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Research Activity

Field of Study

Immunology

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.Kunihiro Otsuka, Akiko Yamada, Masako Saito, Aya Ushio, Mami Sato, Satoru Kisoda, Wenhua Shao, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
Ascl2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren's Syndrome.,
The American Journal of Pathology, 2019.
(DOI: 10.1016/j.ajpath.2019.08.008,   PubMed: 31539517)
2.Kunihiro Ohtsuka, Kohichi Yamada, Yuhji Taquahashi, Rieko Arakaki, Aya Ushio, Masako Saito, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jun Kanno and Naozumi Ishimaru :
Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes.,
PLoS ONE, Vol.13, No.10, e0205702., 2018.
(Tokushima University Institutional Repository: 113371,   DOI: 10.1371/journal.pone.0205702,   PubMed: 30372450,   Elsevier: Scopus)
3.Yuji Fujita, Kiyoshi Masuda, Junichi Hamada, Katsutoshi Shoda, Takuya Naruto, Satoshi Hamada, Yuko Miyakami, Tomohiro Kohmoto, Miki Watanabe, Rizu Takahashi, Shoichiro Tange, Masako Saito, Yasusei Kudo, Hitoshi Fujiwara, Daisuke Ichikawa, Akira Tangoku, Eigo Otsuji and Issei Imoto :
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression.,
Oncotarget, Vol.8, No.60, 101130-101145, 2017.
(Tokushima University Institutional Repository: 110988,   DOI: 10.18632/oncotarget.20926,   PubMed: 29254151)
4.Tomohiro Kohmoto, Nana Okamoto, Takuya Naruto, Chie Murata, Yuya Ouchi, Naoko Fujita, Hidehito Inagaki, Shigeko Satomura, Nobuhiko Okamoto, Masako Saito, Kiyoshi Masuda, Hiroki Kurahashi and Issei Imoto :
A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements.,
Molecular Cytogenetics, Vol.10, 15, 2017.
(DOI: 10.1186/s13039-017-0316-6,   PubMed: 28465723,   Elsevier: Scopus)
5.Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru and Yasusei Kudo :
Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.,
Oral Oncology, Vol.69, 46-55, 2017.
(Tokushima University Institutional Repository: 111726,   DOI: 10.1016/j.oraloncology.2017.04.003,   PubMed: 28559020)
6.Akiko Yamada, Rieko Arakaki, Masako Saito, Yasusei Kudo and Naozumi Ishimaru :
Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance.,
Frontiers in Immunology, Vol.8, No.403, 2017.
(Tokushima University Institutional Repository: 110975,   DOI: 10.3389/fimmu.2017.00403,   PubMed: 28424702)
7.Nobuhiko Okamoto, Miki Watanabe, Takuya Naruto, Keiko Matsuda, Tomohiro Kohmoto, Masako Saito, Kiyoshi Masuda and Issei Imoto :
Genome-first approach diagnosed Cabezas syndrome via novel CUL4B mutation detection.,
Human Genome Variation, Vol.4, 16045, 2017.
(DOI: 10.1038/hgv.2016.45,   PubMed: 28144446)
8.Yoshiyuki Minegishi and Masako Saito :
Cutaneous Manifestations of Hyper IgE Syndrome.,
Allergology International, Vol.61, No.2, 191-196, 2012.
(DOI: 10.2332/allergolint.12-RAI-0423,   PubMed: 22441639)
9.Yoshiyuki Minegishi and Masako Saito :
Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome.,
Annals of the New York Academy of Sciences, Vol.1246, 34-40, 2011.
(DOI: 10.1111/j.1749-6632.2011.06280.x,   PubMed: 22236428)
10.Masako Saito, Masayuki Nagasawa, Hidetoshi Takada, Toshiro Hara, Shigeru Tsuchiya, Kazunaga Agematsu, Masafumi Yamada, Nobuaki Kawamura, Tadashi Ariga, Ikuya Tsuge, Shigeaki Nonoyama, Hajime Karasuyama and Yoshiyuki Minegishi :
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.,
The Journal of Experimental Medicine, Vol.208, No.2, 235-249, 2011.
(DOI: 10.1084/jem.20100799,   PubMed: 21300911)

Review, Commentary:

1.Masako Saito, Kunihiro Otsuka, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
Unique Phenotypes and Functions of Follicular Helper T Cell and Regulatory T Cell in Sjögren's Syndrome.,
Current Rheumatology Reviews, Vol.14, No.3, 239-245, Jan. 2017.
(DOI: 10.2174/1573397113666170125122858,   PubMed: 28124612)
2.Akiko Yamada, Rieko Arakaki, Masako Saito, Takaaki Tsunematsu, Yasusei Kudo and Naozumi Ishimaru :
Role of regulatory T cell in the pathogenesis of inflammatory bowel disease.,
World Journal of Gastroenterology : WJG, Vol.22, No.7, 2195-2205, Feb. 2016.
(Tokushima University Institutional Repository: 110976,   DOI: 10.3748/wjg.v22.i7.2195,   PubMed: 26900284,   Elsevier: Scopus)

Proceeding of International Conference:

1.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Takaaki Tsunematsu, Rieko Arakaki, Yasusei Kudo, Hidehiro Kishimmoto and Naozumi Ishimaru :
Analysis of follicular helper T cells in a mouse model for Sjogren's Syndorome.,
11th International Congress of Autoimmunity, Lisbon, May 2018.
2.Masako Saito, Kunihiro Ohtsuka, Aya Ushio, Mie Kurosawa, Akiko Yamada, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
Abnormal germinal center(GC)reaction in autoimmunity.,
ICI2016, Melbourne, Aug. 2016.
3.Masako Saito, Karasuyama Hajime and Yoshiyuki Minegishi :
A molecular mechanism underlying atopic dermatitis in hyper-IgE syndrome,
American Academy of Allergy Asthma Immunology, Mar. 2014.
4.Masako Saito, Hajime Karasuyama and Yoshiyuki Minegishi :
A molecular mechanism underlying atopic dermatitis in hyper IgE syndrome,
15th Biennial meeting of the European Society for Immunodeficiencies, Firenze, 2012.

Proceeding of Domestic Conference:

1.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoru Kisoda, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
A crucial role of follicular helper T cells in autoimmunity of a mouse model for Sjogren's syndorome.,
Proceedings of the Japanese Society for Immunology, Dec. 2018.
2.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoru Kisoda, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割,
日本シェーグレン症候群学会, Sep. 2018.
3.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoru Kisoda, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割,
Japanese Journal of Oral Biology, Sep. 2018.
4.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoru Kisoda, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
Asc/2を介した濾胞ヘルパーT細胞分化異常が自己免疫疾患の病態形成に関与する.,
日本臨床口腔病理学会, Aug. 2018.
5.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoru Kisoda, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割,
分子病理学研究会, Jul. 2018.
6.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割,
Proceedings of the Japanese Society of Pathology, Vol.107, Jun. 2018.
7.Shoichiro Tange, Tomohiro Kohmoto, Kiyoshi Masuda, Masako Saito and Issei Imoto :
トリプルネガティブ乳がんと予後予測遺伝子候補CPIG7.2の関連性,
日本分子生物学会年会, Dec. 2017.
8.Masako Saito, Ken-ichi Suga, Takuya Naruto, Tomohiro Kohmoto, Rizu Takahashi, 堀内 圭輔, 中山 寛尚, 東山 繁樹, Ryuji Nakagawa, Masanobu Ootsu, Shoichiro Tange, Kiyoshi Masuda and Shoji Kagami :
Compound heterozygous missense mutations in the ADAM17 gene in patient with neonatal inflammatory skin and bowel disease 1,
日本人類遺伝学会, Nov. 2017.
9.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Satoko Kujiraoka, Mie Kurosawa, Takaaki Tsunematsu, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
シェーグレン症候群疾患モデルにおける胚中心反応の解析,
第28回日本臨床口腔病理学会, Vol.28, Aug. 2017.
10.Rieko Arakaki, Kohichi Yamada, Masako Saito, Kunihiro Ohtsuka, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, 菅野 純 and Naozumi Ishimaru :
Chronic influence of Multi-walled carbon nanotubes (MWCNT) on immune system,
第106回日本病理学会総会, Vol.106, Apr. 2017.
11.Masaaki Umeda, Takaaki Tsunematsu, Masako Saito, Akiko Yamada, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
口腔癌におけるPeriostinスプライシングバリアントの新たな役割,
第106回日本病理学会総会, Vol.106, Apr. 2017.
12.Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Aya Ushio, Mie Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群モデルマウスにおける濾胞ヘルパーT細胞の解析,
第106回日本病理学会総会, Vol.106, Apr. 2017.
13.Rieko Arakaki, Kohichi Yamada, Aya Ushio, Mie Kurosawa, Kunihiro Ohtsuka, Masako Saito, Takaaki Tsunematsu, Akiko Yamada, Yasusei Kudo and Naozumi Ishimaru :
Immunological and toxicological effect of multi-wall carbon nanotubes by whole body inhalation exposure in B6 mice,
第45回日本免疫学会学術集会, Vol.45, Dec. 2016.
14.Kunihiro Ohtsuka, Masako Saito, Mie Kurosawa, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
Analysis of follicular helper T cells in a mouse model for Sjogren's syndrome.,
第45回日本免疫学会学術集会, Vol.45, Dec. 2016.
15.Aya Ushio, Rieko Arakaki, Masako Saito, Akiko Yamada, Kunihiro Ohtsuka, Mie Kurosawa, Satoko Kujiraoka, Yasusei Kudo and Naozumi Ishimaru :
Analysis of macrophages in the pathogenesis of a murine model for Sjogren's syndrome.,
第45回日本免疫学会学術集会, Vol.45, Dec. 2016.
16.Aya Ushio, Rieko Arakaki, Kunihiro Ohtsuka, Masako Saito, Akiko Yamada, Yasusei Kudo and Naozumi Ishimaru :
シェーグレン症候群の病態形成におけるマクロファージの役割,
日本シェーグレン症候群学会, Vol.25, Sep. 2016.
17.Kunihiro Ohtsuka, Masako Saito, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
シェーグレン症候群モデルにおける濾胞ヘルパーT細胞の機能解析,
日本シェーグレン症候群学会, Vol.25, Sep. 2016.
18.Masaaki Umeda, Takaaki Tsunematsu, Masako Saito, Akiko Yamada, Rieko Arakaki, Yasusei Kudo and Naozumi Ishimaru :
口腔扁平上皮癌におけるPeriostinスプライシングバリアントの新たな役割,
第27回日本臨床口腔病理学会総会・学術大会, Aug. 2016.
19.Rieko Arakaki, Takaaki Tsunematsu, Akiko Yamada, Masako Saito, Yasusei Kudo and Naozumi Ishimaru :
全身吸入暴露による多層化カーボンナノチューブの免疫システムへの影響,
第105回日本病理学会総会, Vol.105, No.1, May 2016.
20.Aya Ushio, Masako Saito, Akiko Yamada, Kunihiro Ohtsuka, Mie Kurosawa, Satoko Kujiraoka, Yasusei Kudo and Naozumi Ishimaru :
シェーグレン症候群モデルマウスの病態形成におけるマクロファージの役割,
第105回日本病理学会総会, Vol.105, No.1, May 2016.
21.Masako Saito, Rieko Arakaki, Kunihiro Ohtsuka, Kohichi Yamada, Yasusei Kudo and Naozumi Ishimaru :
Biological effect of Multi-Walled Carbon Nanotubes(MWCNTs)on imune system.,
Proceedings of the Japanese Society for Immunology, Nov. 2015.
22.Rieko Arakaki, Aya Ushio, Mie Kurosawa, Kunihiro Ohtsuka, Akiko Yamada, Masako Saito, Takaaki Tsunematsu, Yasusei Kudo and Naozumi Ishimaru :
Analysis of function of macrophages in murine models of Sjogren's syndorome.,
Proceedings of the Japanese Society for Immunology, Nov. 2015.
23.Mie Kurosawa, Akiko Yamada, Rieko Arakaki, Masako Saito, Takaaki Tsunematsu, Yasusei Kudo and Naozumi Ishimaru :
Migratory activity of memory T cells in aly/aly mice.,
Proceedings of the Japanese Society for Immunology, Nov. 2015.
24.Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
Analysis of the mechanisms of the susceptibility to staphylococcal infection in a mouse model of Hyper-IgE syndrome,
The 43rd Annual Meeting of The Japanease Society for Immunology, Dec. 2014.

Et cetera, Workshop:

1.Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
高IgE症候群モデルマウスのマスト細胞の機能解析,
感染・免疫クラスターリトリート, Oct. 2014.
2.Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
高IgE症候群モデルマウスでの黄色ブドウ球菌に対する易感染性の病態,
第13回四国免疫フォーラム, Jun. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 発熱と脂肪織炎を特徴とする新規自己炎症性疾患の病態解明研究 (Project/Area Number: 19K08252 )
  • Analysis of Pathogenesis of Autoimmunity through Communication between Organs (Project/Area Number: 19H01070 )
  • 加齢による胚中心応答を介した免疫システム破綻機構の解明 (Project/Area Number: 16K20438 )
  • Analysis of autoimmunity caused by environmental factors~New pathogenesis of autoimmune disease~ (Project/Area Number: 16H02690 )
  • The development of bone marrow transplantation as a treatment for hyper-IgE syndrome (Project/Area Number: 26860807 )
  • Search by Researcher Number (00723892)