Idiopathic First Bite Syndrome Well-Treated with the Japanese Herbal Medicine Kakkonto: Analysis of Heart Rate Variability.


Personal Identification from Dental Findings Using AI and Image Analysis against Great Disaster in Japan

本稿では，南海トラフに備え歯科的所見を自動的にデータベースに保存システムを提案する．東日本大震災では被害者の身元を確認するために約2600人の歯科医師が約8750件の歯科診療所見を集め，1250人の遺体の身元を判明させたが，多大な時間と労力が必要であった．本手法では，口腔内のカメラ映像と3Dスキャナによる3DデータとパノラマX線画像を組み合わせることで，デンタルチャートを自動生成することが可能である．


Using dental records in personal identification

災害時の被害者の身元の判別に歯科所見を使用することは有力な方法のひとつであり，東日本大震災では被害者の約1割が歯科所見で身元を判別された．しかし南海トラフでは32万に犠牲者が出るとも言われており，医師不足が予想されている．そこで本稿では，画像処理により，口腔内のカメラ画像とパノラマX線画像から自動診断により生成したデンタルチャートを医療ネットワークにデータを蓄積するシステムを提案した．


Primary Glossodynia Well-Treated with Triple-Drug Combination: A Case Series

三剤併用が奏効した一次性舌痛症の3例

Primary glossodynia is characterized by abnormal sensations such as tongue pain without pathological changes and is not fully understood. Primary glossodynia is reported to be associated with neurophathic pain. We describe the cases of 3 patients(2 males, 1 female, mean age 54.3 years, range 42-79 years) with primary glossodynia that was treated with the concomitant medication of pregabalin (50-300mg/day), tramadol hydrochloride/acetaminophen tablets (37.5/325-150/1,300mg/day), and powdered processed aconite roots (0.5-1.5mg/day). This medication remarkably relieved the patients primary glossodynia and promoted health-reated quality of life of them. Significant adverse events did not occur in any of the cases.<br>This concomitant medication may be useful for the treatment of primary glossodynia.

一次性舌痛症は舌に痛みなどの異常感を訴えるものの，器質的または精神的要因のいずれも見出せないものとされる．近年，本症と神経障害性疼痛との関連が論じられている．今般，われわれはプレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠および加工附子末製剤の三剤併用が奏効した本症の3例を経験したので，その概要を報告する．患者は男性2名，女性1名，年齢42∼79歳(平均54.3歳)であった．全例に対してこれら三剤を併用した．痛みは緩解し，健康関連QOLも向上した．特記すべき有害事象は認められなかった．本症に対するこれら三剤併用の有用性が示唆された．


The development of personal identification method by image analysis technology of dentition

大規模災害時の被害者の判別に歯科データが使用されることが多い．生前と死後のデータを照合するには標準化されたデータが必要となるが，生前のデータベース作成にも非常に多くの時間がかかる．そこで本稿では歯科用カルテを自動生成する手法を提案する．本手法はカメラで撮影される口腔内画像とレントゲン画像から画像処理と人工知能によりカルテを自動生成することで，データ収集と解析時間を革新的に短くできる．


Effectiveness of Kampo Medicines against Intractable Stomatitis: A Mini-Review

International Journal of Medical and Dental Sciences


Oral Lichen Planus Well-Treated with Kampo Medicines: Two Case Reports

IOSR Journal of Dental and Medical Sciences


A Case of Well-Managed Sarcoidosis with Cardiac Autonomic Dysfunction during Dental Therapy: Significance of Heart Rate Variability Analysis.


Concomitant Pregabalin and Tramadol Hydrochloride/Acetaminophen Formulation Relieved Neuropathic Itch of Gingiva: A Case Report.


