irahara_makoto/published_papers/52669675 Kiwako Yamamoto-Hanada Eiryo Kawakami Miori Sato Makoto Irahara Kenji Toyokuni Erika Hiraide-Kotaki Naomi Harima-Mizusawa Norihiro Kubota Hideaki Morita Kenji Matsumoto Tatsuki Fukuie Yukihiro Ohya Interaction Between Lifestyle, Immunity and Gut Microbiota in Milk Allergy Children. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 55 10 960 963 20251000 10.1111/cea.70080 40346839 irahara_makoto/published_papers/52829944 苛原 誠 福家 辰樹 川崎 洋 諫山 純 増田 奏衣 青戸 良賢 森田 英明 松本 健治 吉田 和恵 山本 貴和子 大矢 幸弘 新生児期マイクロバイオームと生後6ヵ月の卵白感作との関連 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 39 4 325 325 20250900 irahara_makoto/published_papers/52783399 苛原 誠 福家 辰樹 川崎 洋 諫山 純 増田 奏衣 青戸 良賢 森田 英明 松本 健治 吉田 和恵 山本 貴和子 大矢 幸弘 新生児期マイクロバイオームと生後6ヵ月の卵白感作との関連 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 39 4 325 325 20250900 irahara_makoto/published_papers/48642028 Shigenori Kabashima Kiwako Hanada Yamamoto Yumiko Miyaji Yuri Endo Kram Mami Shimada Seiko Hirai Hiroya Ogita Tomoyuki Kiguchi Yusuke Inuzuka Kenji Toyokuni Makoto Irahara Fumi Ishikawa Miori Sato Mayako Saito-Abe Hiroki Yasudo Tatsuki Fukuie Ichiro Nomura Audrey DunnGalvin Yukihiro Ohya Japanese version of the food allergy quality of life questionnaire 10: An easy-to-use instrument World Allergy Organization Journal 1939-4551 null null 20241100 10.1016/j.waojou.2024.100979 irahara_makoto/published_papers/47486388 岸野 愛 福家 辰樹 苛原 誠 小笠原 久子 川崎 洋 諫山 純 増田 奏衣 山本 貴和子 斎藤 博久 大矢 幸弘 わが国における新生児期からの乳幼児スキンケアの現状 ハイリスク出生コホート研究 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 37 4 390 390 20231000 irahara_makoto/published_papers/48642024 K. Yamamoto-Hanada M. Sato K. Toyokuni M. Irahara E. Hiraide-Kotaki N. Harima-Mizusawa H. Morita K. Matsumoto Y. Ohya Combination of heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) and oral immunotherapy in cow's milk allergy: a randomised controlled trial <jats:p> Safer and more effective cow milk (CM)-oral immunotherapy that does not induce allergic reactions has not yet been standardised. We sought to explore the efficacy and feasibility of a combination of heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) and oral immunotherapy for treating IgE-mediated cow milk allergy (CMA). We conducted a 24-week, double-blind, randomised (1:1), two-arm, parallel-group, placebo-controlled, phase 2 trial of LP0132 intervention for treating IgE-mediated CMA in children aged 1-18 years (n=60) from January 29, 2018 to July 12, 2019 in Tokyo, Japan. Participants were randomly assigned to the LP0132 group receiving citrus juice fermented with LP0132 or to the control group receiving citrus juice without. Both groups received low-dose slow oral immunotherapy with CM. The primary outcome was improved tolerance to CM, proven by the CM challenge test at 24 weeks. Secondary outcomes were changes in serum biomarkers of serum-specific β-lactoglobulin-IgE (sIgE) and β-lactoglobulin-IgG4 (sIgG4). Exploratory outcomes included changes in serum cytokine levels and gut microbiota composition. A total of 61 participants were included. Finally, 31 children were assigned to the LP0132 group and 30 to the control group, respectively. After the intervention, 41.4 and 37.9% of the participants in the LP0132 and control groups, respectively, showed improved tolerance to CM. In serum biomarkers after the intervention, the sIgG4 level was significantly higher, and interleukin (IL)-5 and IL-9 were significantly lower, in the LP0132 group than in the control group. In the gut microbiome, the α-diversity and Lachnospiraceae increased significantly in the LP0132 group, and Lachnospiraceae after the intervention was significantly higher in the LP0132 group than in the control group. In conclusion, low-dose oral immunotherapy with modulating gut microbiota might be a safer and more effective approach for treating cow's milk allergy. </jats:p> Wageningen Academic Publishers Beneficial Microbes 1876-2883 1 14 20230223 10.3920/bm2022.0064 irahara_makoto/published_papers/41562932 Makoto Irahara Kiwako Yamamoto-Hanada Miori Sato Mayako