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Tokushima University > Institute of Advanced Medical Sciences > Institute for Genome Research >
Tokushima University > Research Clusters > Research Clusters (Prioritized) > 1702005 難病の克服を目指した免疫学研究の拠点形成 >
Tokushima University > Graduate School of Medical Sciences > Medical Science > Course of Preventive Medicine >
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Research Activity

Field of Study

Immunology, Molecular Biology

Subject of Study

Genetic analysis of autoimmune diseases, Immunotherapy of cancer

Book / Paper

Academic Paper (Judged Full Paper):

1.Hikari Okamura, Il-mi Okazaki, Kenji Shimizu, Takumi Maruhashi, Daisuke Sugiura, Reina Mizuno and Taku Okazaki :
PD-1 aborts the activation trajectory of autoreactive CD8 T cells to prohibit their acquisition of effector functions.,
Journal of Autoimmunity, 102296, 2019.
(Tokushima University Institutional Repository: 113693,   DOI: 10.1016/j.jaut.2019.06.007,   PubMed: 31277964)
2.Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki, Kenji Shimizu, Takeo K. Maeda, Tatsuya Takemoto and Taku Okazaki :
Restriction of PD-1 function by -PD-L1/CD80 interactions is required for optimal T cell responses.,
Science, Vol.364, No.6440, 558-566, 2019.
(DOI: 10.1126/science.aav7062,   PubMed: 31000591)
3.Reina Mizuno, Daisuke Sugiura, Kenji Shimizu, Takumi Maruhashi, Mizuki Watada, Il-mi Okazaki and Taku Okazaki :
PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.,
Frontiers in Immunology, Vol.10, 630, 2019.
(DOI: 10.3389/fimmu.2019.00630,   PubMed: 31001256)
4.Reina Mizuno, Takumi Maruhashi, Daisuke Sugiura, Kenji Shimizu, Mizuki Watada, Il-mi Okazaki and Taku Okazaki :
PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.,
Biochemical and Biophysical Research Communications, Vol.511, No.3, 491-497, 2019.
(DOI: 10.1016/j.bbrc.2019.02.004,   PubMed: 30771904)
5.Takeo K. Maeda, Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi and Taku Okazaki :
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.,
The Journal of Biological Chemistry, Vol.294, No.15, 6017-6026, 2019.
(Tokushima University Institutional Repository: 113688,   DOI: 10.1074/jbc.RA119.007455,   PubMed: 30760527)
6.Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura, Suzuka Takahashi, Takeo K. Maeda, Kenji Shimizu and Taku Okazaki :
LAG-3 inhibits the activation of CD4 T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.,
Nature Immunology, Vol.19, No.12, 1415-1426, 2018.
(DOI: 10.1038/s41590-018-0217-9,   PubMed: 30349037)
7.Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Minoru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hisanori Uehara, Keisuke Izumi, Koichi Tsuneyama, Il-mi Okazaki, Taku Okazaki, Kazuyoshi Hosomichi, Ayako Shiraki, Makoto Shibutani, Kunitoshi Mitsumori and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).,
Journal of Autoimmunity, Vol.86, 75-92, 2018.
(Tokushima University Institutional Repository: 112347,   DOI: 10.1016/j.jaut.2017.09.006,   PubMed: 28931462)
8.Yoshihiro Hayakawa, Manabu Kawada, Hiroyoshi Nishikawa, Takahiro Ochiya, Hideyuki Saya, Hiroyuki Seimiya, Ryoji Yao, Masahiro Hayashi, Chieko Kai, Akira Matsuda, Tomoki Naoe, Atsushi Ohtsu, Taku Okazaki, Hideo Saji, Masataka Sata, Haruhiko Sugimura, Yuichi Sugiyama, Masakazu Toi and Tatsuro Irimura :
Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.,
Cancer Science, Vol.107, No.2, 189-202, 2016.
(Tokushima University Institutional Repository: 112369,   DOI: 10.1111/cas.12857,   PubMed: 26919617)
9.Taku Okazaki, Shunsuke Chikuma, Yoshiko Iwai, Sidonia Fagarasan and Tasuku Honjo :
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.,
Nature Immunology, Vol.14, No.12, 1212-1218, 2013.
(DOI: 10.1038/ni.2762,   PubMed: 24240160)
10.Satoru Iwamoto, Masahiro Kido, Nobuhiro Aoki, Hisayo Nishiura, Ryutaro Maruoka, Aki Ikeda, Taku Okazaki, Tsutomu Chiba and Norihiko Watanabe :
TNF- is essential in the induction of fatal autoimmune hepatitis in mice through upregulation of hepatic CCL20 expression.,
Clinical Immunology, Vol.146, No.1, 15-25, 2013.
(DOI: 10.1016/j.clim.2012.10.008,   PubMed: 23178752)
11.Yoshio Sugino, Nobuyuki Nishikawa, Koji Yoshimura, Sadako Kuno, Yukio Hayashi, Naoki Yoshimura, Taku Okazaki, Akihiro Kanematsu and Osamu Ogawa :
BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis.,
Scientific Reports, Vol.2, 317, 2012.
(DOI: 10.1038/srep00317,   PubMed: 22432050)
12.Hisako Kayama, Yoshiyasu Ueda, Yukihisa Sawa, Seong Gyu Jeon, Ji Su Ma, Ryu Okumura, Atsuko Kubo, Masaru Ishii, Taku Okazaki, Masaaki Murakami, Masahiro Yamamoto, Hideo Yagita and Kiyoshi Takeda :
Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.109, No.13, 5010-5015, 2012.
(DOI: 10.1073/pnas.1114931109,   PubMed: 22403066)
13.Satoru Iwamoto, Masahiro Kido, Nobuhiro Aoki, Hisayo Nishiura, Ryutaro Maruoka, Aki Ikeda, Taku Okazaki, Tsutomu Chiba and Norihiko Watanabe :
IFN- is reciprocally involved in the concurrent development of organ-specific autoimmunity in the liver and stomach.,
Autoimmunity, Vol.45, No.2, 186-198, 2011.
(DOI: 10.3109/08916934.2011.616559,   PubMed: 21995497)
14.Taku Okazaki, Il-mi Okazaki, Jian Wang, Daisuke Sugiura, Fumio Nakaki, Taku Yoshida, Yu Kato, Sidonia Fagarasan, Masamichi Muramatsu, Tomoo Eto, Kyoji Hioki and Tasuku Honjo :
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice,
The Journal of Experimental Medicine, Vol.208, No.2, 395-407, 2011.
(DOI: 10.1084/jem.20100466,   PubMed: 21300912)
15.Seigo Terawaki, Shunsuke Chikuma, Shiro Shibayama, Tamon Hayashi, Takao Yoshida, Taku Okazaki and Tasuku Honjo :
IFN- directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.,
The Journal of Immunology, Vol.186, No.5, 2772-2779, 2011.
