type: misc

label: url

en: プロバイオティクスによる新しい健康長寿戦略 脳腸相関を介した睡眠改善作用

ja: プロバイオティクスによる新しい健康長寿戦略 脳腸相関を介した睡眠改善作用

en: The Japanese Journal of Stress Science

ja: ストレス科学


en: RNA Binding Proteins and Genome Integrity.

en: Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites have been shown to be direct players in the prevention or repair of DNA damage. In addition, non-coding RNAs, themselves, are involved in the RNA-mediated DNA repair system. Furthermore, RNA modification such as m6A methylation might also contribute to the ultraviolet-responsive DNA damage response. Accumulating evidence suggests that RNA metabolism is more deeply involved in diverse cellular functions than previously expected, and is also intricately associated with the maintenance of genome integrity. In this review, we highlight the roles of RBPs in the maintenance of genome integrity.

en: International Journal of Molecular Sciences


en: 腸に定着してストレスを緩和する乳酸菌

ja: 腸に定着してストレスを緩和する乳酸菌

en: FOOD STYLE

ja: FOOD STYLE


en: エピジェネティクス・NMD

ja: エピジェネティクス・NMD

en: Journal of Gastrointestinal Research

ja: Journal of Gastrointestinal Research


en: 末梢血の遺伝子発現解析によるストレス評価

ja: 末梢血の遺伝子発現解析によるストレス評価

en: ストレス科学


en: ストレスとエピジェネテイクス

ja: ストレスとエピジェネテイクス

en: 産業精神保健

ja: 産業精神保健


en: ストレスバイオマーカーの同定と今後の 展開

ja: ストレスバイオマーカーの同定と今後の 展開

en: Surgery Frontier

ja: Surgery Frontier


en: ASDに特徴的な末梢血白血球の遺伝子発現

ja: ASDに特徴的な末梢血白血球の遺伝子発現

en: 精神経誌

ja: 精神経誌


en: Mechanisms and consequences of alternative polyadenylation.

en: Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is altered, influencing the fate of mRNAs in several ways, for example, by altering the availability of RNA binding protein sites and microRNA binding sites. The mechanisms governing both global and gene-specific APA are only starting to be deciphered. Here we review what is known about these mechanisms and the functional consequences of alternative polyadenylation.

en: Molecular Cell

ja: Molecular Cell