Saito-Abe Yumiko Miyaji Limin Yang Minaho Nishizato Natsuhiko Kumasaka Hidetoshi Mezawa Yukihiro Ohya Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children's Study Changes in household endotoxin concentration may affect the prognosis of food allergy (FA), but data on the association between household endotoxin concentration and an already-developed FA are scarce. Thus, we investigated the association between environmental endotoxin exposure and tolerance to hen's egg (HE) and cow's milk (CM) using data from children participating in the Japan Environment and Children's Study who had HE allergies (n = 204) and CM allergy (n = 72) in their first year of life. We grouped the endotoxin results into quartiles 1-4 (Q1-Q4). In children with HE allergy and with CM allergy, there was no significant difference in the prevalence of tolerance to HE and CM at 2 years old when comparing endotoxin levels of the children in Q1 with those in Q2, Q3, and Q4, respectively. However, subgroup analyses by the presence of eczema and causal foods revealed that children in Q1 had a lower prevalence of tolerance to foods in some subgroup analyses and lower causal allergen-specific immunoglobulin G4 levels. Although an individually based approach against endotoxin according to background characteristics, such as eczema and causal foods, is necessary, preventing excessive endotoxin removal might contribute to FA resolution in some children. Nutrients 15 4 null null 20230215 10.3390/nu15040968 36839328 irahara_makoto/published_papers/41301377 Fumiko Kumagai Kiwako Yamamoto-Hanada Mayako Saito-Abe Miori Sato Fumi Ishikawa Makoto Irahara Yumiko Miyaji Shigenori Kabashima Yukihiro Ohya Masashi Akiyama Michihiro Kono FLG mutations, Eczema Control, and Respiratory Symptom at One-Year-Old in Early-Onset Atopic Dermatitis Infants (PACI-ON Cohort Study) Elsevier {BV} Journal of Dermatological Science 0923-1811 109 2 99 101 20230124 10.1016/j.jdermsci.2023.01.009 36737282 irahara_makoto/published_papers/41227444 Makoto Irahara Kiwako Yamamoto-Hanada Miori Sato Mayako Saito-Abe Yumiko Miyaji Limin Yang Minaho Nishizato Natsuhiko Kumasaka Hidetohi Mezawa Yukihiro Ohya Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Reiko Kishi Nobuo Yaegashi Koichi Hashimoto Chisato Mori Shuichi Ito Zentaro Yamagata Hidekuni Inadera Takeo Nakayama Tomotaka Sobue Masayuki Shima Hiroshige Nakamura Koichi Suganuma Koichi Kusuhara Takahiko Katoh Endotoxin concentration and persistent eczema in early childhood Although endotoxin concentration in the environment is negatively associated with atopic dermatitis (AD) onset in early childhood, the association between endotoxin concentration in the environment and eczema resolution in children with preexisting eczema is unclear. The aim of this study was to evaluate the association between endotoxin concentration in house dust and eczema persistence in young children. The authors used data from children participating in JECS (Japan Environment and Children's Study). In children who had AD or AD-like lesions at the age of 1 year, the authors investigated the association between the prevalence of eczema at the age of 3 years and endotoxin concentration (categorized by quartiles) in the dust on children's mattresses at the ages of 1.5 and 3 years. This study included 605 children. Eczema was significantly less prevalent among children whose mattresses were in the second and third quartiles of endotoxin concentration when they were 18 months old than among children whose mattresses were in the first quartile (adjusted odds ratio, 0.57 [95% confidence interval, 0.35-0.93] and adjusted odds ratio, 0.49 [95% confidence interval, 0.29-0.83], respectively). Moreover, of the children with eczema at age 3 years, those whose mattresses had endotoxin concentrations in the first quartile had significantly worse sleep disturbance caused by itchy rash (>1 time per week) than did those whose mattresses were in the third and fourth quartiles (20.0% vs 3.3% and 3.7%, both p values < 0.01). The findings indicate that