(DOI: 10.4049/jimmunol.1003208,   PubMed: 21263073)
16.Nobuhiro Aoki, Masahiro Kido, Satoru Iwamoto, Hisayo Nishiura, Ryutaro Maruoka, Junya Tanaka, Takeshi Watanabe, Yoshimasa Tanaka, Taku Okazaki, Tsutomu Chiba and Norihiko Watanabe :
Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.,
Gastroenterology, Vol.140, No.4, 1322-1333.e15, 2011.
(DOI: 10.1053/j.gastro.2011.01.002,   PubMed: 21237169)
17.Hyun-Tak Jin, Rafi Ahmed and Taku Okazaki :
Role of PD-1 in regulating T-cell immunity.,
Current Topics in Microbiology and Immunology, Vol.350, 17-37, 2011.
(DOI: 10.1007/82_2010_116,   PubMed: 21061197)
18.Shunsuke Sakai, Ikuo Kawamura, Taku Okazaki, Kohsuke Tsuchiya, Ryousuke Uchiyama and Masao Mitsuyama :
PD-1-PD-L1 pathway impairs T(h)1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guérin.,
International Immunology, Vol.22, No.12, 915-925, 2010.
(DOI: 10.1093/intimm/dxq446,   PubMed: 21047981)
19.Jian Wang, Il-mi Okazaki, Taku Yoshida, Shunsuke Chikuma, Yu Kato, Fumio Nakaki, Hiroshi Hiai, Tasuku Honjo and Taku Okazaki :
PD-1 deficiency results in the development of fatal myocarditis in MRL mice.,
International Immunology, Vol.22, No.6, 443-452, 2010.
(DOI: 10.1093/intimm/dxq026,   PubMed: 20410257)
20.Ryosuke Hino, Kenji Kabashima, Yu Kato, Hiroaki Yagi, Motonobu Nakamura, Tasuku Honjo, Taku Okazaki and Yoshiki Tokura :
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma.,
Cancer, Vol.116, No.7, 1757-1766, 2010.
(DOI: 10.1002/cncr.24899,   PubMed: 20143437)
21.Shimpei Kasagi, Seiji Kawano, Taku Okazaki, Tasuku Honjo, Akio Morinobu, Saori Hatachi, Kenichiro Shimatani, Yoshimasa Tanaka, Nagahiro Minato and Shunichi Kumagai :
Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.,
The Journal of Immunology, Vol.184, No.5, 2337-2347, 2010.
(DOI: 10.4049/jimmunol.0901652,   PubMed: 20139271)
22.Shunsuke Chikuma, Seigo Terawaki, Tamon Hayashi, Ryusuke Nabeshima, Takao Yoshida, Shiro Shibayama, Taku Okazaki and Tasuku Honjo :
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.,
The Journal of Immunology, Vol.182, No.11, 6682-6689, 2009.
(DOI: 10.4049/jimmunol.0900080,   PubMed: 19454662)
23.Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Hiroyuki Aburatani, Taku Okazaki, Tasuku Honjo, Masaru Takeuchi and Manabu mochizuki :
T cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions.,
Investigative Ophthalmology & Visual Science, Vol.50, No.6, 2862-2870, 2009.
(DOI: 10.1167/iovs.08-2846,   PubMed: 19182257)
24.Fang Jiang, Taku Yoshida, Fumio Nakaki, Seigo Terawaki, Shunsuke Chikuma, Yu Kato, Il-mi Okazaki, Tasuku Honjo and Taku Okazaki :
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.,
International Immunology, Vol.21, No.5, 499-509, 2009.
(DOI: 10.1093/intimm/dxp020,   PubMed: 19261693)
25.Masahiro Kido, Norihiko Watanabe, Taku Okazaki, Takuji Akamatsu, Junya Tanaka, Kazuyuki Saga, Akiyoshi Nishio, Tasuku Honjo and Tsutomu Chiba :
Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling,
Gastroenterology, Vol.135, No.4, 1333-1343, 2008.
(DOI: 10.1053/j.gastro.2008.06.042,   PubMed: 18651994)
26.Taku Yoshida, Fang Jiang, Tasuku Honjo and Taku Okazaki :
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.105, No.9, 3533-3538, 2008.
(DOI: 10.1073/pnas.0710951105,   PubMed: 18299579)
27.Kathy A. Green, Taku Okazaki, Tasuku Honjo, W. James Cook and William R. Green :
The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome.,
Journal of Virology, Vol.82, No.5, 2456-2469, 2008.
(DOI: 10.1128/JVI.01665-07,   PubMed: 18094175)
28.David Yin-wei Lin, Yoshimasa Tanaka, Masashi Iwasaki, Apostolos G. Gittis, Hua-Poo Su, Bunzo Mikami, Taku Okazaki, Tasuku Honjo, Nagahiro Minato and David N. Garboczi :
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.105, No.8, 3011-3016, 2008.
(DOI: 10.1073/pnas.0712278105,   PubMed: 18287011)
29.Seigo Terawaki, Yoshimasa Tanaka, Tomokazu Nagakura, Tamon Hayashi, Shiro Shibayama, Kaori Muroi, Taku Okazaki, Bunzo Mikami, David N. Garboczi, Tasuku Honjo and Nagahiro Minato :
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.,
International Immunology, Vol.19, No.7, 881-890, 2007.
(DOI: 10.1093/intimm/dxm059,   PubMed: 17606978)
30.Taku Okazaki and Tasuku Honjo :
PD-1 and PD-1 ligands: from discovery to clinical application.,
International Immunology, Vol.19, No.7, 813-824, 2007.
(DOI: 10.1093/intimm/dxm057,   PubMed: 17606980)
31.Junzo Hamanishi, Masaki Mandai, Masashi Iwasaki, Taku Okazaki, Yoshimasa Tanaka, Ken Yamaguchi, Toshiro Higuchi, Haruhiko Yagi, Kenji Takakura, Nagahiro Minato, Tasuku Honjo and Shingo Fujii :
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.104, No.9, 3360-3365, 2007.
(DOI: 10.1073/pnas.0611533104,   PubMed: 17360651)
32.Taku Okazaki and Tasuku Honjo :
The PD-1-PD-L pathway in immunological tolerance.,
Trends in Immunology, Vol.27, No.4, 195-201, 2006.
(DOI: 10.1016/j.it.2006.02.001,   PubMed: 16500147)
33.Taku Okazaki and Tasuku Honjo :
Rejuvenating exhausted T cells during chronic viral infection.,
Cell, Vol.124, No.3, 459-461, 2006.
