{"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37489628","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85165549223&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=402341","label":"url"}],"paper_title":{"en":"Lymph node dissection during radical cystectomy for bladder cancer: A two-center comparative study of robotic versus open surgery.","ja":"Lymph node dissection during radical cystectomy for bladder cancer: A two-center comparative study of robotic versus open surgery."},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"Daizumoto Kei"},{"name":"Fukuta Kyotaro"},{"name":"Shiozaki Keito"},{"name":"Nishiyama Mitsuki"},{"name":"Utsunomiya Seiya"},{"name":"Kobayashi Saki"},{"name":"Seto Kosuke"},{"name":"Ueno Yoshiteru"},{"name":"Tomida Ryotaro"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Nakanishi Ryoichi"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Izaki Hirofumi"},{"name":"Takahashi Masayuki"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"大豆本 圭"},{"name":"Fukuta Kyotaro"},{"name":"Shiozaki Keito"},{"name":"Nishiyama Mitsuki"},{"name":"Utsunomiya Seiya"},{"name":"Kobayashi Saki"},{"name":"Seto Kosuke"},{"name":"Ueno Yoshiteru"},{"name":"Tomida Ryotaro"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"Nakanishi Ryoichi"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"Izaki Hirofumi"},{"name":"高橋 正幸"}]},"description":{"en":"This study was performed to evaluate the safety and efficacy of lymph node dissection (LND) during robot-assisted radical cystectomy (RARC) compared with open radical cystectomy (ORC). From October 2003 to December 2021, 122 patients underwent LND during RARC and 103 patients underwent LND during ORC at Tokushima University Hospital and Tokushima Prefectural Central Hospital. We investigated the safety and efficacy of LND during RARC by comparing the surgical and oncological outcomes between the two groups. The patients were significantly older in the RARC than the ORC group. The operative time was significantly shorter and the estimated blood loss was significantly lower in the RARC than the ORC group. Although the lymph node yield was significantly higher in the RARC than the ORC group, there was no significant difference in lymph node positivity between the groups. There was no significant difference in the incidence of local recurrence or distant metastasis between the two groups. The 5-year survival rates (overall survival, cancer-specific survival, and recurrence-free survival) were not different between the RARC and ORC groups. This study suggests that the surgical and oncological safety and efficacy of LND during RARC are greater than those of LND during ORC. We believe that LND during RARC is a higher-quality procedure than LND during ORC.","ja":"This study was performed to evaluate the safety and efficacy of lymph node dissection (LND) during robot-assisted radical cystectomy (RARC) compared with open radical cystectomy (ORC). From October 2003 to December 2021, 122 patients underwent LND during RARC and 103 patients underwent LND during ORC at Tokushima University Hospital and Tokushima Prefectural Central Hospital. We investigated the safety and efficacy of LND during RARC by comparing the surgical and oncological outcomes between the two groups. The patients were significantly older in the RARC than the ORC group. The operative time was significantly shorter and the estimated blood loss was significantly lower in the RARC than the ORC group. Although the lymph node yield was significantly higher in the RARC than the ORC group, there was no significant difference in lymph node positivity between the groups. There was no significant difference in the incidence of local recurrence or distant metastasis between the two groups. The 5-year survival rates (overall survival, cancer-specific survival, and recurrence-free survival) were not different between the RARC and ORC groups. This study suggests that the surgical and oncological safety and efficacy of LND during RARC are greater than those of LND during ORC. We believe that LND during RARC is a higher-quality procedure than LND during ORC."},"publication_date":"2023-07-25","publication_name":{"en":"Asian Journal of Endoscopic Surgery","ja":"Asian Journal of Endoscopic Surgery"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/ases.13234"],"issn":["1758-5910"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37355721","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399092","label":"url"}],"paper_title":{"en":"Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma.","ja":"Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma."},"authors":{"en":[{"name":"Takahashi Masayuki"},{"name":"Daizumoto Kei"},{"name":"Fukawa Tomoya"},{"name":"Fukuhara Yayoi"},{"name":"Bando Yoshimi"},{"name":"Kowada Minoru"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Sasaki Yutaro"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Uehara Hisanori"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"高橋 正幸"},{"name":"大豆本 圭"},{"name":"布川 朋也"},{"name":"福原 弥生"},{"name":"坂東 良美"},{"name":"Kowada Minoru"},{"name":"Dondoo Tsogt-Ochir"},{"name":"佐々木 雄太郎"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"上原 久典"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1.","ja":"Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1."},"publication_date":"2023-06-24","publication_name":{"en":"British Journal of Cancer","ja":"British Journal of Cancer"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41416-023-02325-8"],"issn":["1532-1827"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37070175","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399089","label":"url"}],"paper_title":{"en":"Efficacy of fresh-frozen cadaveric surgical training for arteriovenous fistula in vascular access.","ja":"Efficacy of fresh-frozen cadaveric surgical training for arteriovenous fistula in vascular access."},"authors":{"en":[{"name":"Hori Katsuhito"},{"name":"Sasaki Yutaro"},{"name":"Shiozaki Keito"},{"name":"Kadoriku Fumiya"},{"name":"Daizumoto Kei"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Takahashi Masayuki"},{"name":"Tsuruo Yoshihiro"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"Hori Katsuhito"},{"name":"佐々木 雄太郎"},{"name":"Shiozaki Keito"},{"name":"Kadoriku Fumiya"},{"name":"大豆本 圭"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"高橋 正幸"},{"name":"鶴尾 吉宏"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"CST for AVF creation is useful for surgical education because it enables learning of surgical techniques that are almost equivalent to those in living bodies. In addition, this study suggested that CST not only contributes to the improvement of surgical skills of young surgeons but also promotes the reduction of anxiety and stress about AVF creation.","ja":"Twelve CST sessions were performed on nine FFCs. All training sessions allowed completion of AVF creation with a median operative time of 78.5 min. Although veins and arteries were more difficult to identify than in a living body, other surgical operations could be performed in the same way as in a living body. All the respondents stated that it was good for them to experience CST. In addition, 86% of surgeons responded that CST improved their surgical techniques, and 71% of surgeons responded that they were less anxious about AVF creation."},"publication_date":"2023-04-17","publication_name":{"en":"The Journal of Vascular Access","ja":"The Journal of Vascular Access"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1177/11297298231169056"],"issn":["1724-6032"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36840720","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85149381419&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399088","label":"url"}],"paper_title":{"en":"Assistent guide: A novel device for ureteral stent placement in robot-assisted intracorporeal ileal conduit.","ja":"Assistent guide: A novel device for ureteral stent placement in robot-assisted intracorporeal ileal conduit."},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"Takahashi Masayuki"},{"name":"Fukuta Kyotaro"},{"name":"Shiozaki Keito"},{"name":"Daizumoto Kei"},{"name":"Ueno Yoshiteru"},{"name":"Tomida Ryotaro"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Izaki Hirofumi"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"高橋 正幸"},{"name":"Fukuta Kyotaro"},{"name":"Shiozaki Keito"},{"name":"大豆本 圭"},{"name":"Ueno Yoshiteru"},{"name":"Tomida Ryotaro"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"井崎 博文"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"We showed the safety and efficacy of the Assistent guide for ureteral stent placement in RICIC.","ja":"We showed the safety and efficacy of the Assistent guide for ureteral stent placement in RICIC."