low endotoxin exposure is associated with a higher prevalence of persistent eczema during early childhood. Wiley The Journal of Dermatology 1346-8138 50 5 646 655 20221228 10.1111/1346-8138.16686 36578125 irahara_makoto/published_papers/40741218 Saori Nagashima Mayu Yamamoto Yusuke Inuzuka Makoto Irahara Yumiko Miyaji Hiromi Tadaki Shuichi Ito Shizuka Masuda Yoshiyuki Ito Yuri Saito Saeko Kobayashi Hideaki Morita Takako Yoshioka Hirotaka Shimizu Katsuhiro Arai Yukihiro Ohya Hirohisa Saito Kenji Matsumoto Ichiro Nomura Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis. BACKGROUND: Non-esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are chronic inflammatory disorders with massive infiltration of eosinophils into the gastrointestinal tract. Food elimination diets are potentially effective treatments. But the existing dietary therapies have various weak points. We developed a new regimen to compensate for the shortcomings of the elemental diet and 6-food elimination diet. The new regimen consists of an amino-acid-based formula, potatoes, vegetables, fruits and restricted seasonings. We named it the "Rainbow Elimination Diet (ED)." The aims of this study were to evaluate the tolerability and safety of this diet. METHODS: A retrospective medical record examination was conducted at the National Center for Child Health and Development covering the period from January 2010 through December 2018. The medical records of patients (age 2-17 y) with histologically diagnosed non-EoE EGIDs were reviewed. The tolerability, nutritional intake, symptoms, and blood test findings were evaluated. RESULTS: Nineteen patients were offered several kinds of food-elimination diets. Seven patients (eosinophilic gastritis: 5; gastroenteritis: 1; duodenitis: 1) were treated with Rainbow ED. Six patients were compliant with this diet. The median duration of the diet induction phase was 15 days (range 14-30). All 5 patients who had had symptoms just before the induction phase became symptom-free. The body weight decreased in 5 patients (median -0.6 kg), probably because the serum protein increased, resulting in reduced edema. All 5 patients with hypoproteinemia had elevated serum albumin (median 2.9-3.5 g/dL). The ingested nutritional elements were calculated, and most of them were sufficient, except for fat and selenium. CONCLUSIONS: The Rainbow ED was well-tolerated and safe for pediatric non-EoE EGIDs. Allergology international : official journal of the Japanese Society of Allergology 72 2 306 315 20221119 10.1016/j.alit.2022.11.001 36414511 irahara_makoto/published_papers/40721725 Koji Nishimura Kiwako Yamamoto-Hanada Miori Sato Kenji Toyokuni Hiroya Ogita Tomoyuki Kiguchi Yoshitsune Miyagi Yusuke Inuzuka Mayako Saito-Abe Makoto Irahara Fumi Ishikawa Shigenori Kabashima Yumiko Miyaji Tatsuki Fukuie Ichiro Nomura Yukihiro Ohya Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan. The oral food challenge test (OFC) is the gold standard for evaluating the remission of food protein-induced enterocolitis syndrome (FPIES). Few acute FPIES remissions confirmed by OFC were reported. This study aimed to examine the OFC for Japanese children with acute FPIES to evaluate its remission. A retrospective cohort study was performed on children with acute FPIES with remission evaluation by OFC based on one food challenge dose (1/50, 1/10, 1/2, and full dose per day). Acute FPIES remission was observed in 65.2% of patients (15/23 patients). Vomiting episodes occurred with 1/50 full doses on the first day among 75% of positive patients. The median duration between the onset and OFC was 14 months (IQR, 8-24 months). Soy was the most common causative food, followed by egg yolk, milk, and wheat. All patients could receive OFC safely without intensive care unit care, based on the FPIES OFC protocol. The remission rate of acute FPIES was high. However, vomiting episodes commonly occurred with 1/50 full doses on the first day. This study suggested that our OFC protocol for acute FPIES was safe and feasible, but it might be safer