type: misc

label: url

en: 低酸素を標的とした抗転移剤による化学放射線療法の可能性

ja: 低酸素を標的とした抗転移剤による化学放射線療法の可能性

en: Radiation Biology Research Communications

ja: 放射線生物研究


en: 生体内代謝プロセスの多重共鳴 NMR モニタリングと多重共鳴 MRI に展開可能な高感度化分子プローブの開発

en: 公益社団法人 日本化学会 生体機能関連化学部会 ニュースレター

ja: 公益社団法人 日本化学会 生体機能関連化学部会 ニュースレター


en: Rhodol骨格に基づく新規低酸素環境認識プローブの開発とバイオイメージングへの応用

en: 日本分析化学会第58年会 展望とトピックス

ja: 日本分析化学会第58年会 展望とトピックス


en: Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.

en: 5-Fluorouracil (5-FU) is used widely as an anticancer drug to treat solid cancers, such as colon, breast, rectal, and pancreatic cancers, although its clinical application is limited because 5-FU has gastrointestinal and hematological toxicity. Many groups are searching for prodrugs with functions that are tumor selective in their delivery and can be activated to improve the clinical utility of 5-FU as an important cancer chemotherapeutic agent. UV and ionizing radiation can cause chemical reactions in a localized area of the body, and these have been applied in the development of site-specific drug activation and sensitization. In this review, we describe recent progress in the development of novel 5-FU prodrugs that are activated site specifically by UV light and ionizing radiation in the tumor microenvironment. We also discuss the chemical mechanisms underlying this activation.

en: Molecules

ja: Molecules