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研究活動

専門分野

環境生理学 (Environmental Physiology)

研究テーマ

中枢脂質代謝の睡眠制御における役割

著書・論文

著書:

1. 近久 幸子 :
2章 睡眠のメカニズム,3章 ノンレム・レム期の脳の働き,4章 睡眠リズムの変化のメカニズム,
株式会社 メジカルビュー社, 2014年3月.
2. 近久 幸子, 西野 精治 :
神経伝達物質と睡眠,
株式会社シナジー出版, 2012年6月.

学術論文(審査論文):

1. Yoshitsugu Kondo, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Daisuke Tanioka, Haruo Uguisu and Hiroyoshi Sei :
Sleep profile during fasting in PPAR-alpha knockout mice.,
Physiology & Behavior, 2019.
(DOI: 10.1016/j.physbeh.2019.112760,   PubMed: 31785270)
2. Kazuhiro Muramatsu, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei and Yuichi Inoue :
Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients' sera in a mouse model of restless legs syndrome.,
Scientific Reports, Vol.9, No.1, 2019.
(DOI: 10.1038/s41598-019-52735-z,   PubMed: 31704978)
3. Tetsuya Shiuchi, Takuya Masuda, Noriyuki Shimizu, Sachiko Chikahisa and Hiroyoshi Sei :
Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice.,
The Journal of Physiological Sciences, Vol.69, No.6, 1019-1028, 2019.
(DOI: 10.1007/s12576-019-00722-4,   PubMed: 31664642)
4. Tetsuya Shiuchi, Yumiko Miyatake, Airi Otsuka, Sachiko Chikahisa, Hiroshi Sakaue and Hiroyoshi Sei :
Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice.,
Biochemical and Biophysical Research Communications, Vol.514, No.1, 166-172, 2019.
(DOI: 10.1016/j.bbrc.2019.04.145,   PubMed: 31029425)
5. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
Sufficient intake of high-fat food attenuates stress-induced social avoidance behavior.,
Life Sciences, Vol.219, 219-230, 2019.
(DOI: 10.1016/j.lfs.2019.01.012,   PubMed: 30653972,   Elsevier: Scopus)
6. Sachiko Chikahisa, Daiki Chida, Tetsuya Shiuchi, Saki Harada, Noriyuki Shimizu, Airi Otsuka, Daisuke Tanioka and Hiroyoshi Sei :
Enhancement of fear learning in PPAR knockout mice.,
Behavioural Brain Research, Vol.359, 664--670, 2019.
(DOI: 10.1016/j.bbr.2018.09.020,   PubMed: 30278189)
7. Sachiko Chikahisa, Saki Harada, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Seiji Nishino and Hiroyoshi Sei :
Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.,
Scientific Reports, Vol.7, No.1, 2017.
(徳島大学機関リポジトリ: 112403,   DOI: 10.1038/s41598-017-14162-w,   PubMed: 29057915,   Elsevier: Scopus)
8. Yohei Sagawa, Masatoshi Sato, Noriaki Sakai, Sachiko Chikahisa, Shintaro Chiba, Takashi Maruyama, Junki Yamamoto and Seiji Nishino :
Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.,
Neuropharmacology, Vol.110, No.Pt A, 268-276, 2016.
(DOI: 10.1016/j.neuropharm.2016.07.013,   PubMed: 27474349)
9. Kanna Oura, Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
Late feeding in the active period decreases slow-wave activity.,
Life Sciences, Vol.160, 18-26, 2016.
(DOI: 10.1016/j.lfs.2016.07.005,   PubMed: 27436545)
10. Takeshi Kanda, Natsuko Tsujino, Eriko Kuramoto, Yoshimasa Koyama, A Etsuo Susaki, Sachiko Chikahisa and Hiromasa Funato :
Sleep as a biological problem: an overview of frontiers in sleep research.,
The Journal of Physiological Sciences, Vol.66, No.1, 1-13, 2016.
(DOI: 10.1007/s12576-015-0414-3,   PubMed: 26541158,   Elsevier: Scopus)
11. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice.,
Physiology & Behavior, Vol.151, 264-271, 2015.
(DOI: 10.1016/j.physbeh.2015.07.024,   PubMed: 26232088,   Elsevier: Scopus)
12. Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei :
Ketone body metabolism and sleep homeostasis in mice.,
Neuropharmacology, Vol.79, 399-404, 2014.
(DOI: 10.1016/j.neuropharm.2013.12.009,   PubMed: 24361452,   Elsevier: Scopus)
13. Sachiko Chikahisa, Tohru Kodama, Atsushi Soya, Yohei Sagawa, Yuji Ishimaru, Hiroyoshi Sei and Seiji Nishino :
Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states.,
PLoS ONE, Vol.8, No.10, e78434, 2013.
(DOI: 10.1371/journal.pone.0078434,   PubMed: 24205232)
14. Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Sei and Kazuo Yoshizaki :
The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice,
Neuropharmacology, Vol.72, 58-65, 2013.
(DOI: 10.1016/j.neuropharm.2013.04.009,   PubMed: 23624141,   Elsevier: Scopus)
15. Noriyuki Shimizu, Sachiko Chikahisa, Yuina Nishi, Saki Harada, Yohei Iwaki, Hiroaki Fujihara, Kazuyoshi Kitaoka, Tetsuya Shiuchi and Hiroyoshi Sei :
Maternal Dietary Restriction Alters Offspring's Sleep Homeostasis.,
PLoS ONE, Vol.8, No.5, e64263, 2013.
(DOI: 10.1371/journal.pone.0064263,   PubMed: 23741310,   Elsevier: Scopus)
16. Sachiko Chikahisa and Hiroyoshi Sei :
The role of ATP in sleep regulation.,
Frontiers in Neurology, Vol.2, 87, 2011.
(DOI: 10.3389/fneur.2011.00087,   PubMed: 22207863)