},"publication_date":"2023-03-02","publication_name":{"en":"The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS","ja":"The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS"},"volume":"Vol.19","number":"No.4","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/rcs.2513"],"issn":["1478-596X"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118311","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37164748","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399093","label":"url"}],"paper_title":{"en":"The impact of nutritional status and changes of body composition on the prognosis of metastatic renal cell carcinoma patients.","ja":"The impact of nutritional status and changes of body composition on the prognosis of metastatic renal cell carcinoma patients."},"authors":{"en":[{"name":"Ozaki Keisuke"},{"name":"Fukawa Tomoya"},{"name":"Daizumoto Kei"},{"name":"Sasaki Yutaro"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Uchida Takayuki"},{"name":"Kusuhara Yoshito"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"Ozaki Keisuke"},{"name":"布川 朋也"},{"name":"大豆本 圭"},{"name":"佐々木 雄太郎"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"内田 貴之"},{"name":"楠原 義人"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"Nutritional status of mRCC patients may predict changes in body composition and be associated with their prognosis. J. Med. Invest. 70 : 80-87, February, 2023.","ja":"Nutritional status of mRCC patients may predict changes in body composition and be associated with their prognosis. J. Med. Invest. 70 : 80-87, February, 2023."},"publication_date":"2023","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.70","number":"No.1.2","starting_page":"80","ending_page":"87","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.70.80"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36881090","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399091","label":"url"}],"paper_title":{"en":"Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer.","ja":"Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer."},"authors":{"en":[{"name":"Ueno Yoshiteru"},{"name":"Fukumori Tomoharu"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Tsuda Megumi"},{"name":"Daizumoto Kei"},{"name":"Sasaki Yutaro"},{"name":"Tomida Ryotaro"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Tonoiso Chisato"},{"name":"Kubo Akiko"},{"name":"Kawanaka Takashi"},{"name":"Furutani Shunsuke"},{"name":"Ikushima Hitoshi"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"Ueno Yoshiteru"},{"name":"福森 知治"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"津田 恵"},{"name":"大豆本 圭"},{"name":"佐々木 雄太郎"},{"name":"Tomida Ryotaro"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"外礒 千智"},{"name":"久保 亜貴子"},{"name":"川中 崇"},{"name":"古谷 俊介"},{"name":"生島 仁史"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"PSA levels at 5 years post-treatment were associated with long-term recurrence of localized prostate cancer, which can help alleviate patient anxiety concerning prostate cancer recurrence if PSA levels remain low at 5 years after LDR-BT.","ja":"PSA levels at 5 years post-treatment were associated with long-term recurrence of localized prostate cancer, which can help alleviate patient anxiety concerning prostate cancer recurrence if PSA levels remain low at 5 years after LDR-BT."},"publication_date":"2023","publication_name":{"en":"In Vivo","ja":"In Vivo"},"volume":"Vol.37","number":"No.2","starting_page":"738","ending_page":"746","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/invivo.13136"],"issn":["1791-7549"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400486","label":"url"}],"paper_title":{"en":"未固定凍結遺体を用いた心停止下献腎摘出教育の試み","ja":"未固定凍結遺体を用いた心停止下献腎摘出教育の試み"},"authors":{"en":[{"name":"尾﨑 啓介"},{"name":"Yamaguchi Kunihisa"},{"name":"多田 亜沙香"},{"name":"Fukawa Tomoya"},{"name":"Sasaki Yutaro"},{"name":"Kusuhara Yoshito"},{"name":"Yamamoto Yasuyo"},{"name":"林 秀樹"},{"name":"Takahashi Masayuki"},{"name":"Tsuruo Yoshihiro"},{"name":"橋本 寛文"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"尾﨑 啓介"},{"name":"山口 邦久"},{"name":"多田 亜沙香"},{"name":"布川 朋也"},{"name":"佐々木 雄太郎"},{"name":"楠原 義人"},{"name":"山本 恭代"},{"name":"林 秀樹"},{"name":"高橋 正幸"},{"name":"鶴尾 吉宏"},{"name":"橋本 寛文"},{"name":"金山 博臣"}]},"publication_date":"2022-12","publication_name":{"en":"日本臨床腎移植学会雑誌","ja":"日本臨床腎移植学会雑誌"},"volume":"Vol.10","number":"No.2","starting_page":"259","ending_page":"261","languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118156","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36448456","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399090","label":"url"}],"paper_title":{"en":"Comparison of robot-assisted partial nephrectomy with soft coagulation and double-layer technique for complex and non-complex tumors.","ja":"Comparison of robot-assisted partial nephrectomy with soft coagulation and double-layer technique for complex and non-complex tumors."},"authors":{"en":[{"name":"Shiozaki Keito"},{"name":"Izumi Kazuyoshi"},{"name":"Sasaki Yutaro"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Izaki Hirofumi"},{"name":"Takahashi Masayuki"},{"name":"Kawanishi Yasuo"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"Shiozaki Keito"},{"name":"Izumi Kazuyoshi"},{"name":"佐々木 雄太郎"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"井崎 博文"},{"name":"高橋 正幸"},{"name":"Kawanishi Yasuo"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"Single-layer suturing with soft coagulation achieves renal function and perioperative outcomes comparable to those of double-layer suturing regardless of complexity.","ja":"Single-layer suturing with soft coagulation achieves renal function and perioperative outcomes comparable to those of double-layer suturing regardless of complexity."},"publication_date":"2022-11-30","publication_name":{"en":"International Journal of Urology","ja":"International Journal of Urology"},"volume":"Vol.30","number":"No.3","starting_page":"281","ending_page":"288","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/iju.15112"],"issn":["1442-2042"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118559","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36344965","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85141380657&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399086","label":"url"}],"paper_title":{"en":"A propensity score matching study on robot-assisted radical cystectomy for older patients: comparison of intracorporeal ileal conduit and cutaneous ureterostomy.","ja":"A propensity score matching study on robot-assisted radical cystectomy for older patients: comparison of intracorporeal ileal conduit and cutaneous ureterostomy."},"authors":{"en":[{"name":"Kadoriku Fumiya"},{"name":"Sasaki Yutaro"},{"name":"Fukuta Kyotaro"},{"name":"Atagi Yuichiro"},{"name":"Shiozaki Keito"},{"name":"Daizumoto Kei"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yanagihara Yutaka"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Izaki Hirofumi"},{"name":"Takahashi Masayuki"},{"name":"Yamashi Sadamu"},{"name":"Kan Masaharu"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"Kadoriku Fumiya"},{"name":"佐々木 雄太郎"},{"name":"Fukuta Kyotaro"},{"name":"Atagi Yuichiro"},{"name":"Shiozaki Keito"},{"name":"大豆本 圭"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"Yanagihara Yutaka"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"井崎 博文"},{"name":"高橋 正幸"},{"name":"Yamashi Sadamu"},{"name":"Kan Masaharu"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"In older patients, the ICIC group showed non-inferior surgical and oncological outcomes compared with the CUS group. Urinary diversion following RARC in older patients should be carefully selected by considering not only the age but also the general condition (including comorbidities) of the patient.","ja":"The median age was lower in the ICIC group compared with the CUS group, and the proportion of high-risk cases (ECOG-PS ≥ 2 or ASA-PS ≥ 3) did not differ. The median operation time was longer in the ICIC group, and estimated blood loss was higher, compared with the CUS group. There were no significant differences in the incidence of complications within the first 30 postoperative days, incidence of complications 30-90 days after surgery, 2-year overall survival, 2-year cancer-specific survival, and 2-year recurrence-free survival. The stent-free rate was significantly lower in the CUS group than that in the ICIC group."