(DOI: 10.1016/j.cell.2006.01.022,   PubMed: 16469690)
34.Taku Okazaki, Yumi Otaka, Jiang Wang, Hiroshi Hiai, Toshiyuki Takai, Jeffrey V. Ravetch and Tasuku Honjo :
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.,
The Journal of Experimental Medicine, Vol.202, No.12, 1643-1648, 2005.
(DOI: 10.1084/jem.20051984,   PubMed: 16352741)
35.Taku Okazaki and Jiang Wang :
PD-1/PD-L pathway and autoimmunity.,
Autoimmunity, Vol.38, No.5, 353-357, 2005.
(DOI: 10.1080/08916930500124072,   PubMed: 16227150)
36.Masaya Kobayashi, Seiji Kawano, Saori Hatachi, Chiyo Kurimoto, Taku Okazaki, Yoshiko Iwai, Tasuku Honjo, Yoshimasa Tanaka, Nagahiro Minato, Takahide Komori, Sakan Maeda and Shunichi Kumagai :
Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome.,
The Journal of Rheumatology, Vol.32, No.11, 2156-2163, 2005.
(PubMed: 16265694)
37.Jiang Wang, Taku Yoshida, Fumio Nakaki, Hiroshi Hiai, Taku Okazaki and Tasuku Honjo :
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.102, No.33, 11823-11828, 2005.
(DOI: 10.1073/pnas.0505497102,   PubMed: 16087865)
38.Taku Okazaki and Tasuku Honjo :
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.,
Trends in Molecular Medicine, Vol.11, No.7, 322-326, 2005.
(DOI: 10.1016/j.molmed.2005.05.001,   PubMed: 15935731)
39.Hans Christian Probst, Kathy McCoy, Taku Okazaki, Tasuku Honjo and Maries van den Broek :
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.,
Nature Immunology, Vol.6, No.3, 280-286, 2005.
(DOI: 10.1038/ni1165,   PubMed: 15685176)
40.Taku Okazaki, Yoshimasa Tanaka, Ryosuke Nishio, Tamotsu Mitsuiye, Akira Mizoguchi, Jiang Wang, Masayoshi Ishida, Hiroshi Hiai, Akira Matsumori, Nagahiro Minato and Tasuku Honjo :
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.,
Nature Medicine, Vol.9, No.12, 1477-1483, 2003.
(DOI: 10.1038/nm955,   PubMed: 14595408)
41.Yoshiko Iwai, Seigo Terawaki, Masaya Ikegawa, Taku Okazaki and Tasuku Honjo :
PD-1 inhibits antiviral immunity at the effector phase in the liver.,
The Journal of Experimental Medicine, Vol.198, No.1, 39-50, 2003.
(DOI: 10.1084/jem.20022235,   PubMed: 12847136)
42.Taku Okazaki, Yoshiko Iwai and Tasuku Honjo :
New regulatory co-receptors: inducible co-stimulator and PD-1.,
Current Opinion in Immunology, Vol.14, No.6, 779-782, 2002.
(DOI: 10.1016/S0952-7915(02)00398-9,   PubMed: 12413529)
43.Masayoshi Ishida, Yoshiko Iwai, Yoshimasa Tanaka, Taku Okazaki, Gordon J. Freeman, Nagahiro Minato and Tasuku Honjo :
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.,
Immunology Letters, Vol.84, No.1, 57-62, 2002.
(DOI: 10.1016/S0165-2478(02)00142-6,   PubMed: 12161284)
44.Yoshiko Iwai, Taku Okazaki, Hiroyuki Nishimura, Akemi Kawasaki, Hideo Yagita and Tasuku Honjo :
Microanatomical localization of PD-1 in human tonsils.,
Immunology Letters, Vol.83, No.3, 215-220, 2002.
(DOI: 10.1016/S0165-2478(02)00088-3,   PubMed: 12095712)
45.Yoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka, Taku Okazaki, Tasuku Honjo and Nagahiro Minato :
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.99, No.19, 12293-12297, 2002.
(DOI: 10.1073/pnas.192461099,   PubMed: 12218188,   CiNii: 80015562229,   Elsevier: Scopus)
46.Nobuo Kanazawa, Taku Okazaki, Hiroyuki Nishimura, Kei Tashiro, Kayo Inaba and Tasuku Honjo :
DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif.,
The Journal of Investigative Dermatology, Vol.118, No.2, 261-266, 2002.
(DOI: 10.1046/j.0022-202x.2001.01633.x,   PubMed: 11841542)
47.Taku Okazaki, Akito Maeda, Hiroyuki Nishimura, Tomohiro Kurosaki and Tasuku Honjo :
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.,
Proc Natl Acad Sci U S A., Vol.98, No.24, 13866-13871, 2001.
48.Yvette Latchman, Clive R. Wood, Tatyana Chernova, Divya Chaudhary, Madhuri Borde, Irene Chernova, Yoshiko Iwai, Andrew J. Long, Julia A. Brown, Raquel Nunes, Edward A. Greenfield, Karen Bourque, Vassiliki A. Boussiotis, Laura L. Carter, Beatriz M. Carreno, Nelly Malenkovich, Hiroyuki Nishimura, Taku Okazaki, Tasuku Honjo, Arlene H. Sharpe and Gordon J. Freeman :
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.,
Nature Immunology, Vol.2, No.3, 261-268, 2001.
(DOI: 10.1038/85330,   PubMed: 11224527)
49.Hiroyuki Nishimura, Taku Okazaki, Yoshimasa Tanaka, Kazuki Nakatani, Masatake Hara, Akira Matsumori, Shigetake Sasayama, Akira Mizoguchi, Hiroshi Hiai, Nagahiro Minato and Tasuku Honjo :
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice.,
Science, Vol.291, No.5502, 319-322, 2001.
(DOI: 10.1126/science.291.5502.319,   PubMed: 11209085)
50.Taku Okazaki, Yoshiko Iwai, Hiroyuki Nishimura and Tasuku Honjo :
The regulation of PD-1/PD-L1 pathway and autoimmune diseases.,
Activating and inhibitory immunoglobulin-like receptors, 211-214, 2001.
51.Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana Chernova, Hiroyuki Nishimura, Lori J. Fitz, Nelly Malenkovich, Taku Okazaki, Michael C. Byrne, Heidi F. Horton, Lynette Fouser, Laura Carter, Vincent Ling, Michael R. Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood and Tasuku Honjo :
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.,
The Journal of Experimental Medicine, Vol.192, No.7, 1027-1034, 2000.
(DOI: 10.1084/jem.192.7.1027,   PubMed: 11015443,   Elsevier: Scopus)
52.Ofer Mandelboim, Sally Kent, Daniel M. Davis, S. Brian Wilson, Taku Okazaki, Richard Jackson, David Hafler and Jack L. Strominger :
Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells.,
Proc Natl Acad Sci U S A., Vol.95, No.7, 3798-3803, 1998.
