlenumber-5497, 2018.
(Tokushima University Institutional Repository: 112401,   DOI: 10.1038/s41598-018-23920-3,   PubMed: 29615818)
10. Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara :
CXCL14 acts as a specific carrier of CpG into dendritic cells and activates Toll-like receptor 9-mediated adaptive immunity,
EBioMedicine, Vol.24, 247-256, 2017.
(DOI: 10.1016/j.ebiom.2017.09.012,   PubMed: 28928016,   Elsevier: Scopus)
11. Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Chemical synthetic platform for chlorpromazine oligomers that were reported as photo-degradation products of chlorpromazine,
Chemical & Pharmaceutical Bulletin, Vol.65, No.12, 1161-1166, 2017.
(Tokushima University Institutional Repository: 111929,   DOI: 10.1248/cpb.c17-00692,   PubMed: 29199220,   Elsevier: Scopus)
12. Keisuke Aihara, Tsubasa Inokuma, Takahisa Jichu, Zhenjian Lin, Feixue Fu, Kosuke Yamaoka, Akira Shigenaga, David A. Hutchins, Eric W. Schmidt and Akira Otaka :
Cysteine-free intramolecular ligaiton of N-sulfanylethylanilide peptide using 4-mercaptobenzylphosphonic acid: Synthesis of cyclic peptide, trichamide,
Synlett, Vol.28, No.15, 1944-1949, 2017.
(Tokushima University Institutional Repository: 111889,   DOI: 10.1055/s-0036-1589055)
13. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Inside Front Cover: Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology,
Organic & Biomolecular Chemistry, Vol.15, 5240, 2017.
(DOI: 10.1039/C7OB90109G)
14. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology,
Organic & Biomolecular Chemistry, Vol.15, No.25, 5289-5297, 2017.
(Tokushima University Institutional Repository: 111927,   DOI: 10.1039/C7OB00633K)
15. Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga and Akira Otaka :
A convenient method for preparation of -imino carboxylic acid derivatives and application to the asymmetric synthesis of unnatural -amino acid derivative,
Chemical & Pharmaceutical Bulletin, Vol.65, No.6, 573-581, 2017.
(DOI: 10.1248/cpb.c17-00158,   PubMed: 28566650)
16. Shiho Mikawa, Chiharu Mizuguchi, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Naomi Sakashita, Akira Otaka, Kenichi Akaji and Hiroyuki Saito :
Heparin promotes fibril formation of the N-terminal fragment of amyloidogenic aplipoprotein A-I,
FEBS Letters, Vol.590, 3492-3500, 2016.
(DOI: 10.1002/1873-3468.12426,   PubMed: 27654470,   Elsevier: Scopus)
17. Mitsuhiro Eto, Naoto Naruse, Kyohei Morimoto, Kosuke Yamaoka, Kohei Sato, Kohei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of an anilide-type scaffold for the thioester precursor N-sulfanylethylcoumarinyl amide,
Organic Letters, Vol.18, No.17, 4416-4419, 2016.
(Tokushima University Institutional Repository: 111879,   DOI: 10.1021/acs.orglett.6b02207,   PubMed: 27529363)
18. Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka :
Back Cover: Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library,
ChemBioChem, Vol.17, No.20, 1994, 2016.
(DOI: 10.1002/cbic.201600521)
19. Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka :
Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library,
ChemBioChem, Vol.17, No.20, 1986-1992, 2016.
(Tokushima University Institutional Repository: 111880,   DOI: 10.1002/cbic.201600400,   PubMed: 27428709,   Elsevier: Scopus)
20. Masaya Denda, Takuya Morisaki, Taiki Kohiki, Jun Yamamoto, Kohei Sato, Ikuko Sagawa, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide,
Organic & Biomolecular Chemistry, Vol.14, 6244-6251, 2016.
(Tokushima University Institutional Repository: 111885,   DOI: 10.1039/C6OB01014H)
21. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kouji Itou, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
An N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins,
Chemical Communications, Vol.52, 6911-6913, 2016.
(Tokushima University Institutional Repository: 111925,   DOI: 10.1039/C6CC01229A)
22. Tatsuhiko Shimizu, Rin Miyajima, Naoto Naruse, Kosuke Yamaoka, Keisuke Aihara, Akira Shigenaga and Akira Otaka :
Facile preparation of peptides with C-terminal N-alkylamide via radical-initiated dethiocarboxylation,
Chemical & Pharmaceutical Bulletin, Vol.64, No.4, 375-378, 2016.
(Tokushima University Institutional Repository: 111926,   DOI: 10.1248/cpb.c15-01025,   PubMed: 27039836,   Elsevier: Scopus)
23. Yuki Haraya, Ryo Nadai, Hitoshi Kimura, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Kohsaku Kawakami, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito :
Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1858, No.6, 1339-1349, 2016.
(DOI: 10.1016/j.bbamem.2016.03.021,   PubMed: 27003128,   Elsevier: Scopus)
24. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki :
Identification of SNAIL1 Peptide-Based Irreversible Lysine Specific Demethylase 1-Selective Inactivators,
Journal of Medicinal Chemistry, Vol.59, No.4, 1531-1544, 2016.
(DOI: 10.1021/acs.jmedchem.5b01323,   PubMed: 26700437)
25. Tatsuhiko Shimizu, Rin Miyajima, Kohei Sato, Ken Sakamoto, Naoto Naruse, Miku Kita, Akira Shigenaga and Akira Otaka :
Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides,
Tetrahedron, Vol.72, 992-998, 2016.
(Tokushima University Institutional Repository: 111924,   DOI: 10.1016/j.tet.2015.12.070)
26. Hirokazu Kariyazono, Ryo Nadai, Rin Miyajima, Yuki Haraya, Teruhiko Baba, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide,
Journal of Peptide Science, Vol.22, No.2, 116-122, 2016.
(DOI: 10.1002/psc.2847,   PubMed: 26780967,   Elsevier: Scopus)
27. Chiaki Komiya, Keisuke Aihara, Kou Morishita, Hao Ding, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of an intein-inspired amide cleavage chemical device,
The Journal of Organic Chemistry, Vol.81, No.2, 699-707, 2016.
(Tokushima University Institutional Repository: 111896,   DOI: 10.1021/acs.joc.5b02399,   PubMed: 26646813)
28. Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot/sequential native chemical ligation using photo-caged crypto-thioester,
Organic Letters, Vol.18, No.3, 596-599, 2016.
(DOI: 10.1021/acs.orglett.5b03661,   PubMed: 26753720)
29. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka :
Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis,
Biopolymers, Vol.106, No.4, 531-546, 2015.
(Tokushima University Institutional Repository: 111898,   DOI: 10.1002/bip.22757,   PubMed: 26501985)
30. Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes,
The Journal of Biological Chemistry, Vol.290, No.34, 20947-20959, 2015.
(DOI: 10.1074/jbc.M115.664227,   PubMed: 26175149)
31. Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation,
Bioorganic & Medicinal Chemistry, Vol.23, No.17, 5909-5914, 2015.
(DOI: 10.1016/j.bmc.2015.06.064,   PubMed: 26187016,   Elsevier: Scopus)
32. Miku Kita, Jun Yamamoto, Takuya Morisaki, Chiaki Komiya, Tsubasa Inokuma, Licht Miyamoto, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka :
Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide,
Tetrahedron Letters, Vol.56, No.28, 4228-4231, 2015.
(Tokushima University Institutional Repository: 111909,   DOI: 10.1016/j.tetlet.2015.05.060,   Elsevier: Scopus)
33. Deokho Jung, Kohei Sato, Kyougmi Min, Akira Shigenaga, Juyeon Jung, Akira Otaka and Youngeun Kwon :
Photo-triggered fluorescent labelling of recombinant proteins in live cells,
Chemical Communications, Vol.51, No.47, 9670-9673, 2015.
(DOI: 10.1039/C5CC01067E,   PubMed: 25977944,   Elsevier: Scopus)
34. Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Naoto Naruse, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka :
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate,
Chemical Communications, Vol.51, No.49, 9946-9948, 2015.
(Tokushima University Institutional Repository: 111882,   DOI: 10.1039/C5CC02967H,   PubMed: 26006093,   Elsevier: Scopus)
35. Keisuke Aihara, Tsubasa Inokuma, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
Synthesis of lactam-bridged cyclic peptides by using olefin metathesis and diimide reduction,
Tetrahedron, Vol.71, No.24, 4183-4191, 2015.
(Tokushima University Institutional Repository: 111884,   DOI: 10.1016/j.tet.2015.04.093,   Elsevier: Scopus)
36. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Development of chemical methodology for preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system,
ChemistryOpen, Vol.4, No.4, 448-452, 2015.
(Tokushima University Institutional Repository: 111883,   DOI: 10.1002/open.201500086,   Elsevier: Scopus)
37. Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura :
Inside Back Cover: A photoinduced growth system of peptide nanofibres addressed by DNA hybridization,
Chemical Communications, Vol.51, No.38, 8197, 2015.
(DOI: 10.1039/C5CC90206A)
38. Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura :
A photoinduced growth system of peptide nanofibres addressed by DNA hybridization,
Chemical Communications, Vol.51, No.38, 8020-8022, 2015.
(DOI: 10.1039/c5cc01452b,   PubMed: 25778790,   Elsevier: Scopus)
39. Yuki Haraya, Kento Tanaka, Kohei Tsuji, Yasuo Asami, Hironori Izawa, Akira Shigenaga, Akira Otaka, Hiroyuki Saito and Kohsaku Kawakami :
Molecular Complex Composed of -Cyclodextrin-Grafted Chitosan and pH-Sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux under Acidic pH,
Bioconjugate Chemistry, Vol.26, No.3, 572-581, 2015.
(DOI: 10.1021/acs.bioconjchem.5b00037,   PubMed: 25705984,   Elsevier: Scopus)
40. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
Liquid-phase synthesis of bridged peptides using olefin metathesis of protected peptide with long aliphatic chain anchor,
Organic Letters, Vol.17, No.3, 696-699, 2015.
(Tokushima University Institutional Repository: 111891,   DOI: 10.1021/ol503718j,   PubMed: 25629979,   Elsevier: Scopus)
41. Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker,
Tetrahedron, Vol.70, No.34, 5122-5127, 2014.
(Tokushima University Institutional Repository: 111908,   DOI: 10.1016/j.tet.2014.05.110,   Elsevier: Scopus)
42. Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins,
Organic & Biomolecular Chemistry, Vol.12, No.23, 3821-3826, 2014.
(Tokushima University Institutional Repository: 111911,   DOI: 10.1039/C4OB00622D,   PubMed: 24806338,   Elsevier: Scopus)
43. Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein,
Bioorganic & Medicinal Chemistry, Vol.22, No.11, 2984-2991, 2014.
(Tokushima University Institutional Repository: 111910,   DOI: 10.1016/j.bmc.2014.04.002,   PubMed: 24768166,   Elsevier: Scopus)
44. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto and Akira Otaka :
Examination of native chemical ligation using peptidyl prolyl thioester,
Chemical Communications, Vol.50, No.1, 58-60, 2014.
(DOI: 10.1039/C3CC47228K,   PubMed: 24195110,   Elsevier: Scopus)
45. Emi Adachi, Asako Kosaka, Kohei Tsuji, Chiharu Mizuguchi, Hiroyuki Kawashima, Akira Shigenaga, Kohjiro Nagao, Kenichi Akaji, Akira Otaka and Hiroyuki Saito :
The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils.,
FEBS Letters, Vol.588, No.3, 389-394, 2013.
(DOI: 10.1016/j.febslet.2013.11.031,   PubMed: 24316228)
46. Kosuke Tanegashima, Kohei Tsuji, Kenji Suzuki, Akira Shigenaga, Akira Otaka and Takahiko Hara :
Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors,
FEBS Letters, Vol.587, No.23, 3770-3775, 2013.
(DOI: 10.1016/j.febslet.2013.10.017,   PubMed: 24161674,   Elsevier: Scopus)
47. Kohei Sato, Akira Shigenaga, Keisuke Kitakaze, Ken Sakamoto, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Chemical synthesis of biologically active monoglycosylated GM2-activator protein analog using N-sulfanylethylanilide peptide,
Angewandte Chemie International Edition, Vol.52, No.30, 7855-7859, 2013.
(DOI: 10.1002/anie.201303390,   PubMed: 23765733,   Elsevier: Scopus)
48. Kosuke Tanegashima, Kenji Suzuki, Yuki Nakayama, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara :
CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis,
FEBS Letters, Vol.587, No.12, 1731-1735, 2013.
(DOI: 10.1016/j.febslet.2013.04.046,   PubMed: 23669361)
49. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka :
Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation,
The Journal of Organic Chemistry, Vol.77, No.16, 6948-6958, 2012.
(DOI: 10.1021/jo3011107,   PubMed: 22816612)
50. Keiji Ogura, Akira Shigenaga, Koji Ebisuno, Hiroko Hirakawa and Akira Otaka :
Fmoc-based solid phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives,
Tetrahedron Letters, Vol.53, No.27, 3429-3432, 2012.
