type: misc

label: url

en: 【自己免疫性肝疾患-自己免疫性肝炎，原発性胆汁性胆管炎，原発性硬化性胆管炎-】発症機序，病理 自己免疫性肝炎 自己免疫性肝炎の病理(解説/特集)

en: Nihon Rinsho. Japanese Journal of Clinical Medicine

ja: 日本臨牀


en: 肝臓病理所見のとり方とその解釈

ja: 肝臓病理所見のとり方とその解釈

en: 法医病理

ja: 法医病理


en: Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis.

en: Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism. Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low groups. Clinicopathological factors including miR-223 expression were compared between the high (n = 32) and low Fbxw7 groups (n = 24). Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3 years disease-free survival of the low and high Fbxw7 groups were 12.5% and 47.0%, respectively (P = 0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factors for recurrence of CRLM (hazard ratio: 2.390, P = 0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (P = 0.017). Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR-223 might be a possible regulator of Fbxw7.

en: Journal of Hepato-Biliary-Pancreatic Sciences


en: [画像診断と病理] 胎盤分葉状解離性平滑筋腫

ja: [画像診断と病理] 胎盤分葉状解離性平滑筋腫

en: 画像診断

ja: 画像診断


en: [画像診断と病理] 尿膜管癌(粘液性腺癌)

ja: [画像診断と病理] 尿膜管癌(粘液性腺癌)


en: Relationship between NGF produced by bronchial epithelial cells and airway hyperresponsiveness in bronchial asthma

ja: NGFと気道過敏性

en: Clinical Immunology & Allergology

ja: 臨床免疫·アレルギー科