53.Shigeru Minoguchi, Yoshihito Taniguchi, Hisamune Kato, Taku Okazaki, Lothar J. Strobl, Ursula Zimber-Strobl, Georg W. Bornkamm and Tasuku Honjo :
RBP-L, a transcription factor related to RBP-Jkappa.,
Molecular and Cellular Biology, Vol.17, No.5, 2679-2687, 1997.
(DOI: 10.1128/MCB.17.5.2679,   PubMed: 9111338)
54.Noriko Sato, Yoshihiro Ogawa, Goro Katsuura, Tetsuo Tsuji, Hiroaki Masuzaki, Junko Hiraoka, Taku Okazaki, Mikio Tamaki, Minoru Hayase, Yasunao Yoshimasa, Shigeo Nishi, Kiminori Hosoda and Kazuwa Nakao :
Pathophysiological Significance of the Obese Gene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats.,
Endocrinology, Vol.138, No.3, 947-954, 1997.
(DOI: 10.1210/endo.138.3.4989,   PubMed: 9048594)
55.Taku Okazaki, Yoshihiro Ogawa, Naohisa Tamura, Kiyoshi Mori, Naohi Isse, Tomohiro Aoki, Julie M. Rochelle, Makoto M. Taketo, Michael F. Seldin and Kazuwa Nakao :
Genomic Organization, Expression, and Chromosomal Mapping of the Mouse Adrenomedullin Gene.,
Genomics, Vol.37, No.3, 395-399, 1996.
(DOI: 10.1006/geno.1996.0576,   PubMed: 8938454)
56.Kazuhiko Takaya, Yoshihiro Ogawa, Naohi Isse, Taku Okazaki, Noriko Satoh, Hiroaki Masuzaki, Kiyoshi Mori, Naohisa Tamura, Kiminori Hosoda and Kazuwa Nakao :
Molecular Cloning of Rat Leptin Receptor Isoform Complementary DNAs Identification of a Missense Mutation in Zucker Fatty (fa/fa) Rats.,
Biochemical and Biophysical Research Communications, Vol.225, No.1, 75-83, 1996.
(DOI: 10.1006/bbrc.1996.1133,   PubMed: 8769097)
57.Naohi Isse, Yoshihiro Ogawa, Naohisa Tamura, Hiroaki Masuzaki, Kiyoshi Mori, Taku Okazaki, Noriko Satoh, Michika Shigemoto, Yasunao Yoshimasa, Shigeo Nishi, Kiminori Hosoda, Johji Inazawa and Kazuwa Nakao :
Structural Organization and Chromosomal Assignment of the Human obese Gene.,
The Journal of Biological Chemistry, Vol.270, No.46, 27728-27733, 1995.
(PubMed: 7499240)
58.Yoshihiro Ogawa, Hiroaki Masuzaki, Naohi Isse, Taku Okazaki, Kiyoshi Mori, Michika Shigemoto, Noriko Satoh, Naohisa Tamura, Kiminori Hosoda, Yasunao Yoshimasa and Kazuwa Nakao :
Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.,
The Journal of Clinical Investigation, Vol.96, No.3, 1647-1652, 1995.
(DOI: 10.1172/JCI118204,   PubMed: 7657834,   Elsevier: Scopus)
59.Hiroaki Masuzaki, Yoshihiro Ogawa, Naohi Isse, Noriko Satoh, Taku Okazaki, Michika Shigemoto, Kiyoshi Mori, Naohisa Tamura, Kiminori Hosoda, Yasunao Yoshimasa, Hisato Jingami, Teruo Kawada and Kazuwa Nakao :
Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue.,
Diabetes, Vol.44, No.7, 855-858, 1995.
(PubMed: 7789654)

Review, Commentary:

1.Takumi Maruhashi and Taku Okazaki :
LAG-3によるヘルパーT細胞応答の選択的な抑制機構,
Experimental Medicine, Vol.37, No.6, 942-945, Mar. 2019.
2.Taku Okazaki :
PD-1研究の歴史と今後の展望 (特集 PD-1抗体治療への道),
KAGAKU, Vol.89, No.2, 117-124, Feb. 2019.
(CiNii: 40021783506)
3.Taku Okazaki :
Face of the Cover:Dr. Tasuku HONJO,
TRENDS IN THE SCIENCES, Vol.24, No.2, 2_3, 2019.
(DOI: 10.5363/tits.24.2_3,   CiNii: 130007666514)
4.Taku Okazaki :
PD-1 Research: History and Future Perspectives,
TRENDS IN THE SCIENCES, Vol.24, No.2, 2_8-2_14, 2019.
(DOI: 10.5363/tits.24.2_8,   CiNii: 130007666525)
5.Takumi Maruhashi and Taku Okazaki :
免疫チェックポイント分子LAG-3はMHCクラスII分子を構造に依存的に認識することによりヘルパーT細胞の応答を選択的に抑制する,
ライフサイエンス新着論文レビュー, Nov. 2018.
6.Taku Okazaki :
免疫チェックポイント分子LAG-3メカニズム解明から治療法を目指す,
日経サイエンス, Vol.49, No.1, 88-89, Nov. 2018.
7.Taku Okazaki :
ダイアの原石,
Experimental Medicine, Vol.36, No.19, 3259-3261, Nov. 2018.
8.Taku Okazaki and Il-mi Okazaki :
免疫寛容を標的とした抗体医薬によるがん免疫療法,
Experimental Medicine, Vol.36, No.11, 1836-1840, Jun. 2018.
9.Taku Okazaki :
システム免疫学,
Inflammation & Immunology, Vol.25, No.1, 1-2, Jan. 2017.
10.Taku Okazaki and Il-mi Okazaki :
Basic researches on cancer immunotherapy targeting inhibitory co-receptors,
Journal of Clinical and Experimental Medicine, Vol.256, No.7, 789-792, Feb. 2016.
11.Taku Okazaki and Il-mi Okazaki :
Regulation of autoimmunity and tumor immunity by immuno-inhibitory co-receptor, PD-1.,
Seikagaku, Vol.87, No.6, 693-704, Dec. 2015.
(PubMed: 26863747,   CiNii: 40020687374)
12.Taku Okazaki and Il-mi Okazaki :
Regulation of autoimmunity by PD-1,
Experimental Medicine, Vol.33, No.12, 1935-1940, Jul. 2015.
13.Taku Okazaki :
免疫応答のチェックポイント序,
Inflammation & Immunology, Vol.23, No.1, 1-2, Jan. 2015.
14.Taku Okazaki :
Regulation of Autoimmunity by PD-1,
細胞工学, Vol.33, No.10, 1032-1037, 2014.
(CiNii: 40020227254)
15.Taku Okazaki and Il-mi Okazaki :
免疫抑制受容体分指標的(PD-1とその関連分子),
Inflammation & Immunology, Vol.21, No.3, 189-194, 2013.