(DOI: 10.1016/j.tetlet.2012.04.063)
51. Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka :
Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells,
ChemBioChem, Vol.13, 968-971, 2012.
(Tokushima University Institutional Repository: 111913,   DOI: 10.1002/cbic.201200141,   PubMed: 22505188)
52. Hao Ding, Akira Shigenaga, Kohei Sato, Ko Morishita and Akira Otaka :
Dual kinetically-controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide,
Organic Letters, Vol.13, No.20, 5588-5591, 2011.
(DOI: 10.1021/ol202316v,   PubMed: 21916452)
53. Akira Shigenaga, Ko Morishita, Keiko Yamaguchi, Hao Ding, Koji Ebisuno, Kohei Sato, Jun Yamamoto, Kenichi Akaji and Akira Otaka :
Development of UV-responsive catch-and-release system of a cysteine protease model peptide,
Tetrahedron, Vol.67, No.46, 8879-8886, 2011.
(Tokushima University Institutional Repository: 111905,   DOI: 10.1016/j.tet.2011.09.062)
54. Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Yoshitake Sumikawa, Ken Sakamoto and Akira Otaka :
N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide,
ChemBioChem, Vol.12, No.12, 1840-1844, 2011.
(DOI: 10.1002/cbic.201100241,   PubMed: 21739560)
55. Kohei Tsuji, Akira Shigenaga, Yoshitake Sumikawa, Kosuke Tanegashima, Kohei Sato, Keisuke Aihara, Takahiko Hara and Akira Otaka :
Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation,
Bioorganic & Medicinal Chemistry, Vol.19, No.13, 4014-4020, 2011.
(DOI: 10.1016/j.bmc.2011.05.018,   PubMed: 21658958)
56. Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer,
Tetrahedron, Vol.67, No.22, 3984-3990, 2011.
(Tokushima University Institutional Repository: 111907,   DOI: 10.1016/j.tet.2011.04.048)
57. Akira Shigenaga, Jun Yamamoto, Naomi Nishioka and Akira Otaka :
Enantioselective synthesis of stimulus-responsive amino acid via asymmetric -amination of aldehyde,
Tetrahedron, Vol.66, No.37, 7367-7372, 2010.
(Tokushima University Institutional Repository: 111904,   DOI: 10.1016/j.tet.2010.07.033)
58. Yoshimi Nishikawa, Yoshifumi Takahara, Shinichi Asada, Akira Shigenaga, Akira Otaka, Kouki Kitagawa and Takaki Koide :
A structure activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47,
Bioorganic & Medicinal Chemistry, Vol.18, No.11, 3767-3775, 2010.
(DOI: 10.1016/j.bmc.2010.04.054,   PubMed: 20471275)
59. Akira Shigenaga, Jun Yamamoto, Yoshitake Sumikawa, Toshiaki Furuta and Akira Otaka :
Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation responsive peptide,
Tetrahedron Letters, Vol.51, No.21, 2868-2871, 2010.
(Tokushima University Institutional Repository: 111903,   DOI: 10.1016/j.tetlet.2010.03.079)
60. Akira Shigenaga, Yoshitake Sumikawa, Shugo Tsuda, Kohei Sato and Akira Otaka :
Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method,
Tetrahedron, Vol.66, No.18, 3290-3296, 2010.
(DOI: 10.1016/j.tet.2010.03.016)
61. Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiji Ogura, Ko Morishita, Nami Maeda and Akira Otaka :
Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system,
Tetrahedron Letters, Vol.51, No.18, 2525-2528, 2010.
(Tokushima University Institutional Repository: 111901,   DOI: 10.1016/j.tetlet.2010.03.006)
62. Yoshito Fujimoto, Takuma Shiraki, Yuji Horiuchi, Tsuyoshi Waku, Akira Shigenaga, Akira Otaka, Tsuyoshi Ikura, Kazuhiko Igarashi, Saburo Aimoto, Shin-ichi Take and Kosuke Morikawa :
Proline cis/trans isomerase Pin1 regulates peroxisome proliferators-activated receptor g activity through the direct binding to the AF-1 domain,
The Journal of Biological Chemistry, Vol.285, No.5, 3126-3132, 2010.
(DOI: 10.1074/jbc.M109.055095,   PubMed: 19996102)
63. Yoko Yamaki, Akira Shigenaga, Jinglan Li, Yasuyuki Shimohigashi and Akira Otaka :
Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction,
The Journal of Organic Chemistry, Vol.74, No.9, 3278-3285, 2009.
(DOI: 10.1021/jo900135t,   PubMed: 19331368)
64. Yoko Yamaki, Akira Shigenaga, Kenji Tomita, Tetsuo Narumi, Nobutaka Fujii and Akira Otaka :
Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-heterocyclic carbenes (NHCs),
The Journal of Organic Chemistry, Vol.74, No.9, 3272-3277, 2009.
(DOI: 10.1021/jo900134k,   PubMed: 19331367)
65. Shugo Tsuda, Akira Shigenaga, Kiyomi Bando and Akira Otaka :
N→S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives,
Organic Letters, Vol.11, No.4, 823-826, 2009.
(DOI: 10.1021/ol8028093,   PubMed: 19161341)
66. Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiko Yamaguchi and Akira Otaka :
FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides: Influence of amino acid sequence on reaction kinetics,
Tetrahedron, Vol.65, No.11, 2212-2216, 2009.
(Tokushima University Institutional Repository: 111902,   DOI: 10.1016/j.tet.2009.01.063)
67. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka :
Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide,
ChemBioChem, Vol.8, No.16, 1929-1931, 2007.
(Tokushima University Institutional Repository: 111899,   DOI: 10.1002/cbic.200700442,   PubMed: 17899557)
68. Yoshikazu Sasaki, Keiko Yamaguchi, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Development of copper-mediated allylation of c-activated-a,b-unsaturated lactam toward peptide mimetic synthesis,
Tetrahedron Letters, Vol.48, No.18, 3221-3224, 2007.
(DOI: 10.1016/j.tetlet.2007.03.017)
69. Y. Sasaki, Akira Shigenaga, N. Fujii and Akira Otaka :
Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction.,
Tetrahedron, Vol.63, No.9, 2000-2008, 2007.
(DOI: 10.1016/j.tet.2006.12.055)
70. Ichiro Suzuki, Mayuko Takahashi, Akira Shigenaga, Hisao Nemoto and Kei Takeda :
Synthesis and photo DNA-damaging activities of fluoroquinolone analogues,
Tetrahedron Letters, Vol.47, No.35, 6193-6196, 2006.
(DOI: 10.1016/j.tetlet.2006.06.151)
71. Yoshikazu Sasaki, Ayumu Niida, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Stereoselective Synthesis of (Z)-alkene-containing proline dipeptide mimetics,
The Journal of Organic Chemistry, Vol.71, No.13, 4969-4979, 2006.
(DOI: 10.1021/jo0606002,   PubMed: 16776529)
72. Akira Shigenaga, J. Moss, F. Ashley, G. Kaufmann and K. Janda :
Solid-phase synthesis and cyclative cleavage of quorum-sensing depsipeptide analogues by acylphenyldiazene activation,
Synlett, Vol.2006, No.4, 551-554, 2006.
(DOI: 10.1055/s-2006-932468,   Elsevier: Scopus)
73. Yusuke Ohta, Saori Itoh, Akira Shigenaga, Saori Shintaku, Nobutaka Fujii and Akira Otaka :
Cysteine-Derived S-Protected Oxazolidinones: Potential Chemical Devices for the Preparation of Peptide Thioesters,
Organic Letters, Vol.8, No.3, 467-470, 2006.
(DOI: 10.1021/ol052755m,   PubMed: 16435861,   Elsevier: Scopus)
74. Ichiro Suzuki, Shinsaku Uno, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices,
Bioorganic & Medicinal Chemistry Letters, Vol.14, No.11, 2959-2962, 2004.
(DOI: 10.1016/j.bmcl.2004.02.096,   PubMed: 15125968)
75. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne polyamine conjugates,
Tetrahedron Letters, Vol.45, No.9, 1955-1959, 2004.
(DOI: 10.1016/j.tetlet.2003.12.139)
76. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Developments of Enediyne Model Compounds Generating Biradicals with an Enhanced Radical Character Regulation of Triggering Devices,
Heterocycles, Vol.62, No.1, 503-519, 2004.
(CiNii: 80016354293,   Elsevier: Scopus)
77. Ichiro Suzuki, Akira Shigenaga, Atsuo Manabe, Hisao Nemoto and Masayuki Shibuya :
Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds,
Tetrahedron, Vol.59, No.30, 5691-5704, 2003.
(DOI: 10.1016/S0040-4020(03)00903-7)
78. Ichiro Suzuki, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis of enediyne model compounds possessing a cyanohydrin moiety as a triggering device,
Tetrahedron Letters, Vol.43, No.38, 6779-6781, 2002.
(DOI: 10.1016/S0040-4039(02)01529-0,   Elsevier: Scopus)
79. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Acid-catalyzed Cycloaromatization of Enediyne Model Compounds via Enyne-allene Intermediates.,
Heterocycles, Vol.54, No.2, 571-576, 2001.
(CiNii: 40005326987,   Elsevier: Scopus)
80. Ichiro Suzuki, Masakazu Wakayama, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis of Endiyne Model Compounds Producing Toluene Diradicals Possessing a Highly Radical Character via Enyne-allene Intermediates,
Tetrahedron Letters, Vol.41, No.51, 10019-10023, 2000.
(DOI: 10.1016/S0040-4039(00)01788-3,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis,
Peptide Science 2018, 8, 2019.
2. Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Development and application of novel protein labeling reagent "SEAL",
Peptide Science 2018, 104, 2019.
3. Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
Development of anti-cancer peptide based on prohibitin 2,
Peptide Science 2018, 46, 2019.
4. Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka :
Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst,
Peptide Science 2018, 81, 2019.
5. Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka :
Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis,
Peptide Science 2018, 80, 2019.
6. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis,
Peptide Science 2017, 32-33, 2018.
7. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Development of methodology for producing thioesters from naturally occurring peptide sequence,
Peptide Science 2017, 86-87, 2018.
8. Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito :
Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions,
Peptide Science 2016, 141-142, 2017.
9. Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji and Hiroyuki Saito :
Effect of heparin on amyloid fibril formation of apoA-I fragment peptides,
Peptide Science 2016, 149-151, 2017.
10. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki :
Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors,
Peptide Science 2016, 165-166, 2017.
11. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot sequential native chemical ligations using photocaged crypto-thioester,
Peptide Science 2016, 73-74, 2017.
12. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins,
Peptide Science 2016 [PRESTO], 179-181, 2017.
13. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka :
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
Peptide Science 2016, 75-76, 2017.
14. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Intein-inspired amide bond processing device,
EPS Proceedings 2016, 60, 2016.
15. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Second-generation synthetic strategy of GM2-activator protein (GM2AP) analogues applicable to the preparation of a protein library,
EPS Proceedings 2016, 63, 2016.
16. Keisuke Aihara, Kohsuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot/sequential native chemical ligation using photo-responsive crypto-thioester,
EPS Proceedings 2016, 39, 2016.
17. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol,
Peptide Science 2015, 21-22, 2016.
18. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of intein-inspired peptide bond processing device,
Peptide Science 2015, 281-282, 2016.
19. Kohei Tsuji, Kohei Sato, Mitsuhiro Eto, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide (SEAlide) peptide as a versatile intermediate for protein chemical synthesis using native chemical ligation,
Peptide Science 2014, 113-116, 2015.
20. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins,
Peptide Science 2013, 205-206, 2014.
21. Keisuke Aihara, Akira Shigenaga, Daisuke Takahashi and Akira Otaka :
New approach for synthesis of lactam bridged peptides using olefin metathesis on AJIPHASE®,
Peptide Science 2013, 143-144, 2014.
22. Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka :
Development of hydrogen peroxide-responsive amide bond cleavage device,
Peptide Science 2013, 203-204, 2014.
23. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura and Akira Otaka :
Development of chemical protocols for producing peptide thioesters from naturally occurring peptide sequences,
Peptide Science 2013, 157-158, 2014.
24. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto and Akira Otaka :
Application of peptidyl prolyl thioesters to native chemical ligation,
Peptide Science 2013, 93-94, 2014.
25. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
N-Sulfanylethyl anilide linkers as peptide thioester equivalent,
Peptides Across The Pacific, Proceedings of the Twenty-Third American and Sixth International Peptide Symposium, 242-243, 2013.
26. Akira Shigenaga :
Development of stimulus-responsive amino acid and their application to peptide based chemical biology,
Peptide Science 2012, 1-2, 2013.
27. Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka :
Design and synthesis of hypoxia-responsive amino acid which causes peptide bond cleavage in hypoxic cells,
Peptide Science 2012, Vol.2012, 135-136, 2013.
(CiNii: 10031161576)
28. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Convergent chemical synthesis of human GM2 activator protein analog using SEAlide chemistry,
Peptide Science 2012, Vol.2012, 13-14, 2013.
(CiNii: 10031161530)
29. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka :
Synthesis of antagonistic peptide for putative CXCL14 receptor protein and their identification,
Peptide Science 2012, Vol.2012, 31-32, 2013.
