=== Generating (published_papers) ===
=== Generating (teaching_experience) ===
=== Generating (misc) ===
=== Generating (research_projects) ===
=== Generating (committee_memberships) ===
=== Generating (awards) ===
=== Generating (association_memberships) ===
=== Generating (presentations) ===
==== begin registerFile(/WWW/pub2/data/ERD/person/244268/researchmap/published_papers-propagate.jsonl) ====
line:1, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/41183939","label":"url"},{"@id":"https://www.scopus.com/pages/publications/105020772713","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=464166","label":"url"}],"paper_title":{"en":"The Diagnostic Ability of Texture Analysis in MR Imaging for Neurogenic Tumors.","ja":"The Diagnostic Ability of Texture Analysis in MR Imaging for Neurogenic Tumors."},"authors":{"en":[{"name":"Matsushita Tomoki"},{"name":"Shinya Takayoshi"},{"name":"Nishisho Toshihiko"},{"name":"Sairyo Koichi"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Harada Masafumi"}],"ja":[{"name":"松下 知樹"},{"name":"新家 崇義"},{"name":"西庄 俊彦"},{"name":"西良 浩一"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"原田 雅史"}]},"description":{"en":"Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms requiring differentiation from benign neurogenic tumors on diagnostic imaging. We evaluated the diagnostic utility of texture analysis (TA) in distinguishing seven pathologically confirmed MPNSTs from eight schwannomas using magnetic resonance imaging (MRI), including T1- (T1WI) and T2-weighted imaging (T2WI), and apparent diffusion coefficient (ADC) maps. TA's performance was compared with that of conventional approaches using ADC values alone.Tumors were segmented, and 90 texture features were extracted using LIFEx software. Significantly different features (p < 0.05) were identified using the Mann-Whitney U test and evaluated through receiver operating characteristic (ROC) analysis. ADC maps were used to measure the minimum, mean, and maximum ADC values, followed by ROC analysis.Two T2WI-based texture features (neighborhood grey-tone difference matrix Contrast and grey-level size zone matrix Grey Level Variance) demonstrated the highest diagnostic performance (area under the curve = 0.911 [95% confidence interval (CI):0.755-1.000]), comparable to the minimum and mean ADC values (area under the curve = 0.898 [95% CI:0.691-1.000]).TA may help differentiate MPNSTs from schwannomas. T2WI-based TA offers a viable alternative when ADC maps are limited by magnetic susceptibility artifacts. J. Med. Invest. 72 : 367-374, August, 2025.","ja":"Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms requiring differentiation from benign neurogenic tumors on diagnostic imaging. We evaluated the diagnostic utility of texture analysis (TA) in distinguishing seven pathologically confirmed MPNSTs from eight schwannomas using magnetic resonance imaging (MRI), including T1- (T1WI) and T2-weighted imaging (T2WI), and apparent diffusion coefficient (ADC) maps. TA's performance was compared with that of conventional approaches using ADC values alone.Tumors were segmented, and 90 texture features were extracted using LIFEx software. Significantly different features (p < 0.05) were identified using the Mann-Whitney U test and evaluated through receiver operating characteristic (ROC) analysis. ADC maps were used to measure the minimum, mean, and maximum ADC values, followed by ROC analysis.Two T2WI-based texture features (neighborhood grey-tone difference matrix Contrast and grey-level size zone matrix Grey Level Variance) demonstrated the highest diagnostic performance (area under the curve = 0.911 [95% confidence interval (CI):0.755-1.000]), comparable to the minimum and mean ADC values (area under the curve = 0.898 [95% CI:0.691-1.000]).TA may help differentiate MPNSTs from schwannomas. T2WI-based TA offers a viable alternative when ADC maps are limited by magnetic susceptibility artifacts. J. Med. Invest. 72 : 367-374, August, 2025."},"publication_date":"2025","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"72","number":"3.4","starting_page":"367","ending_page":"374","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.72.367"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36722116","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=402151","label":"url"}],"paper_title":{"en":"Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondrial dysfunction in synovial sarcoma.","ja":"Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondrial dysfunction in synovial sarcoma."},"authors":{"en":[{"name":"Takeuchi Makoto"},{"name":"Nishisho Toshihiko"},{"name":"Toki Shun-ichi"},{"name":"Kawaguchi Shinji"},{"name":"Tamaki Shunsuke"},{"name":"Oya Takeshi"},{"name":"Uto Yoshihiro"},{"name":"Katagiri Toyomasa"},{"name":"Sairyo Koichi"}],"ja":[{"name":"竹内 誠"},{"name":"西庄 俊彦"},{"name":"土岐 俊一"},{"name":"川口 真司"},{"name":"玉置 俊輔"},{"name":"尾矢 剛志"},{"name":"宇都 義浩"},{"name":"片桐 豊雅"},{"name":"西良 浩一"}]},"description":{"en":"Taken together, our results revealed that BL induced apoptosis via the ROS-mitochondrial signaling pathway, and autophagy was activated in response to the production of ROS, which protected SS cells from apoptosis. Therefore, BL is a promising candidate for the development of an antitumor therapeutic strategy targeting SS.","ja":"Taken together, our results revealed that BL induced apoptosis via the ROS-mitochondrial signaling pathway, and autophagy was activated in response to the production of ROS, which protected SS cells from apoptosis. Therefore, BL is a promising candidate for the development of an antitumor therapeutic strategy targeting SS."