},"publication_date":"2022-11-07","publication_name":{"en":"BMC Urology","ja":"BMC Urology"},"volume":"Vol.22","number":"No.1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/s12894-022-01123-3"],"issn":["1471-2490"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118791","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36605682","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399087","label":"url"}],"paper_title":{"en":"Recurrent multiple liver metastases of clear cell renal cell carcinoma with a significant response to sunitinib after nivolumab treatment.","ja":"Recurrent multiple liver metastases of clear cell renal cell carcinoma with a significant response to sunitinib after nivolumab treatment."},"authors":{"en":[{"name":"Tada Kouki"},{"name":"Daizumoto Kei"},{"name":"Takahashi Masayuki"},{"name":"Uehara Hisanori"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"Tada Kouki"},{"name":"大豆本 圭"},{"name":"高橋 正幸"},{"name":"上原 久典"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"金山 博臣"}]},"description":{"en":"Sunitinib after an IO-drug showed a significant effect in spite of only slight efficacy with other VEGFR-TKIs, which may have occurred through the alteration of the immunological microenvironment.","ja":"The patient was a 65-year-old man who underwent open nephrectomy for RCC. After the nephrectomy, he had recurrences several times, and metastasectomy had been performed for each recurrence. At 13 years after the nephrectomy, multiple liver, and lung metastases appeared. The treatment was switched to axitinib, followed by cabozantinib, then nivolumab. The best response was PR, SD, and PD for these three drugs, and treatment duration was 14, 3, and 3 months, respectively. As the fifth line, sunitinib was administered, with significant shrinkage of the multiple liver metastases, and PR has been maintained for 34 months."},"publication_date":"2022-10-18","publication_name":{"en":"IJU Case Reports","ja":"IJU Case Reports"},"volume":"Vol.6","number":"No.1","starting_page":"41","ending_page":"44","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/iju5.12545"],"issn":["2577-171X"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118219","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35851694","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=389088","label":"url"}],"paper_title":{"en":"Appropriate management reduces radiation exposure in daily urological practice","ja":"Appropriate management reduces radiation exposure in daily urological practice"},"authors":{"en":[{"name":"Ozaki K."},{"name":"Kawanaka Takashi"},{"name":"Fukawa Tomoya"},{"name":"Daizumoto Kei"},{"name":"Sasaki Yutaro"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"尾崎 啓介"},{"name":"川中 崇"},{"name":"布川 朋也"},{"name":"大豆本 圭"},{"name":"佐々木 雄太郎"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"To identify and raise awareness of the radiation exposure of urologists due to X-ray fluoroscopic procedures in daily practice. This was a single-center, cohort study of 30 consecutive patients who underwent periodic percutaneous or transurethral replacements of urinary tract catheters. A total of 55 replacements every 3 months with cases aligned were performed by a single urologist. The urologist's radiation exposure and the incident dose to patients per case were measured with thermoluminescent dosimeters. In the latter 3-month period, the pulse fluoroscopy condition was changed from 15 to 7.5 pulses per second, and collimation was added to the field of view. In the analysis of all patients, the use of a modified pulse rate and collimation did not affect the fluoroscopy time, but it did significantly reduce the air kerma and dose area product; in addition, with respect to the medical exposure dose during percutaneous catheter replacement, fluoroscopy time was longer, but air kerma and dose area product showed significant decreases. As with decreases in medical exposure of patients, the equivalent dose for eye lenses of the urologist decreased from 1.2 mSv in the first 3-month period to 0.2 mSv in the second 3-month period. Similarly, the exposure dose for the extremities also decreased significantly, from 33.9 mSv to 8.1 mSv. Urologists are exposed to non-negligible amounts of radiation due to fluoroscopy. Appropriate management such as modified pulse fluoroscopy condition and precautions are required.","ja":"To identify and raise awareness of the radiation exposure of urologists due to X-ray fluoroscopic procedures in daily practice. This was a single-center, cohort study of 30 consecutive patients who underwent periodic percutaneous or transurethral replacements of urinary tract catheters. A total of 55 replacements every 3 months with cases aligned were performed by a single urologist. The urologist's radiation exposure and the incident dose to patients per case were measured with thermoluminescent dosimeters. In the latter 3-month period, the pulse fluoroscopy condition was changed from 15 to 7.5 pulses per second, and collimation was added to the field of view. In the analysis of all patients, the use of a modified pulse rate and collimation did not affect the fluoroscopy time, but it did significantly reduce the air kerma and dose area product; in addition, with respect to the medical exposure dose during percutaneous catheter replacement, fluoroscopy time was longer, but air kerma and dose area product showed significant decreases. As with decreases in medical exposure of patients, the equivalent dose for eye lenses of the urologist decreased from 1.2 mSv in the first 3-month period to 0.2 mSv in the second 3-month period. Similarly, the exposure dose for the extremities also decreased significantly, from 33.9 mSv to 8.1 mSv. Urologists are exposed to non-negligible amounts of radiation due to fluoroscopy. Appropriate management such as modified pulse fluoroscopy condition and precautions are required."},"publication_date":"2022-07-18","publication_name":{"en":"International Journal of Urology","ja":"International Journal of Urology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/iju.14971"],"issn":["1442-2042"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35842843","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=389089","label":"url"}],"paper_title":{"en":"Efficacy of the Mercedes-Benz closure technique for vaginal reconstruction in female robot-assisted radical cystectomy","ja":"Efficacy of the Mercedes-Benz closure technique for vaginal reconstruction in female robot-assisted radical cystectomy"},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"Daizumoto Kei"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"大豆本 圭"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"金山 博臣"}]},"description":{"en":"Vaginal reconstruction using the posterior vaginal wall is required following radical cystectomy in women with resection of the uterus, adnexa, and anterior vaginal wall. Roll closure and clamshell closure are two widely known techniques. Of these, clamshell closure is recommended because roll closure has a high likelihood of breakdown or a resultant canal that is too narrow for sexual intercourse. In clamshell closure, however, folding the posterior vaginal wall anteriorly can be difficult. Therefore, we devised Mercedes-Benz closure, in which the vaginal wall is sutured from three directions to form a Mercedes-Benz shape, for anastomosis without tension on the vaginal wall. The present study was performed to investigate the efficacy of this alternative surgical technique for vaginal reconstruction. Twenty-six patients who underwent vaginal reconstruction following robot-assisted radical cystectomy were divided into two groups: 15 underwent clamshell closure and 11 underwent Mercedes-Benz closure. The patients' characteristics and surgical outcomes were compared between the two groups. There were no significant differences in clinical characteristics, including age, body mass index, and prior abdominal surgery between the two groups. The median vaginal reconstruction time tended to be longer in the Mercedes-Benz closure group than in the clamshell closure group (35.0 vs. 27.0 min, p = 0.102). No complications associated with vaginal reconstruction were identified. The surgical outcomes were comparable between Mercedes-Benz closure and clamshell closure. If vaginal reconstruction with clamshell closure is difficult, Mercedes-Benz closure