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en: Emerging Insights into the Role of BDNF on Health and Disease in Periphery.

en: Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain.

en: Biomolecules

ja: Biomolecules


en: Gastrointestinal microbiome and non-alcoholic steatohepatitis

ja: 非アルコール性脂肪肝炎(NASH)と腸内細菌

en: Diabetology, Endocrinology & Metabolology

ja: 糖尿病·内分泌代謝科


en: Progress of Artificial Intelligence and Molecular Pathology

ja: AIと分子病理学の新展開

en: A pathological diagnosis that incorporates a molecular biology technique into a conventional pathological diagnosis based on morphology is called a molecular pathological diagnosis. Immunostaining, which detects proteins derived from oncogenes and tumor suppressor genes with specific antibodies, and FISH, which uses a fluorescently labeled nucleic acid probe to examine the amplification of a target gene, are already in clinical practice. In recent years, the application of genome analysis using a next-generation sequencer to pathological diagnosis has become available, and cancer genomic medicine has been rapidly expanding and evolving. In addition, new technologies such as liquid biopsy technology that detects proteins, DNA, microRNA, methylated DNA, etc. from samples that are less invasive at the time of collection, such as blood, are being incorporated into pathological diagnosis. The application of artificial intelligence(AI)is being studied around the world to reflect the diagnosis. This article introduces the application of rapid mass spectrometry(PESI-MS)to liquid biopsy and the development of diagnostic aids for urine cytology using AI.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: 【肝細胞性腫瘍の分類・亜分類の最前線】肝細胞腺腫 肝細胞腺腫の分類と分子生物学的成り立ち(解説/特集)

en: KAN TAN SUI

ja: 肝·胆·膵


en: 【自己免疫性肝疾患-自己免疫性肝炎，原発性胆汁性胆管炎，原発性硬化性胆管炎-】発症機序，病理 自己免疫性肝炎 自己免疫性肝炎の病理(解説/特集)

en: Nihon Rinsho. Japanese Journal of Clinical Medicine

ja: 日本臨牀


en: 肝臓病理所見のとり方とその解釈

ja: 肝臓病理所見のとり方とその解釈

en: 法医病理

ja: 法医病理


en: AIRE - The Autoimmune Regulator

ja: AIRE - The Autoimmune Regulator

en: eLS

ja: eLS


en: 非アルコール性脂肪性肝障害(NAFLD)/肝炎(NASH)の肝生検診断の注意点

ja: 非アルコール性脂肪性肝障害(NAFLD)/肝炎(NASH)の肝生検診断の注意点

en: 診断病理

ja: 診断病理


en: New animal models for the translational study of metabolic syndrome-associated liver diseases

ja: メタボリックシンドローム関連肝疾患モデル動物の開発と応用 ~ヒト病態解析への疾患病理学的アプローチ~

en: Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). NASH is known to extend into liver cirrhosis and hepatocellular carcinoma (HCC). To determine the pathogenesis and effective treatment, an excellent animal model of NASH/HCC is required. We recently succeeded to develop two MS associated NASH mice model (TSOD mice and DIAR-MSG mice). Their clinical course and pathological characters were quite similar to those of human MS-NASH patients. Interestingly, most of them developed HCC in aged,which pathological and functional characters were identical to those of human HCC. In addition, we established a novel mouse model of HCC based on type 1 diabetes (DIAR-nSTZ mice) and reported its histopathological features. To compare these mice models from various aspects, we can highlight specific and useful characters of MS associated liver diseases including hepatocarcinogenesis.


en: 原発性胆汁性肝硬変の免疫病理

ja: 原発性胆汁性肝硬変の免疫病理

en: 肝胆膵

ja: 肝胆膵