},"publication_date":"2023-02-01","publication_name":{"en":"Cancer Medicine","ja":"Cancer Medicine"},"volume":"12","number":"8","starting_page":"9668","ending_page":"9683","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/cam4.5664"],"issn":["2045-7634"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2014553","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85097403008","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=421721","label":"url"}],"paper_title":{"en":"Extradural ancient schwannoma of the spine: 2 cases and literature review","ja":"Extradural ancient schwannoma of the spine: 2 cases and literature review"},"authors":{"en":[{"name":"Omichi Yasuyuki"},{"name":"Nishisho Toshihiko"},{"name":"Yamashita Kazuta"},{"name":"Yoshinari Haruhiko"},{"name":"Kosaka Hirofumi"},{"name":"Katoh Shinsuke"},{"name":"Toki Shun-ichi"},{"name":"Maeda Toru"},{"name":"Sairyo Koichi"}],"ja":[{"name":"Omichi Yasuyuki"},{"name":"西庄 俊彦"},{"name":"山下 一太"},{"name":"Yoshinari Haruhiko"},{"name":"小坂 浩史"},{"name":"加藤 真介"},{"name":"土岐 俊一"},{"name":"前田 徹"},{"name":"西良 浩一"}]},"publication_date":"2021-03-01","publication_name":{"en":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","ja":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management"},"volume":"23","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.inat.2020.101016"],"issn":["2214-7519"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33531215","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85100103585","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=421732","label":"url"}],"paper_title":{"en":"Image-guided core needle biopsy for musculoskeletal lesions","ja":"Image-guided core needle biopsy for musculoskeletal lesions"},"authors":{"en":[{"name":"Toki Shun-ichi"},{"name":"Sone Miyuki"},{"name":"Yoshida Akihiko"},{"name":"Nishisho Toshihiko"},{"name":"Gokita Tabu"},{"name":"Kobayashi Eisuke"},{"name":"Nakatani Fumihiko"},{"name":"Chuman Hirokazu"},{"name":"Sugawara Shunsuke"},{"name":"Arai Yasuaki"},{"name":"Kawai Akira"}],"ja":[{"name":"土岐 俊一"},{"name":"Sone Miyuki"},{"name":"Yoshida Akihiko"},{"name":"西庄 俊彦"},{"name":"Gokita Tabu"},{"name":"Kobayashi Eisuke"},{"name":"Nakatani Fumihiko"},{"name":"Chuman Hirokazu"},{"name":"Sugawara Shunsuke"},{"name":"Arai Yasuaki"},{"name":"Kawai Akira"}]},"description":{"en":"Image-guided percutaneous core needle biopsy (CNB) has been an important diagnostic procedure for musculoskeletal lesions. Here we surveyed the variety of diagnostic strategies available and assessed the clinical usefulness and limitations of image-guided CNB carried out by a multidisciplinary team comprising specialists in various fields. We conducted a retrospective study of 284 image-guided CNBs among 1899 consecutive biopsy procedures carried out at our institution for musculoskeletal tumorous conditions, focusing on their effectiveness including diagnostic accuracy and utility for classification of specimens according to malignant potential and histological subtype as well as their correlation with biopsy routes. Among the 284 studied biopsies, 252 (88.7%) were considered clinically \"effective\". The sensitivity for detection of malignancy was 94.0% (110/117) and the specificity was 95.3% (41/43). The diagnostic accuracy for detection of malignancy was 94.4% (151/160) and that for histological subtype was 92.3% (48/52). The clinical effectiveness of the procedure was correlated with the complexity of the biopsy route (P = 0.015); the trans-pedicular, trans-retroperitoneal and trans-sciatic foramen approaches tended to yield ineffective results. Repeat biopsy did not have a significant impact on the effectiveness of image-guided CNB (P = 0.536). The diagnostic accuracy rates of image-guided CNB performed at multidisciplinary sarcoma units were usable even for patients who have variety of diagnostic biopsy procedures. It is important to establish and implement diagnostic strategies based on an understanding that complicated routes, especially for spine and pelvic lesions, may be associated with ineffectiveness and/or complications.","ja":"Image-guided percutaneous core needle biopsy (CNB) has been an important diagnostic procedure for musculoskeletal lesions. Here we surveyed the variety of diagnostic strategies available and assessed the clinical usefulness and limitations of image-guided CNB carried out by a multidisciplinary team comprising specialists in various fields. We conducted a retrospective study of 284 image-guided CNBs among 1899 consecutive biopsy procedures carried out at our institution for musculoskeletal tumorous conditions, focusing on their effectiveness including diagnostic accuracy and utility for classification of specimens according to malignant potential and histological subtype as well as their correlation with biopsy routes. Among the 284 studied biopsies, 252 (88.7%) were considered clinically \"effective\". The sensitivity for detection of malignancy was 94.0% (110/117) and the specificity was 95.3% (41/43). The diagnostic accuracy for detection of malignancy was 94.4% (151/160) and that for histological subtype was 92.3% (48/52). The clinical effectiveness of the procedure was correlated with the complexity of the biopsy route (P = 0.015); the trans-pedicular, trans-retroperitoneal and trans-sciatic foramen approaches tended to yield ineffective results. Repeat biopsy did not have a significant impact on the effectiveness of image-guided CNB (P = 0.536). The diagnostic accuracy rates of image-guided CNB performed at multidisciplinary sarcoma units were usable even for patients who have variety of diagnostic biopsy procedures. It is important to establish and implement diagnostic strategies based on an understanding that complicated routes, especially for spine and pelvic lesions, may be associated with ineffectiveness and/or complications."