(CiNii: 10031161538)
30. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka :
Development of efficient synthetic protocol for Fmoc amino acid-incorporated N-sulfanylethyl-aniline linker as peptide thioester precursor,
Peptide Scinece 2012, Vol.2012, 165-166, 2013.
(CiNii: 10031161586)
31. Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi and Akira Otaka :
Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer,
Peptide Science 2011, 385-386, 2012.
(CiNii: 10030204614)
32. Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka :
Doubly-kinetically controlled proline ligation,
Peptide Science 2011, 133-134, 2012.
(CiNii: 10030204136)
33. Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation,
Peptide Science 2011, 13-14, 2012.
(CiNii: 10030203930)
34. Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide derivative as a peptide thioester equivalent,
Proceedings of the Twenty-Second American Peptide Symposium, 72-73, 2011.
35. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol,
Proceedings of the Twenty-Second American Peptide Symposium, 74-75, 2011.
36. Akira Otaka and Akira Shigenaga :
Development of amide bond cleavage device with application to chemical biology use,
Peptide Science 2010, Vol.2010, No.0, 49, 2011.
(CiNii: 10028237182)
37. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
Synthesis and biological evaluation of CXCL14 and its derivatives,
Peptide Science 2010, Vol.2010, No.0, 182, 2011.
(CiNii: 10028237759)
38. Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Masaya Denda and Akira Otaka :
Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric -amination of aldehyde,
Peptide Science 2010, Vol.2010, No.0, 202, 2011.
(CiNii: 10028237844)
39. Kohei Sato, Shugo Tsuda, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Native chemical ligation using N-peptidyl anilide as crypto-thioester,
Peptide Science 2010, Vol.2010, No.0, 203, 2011.
(CiNii: 10028237853)
40. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation,
Peptide Science 2010, Vol.2010, No.0, 205, 2011.
(CiNii: 10028237863)
41. Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Development of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins,
Peptide Science 2010, Vol.2010, No.0, 232, 2011.
(CiNii: 10028237977)
42. Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka :
Development of stimulus responsive thiol releasing system for controlling activity of cysteine protease,
Peptide Science 2010, Vol.2010, No.0, 290, 2011.
(CiNii: 10028238228)
43. Akira Shigenaga, Yukiko Nishiyama, Nami Maeda and Akira Otaka :
Synthesis of cyclic peptides via on resin-intramolecular native chemical ligation followed by reductive release from resin,
Peptide Science 2009, 147-148, 2010.
44. Akira Shigenaga, Naomi Nishioka, Jun Yamamoto, Hiroko Hirakawa, Yoshitake Sumikawa, Keiko Yamaguchi and Akira Otaka :
Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid,
Peptide Science 2008, 395-396, 2009.
45. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
The application of peptide thioacids to NCL-type sequential condensation of peptide fragments,
Peptide Science 2008, 175-176, 2009.
46. Yoko Yamaki, Akira Shigenaga and Akira Otaka :
Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction,
Peptide Science 2008, 49-50, 2009.
47. Shugo Tsuda, Nami Maeda, Kiyomi Bando, Akira Shigenaga and Akira Otaka :
Synthesis of peptide thioester using N-substituted aniline derivatives,
Peptide Science 2008, 17-18, 2009.
48. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka :
Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide,
Peptide Science 2007, Vol.2007, 97-98, 2008.
(CiNii: 10021906680)
49. Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Regio- and stereoselective synthesis of (Z)-alkene cis-Xaa-Pro dipeptide mimetics,
Peptides 2006, 126-127, 2007.
50. Akira Shigenaga, J. Moss and K. Janda :
New synthetic methodology for synthesis of cyclic depsipeptide employing acylphenyldiazene activation,
Peptide 2005, Vol.2005, 137-138, 2006.
(CiNii: 10017675501)
51. Takashi Tsuji, Yoshikazu Sasaki, Keiko Yamaguchi, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2' reactions,
Peptide Science 2006, 327, 2006.
52. Akira Shigenaga, Saori Shintaku and Akira Otaka :
Development of photo-responsive self-processing peptides,
Peptide Science 2006, 92, 2006.

Review, Commentary:

1. Akira Shigenaga :
Development of chemical biology tools focusing on peptide/amide bond cleavage reaction,
Chemical & Pharmaceutical Bulletin, Vol.in press (Invited Review), May 2019.
(Tokushima University Institutional Repository: 114044)
2. Akira Shigenaga :
Looking Back on Study Abroad at The Scripps Research Institute,
Journal of the Pharmaceutical Society of Japan, Vol.139, No.2, 221-228, Feb. 2019.
(Tokushima University Institutional Repository: 114043,   DOI: 10.1248/yakushi.18-00169-4,   CiNii: 130007599857)
3. Akira Otaka and Akira Shigenaga :
十字路:Native Chemical Ligation法,
Journal of Synthetic Organic Chemistry, Japan, Vol.76, No.1, 66, Jan. 2018.
(DOI: 10.5059/yukigoseikyokaishi.76.66)
4. Akira Otaka and Akira Shigenaga :
天然に学ぶタンパク質合成化学,
Journal of Synthetic Organic Chemistry, Japan, Vol.76, No.1, 45-54, Jan. 2018.
(DOI: 10.5059/yukigoseikyokaishi.76.45)
5. Akira Shigenaga, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma and Akira Otaka :
Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools,
Journal of Peptide Science, Vol.23, 505-513, Aug. 2017.
(Tokushima University Institutional Repository: 111930,   DOI: 10.1002/psc.2961,   PubMed: 28105728)
6. Yusuke Tsuda, Akira Shigenaga, Kouhei Satou, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発,
ケミカルバイオロジー, Vol.9, 7-10, Jun. 2016.
7. Akira Otaka, Kohei Sato and Akira Shigenaga :
Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry,
Topics in Current Chemistry, Vol.363, 33-56, May 2015.
(DOI: 10.1007/128_2014_586,   PubMed: 25467538)
8. Akira Shigenaga and Akira Otaka :
Development of Stimulus-responsive Amino Acids that are Potentially Applicable to Chemical Biology Use,
化学工業(特集 ペプチド化学の新潮流(1)), Vol.65, No.11, 849-856, Nov. 2014.
(Tokushima University Institutional Repository: 111953,   CiNii: 40020243792)
9. Akira Shigenaga :
JSTさきがけ研究紹介「創薬標的の同定・解析を可能とする革新的ツールの創製」,
HBS研究部だより, Vol.21, 5, Oct. 2014.
10. Masaya Denda, Jun Yamamoto, Kouhei Satou, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Yoshiyuki Yoshimura, Aiko Yamauchi and Akira Otaka :
新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究,
ケミカルバイオロジー, Vol.6, 6-9, Jun. 2013.
11. Akira Shigenaga :
平成24年度日本ペプチド学会奨励賞を受賞して,
Peptide Newsletter Japan, Vol.87, 5-7, Jan. 2013.
12. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの創製,
FUSION MATERIALS NEWS, Vol.14, 3, 2013.
13. Akira Shigenaga :
刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開,
Journal of the Pharmaceutical Society of Japan, Vol.132, No.9, 1075-1082, Sep. 2012.
(Tokushima University Institutional Repository: 111943)
14. Akira Otaka, Kohei Sato, Hao Ding and Akira Shigenaga :
One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide,
Chemical Record, Vol.12, No.5, 479-490, Aug. 2012.
(DOI: 10.1002/tcr.201200007,   PubMed: 22927228)
15. Akira Shigenaga :
''化学''でペプチド・タンパク質を操る,
薬学部だより, Vol.10, 4, Jul. 2012.
16. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの開発,
FUSION MATERIALS NEWS, No.6, Feb. 2012.
17. Akira Shigenaga, Kohei Sato and Akira Otaka :
Recent Progress in the Synthetic Methodologies of Peptide Thioesters,
Journal of Synthetic Organic Chemistry, Japan, Vol.68, No.9, 911-919, Sep. 2010.
(DOI: 10.5059/yukigoseikyokaishi.68.911,   CiNii: 10026870593)
18. Akira Shigenaga, Kohei Sato and Akira Otaka :
十字路:セーフティーキャッチリンカー,
Journal of Synthetic Organic Chemistry, Japan, Vol.68, No.9, 973, Sep. 2010.
(DOI: 10.5059/yukigoseikyokaishi.68.973,   CiNii: 130000451315)
19. Akira Shigenaga and Akira Otaka :
磁気浮上を利用した簡便な固相反応モニター法の開発,
Chemical Biology, Vol.2, 13, May 2009.
20. Akira Shigenaga :
ペプチド化学を基盤とした神経変性疾患治療へのアプローチ,
2009年 研究助成(財団法人 国際科学技術財団), 43-44, Mar. 2009.
21. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka :
刺激応答型アミノ酸を利用した核-細胞質シャトルペプチドの開発,
Chemical Biology, Vol.1, No.1, 7-10, May 2008.
22. Akira Shigenaga and Akira Otaka :
[New type of synthetic peptide library for identifying ligand-binding activity].,
Tanpakushitsu Kakusan Koso, Vol.52, No.13 Suppl, 1792-1793, Oct. 2007.
(PubMed: 18051429,   Elsevier: Scopus)
23. Akira Shigenaga :
留学体験記 スクリプス研究所K.D.Janda研の紹介,
PEPTIDE NEWSLETTER JAPAN, Vol.58, Oct. 2005.

Proceeding of International Conference:

1. Naoto Naruse, Daishiroh Kobayashi, Akira Shigenaga and Akira Otaka :
Copper-mediated Ring Opening of Thiazolidine Derivative for Protein Chemical Synthesis,
27th International Society of Heterocyclic Chemistry Congress, Kyoto, Sep. 2019.
2. Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka :
Development of Novel Ring-Opening Reaction of N-Terminal Thiazolidine for Chemical Protein Synthesis,
26th American Peptide Symposium/11th International Peptide Symposium, Monterey, CA, USA, Jun. 2019.
3. Akira Shigenaga, Takuya Morisaki, Taiki Kohiki, Masaya Denda, Tsubasa Inokuma and Akira Otaka :
Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins,
5th International Symposium for Medicinal Sciences, Chiba, Mar. 2019.
4. Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Development and application of novel protein labeling reagent "SEAL",
10th International Peptide Symposium, Kyoto, Dec. 2018.
5. Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka :
Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst,
10th International Peptide Symposium, Kyoto, Dec. 2018.
6. Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
Development of anti-cancer peptide based on prohibitin 2,
10th International Peptide Symposium, Kyoto, Dec. 2018.
7. Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka :
Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis,
10th International Peptide Symposium, Kyoto, Dec. 2018.
8. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis,
10th International Peptide Symposium, Kyoto, Dec. 2018.
9. Yusuke Kato, Nobuo Maita, Taiki Kohiki, Sumire Kurosawa, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Kazuko YORITA, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
Combined approach of computation and enzymology to investigate novel D-amino acid oxidase inhibitors,
The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine and the 28th Hot Spring Harbor Symposium, Fukuoka, Oct. 2018.
10. Tsubasa Inokuma, Nishida Kodai, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine,
35th European Peptide Symposium, Dublin, Ireland, Aug. 2018.
11. Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
Studies on binding molecules to D-amino acid oxidase using computational approaches,
The 12th International Symposium of the Institute Network, Tokyo, Nov. 2017.
12. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-Sulfanylethylanilide-based Traceable Linker for Purification and Selective Labeling of Target Proteins,
American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017.
13. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of methodology for preparation of peptide thioester via on-resin N-S acyl transfer using N-sulfanylethylanilide peptide,
American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017.
14. Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri :
Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells,
The 6th Pharmaceutical Sciences World Congress 2017, Stockholm, May 2017.
15. Koichiro Tsuchiya, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
A limonene-derivative from Sudachi peel activates sirt1 and improves lipid and glucose metabolism in high fat diet-fed mice.,
欧州糖尿病学会, Dec. 2016.
16. Takahiko Hara, Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga and Akira Otaka :
A Novel Function of a CXC-type Chemokine CXCL14 as a Specific Carrier of CpG DNA into Dendritic Cells for Activating Toll-like Receptor 9-mediated Adaptive Immunity,
58th ASH Annual Meeting & Exposition, San Diego, Dec. 2016.
17. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Second-Generation Synthetic Strategy of GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
18. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Intein-inspired Amide Bond Processing Device,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
19. Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
20. Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga :
Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester,
16th Akabori Conference Japanese-German Symposium on Peptide Science, Kobe, May 2016.
21. Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara :
A CXC type chemokine CXCL14 directly binds to CpG-C DNA to activate Toll-like receptor 9 signaling,
Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2), Dresden, May 2016.
22. Licht Miyamoto, 粟飯原 遥奈, Wenting Xu, Meina Jin, 冨田 洋介, 山岡 朋美, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
リモネン誘導体によるsirt1活性化を介した脂質低下作用,
日本肥満学会,アジアオセアニア糖尿病学会, Nagoya, Oct. 2015.
23. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Development of Chemistry-based Protocol for Sequence-dependent Thioesterification,
American Peptide Symposium 2015, Florida, Jun. 2015.
