toshinishi/published_papers/52710257 松下 知樹 新家 崇義 平岡 淳一郎 廣島 由夏 Badrakhzul Zayabat Badarchin Manduukhai 高尾 正一郎 原田 雅史 岩本 誠司 西庄 俊彦 西良 浩一 坂東 良美 上原 久典 新たな手法であるMRIテクスチャ解析によって神経原性腫瘍を鑑別する 徳島医学会 四国医学雑誌 2758-3279 81 1-2 83 84 20250600 toshinishi/published_papers/52711929 Tomoki Matsushita Takayoshi Shinya Toshihiko Nishisho Koichi Sairyo Yoshimi Bando Hisanori Uehara Masafumi Harada The Diagnostic Ability of Texture Analysis in MR Imaging for Neurogenic Tumors. OBJECTIVES: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms requiring differentiation from benign neurogenic tumors on diagnostic imaging. We evaluated the diagnostic utility of texture analysis (TA) in distinguishing seven pathologically confirmed MPNSTs from eight schwannomas using magnetic resonance imaging (MRI), including T1- (T1WI) and T2-weighted imaging (T2WI), and apparent diffusion coefficient (ADC) maps. TA's performance was compared with that of conventional approaches using ADC values alone. METHODS: Tumors were segmented, and 90 texture features were extracted using LIFEx software. Significantly different features (p < 0.05) were identified using the Mann-Whitney U test and evaluated through receiver operating characteristic (ROC) analysis. ADC maps were used to measure the minimum, mean, and maximum ADC values, followed by ROC analysis. RESULTS: Two T2WI-based texture features (neighborhood grey-tone difference matrix Contrast and grey-level size zone matrix Grey Level Variance) demonstrated the highest diagnostic performance (area under the curve = 0.911 [95% confidence interval (CI):0.755-1.000]), comparable to the minimum and mean ADC values (area under the curve = 0.898 [95% CI:0.691-1.000]). CONCLUSIONS: TA may help differentiate MPNSTs from schwannomas. T2WI-based TA offers a viable alternative when ADC maps are limited by magnetic susceptibility artifacts. J. Med. Invest. 72 : 367-374, August, 2025. The journal of medical investigation : JMI 72 3.4 367 374 20250000 10.2152/jmi.72.367 41183939 toshinishi/published_papers/52711963 炭素11標識メチオニンPET/CTによる筋骨格系病変の臨床診断(Dynamic carbon-11-labeled methionine PET/CT for the clinical diagnosis of musculoskeletal lesions) (公社)日本医学放射線学会 日本医学放射線学会秋季臨床大会抄録集 1347-7951 60 S458 S459 20240900 toshinishi/published_papers/42311492 Makoto Takeuchi Toshihiko Nishisho Shunichi Toki Shinji Kawaguchi Shunsuke Tamaki Takeshi Oya Yoshihiro Uto Toyomasa Katagiri Koichi Sairyo Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondrial dysfunction in synovial sarcoma. BACKGROUND: Synovial sarcoma (SS) has limited treatment options and there is an urgent need to develop a novel therapeutic strategy to treat SS. Blue light (BL) has been shown to inhibit the growth of several cancer cells. However, the efficacy of BL in soft tissue sarcomas such as SS has not been demonstrated, and the detailed mechanism underlying the antitumor activity of BL is not fully understood. In this study, we investigated the antitumor effect of BL on SS. METHODS: Human SS cell lines were continuously irradiated with BL using light-emitting diodes (LEDs) in an incubator for in vitro analysis. The chicken chorioallantoic membrane (CAM) tumors and xenograft tumors in mice were subjected to daily BL irradiation with LEDs. RESULTS: BL caused growth inhibition of SS cells and histological changes in CAM tumors. BL also suppressed the migration and invasion abilities of SS cells. The type of cell death in SS cells was revealed to be apoptosis. Furthermore, BL induced excessive production of reactive oxygen species (ROS) in mitochondria, resulting in oxidative stress and malfunctioned mitochondria. Reducing the production of ROS using N-acetylcysteine (NAC), a ROS scavenger, attenuated the