},"publication_date":"2021-01-30","publication_name":{"en":"Journal of Orthopaedic Science","ja":"Journal of Orthopaedic Science"},"volume":"27","number":"2","starting_page":"448","ending_page":"455","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jos.2020.12.017"],"issn":["0949-2658"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:5, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2007138","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31656303","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85074142443","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=360965","label":"url"}],"paper_title":{"en":"Osteolytic primary bone lymphoma in the multiple bones","ja":"Osteolytic primary bone lymphoma in the multiple bones"},"authors":{"en":[{"name":"Yagi Shusuke"},{"name":"Zheng Robert"},{"name":"Nishiyama Seiichi"},{"name":"Kawabata Yutaka"},{"name":"Ise Takayuki"},{"name":"Sugiura Kosuke"},{"name":"Yoshinari Haruhiko"},{"name":"Nishisho Toshihiko"},{"name":"Bando Yoshimi"},{"name":"Kagawa Kumiko"},{"name":"Fukuda Daiju"},{"name":"Soga Tomohiro"},{"name":"Saijoh Yoshihito"},{"name":"Kusunose Kenya"},{"name":"Yamaguchi Koji"},{"name":"Yamada Hirotsugu"},{"name":"Soeki Takeshi"},{"name":"Wakatsuki Tetsuzo"},{"name":"Kawahito Shinji"},{"name":"Akaike Masashi"},{"name":"Sata Masataka"}],"ja":[{"name":"八木 秀介"},{"name":"Robert Zheng"},{"name":"Nishiyama Seiichi"},{"name":"川端 豊"},{"name":"伊勢 孝之"},{"name":"Sugiura Kosuke"},{"name":"Yoshinari Haruhiko"},{"name":"西庄 俊彦"},{"name":"Bando Yoshimi"},{"name":"Kagawa Kumiko"},{"name":"福田 大受"},{"name":"Soga Tomohiro"},{"name":"西條 良仁"},{"name":"楠瀬 賢也"},{"name":"山口 浩司"},{"name":"山田 博胤"},{"name":"添木 武"},{"name":"若槻 哲三"},{"name":"川人 伸次"},{"name":"赤池 雅史"},{"name":"佐田 政隆"}]},"description":{"en":"Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019.","ja":"Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019."},"publication_date":"2019","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"66","number":"3,4","starting_page":"347","ending_page":"350","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.66.347"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:6, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.scopus.com/pages/publications/85117725106","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=424136","label":"url"}],"paper_title":{"en":"Mucous Cyst at the Interphalangeal Joint of the First Toe Caused by Contact Pressure With the Second Toe due to Hallux Valgus: A Case Report","ja":"Mucous Cyst at the Interphalangeal Joint of the First Toe Caused by Contact Pressure With the Second Toe due to Hallux Valgus: A Case Report"},"authors":{"en":[{"name":"Tonogai Ichiro"},{"name":"Yamasaki Yuhei"},{"name":"Nishisho Toshihiko"},{"name":"Sairyo Koichi"}],"ja":[{"name":"Tonogai Ichiro"},{"name":"Yamasaki Yuhei"},{"name":"西庄 俊彦"},{"name":"Sairyo Koichi"}]},"publication_date":"2018-01-01","publication_name":{"en":"Foot & Ankle Orthopaedics","ja":"Foot & Ankle Orthopaedics"},"volume":"3","number":"3","referee":true,"identifiers":{"doi":["10.1177/2473011418775101"],"issn":["2473-0114"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:7, {"insert":{"user_id":"R000021451","type":"published_papers","id":"32451107"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23585978","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=267978","label":"url"}],"paper_title":{"en":"A massive chondroblastoma in the proximal humerus simulating malignant bone tumors","ja":"A massive chondroblastoma in the proximal humerus simulating malignant bone tumors"},"authors":{"en":[{"name":"Tonogai Ichiro"},{"name":"Takahashi Mitsuhiko"},{"name":"Manabe Hiroaki"},{"name":"Nishisho Toshihiko"},{"name":"Yasui Natsuo"}],"ja":[{"name":"殿谷 一朗"},{"name":"高橋 光彦"},{"name":"眞鍋 裕昭"},{"name":"西庄 俊彦"},{"name":"安井 夏生"}]},"description":{"en":"Chondroblastoma is a mostly benign bone neoplasm that typically affects the second decade of life and exhibits a lytic lesion in the epiphysis of long bones. We report an extreme case of massive, destructive chondroblastoma of the proximal humerus in a 9-year-old girl. It was difficult to differentiate using imaging information the lesion from malignant bone tumors such as osteosarcoma. Histopathological examination from biopsy proved chondroblastoma. The tumor was resected after preoperative transcatheter embolization. Reconstructive procedure for the proximal humerus was not performed due to the local destruction. The present case demonstrates clinical and radiological differentiations of the massive chondroblastoma from the other lesions and histopathological understandings for this lesion.","ja":"Chondroblastoma is a mostly benign bone neoplasm that typically affects the second decade of life and exhibits a lytic lesion in the epiphysis of long bones. We report an extreme case of massive, destructive chondroblastoma of the proximal humerus in a 9-year-old girl. It was difficult to differentiate using imaging information the lesion from malignant bone tumors such as osteosarcoma. Histopathological examination from biopsy proved chondroblastoma. The tumor was resected after preoperative transcatheter embolization. Reconstructive procedure for the proximal humerus was not performed due to the local destruction. The present case demonstrates clinical and radiological differentiations of the massive chondroblastoma from the other lesions and histopathological understandings for this lesion."