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en: Synthesis of naphthalene-fused imidazo[1,2-a]pyridinium salts showing green luminescence with high quantum yields and large Stokes shift

en: We have synthesized naphthalene-fused imidazo[1,2-a]pyridines by a novel electrophilic iodocyclization of 2-alkynyl-3-arylimidazo[1,2-a]pyridines. Notably, their quaternized salts exhibited green emission with unexpectedly high quantum yields and mega-large Stokes shift and were successfully used for mitochondrial imaging.

en: Organic & Biomolecular Chemistry

ja: Organic & Biomolecular Chemistry


en: Blue Luminescent Boron Complexes Based on N,N-Type Imidazo[1,5-a]pyridine Ligand for Mitochondrial Imaging

en: Asian Journal of Organic Chemistry

ja: Asian Journal of Organic Chemistry


en: Mechanochemical transformation of tetraaryl[3]cumulenes to benzofulvenes via electrophilic iodocyclization

en: RSC Mechanochemistry

ja: RSC Mechanochemistry


en: Divalent metal complexes of N,O- and N,N-bidentate imidazo[1,5-a]pyridine ligands: Synthesis, crystal structures, and photophysical properties

en: Inorganica Chimica Acta

ja: Inorganica Chimica Acta


en: Precipitant-free Crystallization of Lysozyme and Glucose Isomerase by Drying

en: Protein crystallization is usually conducted by using precipitants, although the salting-out phenomenon is still unclear and complex. Moreover, the addition of precipitants sometimes results in irreversible disordered precipitation of protein molecules. Although precipitant-free lysozyme crystals obtained by centrifugal concentration showed significant changes in three-dimensional structure compared to the structure of salted-out crystals, it was rather difficult to mount crystals from a viscous dense liquid phase after centrifugal concentration, and the quality of the crystals often deteriorated during the mounting process. Here we present novel precipitant-free crystallization methods, which were effective for lysozyme and glucose isomerase. Tetragonal lysozyme crystals were successfully crystallized in a glass capillary simply by drying highly concentrated lysozyme solution in the presence of 0.01 M hydrochloric acid without using any precipitants. Glucose isomerase dissolved in ultra-pure water was also successfully crystallized in hanging drops by drying highly concentrated solution under low-humidity conditions. Oscillation images of the obtained crystals were safely collected without handling; they clearly indicated the crystals had a tetragonal form for lysozyme and an orthorhombic form for glucose isomerase, and their lattice parameters are similar to those of previously reported crystals obtained by salting-out methods.

en: Crystals

ja: Crystals


en: Unexpected Formation of Poly-Functionalized Fulvenes by Reaction of a Tetraaryl[5]cumulene with Iodine


en: Facile Construction of Benzofulvene Scaffold from Tetraaryl[3]cumulene via Electrophilic Iodocyclization

en: European Journal of Organic Chemistry

ja: European Journal of Organic Chemistry


en: 導入教育としての物性測定装置作製の取組

ja: 導入教育としての物性測定装置作製の取組

en: 徳島大学技術支援部技術報告

ja: 徳島大学技術支援部技術報告


en: One-pot synthesis of novel polysubstituted 1,1-phenylene-bipyrrole via the double [3+2] cycloaddition reaction

en: Tetrahedron

ja: Tetrahedron


en: Regioisomeric Allene Dimer Formation by the Reaction of Tetraarylbutatrienes with Tetracyanoethene

en: The reaction of tetraarylbutatrienes (tetraaryl[3]cumulenes) with tetracyanoethene (TCNE), a strong electron-accepting molecule, at room temperature yielded novel four-membered ring compounds (head-to-tail unsymmetrically substituted diarylallene dimers) by [2 + 2] cycloaddition of the central C[double bond, length as m-dash]C bond of the butatrienes. This reaction proceeded through a head-to-head symmetrically substituted diarylallene dimer intermediate. Unsymmetrical butatriene also formed a small amount of another head-to-tail dimer. Although the allene dimer is stable in nonpolar solvents, it converts to other bicyclic and tricyclic compounds in MeOH or CH3CN at room temperature.


