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Tokushima UniversityInstitute of Advanced Medical Sciences重点研究部門 (Files for researchmap) [PDF manual] [Auto-propagate to researchmap]

Research

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Field of Study

Molecular and Cellular Biology, Neurochemistry
Molecular and Cellular Biology, Neurochemistry
Molecular and Cellular Biology

Subject of Study

プリオン蛋白質による細胞死誘導機構
異常プリオン蛋白質の複製機構
高生産株の構築を目指した抗体生産CHO細胞の分子細胞生物学的研究

Book / Paper

Book:

1. S Sakaguchi and Keiji Uchiyama :
Prion Propagation, Its Neurotoxicity, and Protein Trafficking,
Caister Academic Press, Apr. 2019.
2. Keiji Uchiyama and S Sakaguchi :
A Molecular Mechanism for Abnormal Prion Protein Accumulation,
IntechOpen, Nov. 2018.
3. Keiji Uchiyama and Suehiro Sakaguchi :
Immunological strategies for the prevention and treatment of prion diseases.,
Caister Academic Press, Norfolk, UK, 2013.
4. Keiji Uchiyama, T Suzuki, H Tatsumi, H Kanetake and S Shioya :
Amplified 16S Ribosomal DNA Restriction Analysis of Microbial Community Structure During Fast Degradation of a Biopolymer, PHA, by Composting.,
Springer-Verlag, Berlin, 2002.
5. 清水 浩, Keiji Uchiyama, 永久 圭介 and 塩谷 捨明 :
生物工学実験書 第6章 環境化学実験, 6.2 河川の水質調査とモデル解析,
The Society for Biotechnology, Japan, 2002.

Academic Paper (Judged Full Paper):