},"publication_date":"2013-03-25","publication_name":{"en":"Case Reports in Orthopedics","ja":"Case Reports in Orthopedics"},"volume":"2013","starting_page":"673576","ending_page":"673576","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1155/2013/673576"],"issn":["2090-6749"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:8, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/22735610","label":"url"},{"@id":"https://www.scopus.com/pages/publications/84864969156","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=430279","label":"url"}],"paper_title":{"en":"Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma","ja":"Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma"},"authors":{"en":[{"name":"Morita Yoshihiro"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"Nishisho Toshihiko"},{"name":"Yura Yoshiaki"},{"name":"Yoneda Toshiyuki"}],"ja":[{"name":"Morita Yoshihiro"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"西庄 俊彦"},{"name":"Yura Yoshiaki"},{"name":"Yoneda Toshiyuki"}]},"description":{"en":"Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism underlying OSCC metastasis to regional lymph nodes, the highly metastatic fluorescent labeled OSCC cell line SAS-LM3 was successfully established allowing us to monitor the progression of lymph node metastases in a non-invasive manner. SAS-LM3 tumors showed increased lymphangiogenesis and elevated expression of VEGF-C, a potent stimulator of lymphangiogenesis, compared to parental SAS tumors. SAS-LM3 showed high expression of cyclooxygenase-2 (COX-2) compared to parental SAS cells and immunohistochemical analysis demonstrated intense COX-2 expression at the primary site. Inactivation of COX-2 by knockdown or the COX-2 inhibitor NS-398 decreased VEGF-C expression. Administration of COX-2 inhibitor NS-398 in SAS-LM3 tumor-bearing mice suppressed tumor lymphangiogenesis and lymphatic metastases. Collectively, our results indicate that COX-2 promotes tumor lymphangiogenesis and lymph node metastasis of OSCC. COX-2 ablation holds promise as a potential therapeutic approach for lymph node metastasis in OSCC.","ja":"Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism underlying OSCC metastasis to regional lymph nodes, the highly metastatic fluorescent labeled OSCC cell line SAS-LM3 was successfully established allowing us to monitor the progression of lymph node metastases in a non-invasive manner. SAS-LM3 tumors showed increased lymphangiogenesis and elevated expression of VEGF-C, a potent stimulator of lymphangiogenesis, compared to parental SAS tumors. SAS-LM3 showed high expression of cyclooxygenase-2 (COX-2) compared to parental SAS cells and immunohistochemical analysis demonstrated intense COX-2 expression at the primary site. Inactivation of COX-2 by knockdown or the COX-2 inhibitor NS-398 decreased VEGF-C expression. Administration of COX-2 inhibitor NS-398 in SAS-LM3 tumor-bearing mice suppressed tumor lymphangiogenesis and lymphatic metastases. Collectively, our results indicate that COX-2 promotes tumor lymphangiogenesis and lymph node metastasis of OSCC. COX-2 ablation holds promise as a potential therapeutic approach for lymph node metastasis in OSCC."},"publication_date":"2012-06-25","publication_name":{"en":"International Journal of Oncology","ja":"International Journal of Oncology"},"volume":"41","number":"3","starting_page":"885","ending_page":"892","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3892/ijo.2012.1529"],"issn":["1019-6439"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:9, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21717996","label":"url"},{"@id":"https://www.scopus.com/pages/publications/79960193241","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=431181","label":"url"}],"paper_title":{"en":"Locally administered zoledronic acid therapy for giant cell tumor of bone","ja":"Locally administered zoledronic acid therapy for giant cell tumor of bone"},"authors":{"en":[{"name":"Nishisho Toshihiko"},{"name":"Hanaoka Naoyoshi"},{"name":"Endo Kenji"},{"name":"Takahashi Mitsuhiko"},{"name":"Yasui Natsuo"}],"ja":[{"name":"西庄 俊彦"},{"name":"Hanaoka Naoyoshi"},{"name":"遠藤 健次"},{"name":"高橋 光彦"},{"name":"安井 夏生"}]},"description":{"en":"Giant cell tumor of bone is locally aggressive and occurs in the meta-epiphyseal region of long bones. Because of its high recurrence rate, local adjuvant therapies such as phenol or liquid nitrogen have been recommended. In the present study, zoledronic acid, a nitrogen-containing bisphosphonate, was administered locally as an adjuvant during a biopsy. An otherwise healthy 43-year-old man presented with pain and swelling in the right knee. Plain radiographs showed an osteolytic lesion of the right proximal tibia. An open biopsy was performed and the intraoperative pathologic diagnosis was giant cell tumor of bone. Following