17. P Sergiu Paşca, Thomas Portmann, Irina Voineagu, Masayuki Yazawa, Aleksandr Shcheglovitov, M Anca Paşca, Branden Cord, D Theo Palmer, Sachiko Chikahisa, Seiji Nishino, A Jonathan Bernstein, Joachim Hallmayer, H Daniel Geschwind and E Ricardo Dolmetsch :
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.,
Nature Medicine, Vol.17, No.12, 1657-1662, 2011.
(DOI: 10.1038/nm.2576,   PubMed: 22120178)
18. Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki and Hiroyoshi Sei :
Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice,
Brain Research, Vol.1423, 10-16, 2011.
(DOI: 10.1016/j.brainres.2011.09.023,   PubMed: 22000589)
19. Noriyuki Shimizu, Sachiko Chikahisa, Kazuyoshi Kitaoka, Seiji Nishino and Hiroyoshi Sei :
Refeeding after a 24-hour fasting deepens NREM sleep in a time-dependent manner.,
Physiology & Behavior, Vol.104, No.3, 480-487, 2011.
(DOI: 10.1016/j.physbeh.2011.05.011,   PubMed: 21605579)
20. Noriaki Sakai, Sachiko Chikahisa and Seiji Nishino :
Stimulants in excessive daytime sleepiness,
Sleep Medicine Clinics, Vol.5, No.4, 591-607, 2010.
(DOI: 10.1016/j.jsmc.2010.08.009)
21. E Matthew Carter, Ofer Yizhar, Sachiko Chikahisa, Hieu Nguyen, Antoine Adamantidis, Seiji Nishino, Karl Deisseroth and Luis Lecea de :
Tuning arousal with optogenetic modulation of locus coeruleus neurons.,
Nature Neuroscience, Vol.13, No.12, 1526-1533, 2010.
(DOI: 10.1038/nn.2682,   PubMed: 21037585)
22. Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei :
Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene).,
Neuroscience, Vol.167, No.3, 573-582, 2010.
(DOI: 10.1016/j.neuroscience.2010.01.059,   PubMed: 20138974)
23. Yuta Yamamoto, Toshihito Tanahashi, Tomoko Kawai, Sachiko Chikahisa, Sakurako Katsuura, Kensei Nishida, Shigetada Teshima-Kondo, Hiroyoshi Sei and Kazuhito Rokutan :
Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice.,
Physiological Genomics, Vol.39, No.3, 227-235, 2009.
24. Sachiko Chikahisa, Nobuhiro Fujiki, Kazuyoshi Kitaoka, Noriyuki Shimizu and Hiroyoshi Sei :
Central AMPK contributes to sleep homeostasis in mice,
Neuropharmacology, Vol.57, No.4, 369-374, 2009.
(DOI: 10.1016/j.neuropharm.2009.07.015,   PubMed: 19615388)
25. Kazuyoshi Kitaoka, Kaoru Uchida, Naoko Okamoto, Sachiko Chikahisa, Toshitsugu Miyazaki, Eiji Takeda and Hiroyoshi Sei :
Fermented ginseng improves the first-night effect in humans,
Sleep, Vol.32, No.3, 413-421, 2009.
(PubMed: 19294962)
26. Sachiko Chikahisa, Kumiko Tominaga, Tomoko Kawai, Kazuyoshi Kitaoka, Katsutaka Oishi, Norio Ishida, Kazuhito Rokutan and Hiroyoshi Sei :
Bezafibrate, a PPARs agonist, decreases body temperature and enhances EEG delta oscillation during sleep in mice.,
Endocrinology, Vol.149, No.10, 5262-5271, 2008.
(DOI: 10.1210/en.2008-0285,   PubMed: 18787029)
27. Hiroyoshi Sei, Katsutaka Oishi, Sachiko Chikahisa, Kazuyoshi Kitaoka, Eiji Takeda and Norio Ishida :
Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice.,
Endocrinology, Vol.149, No.7, 3576-3580, 2008.
(DOI: 10.1210/en.2007-1714,   PubMed: 18403480)
28. Miyazaki Koyomi, Wakabayashi Miyuki, Sachiko Chikahisa, Hiroyoshi Sei and Norio Ishida :
PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus,
Genes to Cells, Vol.12, No.11, 1225-1234, 2007.
(DOI: 10.1111/j.1365-2443.2007.01129.x,   PubMed: 17986006)
29. Kazuyoshi Kitaoka, Atsushi Hattori, Sachiko Chikahisa, Ken-ichi Miyamoto, Yutaka Nakaya and Hiroyoshi Sei :
Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice,
Brain Research, Vol.1150, 121-130, 2007.
(DOI: 10.1016/j.brainres.2007.02.077,   PubMed: 17400199)
30. Sachiko Chikahisa, Atsuko Sano, Kazuyoshi Kitaoka, Ken-ichi Miyamoto and Hiroyoshi Sei :
Anxiolytic effect of music depends on ovarian steroid in female mice.,
Behavioural Brain Research, Vol.179, No.1, 50-59, 2007.
(DOI: 10.1016/j.bbr.2007.01.010,   PubMed: 17280725)
31. Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita :
Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults.,
Behavioural Brain Research, Vol.169, No.2, 312-319, 2006.
(DOI: 10.1016/j.bbr.2006.01.021,   PubMed: 16530277)
32. T Wada, H Sei, K Kusumoto, K Kitaoka, Sachiko Chikahisa, K Rokutan and Y Morita :
Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.,
Brain Resesarch Bulletin, Vol.69, No.4, 388-392, 2006.
33. Ryou Urushihara, Nagako Murase, C John Rothwell, Masafumi Harada, Yuki Hosono, Kotaro Asanuma, Hideki Shimazu, Kazumi Nakamura, Sachiko Chikahisa, Kazuyoshi Kitaoka, Hiroyoshi Sei, Yusuke Morita and Ryuji Kaji :
Effect of repetitive transcranial magnetic stimulation applied over the premotor cortex on somatosensory-evoked potentials and regional cerebral blood flow.,
Neuroimage, Vol.31, No.2, 699-709, 2006.
(DOI: 10.1016/j.neuroimage.2005.12.027,   PubMed: 16466934)

