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Tokushima University > Research Clusters > Research Clusters (Registered) > 1803001 要介護リスクを高める骨粗鬆症・関節リウマチにおける骨代謝制御機構とその破綻のエピゲノム解析 >
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Academic Paper (Judged Full Paper):

1. Naoko Ogasawara, Akihiko Iwasa, Shinya Horiuchi, Aki Ichihara, Akihiro Yasue, Nobuhiko Kawai, Takashi Izawa and Eiji Tanaka :
矯正患者における永久歯の先天性欠如に関する臨床統計調査,
The Journal of Chu-Shikoku Orthodontic Society, Vol.30, No.1, 59-64, 2018.
2. Akihiko Iwasa, Shinya Horiuchi, Nao Kinouchi, Takashi Izawa, Masahiro Hiasa, Nobuhiko Kawai, Akihiro Yasue, H Ali Hassan and Eiji Tanaka :
Skeletal anchorage for intrusion of bimaxillary molars in a patient with skeletal open bite and temporomandibular disorders.,
Journal of Orthodontic Science, Vol.6, No.4, 152-158, 2017.
(Tokushima University Institutional Repository: 113509,   DOI: 10.4103/jos.JOS_63_17,   PubMed: 29119097)
3. Islamy Rahma Hutami, Takashi Izawa, Akiko Mino, Takehiro Shinohara, Hiroki Mori, Akihiko Iwasa and Eiji Tanaka :
Fas/S1P1 crosstalk via NF-B activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis,
Biochemical and Biophysical Research Communications, Vol.490, No.4, 1274-1281, 2017.
(Tokushima University Institutional Repository: 113368,   DOI: 10.1016/j.bbrc.2017.07.006,   PubMed: 28687489)
4. Takehiro Shinohara, Takashi Izawa, Akiko Mino, Hiroki Mori, Akihiko Iwasa, Toshihiro Inubushi, Yu Yamaguchi and Eiji Tanaka :
Hyaluronan metabolism in overloaded temporomandibular joint,
Journal of Oral Rehabilitation, Vol.43, No.12, 921-928, 2016.
(DOI: 10.1111/joor.12443,   PubMed: 27627706,   Elsevier: Scopus)
5. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Correction: Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.,
PLoS ONE, Vol.11, No.8, e0162032, 2016.
(DOI: 10.1371/journal.pone.0162032,   PubMed: 27560140)
6. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis,
PLoS ONE, Vol.11, No.4, e0154107, 2016.
(Tokushima University Institutional Repository: 112307,   DOI: 10.1371/journal.pone.0154107,   PubMed: 27123995)
7. Akihiko Iwasa, Rieko Arakaki, Naoko Honma, Aya Ushio, Akiko Yamada, Tomoyuki Kondo, Emi Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka, Noriko Yoshimura, Nobuhiro Harada, Yoshio Hayashi and Naozumi Ishimaru :
Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.,
The American Journal of Pathology, Vol.185, No.1, 151-161, 2015.
(Tokushima University Institutional Repository: 113532,   DOI: 10.1016/j.ajpath.2014.09.006,   PubMed: 25447050,   Elsevier: Scopus)
8. Rieko Arakaki, Hiroshi Eguchi, Akiko Yamada, Yasusei Kudo, Akihiko Iwasa, Enkhmaa Tserennadmid, Hotta Fumika, Mitamura-Aizawa Sayaka, Yoshio Hayashi and Naozumi Ishimaru :
Anti-Inflammatory Effects of Rebamipide Eyedrop Administration on Ocular Lesions in a Murine Model of Primary Sjögren's Syndrome.,
PLoS ONE, Vol.9, No.5, e98390, 2014.
(Tokushima University Institutional Repository: 110973,   DOI: 10.1371/journal.pone.0098390,   PubMed: 24866156,   Elsevier: Scopus)

Proceeding of International Conference:

1. Tsendsuren Khurel-Ochir, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
The role of p21 on the development of TMJ-OA,
6th Meeting of Mongolian Association of Orthdontists,, Ulaanbaatar, Mongolia., Sep. 2018.