biopsy, the defect was filled with betatricalcium phosphate, and 4 mg of zoledronic acid was locally administered into the tumor lesion. Two months after the biopsy, curettage and bone grafting were performed. Sections were obtained during the curettage for histology to evaluate the response to bisphosphonate treatment. Histologic examination revealed massive tumor cell death in the lesion in which both stromal cells and osteoclast-like giant cells were necrotic. Curettage was performed and the defect was filled with a commercial preshaped hydroxyapatitetricalcium phosphate bone substitute. Eighteen months after curettage, the patient had regained full range of motion and good function of the knee, and radiographs at 18 months after curettage revealed no recurrence of giant cell tumor of bone.","ja":"Giant cell tumor of bone is locally aggressive and occurs in the meta-epiphyseal region of long bones. Because of its high recurrence rate, local adjuvant therapies such as phenol or liquid nitrogen have been recommended. In the present study, zoledronic acid, a nitrogen-containing bisphosphonate, was administered locally as an adjuvant during a biopsy. An otherwise healthy 43-year-old man presented with pain and swelling in the right knee. Plain radiographs showed an osteolytic lesion of the right proximal tibia. An open biopsy was performed and the intraoperative pathologic diagnosis was giant cell tumor of bone. Following biopsy, the defect was filled with betatricalcium phosphate, and 4 mg of zoledronic acid was locally administered into the tumor lesion. Two months after the biopsy, curettage and bone grafting were performed. Sections were obtained during the curettage for histology to evaluate the response to bisphosphonate treatment. Histologic examination revealed massive tumor cell death in the lesion in which both stromal cells and osteoclast-like giant cells were necrotic. Curettage was performed and the defect was filled with a commercial preshaped hydroxyapatitetricalcium phosphate bone substitute. Eighteen months after curettage, the patient had regained full range of motion and good function of the knee, and radiographs at 18 months after curettage revealed no recurrence of giant cell tumor of bone."},"publication_date":"2011-07-07","publication_name":{"en":"Orthopedics","ja":"Orthopedics"},"volume":"34","number":"7","starting_page":"e312","ending_page":"e315","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3928/01477447-20110526-22"],"issn":["0147-7447"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:10, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21669964","label":"url"},{"@id":"https://www.scopus.com/pages/publications/79960661431","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=431168","label":"url"}],"paper_title":{"en":"The a3 isoform vacuolar type H +-ATPase promotes distant metastasis in the mouse B16 melanoma cells","ja":"The a3 isoform vacuolar type H +-ATPase promotes distant metastasis in the mouse B16 melanoma cells"},"authors":{"en":[{"name":"Nishisho Toshihiko"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"Morita Yoshihiro"},{"name":"Sun-Wada Ge Hong"},{"name":"Wada Yoh"},{"name":"Yasui Natsuo"},{"name":"Yoneda Toshiyuki"}],"ja":[{"name":"西庄 俊彦"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"Morita Yoshihiro"},{"name":"Sun-Wada Ge Hong"},{"name":"Wada Yoh"},{"name":"安井 夏生"},{"name":"Yoneda Toshiyuki"}]},"description":{"en":"Accumulating evidence indicates that the acidic microenvironments critically influence malignant behaviors of cancer including invasiveness, metastasis, and chemoresistance. Because the vacuolar-type H(+)-ATPase (V-ATPase) has been shown to cause extracellular acidification by pumping protons, we studied the role of V-ATPase in distant metastasis. Real-time PCR analysis revealed that the high-metastatic B16-F10 melanoma cells strongly expressed the a3 isoform V-ATPase compared to the low-metastatic B16 parental cells. Consistent with this, B16-F10 cells created acidic environments in lung metastases by acridine orange staining and strong a3 V-ATPase expression in bone metastases by immunohistochemistry. Immunocytochemical analysis showed B16-F10 cells expressed a3 V-ATPase not only in cytoplasm but also plasma membrane, whereas B16 parental cells exhibited its expression only in cytoplasm. Of note, knockdown of a3 V-ATPase suppressed invasiveness and migration with reduced MMP-2 and MMP-9 expression in B16-F10 cells and significantly decreased lung and bone metastases, despite that tumor growth was not altered. Importantly, administration of a specific V-ATPase a3 inhibitor FR167356 reduced bone metastasis of B16-F10 cells. These results suggest that a3 V-ATPase promotes distant metastasis of B16-F10 cells by creating acidic environments via proton secretion. Our results also suggest that inhibition of the development of cancer-associated acidic environments by suppressing a3 V-ATPase could be a novel therapeutic approach for the treatment of cancer metastasis.","ja":"Accumulating evidence indicates that the acidic microenvironments critically influence malignant behaviors of cancer including invasiveness, metastasis, and chemoresistance. Because the vacuolar-type H(+)-ATPase (V-ATPase) has been shown to cause extracellular acidification by pumping protons, we studied the role of V-ATPase in distant metastasis. Real-time PCR analysis revealed that the high-metastatic B16-F10 