24. Masaya Denda, Takuya Morisaki, Jun Yamamoto, Kohei Sato, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
In Cell Labeling of Target Proteins using ''SEAL-tag'',
American Peptide Symposium 2015, Florida, Jun. 2015.
25. Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
Limonene-derivative Ameliorates Lipid Profiles by Upregulation of Sirt1 Activity and Expression in Cultured Cells and High Fat Diet-Fed Mice,
American diabetes association, Boston, Jun. 2015.
26. Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka :
Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional control,
The 2nd International Symposium on Fusion Materials Program, Tokyo, Nov. 2014.
27. Akira Otaka, Yusuke Tsuda and Akira Shigenaga :
Chemical thioester synthesis applicable to naturally occurring peptide sequence,
15th Akabori Conference Japanese-German Symposium on Peptide Science, Boppard, Sep. 2014.
28. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis,
The 33rd European Peptide Symposium, Sofia, Aug. 2014.
29. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide,
The 33rd European Peptide Symposium, Sofia, Aug. 2014.
30. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Kouji Itou and Akira Otaka :
Development of chemical protocol for preparation of peptide/protein thioesters applicable to naturally occurring sequences,
17th KPPS Annual Symposium, Seoul, Nov. 2013.
31. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
32. Keisuke Aihara, Akira Shigenaga, Daisuke Takahashi and Akira Otaka :
New approach for synthesis of lactam bridged peptides using olefin metathesis on AJIPHASE®,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
33. Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka :
Development of hydrogen peroxide-responsive amide bond cleavage device,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
34. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura and Akira Otaka :
Development of Chemical Protocols for Producing Peptide Thioesters from Naturally Occurring Peptide Sequences, Part 1,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
35. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Rin Miyajima and Akira Otaka :
Development of Chemical Protocols for Producing Peptide Thioesters from Naturally Occurring Peptide Sequences, Part 2,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
36. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda and Akira Otaka :
Application of peptidyl prolyl thioesters to native chemical ligation,
4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
37. Keisuke Aihara, Daisuke Takahashi, Akira Shigenaga and Akira Otaka :
Olefin metathesis approach utilizing AJIPHASE(R) for the synthesis of lactam bridged peptides,
4th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Kobe, Nov. 2013.
38. Ken Sakamoto, Kohei Sato, Akira Shigenaga and Akira Otaka :
Development of practical synthetic method for Fmoc amino acid-incorporated N-sulfanylethyl anilide linker as peptide thioester equivalent,
4th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Kobe, Nov. 2013.
39. Akira Shigenaga :
SEAlide as thioester equivalent for chemical synthesis of proteins,
4th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Kobe, Nov. 2013.
40. Akira Shigenaga :
Development of stimulus-responsive amino acid and its application to chemical biology,
International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sendai, Sep. 2013.
41. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
Application of thiol-responsive amino acid to traceable linker for purification and selective labeling of target protein,
23rd American Peptide Symposium, Hawai'i, Jun. 2013.
42. Keisuke Aihara, Kohei Tsuji, Akira Shigenaga and Akira Otaka :
Ring-closing metathesis approach for the synthesis of Lys-Glu bridged cyclic peptides,
23rd American Peptide Symposium, Hawai'i, Jun. 2013.
43. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Development of efficient synthetic method for N-amino acyl N-sulfanylethyl anilide linkers as peptide thioester equivalent,
23rd American Peptide Symposium, Hawai'i, Jun. 2013.
44. Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
Development of a novel chemical probe that enables selective labeling of proteins,
The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Kyoto, Oct. 2012.
45. Akira Otaka, Kohei Sato, Hao Ding and Akira Shigenaga :
N-Sulfanylethylanilide peptide for peptide engineering,
The Sixth Peptide Engineering Meeting, Atlanta, Oct. 2012.
46. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Chemical synthesis of human GM2 activator protein analog using SEAlide peptide-mediated one-pot multi-fragment condensation,
The 6th Takeda Science Foundation Symposium on PharmaSciences, Suita, Sep. 2012.
47. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka :
Development of novel antagonistic peptide for CXCL14 receptor,
The 6th Takeda Science Foundation Symposium on PharmaSciences, Suita, Sep. 2012.
48. Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka :
Application of Stimulus-responsive Amino Acid to Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins,
8th AFMC International Medicinal Chemistry Symposium, Tokyo, Nov. 2011.
49. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Hao Ding, Masaya Denda, Takahiko Hara and Akira Otaka :
The First Accomplishment of Development of CXCL14 Antagonistic Peptide by Dimerization of CXCL14 Fragment,
8th AFMC International Medicinal Chemistry Symposium, Tokyo, Nov. 2011.
50. Akira Shigenaga, Masaya Denda, Keiji Ogura, Koji Ebisuno and Akira Otaka :
Development of caged nonhydrolyzable phosphoserine and its incorporation into biomineralization-related peptide,
The 1st International Symposium on Fusion Materials Program, Toba, Oct. 2011.
51. Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka :
Design and synthesis of traceable linker for efficient enrichment and specific labeling of target proteins,
22nd American Peptide Symposium, San Diego, Jun. 2011.
52. Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-sulfanylethylanilide derivative as a peptide thioester equivalent,
22nd American Peptide Symposium, San Diego, Jun. 2011.
53. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol,
22nd American Peptide Symposium, San Diego, Jun. 2011.
54. Akira Otaka and Akira Shigenaga :
Development of amide bond cleavage device with application to chemical biology use,
5th International Peptide Symposium, Kyoto, Dec. 2010.
55. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
Synthesis and biological evaluation of CXCL14 and its derivatives,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
56. Kohei Sato, Shugo Tsuda, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Native chemical ligation using N-peptidyl anilide as crypto-thioester,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
57. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
58. Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
59. Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka :
Development of Stimulus Responsive Thiol Releasng System for Controlling Activity of Cysteine Protease,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
60. Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Masaya Denda and Akira Otaka :
Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric -amination of aldehyde,
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010.
61. Akira Otaka and Akira Shigenaga :
Development of peptide bond cleavage device and its application for chemical biology use,
The 13th Akabori Conference, Leipzig, Germany, Sep. 2010.
62. Jun Yamamoto, Akira Shigenaga, Yoshitake Sumikawa, Toshiaki Furuta and Akira Otaka :
Development of near-infrared two-photon excitation responsive peptide bond cleavage device and examination of its photo-reactivity,
3rd Asia-Pacific International Peptide Symposium, Cheju, Nov. 2009.
63. Yoko Yamaki, Akira Shigenaga and Akira Otaka :
Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene,
The 12th Japan-Korea Joint Symposium on Drug Design and Development, Sendai, May 2008.
64. Akira Otaka, Akira Shigenaga, Naomi Nishioka, Daisuke Tsuji and Kouji Itou :
Cleavage of peptide bonds for the preparation of functional peptides,
The 12th Japan-Korea Joint Symposium on Drug Design and Development, Sendai, May 2008.
65. Takashi Tsuji, Yoshikazu Sasaki, Keiko Yamaguchi, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2' reactions,
43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting, Yokohama, Nov. 2006.
66. Akira Shigenaga, Saori Shintaku and Akira Otaka :
Development of Photo-responsive Self-processing Peptides,
43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting, Yokohama, Nov. 2006.
67. Akira Otaka, Yusuke Ohta, Akira Shigenaga and Nobutaka Fujii :
Development of Chemical Devices for Chemical Ligations,
The 11th Akabori Conference, Kloster Banz, Germany, Oct. 2006.
68. Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Regio- and Stereoselective Synthesis of (Z)-Alkene cis-Xaa-Pro Dipeptide Mimetics with Organocopper-mediated Anti-SN2' Reactions,
29th European Peptide Symposium, Gdansk, Sep. 2006.
69. Akira Shigenaga, Saori Shintaku and Akira Otaka :
Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid,
29th European Peptide Symposium, Gdansk, Sep. 2006.
70. Akira Shigenaga, Saori Shintaku and Akira Otaka :
Development of Photo-triggered Self-processing Peptides,
ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Jul. 2006.
71. Yoshikazu Sasaki, Ayumu Niida, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka :
Synthesis of (Z)-alkene-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides,
The 11th Korea-Japan Joint Symposium On Drug Design and Development, Cheju, May 2006.
72. Akira Otaka, Yusuke Ohta, Akira Shigenaga and Nobutaka Fujii :
Preparation of peptide thioester utilizing S-protected oxazolidinone derived from systeine,
The 11th Korea-Japan Joint Symposium On Drug Design and Development, Cheju, May 2006.
73. Ichiro Suzuki, Akira Shigenaga, Yuki Mitami, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne polyamine conjugates,
Pharmaceutical Sciences World Congress, Kyoto, May 2004.

Proceeding of Domestic Conference:

1. Tsubasa Inokuma, Kohdai Nishida, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Chiral Phosphoric Acid-Catalyzed Asymmetric Mannich-Type Reaction Using Imino Peptide as Substrate,
第12回 有機触媒シンポジウム, Dec. 2019.
2. 種子島 幸祐, 三井 貴洋, 岩瀬 璃奈, Naoto Naruse, Akira Shigenaga, Akira Otaka and 原 孝彦 :
CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム,
第42回日本分子生物学会年会, Dec. 2019.
3. 中川 美帆, 種子島 幸祐, 三井 貴洋, Naoto Naruse, Akira Shigenaga, Akira Otaka, 佐久間 啓 and 原 孝彦 :
ケモカイン CXCL14の脳内ミクログリアに対する働き,
第42回日本分子生物学会年会, Dec. 2019.
4. Sayuki Arii, Masahiro Ueda, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira :
プロテインノックダウン法を用いたチミジル酸合成酵素分解誘導剤開発,
第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2019.
5. Takuya Sakakibara, Tsubasa Inokuma, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
安定なα-イミノリン酸エステルへの触媒的不斉付加を用いるキラルα-アミノリン酸の合成,
第45回反応と合成の進歩シンポジウム, Oct. 2019.
6. Daishiroh Kobayashi, Naoto Naruse, Akira Shigenaga and Akira Otaka :
銅塩を利用するシステインS-保護基除去反応の開発,
第45回反応と合成の進歩シンポジウム, Oct. 2019.
7. Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycine-containing peptide,
第56回ペプチド討論会, Oct. 2019.
8. Daishiroh Kobayashi, Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant,
第56回ペプチド討論会, Oct. 2019.
9. Akira Shigenaga :
創薬標的の同定・解析を可能とする革新的ツールの創製,
2019年度さきがけ疾患代謝領域研究会, Oct. 2019.
10. 浜田 麻衣, Atsushi Nakayama, 中山 慎一朗, Jumpei Teramachi, Daisuke Tsuji, Akira Shigenaga, 安部 正博, Kouji Itou, Akira Otaka and Kosuke Namba :
天然マクロライドの網羅的全合成が拓く新規多発性骨髄腫治療薬の開発研究,
2019年度第2回(第30回)日本プロセス化学会東四国フォーラムセミナー, Oct. 2019.
11. Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, 山次 健三, Akira Shigenaga, 金井 求 and Akira Otaka :
チオール導入型DMAP触媒を利用した環状ペプチド合成法の開発,
第51回若手ペプチド夏の勉強会, Aug. 2019.
12. 浜田 麻衣, 森崎 巧也, Atsushi Nakayama, Jumpei Teramachi, Daisuke Tsuji, Akira Shigenaga, Takenori Yamamoto, Yasuo Shinohara, Akira Otaka, Kouji Itou, 安部 正博 and Kosuke Namba :
天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬,
創薬懇話会2019 in 秋保(仙台), Jun. 2019.
13. Daishiroh Kobayashi, Naoto Naruse, Akira Shigenaga and Akira Otaka :
銅塩を基点とする,タンパク合成を指向した反応開発研究,
創薬懇話会2019 in 秋保, Jun. 2019.
14. Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
がん抑制因子PHB2の部分配列を基盤とした乳がん阻害ペプチドの開発,
創薬懇話会2019 in 秋保, Jun. 2019.
15. Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Development of Novel Methodology for the Synthesis of Non-Proteinogenic Amino Acid-Containing Peptide via Direct Asymmetric Reaction to Peptidyl Substrate,
日本ケミカルバイオロジー学会第14回年会, Jun. 2019.
16. Atsushi Kanayama, Kento Ohkawachi, Taro Shimizu, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira :
腫瘍DDSキャリアとしての人工HDLの調製および動態の評価,
日本薬剤学会第34年会, May 2019.
17. Naoto Naruse, Akira Shigenaga and Akira Otaka :
タンパク質合成を指向したチアゾリジン誘導体の脱保護法の開発,
日本薬学会第139年会, Mar. 2019.
18. Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
がん抑制タンパク質PHB2を基盤とした新規創薬シーズの開発,
日本薬学会第139年会, Mar. 2019.
19. Mai Hamada, Atsushi Nakayama, Akira Shigenaga, Daisuke Tsuji, Jumpei Teramachi, 安部 正博, Kouji Itou, Akira Otaka and Kosuke Namba :
新規Ynone化合物の創生・評価,
日本薬学会第139年会, Mar. 2019.
20. Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Synthesis of indolyl glycine-containing peptide via direct asymmetric reaction to peptide,
日本薬学会第139年会, Mar. 2019.