is a valuable alternative technique.","ja":"Vaginal reconstruction using the posterior vaginal wall is required following radical cystectomy in women with resection of the uterus, adnexa, and anterior vaginal wall. Roll closure and clamshell closure are two widely known techniques. Of these, clamshell closure is recommended because roll closure has a high likelihood of breakdown or a resultant canal that is too narrow for sexual intercourse. In clamshell closure, however, folding the posterior vaginal wall anteriorly can be difficult. Therefore, we devised Mercedes-Benz closure, in which the vaginal wall is sutured from three directions to form a Mercedes-Benz shape, for anastomosis without tension on the vaginal wall. The present study was performed to investigate the efficacy of this alternative surgical technique for vaginal reconstruction. Twenty-six patients who underwent vaginal reconstruction following robot-assisted radical cystectomy were divided into two groups: 15 underwent clamshell closure and 11 underwent Mercedes-Benz closure. The patients' characteristics and surgical outcomes were compared between the two groups. There were no significant differences in clinical characteristics, including age, body mass index, and prior abdominal surgery between the two groups. The median vaginal reconstruction time tended to be longer in the Mercedes-Benz closure group than in the clamshell closure group (35.0 vs. 27.0 min, p = 0.102). No complications associated with vaginal reconstruction were identified. The surgical outcomes were comparable between Mercedes-Benz closure and clamshell closure. If vaginal reconstruction with clamshell closure is difficult, Mercedes-Benz closure is a valuable alternative technique."},"publication_date":"2022-07-17","publication_name":{"en":"Asian Journal of Endoscopic Surgery","ja":"Asian Journal of Endoscopic Surgery"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/ases.13109"],"issn":["1758-5910"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://search.jamas.or.jp/link/ui/2022255956","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390573715168780160/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400485","label":"url"}],"paper_title":{"en":"A Case of Pappilary Renal Cell Caircinoma which Responded Well to the Combination Therapy of Ipilimumab and Nivolumab --A CASE REPORT--","ja":"イピリムマブ・ニボルマブ併用療法が著効した乳頭状腎細胞癌の1例"},"authors":{"en":[{"name":"Fukatani Yusuke"},{"name":"Daizumoto Kei"},{"name":"Kadoriku Fumiya"},{"name":"山本 拓"},{"name":"Sasaki Yutaro"},{"name":"尾﨑 啓介"},{"name":"上野 恵輝"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"},{"name":"Niki Mariko"},{"name":"Uehara Hisanori"}],"ja":[{"name":"深谷 友祐"},{"name":"大豆本 圭"},{"name":"角陸 文哉"},{"name":"山本 拓"},{"name":"佐々木 雄太郎"},{"name":"尾﨑 啓介"},{"name":"上野 恵輝"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"},{"name":"仁木 真理子"},{"name":"上原 久典"}]},"description":{"en":"We report a case of papillary renal cell carcinoma that responded well to the combination of ipilimumab and nivolumab. The patient was a 68-year-old male who was being followed up for a small left renal mass without treatment. Two years later, computed tomography (CT) showed enlarged cervical and para-aortic lymph nodes, and lymph node biopsy suggested metastases of the cancer. After resection of the renal tumor, we performed pararenal aortic lymph node biopsy, and we diagnosed the case as papillary renal cell carcinoma type 1 with lymph node metastasis. The combination of ipilimumab and nivolumab each metastatic site showed regression on CT. Since immune-related adverse events occurred during the therapy nivolumab was discontinued, but partial response of the metastases was maintained.","ja":"We report a case of papillary renal cell carcinoma that responded well to the combination of ipilimumab and nivolumab. The patient was a 68-year-old male who was being followed up for a small left renal mass without treatment. Two years later, computed tomography (CT) showed enlarged cervical and para-aortic lymph nodes, and lymph node biopsy suggested metastases of the cancer. After resection of the renal tumor, we performed pararenal aortic lymph node biopsy, and we diagnosed the case as papillary renal cell carcinoma type 1 with lymph node metastasis. The combination of ipilimumab and nivolumab each metastatic site showed regression on CT. Since immune-related adverse events occurred during the therapy nivolumab was discontinued, but partial response of the metastases was maintained."},"publication_date":"2022-04-30","publication_name":{"en":"Acta Urologica Japonica","ja":"泌尿器科紀要"},"volume":"Vol.68","number":"No.4","starting_page":"107","ending_page":"111","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.14989/actauroljap_68_4_107"],"issn":["0018-1994"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116363","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34081290","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=389091","label":"url"}],"paper_title":{"en":"The patient-side surgeon plays a key role in facilitating robot-assisted intracorporeal ileal conduit urinary diversion in men","ja":"The patient-side surgeon plays a key role in facilitating robot-assisted intracorporeal ileal conduit urinary diversion in men"},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"Takahashi Masayuki"},{"name":"Daizumoto Kei"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"高橋 正幸"},{"name":"大豆本 圭"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"金山 博臣"}]},"description":{"en":"The influence of the console surgeon on the feasibility and outcome of various robot-assisted surgeries has been evaluated. These variables may be partially affected by the skills of the patient-side surgeon (PSS), but this has not been evaluated using objective data. This study aimed to describe the surgical techniques of the PSS in robot-assisted radical cystectomy (RARC) and intracorporeal ileal conduit (ICIC) urinary diversion and objectively examine the changes in surgical outcomes with increasing PSS experience. During a 3-year period, 28 men underwent RARC and ICIC urinary diversion. Clinical characteristics and surgical outcomes were compared between patients who underwent surgery early (first half group) or late in the study period (second half group). The pre-docking incision enabled easy specimen removal. The glove port technique widened the working space of the PSS. The stay suture allowed the PSS to control the distal portion of the conduit, facilitating the passage of the ureteral stents. During stoma creation, pneumoperitoneum pressure was lost by opening the abdominal cavity. To overcome this problem, the robotic arm was used to lift the abdominal wall to maintain the surgical field and facilitate the PSS procedure. Compared with the first half group, the second half group had significantly shorter times for urinary diversion (202 min vs 148 min, p < 0.001), ileal isolation and anastomosis (73 min vs 45 min, p < 0.001), and stenting (23.0 min vs 6.5 min, p < 0.001). As the experience of the PSS increased, the time of the PSS procedures decreased.","ja":"The influence of the console surgeon on the feasibility and outcome of various robot-assisted surgeries has been evaluated. These variables may be partially affected by the skills of the patient-side surgeon (PSS), but this has not been evaluated using objective data. This study aimed to describe the surgical techniques of the PSS in robot-assisted radical cystectomy (RARC) and intracorporeal ileal conduit (ICIC) urinary diversion and objectively examine the changes in surgical outcomes with increasing PSS experience. During a 3-year period, 28 men underwent RARC and ICIC urinary diversion. Clinical characteristics and surgical outcomes were compared between patients who underwent surgery early (first half group) or late in the study period (second half group). The pre-docking incision enabled easy specimen removal. The glove port technique widened the working space of the PSS. The stay suture allowed the PSS to control the distal portion of the conduit, facilitating the passage of the ureteral stents. During stoma creation, pneumoperitoneum pressure was lost by opening the abdominal cavity. To overcome this problem, the robotic arm was used to lift the abdominal wall to maintain the surgical field and facilitate the PSS procedure. Compared with the first half group, the second half group had significantly shorter times for urinary diversion (202 min vs 148 min, p < 0.001), ileal isolation and anastomosis (73 min vs 45 min, p < 0.001), and stenting (23.0 min vs 6.5 min, p < 0.001). As the experience of the PSS increased, the time of the PSS procedures decreased."