melanoma cells strongly expressed the a3 isoform V-ATPase compared to the low-metastatic B16 parental cells. Consistent with this, B16-F10 cells created acidic environments in lung metastases by acridine orange staining and strong a3 V-ATPase expression in bone metastases by immunohistochemistry. Immunocytochemical analysis showed B16-F10 cells expressed a3 V-ATPase not only in cytoplasm but also plasma membrane, whereas B16 parental cells exhibited its expression only in cytoplasm. Of note, knockdown of a3 V-ATPase suppressed invasiveness and migration with reduced MMP-2 and MMP-9 expression in B16-F10 cells and significantly decreased lung and bone metastases, despite that tumor growth was not altered. Importantly, administration of a specific V-ATPase a3 inhibitor FR167356 reduced bone metastasis of B16-F10 cells. These results suggest that a3 V-ATPase promotes distant metastasis of B16-F10 cells by creating acidic environments via proton secretion. Our results also suggest that inhibition of the development of cancer-associated acidic environments by suppressing a3 V-ATPase could be a novel therapeutic approach for the treatment of cancer metastasis."},"publication_date":"2011-06-13","publication_name":{"en":"Molecular Cancer Research : MCR","ja":"Molecular Cancer Research : MCR"},"volume":"9","number":"7","starting_page":"845","ending_page":"855","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1158/1541-7786.MCR-10-0449"],"issn":["1541-7786"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:11, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21327980","label":"url"},{"@id":"https://www.scopus.com/pages/publications/80051607010","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=431195","label":"url"}],"paper_title":{"en":"Extraskeletal Ewing's sarcoma in a 67-year-old man","ja":"Extraskeletal Ewing's sarcoma in a 67-year-old man"},"authors":{"en":[{"name":"Hanaoka Naoyoshi"},{"name":"Goto Tomohiro"},{"name":"Kasai Tokio"},{"name":"Matsuura Tetsuya"},{"name":"Nishisho Toshihiko"},{"name":"Enishi Tetsuya"},{"name":"Yasui Natsuo"}],"ja":[{"name":"Hanaoka Naoyoshi"},{"name":"後東 知宏"},{"name":"Kasai Tokio"},{"name":"松浦 哲也"},{"name":"西庄 俊彦"},{"name":"Enishi Tetsuya"},{"name":"安井 夏生"}]},"publication_date":"2011-02-17","publication_name":{"en":"Journal of Orthopaedic Science","ja":"Journal of Orthopaedic Science"},"volume":"16","number":"2","starting_page":"250","ending_page":"252","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00776-011-0024-8"],"issn":["0949-2658"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:12, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20534813","label":"url"},{"@id":"https://www.scopus.com/pages/publications/77955104547","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=432178","label":"url"}],"paper_title":{"en":"Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: A potential mechanism of inflammatory pain","ja":"Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: A potential mechanism of inflammatory pain"},"authors":{"en":[{"name":"Nakanishi Masako"},{"name":"Hata Kenji"},{"name":"Nagayama Tomotaka"},{"name":"Sakurai Teruhisa"},{"name":"Nishisho Toshihiko"},{"name":"Wakabayashi Hiroki"},{"name":"Hiraga Toru"},{"name":"Ebisu Shigeyuki"},{"name":"Yoneda Toshiyuki"}],"ja":[{"name":"Nakanishi Masako"},{"name":"Hata Kenji"},{"name":"Nagayama Tomotaka"},{"name":"Sakurai Teruhisa"},{"name":"西庄 俊彦"},{"name":"Wakabayashi Hiroki"},{"name":"Hiraga Toru"},{"name":"Ebisu Shigeyuki"},{"name":"Yoneda Toshiyuki"}]},"description":{"en":"Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated in inflammatory pain. The inflammatory site is acidic due to proton release from infiltrating inflammatory cells. Acid activation of peripheral nociceptors relays pain signals to the CNS. Here, we examined whether acid activated the transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression. Chemically induced inflammation was associated with thermal hyperalgesia and increased CGRP expression in dorsal root ganglion (DRG) in rats. In organ cultures of DRG, acid (pH 5.5) elevated CGRP expression and the selective Trpv1 antagonist 5'-Iodoresiniferatoxin decreased it. Trpv1-deficient DRG showed reduced CGRP increase by acid. Of note, many of CGRP/Trpv1-positive DRG neurons exhibited the phosphorylation of cAMP response element-binding protein (CREB), a nociceptive transcription factor. Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression. Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity. These effects were inhibited by a Ca(2+)/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93. In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.","ja":"Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated in inflammatory pain. The inflammatory site is acidic due to proton release from infiltrating inflammatory cells. Acid activation of peripheral nociceptors relays pain signals to the CNS. Here, we examined whether acid activated the transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression. Chemically induced inflammation was associated with thermal hyperalgesia and increased CGRP expression in dorsal root ganglion (DRG) in rats. In organ cultures of DRG, acid (pH 5.5) elevated CGRP expression and the selective Trpv1 antagonist 5'-Iodoresiniferatoxin decreased it. Trpv1-deficient DRG showed reduced CGRP increase by acid. Of note, many of CGRP/Trpv1-positive DRG neurons exhibited the phosphorylation of cAMP response element-binding protein (CREB), a nociceptive transcription factor. Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression. Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity. These effects were inhibited by a Ca(2+)/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93. In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain."},"publication_date":"2010-06-09","publication_name":{"en":"Molecular Biology of the Cell","ja":"Molecular Biology of the Cell"},"volume":"21","number":"15","starting_page":"2568","ending_page":"2577","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1091/mbc.E10-01-0049"],"issn":["1059-1524"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:13, {"insert":{"user_id":"R000021451","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/17943297","label":"url"},{"@id":"https://www.scopus.com/pages/publications/35848931866","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=437583","label":"url"}],"paper_title":{"en":"Treatment of dysplastic osteoarthritis with labral tear by Chiari pelvic osteotomy: Outcomes after more than 10 years follow-up","ja":"Treatment of dysplastic osteoarthritis with labral tear by Chiari pelvic osteotomy: Outcomes after more than 10 years follow-up"},"authors":{"en":[{"name":"Nakano Shunji"},{"name":"Nishisho Toshihiko"},{"name":"Hamada Daisuke"},{"name":"Kosaka Hirofumi"},{"name":"Yukata Kiminori"},{"name":"Oba Koichi"},{"name":"Kawasaki Yoshiteru"},{"name":"Miyoshi Hideaki"},{"name":"Egawa Hiroshi"},{"name":"Kinoshita Isamu"},{"name":"Yasui Natsuo"}],"ja":[{"name":"中野 俊次"},{"name":"西庄 俊彦"},{"name":"Hamada Daisuke"},{"name":"Kosaka Hirofumi"},{"name":"油形 公則"},{"name":"Oba Koichi"},{"name":"川﨑 賀照"},{"name":"Miyoshi Hideaki"},{"name":"江川 洋史"},{"name":"Kinoshita Isamu"},{"name":"安井 夏生"}]},"description":{"en":"The presence of a damaged labrum is one of many factors influencing the outcomes of Chiari pelvic osteotomy. However, there are few previous papers describing the long-term outcomes of Chiari pelvic osteotomy with labrectomy. The purpose of this study was to evaluate the long-term clinical and radiological outcomes of Chiari pelvic osteotomy for dysplastic hips with labral tears. We compared outcomes between labrectomy (+) and labrectomy (-) groups. Chiari pelvic osteotomies were performed by one surgeon on 34 dysplastic hips with labral tears between 1983 and 1996, in which labrectomy was performed on 23 hips but not on 11 hips. Three patients undergoing labrectomy were lost to follow-up evaluation within 5 years after surgery. The average age of the remaining 31 patients was 35.5 years (range, 16-54 years). The clinical and radiographic surveillance averaged 16.0 years (range, 10-23.3 years). In all patients, pain disappeared after the operation. At the end of the study, 8 of the 31 patients displayed clinical deterioration. Progression of osteoarthritis (OA) was observed in 11 hips. Patients with poor results have not opted for revision surgery except for one patient. In the labrectomy (+) group, 10 of the 20 hips showed progression of OA and the clinical outcomes of 6 patients deteriorated. In the labrectomy (-) group, 1 of the 11 hips showed progression of OA and 2 patients deteriorated clinically. Radiological outcomes differed significantly between the two groups. Labrectomy accompanying Chiari pelvic osteotomy is an acceptable procedure for relieving pain caused by the damaged labrum, but the outcomes have a tendency to deteriorate after 10 or more years postoperatively.","ja":"The presence of a damaged labrum is one of many factors influencing the outcomes of Chiari pelvic osteotomy. However, there are few previous papers describing the long-term outcomes of Chiari pelvic osteotomy with labrectomy. The purpose of this study was to evaluate the long-term clinical and radiological outcomes of Chiari pelvic osteotomy for dysplastic hips with labral tears. We compared outcomes between labrectomy (+) and labrectomy (-) groups. Chiari pelvic osteotomies were performed by one surgeon on 34 dysplastic hips with labral tears between 1983 and 1996, in which labrectomy was performed on 23 hips but not on 11 hips. Three patients undergoing labrectomy were lost to follow-up evaluation within 5 years after surgery. The average age of the remaining 31 patients was 35.5 years (range, 16-54 years). The clinical and radiographic surveillance averaged 16.0 years (range, 10-23.3 years). In all patients, pain disappeared after the operation. At the end of the study, 8 of the 31 patients displayed clinical deterioration. Progression of osteoarthritis (OA) was observed in 11 hips. Patients with poor results have not opted for revision surgery except for one patient. In the labrectomy (+) group, 10 of the 20 hips showed progression of OA and the clinical outcomes of 6 patients deteriorated. In the labrectomy (-) group, 1 of the 11 hips showed progression of OA and 2 patients deteriorated clinically. Radiological outcomes differed significantly between the two groups. Labrectomy accompanying Chiari pelvic osteotomy is an acceptable procedure for relieving pain caused by the damaged labrum, but the outcomes have a tendency to deteriorate after 10 or more years postoperatively."