総説・解説:

1. 近久 幸子 :
睡眠負債と代謝性疾患,
睡眠医療, Vol.12, 369-373, 2018年.
2. 近久 幸子, 勢井 宏義 :
ヒスタミンと睡眠調節-ヒスタミン神経系とマスト細胞の役割-,
睡眠医療, Vol.10, 35-42, 2016年.
3. 近久 幸子 :
エネルギー代謝におけるマスト細胞の新たな役割,
実験医学, Vol.34, 1276-1277, 2016年.
4. 勢井 宏義, 北岡 和義, 近久 幸子 :
Sleep regulatory mechanisms,
日本臨牀, Vol.70, No.7, 1133-1138, 2012年7月.
(PubMed: 22844794,   Elsevier: Scopus)
5. 近久 幸子, 勢井 宏義 :
睡眠とエネルギー代謝∼核内受容体との関係から∼,
健康開発, Vol.12, No.3, 28-33, 2008年5月.

国際会議:

1. Junhel Dalanon, Sachiko Chikahisa, Noriyuki Shimizu, Arief Waskitho, Hiroyoshi Sei and Yoshizo Matsuka :
Orofacial thermal hyperalgesia in predictable chronic mild stress,
Asian Academy of Orofacial Pain and Temporomandibular Disorders, Manila, Oct. 2019.
2. Junhel Dalanon, Sachiko Chikahisa, S Afroz, Takuma Iwasa, Arief Waskitho, Noriyuki Shimizu, Hiroyoshi Sei and Yoshizo Matsuka :
Chronic mild stress exacerbates sleep quality and pain threshold,
Philippine Dental Association, Manila, May 2019.
3. Tetsuya Shiuchi, Takuya Masuda, Noriyuki Shimizu, Sachiko Chikahisa and Hiroyoshi Sei :
Role of dopaminergic function in septum on exercise efficiency,
FAOSP2019, Mar. 2019.
4. Sachiko Chikahisa, Tetsuya Shiuchi, Tanioka Daisuke, Noriyuki Shimizu, Otsuka Airi and Hiroyoshi Sei :
Chronic mild stress increases aggressive behavior in mice,
FAOPS 2019, Kobe, Mar. 2018.
5. Sachiko Chikahisa, Harada Saki, Noriyuki Shimizu, Tetsuya Shiuchi, Nishino Seiji and Hiroyoshi Sei :
Sleep loss induces diabetes in mice model,
Neuroscience 2016, San Diego, USA, Nov. 2016.
6. Noriyuki Shimizu, Yu Yoshioka, Sachiko Chikahisa, Yuki Kito, Tetsuya Shiuchi and Hiroyoshi Sei :
Short time running exercise enhances sleep pressure in mice.,
Neuroscience 2016, San Diego, USA, Nov. 2016.
7. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa and Hiroyoshi Sei :
Restricted high fat diet can improve social avoidance induced by social-defeat stress as same as ad libitum high fat feeding,
Neuroscience 2016, Nov. 2016.
8. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Junji Terao and Hiroyoshi Sei :
Ingestion of restrickted comfortable food improves social avoidance induced by social defeat stress,
12th Asian Congress of Nutrition, Yokohama, May 2015.
9. Tetsuya Shiuchi, Airi Otuska, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
Feeding rhythm during active phase influences hypothalamic regulation of insulin sensitivity in skeletal muscle,
12th Asian Congress of Nutrition, Yokohama, May 2015.
10. Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei :
Contribution of PPARa and Ketone Body to Sleep Homeostasis in Mice,
The FASEB journal, Boston, Apr. 2015.
11. Tetsuya Shiuchi, Airi Otuska, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
Hypothalamic AgRP-mediated energy metabolism in skeletal muscle is a critical regulatory system in feeding rhythm-induced insulin resistance,
Experimental Biology 2015, Boston, Mar. 2015.
12. Sachiko Chikahisa, Saki Harada, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei :
Sleep quality affects glucose homeostasis in a mouse model,
Homeodynamics in Clocks, Sleep and Metabolism, Tokyo Translational Therapeutics Meeting, Sep. 2014.
13. Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei :
Ketone bodies in the brain regulate sleep homeostasis in mice,
Gordon Research Conference on Sleep Regulation and Function, Galveston, USA, Mar. 2014.
14. Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei :
Ketone bodies regulate sleep homeostasis,
Neuroscience 2013, Nov. 2013.
15. Kanna Oura, Tetsuya Shiuchi, Noriyuki Shimizu, Sachiko Chikahisa and Hiroyoshi Sei :
Effect of feeding rhythm on sleep/wake regulation,
EASD, Sep. 2013.
16. Tetsuya Shiuchi, Sachiko Chikahisa, Kanna Oura, Noriyuki Shimizu and Hiroyoshi Sei :
Different feeding rhythm influences hypothalamic regulation of energy metabolism in skeletal muscle,
EASD, Sep. 2013.
17. Noriyuki Shimizu, Sachiko Chikahisa, Yohei Iwaki, Kazuyoshi Kitaoka and Hiroyoshi Sei :
Male adult mice with low birth weight show an increased sleep pressure,
Sleep 2012: 26th Annual Meeting of the Associated Professional Sleep Societies, Boston, Jun. 2012.
18. Sachiko Chikahisa, Tohru Kodama, Yohoei Sagawa, Yuji Ishimaru, Hiroyoshi Sei and Seiji Nishino :
Effects of icv administration of a mast cell histamine release enhancer on sleep/wake in wild-type and mast cell deficient mice,
Sleep 2012: 26th Annual Meeting of the Associated Professional Sleep Societies, Boston, Jun. 2012.
19. Sachiko Chikahisa, Noriyuki Shimizu, Hiroaki Fujihara, Tetsuya Shiuchi and Hiroyoshi Sei :
Sleep homeostatic regulations in PPAR-knockout mice,
Frontiers in Behavioral Brain Science-Solving the mystery of sleep-, Tokyo, Mar. 2012.
20. Hiroyoshi Sei, Kazuyoshi Kitaoka, Nobuhiro Fujiki, Noriyuki Shimizu, Sachiko Chikahisa, Hiroaki Fujihara, Tetsuya Shiuchi and A Nakai :