A Case of Well-Managed Fibromyalgia with Autonomic Dysfunction during Dental Therapy: Significance of Heart Rate Variability Analysis


一次性舌痛症における唾液アミラーゼ活性測定の試み

一次性舌痛症における唾液アミラーゼ活性測定の試み

Journal of Japanese Society for Evidence and the Dental Professional


Recurrent Aphthous Stomatitis Well-Treated with Inchinkoto: Two Case Reports


Docetaxel・γ-tocotrienol併用療法による口腔癌移植ヌードマウス腫瘍への抗腫瘍効果の検討．

The Japanese Journal of Tissue Culture Society for Dental Research


五苓散と加工附子末製剤の併用が奏効した三叉神経痛の1例

五苓散と加工附子末製剤の併用が奏効した三叉神経痛の1例


徳島大学病院歯科診療所を受診したHIV感染症患者の臨床統計的検討

徳島大学病院歯科診療所を受診したHIV感染症患者の臨床統計的検討

Journal of Japanese Society of Dentistry for Medically Compromised Patient


A Case Series of Xerostomia Treated with Kampo Medicines: Assessment of Health-Related Quality of Life Based on the Japanese Version of the Short Form-8 Health Survey


Orofacial Pain Well-Treated with Triple-Drug Combination : A Case Series

三剤併用が奏効した口腔顔面痛の3例


Glossopharyngeal Neuralgia Caused by Diabetes Mellitus

糖尿病神経障害と診断された舌咽神経痛の一症例


Usability Survey on New Oral Care Products, Pepti-Sal Series

新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査


口腔ならびに呼吸器症状を呈した歯科用金属によるアレルギーの1例

口腔ならびに呼吸器症状を呈した歯科用金属によるアレルギーの1例


Effects of perioperative oral management in thoracoscopic lung lobectomy : Retrospective study

胸腔鏡下肺葉切除術における周術期口腔機能管理の効果に関する検討―後ろ向き研究―


Significance of Time-Domain Measurements of Heart Rate Variability in Burning Mouth Syndrome


A Case of Well-Managed Idiopathic Autonomic Neuropathy during Dental Therapy: Significance of Heart Rate Variability Analysis


Severe Posterior Open Bite by Posterior Folding of the Retrodiscal Tissue: A Case Report

IOSR Journal of Dental and Medical Sciences


Cerebellopontine Angle Mass Mimicking Lingual Nerve Injury after Dental Implant Placement: A Case Report.

This is a rare case report of a cerebellopontine angle (CPA) mass mimicking lingual nerve injury after a dental implant placement. Lingual nerve injury is a common complication following dental implant placement. CPA masses are likely to cause symptomatic trigeminal neuralgia, and thus can mimic and be easily confused with oral diseases. We experienced a case of CPA mass mimicking lingual nerve injury after dental implant placement. The patient was a 57-year-old Japanese female and complained of glossalgia. She underwent dental implant placement in the mandible before visiting our clinic. Panoramic x-ray radiography revealed no abnormalities; the salivary flow rate by gum test was 7.0 ml/10 min. She was diagnosed with lingual nerve injury and secondary burning mouth syndrome. Vitamin B12 and oral moisturizer did not provide relief; furthermore, numbness in the lower lip emerged. A Semmes Weinstein test demonstrated elevation of her sensitivity threshold. Finally, magnetic resonance imaging revealed a 20-mm-diameter mass in the CPA. The patient is now being followed under conservative management. Our experience underscores the importance of including CPA mass in the differential diagnosis of dental diseases. This article is protected by copyright. All rights reserved.


Pregabalin Relieved Gingival Pruritus Associated with Oral Dysesthesia: A Case Report


脊髄損傷後片麻痺の後遺を有する患者に生じた口底癌の1例

脊髄損傷後片麻痺の後遺を有する患者に生じた口底癌の1例


Study on Health-Related Quality of Life in Patients with Primary Glossodynia : Using the Japanese Version of the MOS 36-Item Short-Form Health Survey Version 2

一次性舌痛症に関する健康関連QOLの調査-MOS 36-Item Short-Form Health Survey Version 2日本語版を用いて-

Primary glossodynia is characterized by abnormal sensations such as tongue pain without pathological changes and is not fully understood. The Japanese version of the MOS 36-item short-form health survey version 2 (SF-36v2) is a questionnaire to measure health-related quality of life (HRQoL) in various diseases. We studied HRQoL in 26 primary glossodynia patients who self-completed the SF-36v2. The mean scores on the SF-36v2 subscales in our female patients were significantly lower than the national norms. Furthermore, those in the elderly female patients were significantly lower than those in the middle-aged ones. Conditions of primary glossodynia in the elderly patients were complicated by physical and mental factors; psychosocial supports should be required for their care in addition to pain control. Our study of HRQoL in primary glossodynia patients using the SF-36v2 was shown to be meaningful for understanding primary glossodynia and establishing goals for its care.

