=== Generating (published_papers) === === Generating (research_interests) === === Generating (teaching_experience) === === Generating (education) === === Generating (misc) === === Generating (research_projects) === === Generating (books_etc) === === Generating (committee_memberships) === === Generating (awards) === === Generating (association_memberships) === === Generating (presentations) === ==== begin registerFile(/WWW/pub2/data/ERD/person/264537/researchmap/published_papers-propagate.jsonl) ==== line:1, {"insert":{"user_id":"B000230696","type":"published_papers","id":"31279851"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26592145","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311246","label":"url"}],"paper_title":{"en":"Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia","ja":"Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia"},"authors":{"en":[{"name":"Fukushi Isato"},{"name":"Takeda Kotaro"},{"name":"Yokota Shigefumi"},{"name":"Hasebe Yohei"},{"name":"Sato Yutaka"},{"name":"Pokorski Mieczyslaw"},{"name":"Horiuchi Jouji"},{"name":"Okada Yasumasa"}],"ja":[{"name":"Fukushi Isato"},{"name":"Takeda Kotaro"},{"name":"Yokota Shigefumi"},{"name":"Hasebe Yohei"},{"name":"佐藤 裕"},{"name":"Pokorski Mieczyslaw"},{"name":"Horiuchi Jouji"},{"name":"Okada Yasumasa"}]},"description":{"en":"Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles in information processing in various brain functions. We investigated the hypothesis that astrocytic activation is necessary to maintain the cerebral function and ventilation in hypoxia, by examining the responses of EEG and ventilation to severe hypoxia before and after administration of a modulator of astrocytic function, arundic acid, in unanesthetized mice. Ventilatory parameters were measured by whole body plethysmography. When hypoxic ventilatory depression occurred, gamma frequency band of EEG was suppressed. Arundic acid further suppressed ventilation, and the EEG power was suppressed in a dose-dependent manner. Arundic acid also suppressed hypoxia-induced c-Fos expression in the hypothalamus. We conclude that severe hypoxia suppresses the cerebral function which could reduce the stimulus to the brainstem resulting in ventilatory depression. Astrocytic activation in hypoxia may counteract both cerebral and ventilatory suppression.","ja":"Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles in information processing in various brain functions. We investigated the hypothesis that astrocytic activation is necessary to maintain the cerebral function and ventilation in hypoxia, by examining the responses of EEG and ventilation to severe hypoxia before and after administration of a modulator of astrocytic function, arundic acid, in unanesthetized mice. Ventilatory parameters were measured by whole body plethysmography. When hypoxic ventilatory depression occurred, gamma frequency band of EEG was suppressed. Arundic acid further suppressed ventilation, and the EEG power was suppressed in a dose-dependent manner. Arundic acid also suppressed hypoxia-induced c-Fos expression in the hypothalamus. We conclude that severe hypoxia suppresses the cerebral function which could reduce the stimulus to the brainstem resulting in ventilatory depression. Astrocytic activation in hypoxia may counteract both cerebral and ventilatory suppression."