inhibitory effect of BL on SS cells and mitochondrial dysfunction. In addition, BL induced autophagy, which was suppressed by the administration of NAC. The autophagy inhibitor of 3-methyladenine and small interfering RNA against the autophagy marker light chain 3B facilitated apoptotic cell death. Moreover, BL suppressed tumor growth in a mouse xenograft model. CONCLUSION: Taken together, our results revealed that BL induced apoptosis via the ROS-mitochondrial signaling pathway, and autophagy was activated in response to the production of ROS, which protected SS cells from apoptosis. Therefore, BL is a promising candidate for the development of an antitumor therapeutic strategy targeting SS. Cancer medicine 12 8 9668 9683 20230400 10.1002/cam4.5664 36722116 toshinishi/published_papers/52712005 岡田 直子 新家 崇義 松下 知樹 音見 暢一 高尾 正一郎 手束 文威 土岐 俊一 西庄 俊彦 西良 浩一 坂東 良美 上原 久典 原田 雅史 軟部肉腫との鑑別に苦慮した傍椎体部myoepithelial carcinomaの一例 (公社)日本医学放射線学会 日本医学放射線学会秋季臨床大会抄録集 1347-7951 57 S411 S411 20210800 toshinishi/published_papers/47109304 Yasuyuki Omichi Toshihiko Nishisho Kazuya Yamashita Haruhiko Yoshinari Hirofumi Kosaka Shinsuke Katoh Shunichi Toki Toru Maeda Koichi Sairyo Extradural ancient schwannoma of the spine: 2 cases and literature review Elsevier B.V. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 2214-7519 23 null null 20210301 10.1016/j.inat.2020.101016 2-s2.0-85097403008 toshinishi/published_papers/32469054 Shunichi Toki Miyuki Sone Akihiko Yoshida Toshihiko Nishisho Tabu Gokita Eisuke Kobayashi Fumihiko Nakatani Hirokazu Chuman Shunsuke Sugawara Yasuaki Arai Akira Kawai Image-guided core needle biopsy for musculoskeletal lesions. BACKGROUND: Image-guided percutaneous core needle biopsy (CNB) has been an important diagnostic procedure for musculoskeletal lesions. Here we surveyed the variety of diagnostic strategies available and assessed the clinical usefulness and limitations of image-guided CNB carried out by a multidisciplinary team comprising specialists in various fields. METHODS: We conducted a retrospective study of 284 image-guided CNBs among 1899 consecutive biopsy procedures carried out at our institution for musculoskeletal tumorous conditions, focusing on their effectiveness including diagnostic accuracy and utility for classification of specimens according to malignant potential and histological subtype as well as their correlation with biopsy routes. RESULTS: Among the 284 studied biopsies, 252 (88.7%) were considered clinically "effective". The sensitivity for detection of malignancy was 94.0% (110/117) and the specificity was 95.3% (41/43). The diagnostic accuracy for detection of malignancy was 94.4% (151/160) and that for histological subtype was 92.3% (48/52). The clinical effectiveness of the procedure was correlated with the complexity of the biopsy route (P = 0.015); the trans-pedicular, trans-retroperitoneal and trans-sciatic foramen approaches tended to yield ineffective results. Repeat biopsy did not have a significant impact on the effectiveness of image-guided CNB (P = 0.536). CONCLUSIONS: The diagnostic accuracy rates of image-guided CNB performed at multidisciplinary sarcoma units were usable even for patients who have variety of diagnostic biopsy procedures. It is important to establish and implement diagnostic strategies based on an understanding that complicated routes, especially for spine and pelvic lesions, may be associated with ineffectiveness and/or complications. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association null null 20210130 10.1016/j.jos.2020.12.017 33531215 toshinishi/published_papers/32469055 Shusuke Yagi Robert Zheng Seiichi Nishiyama Yutaka Kawabata Takayuki Ise Kosuke Sugiura Haruhiko Yoshinari Toshihiko Nishisho Yoshimi Bando Kumiko Kagawa Daiju Fukuda Tomohiro Soga Yoshihito Saijo Kenya Kusunose Koji Yamaguchi Hirotsugu Yamada Takeshi Soeki Tetsuzo Wakatsuki Shinji Kawahito Masashi Akaike Masataka Sata Osteolytic primary bone lymphoma in the multiple bones. Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019. The journal of medical investigation : JMI 66 3.4 347 350 20190000 10.2152/jmi.66.347 31656303 toshinishi/published_papers/47132660 Ichiro Tonogai Yuhei Yamasaki Toshihiko Nishisho Koichi Sairyo Mucous Cyst at the Interphalangeal Joint of the First Toe Caused by Contact Pressure With the Second Toe due to Hallux Valgus: A Case Report SAGE Publications Inc. Foot and Ankle Orthopaedics 2473-0114 3 3 null null 20180000 10.1177/2473011418775101 2-s2.0-85117725106 toshinishi/published_papers/32469056 Ryo Miyagi Toshihiko Nishisho Shinjiro Takata Yoshimitsu Shimatani Shunichi Toki Koichi Sairyo Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. BACKGROUND: Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD. CASE PRESENTATION: A 73-year-old woman with a diagnosis of limb-girdle MD visited our department for recurrence of a huge tumor in her left thigh. She had undergone resection of a lipoma at the same site more than 20 years earlier. Imaging studies revealed a lipomatous tumor in her left thigh. We performed marginal resection including the adjacent muscles. Histological diagnosis was atypical lipomatous tumor. The postoperative course was uneventful, with no recurrence at 36 months of follow-up. CONCLUSION: We encountered a huge atypical tumor in a patient with MD. This is the first detailed report to describe an association between ALT and MD. We hypothesize that degenerative changes occurring in adipose tissue during muscle atrophy can cause lipomatous neoplasms and moreover that the mutation of MD-related genes may lead to the proliferation of tumor cells or to malignancy. Case reports in orthopedics 2017 3025084 3025084 20170000 10.1155/2017/3025084 28634560 toshinishi/published_papers/34172839 新家 崇義 音見 暢一 西庄 俊彦 苛原 早保 久保 典子 西良 浩一 原田 雅史 骨軟部腫瘍におけるDynamic F-18 FDG PET/CTとC-11メチオニンPET/CTの前方視的検討 (公社)日本医学放射線学会 日本医学放射線学会秋季臨床大会抄録集 1347-7951 52 S504 S504 20160800 toshinishi/published_papers/35208816 NISHISHO Toshihiko 西庄 俊彦 高橋 光彦 玉置 康晃 安井 夏生 A case of extraskeletal myxoid chondrosarcoma of popliteal fossa treated with the bilobed flap based on the superior lateral genicular artery 膝窩部に発生した骨外性粘液型軟骨肉腫に対して区域皮弁で再建を行った1 例 THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY The Central Japan Journal of Orthopaedic Surgery & Traumatology 中部日本整形外科災害外科学会雑誌 0008-9443 56 6 1415 1416 20130000 10.11359/chubu.2013.1415 toshinishi/published_papers/32469059 Yoshihiro Morita Kenji Hata Masako Nakanishi Toshihiko Nishisho Yoshiaki Yura Toshiyuki Yoneda Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism underlying OSCC metastasis to regional lymph nodes, the highly metastatic fluorescent labeled OSCC cell line SAS-LM3 was successfully established allowing us to monitor the progression of lymph node metastases in a non-invasive manner. SAS-LM3 tumors showed increased lymphangiogenesis and elevated expression of VEGF-C, a potent stimulator of lymphangiogenesis, compared to parental SAS tumors. SAS-LM3 showed high expression of cyclooxygenase-2 (COX-2) compared to parental SAS cells and immunohistochemical analysis demonstrated intense COX-2 expression at the primary site. Inactivation of COX-2 by knockdown or the COX-2 inhibitor NS-398 decreased VEGF-C expression. Administration of COX-2 inhibitor NS-398 in SAS-LM3 tumor-bearing mice suppressed tumor lymphangiogenesis and lymphatic metastases. Collectively, our results indicate that COX-2 promotes