Mice lacking heat shock factor 1 show evening-type sleep/wake rhythm,
World sleep 2011, Kyoto, Oct. 2011.
21. Noriyuki Shimizu, Sachiko Chikahisa, Yohei Iwaki, Kazuyoshi Kitaoka and Hiroyoshi Sei :
Low birth weight by undernutrition during pregnancy elicits anxiety and depression in male offspring mice,
World sleep 2011, Kyoto, Oct. 2011.
22. Sachiko Chikahisa, Noriyuki Shimizu, Kazuyoshi Kitaoka, Yohei Iwaki, Hiroaki Fujihara, Tetsuya Shiuchi and Hiroyoshi Sei :
Sleep/wake regulation in PPAR knockout mice,
World sleep 2011, Oct. 2011.
23. Sachiko Chikahisa and Hiroyoshi Sei :
PPARs, AMPK and sleep homeostasis,
36th Japanase Society of Sleep Research-World sleep 2011 (Kyoto, Japan), Oct. 2011.
24. Sachiko Chikahisa, Yohei Sagawa, Yuji Ishimaru, Noriaki Sakai, Masashi Okuro and Seiji Nishino :
Brain resident mast cells affect sleep/wake physiology and pharmacology,
Sleep 2011: 25th Anniversary Meeting of the APSS, Minneapolis, USA, Jun. 2011.
25. Sachiko Chikahisa :
AMPK and PPAR contribute to sleep homeostasis,
Sleep 2011: 25th Anniversary Meeting of the APSS, Minneapolis, USA, Jun. 2011.
26. Noriyuki Shimizu, Sachiko Chikahisa, Kazuyoshi Kitaoka and Hiroyoshi Sei :
Sleep regulation in PPARalpha knockout mice,
Neuroscience 2010, San Diego, USA, Nov. 2010.
27. Sachiko Chikahisa, Kazuyoshi Kitaoka, Noriyuki Shimizu and Hiroyoshi Sei :
Hypothalamic AMPK contributes to homeostatic sleep regulation,
Neuroscience 2010, San Diego, USA, Nov. 2010.
28. Kazuyoshi Kitaoka, Shimizu Mika, Shimizu Noriyuki, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei :
Retinoic acid receptors antagonist LE540 atenuates EEG delta power during sleep via dopamine D1 receptor in mice,
Neuroscience 2010, San Diego, Nov. 2010.
29. Noriyuki Shimizu, Sachiko Chikahisa, Masahiro Oura and Hiroyoshi Sei :
Refeeding at light-onset after 24h fasting enhances EEG delta-power in NREM sleep in mice,
The 6th Congress of Asian Sleep Research SocietyThe 34th Annual Meeting of Japanese Society of Sleep Research, Osaka, Oct. 2009.
30. Hiroyoshi Sei, Sachiko Chikahisa and Noriyuki Shimizu :
Role of central AMPK in sleep homeostasis,
The 6th Congress of Asian Sleep Research SocietyThe 34th Annual Meeting of Japanese Society of Sleep Research, Osaka, Oct. 2009.
31. Kazuyoshi Kitaoka, Shimizu Mika, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei :
Four-week administration of retinoic acid receptors antagonist LE540 attenuates EEG delta power during sleep in mice,
The 6Th Congress of Asian Sleep Research Society, Oct. 2009.
32. Noriyuki Shimizu, Masahiro Oura, Sachiko Chikahisa and Hiroyoshi Sei :
EEG delta power in NREM sleep is enhanced by refeeding after 24-hr fasting in time-dependent manner,
36th International Union of Physiological Sciences, Kyoto, Aug. 2009.
33. Noriyuki Shimizu, Masahiro Oura, Sachiko Chikahisa and Hiroyoshi Sei :
EEG delta power in NREM sleep is enhanced by refeeding after 24-hr fasting in time-dependent manner,
36th International Union of Physiological Sciences, Kyoto, Aug. 2009.
34. Sachiko Chikahisa, Noriyuki Shimizu, Kazuyoshi Kitaoka, Nobuhiro Fujiki and Hiroyoshi Sei :
Central AMPK contributes to sleep regulation,
36th International Union of Physiological Sciences, Kyoto, Aug. 2009.
35. Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei :
Administration of Am80, an agonist of retinoic acid receptor, improves the aging-related decrease of REM sleep in SAMP8 mice,
36th International Congress of Physiological Sciences, Aug. 2009.
36. Hiroyoshi Sei, Sachiko Chikahisa, Kumiko Tominaga, Tomoko Kawai, Katsutaka Oishi, Norio Ishida and Kazuhito Rokutan :
Bezafibrate, a PPARs agonist, enhances EEG delta oscillation during NREM sleep in mice,
Neuroscience 2008, Washington DC, USA, Nov. 2008.
37. Sachiko Chikahisa, Kazuyoshi Kitaoka and Hiroyoshi Sei :
Complex auditory stimuli reduce anxiety level in an ovarian steroid hormone-dependent manner in female mice,
Neuroscience 2008, Washington DC, USA, Nov. 2008.
38. Hiroyoshi Sei, Sachiko Chikahisa, Kazuyoshi Kitaoka and Tomoko Kawai :
Relationship between spontaneous apnea and surge of arterial pressure during REM sleep in ICR mice,
Neuroscience 2007, San Diego, USA, Nov. 2007.
39. Sachiko Chikahisa, Kazuyoshi Kitaoka, Hiroyoshi Sei, Katsutaka Oishi, Shigenobu Shibata and Norio Ishida :
Chronic bezafibrate treatment advances circadian rhythms of sleep and body temperature in mice,
2nd World Congress of Chronobiology, Tokyo, Nov. 2007.
40. Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita :
Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults,
Neuroscience 2006, Atlanta, USA, Oct. 2006.
41. Sachiko Chikahisa, Hiroyoshi Sei, Atsuko Sano, Kazuyoshi Kitaoka and Yusuke Morita :
Anxiolytic effects of music depend on ovarian steroid in female mice,
International Behavioral Neuroscience Society, Whistler, Canada, May 2006.