21. 三井 貴洋, 種子島 幸祐, Naoto Naruse, Akira Shigenaga, Akira Otaka and 原 孝彦 :
CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング,
第41回日本分子生物学会年会, Nov. 2018.
22. 岩瀬 璃奈, Naoto Naruse, 種子島 幸祐, Akira Shigenaga, Akira Otaka and 原 孝彦 :
CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析,
第41回日本分子生物学会年会, Nov. 2018.
23. Sakakibara Takuya, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
24. Takuya Morisaki, Akira Shigenaga and Akira Otaka :
SECmideを基盤としたターンオン型蛍光クリーバブルリンカーの開発,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
25. Masahiro Ueda, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
酵素を利用したチオエステル化反応の効率化を指向したペプチドC末配列の修飾,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
26. Atsushi Kanayama, Keiichiro Okuhira, Kento Ohkawachi, Taro Shimizu, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida :
人工HDLの化学的性状と体内動態への影響に関する検討,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
27. Tsubasa Inokuma, Kazuki Okada, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成,
第44回反応と合成の進歩シンポジウム, Nov. 2018.
28. 中西 雅之, Taiki Kohiki, Akira Shigenaga, Akira Otaka, 田中 信忠, 北出 幸夫, 日野 真美 and 野元 裕 :
S-アデノシルホモシステイン加水分解酵素の蛍光性基質の開発,
第91回日本生化学会大会, Sep. 2018.
29. Masahiro Ueda, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
酵素を利用したチオエステル調製 のためのC末ペプチド配列の最適化,
第50回若手ペプチド夏の勉強会, Aug. 2018.
30. Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
がん 抑制タンパク質PHB2からの創薬シード発掘,
第50回若手ペプチド夏の勉強会, Aug. 2018.
31. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移速度 の向上を指向した新規補助基の開発,
第50回若手ペプチド夏の勉強会, Aug. 2018.
32. Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Akira Shigenaga, 金井 求 and Akira Otaka :
新規チオ ール触媒を利用した分子内ライゲーション法の開発,
第50回若手ペプチド夏の勉強会, Aug. 2018.
33. Takuya Morisaki, Atsushi Nakayama, Kosuke Namba, Akira Shigenaga and Akira Otaka :
トレーサブルリンカー を用いた共有結合性低分子の標的同定,
第50回若手ペプチド夏の勉強会, Aug. 2018.
34. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
On-resinチオエス テル化法から得られた知見とその応用,
第50回若手ペプチド夏の勉強会, Aug. 2018.
35. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
加水分解酵素を利用したC末端特異的チオエステル化反応の開発,
第50回若手ペプチド夏の勉強会, Aug. 2018.
36. Takuya Sakakibara, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
安定なイミンを用いたα-アミノリン酸の実用的不斉合成,
創薬懇話会 2018 in 志賀島, Jun. 2018.
37. Kento Ohkawachi, Naoto Naruse, Akira Shigenaga and Akira Otaka :
新規チオール触媒を利用した環状ペプチド合成法の開発,
創薬懇話会 2018 in 志賀島, Jun. 2018.
38. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
発現タンパク質に適用可能な新規チオエステル合成法の開発,
創薬懇話会 2018 in 志賀島, Jun. 2018.
39. Naoki Miyashita, Keiichiro Okuhira, Haruka Kawahara, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida :
動脈硬化治療を指向した光制御型HDL構成ペプチドの開発,
日本薬剤学会第33年会, Jun. 2018.
40. Akira Shigenaga :
タンパク質化学合成用補助基の生命科学研究用ツールへの展開,
第2回「有用物質合成を加速する分子設計の新展開」に関する研究会「生体分子を制御・可視化するケミカルバイオロジー」, May 2018.
41. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
均一修飾タンパク質の合成を指向したタンパク質C末端特異的活性化反応の開発,
日本薬学会第138年会, Mar. 2018.
42. Akira Shigenaga and Akira Otaka :
アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発,
日本薬学会第138年会(シンポジウム 中分子創薬研究のフロンティア), Mar. 2018.
43. Akira Shigenaga :
スクリプス研究所Janda研への留学経験を振り返る,
日本薬学会第138年会(シンポジウム 若手の海外挑戦とそこから学ぶ次世代創薬研究), Mar. 2018.
44. Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
DAO分子表面に結合する阻害分子の計算科学的解析,
2017年度生命科学系学会合同年次大会, Dec. 2017.
45. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis,
第54回ペプチド討論会, Nov. 2017.
46. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Development of methodology for producing thioesters from naturally occurring peptide sequence,
第54回ペプチド討論会, Nov. 2017.
47. Chiharu Mizuguchi, 伊藤 恵理子, Mitsuki Nakamura, 扇田 隆司, 馬場 照彦, Akira Shigenaga, 島内 寿德, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
脂質膜組成によるIowa変異型アポA-Iの線維化制御メカニズムの解明,
膜シンポジウム2017, Nov. 2017.
48. Akira Shigenaga :
アミド結合切断反応を基盤とした生命科学指向型ツールの開発,
第43回反応と合成の進歩シンポジウム, Nov. 2017.
49. Chiaki Komiya, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質C末端特異的活性化反応の開発,
第35回メディシナルケミストリーシンポジウム, Oct. 2017.
50. Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発,
第35回メディシナルケミストリーシンポジウム, Oct. 2017.
51. Mana Yoshino, Licht Miyamoto, Tomomi Yamaoka, Mayu Hosoi, Takuya Morisaki, Keitaroh Anyohji, Akira Shigenaga, Akira Otaka and Koichiro Tsuchiya :
骨格筋培養細胞でのレプチン作用におけるSIRT1の役割,
第56回 中国四国支部学術大会, Oct. 2017.
52. Kento Ohkawachi, Naoto Naruse, Akira Shigenaga and Akira Otaka :
On-resinチオエステル化を利用した環状ペプチド合成法の開発,
第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Oct. 2017.
53. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究,
第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Oct. 2017.
54. 小久保 友絵, 池田 茉莉那, 渡部 匡史, Akira Shigenaga, Akira Otaka and 藤室 雅弘 :
徳島大学化合物ライブラリーを用いた抗ヘルペスウイルス化合物の探索,
第67回日本薬学会近畿支部大会, Oct. 2017.
55. Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質位置選択的修飾を目指したチオエステル調製法の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
56. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチドへの直接的不斉反応を基盤とする非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
57. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応の速度差を利用したライゲーション反応のための新規補助基の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
58. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
創薬懇話会2017 in 加賀, Jul. 2017.
59. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発,
創薬懇話会2017 in 加賀, Jul. 2017.
60. Haruka Kawahara, Keiichiro Okuhira, Naoki Miyashita, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida :
光応答性アポリポタンパク質の開発,
日本薬剤学会第32年会, May 2017.
61. Tsubasa Inokuma, Nishida Koudai, Akira Shigenaga and Akira Otaka :
ペプチドへの直接的不斉反応を基盤とする新規非天然アミノ酸含有ペプチド合成テクノロジーの開発,
日本薬学会第137年会, Mar. 2017.
62. Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito :
アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析,
日本薬学会第137年会, Mar. 2017.
63. Kohdai Nishida, Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
MnO2を用いたα-イミノカルボン酸誘導体の効率的合成法の開発,
日本薬学会第137年会, Mar. 2017.
64. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発,
日本薬学会第137年会, Mar. 2017.
65. Taiki Kohiki, Masaya Denda, 藤川 昴樹, Tsubasa Inokuma, Akira Shigenaga, Kentaro Kogure and Akira Otaka :
N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発,
日本薬学会第137年会, Mar. 2017.
66. Kyohei Morimoto, 山次 建三, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga, 金井 求 and Akira Otaka :
DMAP誘導体を用いた環状ペプチド合成法の開発,
日本薬学会第137年会, Mar. 2017.
67. Naoto Naruse, 津田 修吾, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
効率的タンパク質合成のためのSEAlideペプチドを用いたon-resinチオエステル化法の開発,
日本薬学会第137年会, Mar. 2017.
68. 種子島 幸祐, 高橋 伶奈, 塗谷 秀子, Naoto Naruse, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and 原 孝彦 :
CXCケモカインCXCL14はCpG DNAに結合し,Toll-like receptor 9シグナルを活性化する,
第39回日本分子生物学会年会, Dec. 2016.
69. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
タンパク質位置選択的修飾を指向したチオエステル調製法の開発,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
70. Naoto Naruse, 種子島 幸祐, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga, 原 孝彦 and Akira Otaka :
N-Sulfanylethylanilideペプチドを利用したケモカイン誘導体の合成とToll-like receptor 9の活性化への影響について,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
71. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
SEAlideを基盤とした標的タンパク質精製ツールの開発研究,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
72. 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 :
ヒドラジン構造を持つペプチド性LSD1阻害薬の創製,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
73. Chiharu Mizuguchi, Shiho Mikawa, 馬場 照彦, 島内 寿徳, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
アミロイドーシス変異アポA-I Iowaの脂質膜結合状態の解析,
膜シンポジウム2016, Dec. 2016.
74. Naoto Naruse, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を利用したN-Sアシル転移促進剤の探 索とペプチド合成への応用,
第42回反応と合成の進歩シンポジウム, Nov. 2016.
75. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
76. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
マンノース6リン酸修飾型GM2活性化タンパク質の合成研究,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
77. Keisuke Aihara, Takahisa Jichu, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ケミカルバイオロジー研究を指向した環状ペプチドtrichamideの合成研究,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
78. Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito :
Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions,
第53回ペプチド討論会, Oct. 2016.
79. Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, 大山 浩之, 馬場 照彦, Akira Shigenaga, 島内 寿徳, 小林 典裕, Akira Otaka and Hiroyuki Saito :
Effect of heparin on amyloid fibril formation of apoA-I fragment peptides,
第53回ペプチド討論会, Oct. 2016.
80. 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 :
Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors,
第53回ペプチド討論会, Oct. 2016.
81. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot sequential native chemical ligations using photocaged crypto-thioester,
第53回ペプチド討論会, Oct. 2016.
82. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-sulfanylethylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins,
第53回ペプチド討論会, Oct. 2016.
83. Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Synthetic study of trichamide using Cys-free ligation,
第53回ペプチド討論会, Oct. 2016.
84. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka :
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
第53回ペプチド討論会, Oct. 2016.
85. Keisuke Aihara, Tetsuro Yoshimaru, Masato Komatsu, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka :
Development of stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells,
第53回ペプチド討論会, Oct. 2016.
86. Akira Shigenaga :
N-Sアシル基転移反応を基盤としたタンパク質完全化学合成法の開拓,
有機合成化学協会中国四国支部主催第74回パネル討論会『次世代を切り拓く全合成研究の若い力』, Oct. 2016.
87. Chiharu Mizuguchi, Shiho Mikawa, 馬場 照彦, 島内 寿徳, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito :
Iowa変異型アポA-Iによる脂質膜環境下でのアミロイド線維形成,
第4回日本アミロイド―シス研究会学術集会, Aug. 2016.
88. Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
Cys-free ligationを用いた環状ペプチドTrichamideの合成研究,
第48回若手ペプチド夏の勉強会, Aug. 2016.
89. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
リソソーム移行型GM2活性化タンパク質の合成研究,
第48回若手ペプチド夏の勉強会, Aug. 2016.
90. 松浦 和則, 植村 明仁, 稲葉 央, Taiki Kohiki, Akira Shigenaga and Akira Otaka :
光誘起ペプチド繊維成長による走光性リポソームの創製,
第26回バイオ・高分子シンポジウム, Jul. 2016.
91. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究,
創薬懇話会2016 in 蓼科, Jun. 2016.
92. Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
中分子創薬を指向した環状ペプチドTrichamideの合成研究,
創薬懇話会2016 in 蓼科, Jun. 2016.
93. Taiki Kohiki, Masaya Denda, Takuya Morisaki, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
''SEAL-tag''を基盤とした細胞内での標的タンパク質ラベル化法の開発,
日本ケミカルバイオロジー学会第11回年会, Jun. 2016.
94. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
標的タンパク質精製ツール"SEAlide-based traceable linker"の開発,
日本ケミカルバイオロジー学会第11回年会, Jun. 2016.
95. 松浦 和則, 植村 明仁, 中原 正彦, 古谷 昌大, Akira Shigenaga, Chiaki Komiya and Akira Otaka :
光誘起ペプチドナノファイバー成長の時空間制御,
第65回高分子学会年次学会, May 2016.
96. Ryo Nadai, 武知 佑樹, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito :
アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される,
日本膜学会第38年会, May 2016.
97. Haruka Kawahara, Keiichiro Okuhira, Kouhei Tsuji, Yusuke Tsuda, Kyohei Morimoto, Hitoshi Kimura, Hirokazu Kariyazono, Risa Ohmura, Asato Ichino, Ryo Sugihara, Kazuchika Nishitsuji, Akira Shigenaga, Naomi Sakashita, Akira Otaka and Hiroyuki Saito :
光応答性アボ A-I 模倣ペプチドの開発研究,
日本薬学会第136年会, Mar. 2016.
98. Akira Shigenaga and Akira Otaka :
ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓,
日本薬学会第136年会, Mar. 2016.
