type: misc

label: url

en: 「口腔感染症および非感染性疾患予防を目指した粘膜ワクチンの開発」-新たな経鼻ダブルDNAアジュバントシステムによる健康長寿社会への貢献-

en: 日本口腔衛生学会雑誌

ja: 日本口腔衛生学会雑誌


en: Development of Mucosal Vaccines as Novel Preventive Methods against Infectious and Noncommunicable Diseases (NCDs): Contribution to a Society of Health and Longevity

en: The surface layer of the mucosa, which in adult humans, is estimated to have a surface area over 200 times greater than that of the skin, is constantly in contact with foreign antigens, against which non-specific defense (innate immune mechanisms) and specific defense (acquired immune mechanisms) are activated. In the mucosal areas that are the entry points for foreign antigens, the efficient production and secretion of secretory IgA (SIgA) antibodies, which are the main form of specific defense, and mucosal vaccines, which are an efficient antigen delivery system for inducing and promoting antibody production, may offer a strategic tool for preventing not only infections, but also the development of lifestyle-related diseases. We have previously undertaken research and development of an immunostimulating agent (adjuvant) for use with mucosal vaccines based on mucosal immunity, particularly nasal vaccines that are administered to the nasal cavity. More specifically, a double DNA adjuvant (dDA) system that targets dendritic cells, which are one of antigen-presenting cells, was developed, and basic research was conducted using a number of different antigens, including a comparison of the immune response to these antigens when they were introduced into the nasal cavities of young and old experimental animals (mice). Of late, we have been working toward the development of a mucosal vaccine capable of preventing infection or lifestyle-related disease that can also be used in older people. In this review article, I will introduce the advantages of mucosal vaccines as well as recent findings in our group.

en: Journal of Oral Health and Biosciences

ja: Journal of Oral Health and Biosciences


en: ダブルDNAアジュバントシステムによる唾液分泌型IgA抗体誘導と抗免疫老化

ja: ダブルDNAアジュバントシステムによる唾液分泌型IgA抗体誘導と抗免疫老化

en: 神奈川歯学

ja: 神奈川歯学


en: アルカリ性の飲み物を頻回に飲めば，う蝕のリスクは高まらない?

ja: アルカリ性の飲み物を頻回に飲めば，う蝕のリスクは高まらない?

en: 歯科衛生士

ja: 歯科衛生士


en: Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae.

en: To develop safe vaccines for inducing mucosal immunity to major pulmonary bacterial infections, appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants must be considered. Such vaccine constructs can induce Ag-specific immune responses that protect against mucosal infections. In particular, it has been shown that simply mixing the adjuvant with the bacterial Ag is a relatively easy means of constructing adjuvant-based mucosal vaccine preparations; the resulting vaccines can elicit protective immunity. DNA-based nasal adjuvants targeting mucosal DCs have been studied in order to induce Ag-specific mucosal and systemic immune responses that provide essential protection against microbial pathogens that invade mucosal surfaces. In this review, initially a plasmid encoding the cDNA of Flt3 ligand (pFL), a molecule that is a growth factor for DCs, as an effective adjuvant for mucosal immunity to pneumococcal infections, is introduced. Next, the potential of adding unmethylated CpG oligodeoxynucleotide and pFL together with a pneumococcal Ag to induce protection from pneumococcal infections is discussed. Pneumococcal surface protein A has been used as vaccine for restoring mucosal immunity in older persons. Further, our nasal pFL adjuvant system with phosphorylcholine-keyhole limpet hemocyanin (PC-KLH) has also been used in pneumococcal vaccine development to induce complete protection from nasal carriage by Streptococcus pneumoniae. Finally, the possibility that anti-PC antibodies induced by nasal delivery of pFL plus PC-KLH may play a protective role in prevention of atherogenesis and thus block subsequent development of cardiovascular disease is discussed.

en: Microbiology and Immunology

ja: Microbiology and Immunology


en: 樹状細胞を活性化する経鼻アジュバントの開発-感染症・NCD制御を目指す粘膜ワクチン-

en: Journal of Dental Health

ja: 口腔衛生学会雑誌


en: インフルエンザ感染症における粘膜免疫とその制御による治療効果の増強

ja: インフルエンザ感染症における粘膜免疫とその制御による治療効果の増強

en: 新薬と臨床

ja: 新薬と臨床


en: 気道の生体防御能，粘膜免疫を増強するマクロライド系薬とインフルエンザ感染

ja: 気道の生体防御能，粘膜免疫を増強するマクロライド系薬とインフルエンザ感染

en: Medicine and Drug Journal

ja: 医薬ジャーナル


en: 第2章「歯周病と喫煙との関連性についてのEBM」

ja: 第2章「歯周病と喫煙との関連性についてのEBM」