一次性舌痛症は舌痛を訴えるものの確たる要因を見出せず，未だ十分な理解には達していない．MOS 36-Item Short-Form Health Survey Version 2 (SF-36v2)日本語版は健康関連QOL(Health-Related Quality of Life)の尺度である．今般，われわれはSF-36v2日本語版を用いて本疾患に関する健康関連QOLを調査した．2007年1月から2014年12月までに徳島大学病院口腔内科を受診した一次性舌痛症患者26名を対象とした．女性は男性と比較して，総じてSF-36v2下位尺度のスコアが低下し，高齢者では顕著であった．本疾患の病態は加齢によって複雑化し，高齢者に対する治療目標は疼痛だけに固執せず，心理・社会的問題に対する配慮も要すると考えられた．SF-36v2日本語版による健康関連QOLの調査は本疾患の理解と治療目標の設定において有意義であった．

Journal of Japanese Society of Oral Medicine


A Case Series of Burning Mouth Syndrome Treated with Stellate Ganglion Near-Infrared Irradiation: Assessment of HealthRelated Quality of Life Based on the Japanese Version of the MOS 36-Item Short-Form Health Survey Version 2


Well-Managed Postural Orthostatic Tachycardia Syndrome during Dental Therapy and Analysis of Heart Rate Variability: A Case Report

IOSR Journal of Dental and Medical Sciences


γ-tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2

Chemotherapy induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ tocotrienol on the 5 FU induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5 FU and γ tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5 FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene rated by 5 FU treatment, because N acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ tocotrienol. Whereas 5 FU stimulated the expression of NF E2 related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5 FU induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2 dependent antioxidant genes, such as heme oxygenase 1 (HO 1) and NAD(P)H:quinone oxidoreductase 1 (NQO 1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ tocotrienol could prevent 5 FU induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes.


Current Status and Problems Regarding the Perioperative Oral Function Management in the Tokushima University Hospital

徳島大学病院における周術期口腔機能管理の現状と課題

It has been shown that oral hygiene affects the onset of perioperative complications. The usefulness of perioperative oral function management aiming at the outbreak decrease in treatment complications and an early discharge was recognized. As a result, perioperative oral function management fee was founded at revision of medical service fees in Fiscal year 2012. In this clinical study, we evaluated the implementation of perioperative oral function management in Tokushima University Hospital. We examined 781 patients, including 563 patients for surgery and 218 patients for chemotherapy and radiotherapy. The mean age of patients was 58.8 ± 12.4 years old. The implementation rate of perioperative oral function management was 9.7% in the patients of surgery, and 17.4% in those of chemotherapy and radiotherapy. The highly required medical department was neurosurgery in the patients of surgery, and hematology in those of chemotherapy and radiotherapy. The mean number of tooth present was 21.3 ± 7.1 in the patients of surgery, and 19.8 ± 7.2 in those chemotherapy and radiotherapy. The rate of dental treatment was required in 40.5% of total patients who received surgery, and in 51.4% of patients who received chemotherapy and radiotherapy.The rate of patients who received denture treatment attained to 11.9% of the whole patients receiving surgery, and 13.3% of patients receiving chemotherapy and radiotherapy. It was revealed that there were many patients required potential demands in perioperative oral function management, and that there were many patients who need dental or denture treatment. We would like to develop perioperative oral function management by the interprofessional collaboration in health and social care.7月発行だが，6月号である．