tumor lymphangiogenesis and lymph node metastasis of OSCC. COX-2 ablation holds promise as a potential therapeutic approach for lymph node metastasis in OSCC. International journal of oncology 41 3 885 92 20120900 10.3892/ijo.2012.1529 22735610 toshinishi/published_papers/32469060 Toshihiko Nishisho Naoyoshi Hanaoka Kenji Endo Mitsuhiko Takahashi Natsuo Yasui Locally administered zoledronic Acid therapy for giant cell tumor of bone. Giant cell tumor of bone is locally aggressive and occurs in the meta-epiphyseal region of long bones. Because of its high recurrence rate, local adjuvant therapies such as phenol or liquid nitrogen have been recommended. In the present study, zoledronic acid, a nitrogen-containing bisphosphonate, was administered locally as an adjuvant during a biopsy. An otherwise healthy 43-year-old man presented with pain and swelling in the right knee. Plain radiographs showed an osteolytic lesion of the right proximal tibia. An open biopsy was performed and the intraoperative pathologic diagnosis was giant cell tumor of bone. Following biopsy, the defect was filled with betatricalcium phosphate, and 4 mg of zoledronic acid was locally administered into the tumor lesion. Two months after the biopsy, curettage and bone grafting were performed. Sections were obtained during the curettage for histology to evaluate the response to bisphosphonate treatment. Histologic examination revealed massive tumor cell death in the lesion in which both stromal cells and osteoclast-like giant cells were necrotic. Curettage was performed and the defect was filled with a commercial preshaped hydroxyapatitetricalcium phosphate bone substitute. Eighteen months after curettage, the patient had regained full range of motion and good function of the knee, and radiographs at 18 months after curettage revealed no recurrence of giant cell tumor of bone. Orthopedics 34 7 e312-5 null 20110707 10.3928/01477447-20110526-22 21717996 toshinishi/published_papers/32469061 Toshihiko Nishisho Kenji Hata Masako Nakanishi Yoshihiro Morita Ge-Hong Sun-Wada Yoh Wada Natsuo Yasui Toshiyuki Yoneda The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Accumulating evidence indicates that the acidic microenvironments critically influence malignant behaviors of cancer including invasiveness, metastasis, and chemoresistance. Because the vacuolar-type H(+)-ATPase (V-ATPase) has been shown to cause extracellular acidification by pumping protons, we studied the role of V-ATPase in distant metastasis. Real-time PCR analysis revealed that the high-metastatic B16-F10 melanoma cells strongly expressed the a3 isoform V-ATPase compared to the low-metastatic B16 parental cells. Consistent with this, B16-F10 cells created acidic environments in lung metastases by acridine orange staining and strong a3 V-ATPase expression in bone metastases by immunohistochemistry. Immunocytochemical analysis showed B16-F10 cells expressed a3 V-ATPase not only in cytoplasm but also plasma membrane, whereas B16 parental cells exhibited its expression only in cytoplasm. Of note, knockdown of a3 V-ATPase suppressed invasiveness and migration with reduced MMP-2 and MMP-9 expression in B16-F10 cells and significantly decreased lung and bone metastases, despite that tumor growth was not altered. Importantly, administration of a specific V-ATPase a3 inhibitor FR167356 reduced bone metastasis of B16-F10 cells. These results suggest that a3 V-ATPase promotes distant metastasis of B16-F10 cells by creating acidic environments via proton secretion. Our results also suggest that inhibition of the development of cancer-associated acidic environments by suppressing a3 V-ATPase could be a novel therapeutic approach for the treatment of cancer metastasis. Molecular cancer research : MCR 9 7 845 55 20110700 10.1158/1541-7786.MCR-10-0449 21669964 toshinishi/published_papers/32469062 Naoyoshi Hanaoka Tomohiro Goto Tokio Kasai Tetsuya Matsuura Toshihiko Nishisho Tetsuya Enishi Natsuo Yasui Extraskeletal Ewing's sarcoma in a 67-year-old man. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 16 2 250 2 20110300 10.1007/s00776-011-0024-8 21327980 toshinishi/published_papers/32469063 Toshiyuki Yoneda Kenji Hata Masako Nakanishi Maho Nagae Tomotaka Nagayama Hiroki Wakabayashi Toshihiko Nishisho Teruhisa Sakurai Toru Hiraga Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain. Bone pain is one of the most common complications in cancer patients with bone metastases. Although the mechanism of cancer-associated bone pain is poorly understood, clinical observations that inhibitors of osteoclasts such as bisphosphonates (BPs) efficiently reduce bone pain suggest a potential role of osteoclasts, which play a central role in the development and progression of bone metastasis. Osteoclasts dissolve bone minerals by releasing protons through the a3 isoform of the vacuolar-H(+)-ATPase, creating acidic microenvironments. In addition, cancer cells, inflammatory cells and immune cells that reside in bone metastases also produce acidic conditions by releasing protons. It has been well-known that acidic conditions due to proton release cause pain. Our study showed that the sensory nociceptive neurons innervate bone and these neurons express acid-sensing nociceptors such as the acid-sensing ion channels and transient receptor potential channel-vanilloid subfamily members. Acid signals received by these nociceptors subsequently activate intracellular signaling pathways and transcription factors in sensory neurons. The understanding of the nociceptive events following proton release and subsequent creation of acidic microenvironments leads us to design novel molecular-based approaches for reducing bone pain associated with cancer and inflammation. Bone 48 1 100 5 20110100 10.1016/j.bone.2010.07.009 20637323 toshinishi/published_papers/32469064 Masako Nakanishi Kenji Hata Tomotaka Nagayama Teruhisa Sakurai Toshihiko Nishisho Hiroki Wakabayashi Toru Hiraga Shigeyuki Ebisu Toshiyuki Yoneda Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain. Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated in inflammatory pain. The inflammatory site is acidic due to proton release from infiltrating inflammatory cells. Acid activation of peripheral nociceptors relays pain signals to the CNS. Here, we examined whether acid activated the transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression. Chemically induced inflammation was associated with thermal hyperalgesia and increased CGRP expression in dorsal root ganglion (DRG) in rats. In organ cultures of DRG, acid (pH 5.5) elevated CGRP expression and the selective Trpv1 antagonist 5'-Iodoresiniferatoxin decreased it. Trpv1-deficient DRG showed reduced CGRP increase by acid. Of note, many of CGRP/Trpv1-positive DRG neurons exhibited the phosphorylation of cAMP response element-binding protein (CREB), a nociceptive transcription factor. Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression. Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity. These effects were inhibited by a Ca(2+)/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93. In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain. Molecular biology of the cell 21 15 2568 77 20100801 10.1091/mbc.E10-01-0049 20534813 toshinishi/published_papers/34226825 油形 公則 西庄 俊彦 松浦 哲也 安井 夏生 松井 好人 骨延長術における骨格筋のVEGF発現と筋肉内血管新生および筋再生との関係 日本創外固定・骨延長学会 日本創外固定・骨延長学会雑誌 1342-3495 20 179 179 20090200 toshinishi/published_papers/32469079 Shunji Nakano Toshihiko Nishisyo Daisuke Hamada Hirofumi Kosaka Kiminori Yukata Koichi Oba Yoshiteru Kawasaki Hideaki Miyoshi Hiroshi Egawa Isamu Kinoshita Natsuo Yasui Treatment of dysplastic osteoarthritis with labral tear by Chiari pelvic osteotomy: outcomes after more than 10 years follow-up. INTRODUCTION: The presence of a damaged labrum is one of many factors influencing the outcomes of Chiari pelvic osteotomy. However, there are few previous papers describing the long-term outcomes of Chiari pelvic osteotomy with labrectomy. The purpose of this study was to evaluate the long-term clinical and radiological outcomes of Chiari pelvic osteotomy for dysplastic hips with labral tears. We compared outcomes between labrectomy (+) and labrectomy (-) groups. PATIENTS AND METHODS: Chiari pelvic osteotomies were performed by one surgeon on 34 dysplastic hips with labral tears between 1983 and 1996, in which labrectomy was performed on 23 hips but not on 11 hips. Three patients undergoing labrectomy were lost to follow-up evaluation within 5 years after surgery. The average age of the remaining 31 patients was 35.5 years (range, 16-54 years). The clinical and radiographic surveillance averaged 16.0 years (range, 10-23.3 years). RESULTS: In all patients, pain disappeared after the operation. At the end of the study, 8 of the 31 patients displayed clinical deterioration. Progression of osteoarthritis (OA) was observed in 11 hips. Patients with poor results have not opted for revision surgery except for one patient. In the labrectomy (+) group, 10 of the 20 hips showed progression of OA and the clinical outcomes of 6 patients deteriorated. In the labrectomy (-) group, 1 of the 11 hips showed progression of OA and 2 patients deteriorated clinically. Radiological outcomes differed significantly between the two groups. CONCLUSION: Labrectomy accompanying Chiari pelvic osteotomy is an acceptable procedure for relieving pain caused by the damaged labrum, but the outcomes have a tendency to deteriorate after 10 or more years postoperatively. Archives of orthopaedic and trauma surgery 0936-8051 128 1 103 9 20080100 17943297 toshinishi/published_papers/34226854 油形 公則 西庄 俊彦 松井 好人 松浦 哲也 高田 信二郎 安井 夏生 骨延長術における筋肉内の血管新生と筋再生 (公社)日本整形外科学会 日本整形外科学会雑誌 0021-5325 81 8 S977 S977 20070800 toshinishi/misc/37865623 竹内 誠 後東 知宏 油形 公則 鈴江 直人 西庄 俊彦 西良 浩一 第一胸肋関節偽関節の治療経験 (一社)中部日本整形外科災害外科学会 中部日本整形外科災害外科学会雑誌 1349-0885 57 183 183 20140300 toshinishi/misc/37865624 油形 公則 高砂 智哉 西庄 俊彦 江川 洋史 後東 知宏 安井 夏生 肩関節唇骨化の1例 (一社)日本肩関節学会 肩関節 1881-6363 37 1 214 214 20120900 toshinishi/misc/52322247 西庄俊彦 波多賢二 中西雅子 森田祥弘 米田俊之 安井夏生 プロトンポンプV型ATPase a3はマウスB16悪性黒色腫細胞の遠隔転移を促進させる 日本整形外科学会雑誌 0021-5325 86 8 null null 20120000 toshinishi/misc/52322242 波多賢二 森田祥弘 森田祥弘 中西雅子 西庄俊彦 虫明仁 由良義明 米田俊之 NEDD9は乳がん細胞の上皮間葉転換を促進する 癌と骨病変研究会抄録集 14th null null 20110000 toshinishi/misc/52322278 西庄俊彦 波多賢二 中西雅子 王麗楊 森田祥弘 安井夏生 米田俊之 V-ATPase a3により形成される酸性環境は転移に重要な役割を果たす 日本整形外科学会雑誌 0021-5325 84 8 null null 20100000 toshinishi/misc/52322270 森田祥弘 森田祥弘 波多賢二 中西雅子 西庄俊彦 由良義明 米田俊之 新規TGF-β標的遺伝子NEDD9は乳がんの骨転移を制御する 癌と骨病変研究会抄録集 13th null null 20100000 toshinishi/misc/52322257 森田祥弘 森田祥弘 波多賢二 中西雅子 西庄俊彦 由良義明 米田俊之 TGF-β標的遺伝子NEDD9は新規の乳がん骨転移制御分子である 日本骨代謝学会学術集会プログラム抄録集 1349-0761 28th null null 20100000 toshinishi/misc/52322283 西庄俊彦 波多賢二 中西雅子 王麗楊 森田祥弘 安井夏生 米田俊之 がんの骨転移におけるプロトンポンプV-ATPaseサブユニットa3の役割 日本骨代謝学会学術集会プログラム抄録集 1349-0761 27th null null 20090000 toshinishi/misc/52322263 西庄俊彦 波多賢二 中西雅子 王麗楊 森田祥弘 安井夏生 米田俊之 がんの骨転移におけるプロトンポンプV-ATPaseサブユニットa3の役割 日本整形外科学会雑誌 0021-5325 83 8 null null 20090000 toshinishi/misc/52322253 西庄俊彦 西庄俊彦 波多賢二 中西雅子 王麗楊 森田祥弘 安井夏生 米田俊之 がんの骨転移におけるプロトンポンプV-ATPaseサブユニットa3の役割 癌と骨病変研究会抄録集 12th null null 20090000