},"publication_date":"2022-04","publication_name":{"en":"Journal of Robotic Surgery","ja":"Journal of Robotic Surgery"},"volume":"Vol.16","number":"No.2","starting_page":"437","ending_page":"444","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s11701-021-01256-x"],"issn":["1863-2491"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36244775","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399079","label":"url"}],"paper_title":{"en":"Clinical application of virtual imaging guided Robot-assisted partial nephrectomy.","ja":"Clinical application of virtual imaging guided Robot-assisted partial nephrectomy."},"authors":{"en":[{"name":"Shiozaki Keito"},{"name":"Kawanishi Yasuo"},{"name":"Sasaki Yutaro"},{"name":"Daizumoto Kei"},{"name":"Tsuda Megumi"},{"name":"Izumi Kazuyoshi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"Shiozaki Keito"},{"name":"Kawanishi Yasuo"},{"name":"佐々木 雄太郎"},{"name":"大豆本 圭"},{"name":"Tsuda Megumi"},{"name":"Izumi Kazuyoshi"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"Objectives : To evaluate whether virtual partial nephrectomy images could help surgeons identify vascular and collecting system around tumors during actual surgery. Materials & methods : We retrospectively analyzed 36 patients who underwent robot-assisted partial nephrectomy (RAPN) between 2016 and 2017. Virtual partial nephrectomy images were created from preoperative CT images using computer software, and then analyzed. For analysis, blood vessels and collecting system portions within a 5-mm-thick safety margin around the tumor were examined. During analysis, we predicted whether targeted vasculature around the tumor would require clipping or suturing during surgery, and also whether the collecting system would require opening during resection. Surgical outcomes for virtual partial nephrectomy analyses and actual RAPNs were compared and analyzed for sensitivity and specificity. Results : In 36 cases, 119 arteries and 100 veins were targeted on virtual partial nephrectomy images. Arterial suturing or clipping for hemostasis showed a sensitivity and specificity of 83.3% and 84.5%, respectively. For veins, the sensitivity and specificity were 39.1% and 92.2%, respectively. Collecting system opening prediction sensitivity was 85.7%, and specificity was 65.2%. Conclusion : Virtual partial nephrectomy imaging is useful for RAPN planning, particularly regarding arteries and the collecting system. It is hoped that techniques for visualizing veins will improve. J. Med. Invest. 69 : 237-243, August, 2022.","ja":"Objectives : To evaluate whether virtual partial nephrectomy images could help surgeons identify vascular and collecting system around tumors during actual surgery. Materials & methods : We retrospectively analyzed 36 patients who underwent robot-assisted partial nephrectomy (RAPN) between 2016 and 2017. Virtual partial nephrectomy images were created from preoperative CT images using computer software, and then analyzed. For analysis, blood vessels and collecting system portions within a 5-mm-thick safety margin around the tumor were examined. During analysis, we predicted whether targeted vasculature around the tumor would require clipping or suturing during surgery, and also whether the collecting system would require opening during resection. Surgical outcomes for virtual partial nephrectomy analyses and actual RAPNs were compared and analyzed for sensitivity and specificity. Results : In 36 cases, 119 arteries and 100 veins were targeted on virtual partial nephrectomy images. Arterial suturing or clipping for hemostasis showed a sensitivity and specificity of 83.3% and 84.5%, respectively. For veins, the sensitivity and specificity were 39.1% and 92.2%, respectively. Collecting system opening prediction sensitivity was 85.7%, and specificity was 65.2%. Conclusion : Virtual partial nephrectomy imaging is useful for RAPN planning, particularly regarding arteries and the collecting system. It is hoped that techniques for visualizing veins will improve. J. Med. Invest. 69 : 237-243, August, 2022."},"publication_date":"2022","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.69","number":"No.3.4","starting_page":"237","ending_page":"243","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.69.237"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390855656035011840/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391380","label":"url"}],"paper_title":{"en":"Two Cases of Robot-Assisted Total Pelvic Exenteration and Intracorporeal Ileal Conduit for Locally Advanced Rectal Cancer","ja":"局所進行直腸癌に対してロボット支援骨盤内臓全摘除術および体腔内回腸導管造設術を施行した2例"},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"安宅 真利花"},{"name":"多田 航生"},{"name":"中西 亮太"},{"name":"橋本 啓佑"},{"name":"吉岡 拓哉"},{"name":"Daizumoto Kei"},{"name":"Ozaki Keisuke"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"},{"name":"Kashihara Hideya"},{"name":"Tokunaga Takuya"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"安宅 真利花"},{"name":"多田 航生"},{"name":"中西 亮太"},{"name":"橋本 啓佑"},{"name":"吉岡 拓哉"},{"name":"大豆本 圭"},{"name":"尾崎 啓介"},{"name":"上野 恵輝"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"},{"name":"柏原 秀也"},{"name":"徳永 卓哉"}]},"publication_date":"2021-04-30","publication_name":{"en":"Acta Urologica Japonica","ja":"泌尿器科紀要"},"volume":"Vol.68","number":"No.5","starting_page":"155","ending_page":"159","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.14989/actauroljap_68_5_155"],"issn":["0018-1994"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34107613","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85108011497&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391374","label":"url"}],"paper_title":{"en":"A Case of Robot-Assisted Radical Cystoprostatectomy for Locally Advanced Prostate Cancer with Bladder Infiltration","ja":"膀胱浸潤を来たした局所進行性前立腺癌に対してロボット支援腹腔鏡下膀胱前立腺全摘除術を施行した1例"},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"角陸 文哉"},{"name":"深谷 友祐"},{"name":"山本 拓"},{"name":"Daizumoto Kei"},{"name":"Ozaki Keisuke"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"角陸 文哉"},{"name":"深谷 友祐"},{"name":"山本 拓"},{"name":"大豆本 圭"},{"name":"尾崎 啓介"},{"name":"上野 恵輝"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"While robot-assisted radical cystoprostatectomy (RARC) for locally advanced prostate cancer (LAPC) may sometimes prove to be excessive treatment, it can significantly reduce the risk of positive surgical margins and lower urinary tract obstruction in some cases. Here, we report a case of LAPC treated with RARC in a patient with right hydronephrosis due to bladder infiltration and left hypoplastic kidney. A 71-year-old man presented with frequent urination in August 2019. Prostate-specific antigen (PSA) level was 8.633 ng/ml, and magnetic resonance imaging led to the suspicion that the prostate cancer extended beyond the prostate capsule without distant metastasis. Prostatic biopsy revealed Gleason score 10 (5+5) adenocarcinoma in 8 out of 8 specimens. We diagnosed left hypoplastic kidney and LAPC with right hydronephrosis due to bladder infiltration. We performed percutaneous right nephrostomy and started neoadjuvant hormone therapy. RARC and intracorporeal ileal conduit were performed in March 2020. The prostate was adherent to the anterior surface of the rectum and was difficult to remove. At present, five months after the surgery, the patient remains free of recurrence and metastasis with PSA level <0.003 ng/ml. RARC for LAPC with bladder infiltration can be an effective therapeutic strategy in some cases.","ja":"While robot-assisted radical cystoprostatectomy (RARC) for locally advanced prostate cancer (LAPC) may sometimes prove to be excessive treatment, it can significantly reduce the risk of positive surgical margins and lower urinary tract obstruction in some cases. Here, we report a case of LAPC treated with RARC in a patient with right hydronephrosis due to bladder infiltration and left hypoplastic kidney. A 71-year-old man presented with frequent urination in August 2019. Prostate-specific antigen (PSA) level was 8.633 ng/ml, and magnetic resonance imaging led to the suspicion that the prostate cancer extended beyond the prostate capsule without distant metastasis. Prostatic biopsy revealed Gleason score 10 (5+5) adenocarcinoma in 8 out of 8 specimens. We diagnosed left hypoplastic kidney and LAPC with right hydronephrosis due to bladder infiltration. We performed percutaneous right nephrostomy and started neoadjuvant hormone therapy. RARC and intracorporeal ileal conduit were performed in March 2020. The prostate was adherent to the anterior surface of the rectum and was difficult to remove. At present, five months after the surgery, the patient remains free of recurrence and metastasis with PSA level <0.003 ng/ml. RARC for LAPC with bladder infiltration can be an effective therapeutic strategy in some cases."