口腔癌担癌ヌードマウスに対するdocetaxelおよびγ-tocotrienolの併用による抗腫瘍効果の検討


徳島大学病院脳卒中センターにおける口腔管理の意義について

徳島大学病院脳卒中センターにおける口腔管理の意義について


High-Wattage Pulsed Irradiation of Linearly Polarized Near-Infrared Light to Stellate Ganglion Area for Burning Mouth Syndrome

The purpose of this study was to apply high-wattage pulsed irradiation of linearly polarized near-infrared light to the stellate ganglion area for burning mouth syndrome (BMS) and to assess the efficacy of the stellate ganglion area irradiation (SGR) on BMS using differential time-/frequency-domain parameters (D parameters). Three patients with BMS received high-wattage pulsed SGR; the response to SGR was evaluated by visual analogue scale (VAS) representing the intensity of glossalgia and D parameters used in heart rate variability analysis. High-wattage pulsed SGR significantly decreased the mean value of VAS in all cases without any adverse event such as thermal injury. D parameters mostly correlated with clinical condition of BMS. High-wattage pulsed SGR was safe and effective for the treatment of BMS; D parameters are useful for assessing efficacy of SGR on BMS.


Orthostatic Dysregulation during Postural Change on the Dental Chair and Intraoperative Monitoring by Heart Rate Variability Analysis.

This is the first case report of orthostatic dysregulation (OD) manifested during postural change on the dental chair and intraoperatively monitored by heart rate variability (HRV) analysis. OD-associated autonomic dysfunction is induced by postural changes and easily leads to disturbance in circulatory dynamics; however, most dental practices have not yet realized the importance of managing OD. We measured autonomic activity in a patient with OD during dental therapy and assessed the clinical significance of HRV analysis for OD. The patient was a 17-year-old Japanese female. She was diagnosed with impacted wisdom teeth and had no previous history of a distinct systemic disease. A surgical procedure to extract the teeth was safely performed under both local anesthesia and sedation with nitrous oxide and midazolam. After the surgery, her postural change to sitting induced orthostatic hypotension. HRV variables showed parasympathetic dominance due to the upright position. Subsequently, her posture was returned to supine, and atropine sulfate administration for the immediate treatment of OD returned her blood pressure to normal levels. HRV variables showed relative sympathetic dominance due to an atropine-derived parasympathetic blockade. HRV analysis revealed OD-associated autonomic dysfunction and should become a standard tool for safe and secure dental management of OD.


いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について

いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について


A Case of Malignant Lymphoma of the Mandible Diagnosed by Coincidentally-Developed Mental Hypoesthesia after Dental Implant Placement

インプラント埋入後に生じたオトガイ神経麻痺が契機となり診断に至った下顎骨悪性リンパ腫の1例

We present a case of malignant lymphoma of the mandible diagnosed by coincidentally-developed mental hypoesthesia after placement of a dental implant. A 60-year old woman who underwent dental implant placement by a dental practitioner visited our hospital because of postoperative mental hypoesthesia. Orthopantomography and CT revealed perforated bone defects at the posterior molar and ramus region of the mandible, but could not demonstrate a causal relationship between the implantation and the hypoesthesia. In blood test results, the values of sIL-2R and LDH were abnormally elevated. A tumor arising from soft tissue around the molar region was biopsied, and a diagnosis of diffuse large B-cell lymphoma was confirmed histopathologically. This tumor was treated at the Department of Hematology by the R-CHOP chemotherapy regimen, resulting in complete remission of the tumor, and masticatory function was adequately restored using dental implants. It was concluded that early detection and rapid cure are the key to maintaining oral function.

