{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2012788","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38672461","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410682","label":"url"}],"paper_title":{"en":"Emerging Insights into the Role of BDNF on Health and Disease in Periphery.","ja":"Emerging Insights into the Role of BDNF on Health and Disease in Periphery."},"authors":{"en":[{"name":"Shimizu Mayuko"},{"name":"Kurrey Khuleshwari"},{"name":"Miyata Misaki"},{"name":"Dezawa Takuya"},{"name":"Tsuneyama Koichi"},{"name":"Kojima Masami"}],"ja":[{"name":"清水 真祐子"},{"name":"Kurrey Khuleshwari"},{"name":"Miyata Misaki"},{"name":"Dezawa Takuya"},{"name":"常山 幸一"},{"name":"Kojima Masami"}]},"description":{"en":"Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain.","ja":"Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain."},"publication_date":"2024-04-05","publication_name":{"en":"Biomolecules","ja":"Biomolecules"},"volume":"14","number":"4","languages":["eng"],"identifiers":{"doi":["10.3390/biom14040444"],"issn":["2218-273X"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/031726800","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1521980706163941632/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382593","label":"url"}],"paper_title":{"en":"Gastrointestinal microbiome and non-alcoholic steatohepatitis","ja":"非アルコール性脂肪肝炎(NASH)と腸内細菌"},"authors":{"en":[{"name":"菊池 健太郎"},{"name":"松本 光太郎"},{"name":"高井 敦子"},{"name":"Shimizu Mayuko"},{"name":"守時 由起"},{"name":"Tsuneyama Koichi"},{"name":"原 眞純"},{"name":"宮川 浩"}],"ja":[{"name":"菊池 健太郎"},{"name":"松本 光太郎"},{"name":"高井 敦子"},{"name":"清水 真祐子"},{"name":"守時 由起"},{"name":"常山 幸一"},{"name":"原 眞純"},{"name":"宮川 浩"}]},"publication_date":"2021-09","publication_name":{"en":"Diabetology, Endocrinology & Metabolology","ja":"糖尿病·内分泌代謝科"},"volume":"53","number":"3","starting_page":"356","ending_page":"360","languages":["jpn"],"identifiers":{"issn":["2435-1946"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://ci.nii.ac.jp/naid/120006860007/","label":"url"},{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2007784","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050867133850762240/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=367191","label":"url"}],"paper_title":{"en":"Progress of Artificial Intelligence and Molecular Pathology","ja":"AIと分子病理学の新展開"},"authors":{"en":[{"name":"Tsuneyama Koichi"},{"name":"Morimoto Yuki"},{"name":"Kaji Shoma"},{"name":"Oya Takeshi"}],"ja":[{"name":"常山 幸一"},{"name":"森本 友樹"},{"name":"加地 将真"},{"name":"尾矢 剛志"}]},"description":{"en":"A pathological diagnosis that incorporates a molecular biology technique into a conventional pathological diagnosis based on morphology is called a molecular pathological diagnosis. Immunostaining, which detects proteins derived from oncogenes and tumor suppressor genes with specific antibodies, and FISH, which uses a fluorescently labeled nucleic acid probe to examine the amplification of a target gene, are already in clinical practice. In recent years, the application of genome analysis using a next-generation sequencer to pathological diagnosis has become available, and cancer genomic medicine has been rapidly expanding and evolving. In addition, new technologies such as liquid biopsy technology that detects proteins, DNA, microRNA, methylated DNA, etc. from samples that are less invasive at the time of collection, such as blood, are being incorporated into pathological diagnosis. The application of artificial intelligence(AI)is being studied around the world to reflect the diagnosis. This article introduces the application of rapid mass spectrometry(PESI-MS)to liquid biopsy and the development of diagnostic aids for urine cytology using AI.","ja":"A pathological diagnosis that incorporates a molecular biology technique into a conventional pathological diagnosis based on morphology is called a molecular pathological diagnosis. Immunostaining, which detects proteins derived from oncogenes and tumor suppressor genes with specific antibodies, and FISH, which uses a fluorescently labeled nucleic acid probe to examine the amplification of a target gene, are already in clinical practice. In recent years, the application of genome analysis using a next-generation sequencer to pathological diagnosis has become available, and cancer genomic medicine has been rapidly expanding and evolving. In addition, new technologies such as liquid biopsy technology that detects proteins, DNA, microRNA, methylated DNA, etc. from samples that are less invasive at the time of collection, such as blood, are being incorporated into pathological diagnosis. The application of artificial intelligence(AI)is being studied around the world to reflect the diagnosis. This article introduces the application of rapid mass spectrometry(PESI-MS)to liquid biopsy and the development of diagnostic aids for urine cytology using AI."},"publication_date":"2020-04-25","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"76","number":"1,2","starting_page":"23","ending_page":"28","languages":["jpn"],"identifiers":{"issn":["0037-3699"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