},"publication_date":"2007-10-18","publication_name":{"en":"Archives of Orthopaedic and Trauma Surgery","ja":"Archives of Orthopaedic and Trauma Surgery"},"volume":"128","number":"1","starting_page":"103","ending_page":"109","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00402-007-0465-x"],"issn":["0936-8051"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:14, {"insert":{"user_id":"R000021451","type":"published_papers","id":"32451112"},"force":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/024270194","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1520009409854739968/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=267979","label":"url"}],"paper_title":{"en":"Treatment Strategy for Congenital Pseudarthrosis of the Tibia","ja":"難治性小児疾患の治療戦略 先天性下腿偽関節症の治療戦略(解説)"},"authors":{"en":[{"name":"Takahashi Mitsuhiko"},{"name":"Kawasaki Yoshiteru"},{"name":"高砂 智哉"},{"name":"Nishisho Toshihiko"},{"name":"Yasui Natsuo"}],"ja":[{"name":"高橋 光彦"},{"name":"川﨑 賀照"},{"name":"高砂 智哉"},{"name":"西庄 俊彦"},{"name":"安井 夏生"}]},"publication_date":"2013-01-30","publication_name":{"en":"The Journal of the Japanese Orthopaedic Association","ja":"日本整形外科學會雜誌"},"volume":"87","number":"1","starting_page":"32","ending_page":"37","languages":["jpn"],"invited":true,"identifiers":{"issn":["0021-5325"]},"published_paper_type":"research_institution"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/244268/researchmap/published_papers-propagate.jsonl, C8rRIqEBRJbN-uhaDkRY) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/244268/researchmap/misc-propagate.jsonl) ====
line:1, {"insert":{"user_id":"R000021451","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20637323","label":"url"},{"@id":"https://www.scopus.com/pages/publications/78650305975","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=432165","label":"url"}],"paper_title":{"en":"Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain","ja":"Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain"},"authors":{"en":[{"name":"Yoneda Toshiyuki"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"Nagae Maho"},{"name":"Nagayama Tomotaka"},{"name":"Wakabayashi Hiroki"},{"name":"Nishisho Toshihiko"},{"name":"Sakurai Teruhisa"},{"name":"Hiraga Toru"}],"ja":[{"name":"Yoneda Toshiyuki"},{"name":"Hata Kenji"},{"name":"Nakanishi Masako"},{"name":"Nagae Maho"},{"name":"Nagayama Tomotaka"},{"name":"Wakabayashi Hiroki"},{"name":"西庄 俊彦"},{"name":"Sakurai Teruhisa"},{"name":"Hiraga Toru"}]},"description":{"en":"Bone pain is one of the most common complications in cancer patients with bone metastases. Although the mechanism of cancer-associated bone pain is poorly understood, clinical observations that inhibitors of osteoclasts such as bisphosphonates (BPs) efficiently reduce bone pain suggest a potential role of osteoclasts, which play a central role in the development and progression of bone metastasis. Osteoclasts dissolve bone minerals by releasing protons through the a3 isoform of the vacuolar-H(+)-ATPase, creating acidic microenvironments. In addition, cancer cells, inflammatory cells and immune cells that reside in bone metastases also produce acidic conditions by releasing protons. It has been well-known that acidic conditions due to proton release cause pain. Our study showed that the sensory nociceptive neurons innervate bone and these neurons express acid-sensing nociceptors such as the acid-sensing ion channels and transient receptor potential channel-vanilloid subfamily members. Acid signals received by these nociceptors subsequently activate intracellular signaling pathways and transcription factors in sensory neurons. The understanding of the nociceptive events following proton release and subsequent creation of acidic microenvironments leads us to design novel molecular-based approaches for reducing bone pain associated with cancer and inflammation.","ja":"Bone pain is one of the most common complications in cancer patients with bone metastases. Although the mechanism of cancer-associated bone pain is poorly understood, clinical observations that inhibitors of osteoclasts such as bisphosphonates (BPs) efficiently reduce bone pain suggest a potential role of osteoclasts, which play a central role in the development and progression of bone metastasis. Osteoclasts dissolve bone minerals by releasing protons through the a3 isoform of the vacuolar-H(+)-ATPase, creating acidic microenvironments. In addition, cancer cells, inflammatory cells and immune cells that reside in bone metastases also produce acidic conditions by releasing protons. It has been well-known that acidic conditions due to proton release cause pain. Our study showed that the sensory nociceptive neurons innervate bone and these neurons express acid-sensing nociceptors such as the acid-sensing ion channels and transient receptor potential channel-vanilloid subfamily members. Acid signals received by these nociceptors subsequently activate intracellular signaling pathways and transcription factors in sensory neurons. The understanding of the nociceptive events following proton release and subsequent creation of acidic microenvironments leads us to design novel molecular-based approaches for reducing bone pain associated with cancer and inflammation."},"publication_date":"2010-07-14","publication_name":{"en":"Bone","ja":"Bone"},"volume":"48","number":"1","starting_page":"100","ending_page":"105","languages":["eng"],"identifiers":{"doi":["10.1016/j.bone.2010.07.009"],"issn":["8756-3282"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/244268/researchmap/misc-propagate.jsonl, CKTRIqEBn_HdSsNVXqA3) ====
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