Journal of Japanese Society of Oral Implantology

日本口腔インプラント学会誌


一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-

一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-

日本歯科人間ドック学会誌

日本歯科人間ドック学会誌


A case of acquired hemophilia A incidentally diagnosed on postoperative bleeding after tooth extraction

抜歯後の止血困難をきっかけに発見された後天性血友病Aの1例

Acquired hemophilia A is a rare disease. It is caused by the acquirement of factor VIII inhibitor. We report a case of acquired hemophilia A incidentally diagnosed on bleeding after tooth extraction. A 75-yearold woman referred to our hospital because of bleeding after tooth extraction. Hematological examination revealed a prolonged activated partial thromboplastin time (APTT) and decreased coagulation activity of factor VIII. In addition, a high level of factor VIII inhibitor was detected. Therefore, our patient was given a diagnosis of acquired hemophilia A. The patient was admitted to our hospital and received corticosteroids and bypass hemostasis using recombinant coagulation factor VII. On hospital day 42, APTT and factor VIII activity returned to the normal range. Moreover, factor VIII inhibitor disappeared. The patient was discharged and is being treated at a local general hospital.

Japanese Journal of Oral & Maxillofacial Surgery


Prevention of the destruction of acinar structure in patients with Sjogren's syndrome : Clinicopathological study on the effectiveness of cepharanthin

Sjogren症候群患者の唾液腺腺房構造破壊阻止 : セファランチンの有効性に関する臨床病理学的研究

Sjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS.
Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth.
Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases.
These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS.

Journal of The Japanese Stomatological Society


A case of oral, pharyngeal, esophageal, and gastric ulcer in a patient with primary macroglobulinemia showing remission by treatment with rituximab

リツキシマブの投与によって生じた口腔・上部消化管潰瘍の1例


口腔白板症の臨床病理学的検討-悪性化に関する臨床病理学的指標について-

口腔白板症の臨床病理学的検討-悪性化に関する臨床病理学的指標について-

Journal of Japanese Society for Evidence and the Dental Professional


Current state of request for Oral Care in the Tokushima University Hospital

徳島大学病院内の口腔ケア依頼状況


Frequency analysis of heart rate variability: a useful assessment tool of linearly polarized near-infrared irradiation to stellate ganglion area for burning mouth syndrome.

Burning mouth syndrome (BMS) is characterized by the following subjective complaints without distinct organic changes: burning sensation in mouth or chronic pain of tongue. BMS is also known as glossodynia; both terms are used equivalently in Japan. Although the real cause of BMS is still unknown, it has been pointed out that BMS is related to some autonomic abnormality, and that stellate ganglion near-infrared irradiation (SGR) corrects the autonomic abnormality. Frequency analysis of heart rate variability (HRV) is expected to be useful for assessing autonomic abnormality. This study investigated whether frequency analysis of HRV could reveal autonomic abnormality associated with BMS, and whether autonomic changes were corrected after SGR. Eight subjects received SGR; the response to SGR was assessed by frequency analysis of HRV. No significant difference of autonomic activity concerning low-frequency (LF) norm, high-frequency (HF) norm, and low-frequency/high-frequency (LF/HF) was found between SGR effective and ineffective groups. Therefore, we proposed new parameters: differential normalized low frequency (D LF norm), differential normalized high frequency (D HF norm), and differential low-frequency/high-frequency (D LF/HF), which were defined as differentials between original parameters just before and after SGR. These parameters as indexes of responsiveness of autonomic nervous system (ANS) revealed autonomic changes in BMS, and BMS seems to be related to autonomic instability rather than autonomic imbalance. Frequency analysis of HRV revealed the autonomic instability associated with BMS and enabled tracing of autonomic changes corrected with SGR. It is suggested that frequency analysis of HRV is very useful in follow up of BMS and for determination of the therapeutic efficacy of SGR.


γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the down regulation of the expression of NF-kB-regulated anti-apoptotic gene products.