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{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=367186","label":"url"}],"paper_title":{"en":"【自己免疫性肝疾患-自己免疫性肝炎，原発性胆汁性胆管炎，原発性硬化性胆管炎-】発症機序，病理 自己免疫性肝炎 自己免疫性肝炎の病理(解説/特集)","ja":"【自己免疫性肝疾患-自己免疫性肝炎，原発性胆汁性胆管炎，原発性硬化性胆管炎-】発症機序，病理 自己免疫性肝炎 自己免疫性肝炎の病理(解説/特集)"},"authors":{"en":[{"name":"Tsuneyama Koichi"},{"name":"Oya Takeshi"},{"name":"Ogawa Hirohisa"},{"name":"Matsumoto Minoru"},{"name":"Satake Nobuo"}],"ja":[{"name":"常山 幸一"},{"name":"尾矢 剛志"},{"name":"小川 博久"},{"name":"松本 穣"},{"name":"佐竹 宣法"}]},"publication_date":"2020-01-01","publication_name":{"en":"Nihon Rinsho. Japanese Journal of Clinical Medicine","ja":"日本臨牀"},"volume":"78","number":"1","starting_page":"65","ending_page":"70","languages":["jpn"],"identifiers":{"issn":["0047-1852"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=362749","label":"url"}],"paper_title":{"en":"肝臓病理所見のとり方とその解釈","ja":"肝臓病理所見のとり方とその解釈"},"authors":{"en":[{"name":"Tsuneyama Koichi"},{"name":"Shimizu Mayuko"},{"name":"Oya Takeshi"},{"name":"Matsumoto Minoru"},{"name":"Kobayashi Tomoko"},{"name":"Ogawa Hirohisa"},{"name":"Nishitsuji Kazuchika"},{"name":"Yamashita Michiko"}],"ja":[{"name":"常山 幸一"},{"name":"清水 真祐子"},{"name":"尾矢 剛志"},{"name":"松本 穣"},{"name":"小林 智子"},{"name":"小川 博久"},{"name":"西辻 和親"},{"name":"山下 理子"}]},"publication_date":"2019-07","publication_name":{"en":"法医病理","ja":"法医病理"},"volume":"25","number":"1","starting_page":"1","ending_page":"12","languages":["jpn"],"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=349706","label":"url"}],"paper_title":{"en":"AIRE - The Autoimmune Regulator","ja":"AIRE - The Autoimmune Regulator"},"authors":{"en":[{"name":"Matsumoto Minoru"},{"name":"Nishijima Hitoshi"},{"name":"Morimoto Junko"},{"name":"Tsuneyama Koichi"},{"name":"Matsumoto Mitsuru"}],"ja":[{"name":"Matsumoto Minoru"},{"name":"西嶋 仁"},{"name":"森本 純子"},{"name":"常山 幸一"},{"name":"松本 満"}]},"publication_date":"2019-02-15","publication_name":{"en":"eLS","ja":"eLS"},"languages":["eng"],"identifiers":{"doi":["10.1002/9780470015902.a0027281"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=333663","label":"url"}],"paper_title":{"en":"非アルコール性脂肪性肝障害(NAFLD)/肝炎(NASH)の肝生検診断の注意点","ja":"非アルコール性脂肪性肝障害(NAFLD)/肝炎(NASH)の肝生検診断の注意点"},"authors":{"en":[{"name":"Tsuneyama Koichi"}],"ja":[{"name":"常山 幸一"}]},"publication_date":"2017-07","publication_name":{"en":"診断病理","ja":"診断病理"},"volume":"34","number":"3","starting_page":"143","ending_page":"151","languages":["jpn"],"invited":true,"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/120005851763/","label":"url"},{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2003163","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050867133853288960/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=307054","label":"url"}],"paper_title":{"en":"New animal models for the translational study of metabolic syndrome-associated liver diseases","ja":"メタボリックシンドローム関連肝疾患モデル動物の開発と応用 ~ヒト病態解析への疾患病理学的アプローチ~"},"authors":{"en":[{"name":"Tsuneyama Koichi"}],"ja":[{"name":"常山 幸一"}]},"description":{"en":"Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). NASH is known to extend into liver cirrhosis and hepatocellular carcinoma (HCC). To determine the pathogenesis and effective treatment, an excellent animal model of NASH/HCC is required. We recently succeeded to develop two MS associated NASH mice model (TSOD mice and DIAR-MSG mice). Their clinical course and pathological characters were quite similar to those of human MS-NASH patients. Interestingly, most of them developed HCC in aged,which pathological and functional characters were identical to those of human HCC. In addition, we established a novel mouse model of HCC based on type 1 diabetes (DIAR-nSTZ mice) and reported its histopathological features. To compare these mice models from various aspects, we can highlight specific and useful characters of MS associated liver diseases including hepatocarcinogenesis.","ja":"Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). NASH is known to extend into liver cirrhosis and hepatocellular carcinoma (HCC). To determine the pathogenesis and effective treatment, an excellent animal model of NASH/HCC is required. We recently succeeded to develop two MS associated NASH mice model (TSOD mice and DIAR-MSG mice). Their clinical course and pathological characters were quite similar to those of human MS-NASH patients. Interestingly, most of them developed HCC in aged,which pathological and functional characters were identical to those of human HCC. In addition, we established a novel mouse model of HCC based on type 1 diabetes (DIAR-nSTZ mice) and reported its histopathological features. To compare these mice models from various aspects, we can highlight specific and useful characters of MS associated liver diseases including hepatocarcinogenesis."},"publication_date":"2015-12-25","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"71","number":"5,6","starting_page":"113","ending_page":"120","languages":["jpn"],"identifiers":{"issn":["0037-3699"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000044183","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=307055","label":"url"}],"paper_title":{"en":"原発性胆汁性肝硬変の免疫病理","ja":"原発性胆汁性肝硬変の免疫病理"},"authors":{"en":[{"name":"佐々塚 涼弥"},{"name":"馬場 逸人"},{"name":"菊池 健太郎"},{"name":"守時 由起"},{"name":"Tsuneyama Koichi"}],"ja":[{"name":"佐々塚 涼弥"},{"name":"馬場 逸人"},{"name":"菊池 健太郎"},{"name":"守時 由起"},{"name":"常山 幸一"}]},"publication_date":"2015-11","publication_name":{"en":"肝胆膵","ja":"肝胆膵"},"volume":"71","number":"5","starting_page":"831","ending_page":"837","languages":["jpn"],"misc_type":"introduction_scientific_journal"},"priority":"input_data"}