},"publication_date":"2016-06","publication_name":{"en":"Respiratory Physiology & Neurobiology","ja":"Respiratory Physiology & Neurobiology"},"volume":"226","starting_page":"24","ending_page":"29","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.resp.2015.11.011"],"issn":["1878-1519"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} line:2, {"insert":{"user_id":"B000230696","type":"published_papers","id":"31279873"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=335590","label":"url"}],"paper_title":{"en":"小学生の読みにおける音韻処理の発達的変化 -語彙判断・押韻判断処理における脳処理からの検討-","ja":"小学生の読みにおける音韻処理の発達的変化 -語彙判断・押韻判断処理における脳処理からの検討-"},"authors":{"en":[{"name":"Sato Yutaka"},{"name":"山根 直人"}],"ja":[{"name":"佐藤 裕"},{"name":"山根 直人"}]},"publication_date":"2017-10","publication_name":{"en":"明治安田こころの健康財団 2016年度研究助成 論文集","ja":"明治安田こころの健康財団 2016年度研究助成 論文集"},"volume":"52","starting_page":"70","ending_page":"78","languages":["jpn"],"published_paper_type":"research_institution"},"priority":"input_data"} ==== end registerFile(/WWW/pub2/data/ERD/person/264537/researchmap/published_papers-propagate.jsonl, hrl1RaABn_HdSsNV2M9G) ==== ==== begin registerFile(/WWW/pub2/data/ERD/person/264537/researchmap/presentations-propagate.jsonl) ==== line:1, {"insert":{"user_id":"B000230696","type":"presentations","id":"51481183"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=457096","label":"url"}],"presentation_title":{"en":"糖尿病治療に用いられるGLP-1受容体作動薬が呼吸に与える影響","ja":"糖尿病治療に用いられるGLP-1受容体作動薬が呼吸に与える影響"},"presenters":{"en":[{"name":"福士 勇人"},{"name":"横田 茂文"},{"name":"武田 湖太郎"},{"name":"Sato Yutaka"},{"name":"糸賀 正道"},{"name":"梅田 啓"},{"name":"田坂 定智"},{"name":"岡田 泰昌"}],"ja":[{"name":"福士 勇人"},{"name":"横田 茂文"},{"name":"武田 湖太郎"},{"name":"佐藤 裕"},{"name":"糸賀 正道"},{"name":"梅田 啓"},{"name":"田坂 定智"},{"name":"岡田 泰昌"}]},"event":{"en":"第35回日本呼吸ケア・リハビリテーション学会学術集会","ja":"第35回日本呼吸ケア・リハビリテーション学会学術集会"},"publication_date":"2025-10-25","languages":["jpn"],"location":{"en":"新潟市","ja":"新潟市"},"is_international_presentation":false},"priority":"input_data"} line:2, {"insert":{"user_id":"B000230696","type":"presentations","id":"51481184"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=457098","label":"url"}],"presentation_title":{"en":"Effects of glucagon-like peptide-1 (GLP-1) receptor agonist exenatide on ventilatory control in healthy mice","ja":"Effects of glucagon-like peptide-1 (GLP-1) receptor agonist exenatide on ventilatory control in healthy mice"},"presenters":{"en":[{"name":"Fukushi Isato"},{"name":"Yokota Shigefumi"},{"name":"Takeda Kotaro"},{"name":"Sato Yutaka"},{"name":"Itoga Masamichi"},{"name":"Umeda Akira"},{"name":"Tasaka Sadatomo"},{"name":"Okada Yasumasa"}],"ja":[{"name":"Fukushi Isato"},{"name":"Yokota Shigefumi"},{"name":"Takeda Kotaro"},{"name":"佐藤 裕"},{"name":"Itoga Masamichi"},{"name":"Umeda Akira"},{"name":"Tasaka Sadatomo"},{"name":"Okada Yasumasa"}]},"event":{"en":"第30回日本基礎理学療法学会学術大会","ja":"第30回日本基礎理学療法学会学術大会"},"publication_date":"2025-10-17","languages":["eng"],"location":{"en":"別府市","ja":"別府市"},"is_international_presentation":false},"priority":"input_data"} line:3, {"insert":{"user_id":"B000230696","type":"presentations","id":"51481185"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=457097","label":"url"}],"presentation_title":{"en":"GLP-1受容体作動薬exenatideが低酸素換気応答に及ぼす影響","ja":"GLP-1受容体作動薬exenatideが低酸素換気応答に及ぼす影響"},"presenters":{"en":[{"name":"福士 勇人"},{"name":"横田 茂文"},{"name":"武田 湖太郎"},{"name":"Sato Yutaka"},{"name":"糸賀 正道"},{"name":"梅田 啓"},{"name":"田坂 定智"},{"name":"岡田 泰昌"}],"ja":[{"name":"福士 勇人"},{"name":"横田 茂文"},{"name":"武田 湖太郎"},{"name":"佐藤 裕"},{"name":"糸賀 正道"},{"name":"梅田 啓"},{"name":"田坂 定智"},{"name":"岡田 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