Taxanes, including docetaxel, are widely used for the treatment of squamous cell carcinoma of the head and neck. However, the gastrointestinal toxicity of docetaxel has limited its high-dose clinical use. In this study, we examined the synergistic anticancer effects of combined low-dose docetaxel and γ-tocotrienol treatment on human oral cancer (B88) cells. We treated B88 cells with docetaxel and γ-tocotrienol at concentrations of 0.5 nM and 50 µM, respectively. When cells were treated with either agent alone at a low dose, no significant cytotoxic effect was observed. However, the simultaneous treatment of cells with both agents almost completely suppressed cell growth. Whereas docetaxel stimulated the expression of nuclear factor-κB (NF-κB) p65 protein in B88 cells, γ-tocotrienol slightly inhibited the expression of constitutive nuclear p65 protein. Of note, the combined treatment with both agents inhibited docetaxel-induced nuclear p65 protein expression. Electrophoretic mobility shift assay (EMSA) revealed that the simultaneous treatment with these agents suppressed the NF-κB DNA binding activity in B88 cells. In addition, γ-tocotrienol downregulated the docetaxel-induced expression of NF-κB-regulated gene products associated with the inhibition of apoptosis. Furthermore, the activation of initiator caspases, caspases-8 and -9, and the effector caspase, caspase-3, was detected following treatment with both agents. Finally, apoptosis was also clearly observed as demonstrated by the cleavage of poly(ADP-ribose) polymerase (PARP) and nuclear fragmentation through the activation of caspase-3 by combined treatment with docetaxel and γ-tocotrienol. These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.


イムノクロマト法による口腔カンジダ症迅速診断の臨床的有用性

イムノクロマト法による口腔カンジダ症迅速診断の臨床的有用性


精神科神経科入院患者の口腔環境評価と専門的口腔ケアの有用性について

精神科神経科入院患者の口腔環境評価と専門的口腔ケアの有用性について


徳島大学病院精神科神経科入院患者に対する口腔ケアの意義

徳島大学病院精神科神経科入院患者に対する口腔ケアの意義


Adrenergic urticaria and glossalgia induced by stress during dental therapy and monitored by heart variability analysis: A case report

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology


Clinical Statistics of Patients with Lingual Abnormalities Including Glossalgia -Clinical Characteristics of Glossodynia-

舌痛などの舌症状を主訴とする患者の臨床統計学的検討—舌痛症の特異性についてー.

Purpose: There are many kinds of diseases that can cause glossalgia, and it is not always easy to determine the differential diagnosis. Therefore, establishment of screening procedures for organic factors of glossalgia is important to obtain the correct diagnosis. We statistically analyzed the findings in patients with various lingual abnormalities. Methods: Patients were 104 persons consisted of 12 males and 92 females. Medical history taking, intraoral and extraoral examinarion, panoramic x-ray radiography, blood examination, culture, and salivation test were performed. It was also determined whether local analgesic or nonsteroidal anti-inflammatory drug relieved the pain or not. Results: Glossalgia-related diseases consisted of oral candidiasis, xerostomia, glossitis, glossodynia and other diseases. The major part of oral candidiasis lacked a change in organic appearance. Concerning xerostomia, a sense of thirst was also lacking. Local analgesic or nonsteroidal anti-inflammatory drug showed a limited effect on glossodynia. The prevalence of taste disorder or hypozincemia in glossodynia was less than that in other diseases. On the other hand the prevalence of palm sweating in glossodynia was greater than that in other diseases. Conclusions: Culture and salivation test were necessary for the diagnosis of either oral candidiasis without a change in organic appearance or xerostomia without a sense of thirst. If these examinations were not performed, these cases might be diagnosed as glossodynia. The presence of pain on tongue tip and the absence of food-induced pain or oppressive pain were specific findings of glossodynia. Lingual mucous damage could not be directly correlated with pathology of glossodynia judging from the nature of glossalgia and the result of analgesic effects. Taste disorder and hypozincemia were found to be nonspecific findings of glossodynia. It was suggested that glossodynia is related to dysautonomia, and palm sweating is a specific finding of glossodynia.