for some patients to start at a minimal loading dose. Nutrients 14 19 null null 20221007 10.3390/nu14194158 36235810 irahara_makoto/published_papers/39974629 Ogita Hiroya 荻田 博也 Nomura Ichiro 野村 伊知郎 Miyagi Yoshitsune 宮城 俊雅 Kiguchi Tomoyuki 木口 智之 Inuzuka Yusuke 犬塚 祐介 Toyokuni Kenji 豊國 賢治 Irahara Makoto 苛原 誠 Ishikawa Fumi 石川 史 Sato Miori 佐藤 未織 Saito-Abe Mayako 齋藤 麻耶子 Miyaji Yumiko 宮地 裕美子 Kabashima Shigenori 樺島 重憲 Yamamoto-Hanada Kiwako 山本 貴和子 Fukuie Tatsuki 福家 辰樹 Takeuchi Ichiro 竹内 一朗 Arai Katsuhiro 新井 勝大 Ohya Yukihiro 大矢 幸弘 Two cases of pediatric eosinophilic esophagitis successfully treated by topical steroid therapy in addition to proton pump inhibitor プロトンポンプ阻害薬にステロイド局所療法を追加し奏功した小児好酸球性食道炎の2症例 We report two pediatric cases of eosinophilic esophagitis (EoE) that responded favorably to addition of topical steroid therapy to normal dose proton pump inhibitor (PPI) treatment according to the Japanese clinical practice guidelines for eosinophilic gastrointestinal disease in pediatric and adult patients. Case 1 was a 14-year-old boy who had a 1.5-year history of food impaction and heartburn. He was diagnosed with EoE with maximum eosinophilic infiltration of 50/HPF on esophageal biopsy. Administration of normal dose PPI as a first-line drug failed to achieve a sufficient response. However, addition of topical steroids successfully improved not only his symptoms but also his endoscopic and pathological findings. Case 2 was a 4-year-old boy who had a history of frequent vomiting since infancy. The vomiting worsened after solid food was introduced, and he sometimes refused food. He was diagnosed with EoE with maximum eosinophilic infiltration of 83/HPF on esophageal biopsy. The vomiting disappeared by 10 weeks after starting normal dose PPI treatment, but he required concomitant treatment with topical steroids from 26 weeks of treatment because his food refusal recurred. His vomiting and food refusal improved with these treatments but recurred when the topical steroids were interrupted. After resuming the treatment, his symptoms, endoscopic findings, and pathological findings improved. 本邦の幼児・成人好酸球性消化管疾患診療ガイドラインの治療アルゴリズムと同様の流れで，通常量のプロトンポンプ阻害薬(PPI)治療では十分な効果が得られずステロイド局所療法を追加したところ良好な治療経過が得られた小児好酸球性食道炎(EoE)の2症例を経験したので報告する． 症例1は14歳男子．18か月前から食物のつかえ感と胸焼けがあった．食道粘膜上皮内に最大50/HPFの好酸球浸潤を認めEoEと診断した．通常量のPPI治療では効果不十分であり，ステロイド局所療法の開始により症状と組織学的所見の改善を認めた．症例2は4歳男児．乳幼児期から嘔吐が多く固形物摂取開始後に増加し，摂食拒否も出現した．食道粘膜上皮内に最大83/HPFの好酸球浸潤を認めEoEと診断した．通常量のPPI治療開始後一度は症状の消失と組織学的所見の改善傾向を認めたが，摂食拒否が再出現したため，ステロイド局所療法を開始した．その後摂食拒否は消失したが，中断すると嘔吐症状の再燃を認めた．ステロイド局所療法再開後，症状と組織学的所見の改善を認めた． THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY 一般社団法人日本小児アレルギー学会 Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 日本小児アレルギー学会誌 1882-2738 36 3 224 233 20220820 10.3388/jspaci.36.224 1390574655179236352 irahara_makoto/published_papers/39892736 Makoto Irahara Kiwako Yamamoto-Hanada Mayako Saito-Abe Miori Sato Yumiko Miyaji Limin Yang Hiroshi Mitsubuchi Masako Oda Masafumi Sanefuji Shouichi Ohga Akihiko Ikegami Nathan Mise Reiko Suga Masayuki Shimono Shin Yamazaki Shoji F Nakayama Yukihiro Ohya Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort. BACKGROUND: Allergen-specific immunoglobulins have a crucial role in allergic diseases. Most wheeze episodes develop before school age, and allergic rhinitis later develops during early elementary school years. However, the clinical background and cytokine/chemokine profiles associated with changes in immunoglobulins during early school-age are poorly understood. METHODS: This study used blood samples from children participating in the JECS Pilot Study. We examined nineteen kinds of aeroallergen-specific immunoglobulins (IgE, IgG1, IgG4, and IgA) levels in patients at age 6 and age 8. Fluctuations of Der f 1- and Cry j 1-specific immunoglobulins levels during the two periods were compared to assess the frequency of allergic statuses and clusters of cytokine/chemokine profiles. RESULTS: The medians of aeroallergen-specific IgE levels did not fluctuate, and almost all IgG1 and IgG4 decreased. In IgA, four (e.g., Der