type: misc

label: url

en: 多胎 二卵性, 一卵性多胎

ja: 多胎 二卵性, 一卵性多胎

en: Clinical Gynecology and Obstetrics

ja: 臨床婦人科産科


en: 黄体ホルモン製剤の種類と使い方

ja: 黄体ホルモン製剤の種類と使い方

en: Obstetrical and Gynecological Practice

ja: 産婦人科の実際


en: 黄体ホルモンと生殖補助医療

ja: 黄体ホルモンと生殖補助医療

en: Obstet. Gynecol. (tokyo)

ja: 産科と婦人科


en: 新鮮胚移植と凍結胚移植の安全性

ja: 新鮮胚移植と凍結胚移植の安全性


en: 卵巣老化とPGT-A

ja: 卵巣老化とPGT-A


en: 【画像! エキスパート直伝 産婦人科画像診断】生殖内分泌 .機能性囊胞, 黄体囊胞, 排卵・黄体,卵巣出血


en: 耐糖能異常

ja: 耐糖能異常


en: がん治療後の内分泌環境の変化

ja: がん治療後の内分泌環境の変化

en: Journal of Fertility Preservation

ja: 日本がん·生殖医療学会誌


en: Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms.

en: It is known that metabolic disturbances suppress reproductive functions in females. The mechanisms underlying metabolic and nutritional effects on reproductive functions have been established based on a large body of clinical and experimental data. From the 1980s to 1990s, it was revealed that disrupted gonadotropin-releasing hormone (GnRH) secretion is the main cause of reproductive impairments in metabolic and nutritional disorders. From the late 1990s to early 2000s, it was demonstrated that, in addition to their primary functions, some appetite- or metabolism-regulating factors affect GnRH secretion. Furthermore, in the early 2000s, kisspeptin, which is a potent positive regulator of GnRH secretion, was newly discovered, and it has been revealed that kisspeptin integrates the effects of metabolic status on GnRH neurons. Recent studies have shown that kisspeptin mediates at least some of the effects of appetite- and metabolism-regulating factors on GnRH neurons. Thus, kisspeptin might be a useful clinical target for treatments aimed at restoring reproductive functions in individuals with metabolic or nutritional disturbances, such as those who exercise excessively, experience marked weight loss, or suffer from eating disorders. This paper presents a review of what is currently known about the effects of metabolic status on reproductive functions and their underlying mechanisms by summarizing the available evidence.

en: Journal of Clinical Medicine

ja: Journal of Clinical Medicine