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en: Diversity and differentiation pathways of medullary thymic epithelial cells

ja: 胸腺髄質上皮細胞の多様性と分化経路

en: Clinical Immunology & Allergology

ja: 臨床免疫·アレルギー科


en: The role of thymic epithelium in thymus development and age-related thymic involution.

en: The establishment of an adaptive immune system is critical for protecting our bodies from neoplastic cancers and invading pathogens such as viruses and bacteria. As a primary lymphoid organ, the thymus generates lymphoid T cells that play a major role in the adaptive immune system. T cell generation in the thymus is controlled by interactions between thymocytes and other thymic cells, primarily thymic epithelial cells. Thus, the normal development and function of thymic epithelial cells are important for the generation of immunocompetent and self-tolerant T cells. On the other hand, the degeneration of the thymic epithelium due to thymic aging causes thymic involution, which is associated with the decline of adaptive immune function. Herein we summarize basic and current knowledge of the development and function of thymic epithelial cells and the mechanism of thymic involution. J. Med. Invest. 71 : 29-39, February, 2024.

en: The Journal of Medical Investigation : JMI


en: Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells

en: Thymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8 cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cells and medullary thymic epithelial cells. Here we summarize the role of these two tissue-specific proteasomes, focusing on their functions in the development of CD8 T cells in the thymus.

en: Current Opinion in Immunology

ja: Current Opinion in Immunology


en: 胸腺プロテアソームとTCRレパトア選択

ja: 胸腺プロテアソームとTCRレパトア選択


en: 胸腺上皮細胞の動態:胎生期での発生，成体での維持，加齢に伴う退縮

ja: 胸腺上皮細胞の動態:胎生期での発生，成体での維持，加齢に伴う退縮

en: 胸腺上皮細胞は，非自己に応答し，自己に寛容なT細胞レパトア形成をになう胸腺微小環境を構築する主要な細胞である．胸腺上皮細胞は，それぞれ皮質と髄質の微小環境を構成する胸腺皮質上皮細胞と胸腺髄質上皮細胞に分類され，これらの上皮細胞は，胎生期に，内胚葉由来の上皮共通前駆細胞から分化する．近年，胸腺上皮細胞の分化と維持，および，胸腺退縮における胸腺上皮細胞の変化について，そのメカニズムが明らかにされつつある．そこで本稿では，これらの胸腺上皮細胞の動態について，最新の知見を紹介する．

en: Inflammation & Immunology

ja: 炎症と免疫


en: Thymoproteasome optimizes positive selection of CD8+ T cells without contribution of negative selection

en: Advances in Immunology

ja: Advances in Immunology


en: The role of proteasomes in the thymus

ja: The role of proteasomes in the thymus

en: Frontiers in Immunology

ja: Frontiers in Immunology


en: Generation of diversity in thymic epithelial cells

en: In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells. Here, we review the expanding diversity in TEC subpopulations in relation to their functions in T cell development and selection as well as their origins and development.

en: Nature Reviews. Immunology

ja: Nature Reviews. Immunology


en: T細胞の自己寛容を確立する胸腺髄質微小環境

ja: T細胞の自己寛容を確立する胸腺髄質微小環境

en: 自己免疫疾患の発症機構と治療 実験医学増刊号

ja: 自己免疫疾患の発症機構と治療 実験医学増刊号


en: XCL1と胸腺におけるnTregの生成

ja: XCL1と胸腺におけるnTregの生成

en: Infection, Inflammation & Immunity

ja: 感染·炎症·免疫


en: Thymic cortical epithelial cells specific expression of thymoproteasome

ja: 胸腺プロテアソームの胸腺皮質上皮細胞特異的発現

en: Clinical Immunology & Allergology