16.Il-mi Okazaki and Taku Okazaki :
癌,自己免疫病とPD-1,
Journal of Clinical and Experimental Medicine, Vol.245, No.3, 12353-12357, 2013.
17.Taku Okazaki and Il-mi Okazaki :
末梢性免疫寛容におけるPD-1とLAG-3の相乗性,
Infection, Inflammation & Immunity, Vol.41, No.4, 329-331, Jan. 2012.
18.Taku Okazaki and Il-mi Okazaki :
PD-1欠損マウス,
モデル動物利用マニュアル,疾患モデルの作製と利用—免疫疾患, 80-86, Jun. 2011.
19.Taku Okazaki and Il-mi Okazaki :
Immune regulation by PD=1,
Medical Science Digest, Vol.36, No.12, 1081-1084, Nov. 2010.
20.Taku Yoshida and Taku Okazaki :
PD-1欠損と自己免疫感受性遺伝子,
Inflammation & Immunology, Vol.15, No.6, 731-736, Nov. 2007.
21.Taku Okazaki :
PD-1と自己免疫疾患,
Molecular Medicine Vol.41 臨時増刊号 免疫2005, Vol.41, 323-333, Dec. 2004.
22.Taku Okazaki and Tasuku Honjo :
PD-1と自己免疫疾患,
The Medical Frontline, Vol.59, No.7, 1668-1672, Jul. 2004.
23.Taku Okazaki and Tasuku Honjo :
PD-1欠損マウスに発症する拡張型心筋症は,心筋型トロポニンIに対する自己抗体の異常産生が原因である,
Journal of Clinical and Experimental Medicine, Vol.208, No.11, 944-945, Mar. 2004.
24.Taku Okazaki and Tasuku Honjo :
PD-1欠損マウスと免疫異常,
Annual Review 免疫 2002, 298-305, Nov. 2001.
25.Taku Okazaki, 小川 佳宏, 田村 尚久 and 中尾 一和 :
アドレノメデュリンの遺伝子構造と染色体部位,
Journal of Clinical and Experimental Medicine, Vol.184, No.1, 10-14, Jan. 1998.

Proceeding of International Conference:

1.Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura, Shimizu Kenji and Taku Okazaki :
LAG-3 preferentially inhibits activation of CD4 T cells recognizing stable pMHCII by its conformation-dependent recognition of MHCII,
第47回日本免疫学会学術集会, Fukuoka, Dec. 2018.
2.Mizuno Reina, Daisuke Sugiura, Shimizu Kenji, Takumi Maruhashi, Il-mi Okazaki and Taku Okazaki :
PD-1 primarily targets TCR-signal in the inhibition of functional T cell activation,
第47回日本免疫学会学術集会, Fukuoka, Dec. 2018.
3.Okamura Hikari, Il-mi Okazaki, Shimizu Kenji, Takumi Maruhashi, Daisuke Sugiura, Mizuno Reina and Taku Okazaki :
Single-cell analysis of autoreactive T cells under the control of PD-1,
第47回日本免疫学会学術集会, Fukuoka, Dec. 2018.
4.Taku Okazaki, Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura and Shimizu Kenji :
LAG-3 regulates immunodominance and autoimmunity by its conformation-dependent recognition of MHCII,
第41回日本分子生物学会年会, Yokohama, Nov. 2018.
5.Taku Okazaki :
Regulation of autoimmunity and anti-cancer immunity by inhibitory co-receptors,
Asian Transplantation Week 2018 (ATW2018), Busan, Nov. 2018.
6.Taku Okazaki :
Singularity research in autoimmunity,
第56回日本生物物理学会年会, Okayama, Sep. 2018.
7.Taku Okazaki :
Cellular and molecular mechanisms of immune regulation by PD-1,
第46回日本免疫学会学術集会, 仙台市, Dec. 2017.
8.Hikari Okamura, Il-mi Okazaki, Kenji Shimizu, Takumi Maruhashi, Daisuke Sugiura and Taku Okazaki :
Single-cell analysis of autoreactive T cells under the control of PD-1,
第46回日本免疫学会学術集会, 仙台市, Dec. 2017.
9.Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura and Taku Okazaki :
Immuno-inhibitory co-receptor LAG-3 regulates immunodominance and autoimmunity by virtue of its conformation-dependent recognition of MHCII,
第46回日本免疫学会学術集会, 仙台市, Dec. 2017.
10.Taku Okazaki :
Regulation of autoimmunity and cancer immunity by inhibitory co-receptors,
The 14th Nikko International Symposium 2017, 下野市, Oct. 2017.
11.Natsumi Maeda, Takumi Maruhashi, Kenji Shimizu, Il-mi Okazaki and Taku Okazaki :
Glucocorticoids augment the expression and inhibitory function of PD-1,
The 11th International Symposium of the institute network, 徳島市, Jan. 2017.
12.Kenji Shimizu, Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki and Taku Okazaki :
Characterization of target genes of inhibitory co-receptor PD-1 by CAGE,
The 11th International Symposium of the institute network, 徳島市, Jan. 2017.
13.Kenji Shimizu, Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki and Taku Okazaki :
Characterization of target genes of inhibitory co-receptor PD-1 by CAGE,
The 26th Hot spring harbor international symposium, 福岡市, Nov. 2016.
14.Il-mi Okazaki and Taku Okazaki :
Phenotypic characterization of LAG-3 expressing cells,
International Congress of Immunology 2016, Melbourne, Aug. 2016.
15.Takeo Kajihara, Taku Okazaki, Il-mi Okazaki, Daisuke Sugiura and Takumi Maruhashi :
Inhibition of T cell activation by human LAG-3,
International Congress of Immunology 2016, Melbourne, Aug. 2016.
16.Takumi Maruhashi, Taku Okazaki, Il-mi Okazaki and Daisuke Sugiura :
Context-dependent inhibition of antigen-specific T cell activation by LAG-3,
International Congress of Immunology 2016, Melbourne, Aug. 2016.
17.Taku Okazaki :
Regulation of autoimmunity by immuno-inhibitory receptors.,
The 4th Bizan immunology symposium at the University of Tokushima, Jan. 2015.
18.Il-mi Okazaki and Taku Okazaki :
Genetic reconstitution of autoimmune diseases in mice.,
The 4th Bizan immunology symposium at the University of Tokushima, Jan. 2015.
19.Daisuke Sugiura and Taku Okazaki :
Molecular analyses of an inhibitory co-receptor, LAG-3.,
The 3rd Bizan immunology symposium at the University of Tokushima, Feb. 2014.
20.Taku Okazaki :
Regulation of autoimmunity by immuno-inhibitory receptors.,
The 3rd Bizan immunology symposium at the University of Tokushima, Feb. 2014.