99. Takahisa Jichu, Keisuke Aihara, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
環状ペプチドTrichamideの合成研究,
日本薬学会第136年会, Mar. 2016.
100. Mitsuhiro Etoh, Kyohei Morimoto, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体としてのN-sulfanylethylcoumarinylamide (SECmide) の開発及びペプチド合成への応用,
日本薬学会第136年会, Mar. 2016.
101. Takuya Morisaki, Masaya Denda, Takahiro Nakamura, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
標的タンパク質の高効率的同定を可能とする新規リンカー分子の開発研究,
日本薬学会第136年会, Mar. 2016.
102. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
マンノース六リン酸修飾型GM2活性化タンパク質の合成研究,
日本薬学会第136年会, Mar. 2016.
103. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を用いたOne-potタンパク質化学合成法の開発,
日本薬学会第136年会, Mar. 2016.
104. 高橋 伶奈, 種子島 幸祐, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and 原 孝彦 :
ケモカインCXCL14は癌細胞のヘパラン硫酸に高親和性で結合する,
第38回日本分子生物学会年会・第88回日本生化学会大会合同大会, Dec. 2015.
105. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of intein-inspired peptide bond processing device,
第52回ペプチド討論会, Nov. 2015.
106. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol,
第52回ペプチド討論会, Nov. 2015.
107. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
SEAlideを利用した標的タンパク質精製ツール ''トレーサブルリンカー''の開発研究,
第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
108. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
多成分縮合を可能とする光応答型チオエステル等価体の開発,
第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
109. Tsubasa Inokuma, Kazuya Iwamoto, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide (SEAlide)を基盤としたタンパク質-ペプチドコンジュゲーション法の開発,
第41回反応と合成の進歩シンポジウム, Oct. 2015.
110. Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
α-イミノカルボン酸誘導体の効率的合成法の開発と非天然α-アミノ酸合成への応用,
第41回反応と合成の進歩シンポジウム, Oct. 2015.
111. Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka :
非天然型アミノ酸を含むタンパク質の調製を志向したタンパク質完全化学合成法の開拓,
第64回高分子討論会(特定テーマ 融合マテリアルの精密構造制御と機能創製), Sep. 2015.
112. Takahisa Jichu, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チアゾール含有環状ペプチドTrichamideの合成研究,
第三十一回若手化学者のための化学道場, Aug. 2015.
113. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質自己編集システムを範としたアミド結合切断反応の開発,
第三十一回若手化学者のための化学道場, Aug. 2015.
114. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
標的タンパク質の効率的精製および選択的ラベル化を可能とするケミカルツールの開発研究,
第三十一回若手化学者のための化学道場, Aug. 2015.
115. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を利用した多成分One-pot NCL法の開発,
第三十一回若手化学者のための化学道場, Aug. 2015.
116. Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応を基盤としたin cellタンパク質ラベル化法の開発,
第47回若手ペプチド夏の勉強会, Aug. 2015.
117. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Keisuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
標的タンパク質の高効率同定を可能とするケミカルツールの開発研究,
第47回若手ペプチド夏の勉強会, Aug. 2015.
118. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答性補助基を用いた4成分One-pot NCL法の開発,
第47回若手ペプチド夏の勉強会, Aug. 2015.
119. Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応を利用した新規ラベル化試薬の開発,
創薬懇話会2015 in 徳島, Jul. 2015.
120. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
タンパク質半化学合成を指向した配列特異的チオエステル化法の開発,
創薬懇話会2015 in 徳島, Jul. 2015.
121. Akira Otaka, Kohei Sato and Akira Shigenaga :
化学合成によるタンパク質製剤調製への挑戦,
第15回日本蛋白質科学会年会, Jun. 2015.
122. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質誘導体の第二世代化学合成法の確立,
日本ケミカルバイオロジー学会第10回年会, Jun. 2015.
123. Shiho Mikawa, Chiharu Mizuguchi, Kouhei Tsuji, Akira Shigenaga, 島内 寿徳, Akira Otaka and Hiroyuki Saito :
アポA-Iアミロイド線維形成に与える脂質膜とヘパリンの影響,
日本膜学会第37年会, May 2015.
124. 武知 佑樹, Kento Tanaka, Kouhei Tsuji, 麻見 安雄, 井澤 浩則, Akira Shigenaga, Akira Otaka, 川上 亘作 and Hiroyuki Saito :
シクロデキストリン架橋型キトサン-pH応答性ペプチド複合体による細胞コレステロール排出促進作用,
日本膜学会第37年会, May 2015.
125. Shiho Mikawa, Chiharu Mizuguchi, Kouhei Tsuji, 馬場 照彦, Akira Shigenaga, Akira Otaka and Hiroyuki Saito :
アルギニン変異apoA-Iフラグメントのアミロイド線維形成性,
日本薬学会第135年会, Mar. 2015.
126. Kimihito Naruse, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
M6P修飾型GM2APの合成検討,
日本薬学会第135年会, Mar. 2015.
127. Keiji Ogura, Hiroko Hirakawa, Takuya Morisaki, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka :
低酸素環境応答型アミノ酸の開発研究,
日本薬学会第135年会, Mar. 2015.
128. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究,
日本薬学会第135年会, Mar. 2015.
129. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究,
日本薬学会第135年会, Mar. 2015.
130. Miku Kita, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Protein trans-splicingの高速化を指向したN-intein合成法の開発研究,
日本薬学会第135年会, Mar. 2015.
131. Jun Yamamoto, Takuya Morisaki, Miku Kita, Chiaki Komiya, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
標的タンパク質の効率的濃縮および選択的ラベル化を可能とするチオール応答型トレーサブルリンカーの開発,
第32回メディシナルケミストリーシンポジウム, Nov. 2014.
132. Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
133. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
134. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質機能制御を指向したプロテインスプライシング模倣型アミド結合切断反応の開発,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
135. Akira Shigenaga :
刺激応答型アミノ酸の開発と生命科学分野への展開,
2014年日本化学会中国四国支部大会(若手セッション「ペプチド・タンパク質科学における若手研究者の化学的アプローチと今後の展望」), Nov. 2014.
136. 山岡 朋美, Licht Miyamoto, 川崎 彩, 山根 萌, 高橋 梨恵, Keisuke Ishizawa, Rin Miyajima, Akira Shigenaga, Akira Otaka and Koichiro Tsuchiya :
Leptinによる骨格筋培養細胞での代謝制御作用におけるSIRT1の役割,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
137. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kouhei Satou, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
新規タンパク質チオエステル調製法の開発,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
138. Takahiro Nakamura, Akira Shigenaga, Kouhei Satou, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質アナログの第二世代化学合成法の開発研究,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
139. Mitsuhiro Etoh, Masaya Denda, Kouhei Satou, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチドチオエステル調製のためのクマリン型補助基の開発,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
140. Hirokazu Kariyazono, Wataru Shimmura, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Hiroyuki Saito :
DESIGN OF NANODISC SCAFFOLD PEPTIDE (NSP),
第51回ペプチド討論会, Oct. 2014.
141. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Preparation of Peptide/protein Thioesters Using a Chemical Protocol Applicable to Expressed Proteins.,
51th The Japanese Peptide Society, Oct. 2014.
142. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters using N-sulfanylethylcoumarinylamide peptide,
第51回ペプチド討論会, Oct. 2014.
143. Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide,
第51回ペプチド討論会, Oct. 2014.
144. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein,
51th The Japanese Peptide Society, Oct. 2014.
145. Kazunori Matsuura, Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya and Akira Otaka :
光切断により誘起されるペプチドナノファイバー成長システムの創製,
第63回高分子討論会, Sep. 2014.
146. Kohei Tsuji, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
二量体化したCXCL14 C端側領域はCXCL12アンタゴニストとなる,
第46回若手ペプチド夏の勉強会, Aug. 2014.
147. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Takahiro Nakamura, Tsubasa Inokuma and Akira Otaka :
新規タンパク質チオエステル調製法 ''SQAT system'' の開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
148. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
第二世代hGM2AP完全化学合成法の開発研究,
第46回若手ペプチド夏の勉強会, Aug. 2014.
149. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
150. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
アスパラギン誘導体を用いたインテイン模倣型ペプチド結合切断システムの開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
151. Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
天然型アミノ酸配列からのチオエステル合成,
第46回若手ペプチド夏の勉強会, Aug. 2014.
152. Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
SEAlideを基盤としたトレーサブルリンカーの開発研究,
第46回若手ペプチド夏の勉強会, Aug. 2014.
153. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発,
創薬懇話会2014, Jul. 2014.
154. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発,
日本ケミカルバイオロジー学会第9回年会, Jun. 2014.
155. Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Licht Miyamoto, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka :
過酸化水素応答型ペプチド結合切断デバイスの開発研究,
日本ケミカルバイオロジー学会第9回年会, Jun. 2014.
156. Masato Moriguchi, Masahiro Furutani, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura :
光切断によりβ-シート繊維成長するアニオン性ペプチドの分子設計,
第63回高分子学会年次大会, May 2014.
157. Emi Adachi, Kouhei Tsuji, 川島 浩之, Akira Shigenaga, Kohjiro Nagao, 赤路 健一, Akira Otaka and Hiroyuki Saito :
フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定,
日本薬学会第134年会, Mar. 2014.
158. Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
SEAlideペプチドを用いたCXCL14のone-pot化学合成法の開発,
日本薬学会第134年会, Mar. 2014.
159. Akira Otaka and Akira Shigenaga :
インテインに学ぶ標的タンパク質研究手法の開発,
日本薬学会第134年会, Mar. 2014.
160. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
GM2活性化タンパク質の収束的合成研究,
日本薬学会第134年会, Mar. 2014.
161. Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
ラベル化試薬"SEAL-tag"の開発とCOX-1およびhCA1のラベル化,
日本薬学会第134年会, Mar. 2014.
162. Ysuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
発現タンパク質に適用可能な新規タンパク質チオエステル合成法の開発,
日本薬学会第134年会, Mar. 2014.
163. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発,
日本薬学会第134年会, Mar. 2014.
164. Chiaki Komiya, Jun Yamamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
還元的N-N結合切断反応の改良を基盤とした刺激応答型アミノ酸の実用的合成法の検討,
日本薬学会第134年会, Mar. 2014.
165. Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
天然アミノ酸配列に適用可能な新規ペプチドチオエステル合成法の開発,
日本薬学会第134年会, Mar. 2014.
166. Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Youichi Sato, Tsubasa Inokuma, Aiko Yamauchi and Akira Otaka :
標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発,
日本薬学会第134年会, Mar. 2014.
167. Masahiro Furutani, Kazunori Matsuura, Akira Shigenaga, Chiaki Komiya and Akira Otaka :
光切断によりナノファイバー成長誘起されるペプチド分子システムの創製,
日本化学会第94春季年会, Mar. 2014.
168. Kohei Sato, Masaya Denda, Jun Yamamoto, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
タンパク質機能解明を指向した新規ラベル化試薬''SEAL-tag''の開発研究,
第31回メディシナルケミストリーシンポジウム, Nov. 2013.
169. Keisuke Aihara, Akira Shigenaga and Akira Otaka :
オレフィンメタセシスを用いたGlu-Lys架橋ペプチド新規合成法の開発研究,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013.
170. Koji Ebisuno, Masaya Denda, Keiji Ogura, Akira Shigenaga and Akira Otaka :
ケージド非水解性リン酸化アミノ酸含有ペプチドの合成法の確立と14-3-3βタンパク質への結合能の評価,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013.
171. Chiaki Komiya, Jun Yamamoto, Akira Shigenaga and Akira Otaka :
刺激応答型アミノ酸の実用的合成法の開発検討,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013.
172. Tatsuhiko Shimizu, Rin Miyajima, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
SEAlide peptideを用いた簡便なペプチドチオカルボン酸合成法の開発,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013.
173. Akira Shigenaga :
刺激応答型アミノ酸の開発と生命科学分野への応用,
生命分子機能研究会2013学術集会, Sep. 2013.
174. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
標的タンパク質精製・選択的ラベル化ツール''Traceable Linker''の開発研究,
生命分子機能研究会2013学術集会, Sep. 2013.
175. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
リソソーム病治療を指向したGM2活性化タンパク質アナログの完全化学合成,
生命分子機能研究会2013学術集会, Sep. 2013.
176. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
標的タンパク質を釣り上げろ!∼トレーサブルリンカーの開発∼,
第45回若手ペプチド夏の勉強会, Jul. 2013.
177. Keisuke Aihara, Akira Shigenaga and Akira Otaka :
オレフィンメタセシスを用いたLys-Glu架橋ペプチド新規合成法の開発研究,
第45回若手ペプチド夏の勉強会, Jul. 2013.
178. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
SEAlideユニットの効率的合成法の開発とその応用,
第45回若手ペプチド夏の勉強会, Jul. 2013.
179. Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
過酸化水素応答型ペプチド結合切断能を有するアミノ酸の開発,
第45回若手ペプチド夏の勉強会, Jul. 2013.
180. Takahiro Nakamura, Yusuke Tsuda, Kohei Sato, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
NCL法におけるプロリルチオエステルの有用性の検討,
第45回若手ペプチド夏の勉強会, Jul. 2013.