f 1) increased, whereas the other four (e.g., Cry j 1) decreased. The ratio of the Der f 1-specific IgG1 level at age 8 to that at age 6 was higher in children with poor asthma control than in children with better asthma control. Moreover, the cytokine/chemokine cluster with relatively lower IL-33 and higher CXCL7/NAP2 was associated with lower Der f 1- and Cry j 1-specific IgG4 levels, but not IgE levels. CONCLUSIONS: The cluster of cytokine/chemokine profiles characterized by lower IL-33 and higher CXCL7/NAP2 was associated with the maintenance of aeroallergen-specific IgG4 levels. This result provides a basis for considering the control of aeroallergen-specific immunoglobulins. Allergology international : official journal of the Japanese Society of Allergology 71 3 335 344 20220700 10.1016/j.alit.2022.01.002 35219607 irahara_makoto/published_papers/39892738 Hiroki Murai Makoto Irahara Mayumi Sugimoto Yuri Takaoka Kyohei Takahashi Takuya Wada Kiwako Yamamoto-Hanada Ikuo Okafuji Yoshiyuki Yamada Masaki Futamura Motohiro Ebisawa Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review. BACKGROUND: IgE-mediated egg allergy is a common food allergy worldwide. Patients with egg allergy are known to easily achieve tolerance compared to other allergens such as nuts. Oral food challenge (OFC) is often performed on patients diagnosed with or suspected of having IgE-mediated food allergy, but whether hen's egg OFC is useful in IgE-dependent egg allergy patients to avoid complete elimination remains unknown. METHODS: We identified articles in which OFCs were performed in Japanese patients diagnosed with or suspected of having IgE-mediated egg allergy. We evaluated whether the OFCs were useful to avoid the complete elimination of eggs by assessing the following: (1) the number of patients who could avoid complete elimination; (2) the number of patients who experienced serious adverse events (SAEs); or (3) adverse events (AEs); (4) improvement in quality of life (QOL); and (5) immunological changes. RESULTS: Fifty-nine articles were selected in the study; all the references were case series or case studies in which OFC was compared to pre-challenge conditions. The overall negative ratio against egg OFC was 62.7%, but an additional 71.9% of OFC-positive patients could take eggs when expanded to partial elimination. Of the 4182 cases, 1146 showed AEs in the OFC, and two cases reached an SAE. Two reports showed an improvement in QOL and immunological changes, although the evidence was weak. CONCLUSIONS: OFCs against eggs may be useful to avoid complete elimination, but medical professionals should proceed with the test safely and carefully. Allergology international : official journal of the Japanese Society of Allergology 71 2 221 229 20220400 10.1016/j.alit.2021.09.005 34663557 irahara_makoto/published_papers/39892737 Limin Yang Miori Sato Mayako Saito-Abe Makoto Irahara Minaho Nishizato Hatoko Sasaki Mizuho Konishi Kazue Ishitsuka Hidetoshi Mezawa Kiwako Yamamoto-Hanada Yukihiro Ohya 25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children's study (JECS). BACKGROUND: The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed the prevalence of vitamin D deficiency and insufficiency in 2-year-old Japanese children using data from a large ongoing birth cohort study. METHODS: Data for analysis was obtained from the Japan Environment and Children's Study (JECS) and a Sub-Cohort Study (SCS) of JECS. We evaluated the children's serum 25(OH) D levels by 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and the rates of vitamin D deficiency or insufficiency. We also presented a weighted prevalence rate for vitamin D deficiency or insufficiency among all children in JECS. RESULTS: After excluding children with missing 25(OH)D2 or 25(OH)D3 data, we analyzed 4655 remaining children, of whom 24.7% (95% CI, 23.5-26.0%) had vitamin D deficiency (< 20 ng/mL), and 51.3% (95% CI, 49.8-52.7%) were at risk of vitamin D insufficiency (20-30 ng/mL). The estimated prevalence of vitamin D deficiency and insufficiency