},"publication_date":"2021-04-30","publication_name":{"en":"Acta Urologica Japonica","ja":"泌尿器科紀要"},"volume":"Vol.67","number":"No.4","starting_page":"163","ending_page":"166","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.14989/ActaUrolJap_67_4_163"],"issn":["0018-1994"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116511","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34759153","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=389094","label":"url"}],"paper_title":{"en":"Efficacy of the direct grasping technique using pean forceps under fluoroscopy to replace ureteral stents in women","ja":"Efficacy of the direct grasping technique using pean forceps under fluoroscopy to replace ureteral stents in women"},"authors":{"en":[{"name":"Sasaki Yutaro"},{"name":"Takahashi Masayuki"},{"name":"Ozaki Keisuke"},{"name":"Daizumoto Kei"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"佐々木 雄太郎"},{"name":"高橋 正幸"},{"name":"Ozaki Keisuke"},{"name":"大豆本 圭"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"金山 博臣"}]},"description":{"en":"Purpose : To evaluate the efficacy of the direct grasping technique using pean forceps under fluoroscopic guidance for ureteral stent replacement in women. Methods : Between April 2018 and September 2020, 28 female patients underwent ureteral stent replacements at our facility, and 184 stent replacement procedures were performed. A total of 127 stents were replaced using pean forceps under fluoroscopic guidance (pean forceps group), and 57 stents were replaced using the cystoscope (cystoscopy group). Clinical characteristics and surgical outcomes were compared between the groups. Results : All stents were successfully replaced. There was a statistically significant difference in the procedure time between the two groups (median [interquartile range], pean forceps group : 10.8 [8.2-13.9] minutes vs. cystoscopy group : 15.8 [11.1-20.9] minutes, P < 0.001). There were no intraoperative complications in either group and no difference in the incidence of postoperative complications (pean forceps group : 1.6% vs. cystoscopy group : 1.8%, P = 1.000). Fluoroscopy time was longer in the pean forceps group, although this difference was not statistically significant (pean forceps group : 38.9 [22.6-60.1] seconds vs. cystoscopy group : 33.0 [20.0-48.9] seconds, P = 0.0558). Conclusion : The direct grasping technique using pean forceps under fluoroscopy may be a beneficial alternative to cystoscopy for ureteral stent replacement in women. J. Med. Invest. 68 : 326-329, August, 2021.","ja":"Purpose : To evaluate the efficacy of the direct grasping technique using pean forceps under fluoroscopic guidance for ureteral stent replacement in women. Methods : Between April 2018 and September 2020, 28 female patients underwent ureteral stent replacements at our facility, and 184 stent replacement procedures were performed. A total of 127 stents were replaced using pean forceps under fluoroscopic guidance (pean forceps group), and 57 stents were replaced using the cystoscope (cystoscopy group). Clinical characteristics and surgical outcomes were compared between the groups. Results : All stents were successfully replaced. There was a statistically significant difference in the procedure time between the two groups (median [interquartile range], pean forceps group : 10.8 [8.2-13.9] minutes vs. cystoscopy group : 15.8 [11.1-20.9] minutes, P < 0.001). There were no intraoperative complications in either group and no difference in the incidence of postoperative complications (pean forceps group : 1.6% vs. cystoscopy group : 1.8%, P = 1.000). Fluoroscopy time was longer in the pean forceps group, although this difference was not statistically significant (pean forceps group : 38.9 [22.6-60.1] seconds vs. cystoscopy group : 33.0 [20.0-48.9] seconds, P = 0.0558). Conclusion : The direct grasping technique using pean forceps under fluoroscopy may be a beneficial alternative to cystoscopy for ureteral stent replacement in women. J. Med. Invest. 68 : 326-329, August, 2021."},"publication_date":"2021","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.3.4","number":"No.68","starting_page":"326","ending_page":"329","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.326"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32882124","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85090318500&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=379545","label":"url"}],"paper_title":{"en":"[A Case of Pelvic Organ Prolapse and Bladder Diverticulum Surgically Treated at the Same Time].","ja":"骨盤臓器脱と膀胱憩室を同時に治療した1例"},"authors":{"en":[{"name":"Yamamoto Yasuyo"},{"name":"Fukawa Tomoya"},{"name":"Tsuda Megumi"},{"name":"Yano Tetsuhiro"},{"name":"Daizumoto Kei"},{"name":"Sasaki Yutaro"},{"name":"Ozaki Keisuke"},{"name":"Ueno Yoshiteru"},{"name":"Kusuhara Yoshito"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"山本 恭代"},{"name":"布川 朋也"},{"name":"津田 恵"},{"name":"矢野 哲弘"},{"name":"大豆本 圭"},{"name":"佐々木 雄太郎"},{"name":"尾﨑 啓介"},{"name":"上野 恵輝"},{"name":"楠原 義人"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"We report a case of bladder diverticulum presumably caused by lower urinary tract dysfunction due to pelvic organ prolapse (POP) simultaneously treated with transurethral coagulation (TUC) of the bladder diverticulum and laparoscopic sacrocolpopexy (LSC). A literature search showed this is the first report of bladder diverticulum and POP surgically treated at the same time. A 71-year-old woman was referred to our hospital for the treatment of cystocele. She had both storage and voiding symptoms. She had a POPQ stage III cystocele and stage I uterine prolapse. Ultrasonography and computed tomographic scan showed a large volume of residual urine along with a bladder diverticulum. Since urodynamic studies revealed a low compliance bladder and obstruction, we opined that the lower urinary tract symptoms were induced by the cystocele. TUC of the bladder diverticulum and LSC were performed at the same time. After the operation, clean intermittent catheterization (CIC) was needed once a day for one month. Gradually, residual urine decreased and CIC became unnecessary. The bladder diverticulum disappeared, and there has been no recurrence of POP.","ja":"We report a case of bladder diverticulum presumably caused by lower urinary tract dysfunction due to pelvic organ prolapse (POP) simultaneously treated with transurethral coagulation (TUC) of the bladder diverticulum and laparoscopic sacrocolpopexy (LSC). A literature search showed this is the first report of bladder diverticulum and POP surgically treated at the same time. A 71-year-old woman was referred to our hospital for the treatment of cystocele. She had both storage and voiding symptoms. She had a POPQ stage III cystocele and stage I uterine prolapse. Ultrasonography and computed tomographic scan showed a large volume of residual urine along with a bladder diverticulum. Since urodynamic studies revealed a low compliance bladder and obstruction, we opined that the lower urinary tract symptoms were induced by the cystocele. TUC of the bladder diverticulum and LSC were performed at the same time. After the operation, clean intermittent catheterization (CIC) was needed once a day for one month. Gradually, residual urine decreased and CIC became unnecessary. The bladder diverticulum disappeared, and there has been no recurrence of POP."},"publication_date":"2020-08","publication_name":{"en":"Acta Urologica Japonica","ja":"泌尿器科紀要"},"volume":"Vol.66","number":"No.8","starting_page":"269","ending_page":"272","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.14989/ActaUrolJap_66_8_269"],"issn":["0018-1994"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30711948","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=355460","label":"url"}],"paper_title":{"en":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer.","ja":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer."},"authors":{"en":[{"name":"Kusuhara Yoshito"},{"name":"Daizumoto Kei"},{"name":"Kawai Kaichi"},{"name":"Hirayama Kento"},{"name":"Kowada Minoru"},{"name":"Shintani Terumichi"},{"name":"Fukuhara Yayoi"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Ozaki Keisuke"},{"name":"Tsuda Megumi"},{"name":"Fukawa Tomoya"},{"name":"Nakatsuji Hiroyoshi"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"楠原 義人"},{"name":"大豆本 圭"},{"name":"Kawai Kaichi"},{"name":"Hirayama Kento"},{"name":"Kowada Minoru"},{"name":"新谷 晃理"},{"name":"福原 弥生"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Ozaki Keisuke"},{"name":"Tsuda Megumi"},{"name":"布川 朋也"},{"name":"中逵 弘能"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"Low TLR4 expression was correlated with tumor progression.","ja":"Low TLR4 expression was correlated with tumor progression."},"publication_date":"2019-02","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.39","number":"No.2","starting_page":"703","ending_page":"711","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/anticanres.13166"],"issn":["1791-7530"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115193","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390564238108124416/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=371082","label":"url"}],"paper_title":{"en":"腎摘除術, 副腎摘除術における血管処理のポイント","ja":"腎摘除術, 副腎摘除術における血管処理のポイント"},"authors":{"en":[{"name":"Kusuhara Yoshito"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"楠原 義人"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"
腹腔鏡下腎摘除術や副腎摘除術は, 簡便な低侵襲手術として標準化され普及している. 本項では, 腎茎の血管処理を安全に遂行するための術前準備, 血管処理の基本について述べた. 術前に血管走行などの作図を行い, 手術手順を確認する準備が重要である. 術前に把握されていない構造物に遭遇した際には, 手技を中断し, 画像を見直すことで安全に手術を遂行できる. また, 手術後に手術動画を省みることで, 画像読影力や作図能力は向上していく.
血管処理は, 「血管以外の組織を凝固切離した結果, 血管だけが残った」という考えで, 丁寧に基本に忠実に行う. 助手の術野展開と鏡の選定を行い, 処理に適した角度から良好な視野を得る. 血管は把持せず, 血管に垂直に鉗子を動かし剥離を行う. 微量な出血も放置せず, その都度止血し無血野を保つ. 各種デバイスの特性を理解し, 処理に最適なデバイスを選択する.
","ja":"腹腔鏡下腎摘除術や副腎摘除術は, 簡便な低侵襲手術として標準化され普及している. 本項では, 腎茎の血管処理を安全に遂行するための術前準備, 血管処理の基本について述べた. 術前に血管走行などの作図を行い, 手術手順を確認する準備が重要である. 術前に把握されていない構造物に遭遇した際には, 手技を中断し, 画像を見直すことで安全に手術を遂行できる. また, 手術後に手術動画を省みることで, 画像読影力や作図能力は向上していく.
血管処理は, 「血管以外の組織を凝固切離した結果, 血管だけが残った」という考えで, 丁寧に基本に忠実に行う. 助手の術野展開と鏡の選定を行い, 処理に適した角度から良好な視野を得る. 血管は把持せず, 血管に垂直に鉗子を動かし剥離を行う. 微量な出血も放置せず, その都度止血し無血野を保つ. 各種デバイスの特性を理解し, 処理に最適なデバイスを選択する.
"},"publication_date":"2019","publication_name":{"en":"Japanese Journal of Endourology","ja":"Japanese Journal of Endourology"},"volume":"Vol.32","number":"No.1","starting_page":"62","ending_page":"65","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.11302/jsejje.32.62"],"issn":["2186-1889"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30064160","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=355368","label":"url"}],"paper_title":{"en":"[Renal Angiomyolipoma Extending into the Renal Vein --A Case Report-].","ja":"腎静脈への進展を認めた腎血管筋脂肪腫の1例"},"authors":{"en":[{"name":"Shimochi Satoru"},{"name":"Daizumoto Kei"},{"name":"Ozaki Keisuke"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"下地 覚"},{"name":"大豆本 圭"},{"name":"尾﨑 啓介"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"We report a case of left renal angiomyolipoma extending into the renal vein. A 67-year-old woman showed a left renal tumor which was 6 cm in diameter and had density equal to fat tissue in computed tomography. We suspected liposarcoma and performed radical nephrectomy and resection of thrombus. The pathological diagnosis was angiomyolipoma with no malignancy. To our knowledge, renal angiomyolipoma with tumor thrombus has been reported in 62 cases, and pulmonary embolism developed in 9 of these cases. We conclude that surgical treatment is effective in treating angiomyolipoma with tumor thrombus.","ja":"We report a case of left renal angiomyolipoma extending into the renal vein. A 67-year-old woman showed a left renal tumor which was 6 cm in diameter and had density equal to fat tissue in computed tomography. We suspected liposarcoma and performed radical nephrectomy and resection of thrombus. The pathological diagnosis was angiomyolipoma with no malignancy. To our knowledge, renal angiomyolipoma with tumor thrombus has been reported in 62 cases, and pulmonary embolism developed in 9 of these cases. We conclude that surgical treatment is effective in treating angiomyolipoma with tumor thrombus."},"publication_date":"2018-05","publication_name":{"en":"Acta Urologica Japonica","ja":"泌尿器科紀要"},"volume":"Vol.64","number":"No.5","starting_page":"213","ending_page":"217","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.14989/ActaUrolJap_64_5_213"],"issn":["0018-1994"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113626","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28652453","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85028539877&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=330611","label":"url"}],"paper_title":{"en":"Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer","ja":"Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer"},"authors":{"en":[{"name":"Mori Hidehisa"},{"name":"Fukumori Tomoharu"},{"name":"DAIZUMOTO KEI"},{"name":"TSUDA MEGUMI"},{"name":"Kusuhara Yoshito"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kubo Akiko"},{"name":"Kawanaka Takashi"},{"name":"Furutani Shunsuke"},{"name":"Ikushima Hitoshi"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"森 英恭"},{"name":"福森 知治"},{"name":"大豆本 圭"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"久保 亜貴子"},{"name":"川中 崇"},{"name":"古谷 俊介"},{"name":"生島 仁史"},{"name":"金山 博臣"}]},"description":{"en":"We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder. Four hundred and four patients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution. In cases with prostate volume more than 30 cm, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution. Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder.","ja":"We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder. Four hundred and four patients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution. In cases with prostate volume more than 30 cm, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution. Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder."},"publication_date":"2017-07","publication_name":{"en":"In Vivo","ja":"In Vivo"},"volume":"Vol.31","number":"No.4","starting_page":"755","ending_page":"761","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/invivo.11127"],"issn":["1791-7549"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/110112","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28013036","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85009932260&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=343834","label":"url"}],"paper_title":{"en":"The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells.","ja":"The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells."},"authors":{"en":[{"name":"Shintani Terumichi"},{"name":"Kusuhara Yoshito"},{"name":"Daizumoto Kei"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Yamamoto Yasuyo"},{"name":"Mori Hidehisa"},{"name":"Fukawa Tomoya"},{"name":"Nakatsuji Hiroyoshi"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"Shintani Terumichi"},{"name":"楠原 義人"},{"name":"Daizumoto Kei"},{"name":"Dondoo Tsogt-Ochir"},{"name":"山本 恭代"},{"name":"森 英恭"},{"name":"布川 朋也"},{"name":"中逵 弘能"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"To clarify the invasive mechanisms of muscle-invasive bladder cancer (BCa) would be useful for the determination of appropriate treatment strategies. We previously showed that hepatocyte growth factor (HGF)-MET signaling is correlated with invasiveness of BCa cells. Here, we investigated the effects of the MET inhibitor, cabozantinib (XL184), on BCa cells. We first conducted Western blot analysis to investigate MET expression in BCa cell lines. Next, we examined the effect of cabozantinib on their proliferation and invasive abilities using MTT and Matrigel invasion assays, respectively. Invasion assays were performed using the xCELLigence system. Additionally, to investigate the biological function of HGF-MET signaling, we analyzed gene expression profiles and performed real-time polymerase chain reaction analyses of 5637 cells that were cultivated with or without HGF stimulation, with or without cabozantinib. MET was highly expressed in 4 of 5 BCa cell lines, and 5637 and T24 cells showed especially high protein expression of MET. Cabozantinib suppressed cell proliferation and invasion (cell index; mock, 1.49 vs HGF, 2.26 vs HGF + XL184, 1.47, P < .05). Gene expression profile analysis indicated