1. Keiji Uchiyama, Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Morikazu Imamura, Tsuyoshi Mori, Hanae Takatsuki, Ryuichiro Atarashi and Suehiro Sakaguchi :
Ethanolamine Is a New Anti-Prion Compound,
International Journal of Molecular Sciences, Vol.22, No.21, 11742, 2021.
(Tokushima University Institutional Repository: 117551,   DOI: 10.3390/ijms222111742,   PubMed: 34769172,   Elsevier: Scopus)
2. Hideyuki Hara, Junji Chida, Keiji Uchiyama, Dini Agriani Pasiana, Etsuhisa Takahashi, Hiroshi Kido and Suehiro Sakaguchi :
Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells.,
Scientific Reports, Vol.11, No.1, 10109, 2021.
(Tokushima University Institutional Repository: 117718,   DOI: 10.1038/s41598-021-89586-6,   PubMed: 33980968)
3. Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu and Suehiro Sakaguchi :
Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire.,
International Journal of Molecular Sciences, Vol.22, No.6, 3268, 2021.
(Tokushima University Institutional Repository: 116339,   DOI: 10.3390/ijms22063268,   PubMed: 33806892,   Elsevier: Scopus)
4. Keiji Uchiyama, Miyata Hironori, Yamaguchi Yoshitaka, Imamura Morikazu, Okazaki Mariya, Pasiana Dini Agriani, Junji Chida, Hideyuki Hara, Atarashi Ryuichiro, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.,
International Journal of Molecular Sciences, Vol.21, No.19, 7260, 2020.
(Tokushima University Institutional Repository: 115634,   DOI: 10.3390/ijms21197260,   PubMed: 33019549,   Elsevier: Scopus)
5. Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.,
PLoS Pathogens, Vol.16, No.8, e1008823, 2020.
(Tokushima University Institutional Repository: 115613,   DOI: 10.1371/journal.ppat.1008823,   PubMed: 32845931)
6. Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh and Suehiro Sakaguchi :
The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region,
Molecular Neurobiology, Vol.57, 1203-1216, 2019.
(DOI: 10.1007/s12035-019-01804-5,   PubMed: 31707632,   Elsevier: Scopus)
7. Kohei Kaneyoshi, Noriko Yamano-Adachi, Yuichi Koga, Keiji Uchiyama and Takeshi Omasa :
Analysis of the immunoglobulin G (IgG) secretion efficiency in recombinant Chinese hamster ovary (CHO) cells by using Citrine-fusion IgG.,
Cytotechnology, Vol.71, No.1, 193-207, 2019.
(DOI: 10.1007/s10616-018-0276-7,   PubMed: 30610509,   Elsevier: Scopus)
8. Kohei Kaneyoshi, Kouki Kuroda, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano-Adachi, Yuichi Koga and Takeshi Omasa :
Secretion analysis of intracellular difficult-to-express immunoglobulin G (IgG) in Chinese hamster ovary (CHO) cells,
Cytotechnology, Vol.71, No.1, 305-316, 2019.
(DOI: 10.1007/s10616-018-0286-5,   PubMed: 30637508,   Elsevier: Scopus)
9. Kohei Kaneyoshi, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, Yuichi Koga and Takeshi Omasa :
Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production.,
Journal of Bioscience and Bioengineering, Vol.127, No.1, 107-113, 2019.
(DOI: 10.1016/j.jbiosc.2018.06.018,   PubMed: 30017708)
10. Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Rani Nandita Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with influenza A viruses.,
PLoS Pathogens, Vol.14, No.5, e1007049, 2018.
(Tokushima University Institutional Repository: 112206,   DOI: 10.1371/journal.ppat.1007049,   PubMed: 29723291)
11. Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel and Hermann C. Altmeppen :
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.,
Molecular Neurodegeneration, Vol.13, No.1, 18, 2018.
(Tokushima University Institutional Repository: 114545,   DOI: 10.1186/s13024-018-0248-6,   PubMed: 29625583,   Elsevier: Scopus)
12. Hideyuki Hara, Miyata Hironori, Das Rani Nandita, Junji Chida, Yoshimochi Tatenobu, Keiji Uchiyama, Watanabe Hitomi, Kondoh Gen, Yokoyama Takashi and Suehiro Sakaguchi :
Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.,
Journal of Virology, Vol.92, No.1, pii:e01368-17, 2018.
(Tokushima University Institutional Repository: 111465,   DOI: 10.1128/JVI.01368-17,   PubMed: 29046443,   CiNii: 1050845762396495104)
13. Suehiro Sakaguchi and Keiji Uchiyama :
Novel Amplification Mechanism of Prions through Disrupting Sortilin-Mediated Trafficking.,
Prion, Vol.11, No.6, 398-404, 2017.
(Tokushima University Institutional Repository: 112200,   DOI: 10.1080/19336896.2017.1391435,   PubMed: 29099278,   Elsevier: Scopus)
14. Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer and Suehiro Sakaguchi :
Prions amplify through degradation of the VPS10P sorting receptor sortilin.,
PLoS Pathogens, Vol.13, No.6, e1006470, 2017.
(Tokushima University Institutional Repository: 110433,   DOI: 10.1371/journal.ppat.1006470,   PubMed: 28665987)
15. Das Rani Nandita, Miyata Hironori, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.,
Archives of Virology, Vol.162, No.7, 1867-1876, 2017.
(Tokushima University Institutional Repository: 110119,   DOI: 10.1007/s00705-017-3295-3,   PubMed: 28255815,   Elsevier: Scopus)
16. Keiji Uchiyama, Miyata Hironori, Masashi Yano, Yoshitaka Yamaguti, Imamura Morikazu, Muramatsu Naomi, Das Rani Nandita, Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-terminal Residues 23-88 Restores Susceptibility to 22L Prions, But Not to RML Prions in PrP-Knockout Mice.,
PLoS ONE, Vol.9, No.10, e109737, 2014.
(DOI: 10.1371/journal.pone.0109737,   PubMed: 25330286)
17. Tomoyuki Yuasa, Kikuko Amo, Shuhei Ishikura, Hisao Nagaya, Keiji Uchiyama, Seiichi Hashida and Yousuke Ebina :
Development of in vitro model of insulin receptor cleavage induced by high glucose in HepG2 cells.,
Biochemical and Biophysical Research Communications, Vol.445, No.1, 236-243, 2014.
(DOI: 10.1016/j.bbrc.2014.01.187,   PubMed: 24508798,   Elsevier: Scopus)
18. Keiji Uchiyama, Miyata Hironori and Suehiro Sakaguchi :
Disturbed vesicular trafficking of membrane proteins in prion disease.,
Prion, Vol.7, No.6, 447-451, 2013.
(DOI: 10.4161/pri.27381,   PubMed: 24335150,   Elsevier: Scopus)
19. Keiji Uchiyama, Naomi Muramatsu, Masashi Yano, Takeshi Usui, Hironori Miyata and Suehiro Sakaguchi :
Prions disturb post-Golgi trafficking of membrane proteins.,
Nature Communications, Vol.4, 1846, 2013.
(DOI: 10.1038/ncomms2873,   PubMed: 23673631)
20. Yoshitaka Yamaguti, Hironori Miyata, Keiji Uchiyama, Akira Ootsuyama, Sachiko Inubushi, Tsuyoshi Mori, Naomi Muramatsu, Shigeru Katamine and Suehiro Sakaguchi :
Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions.,
PLoS ONE, Vol.7, No.8, e43540, 2012.
(DOI: 10.1371/journal.pone.0043540,   PubMed: 22927985)
21. G. Totsukawa, Y. Kaneko, Keiji Uchiyama, H. Toh, K. Tamura and H. Kondo :
VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion.,
The EMBO Journal, Vol.30, No.17, 3581-3593, 2011.
(DOI: 10.1038/emboj.2011.260,   PubMed: 21811234)
22. Tomoyuki Yuasa, Keiji Uchiyama, OGURA Yuko, Masafumi Kimura, TESHIGAWARA Kiyoshi, Toshio Hosaka, TANAKA Yoshinori, Toshiyuki Obata, SANO Hiroyuki, Kazuhiro Kishi and Yousuke Ebina :
The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and Gαq-Mediated Intracellular GLUT4 Vesicle Distribution,
Endocrine Journal, Vol.56, No.3, 345-359, 2009.
(DOI: 10.1507/endocrj.K08E-216,   PubMed: 19139597)
23. Keiji Uchiyama, G Totskawa, M Puhka, Y Kaneko, E Jokitalo, I Dreveny, F Beuron, X Zhang, P Freemont and H Kondo :
p37is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis.,
Developmental Cell, Vol.11, No.6, 803-816, 2006.
(DOI: 10.1016/j.devcel.2006.10.016,   PubMed: 17141156)
24. F Kano, H Kondo, A Yamamoto, Y Kaneko, Keiji Uchiyama, N Hosokawa, K Nagata and M Murata :
NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network.,
Genes to Cells, Vol.10, No.10, 989-999, 2005.
(DOI: 10.1111/j.1365-2443.2005.00894.x,   PubMed: 16164599)
25. X Yuan, P Simpson, C Mckeown, H Kondo, Keiji Uchiyama, R Wallis, I Dreveny, C Keetch, X Zhang, C Robinson, P Freemont and S Matthews :
Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97.,
The EMBO Journal, Vol.23, No.7, 1463-1473, 2004.
(DOI: 10.1038/sj.emboj.7600152,   PubMed: 15029246)
26. I Dreveny, H Kondo, Keiji Uchiyama, A Shaw, X Zhang and P Freemont :
Structural basis of the interaction between p97/VCP and its adaptor protein p47.,
The EMBO Journal, Vol.23, No.5, 1030-1039, 2004.
(DOI: 10.1038/sj.emboj.7600139,   PubMed: 14988733)
27. Keiji Uchiyama, Eija Jokitalo, Mervi Lindman, Mark Jackman, Fumi Kano, Masayuki Murata, Xiaodong Zhang and Hisao Kondo :
The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.,
The Journal of Cell Biology, Vol.161, No.6, 1067-1079, 2003.
(DOI: 10.1083/jcb.200303048,   PubMed: 12810701)
28. Keiji Uchiyama, E Jokitalo, F Kano, M Murata, X Zhang, B Canas, R Newman, C Rabouille, D Pappin, P Freemont and H Kondo :
VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo.,
The Journal of Cell Biology, Vol.159, No.5, 855-866, 2002.
(DOI: 10.1083/jcb.200208112,   PubMed: 12473691)
29. S Abd-Aziz, C D Ang, M H Yusof, A M I Karim, A Ariff, Keiji Uchiyama and S Shioya :
Effect of C/N ratio and starch concentration on ethanol production from sago starch using recombinant yeast.,
World Journal of Microbiology & Biotechnology, Vol.17, 713-719, 2001.
30. D Ang, S Abd-Aziz, M H Yusof, A M I Karim, A Ariff, Keiji Uchiyama and S Shioya :
Partial purification and characterization of amylolytic enzymes obtained from direct fermentation of Sago starch to ethanol by recombinant yeast,
Pakistan Journal of Biological Sciences, Vol.4, No.3, 266-270, 2001.
31. C Lostainkit, Keiji Uchiyama, S Ochi, T Takaoka, K Nagahisa and S Shioya :
Characterization of bacteriocin N15 produced by Enterococcus faecium N15 and cloning of the related genes.,
Journal of Bioscience and Bioengineering, Vol.91, No.4, 390-395, 2001.
(DOI: 10.1016/S1389-1723(01)80157-2,   PubMed: 16233010)
32. Keiji Uchiyama and S Shioya :
Modeling and optimization of alpha-amylase production in a recombinant yeast fed-batch culture taking account of the cell cycle population distribution.,
Journal of Biotechnology, Vol.71, 133-141, 1999.
33. H D Lee, Keiji Uchiyama, S Shioya and I Y Hwang :
Maximum glucoamylase production by a temperature-sensitive mutant of Saccharomyces cerevisiae in batch culture.,
Journal of Industrial Microbiology & Biotechnology, Vol.20, 160-165, 1998.
34. H Shimizu, K Yasuoka, Keiji Uchiyama and S Shioya :
Bioprocess fault detection by nonlinear multivariate analysis: application of an artificial autoassociative neural network and wavelet filter bank.,
Biotechnology Progress, Vol.14, No.1, 79-87, 1998.
35. H Shimizu, K Yasuoka, Keiji Uchiyama and S Shioya :
On-line fault diagnosis for an optimal rice -amylase production process of temperature-sensitive mutant of Saccharomyces cerevisiae by autoassociative neural network.,
Journal of Fermentation and Bioengineering, Vol.83, No.5, 435-442, 1997.
36. Keiji Uchiyama, M Morimoto, Y Yokoyama and S Shioya :
Cell cycle dependency of rice alpha-amylase production in a recombinant yeast.,
Biotechnology and Bioengineering, Vol.54, No.3, 262-271, 1997.
37. Keiji Uchiyama, T Ohotani, M Morimoto, S Shioya, K Suga, S Harashima and Y Oshima :
Optimization of rice alpha-amylase production using temperature-sensitive mutants of Saccharomyces cerevisiae for the PHO regulatory system.,
Biotechnology Progress, Vol.11, No.5, 510-517, 1995.