21.Taku Okazaki :
Immuno-inhibitory receptors in the regulation of autoimmunity,
2013 SKKU International Symposium on Molecular Medicine, Feb. 2013.
22.Taku Okazaki :
Immuno-inhibitory receptors in the regulation of autoimmunity,
The Second Immunology Symposium at the University of Tokushima, Jan. 2013.
23.Il-mi Okazaki and Taku Okazaki :
Genetic reconstitution of autoimmunity in mice,
The Second Immunology Symposium at the University of Tokushima, Tokushima, Jan. 2013.
24.Il-mi Okazaki, Daisuke Sugiura, Suzuka Takahashi, Takeo Kajihara and Taku Okazaki :
Identification of new therapeutic targets by genetic dissection and reconstitution of autoimmune diseases in mice,
JST-CREST International Symposium, Jan. 2013.
25.Taku Okazaki :
Regulation of autoimmunity by immuno-inhibitory receptors,
International Symposium on Immunology, New horizons in immune system, Tokushima, Feb. 2012.
26.Taku Okazaki, Daisuke Sugiura, Il-mi Okazaki and Honjo Tasuku :
Identification of the causal gene of aida mouse, a newly established animal model of autoimmunity,
The 14th International Congress of Immunology, Aug. 2010.
27.Watanabe Norihiko, Kido Masahiro, Aoki Nobuhiro, Iwamoto Satoru, Nishimura Hisayo, Taku Okazaki, Honjo Tasuku and Chiba Tsutomu :
Mechanisms involved in the development of fatal autoimmune hepatitis,
The 14th International Congress of Immunology, Aug. 2010.
28.Sakai Shunsuke, Kawamura Ikuo, Tsuchiya Kohsuke, Taku Okazaki and Mitsuyama Masao :
PD-1 inhibitory receptor prevents immunopathological responses in murine tuberculosis,
The 14th International Congress of Immunology, Aug. 2010.
29.Kasagi Shimpei, Kawano Seiji, Morinobu Akio, Taku Okazaki, Honjo Tasuku, Hatachi Saori, Shimatani Shinichiro, Tanaka Yoshimasa, Minato Nagahiro and Kumagai Shunichi :
Anti-PD-1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice,
The 14th International Congress of Immunology, Aug. 2010.
30.Il-mi Okazaki, Jiang Fang, Honjo Tasuku and Taku Okazaki :
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-PD-1KO mice,
The 14th International Congress of Immunology, Aug. 2010.
31.Taku Okazaki, Daisuke Sugiura, Il-mi Okazaki and Honjo Tasuku :
Requirement of isotype-switched and somatically mutated autoantibodies for the development of autoimmune diseases in BALB/c-PD-1KO mice,
The 4th International Conference on B cells and Autoimmunity, Aug. 2010.
32.Taku Okazaki :
Negative regulation of T cells by inhibitory co-receptors.,
Symposium on recent advances in transplantation immunology., Nov. 2009.
33.Taku Okazaki :
PD-1 signal and immunological tolerance.,
Annual Symposium of the Korean Association of Immunologists., Nov. 2009.

Proceeding of Domestic Conference:

1.Taku Okazaki :
抑制性免疫補助受容体によるがん免疫と自己免疫の制御,
国立がん研究センターがん免疫セミナー, Mar. 2019.
2.Taku Okazaki :
抑制性免疫補助受容体によるがん免疫と自己免疫の制御,
バイオロジクスフォーラム第16回学術集会, Mar. 2019.
3.Taku Okazaki :
抑制性免疫補助受容体PD-1によるがん免疫と自己免疫の制御,
第60回日本消化器病学会大会(JDDW2018), Nov. 2018.
4.Shimizu Kenji and Taku Okazaki :
PD-1受容体による遺伝子発現変動の網羅的解析,
第97回蔵本免疫懇話会, Oct. 2018.
5.Taku Okazaki :
抑制性免疫補助受容体による自己免疫とがん免疫の制御,
第1回AIR (Angiogenesis & Immunology Research), Aug. 2018.
6.Taku Okazaki :
抑制性免疫補助受容体によるがん免疫と自己免疫の制御,
第25回四国四大学皮膚科講演会, Jul. 2018.
7.Taku Okazaki :
抑制性免疫補助受容体によるがん免疫と自己免疫の制御,
第25回マクロライド新作用研究会, Jul. 2018.
8.Mizuno Reina, Daisuke Sugiura, Shimizu Kenji, Takumi Maruhashi, Watada Mizuki, Il-mi Okazaki and Taku Okazaki :
PD-1によるT細胞機能制御における標的分子の解析,
第17回四国免疫フォーラム, Jun. 2018.
9.Taku Okazaki :
抑制性免疫補助受容体PD-1によるがん免疫と自己免疫の制御,
広島大学特別セミナー, Dec. 2017.
10.Taku Okazaki :
抑制性免疫補助受容体によるがん免疫と自己免疫の制御,
奈良先端技術大学特別セミナー, Dec. 2017.
11.Taku Okazaki :
抑制性免疫補助受容体PD-1によるがん免疫と自己免疫の制御,
第68回日本皮膚科学会中部支部学術大会, Oct. 2017.
12.Taku Okazaki :
Regulation of autoimmunity by minority cells,
第55回日本生物物理学会年会, Sep. 2017.
13.Taku Okazaki :
抑制性免疫補助受容体PD-1によるがん免疫と自己免疫の制御,
平成29年度文部科学省新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】若手支援技術講習会, Sep. 2017.
14.Hikari Okamura, Il-mi Okazaki and Taku Okazaki :
PD-1による自己反応性T細胞活性化制御機構の解析,
第16回四国免疫フォーラム, Jun. 2017.
15.Natsumi Maeda, Takumi Maruhashi, Kenji Shimizu, Il-mi Okazaki and Taku Okazaki :
Glucocorticoids augment the expression and inhibitory function of PD-1,
第45回日本免疫学会学術集会, Dec. 2016.
16.Kenji Shimizu, Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki and Taku Okazaki :
Characterization of target genes of inhibitory co-receptor PD-1 by CAGE,
第45回日本免疫学会学術集会, Dec. 2016.
17.Il-mi Okazaki, Kenji Shimizu and Taku Okazaki :
マイノリティ細胞の同定と解析による自己免疫疾患制御機構の解明,
第39回日本分子生物学会年会, Dec. 2016.
18.Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura and Taku Okazaki :
Establishment and maintenance of immune tolerance by immuno-inhibitory receptors,
第39回日本分子生物学会年会, Dec. 2016.
19.Taku Okazaki :
Elucidation of pathomechanisms of autoimmunity by minority cell research,
第54回日本生物物理学会年会, Nov. 2016.