2. Islamy Rahma Hutami, Hiroki Mori, Tsendsuren Khurel-Ochir, Akiko Mino, Akihiko Iwasa, Eiji Tanaka and Takashi Izawa :
HIF-1alpha regulates the palatal wound healing through M1/M2 macrophage reprogramming,
96th General Session & Exhibition of the IADR, 214, London, Jul. 2018.
3. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Akihiko Iwasa and Eiji Tanaka :
Fas/S1P1 signaling controls temporomandibular joint subchondral bone remodeling in autoimmune-arthritis.,
95th General Session & Exhibition of the IADR program book, 243, San Francisco, Mar. 2017.
4. Minami Sato, Mutsumi Fujita, Akihiko Iwasa, Hiroki Mori, Akiko Mino, Natsuko Hichijo, Shinya Horiuchi and Eiji Tanaka :
Effect of Low-intensity Pulsed Ultrasound on ATDC5 Cells Under Inflammation,
95th General Session & Exhibition of the IADR program book, San Francisco, Mar. 2017.
5. Hiroki Mori, Takashi Izawa, Takehiro Shinohara, Akiko Mino, Minami Sato, Natsuko Hichijo, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
Effect of Rebamipide administration on TMJ-OA model mouse.,
95th General Session & Exhibition of the IADR program book, 207, San Francisco, Mar. 2017.
6. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
Pathologenesis of Sjogren's syndrome through Aromatase and adipose tissue.,
International Congress on Autoimmunity, Niece, Mar. 2014.
7. Koichi Yamada, Akihiko Iwasa, Tomoyuki Kondo, Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Y Taquahashi, A Takagi, J Kanno and Naozumi Ishimaru :
Invivo effect of multi-wall carbon nanotubes on immune system.,
6th International Symposium on Nanotechnology,Occupational and Environmental system., Nagoya, Nov. 2013.

Proceeding of Domestic Conference:

1. Akihiko Iwasa, Naoko Ogasawara, Masaki Sawada, Mohannad Ashtar, Shinya Horiuchi and Eiji Tanaka :
慢性辺縁性歯周炎を伴う骨格性II級叢生に対する歯科矯正用アンカースクリューを用いた包括的治療例,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page256.(2019), 256, Nov. 2019.
2. Takuma Sakamaki, Akihiko Iwasa, Hiroki Mori, Naoko Ogasawara, Kotaro Tanimoto, MOHANNAD ASHTAR, YAO LIU, Masaki Sawada, Tatsuya Nakamura, Shinya Horiuchi and Eiji Tanaka :
矯正治療中に生じた下顎中切歯の歯肉退縮に対して結合組織移植術を行った歯性上顎前突症例―長期保定症例,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, Jul. 2019.
3. Masaki Sawada, Akihiko Iwasa, Muneyuki Yoshimura, Aki Ichihara, Silvia Naomi Mitsui Akagi, 塩屋園 玲子, Masahiro Hiasa, Akihiro Yasue and Eiji Tanaka :
シルエットを用いた側貌に対する審美的評価,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, Jul. 2019.
4. Islamy Rahma Hutami, Hiroki Mori, Tsendsuren Khurel-Ochir, Akiko Mino, Akihiko Iwasa, Eiji Tanaka and Takashi Izawa :
HIF1α modulates the palatal wound healing via M1/M2 marcophage reprogramming.,
第66回国際歯科研究学会日本部会総会・学術大会(JADR2018), Nov. 2018.
5. Tsendsuren Khurel-Ochir, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
The role of p21 on the development of TMJ-OA,
The 77th Annual Meeting of the Japanese Orthodontic Society, Vol.77, 79, Nov. 2018.