Review, Commentary:

1. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン病における神経変性のメカニズム,
Clinical Neuroscience, Vol.31, No.9, 1022-1024, Sep. 2013.
2. 近藤 久雄, Keiji Uchiyama and 十津川 剛 :
細胞内小器官の維持のための新たな分子機構,
Experimental Medicine, Vol.25, No.6, 848-851, Apr. 2007.
3. 近藤 久雄, Keiji Uchiyama and 十津川 剛 :
細胞内小器官の維持のための新たな分子機構,
Experimental Medicine, Vol.25, No.6, 848-851, Apr. 2007.
4. Keiji Uchiyama and H Kondo :
p97/p47-Mediated Biogenesis of Golgi and ER.,
The Journal of Biochemistry, Vol.137, No.2, 115-119, Feb. 2005.
(DOI: 10.1093/jb/mvi028,   PubMed: 15749824)
5. 近藤 久雄, Keiji Uchiyama and 沖米田 司 :
[p97-mediated membrane fusion is required for Golgi and ER assembly].,
Tanpakushitsu Kakusan Koso, Vol.49, No.7, 916-919, May 2004.
(PubMed: 15168492)
6. Keiji Uchiyama :
環境修復技術としてのコンポスト化,
Seibutsu-kogaku Kaishi, Vol.78, No.2, 67, 2000.
7. 塩谷 捨明, 清水 浩 and Keiji Uchiyama :
バクテリオシン産生乳酸菌の培養工学,
Seibutsu-kogaku Kaishi, Vol.77, No.11, 461-462, 1999.
8. Keiji Uchiyama and 塩谷 捨明 :
生分解性プラスチックのコンポスト化技術,
化学装置, Vol.40, 94-98, Jul. 1998.
9. 塩谷 捨明, 清水 浩 and Keiji Uchiyama :
乳酸菌によるバクテリオシンの培養工学,
Seibutsu-kogaku Kaishi, Vol.76, No.11, 460-461, 1998.