20.Taku Okazaki :
抑制性免疫補助受容体PD-1による自己免疫とがん免疫の制御,
第89回日本生化学会大会, Sep. 2016.
21.Taku Okazaki :
免疫抑制受容体PD-1による自己免疫とがん免疫の制御,
第3回ゲノム創薬・医療フォーラムシンポジウム, Sep. 2016.
22.Taku Okazaki :
抑制性免疫補助受容体PD-1を標的としたがん免疫療法の基礎研究,
第220回日本呼吸器学会関東地方会, Jul. 2016.
23.Taku Okazaki :
抑制性免疫補助受容体PD-1による自己免疫とがん免疫の制御,
第4回免疫4次元空間ダイナミクス・サマースクール, Jul. 2016.
24.Natsumi Maeda and Taku Okazaki :
ケミカルバイオロジーによるPD-1の発現制御機構の解明,
第15回四国免疫フォーラム, Jun. 2016.
25.Kenji Shimizu and Taku Okazaki :
抑制性免疫補助受容体PD-1の標的遺伝子とその特徴,
第15回四国免疫フォーラム, Jun. 2016.
26.Taku Okazaki :
抑制性免疫補助受容体PD-1による自己免疫とがん免疫の制御,
第6回T cell camp, May 2016.
27.Takumi Maruhashi and Taku Okazaki :
Context-dependent inhibition of antigen-specific T cell activation by LAG-3,
The 5th Bizan Immunology Symposium, Mar. 2016.
28.Taku Okazaki :
免疫抑制受容体PD-1を標的としたがんと自己免疫疾患の治療,
京都大学学際融合教育研究推進センター生理化学研究ユニット第5回シンポジウム, Dec. 2015.
29.Taku Okazaki :
免疫抑制受容体PD-1による自己免疫とがん免疫の制御,
Immuno-Oncology Seminar, Dec. 2015.
30.Taku Okazaki :
免疫寛容を標的とした革新的がん治療薬:PD-1抗体,
第12回徳島大学医歯薬学研究部公開シンポジウム, Nov. 2015.
31.梶原 武雄, Daisuke Sugiura, 水野 玲奈, Deshani Chamila Ranawakage, 前田 菜摘, 清水 謙次, Il-mi Okazaki and Taku Okazaki :
Comparison of human and mouse LAG-3,
第44回日本免疫学会学術集会, Oct. 2015.
32.Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura, 梶原 武雄 and Taku Okazaki :
The strength of inhibition by LAG-3 depends on properties of APCs,
第44回日本免疫学会学術集会, Oct. 2015.
33.Taku Okazaki, Takumi Maruhashi, Daisuke Sugiura and Il-mi Okazaki :
Regulation of autoimmunity by PD-1 and LAG-3,
第44回日本免疫学会学術集会, Oct. 2015.
34.Taku Okazaki :
多機能複合分子標的物質の作製による細胞運命操作技術の開発,
革新的バイオ医薬品創出基盤技術開発事業ワークショップ, Oct. 2015.
35.Taku Okazaki :
免疫抑制受容体PD-1による自己免疫とがん免疫の制御,
Immuno-Oncology Seminar, Sep. 2015.
36.Taku Okazaki :
PD-1阻害抗体の免疫関連副作用,
第31回日本皮膚悪性腫瘍学会, Jul. 2015.
37.Taku Okazaki :
免疫抑制受容体PD-1による自己免疫と癌免疫の制御,
第12回LEGEND Seminar, Jul. 2015.
38.Taku Okazaki :
英語科学論文の執筆ーPD-1を標的としたがん免疫療法の話題とともにー,
生化学若い研究者の会中四国支部生命科学春セミナー, May 2015.
39.Taku Okazaki :
免疫抑制受容体による自己免疫とがん免疫の制御,
Immuno-Oncology Seminar, Apr. 2015.
40.Taku Okazaki :
免疫抑制受容体による自己免疫と癌免疫の制御,
第21回大阪大学微生物病研究所ブリッジセミナー, Mar. 2015.
41.Taku Okazaki :
免疫抑制受容体による自己免疫とがん免疫の制御,
第28回千葉基礎・臨床免疫セミナー, Nov. 2014.
42.Il-mi Okazaki, Daisuke Sugiura, Takumi Maruhashi, Takeo Kajihara and Taku Okazaki :
自己免疫疾患制御分子の同定による新規治療法の開発,
CREST「免疫機構」領域第三回シンポジウム, Oct. 2014.
43.Takeo Kajihara, Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki and Taku Okazaki :
ヒトLAG-3の機能解析,
第13回四国免疫フォーラム, Jun. 2014.
44.Taku Okazaki :
次世代免疫療法によるがんの治療,
徳島県皮膚悪性腫瘍学術講演会, Jun. 2014.
45.Taku Okazaki and Il-mi Okazaki :
免疫抑制シグナルの調節による自己免疫疾患の制御とがんの治療,
神戸薬科大学エクステンション事業 徳島生涯研修企画 第92回学術研修会, Feb. 2014.
46.Daisuke Sugiura, Il-mi Okazaki, 高橋 涼香, 梶原 武雄 and Taku Okazaki :
免疫抑制受容体LAG-3によるT細胞活性化制御機構の解析,
第12回四国免疫フォーラム, Jun. 2013.
47.Taku Okazaki :
免疫抑制受容体による免疫応答の制御,
第4回 東京編・徳島大学研究者との集い, Jul. 2012.
48.Taku Okazaki :
aidaマウスを用いた自己免疫疾患発症制御機構の解析,
第7回自己免疫疾患研究会, Jul. 2012.
49.Il-mi Okazaki, Daisuke Sugiura, Suzuka Takahashi, Takeo Kajihara and Taku Okazaki :
PD-1欠損マウスを用いた自己免疫疾患のゲノム解析,
第11回四国免疫フォーラム, Jun. 2012.
50.Taku Okazaki :
自己免疫疾患のゲノム解析,
第8回宮崎サイエンスキャンプ, Feb. 2012.
51.Taku Okazaki :
自己免疫疾患制御分子の同定による新規治療法の開発,
CREST「免疫機構」領域第二回シンポジウム, Sep. 2011.
52.Il-mi Okazaki, Daisuke Sugiura, Takahashi Suzuka and Taku Okazaki :
PD-1 and LAG-3 inhibitory coreceptors act synergistically to prevent autoimmunity in mice.,
第10回四国免疫フォーラム, Jun. 2011.
53.Taku Okazaki :
自己免疫病ゲノミクス,
愛媛大学プロテオ医学研究センター 学術シンポジウム「難病のプロテオゲノミクス」, Feb. 2011.
54.Taku Okazaki, Il-mi Okazaki and Daisuke Sugiura :
Aida, a newly established animal model of autoimmunity,
The Japanese Society for Immunology 2010 Symposium for Cutting edge of immunology; innate immunity and immune regulation, Dec. 2010.