国内講演発表:

1. 志内 哲也, 増田 拓也, 清水 紀之, 近久 幸子, 勢井 宏義 :
複雑な運動中の運動効率に及ぼすドーパミン作用,
第74回日本体力医学会, 2019年9月.
2. 志内 哲也, 清水 紀之, 大塚 愛理, 近久 幸子, 勢井 宏義 :
妊娠期における摂食リズムの違いが仔における行動に及ぼす影響,
第6回時間栄養科学研究会, 2019年8月.
3. Tetsuya Shiuchi, Keisuke Hashimoto, Ayaka Hashimoto, Airi Otsuka, Sachiko Chikahisa and Hiroyoshi Sei :
Dopaminergic neuron activation via gut PPAR-alpha enhanced the motivation for wheel running in mice,
NEURO2019, Jul. 2019.
4. 志内 哲也, 大塚 愛理, 近久 幸子, 勢井 宏義 :
ローヤルゼリー摂取による自発運動への影響,
第73回日本栄養食糧学会, 2019年5月.
5. 志内 哲也, 増田 拓也, 清水 紀之, 近久 幸子, 勢井 宏義 :
運動効率を高める中隔核でのドパミン作用,
第73回日本体力医学会, 2018年9月.
6. Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Airi Otsuka, Daisuke Tanioka and Hiroyoshi Sei :
Paternal psychological stress just before mating influences a formation of emotional behavior in next generation offspring mice,
The 41st Annual Meeting of the Japan Neuroscience Society, Jul. 2018.
7. Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka and Hiroyoshi Sei :
Social behavior is affected by mast cells activity in mice,
The 41st Annual Meeting of the Japan Neuroscience Society, Jul. 2018.
8. 増田 拓也, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei :
中隔核でのドパミン作用と運動効率の関係,
第41回日本神経科学学会大会, Jul. 2018.
9. 近久 幸子, 西野 精治, 勢井 宏義 :
慢性睡眠制限で生じる耐糖能異常の機序,
日本睡眠学会第43回定期学術集会, 2018年7月.
10. 谷岡 大輔, 大上 路生, 近久 幸子, 清水 紀之, 志内 哲也, 大塚 愛理, 勢井 宏義 :
性腺の摘出は睡眠を変化させる,
日本睡眠学会第43回定期学術集会, 2018年7月.
11. 清水 紀之, 志内 哲也, 近久 幸子, 大塚 愛理, 勢井 宏義 :
視床下部Agouti-related protein (AgRP)産生神経が絶食や再摂餌による睡眠調節に果たす役割,
日本睡眠学会第43回定期学術集会, 2018年7月.
12. Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Daisuke Tanioka, Airi Otsuka and Hiroyoshi Sei :
Paternal psychological stress causes an impairment of emotional behavior in offspring mice,
The 95th Annual Meeting of the Physiological Society of Japan, Mar. 2018.
13. Sachiko Chikahisa and Hiroyoshi Sei :
A mouse model of sleep disturbance and their phenotype,
95th Annual Meeting of the Physiological Society of Japan, Mar. 2018.
14. Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka and Hiroyoshi Sei :
The role of brain mast cells in mood and behavior,
The 95th Annual Meeting of the Physiological Society of Japan, Mar. 2018.
15. 清水 紀之, 近久 幸子, 志内 哲也, 谷岡 大輔, 大塚 愛理, 勢井 宏義 :
拘束ストレスを受けた雄マウスを父親とする次世代仔マウスは情動障害を有する,
第13回環境生理学プレコングレス, 2018年3月.
16. 大塚 愛理, 志内 哲也, 近久 幸子, 勢井 宏義 :
マウスにおける社会敗北性ストレスは血中FGF21を上昇させる,
第95回日本生理学会大会, 2018年3月.
17. 志内 哲也, 大塚 愛理, 近久 幸子, 勢井 宏義 :
夜食食モデルマウスはグルココルチコイド‐AgRPシステムにより骨格筋のインスリン抵抗性を発症する,
第32回日本糖尿病・肥満動物学会, 2018年2月.
18. 志内 哲也, 大塚 愛理, 近久 幸子, 清水 紀之, 勢井 宏義 :