目的:舌痛の器質的要因をスクリーニングする系統的診断システムを提案し，本法によって診断された舌痛関連疾患を検討する．方法:2007年1月から2009年12月までに舌痛などの舌症状を主訴としてで徳島大学病院歯科口腔外科を受診した患者104名(男性12名，女性92名，平均68歳2か月)を臨床統計学的に検討した．病歴聴取，口腔内・外診査，パノラマエックス線検査，血液検査，培養検査および唾液分泌検査を行った．局所麻酔薬と非ステロイド性抗炎症薬の効果も確認した．結果:原因疾患は口腔カンジダ症，口腔乾燥症，舌炎，舌痛症などであった．器質的変化や自覚症状の乏しい口腔カンジダ症や口腔乾燥症が認められた．舌痛症の多くは舌尖に発現し，食餌性刺激による誘発痛や圧痛が認められないものが多く，局所麻酔薬や非ステロイド系抗炎症薬の効果も乏しかった．舌痛症における味覚異常や低亜鉛血症の発現頻度は低く，手掌部発汗が高頻度に認められた．結論:培養検査や唾液分泌検査が不可欠であり，器質的変化や自覚症状の乏しい口腔カンジダ症や口腔乾燥症は舌痛症と診断される可能性があった．舌尖部疼痛を有し，食餌性刺激による誘発痛や圧痛がないことが舌痛症特異的な所見と考えられ，その病態に舌粘膜障害の関与は否定的であった．味覚障害や低亜鉛血症は舌痛症特異的な所見ではなかった．手掌部発汗は舌痛症特異的な所見と考えられ，その病態に自律神経異常の関与が示唆された．


Rapidly-Enlarged and Ruptured Submucous Hematoma of Soft and Hard Palate during Anticoagulation Therapy with Warfarin : A Case Report

ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例

We present a case of rapidly-enlarged and ruptured submucous hematoma of soft and hard palate during warfarin therapy.
The Patient was a 76-year old man. He suddenly had palatal swelling and difficulty in breathing while eating, and was brought to us by ambulance. He has been receiving warfarin therapy and treatments for paroxysmal atrial fibrillation, diabetes mellitus and high blood pressure. On blood examination normocytic anemia was diagnosed. Blood coagulation test demonstrated an elevated value (1.52) of PT-INR. The mucous membrane was exfoliated from both soft and hard palate without abnormalities in either respiratory or circulatory status. Immediately, suturing of the mucosa to the submucosal tissue was performed along with astriction.
Emphasis should be on soft and hard palatine submucous hematoma as an oral bleeding complication associated with warfarin therapy.

ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例を経験した．
症例は76歳，男性．食事中，急に口蓋が腫脹し，呼吸困難を訴え救急搬送された．発作性心房細動，糖尿病，高血圧症でワルファリン療法中であった．正球性貧血とPT-INR値は1.52を呈した．呼吸・循環動態に異常なく，軟硬口蓋粘膜が広範に剥離していたが，圧迫止血後，粘膜弁を縫合閉鎖した．
症例は留意すべき口腔の出血性合併症であった．

Journal of Japanese Society of Oral Medicine


副オトガイ孔を走行する神経様組織の捻除により口唇感覚異常が改善した症候性三叉神経痛の1例-神経学的検査の有用性について-


真菌培養検査におけるカンジダの検出に影響する臨床的要因の検討ー口腔乾燥の関連についてー


重症心身障害児者における口腔ケアシステムの確立に向けて J.Eilersの口腔アセスメントと口腔ケアプロトコールの有効性の検証

日本看護学会論文集: 看護総合

日本看護学会論文集: 看護総合


降下性壊死性縦隔炎を発症した下顎智歯周囲炎の1例

降下性壊死性縦隔炎を発症した下顎智歯周囲炎の1例

We present a case of pericoronitis of lower wisdom tooth leading to descending necrotizing mediastinitis. A 52-year-old man visited our hospital because of swelling and pain in buccal region on the right side in spite of chemotherapeutics at a practicing physician, whose diabetic nephropathy had been treated with dialysis treatment by the same physician. Orthopantomography elucidated an impacted wisdom tooth of the right side mandible and osteosclerosis around there. CT revealed inflammatory thickening of subcutaneous fat tissue from buccal to cervical region. In the blood examination, the values of WBCs, RBCs, platelets, CRP, AST, LDH, TG, BUN, creatinine, GLU, K and Ca increased abnormally, while those of hemoglobin, MCV，MCH，MCHC, albumin, Cl, decreased extraordinarily. Immediate medication of antibiotics was worked out under a clinical diagnosis of pericoronitis of lower wisdom tooth, periostitis of the mandible and cervical cellulitis. Nevertheless, rapid inflamation progressed downward; mediastinal abscess was found by CT image taken 6 days later from the beginning of the therapy. Immediately, extraction of pathogenic teeth, cervical drainage, and transcervical and transthoracic mediastinal drainage were performed under a diagnosis of descending necrotizing mediastinitis. Moreover, bacterial examination was performed using a pus specimen derived from abscess; α-Streptococcus and Prevotella intermedia were detected. CT taken 2 weeks later from the beginning of the therapy revealed continuing bilateral pleural and pericardial effusion in spite of intensive care. Unfortunately he was died of multi organ failure caused by septic shock a month later from the beginning of the therapy.