en: Action of reactive oxygen species in the antifungal mechanism of gemini-pyridinium salts against yeast

en: We previously found that the gemini quaternary salt (gemini-QUAT) containing two pyridinium residues per molecule, 3,3'- (2,7-dioxaoctane) bis (1-decylpyridinium bromide) (3DOBP-4,10) , exerted fungicidal activity against Saccharomyces cerevisiae and caused respiration inhibition and the cytoplasmic leakage of ATP, magnesium, and potassium ions. Here, we investigated how the gemini-QUAT, 3DOBP-4,10, exerts more powerful antimicrobial activity than the mono-QUAT N-cetylpyridinium chloride (CPC) and examined the association between reactive oxygen species (ROS) and the antimicrobial mechanism. Antifungal assays showed that the activity of 3DOBP-4,10 against two yeasts, S. cerevisiae and Candida albicans, was significantly elevated under aerobic conditions, and largely reduced under anaerobic conditions (nitrogen atmosphere) . Adding radical scavengers such as superoxide dismutase, catalase and potassium iodide (KI) also decreased the fungicidal activity of 3DOBP-4,10 but negligibly affected that of CPC. We measured survival under static conditions and found that the rapid fungicidal profile of 3DOBP-4,10 was lost, whereas that of CPC was slightly affected in the presence of KI. Our results suggest that 3DOBP-4,10 exerts powerful antimicrobial activity by penetrating the cell wall and membrane, which then allows oxygen to enter the cells, where it participates in the generation of intracellular ROS. The activity could thus be attributable to a synergic antimicrobial combination of the disruption of organelle membranes by the QUAT and oxidative stress imposed by ROS.

en: Biocontrol Science

ja: Biocontrol Science


en: Novel Pentacycles Exhibiting Strong Blue Emission in the Solid State

en: LED総合フォーラム2018 in 徳島 論文集

ja: LED総合フォーラム2018 in 徳島 論文集


en: 単結晶X線構造解析による特異な環状有機化合物の構造決定

ja: 単結晶X線構造解析による特異な環状有機化合物の構造決定

en: Tetracyanoethene

ja: 大学院理工学研究部総合技術センター 技術報告


en: 自動滴定装置の開発・改良を通じた 化学分野におけるものづくり教育の探究

ja: 自動滴定装置の開発・改良を通じた 化学分野におけるものづくり教育の探究

en: 徳島大学大学院ソシオテクノサイエンス研究部総合技術センター 技術報告

ja: 徳島大学大学院ソシオテクノサイエンス研究部総合技術センター 技術報告


en: 粒度分布測定装置の開発を通じた化学におけるものづくり教育の研究

ja: 粒度分布測定装置の開発を通じた化学におけるものづくり教育の研究

en: 徳島大学大学院ソシオテクノサイエンス研究部総合技術センター 技術報告

ja: 徳島大学大学院ソシオテクノサイエンス研究部総合技術センター 技術報告


en: Precipitant-free lysozyme crystals grown by centrifugal concentration reveal structural changes

en: The three-dimensional (3D) structure of a protein molecule in its crystal need not correspond to that found in vivo in many cases, since we usually crystallize protein molecules using precipitants (salts, organic solvents, polymeric electrolytes, etc.), and the precipitants are often incorporated into crystals along with the protein molecules. Although precipitant-free crystallization methods would solve these problems, such methods had not yet been established. We have achieved a novel precipitant-free crystallization method by liquid-liquid phase separation during the centrifugal concentration of lysozyme in ultra-pure water. In the 3D structure of the precipitant-free crystal, lysozyme loses a sodium cation and changes the position of Ser 72. Deionization of the solution also appears to induce a change in the position of Asp 101 and an increase in the activity of lysozyme.

en: Crystal Growth & Design

ja: Crystal Growth & Design