グルココルチコイドにより視床下部AgRPが発現増強する臓器連関メカニズムの解明,
2017年度生命科学系学会合同年次大会(ConBio2017), 2017年12月.
19. 谷岡 大輔, 近久 幸子, 原田 紗希, 清水 紀之, 志内 哲也, 大塚 愛理, 勢井 宏義 :
慢性ストレスにおける睡眠・代謝異常と肥満細胞の関係,
第69回日本生理学会中国・四国地方会, 2017年10月.
20. 近久 幸子, 清水 紀之, 大塚 愛理, 志内 哲也, 勢井 宏義 :
睡眠不足モデルマウスにおける情動行動と運動学習能の変化,
日本睡眠学会第42回定期学術集会, 2017年6月.
21. 近久 幸子, 清水 紀之, 大塚 愛理, 志内 哲也, 西野 精治, 勢井 宏義 :
脳内肥満細胞の睡眠覚醒調節における役割,
第12回環境生理プレコングレス, 2017年3月.
22. Tetsuya Shiuchi, Noriyuki Shimizu, Airi Otsuka, Sachiko Chikahisa and Hiroyoshi Sei :
Alteration of behavior in offspring born from mother lived in the different feeding rhythm during pregnancy,
The 94th Annual Meeting of the Physiological Society of Japan, Mar. 2017.
23. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa and Hiroyoshi Sei :
Restricted high-fat diet is enough to improve social avoidance induced by social-defeat stress,
The 39th Annual Meeting of the Japan Neuroscience Society, Jul. 2016.
24. Noriyuki Shimizu, Yu Yoshioka, Takafumi Misaki, Yuki Kito, Sachiko Chikahisa, Tetsuya Shiuchi and Hiroyoshi Sei :
Sleep depth is affected by acute running exercise in mice.,
The 39th Annual Meeting of the Japan Neuroscience Society, Jul. 2016.
25. Tetsuya Shiuchi, Noriyuki Shimizu, Airi Otsuka, Sachiko Chikahisa and Hiroyoshi Sei :
Behavior alteration on offspring born from mother lived in the different feeding rhythm during pregnancy,
The 39th Annual Meeting of the Japan Neuroscience Society, Jul. 2016.
26. 近久 幸子, 清水 紀之, 志内 哲也, 西野 精治, 勢井 宏義 :
睡眠障害モデルマウスの糖代謝異常におけるマストセルの関与,
日本睡眠学会第41回定期学術集会, 2016年7月.
27. 清水 紀之, 吉岡 由布, 三崎 貴文, 木藤 有紀, 近久 幸子, 志内 哲也, 勢井 宏義 :
トレッドミルによる一過性の短時間運動に伴う睡眠への影響とケトン体代謝との関連性,
日本睡眠学会第41回定期学術集会, 2016年7月.
28. Noriyuki Shimizu, Yu Yoshioka, Takafumi Misaki, Sachiko Chikahisa, Tetsuya Shiuchi and Hiroyoshi Sei :
Acute running exercise enhances sleep in mice,
The 93rd Annual Meeting of the Physiological Society of Japan, Mar. 2016.
29. Yuki Kito, Keisuke Hashimoto, Ayaka Hashimoto, Sachiko Chikahisa, Hiroyoshi Sei and Tetsuya Shiuchi :
Exercise motivation is enhaced by peripheral PPAR-alpha stimulation,
93rd the Annual Meeting of the Physiological Society of Japan, Mar. 2016.
30. Airi Otsuka, Kanna Oura, Tetsuya Shiuchi, Sachiko Chikahisa and Hiroyoshi Sei :
Relationship between feeding rhythm and sleep pressure,
93rd Annual Meeting of the Physiological Society of Japan, Mar. 2016.
31. 近久 幸子, 勢井 宏義 :
ケトン体による睡眠ホメオスタシス調節機構,
日本睡眠学会第40回定期学術集会, 2015年7月.
32. 近久 幸子, 西野 精治, 勢井 宏義 :
睡眠覚醒調節における脳内マストセルの関与,
日本睡眠学会第40回定期学術集会, 2015年7月.