Proceeding of International Conference:

1. K Kaneyoshi, K Kuroda, N Yamano, Y Koga, Keiji Uchiyama and Takeshi Omasa :
Analysis of intracellular secretion processes by Citrine fusion IgG aiming to establish high producer CHO cells. Analysis of intracellular secretion processes by Citrine fusion IgG,
JAACT2018 Tsukuba, Tsukuba, Nov. 2018.
2. K Kaneyoshi, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, Y Koga and Takeshi Omasa :
Intracellular secretion analysis of recombinant therapeutic antibodies in engineered CHO cells aiming to establish high produce.,
The 25th Meeting of the European Society for Animal Cell Technology (ESACT2017), May 2017.
3. Kohei Kaneyoshi, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, Yuichi Koga and Takeshi Omasa :
Analysis of intracellular recombinant IgG secretion in engineered CHO cells,
The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2016 Kobe), Nov. 2016.
4. Keiji Uchiyama and Suehiro Sakaguchi :
Sorting of prion protein and PrPSc accumulation.,
International Prion Congress-Prion 2016, Tokyo, May 2016.
5. Keiji Uchiyama, Tomita Mitsuru and Suehiro Sakaguchi :
Mechanism of sortilin-mediated PrP degradation.,
Asian Pacific Prion Symposium 2015, Ishikawa Ongakudo, Kanazawa, Japan., Sep. 2015.
6. Tomita Mitsuru, Keiji Uchiyama, Usui Takeshi and Suehiro Sakaguchi :
Analysis of roles of N-terminal region of prion protein in the conversion into scrapie form by using prion-knockout cell.,
Asian Pacific Prion Symposium 2015, Ishikawa Ongakudo, Kanazawa, Japan, Sep. 2015.
7. Keiji Uchiyama and Suehiro Sakaguchi :
Post-Golgi trafficking of membrane proteins impaired by prion infection.,
Prion, Vol.8, 98, Trieste, Italy, Jun. 2014.
8. Keiji Uchiyama and Suehiro Sakaguchi :
Prions disturb post-Golgi membrane trafficking to the cell surface.,
Proceedings of The 9th International Symposium of the Institute Network, 30, Osaka, Jun. 2014.
9. Suehiro Sakaguchi and Keiji Uchiyama :
Prions impair post-Golgi trafficking of membrane proteins,
Asian Pacific Prion Symposium 2013, Nagasaki, Jul. 2013.
10. Keiji Uchiyama, G Totsukawa, M Rantanen, E Jokitalo and H Kondo :
p97-mediated biogenesis of the Golgi and ER.,
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, Jun. 2006.
11. Keiji Uchiyama, G Totsukawa and H Kondo :
p37, a novel adaptor of p97, is required for Golgi and ER maintenance during interphase.,
International Symposium on Life of Proteins, Hyogo, Oct. 2005.
12. Keiji Uchiyama, T Suzuki, H Tatsumi, H Kanetake and S Shioya :
Amplified 16S Ribosomal DNA Restriction Analysis of Microbial Community Structure During Fast Degradation of a Biopolymer, PHA, by Composting.,
Proceeding of the International Symposium on Microbiology of Composting, Innsbruck, Oct. 2000.
13. S Shioya, H Kodama, T Arimoto, Keiji Uchiyama and H Shimizu :
New Process Development for Mixed Culture Experiments,
Proceedings of the 5th Asia-Pacific Biochemical Engineering Conference, O-BP1, Nov. 1999.
14. Keiji Uchiyama, C Losteinkit, S Ochi and S Shioya :
Isolation and characterization of bacteriocin-producing Enterococcus faecium N15 from Japanese fermented food.,
Proceeding of Sixth Symposium on Lactic Acid Bacteria, C12, Veldhoven, Netherlands, Sep. 1999.
15. Keiji Uchiyama and S Shioya :
Modeling of rice -amylase production process in a recombinant yeast taking account of the cell cycle population.,
Proceeding of the 7th International Conference on Computer Application in Biotechnology, Osaka, May 1999.
16. Keiji Uchiyama, T Suzuki, H Tatsumi and S Shioya :
Microbial population analysis during composting process using ARDRA.,
Proceeding of 8th International Symposium on Microbial Ecology., Halifax, Canada, Sep. 1998.
17. H Shimizu, K Yasuoka, Keiji Uchiyama and S Shioya :
On-line Fault Detection for an Optimal Rice alpha-amylase Production Process of Saccharomyces cerevisiae by an Autoassociative Neural Network.,
Proceeding of Engineering Foundation, Chemical Engineering X, 4-6, May 1997.
18. S Shioya, Keiji Uchiyama, M Morimoto, K Suga, S Harashima and Y Oshima :
Cell cycle dependent rice alpha-amylase production by a recombinant yeast.,
the 9th NCRT; DOST-JSPS joint seminar on Biotechnology, Khon Kaen, Thailand, Oct. 1994.
19. S Shioya, Keiji Uchiyama, T Ohtani, A Kanda, K Suga, S Harashima and Y Oshima :
Maximum production in batch culture of S. cerevisiae using temperature-dependent gene expression system.,
Better living through innovative biochemical engineering, 708-710, 1994.
20. S Shioya, Keiji Uchiyama, T Ohtani, A Kanda, K Suga, S Harashima and Y Oshima :
Maximum production in batch culture of S. cerevisiae using temperature-dependent gene expression system.,
Proceeding of Seminar on Biochemical Engineering, 35-37, Taipei, Taiwan ROC, Dec. 1993.
21. S Shioya, Keiji Uchiyama, T Ohtani, A Kanda, K Suga, S Harashima and Y Oshima :
Maximum production in batch culture of S. cerevisiae using temperature-dependent gene expression system.,
Proceeding of 12th IFAC World Congress, Vol.8, 231-236, Sydney, Jul. 1993.
22. S Shioya, Keiji Uchiyama, T Ohtani, A Kanda, K Suga, S Harashima and Y Oshima :
Modeling and control for maximum production of S. cerevisiae using temperature-dependent gene expression system.,
Proceeding of 6th ECB, Vol.II, TU-390, Firenze, Jun. 1993.