55.Taku Okazaki :
免疫補助分子の機能解析による新規免疫制御剤の開発,
第3回革新的特色研究シンポジウム, Nov. 2010.
56.Taku Okazaki :
免疫抑制受容体PD-1による自己免疫疾患の制御,
第21回The Meeting of Liver and Immunology, Sep. 2010.
57.Taku Okazaki and Il-mi Okazaki :
PD-1 deficiency results in the development of fatal myocarditis in MRL mice.,
第9回四国免疫フォーラム, Jun. 2010.
58.Takeo Kajiwara, Daisuke Sugiura, Il-mi Okazaki and Taku Okazaki :
自己免疫性胃炎モデルマウスにおける自己抗原同定の試み,
第33回徳島県医学検査学会, Dec. 2009.
59.Sakai Shunsuke, Kawamura Ikuo, Tsuchiya Kohsuke, Taku Okazaki and Mitsuyama Masao :
The PD-1:PD-L co-inhibitory pathway is a critical determinant of host resistance to pulmonary tuberculosis.,
第39回日本免疫学会総会・学術集会, Vol.39, 243, Dec. 2009.
60.Kasagi Shinpei, Kawano Seiji, Taku Okazaki, Honjo Tasuku, Morinobu Akio, Hatachi Saori, Shimatani Kenichiro, Tanaka Yoshimasa, Minato Nagahiro and Kumagai Shunichi :
Anti-PD-1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.,
第39回日本免疫学会総会・学術集会, Vol.39, 160, Dec. 2009.
61.Taku Okazaki :
PD-1の腫瘍免疫における役割と免疫療法への展開,
中国・四国広域がんプロ養成コンソーシアムセミナー「がん免疫療法」, Oct. 2009.
62.Taku Okazaki :
自己免疫疾患のゲノム解析,
若手生命科学シンポジウム2009徳島, Aug. 2009.
63.Taku Okazaki :
自己免疫疾患のゲノム解析,
日本免疫学会 免疫サマースクール2009, Jul. 2009.
64.Taku Okazaki :
Genetic dissection and reconstitution of autoimmune diseases.,
Annual International Workshop on Mucosal Immunology and Vaccine for Young Investigators., Apr. 2009.
65.Taku Okazaki and Tasuku Honjo :
Genetic dissection and reconstitution of autoimmune diseases using PD-1 deficient mice.,
BMB2008, Dec. 2008.
66.Seigo Terawaki, Shunsuke Chikuma, Taku Okazaki and Tasuku Honjo :
Transcriptional mechanisms of mouse PD-1 gene.,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 234, Dec. 2008.
67.Shunsuke Chikuma, Seigo Terawaki, Taku Okazaki and Tasuku Honjo :
PD-1 induces T cell anergy by limiting autonomous IL-2 production.,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 234, Dec. 2008.
68.Shinpei Kasagi, Seiji Kawano, Akio Morinobu, Saori Hatachi, Kenichiro Shimatani, Yoshimasa Tanaka, Nagahiro Minato, Taku Okazaki, Tasuku Honjo and Shunichi Kumagai :
Involvement of IFN-g producing CD4+ PD-1+ T cells in lupus-prone NZB/W F1 mice.,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 233, Dec. 2008.
69.Shunsuke Sakai, Ikuo Kawamura, Ryosuke Uchiyama, Taku Okazaki and Masao Mitsuyama :
The PD-1:PD-L1 pathway inhibits the protective immunity and contributes to the bacterial persistence in mycobacterial infection.,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 159, Dec. 2008.
70.Yoshihiko Usui, Masaru Takeuchi, Youko Okunuki, Takeshi Kezuka, Takaaki Hattori, Juan Ma, Chiharu Nishiyama, Taku Okazaki, Tasuku Honjo, Hideo Yagita, Sunao Sugita, Hisaya Akiba and Hiroshi Goto :
Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine experimental autoimmune uveoretinitis (EAU).,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 94, Dec. 2008.
71.Masahiro Kido, Norihiko Watanabe, Taku Okazaki, Junya Tanaka, Akiyoshi Nishio, Tasuku Honjo and Tsutomu Chiba :
Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.,
The 38the Annual Meeting of the Japanese Society for Immunology, Vol.38, 92, Dec. 2008.
72.Taku Okazaki :
PD-1欠損マウスを用いた自己免疫疾患の遺伝解析,
第5回HBS公開シンポジウム, Nov. 2008.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 抑制性免疫補助受容体PD-1の新規制御メカニズムの解明 (Project/Area Number: 19H01029 )
  • 免疫とがんを支配するシンギュラリティ細胞の解明 (Project/Area Number: 18H05417 )
  • マウスにおける母仔遺伝的コンフリクト回避機構の解明 (Project/Area Number: 24113516 )
  • Identification of genes that regulate allergic diseases. (Project/Area Number: 24659151 )
  • 自己反応性B細胞の分化・機能成熟制御システムの解明 (Project/Area Number: 22021030 )
  • 肥満症と自己免疫疾患の相互作用に関する萌芽的研究 (Project/Area Number: 20659048 )
  • 新規自己免疫疾患原因遺伝子AIDAによる自己免疫疾患発症制御機構の解析 (Project/Area Number: 20060012 )
  • Apc・Smad4変異マウスを用いた臓器特異的発がん機序の解析 (Project/Area Number: 20012028 )
  • Genetic reconstitution of autoimmune diseases in mice. (Project/Area Number: 19689012 )
  • MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis. (Project/Area Number: 19591167 )
  • 標的経細胞におけるAID依存的RNA編集と自己免疫疾患感受性に関する萌芽的解析 (Project/Area Number: 18659138 )
  • The establishment and clinical application of new immunotherapy for gynecologic cancers by using the activation of self-tolerance (Project/Area Number: 18209052 )
  • apc変異マウスを用いた臓器特異性と遺伝子背景に関する分子遺伝学的解析 (Project/Area Number: 18012027 )
  • 自己免疫疾患感受性遺伝子の同定による自己免疾疾患の分子病態解析 (Project/Area Number: 17047024 )
  • 免疫抑制受容体PD-1の阻害による新規がん免疫療法の開発 (Project/Area Number: 17016041 )
  • PD-1欠損マウスを用いた自己免疫疾患の多重遺伝子変異解析 (Project/Area Number: 16689011 )
  • 自己免疫疾患抑制性B細胞の同定に関する萌芽的研究 (Project/Area Number: 16659085 )
  • 自己免疫疾患感受性遺伝子の網羅的探索による自己免疫疾患の分子病態解析 (Project/Area Number: 16043232 )
  • PD-1欠損マウスを用いた自己免疫疾患感受性遺伝子の網羅的探索 (Project/Area Number: 16012235 )
  • Search by Researcher Number (00362468)