33. Sachiko Chikahisa and Hiroyoshi Sei :
The role of PPARs and ketone body metabolism in the regulation of sleep homeostasis,
92nd Annual Meeting of The Physiological Society of Japan, Mar. 2015.
34. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Junji Terao and Hiroyoshi Sei :
Physical exercise reduces social avoidance induced by defeated stress,
92nd Annual Meeting of The Physiological Society of Japan, Mar. 2015.
35. Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Junji Terao and Hiroyoshi Sei :
Effect of restricted high fat diet intake on behavior induced by social defeat stress,
The 37th Annual Meeting of the Japan Neuroscience Society, Sep. 2014.
36. 近久 幸子, 勢井 宏義 :
中枢ケトン体代謝による睡眠ホメオスタシス調節,
日本睡眠学会第39回定期学術集会, 2014年7月.
37. 近久 幸子, 児玉 亨, 征矢 敦至, 佐川 洋平, 石丸 雄二, 勢井 宏義, 西野 精治 :
脳内肥満細胞の睡眠覚醒調節における役割,
日本睡眠学会第39回定期学術集会, 2014年7月.
38. 四宮 圭, 西 結奈, 清水 紀之, 近久 幸子, 志内 哲也, 勢井 宏義 :
妊娠中の高脂肪食が仔マウスの脳機能に与える影響,
第65回日本生理学会中国四国地方会, 2013年11月.
39. 清水 紀之, 近久 幸子, 志内 哲也, 北岡 和義, 勢井 宏義 :
妊娠期母親マウスの摂餌制限が仔マウスの睡眠調節機構に与える影響,
第65回日本生理学会中国四国地方会, 2013年11月.
40. 志内 哲也, 大浦 寛奈, 清水 紀之, 近久 幸子, 勢井 宏義 :
異なる摂食スケジュールが睡眠に与える影響,
第34回日本肥満学会, 2013年10月.
41. 近久 幸子, 勢井 宏義 :
中枢脂質代謝と睡眠,
日本睡眠学会第38回定期学術集会, 2013年6月.
42. 近久 幸子, 清水 紀之, 志内 哲也, 藤原 広明, 勢井 宏義 :
脳内ケトン体代謝が睡眠ホメオスタシスへ及ぼす影響,
日本睡眠学会第38回定期学術集会, 2013年6月.
43. 志内 哲也, 近久 幸子, 大浦 寛奈, 二見 明香理, 藤原 広明, 勢井 宏義 :
摂食スケジュールの違いによる生体内エネルギー代謝循環の変動,
第56回日本糖尿病学会, 2013年5月.
44. Tetsuya Shiuchi, Akari Futami, Sachiko Chikahisa, Kanna Oura, Hiroaki Fujihara and Hiroyoshi Sei :
Effect of feeding rhythm on hypothalamic regulation of energy metabolism,
第90回日本生理学会, Mar. 2013.
45. 志内 哲也, 近久 幸子, 藤原 広明, 二見 明香理, 勢井 宏義 :
摂食リズムの乱れによるインスリン抵抗性発症と中枢性代謝調節機構との関連,
第33回日本肥満学会, 2012年10月.
46. 近久 幸子, 勢井 宏義 :
脳内脂質代謝と睡眠,
日本睡眠学会第37回定期学術集会, 2012年6月.
47. Tetsuya Shiuchi, Sachiko Chikahisa, Hiroaki Fujihara, Akari Futami and Hiroyoshi Sei :
Effect of differential feeding rhythm on insulin sensitivity and its mechanism,
日本生理学会, Mar. 2012.
48. Kazuyoshi Kitaoka, Shimizu Noriyuki, Sachiko Chikahisa, Nakagomi Madoka, Shudo Koichi, Hiroyoshi Sei and Kazuo Yoshizaki :
Chronic administration of retinoic acid receptor agonist Am80 induces the ADAM10 expression in the hippocampus of SAMP8 mice,
The 89th Annual Meeting of the Physiological Society of Japan, Mar. 2012.
49. 志内 哲也, 近久 幸子 :
生体リズムが中枢性代謝調節に与える影響と異所性脂肪蓄積の関連,
第2回 新学術領域研究・班会議, 2011年8月.
50. 北岡 和義, 大西 健, 清水 紀之, 近久 幸子, 小川 眞太朗, 吉﨑 和男, 勢井 宏義 :
HSF1はマウスの睡眠調節に関与する,
第5回臨床ストレス応答学会大会, 2010年11月.
51. 近久 幸子, 勢井 宏義 :
中枢脂質代謝と睡眠ホメオスタシス,
日本睡眠学会第35回定期学術集会, 2010年7月.