6. Mutsumi Fujita, 重田 南, Hiroki Mori, Akihiko Iwasa, Nobuhiko Kawai and Eiji Tanaka :
変形性顎関節症モデルラット下顎頭及び炎症状態下軟骨細胞に対する低出力パルス超音波照射の影響,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 77回 Page320.(2018.10), 320, Oct. 2018.
7. 武川 香織, Akihiko Iwasa, Silvia Naomi Mitsui Akagi, Tomonari Kunida, Yusuke Matsuki, Takashi Yamamoto, Saki Saitoh, Nobuhiko Kawai and Eiji Tanaka :
歯科衛生士による歯科矯正患者に対する口腔筋機能療法に関する実態調査.,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 73-74, Jul. 2018.
8. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Akiko Oka, Tsendsuren Khurel-Ochir, Akihiko Iwasa and Eiji Tanaka :
低酸素応答遺伝子 HIF-1alpha は M1/M2 マクロファージの リプログラミングを介して口蓋創傷治癒を制御する.,
第42回日本口蓋裂学会総会・学術集会 抄録号, Vol.43, No.2, 182, May 2018.
9. Yasutomo Yoshihara, Yoshitaka Suzuki, Seiko Nakagawa, Akihiko Iwasa, Kouhei Kamoi, Kazuo Okura, Maki Hosoki, Eiji Tanaka and Yoshizo Matsuka :
睡眠衛生指導とパラタルスプリントにより睡眠時ブラキシズムをコントロールした症例,
Shikoku Dental Research, Mar. 2018.
10. Akihiko Iwasa, Haruna Konishi, Kana Fujimoto, Naoko Ogasawara, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka :
徳島大学病院矯正歯科患者における永久歯埋伏に関する臨床統計学的調査,
第76回日本矯正歯科学会学術大会, Oct. 2017.
11. Islamy Rahma Hutami, Takashi Izawa, Akihiko Iwasa, Akiko Mino, Tsendsuren Khurelochir, Hiroki Mori and Eiji Tanaka :
Role of hypoxia inducible factor-1 alpha in the palatal wound healing,
The 76th Annual Meeting of the Japanese Orthodontic Society Academic Exhibits (AE-012), 309, Oct. 2017.
12. Akihiko Iwasa, Takashi Izawa, Hiroki Mori, Akiko Oka, Mutsumi Fujita, Nobuhiko Kawai, Shinya Horiuchi and Eiji Tanaka :
歯科矯正患者における進行性下顎頭吸収の発現頻度とその危険因子の検索,
第30回日本顎関節学会総会・学術大会, Jul. 2017.
13. Mutsumi Fujita, 重田 南, Akihiko Iwasa, Hiroki Mori, Nobuhiko Kawai, Takashi Izawa, Shinya Horiuchi and Eiji Tanaka :
変形性顎関節症モデルラット下顎頭及び炎症状態下軟骨細胞に対する低出力パルス超音波による影響.,
Journal of the Japanese Society for the Temporomandibular Joint, Jul. 2017.
14. Kana Fujimoto, Haruna Konishi, Akihiko Iwasa, Aki Ichihara, Manami Shirai, Keiichiro Watanabe, Masahiro Hiasa, Hiroyo Mori, Shinya Horiuchi and Eiji Tanaka :
歯科矯正患者における埋伏永久歯に関する実態調査,
第60回中・四国矯正歯科学会大会, Jul. 2017.
15. Naoko Ogasawara, Akihiko Iwasa, Hiroko Sato, Mutsumi Fujita, Akiko Oka, Ayami Itoh, Natsuko Hichijo, Nobuhiko Kawai, Takashi Izawa and Eiji Tanaka :
矯正患者における永久歯の先天的欠如に関する臨床統計調査,
第60回中・四国矯正歯科学会大会, Jul. 2017.
16. Haruna Konishi, Kana Fujimoto, Akihiko Iwasa, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka :
不正咬合患者における埋伏歯についての臨床統計学的調査,
四国歯学会第50回例会, Mar. 2017.
17. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Takehiro Shinohara, Akiko Mino and Eiji Tanaka :
The role of osteoclast in the spontaneously developed temporomandibular joint arthritis of the MRL/lpr mice,
The 75th Annual Meeting of the Japanese Orthodontic Society, 321, Nov. 2016.
18. Akihiko Iwasa, Hiroki Mori, Takashi Izawa, Takehiro Shinohara, Akiko Mino, Minami Sato, Shinya Horiuchi and Eiji Tanaka :
Satistical survey of temporomandibular disorders in patients with malocclusion,
The 29th Annual Meeting of The Japanese Society for Temporomandibular Joint, Vol.28, No.Supplement, 145, Jul. 2016.
19. Takehiro Shinohara, Takashi Izawa, Akihiko Iwasa, Hiroki Mori, Akiko Mino, Toshihiro Inubushi and Eiji Tanaka :
Role of hyaluronan metabolism in experimentally induced temporomandibular joint osteoarthritis,
The 29th Annual Meeting of the Japanese Society for Temporomandibular Joint, Vol.28, No.Supplement, 123, Jul. 2016.
20. Hiroko Sato, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Nao Kinouchi, Shinya Horiuchi and Eiji Tanaka :
A case of Apert syndrome treated with two-jaw surgery after Le Fort III distraction osteogenesis,
第59回中・四国矯正歯科学会大会 学術口演, Jul. 2016.
21. Minami Sato, Akihiko Iwasa, Hiroki Mori, Shinya Horiuchi and Eiji Tanaka :
関節滑膜細胞に対する低出力超音波照射によって生じる抗炎症シグナル伝達経路の解明,
日本顎関節学会雑誌., 124., Jun. 2016.
22. Akiko Mino, Takashi Izawa, Takehiro Shinohara, Hiroki Mori, Hiroyo Mori, Akihiko Iwasa and Eiji Tanaka :
マウス下顎頭軟骨の形成,維持におけるHIF-1αの機能解析,
第74回日本矯正歯科学会大会プログラム・抄録集, 204, Nov. 2015.
23. Hiroki Mori, Takashi Izawa, Akiko Mino, Akihiko Iwasa, Ryoko Uchida and Eiji Tanaka :
S1P/Smad3シグナルクロストークを介した変形性顎関節症の病態メカニズムの解明,
第74回日本矯正歯科学会大会プログラム・抄録集, 194, Nov. 2015.
24. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Chieko Shiota, Toshihiro Inubushi, Akihiko Iwasa and Eiji Tanaka :
変形性顎関節症モデルマウスにおけるレパミピドの治療効果の検討,
第74回日本矯正歯科学会大会プログラム・抄録集, 193, Nov. 2015.
25. Kaoru Yoshinaga, Keiichiro Watanabe, Ruri Nakamura, Minami Sato, Silvia Naomi Mitsui Akagi, Ryota Amachi, Akihiko Iwasa, Shinya Horiuchi, Shingo Kuroda and Eiji Tanaka :
歯科矯正用アンカースクリューの導入による診断内容の変化∼抜歯・非抜歯および抜歯部位の判定に関する検討∼,
第58回中·四国矯正歯科学会大会, 18, Jul. 2015.
26. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akihiko Iwasa and Eiji Tanaka :
Effect of rebamipide administration on TMJ-OA model mouse,
Journal of the Japanese Society for the Temporomandibular Joint, Vol.27, No.Supplement, 148, Jul. 2015.
27. Akihiko Iwasa, Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
Relationship between aromatase-related obesity and autoimmunity in Sjogren's syndorome.,
Proceedings of the Japanese Society for Immunology, Dec. 2013.
28. Akihiko Iwasa, Naozumi Ishimaru, Takashi Izawa, 徳永 律子, Yasusei Kudo and Eiji Tanaka :
アロマターゼ遺伝子欠損マウスにおけるシェーグレン症候群様病変と肥満との関連,
第72回日本矯正歯科学会大会プログラム・抄録集, Oct. 2013.
29. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Yasusei Kudo and Naozumi Ishimaru :
アロマターぜ遺伝子欠損マウスにおけるシェーグレン症候群様病変と肥満との関連,
四国免疫ファオーラム, Jun. 2013.
30. Akihiko Iwasa, Tomoyuki Kondoh, Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
アロマターゼ遺伝子欠損マウスにおける肥満とシェーグレン症候群様病変との関連,
第102回日本病理学会, Jun. 2013.
31. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
The dysfunction of the aromatase worsens the pathogenesis of Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Dec. 2012.
32. Akihiko Iwasa, Nao Kinouchi, Kumiko Nagata, Shinya Horiuchi and Eiji Tanaka :
インプラント固定を用いて垂直的被蓋の改善を行った顎関節症を伴う骨格性開咬の治療例,
Journal of the Japanese Society for the Temporomandibular Joint, Vol.24, No.Suppl., 127, Nov. 2012.
33. Nao Kinouchi, Kyoko Ishimoto, Ritsuko 徳永 律子 Oura, Ryoko Uchida, Akihiko Iwasa, Takumi Takahashi, Shinya Horiuchi, Shingo Kuroda and Eiji Tanaka :
Influence of Hotz-type palatal plate with nasal stent on nasal form,
第71回日本矯正歯科学会大会プログラム・抄録集, 237, Sep. 2012.
34. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
A critical role of aromatase in the pathogenesis of Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Vol.40, 127, Nov. 2011.
35. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Ritsuko 徳永 律子 Oura, Akihiko Iwasa, Yoshio Hayashi and Eiji Tanaka :
関節リウマチモデルマウスにおける破骨細胞の機能亢進,
日本矯正歯科学会大会プログラム・抄録集, 218, Oct. 2011.
36. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Ritsuko 徳永 律子 Oura, Akihiko Iwasa, Yoshio Hayashi and Eiji Tanaka :
Analysis for mechanism of T cell activation via osteoclast in rheumatoid arthritis,
Journal of the Japanese Society for the Temporomandibular Joint, Vol.23, 102, Jul. 2011.
37. Akihiko Iwasa, Nao Kinouchi, Shinya Horiuchi and Eiji Tanaka :
Relationship between the mandibular deviation and masticatory path in skeletal Class III patients before and after orthognathic surgery,
Journal of the Japanese Society for the Temporomandibular Joint, Vol.23, 119, Jul. 2011.

Et cetera, Workshop:

1. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Takehiro Shinohara, Akiko Mino and Eiji Tanaka :
Fas/S1P system controls subchondral bone remodeling of the temporomandibular joint in autoimmune arthritic mice.,
2016 Tokushima Bioscience Retreat, Sep. 2016.
2. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino-Oka, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Correction: Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.,
PLoS ONE, Vol.11, No.8, e0162032, Aug. 2016.
(DOI: 10.1371/journal.pone.0162032,   PubMed: 27560140)
3. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis,
13th Meeting of Bone Biology Forum, Aug. 2016.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 顎顔面領域骨代謝性疾患におけるエピゲノム制御による新規骨リモデリング機構の解明 (Project/Area Number: 18H03011 )
  • 低酸素応答遺伝子を介した代謝リプログラミングによる口蓋瘢痕形成抑制への挑戦 (Project/Area Number: 17K19758 )
  • アロマターゼ遺伝子欠損マウスにおける肥満と慢性炎症病態の関連性の解明 (Project/Area Number: 17K17333 )
  • Relationship between aromatase-related obesity and autoimmunity in Sjögren's syndrome. (Project/Area Number: 15K20597 )
  • Challenge to analyze the regulatory mechanism of bone metabolism by dioxin receptor AhR (Project/Area Number: 15K15757 )
  • Search by Researcher Number (90746025)