that matrix metalloproteinase 1 (MMP1) was significantly elevated at the mRNA level with addition of HGF. Moreover, cabozantinib suppressed HGF-induced MMP1 expression in 5637 T24 cells. These data indicate that cabozantinib suppressed MMP1 expression by blocking HGF-MET signaling and that HGF-MET-MMP1 signaling is involved in the invasiveness and proliferation of BCa cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa.","ja":"To clarify the invasive mechanisms of muscle-invasive bladder cancer (BCa) would be useful for the determination of appropriate treatment strategies. We previously showed that hepatocyte growth factor (HGF)-MET signaling is correlated with invasiveness of BCa cells. Here, we investigated the effects of the MET inhibitor, cabozantinib (XL184), on BCa cells. We first conducted Western blot analysis to investigate MET expression in BCa cell lines. Next, we examined the effect of cabozantinib on their proliferation and invasive abilities using MTT and Matrigel invasion assays, respectively. Invasion assays were performed using the xCELLigence system. Additionally, to investigate the biological function of HGF-MET signaling, we analyzed gene expression profiles and performed real-time polymerase chain reaction analyses of 5637 cells that were cultivated with or without HGF stimulation, with or without cabozantinib. MET was highly expressed in 4 of 5 BCa cell lines, and 5637 and T24 cells showed especially high protein expression of MET. Cabozantinib suppressed cell proliferation and invasion (cell index; mock, 1.49 vs HGF, 2.26 vs HGF + XL184, 1.47, P < .05). Gene expression profile analysis indicated that matrix metalloproteinase 1 (MMP1) was significantly elevated at the mRNA level with addition of HGF. Moreover, cabozantinib suppressed HGF-induced MMP1 expression in 5637 T24 cells. These data indicate that cabozantinib suppressed MMP1 expression by blocking HGF-MET signaling and that HGF-MET-MMP1 signaling is involved in the invasiveness and proliferation of BCa cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa."},"publication_date":"2017-03","publication_name":{"en":"Urology","ja":"Urology"},"volume":"Vol.101","starting_page":"169.e7","ending_page":"169.e13","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.urology.2016.12.006"],"issn":["1527-9995"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26461847","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=315995","label":"url"}],"paper_title":{"en":"Clinical Significance of Neoadjuvant Combined Androgen Blockade for More Than Six Months in Patients with Localized Prostate Cancer Treated with Prostate Brachytherapy.","ja":"Clinical Significance of Neoadjuvant Combined Androgen Blockade for More Than Six Months in Patients with Localized Prostate Cancer Treated with Prostate Brachytherapy."},"authors":{"en":[{"name":"Senzaki Tomokazu"},{"name":"Fukumori Tomoharu"},{"name":"Mori Hidehisa"},{"name":"Kusuhara Yoshito"},{"name":"Komori Masatsugu"},{"name":"Kagawa Junichiro"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Takahashi Masayuki"},{"name":"Kubo Akiko"},{"name":"Kawanaka Takashi"},{"name":"Furutani Shunsuke"},{"name":"Ikushima Hitoshi"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"仙崎 智一"},{"name":"福森 知治"},{"name":"森 英恭"},{"name":"楠原 義人"},{"name":"小森 政嗣"},{"name":"Kagawa Junichiro"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"高橋 正幸"},{"name":"久保 亜貴子"},{"name":"川中 崇"},{"name":"古谷 俊介"},{"name":"生島 仁史"},{"name":"金山 博臣"}]},"description":{"en":"The aim of this study is to clarify the clinical significance of neoadjuvant combined androgen blockade (CAB) for ≥ 6 months in patients with localized prostate cancer. A total of 431 patients with localized prostate cancer who underwent prostate brachytherapy (BT) with or without neoadjuvant CAB for ≥ 6 months with mean follow-up time of 64.6 months (range 24-108 months) were evaluated retrospectively. Of those 431, 232 patients received BT in combination with neoadjuvant CAB for ≥ 6 months. Biochemical recurrence-free rates (BRFRs) in 364 patients with at least 3 years of follow-up were evaluated by log-rank test. BRFR in patients with low-, intermediate- and high-risk prostate cancer were 98.1, 94.2 and 89.1%, respectively. In patients with intermediate-risk prostate cancer only, neoadjuvant CAB was significantly associated with BRFR (p = 0.0468). Especially in patients with intermediate-risk prostate cancer with radiation dose received by 90% of the prostate (D90) < 180 Gy, neoadjuvant CAB exerted a favorable impact on BRFR (p = 0.0429). On multivariate analyses, neoadjuvant CAB and D90 were independent predictors of BRFR (p = 0.0061 and p < 0.0001, respectively). Neoadjuvant CAB for ≥ 6 months has a favorable impact on BRFR in patients with intermediate-risk prostate cancer, particularly in patients with relatively low radiation doses of D90.","ja":"The aim of this study is to clarify the clinical significance of neoadjuvant combined androgen blockade (CAB) for ≥ 6 months in patients with localized prostate cancer. A total of 431 patients with localized prostate cancer who underwent prostate brachytherapy (BT) with or without neoadjuvant CAB for ≥ 6 months with mean follow-up time of 64.6 months (range 24-108 months) were evaluated retrospectively. Of those 431, 232 patients received BT in combination with neoadjuvant CAB for ≥ 6 months. Biochemical recurrence-free rates (BRFRs) in 364 patients with at least 3 years of follow-up were evaluated by log-rank test. BRFR in patients with low-, intermediate- and high-risk prostate cancer were 98.1, 94.2 and 89.1%, respectively. In patients with intermediate-risk prostate cancer only, neoadjuvant CAB was significantly associated with BRFR (p = 0.0468). Especially in patients with intermediate-risk prostate cancer with radiation dose received by 90% of the prostate (D90) < 180 Gy, neoadjuvant CAB exerted a favorable impact on BRFR (p = 0.0429). On multivariate analyses, neoadjuvant CAB and D90 were independent predictors of BRFR (p = 0.0061 and p < 0.0001, respectively). Neoadjuvant CAB for ≥ 6 months has a favorable impact on BRFR in patients with intermediate-risk prostate cancer, particularly in patients with relatively low radiation doses of D90."},"publication_date":"2015-10-14","publication_name":{"en":"Urologia Internationalis","ja":"Urologia Internationalis"},"volume":"Vol.95","number":"No.4","starting_page":"457","ending_page":"464","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000439573"],"issn":["1423-0399"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25770768","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84936985299&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=315994","label":"url"}],"paper_title":{"en":"Long-Term Administration of Docetaxel Over 70 Cycles for Castration-Resistant Prostate Cancer.","ja":"Long-Term Administration of Docetaxel Over 70 Cycles for Castration-Resistant Prostate Cancer."},"authors":{"en":[{"name":"Takahashi Masayuki"},{"name":"Kusuhara Yoshito"},{"name":"Mori Hidehisa"},{"name":"Komori Masatsugu"},{"name":"Kagawa Junichiro"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Fukumori Tomoharu"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"高橋 正幸"},{"name":"楠原 義人"},{"name":"森 英恭"},{"name":"小森 政嗣"},{"name":"Kagawa Junichiro"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"福森 知治"},{"name":"金山 博臣"}]},"publication_date":"2015-01-30","publication_name":{"en":"Clinical Genitourinary Cancer","ja":"Clinical Genitourinary Cancer"},"volume":"Vol.13","number":"No.4","starting_page":"e337","ending_page":"40","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.clgc.2015.01.012"],"issn":["1938-0682"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000303005","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=302596","label":"url"}],"paper_title":{"en":"徳島大学泌尿器科におけるBCG膀胱内注入療法の臨床検討","ja":"徳島大学泌尿器科におけるBCG膀胱内注入療法の臨床検討"},"authors":{"en":[{"name":"井内 俊輔"},{"name":"Mori Hidehisa"},{"name":"大豆本 圭"},{"name":"津田 恵"},{"name":"Kusuhara Yoshito"},{"name":"Kagawa Jun-ichiro"},{"name":"Fukawa Tomoya"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"井内 俊輔"},{"name":"森 英恭"},{"name":"大豆本 圭"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"香川 純一郎"},{"name":"布川 朋也"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"publication_date":"2015-03","publication_name":{"en":"泌尿器外科","ja":"泌尿器外科"},"volume":"Vol.28","number":"No.3","starting_page":"330","ending_page":"331","languages":["jpn"],"published_paper_type":"research_institution"}}