181. Koji Ebisuno, Masaya Denda, 小倉 圭司, Akira Shigenaga and Akira Otaka :
ケージド非水解性リン酸化アミノ酸含有ペプチドの合成と14-3-3βタンパク質への結合能評価,
日本ケミカルバイオロジー学会第8回年会, Jun. 2013.
182. Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
標的タンパク質の精製・選択的ラベル化ツール「トレーサブルリンカー」の開発,
日本薬学会第133回年会, Mar. 2013.
183. Miku Kita, Jun Yamamoto, Koji Ebisuno, Akira Shigenaga and Akira Otaka :
過酸化水素応答型アミノ酸の開発研究,
日本薬学会第133回年会, Mar. 2013.
184. 折原 賢祐, 小林 久剛, 兼松 誠, Masahiro Yoshida, 中村 崇洋, Daisuke Tsuji, Kouji Itou, Akira Shigenaga, Akira Otaka and Kozo Shishido :
Aspergillide Cの活性評価および標的タンパクの探索,
日本薬学会第133年会, Mar. 2013.
185. Jun Yamamoto, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製実験,
第30回メディシナルケミストリーシンポジウム, Nov. 2012.
186. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Hao Ding, Masaya Denda, Takahiko Hara and Akira Otaka :
CXCL14受容体の同定とそのアンタゴニストペプチドの合成,
第30回メディシナルケミストリーシンポジウム, Nov. 2012.
187. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
リソソーム病治療薬を指向したヒトGM2活性化タンパク質誘導体の化学合成と活性評価,
第30回メディシナルケミストリーシンポジウム, Nov. 2012.
188. Koji Ebisuno, Masaya Denda, Keiji Ogura, Taku Terawaki, Akira Shigenaga and Akira Otaka :
ケージド非水解性リン酸化アミノ酸含有ペプチドの合成とタンパク質結合能の評価,
第30回メディシナルケミストリーシンポジウム, Nov. 2012.
189. Masaya Denda, Jun Yamamoto, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
タンパク質選択的ラベル化法の開発研究,
第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会, Nov. 2012.
190. Miku Kita, Jun Yamamoto, Koji Ebisuno, Akira Shigenaga and Akira Otaka :
酸化ストレス応答型アミノ酸の開発研究,
第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会, Nov. 2012.
191. Akira Shigenaga :
Development of stimulus-responsive amino acids and their application to peptide based chemical biology,
第49回ペプチド討論会, Nov. 2012.
192. Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka :
Design and synthesis of hypoxia-responsive amino acid which causes peptide bond cleavage in hypoxic cells,
第49回ペプチド討論会, Nov. 2012.
193. Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka :
Development of efficient synthetic protocol for Fmoc amino acid-incorporated N-sulfanylethyl-aniline linker as peptide thioester precursor,
第49回ペプチド討論会, Nov. 2012.
194. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Convergent chemical synthesis of human GM2 activator protein analog using SEAlide chemistry,
第49回ペプチド討論会, Nov. 2012.
195. Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka :
Synthesis of antagonistic peptide for putative CXCL14 receptor proteins and their identification,
第49回ペプチド討論会, Nov. 2012.
196. Akira Shigenaga and Akira Otaka :
''化学''でペプチド・タンパク質をあやつる,
第28回若手化学者のための化学道場, Sep. 2012.
197. Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka :
4-チオプロリンを用いたDual-kinetic NCL法の開発,
第44回若手ペプチド夏の勉強会, Aug. 2012.
198. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka :
タンパク質完全化学合成∼ケミストによるタンパク質医薬品開発を目指して∼,
第44回若手ペプチド夏の勉強会, Aug. 2012.
199. Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Yoshiyuki Yoshimura, Aiko Yamauchi and Akira Otaka :
新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究,
日本ケミカルバイオロジー学会第7回年会, Jun. 2012.
200. Jun Yamamoto, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka :
フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製法の開発,
日本ケミカルバイオロジー学会第7回年会, Jun. 2012.
201. Ken Sakamoto, Kohei Sato, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
タンパク質化学合成を指向したN-アミノアシルN-置換アニリンリンカーの効率的合成法の開発,
日本薬学会第132回年会, Mar. 2012.
202. Koji Ebisuno, Jun Yamamoto, Akira Shigenaga and Akira Otaka :
新規チオール応答型アミノ酸の合成とDNA放出システムへの展開,
日本薬学会第132回年会, Mar. 2012.
203. Keisuke Aihara, Kohei Tsuji, Hao Ding, Masaya Denda, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
CXCL14・CXCL12デュアルアンタゴニストペプチドの創製,
日本薬学会第132回年会, Mar. 2012.
204. Masaya Denda, Keiji Ogura, Koji Ebisuno, Akira Shigenaga and Akira Otaka :
リン酸化タンパク質の機能解明に向けたケージド非水解性リン酸化アミノ酸含有ペプチドの合成研究,
日本薬学会第132回年会, Mar. 2012.
205. Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka :
4-チオプロリンを用いたNative Chemical Ligation法の開発,
日本薬学会第132回年会, Mar. 2012.
206. Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Akira Shigenaga, Hirokazu Tamamura and Akira Otaka :
フッ化物イオン応答型アミノ酸の開発と標的タンパク質精製ツールへの応用,
日本薬学会第132回年会, Mar. 2012.
207. Akira Shigenaga :
刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
208. Keiji Ogura, Hiroko Hirakawa, Masaya Denda, Akira Shigenaga and Akira Otaka :
AMP化タンパク質の機能解明を指向したペプチド性分子ツールの開発,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
209. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
CXCL14およびその誘導体の効率的合成法の開発と活性評価,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
210. Masaya Denda, Keiji Ogura, Koji Ebisuno, Akira Shigenaga and Akira Otaka :
リン酸化タンパク質の機能解明に向けた紫外線応答型リン酸化アミノ酸誘導体の合成研究,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
211. Ken Sakamoto, Kohei Sato, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
ペプチドチオエステル合成用アニリン型補助基への効率的アミノ酸導入法の開発,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
212. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
タンパク質AMP化の生理学的意義解明を指向した新規分子ツールの開発,
第37回反応と合成の進歩シンポジウム, Nov. 2011.
213. Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka :
4-メルカプトプロリンを用いたペプチドフラグメント縮合法の開発,
第37回反応と合成の進歩シンポジウム, Nov. 2011.
214. Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
タンパク質化学合成を指向したワンポット4成分連続縮合法の開発,
第37回反応と合成の進歩シンポジウム, Nov. 2011.
215. Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka :
Double-kinetically controlled proline ligation,
第48回ペプチド討論会, Sep. 2011.
216. Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi and Akira Otaka :
Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer,
第48回ペプチド討論会, Sep. 2011.
217. Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation,
第48回ペプチド討論会, Sep. 2011.
218. Akira Otaka and Akira Shigenaga :
Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device,
日本生物物理学会第49回年会, Sep. 2011.
219. Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
簡便かつ効率的タンパク質化学合成法の開発,
創薬懇話会2011, Jul. 2011.
220. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
タンパク質AMP化の生理学的意義解明に向けたAMP化アミノ酸誘導体の創製,
創薬懇話会2011, Jul. 2011.
221. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
AMP化タンパク質の機能解明に向けたAMP化アミノ酸誘導体の創製,
日本ケミカルバイオロジー学会第6回年会, May 2011.
222. Daisuke Tsuji, Kentaroh Namba, 浦上 裕行, 辻 耕平, Akira Shigenaga, Akira Otaka, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou :
ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索,
日本薬学会 第131年会, Mar. 2011.
223. Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Keiji Ogura, Masaya Denda and Akira Otaka :
プロリン型触媒を用いた刺激応答型アミノ酸の不斉合成,
日本薬学会年会, Mar. 2011.
224. Jun Yamamoto, Nami Maeda, Tomohiro Tanaka, Masaya Denda, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka :
標的タンパク質の効率的濃縮と同定を指向したトレーサブルリンカーの開発,
日本薬学会年会, Mar. 2011.
225. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
CXCL14およびその誘導体の多様性指向型化学合成とその活性評価,
日本薬学会年会, Mar. 2011.
226. Kohei Sato, Shugo Tsuda, Yoshitake Sumikawa, Kohei Tsuji, Masaya Denda, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
クリプトチオエステル:ネイティブケミカルライゲーションに直接適用可能なペプチドチオエステル等価体,
日本薬学会年会, Mar. 2011.
227. Daisuke Tsuji, 難波 建多郎, 浦上 裕行, Akira Shigenaga, Akira Otaka, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou :
未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会), Dec. 2010.
228. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
AMP化タンパク質の機能解明に向けたフォスファターゼ抵抗性AMP化アミノ酸の創製,
第29回メディシナルケミストリーシンポジウム, Nov. 2010.
229. Jun Yamamoto, Masaya Denda, Nami Maeda, Akira Shigenaga and Akira Otaka :
標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの創製,
第29回メディシナルケミストリーシンポジウム, Nov. 2010.
230. Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka :
ライブラリ構築を志向したCXCL14およびその誘導体の合成と活性評価,
創薬懇話会2010, Nov. 2010.
231. Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka :
システインプロテアーゼの活性調節を指向した機能性分子の開発,
第49回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2010.
232. Jun Yamamoto, Masaya Denda, Nami Maeda, Akira Shigenaga and Akira Otaka :
標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発,
第49回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2010.
233. Kohei Tsuji, Yoko Yamaki, Jun Yamamoto, Akira Shigenaga, Yasuyuki Shimohigashi and Akira Otaka :
Synthesis of fluoroalkene dipeptide isosteres (FADIs) using intramolecular redox reaction with their incorporation into biologically active peptide,
第38回構造活性相関シンポジウム, Oct. 2010.
234. Jun Yamamoto, Nami Maeda, Akira Shigenaga and Akira Otaka :
ターゲットタンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発,
日本ケミカルバイオロジー学会第5回年会, May 2010.
235. Akira Shigenaga and Akira Otaka :
刺激応答型ペプチド結合切断反応を基盤としたペプチド機能制御,
日本薬学会年会, Mar. 2010.
236. Kohei Tsuji, Jun Yamamoto, Yoko Yamaki, Akira Shigenaga and Akira Otaka :
分子内Redox反応を利用したフルオロアルケンジペプチドイソスターの合成とそのα-アルキル化の検討,
日本薬学会年会, Mar. 2010.
237. Kohei Sato, Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka :
N-置換アニリン型補助基の生理活性ペプチド合成への展開,
日本薬学会年会, Mar. 2010.
238. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
AMP化タンパク質の機能解明に向けた非水解性AMP化アミノ酸の創製,
日本薬学会年会, Mar. 2010.
239. Jun Yamamoto, Yoshitake Sumikawa, Akira Shigenaga, Toshiaki Furuta and Akira Otaka :
近赤外二光子励起応答型ペプチドの開発およびその光反応性の測定,
日本薬学会年会, Mar. 2010.
240. Ko Morishita, Keiko Yamaguchi, Akira Shigenaga, Kenichi Akaji and Akira Otaka :
チオールプロテアーゼの機能制御を指向した機能性分子の開発,
日本薬学会年会, Mar. 2010.
241. Jun Yamamoto, Yoko Yamaki, Kohei Tsuji, Akira Shigenaga and Akira Otaka :
分子内Redox反応を利用したフルオロアルケンジペプチドイソスターの合成とクライゼン型転位によるα-アリル化の検討,
創薬懇話会2009, Dec. 2009.
242. Kou Morishita, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka :
チオールプロテアーゼの活性制御を指向した刺激応答型チオール放出システムの開発,
第28回メディシナルケミストリーシンポジウム, Nov. 2009.
243. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
ペプチドチオカルボン酸の効率的合成と新規ペプチドフラグメント縮合法への適用,
第35回反応と合成の進歩シンポジウム, Nov. 2009.
244. Akira Shigenaga, Yukiko Nishiyama, Nami Maeda and Akira Otaka :
Synthesis of cyclic peptides via on resin-intramolecular native chemical ligation followed by reductive release from resin,
第46回ペプチド討論会, Nov. 2009.
245. Akira Shigenaga :
ペプチド・タンパク質機能制御法について考える,
第42回若手ペプチド夏の勉強会, Aug. 2009.
246. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
Efficient synthesis of peptide thioacids and their application to sequential NCL,
ケミカルバイオロジー学会 第4回年会, May 2009.
247. Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka :
The application of a photo-responsive amino acid to caged ceramides,
ケミカルバイオロジー学会 第4回年会, May 2009.
248. Akira Shigenaga, Shugo Tsuda, Yoshitake Sumikawa and Akira Otaka :
Synthesis of peptide thioesters utilizing N-substituted anilide auxiliaries,
ケミカルバイオロジー学会 第4回年会, May 2009.
249. Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiko Yamaguchi and Akira Otaka :
任意の刺激応答型ペプチド結合切断デバイスの反応速度に与えるアミノ酸配列の影響,
日本薬学会年会, Mar. 2009.
250. Nami Maeda, Shugo Tsuda, Sachie Ishizawa, Akira Shigenaga and Akira Otaka :
分子内NCLを利用した環状ペプチド合成法の開発(1),
日本薬学会年会, Mar. 2009.