抜歯後出血を契機に診断された高齢者における先天性血友病Aの1例

抜歯後出血を契機に診断された高齢者における先天性血友病Aの1例


著しい骨吸収を伴う歯性上顎洞炎の1例

著しい骨吸収を伴う歯性上顎洞炎の1例


共鳴振動周波数分析装置を用いた即時荷重インプラント安定性の経時的評価

共鳴振動周波数分析装置を用いた即時荷重インプラント安定性の経時的評価

日本顎顔面インプラント学会誌

日本顎顔面インプラント学会誌


舌背部に発生した孤立性神経線維腫の1例

舌背部に発生した孤立性神経線維腫の1例

Japanese Journal of Oral & Maxillofacial Surgery


セルフドリリングタイプ顎間固定用スクリューの有用性に関する検討

セルフドリリングタイプ顎間固定用スクリューの有用性に関する検討

Japanese Society of Oral and Maxillofacial Traumatology


Histological evaluation of apatite cement containing atelocollagen

Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC.


HAP-PLGA複合体による顎骨再生への応用に関する実験的研究

HAP-PLGA複合体による顎骨再生への応用に関する実験的研究


矯正牽引装置により治療を行った小児外傷性歯牙陥入の1例

矯正牽引装置により治療を行った小児外傷性歯牙陥入の1例


Intermaxillary Fixation using Alveolar Bone Screws in Mandiblar Fractures --- Report of Five Cases

下顎骨骨折非観血的整復固定症例における顎間固定用スクリューの応用 --- 5症例の検討

日本口腔顎顔面外傷学会誌


Proliferation and Differentiation of Cultured MC3T3-E1 Osteoblasts on Surface-layer Modified Hydroxyapatite Ceramic with Acid and Heat Treatments

Effects of functionally gradient calcium phosphate consisting of hydroxyapatite (HAP) and alpha-tricalcium phosphate (alpha-TCP) on proliferation and differentiation of osteoblasts were evaluated using MC3T3-E1 cells. There were no significant differences in the proliferation of MC3T3-E1 cells among HAP-alpha-TCP functionally gradient calcium phosphate, pure HAP, and cell culture plastic wells. mRNA expressions of type I collagen, alkaline phosphate, and osteocalcine were evaluated as indexes of initial; mid-stage, and late-stage osteoblastic differentiation. Basically, HAP-alpha-TCP functionally gradient calcium phosphate and pure HAP enhanced the expressions of the three markers when compared with that of cell culture plastic wells. For type I collagen and alkaline phosphate expressions, HAP-alpha-TCP functionally gradient calcium phosphate showed the same expression level as pure HAP. For osteocalcine expression, HAP-alpha-TCP functionally gradient calcium phosphate showed a higher level than pure HAP. We concluded, therefore, HAP-alpha-TCP functionally gradient calcium phosphate has good potential to be a bone filler material with high osteoconductivity.


Prediction of Tsunami and Related Damage to Dental Clinics Caused by the Nankai Trough Earthquake in the Tokushima Prefecture

徳島県における南海トラフ大地震発生後の歯科医院浸水被害等の予測

人と地域共創センター紀要

人と地域共創センター紀要


徳島大学病院口腔内科-発足前後5年間における外来・入院患者の臨床統計的観察-

徳島大学病院口腔内科-発足前後5年間における外来・入院患者の臨床統計的観察-