その他・研究会:

1. Dalanon Junhel, Sachiko Chikahisa, Noriyuki Shimizu, Waskitho Arief, Chavan Parimal, Lakshmi Swarna, Hiroyoshi Sei, Masamitsu Ohshima and Yoshizo Matsuka :
The effect of predictable chronic mild stress on sleep quality and nociception,
徳島大学脳科学クラスターミニリトリート, Feb. 2020.
2. 近久 幸子 :
脳内エネルギー代謝と睡眠の相互作用,
理化学研究所 健康``生き活き''羅針盤リサーチコンプレックス主催セミナー, 2018年11月.
3. 近久 幸子 :
脳内エネルギー代謝による睡眠制御,
理化学研究所 健康``生き活き''羅針盤リサーチコンプレックス主催セミナー, 2017年11月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 慢性不眠に起因する代謝異常発症の責任分子カスケードの同定と創薬基盤の構築 (研究課題/領域番号: 18K11047 )
  • 中枢ケトン体を介した新たな睡眠・高次脳機能調節機構 (研究課題/領域番号: 26380987 )
  • 睡眠・運動・代謝における相互的中枢-末梢連関 (研究課題/領域番号: 26282193 )
  • 睡眠・高次脳機能調節におけるアストロサイト脂質代謝の役割 (研究課題/領域番号: 23730706 )
  • 脳内脂質代謝の中枢作用とその機構 (研究課題/領域番号: 21730595 )
  • 夜型の生理機能:夜型モデルマウスを用いた解析的研究 (研究課題/領域番号: 18603005 )
  • 研究者番号(00452649)による検索