251. Yukiko Nishiyama, Aki Nakamoto, Akira Shigenaga and Akira Otaka :
分子内NCLを利用した環状ペプチド合成法の開発(2),
日本薬学会年会, Mar. 2009.
252. Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka :
光刺激応答型アミド結合切断反応のケージドセラミド創製への応用,
日本薬学会年会, Mar. 2009.
253. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
蛋白質化学合成を指向した無保護ペプチドフラグメント順次縮合法の開発,
日本薬学会年会, Mar. 2009.
254. Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka :
刺激応答型アミド結合切断デバイスを利用したケージドセラミドの創製,
創薬懇話会2008, Dec. 2008.
255. Jun Yamamoto, Yoshitake Sumikawa, Naomi Nishioka, Akira Shigenaga, Toshiaki Furuta and Akira Otaka :
近赤外二光子励起応答型ペプチド結合切断デバイスの開発,
第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008.
256. Takumi Morishita, Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka :
ペプチド結合切断能を有する側鎖修飾型アスパラギンの開発,
第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008.
257. Nami Maeda, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
N-Sアシルシフトを利用した環状ペプチドライブラリー構築の試み,
第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008.
258. Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka :
光刺激応答型アミド結合切断反応を利用したケージドセラミドの創製,
第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008.
259. Yoko Yamaki, Akira Shigenaga and Akira Otaka :
分子内redox反応を利用したフルオロアルケンジペプチドイソスターの合成,
第34回反応と合成の進歩シンポジウム, Nov. 2008.
260. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
The application of peptide thioacids to NCL-type sequential condensation of peptide fragments,
The 45th Japanese Peptide Symposium, Oct. 2008.
261. Akira Shigenaga, Naomi Nishioka, Jun Yamamoto, Hiroko Hirakawa, Yoshitake Sumikawa, Keiko Yamaguchi and Akira Otaka :
Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid,
The 45th Japanese Peptide Symposium, Oct. 2008.
262. Yoko Yamaki, Akira Shigenaga and Akira Otaka :
Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction,
The 45th Japanese Peptide Symposium, Oct. 2008.
263. Shugo Tsuda, Nami Maeda, Kiyomi Bando, Akira Shigenaga and Akira Otaka :
Synthesis of peptide thioester using N-substituted aniline derivatives,
The 45th Japanese Peptide Symposium, Oct. 2008.
264. Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka :
チオカルボン酸を利用した化学的蛋白質合成法の開発に関する研究,
第24回若手化学者のための化学道場, Sep. 2008.
265. Shugo Tsuda, Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Yoshitake Sumikawa, Kouji Itou and Akira Otaka :
Development of UV irradiation-responsive amino acid with peptide bond cleavage ability and its application to a nucleocytoplasmic shuttle peptide,
第22回内藤コンファレンス, Sep. 2008.
266. Akira Shigenaga, Naomi Nishioka, Jun Yamamoto and Akira Otaka :
任意の刺激応答型ペプチド結合切断デバイスの開発,
日本ケミカルバイオロジー研究会第3回年会, May 2008.
267. Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka :
人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討,
日本薬学会年会, Mar. 2008.
268. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Jun Yamamoto, Shugo Tsuda, Kouji Itou and Akira Otaka :
ペプチド結合切断能を有する光応答型アミノ酸の開発と核-細胞質シャトルペプチドへの応用,
日本薬学会年会, Mar. 2008.
269. Akira Shigenaga, Daisuke Tsuji, Nishioka Naomi, Tsuda Shugo, Kouji Itou and Akira Otaka :
Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide,
第44回ペプチド討論会, Nov. 2007.
270. Keiko Yamaguchi, Takashi Tsuji, Yoshikazu Sasaki, Akira Shigenaga and Akira Otaka :
有機銅試薬を用いたSN2'型アリル化反応の開発とプロリン型ジペプチドイソスターの合成,
第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007.
271. Yoko Yamaki, Yoshitake Sumikawa, Akira Shigenaga and Akira Otaka :
N-ヘテロサイクリックカルベンを利用したフルオロアルケンイソスターの合成,
第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007.
272. Shugo Tsuda, Nami Maeda, Naomi Nishioka, Akira Shigenaga and Akira Otaka :
機能性ペプチドの創製を目指したアミド結合切断法の開発,
第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007.
273. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka :
ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核-細胞質シャトルペプチドへの展開,
第33回反応と合成の進歩シンポジウム, Nov. 2007.
274. Akira Shigenaga, Daisuke Tsuji, Shugo Tsuda, Kouji Itou and Akira Otaka :
Synthesis of a nuclear-cytoplasmic shuttle peptide possessing a stimulus-responsive amino acid,
日本ケミカルバイオロジー研究会 第2回年会, May 2007.
275. 八巻 陽子, Akira Shigenaga, 富田 健嗣, 鳴海 哲夫, 藤井 信孝 and Akira Otaka :
N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成,
日本薬学会年会, Mar. 2007.
276. Akira Shigenaga, 津田 修吾 and Akira Otaka :
外部刺激応答型ペプチドプロセシングデバイスの開発,
日本薬学会年会, Mar. 2007.
277. Akira Shigenaga, 新宅 沙織 and Akira Otaka :
外部刺激応答型ペプチドの合成と外部刺激応答能の検討,
第32回 反応と合成の進歩シンポジウム, Dec. 2006.
278. Akira Shigenaga, 新宅 沙織 and Akira Otaka :
光刺激応答型ペプチドの開発と速度論的検討,
第7回長井長義記念シンポジウム, Sep. 2006.
279. Akira Shigenaga and Akira Otaka :
蛋白質機能の時空間的制御を目指した外部刺激応答型ペプチドの開発,
日本薬学会年会, Mar. 2006.
280. Akira Shigenaga, J. Moss and K. Janda :
New synthetic methodology for synthesis of cyclic depsipeptide employing acylphenyldiazene activation,
第42回ペプチド討論会, Oct. 2005.
281. Akira Shigenaga :
酸化反応をトリガーとした,環状デプシペプチドの新規合成法の開発:スクリプス研究所 K. D. Janda研の研究紹介,
第38回若手ペプチド夏の勉強会, Aug. 2005.
282. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
ポリアミン部位を有するビラジカル生成モデル化合物に関する研究,
日本薬学会 第124年会, Vol.29[P2]I-396, Mar. 2004.
283. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
DNA親和性部位を有するビラジカル生成モデル化合物に関する研究,
日本薬学会 第123年会, Vol.29[P1]I-007, Mar. 2003.
284. 鈴木 一郎, 土屋 優子, Akira Shigenaga, Hisao Nemoto, 中馬 寛 and Masayuki Shibuya :
Ab-initio法を用いたエンジインモデル化合物の分子設計,
第24回 情報科学討論会, Nov. 2001.
285. 鈴木 一郎, Akira Shigenaga, 土屋 優子, Hisao Nemoto and Masayuki Shibuya :
炭素ビラジカルの反応性制御に基づいた低イオン性ビラジカル生成モデルの開発,
有機合成化学協会 第17回化学道場, Jul. 2001.
286. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
10員環含硫エンジインモデル化合物の芳香環化合物,
日本薬学会 第121年会, Vol.30[PA]I-008, Mar. 2001.

Et cetera, Workshop:

1. Akira Shigenaga :
ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓,
名古屋大学大学院生命農学研究科 食品機能化学特別セミナー, Oct. 2015.
2. Kazuya Iwamoto, Tsubasa Inokuma, Ken Sakamoto, Kohei Sato, Akira Shigenaga and Akira Otaka :
NCL法を利用したペプチド–タンパク質コンジュゲーション法の開発研究,
第6回夏の生物系勉強会, Aug. 2015.
3. Akira Shigenaga :
「さきがけ」採択の体験談と申請に向けたアドバイス,
第2回研究推進セミナー-大型競争的資金の獲得にむけて-, Jul. 2015.
4. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドタンパク質の創製,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第11回公開シンポジウム, Jan. 2015.
5. Akira Shigenaga :
Peptide/Protein-based Chemical Biologyのための基盤技術の開発,
第18回スクリプス・バイオメディカルフォーラム, Nov. 2014.
6. Chiaki Komiya, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質機能の時空間的制御を指向したペプチド結合切断能を有する刺激応答型アミノ酸の開発,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第10回 若手スクール, May 2014.
7. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドタンパク質の創製,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第9回公開シンポジウム, May 2014.
8. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドタンパク質の創製,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第8回公開シンポジウム, Jan. 2014.
9. Akira Shigenaga and Akira Otaka :
Development of traceable linker for target identification using N-sulfanylethylanilide unit,
The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Oct. 2013.
10. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドタンパク質の創製,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第7回公開シンポジウム, May 2013.
11. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの創製,
新学術領域研究「融合マテリアル」第6回公開シンポジウム, Jan. 2013.
12. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの創製,
新学術領域研究 若手合同シンポジウム「配位プログラム」×「融合マテリアル」, Dec. 2012.
13. Akira Shigenaga :
''化学''による生命現象制御をめざして,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第5回若手スクール, Nov. 2012.
14. Keisuke Aihara, Akira Shigenaga, Kohei Tsuji, Kohei Sato and Akira Otaka :
タンパク質化学合成を指向した多成分ペプチドフラグメント縮合法の開発,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第5回若手スクール, Nov. 2012.
15. Akira Shigenaga, Jun Yamamoto, Nami Maeda, Youichi Sato, Aiko Yamauchi and Akira Otaka :
標的タンパク質の精製およびラベル化を可能とするトレーサブルリンカーの開発,
新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第2回若手研究者ワークショップ, Oct. 2012.
16. Akira Shigenaga :
刺激応答型アミノ酸を基盤とした生命科学分野へのアプローチ,
生有研シンポジウム, Aug. 2012.
17. Akira Shigenaga :
バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの創製,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第5回公開シンポジウム, Jun. 2012.
18. Akira Shigenaga :
ペプチド高次構造の制御を指向した紫外線応答型保護基の開発,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第4回公開シンポジウム, Jan. 2012.
19. Kohei Sato, Akira Shigenaga and Akira Otaka :
Native chemical ligation (NCL) without using peptide thioester,
14th Peptide Forum, Dec. 2011.
20. Kohei Tsuji, Yoshitake Sumikawa, Akira Shigenaga and Akira Otaka :
Diversity-oriented Synthesis of CXCL14 and Its Derivatives,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
21. Kohei Sato, Shugo Tsuda, Yoshitake Sumikawa, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Native chemical ligation utilizing N-peptidyl anilide auxiliary,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
22. Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka :
Synthesis of nonhydrolyzable AMPylated amino acid mimetics for revealing physiological role of AMPylated protein,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
23. Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka :
Design and synthesis of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
24. Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga and Akira Otaka :
Development of stimulus responsive thiol releasing device for controlling activity of cysteine protease,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
25. Akira Shigenaga and Akira Otaka :
Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application for controlling peptidyl function,
The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010.
26. Akira Shigenaga :
"化学"でペプチド・タンパク質を操る -神経変性疾患治療を目指して-,
日本の薬学,四国の薬学部, Jun. 2010.
27. Akira Shigenaga :
"化学"でペプチド・タンパク質を操る,
第198回やさしい科学技術セミナー, Nov. 2009.
28. Akira Shigenaga and Akira Otaka :
刺激応答型アミノ酸の開発とペプチド機能制御への展開,
第6回HBS月例セミナー, Oct. 2009.

Report:

1. Akira Shigenaga :
活動内容,結果・成果,今後に向けて,
さきがけ研究者向けScience For Society (SciFoS) 平成26年度活動報告書, 12, Jun. 2015.
2. Akira Shigenaga and Daisuke Tsuji :
サンフォード大学薬学部における臨床薬剤師教育システムに関する視察・調査報告書,
医療人GP「医療の現場と直結した薬剤師養成教育の実践」平成20年度活動報告書, 172-179, 2009.
3. Akira Shigenaga :
国際研究集会派遣研究者報告書,
吉田科学技術財団年報, Vol.77, 16-17, 2007.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Development of a stimulus-responsive amino acid that enables functional control of peptides and proteins (Project/Area Number: 15K07858 )
  • バイオミネラリゼーションの時空間的制御を可能とするケージドタンパク質の創製 (Project/Area Number: 25107724 )
  • Development of auxiliaries for ligation of peptides at a site other than cystein (Project/Area Number: 24590010 )
  • Development of synthetic platoform of proteins (Project/Area Number: 24390026 )
  • バイオミネラリゼーションの時空間的制御を可能とするケージドペプチドの創製 (Project/Area Number: 23107523 )
  • Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries (Project/Area Number: 23390026 )
  • Development of a recapturable linker that enables isolation and labeling of target proteins (Project/Area Number: 22790012 )
  • Development of methodologies for catalytic decomposition of proteins (Project/Area Number: 21390031 )
  • Development of nulecytoplasmic shuttlepeptide and its applicatution for controlling distribution of disease related protein (Project/Area Number: 20790012 )
  • Davelopment of methodology for the preparation of membrane proteins (Project/Area Number: 18390006 )
  • Search by Researcher Number (10423394)