Proceeding of Domestic Conference:

1. Keiji Uchiyama, Tetsuro Yoshimaru, Yosuke Matsushita, 尾野 雅哉, 三好 康雄, 笹 三徳 and Toyomasa Katagiri :
乳がん細胞における O型糖鎖修飾を介した IRE1の恒常的活性化機構,
第95回日本生化学会大会, Nov. 2022.
2. HAGIWARA Kosei, Keiji Uchiyama, Tetsuro Yoshimaru, Yosuke Matsushita, 三好 康雄, 笹 三徳 and Toyomasa Katagiri :
乳がん細胞におけるO 結合型糖鎖修飾GRP78/Bip の役割解明と創薬研究,
第81回日本癌学会学術総会, Oct. 2022.
3. Keiji Uchiyama, Tetsuro Yoshimaru, Yosuke Matsushita, 尾野 雅哉, 笹 三徳, 三好 康雄 and Toyomasa Katagiri :
乳がん細胞におけるO 結合型糖転移酵素の発現亢進はIRE1 の恒常的活性化を惹起する,
第81回日本癌学会学術総会, Sep. 2022.
4. HAGIWARA Kosei, Keiji Uchiyama, Tetsuro Yoshimaru, Yosuke Matsushita and Toyomasa Katagiri :
乳がん細胞におけるO結合型糖鎖修飾GRP78/Bipの役割解明と創薬研究,
第26回日本がん分子標的治療学会学術集会, Jun. 2022.
5. Keiji Uchiyama, Yosuke Matsushita, Tetsuro Yoshimaru, HAGIWARA Kosei and Toyomasa Katagiri :
乳がん細胞におけるO型糖鎖修飾IRE1経路の恒常的活性化を標的とした新規治療戦略の可能性,
第26回日本がん分子標的治療学会学術集会, Jun. 2022.
6. 兼吉 航平, 黒田 昂輝, 山野-足立 範子, 鬼塚 正義, 古賀 雄一, Keiji Uchiyama and Takeshi Omasa :
生産性向上を目指した医薬品抗体生産細胞における分泌過程解析,
日本化学工学会第84年会, G223, Mar. 2019.
7. Keiji Uchiyama and Suehiro Sakaguchi :
Identification and investigation of a novel anti-prion compound.,
第65回日本ウイルス学会学術集会, Oct. 2017.
8. Keiji Uchiyama, Tomohiro Tohkoh and Suehiro Sakaguchi :
High susceptibility of Sortilin-deficient cells to prion infection.,
第65回日本ウイルス学会学術集会, Oct. 2017.
9. 兼吉 航平, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, 古賀 雄一 and Takeshi Omasa :
高生産株の構築を目指した抗体生産CHO細胞内の分泌過程解,
第69回日本生物工学会大会, Sep. 2017.
10. Suehiro Sakaguchi and Keiji Uchiyama :
Prion propagation through sortilin degradation.,
第60回日本神経化学会大会, Sep. 2017.
11. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン病における異常プリオンの蓄積メカニズム,
第39回日本分子生物学会, 2P-0593, Dec. 2016.
12. Keiji Uchiyama :
Dysfunction of Sortilin by prion infection,
第64回日本ウイルス学会学術集会, P1-105, Oct. 2016.
13. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム,
第38回に本分子生物学会年会 第88回日本生化学会大会合同大会, Dec. 2015.
14. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.,
第63回日本ウイルス学会学術集会, Nov. 2015.
15. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
Novel molecular mechanism for accumulation of abnormal prion protein - Inhibition of Sortilin-mediated PrP degradation.,
第15回蛋白質科学会年会ワークショップ 「New development of prion biology」, Jun. 2015.
16. Suehiro Sakaguchi and Keiji Uchiyama :
プリオンによるポストゴルジ膜輸送障害,
第36回生体膜と薬物の相互作用シンポジウム「生体膜における蛋白質の機能制御システムと疾患」, Nov. 2014.
17. 富田 満, Keiji Uchiyama, 臼井 健 and Suehiro Sakaguchi :
プリオンノックアウト細胞を用いたプリオンタンパク質N末端領域の異常プリオン形成における役割の解明,
第62回日本ウイルス学会学術集会, Nov. 2014.
18. Keiji Uchiyama, 富田 満, 臼井 健 and Suehiro Sakaguchi :
新規プリオン結合因子Sortilinのプリオン感染における役割,
第62回日本ウイルス学会学術集会, Nov. 2014.
19. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染と小胞輸送障害,
第87回日本生化学会 シンポジウム 認知症克服に向けて:プリオン病をもっと知る., Oct. 2014.
20. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす,
第29回中国四国ウイルス研究会プログラム・抄録集, 26, Jun. 2014.
21. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染によるポストゴルジ小胞輸送障害,
第66回日本細胞生物学会要旨集, 149, Jun. 2014.
22. Keiji Uchiyama :
神経変性疾患と小胞輸送-プリオン病における小胞輸送障害,
尚醸会バイオテクノロジーセミナー, Nov. 2013.
23. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染はポストゴルジ小胞輸送を抑制する,
第61回日本ウイルス学会学術集会, Nov. 2013.
24. Keiji Uchiyama and Suehiro Sakaguchi :
Prions impair post-Golgi trafficking of membrane proteins,
日本生化学会, Sep. 2013.
25. Shizuka Matsumura, Shota Ikawa, Masayoshi Onitsuka, Akihiro Shirai, Hideaki Maseda, Keiji Uchiyama and Takeshi Omasa :
CHO細胞における小胞出芽関連因子Arfのクローニングと発現抑制によるタンパク質生産への影響,
日本動物細胞工学会2013年度大会(JAACT2013), 69, Jul. 2013.
26. Suehiro Sakaguchi and Keiji Uchiyama :
Inhibition of Post-Golgi Membrane Traffic in Prion-Infected Cells,
第35回分子生物学会年会(ポスター発表), Dec. 2012.
27. Suehiro Sakaguchi and Keiji Uchiyama :
Inhibition of Post-Golgi Membrane Traffic in Prion-Infected Cells,
第35回分子生物学会年会 ワークショップ「Membrane Traccic and Diseases」(口頭発表), Dec. 2012.
28. 十津川 剛, Keiji Uchiyama, 金子 弥生, 小川 洋子 and 近藤 久雄 :
p97-ATPase-mediated membrane fusion.,
第28回日本分子生物学会年会 ワークショップ 「細胞機能のキープレーヤーAAA+タンパク質の世界」, Dec. 2005.
29. Keiji Uchiyama and 近藤 久雄 :
p97-mediated membrane fusion.,
第27回日本分子生物学会年会, ワークショップ「AAA+タンパク質の細胞機能と構造」, Dec. 2004.
30. Keiji Uchiyama, 加納 ふみ, E Jokitlo, X Zhaug, 村田 昌之, R Newman, D Pappin, 塩谷 捨明, P Freemont and 近藤 久雄 :
The p97/p47 pathway in Golgi reassembly.,
第24回日本分子生物学会年会, シンポジウム「細胞内メンブレントラフィックーOrganellar Identity and Dynamics―」, Dec. 2001.
31. Keiji Uchiyama, M Morimoto, S Shioya, K Suga, S Harashima and Y Oshima :
Rice alpha-amylase production by a recombinant yeast.,
第27回シンポジウムシリーズ, 110-115, 1994.

Et cetera, Workshop:

1. Keiji Uchiyama :
プリオン病-異常プリオン蓄積メカニズムの解明,
「核・ミトコンドリア遺伝子の網羅的トランスゲノム解析による心不全重症化機構の解明」研究班シンポジウム 「蛋白質の構造と病態」, Feb. 2016.
2. Keiji Uchiyama, 臼井 健, Masashi Yano and Suehiro Sakaguchi :
プリオン感染はポストゴルジ小胞輸送を抑制する,
第28回中国四国ウイルス研究会, Jun. 2013.
3. Keiji Uchiyama, 臼井 健, Masashi Yano and Suehiro Sakaguchi :
プリオン感染によるポストゴルジ小胞輸送抑制,
第54回日本生化学会 中国・四国支部例会, Jun. 2013.
4. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染は神経細胞におけるインスリンシグナル異常を引き起こす,
第27回中国四国ウイルス研究会抄録集, Jun. 2012.
5. Keiji Uchiyama and Yousuke Ebina :
Functional roles of TUG and p97/VCP in Glut4 trafficking.,
第34回分子生物学会年会, 4T14a-3, Dec. 2011.
6. Keiji Uchiyama and Yousuke Ebina :
Functional roles of TUG and p97/VCP in Glut4 trafficking.,
第34回分子生物学会年会, 3P-0673, Dec. 2011.
7. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染細胞における細胞内小胞輸送の抑制,
第26回中国四国ウイルス研究会抄録集, Jun. 2011.
8. Suehiro Sakaguchi, 宮田 博規, Yoshitaka Yamaguti, 村松 直美, Tsuyoshi Mori, Keiji Uchiyama and Sachiko Inubushi :
異なるプリオン株の産生メカニズムについて,
第26回中国四国ウイルス研究会 徳島大学青藍会館 徳島, Jun. 2011.
9. Keiji Uchiyama and Yousuke Ebina :
Role of BIG2, a Guanine-Nucleotide Exchanging Factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter Translocation,
第32回 日本分子生物学会年会, 168, Dec. 2009.

Patent:

1. 塩谷 捨明, 清水 浩 and Keiji Uchiyama : 分離型混合培養装置, 981505, .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • がん微小環境でのIRE1恒常的活性化に必須な小胞体-ゴルジ体間シャトル輸送機構の解明 (Project/Area Number: 23K06651 )
  • Development of innovative therapies based on drug-resistance mechanism originating from the BIG3-PHB2 complexes (Project/Area Number: 23H02970 )
  • Membrane trafficking involved in the degradation of aged brain protein (Project/Area Number: 17H05702 )
  • Elucidation of the mechanism of Sortilin reduction by prion infection and its application to therapeutic method development (Project/Area Number: 17K08859 )
  • Development of basic technology for therapy of prion diseases based on Sortilin function (Project/Area Number: 26460557 )
  • Role of BIG2, a Guanine-Nucleotide Exchanging factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter Translocation (Project/Area Number: 21570142 )
  • Molecular mechanisms of Insulin signal transduction and diabetes mellitus (Project/Area Number: 20390095 )
  • ldentification and function analysis of a SNARE complex for p97/p37-mediated membrane fusion pathway (Project/Area Number: 19570195 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 18390104 )
  • 新規の細胞内膜融合機構p97/p37経路の解明 (Project/Area Number: 18050046 )
  • p97を介したゴルジ体再構成過程におけるVCIP135による脱ユビキチン化の役割 (Project/Area Number: 17770180 )
  • 小胞体の網状構造の形成機構 (Project/Area Number: 17028060 )
  • Development of a novel controller for antimicrobial nisin production, using interaction of microorganisms (Project/Area Number: 10650784 )
  • Isolation of a novel bacteriocin-producing lactic acid bacteria and its use in food preservation (Project/Area Number: 10450311 )
  • Development of an on-line fault diagnosis and operation system for an optimal rice-alphaamylase production process of temperature-sensitive mutant of Saccharomyces cerevisiae by autoassociative neural network (Project/Area Number: 08455381 )
  • Search by Researcher Number (60294039)