among all children in JECS were 25.4% (95% CI, 24.1-26.7%) and 50.9% (95% CI, 49.4-52.4%). Vitamin D deficiency was found in 22.9% of boys and 26.5% of girls. Median serum 25(OH) D concentrations were lower among participants measured during winter and spring than among those measured in summer and autumn. The highest rate of vitamin D deficiency was observed in Hokkaido, the northernmost prefecture of Japan. CONCLUSION: We analyzed data on serum 25(OH) D levels from a birth cohort study and found that vitamin D deficiency and insufficiency are very common among 2-year-old Japanese children. Sex, season, and latitude affect serum 25(OH) D concentrations. BMC pediatrics 21 1 539 539 20211202 10.1186/s12887-021-03005-3 34856947 irahara_makoto/published_papers/41468196 村井 宏生 苛原 誠 杉本 真弓 高岡 有理 高橋 亨平 和田 拓也 山本 貴和子 岡藤 郁夫 二村 昌樹 山田 佳之 海老澤 元宏 【二次出版】CQ3 日本のIgE依存性鶏卵アレルギー患者もしくはその疑いのある者において，食物経口負荷試験は完全除去回避に有用か? (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 35 5 490 502 20211200 irahara_makoto/published_papers/39892739 Limin Yang Miori Sato Mayako Saito-Abe Makoto Irahara Minaho Nishizato Hatoko Sasaki Mizuho Konishi Kazue Ishitsuka Hidetoshi Mezawa Kiwako Yamamoto-Hanada Kenji Matsumoto Yukihiro Ohya Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). BACKGROUND: Hypertensive disorders of pregnancy (HDP) are one of the most common medical conditions that women encounter during pregnancy. Whether or not hypertensive disorders of pregnancy (HDP) are associated with allergic conditions in the offspring is unclear. This study used data from a large Japanese birth cohort to investigate whether HDP contributes to the development of allergic conditions in the offspring at 3 years. We also assessed the effect of blood pressure at different pregnancy trimesters on children's allergies. METHODS: We obtained data from the Japan Environment and Children's Study (JECS), which included 104 062 fetal records. After data selection, we analyzed 77 505 mother-child pairs, using logistic regression models to examine the relationships between HDP or the mother's blood pressure and their children's allergic conditions. In addition, we also evaluated the effect of HDP during pregnancy on allergies with a propensity score matched dataset, using a logistic regression model that predicts the conditional probability of whether a mother belonged to the HDP or non-HDP group. RESULTS: Among the 77 505 mothers eligible for analysis, 2334 (3.0%) had HDP. Percentages of women with hypertension were 1.7% in early gestation, 1.0% in mid-gestation, and 1.6% in late gestation. After adjusting for multiple potential confounders, HDP contributed nothing to allergy development in offspring. Children born to women with hypertension were no more likely than those without to have allergic conditions at 3 years of age. The propensity score matched dataset showed similar findings. CONCLUSION: HDP and high blood pressure during pregnancy are apparently not risk factors for developing allergy in offspring. This information may help clinicians in counseling women who suffered HDP during pregnancy. The World Allergy Organization journal 14 9 100581 100581 20210900 10.1016/j.waojou.2021.100581 34567349 irahara_makoto/published_papers/39892742 Limin Yang Miori Sato Mayako Saito-Abe Makoto Irahara Minaho Nishizato Hatoko Sasaki Mizuho Konishi Kazue Ishitsuka Hidetoshi Mezawa Kiwako Yamamoto-Hanada Kenji Matsumoto Yukihiro Ohya On Behalf Of The Japan Environment And Children's Study Jecs Group Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children's Study (JECS). Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0-3 years from the Japan Environment and Children's Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother-child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7-14.2%) and 12.5% (12.3-12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed. Nutrients 13 3 null null 20210301 10.3390/nu13030810 33804474 irahara_makoto/published_papers/39892743 Mayko Saito-Abe Kiwako Yamamoto-Hanada Kyongsun Pak Miori Sato Makoto Irahara Hidetoshi Mezawa Hatoko Sasaki Minaho Nishizato Kazue Ishitsuka Mizuho Konishi Limin Yang Yukihiro Ohya Kohta Suzuki Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study. INTRODUCTION: Previous studies have reported that maternal asthma increases the risk of preterm birth. We hypothesized that inflammatory reactions caused by allergic diseases might affect the uterine environment and, subsequently, perinatal outcomes. The objective of this study was to examine the associations between allergic features among mothers and preterm pregnancy outcomes in a nationwide birth cohort. METHODS: We analyzed data from pregnant women obtained from the Japanese Environment and Children's Study (JECS), a nationwide general birth cohort study. We used binomial and multinomial logistic regression models to examine the associations between maternal allergic features and preterm birth, threatened preterm labor (TPL), and preterm premature rupture of the membrane (PPROM). RESULTS: A total of 97,683 pregnant women were included. Prevalence of preterm birth, TPL, and PPROM was 4.7, 19.6, and 1.2%, respectively. Maternal history of allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, food allergy, drug allergy, and contact dermatitis) increased the risk of TPL(adjusted odds ratio [aOR] = 1.11 [95% CI: 1.06-1.17], aOR = 1.12 [1.08-1.16], aOR = 1.10 [1.04-1.16], aOR = 1.17 [1.09-1.26], aOR = 1.35 [1.23-1.48], and aOR = 1.34 [1.20-1.49], respectively). Although some maternal allergic features showed a negative association with preterm birth, the variables affecting preterm birth differed according to the gestational age of the fetus (22-33 weeks vs. 34-36 weeks). There were no significant associations between maternal allergic features and PPROM. CONCLUSION: Maternal allergic disease, except atopic dermatitis, may increase the risk of TPL. Comorbidity of maternal allergic disorders and perinatal adverse outcomes require further investigation. International archives of allergy and immunology 182 7 650 662 20210000 10.1159/000513749 33601376 irahara_makoto/published_papers/39892741 Tomoyuki Kiguchi Kiwako Yamamoto-Hanada Mayako Saito-Abe Miori Sato Makoto Irahara Hiroya Ogita Yoshitsune Miyagi Yusuke Inuzuka Kenji Toyokuni Koji Nishimura Fumi Ishikawa Yumiko Miyaji Shigenori Kabashima Tatsuki Fukuie Masami Narita Yukihiro Ohya Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study. Allergic rhino-conjunctivitis with pollen allergy has been prevalent worldwide and Pollen-food allergy syndrome (PFAS) refers to individuals with pollen allergy who develop oral allergy syndrome (OAS) on consuming fruits and vegetables. The prevalence of PFAS varies by region and that in Japanese adolescents remains to be elucidated. In this cross-sectional study, we examined the epidemiological characteristics of PFAS in a general population of Japanese adolescents according to pollen allergy, OAS, and IgE component sensitization. Participants comprised adolescents, at age 13 years, from a prospective birth cohort study in Japan. We administered questionnaires to collect information from parents regarding pollen allergy, PFAS and OAS at each child's age 13 years. ImmunoCAP ISAC was used to assess IgE component sensitization. Among 506 participants with a complete questionnaire and ISAC measurement results, 56.5% had a history of hay fever, 16.0% had a history of OAS, 51.0% had pollen allergy, and 11.7% had a history of PFAS; additionally, 72.7% were sensitized to one or more tree, grass, and/or weed allergens. The most common sensitization (95.7%) among adolescents with pollen allergy was to Japanese cedar (Cry j 1). The most common causal foods were kiwi and pineapple (both 39.0%). Knowledge levels about PFAS were poor among affected adolescents. We found a high prevalence of PFAS among adolescents in Japan. Although it affects approximately 1/10 adolescents in the general population, public awareness regarding PFAS is poor. Interventional strategies are needed to increase knowledge and to prevent PFAS in the general population. PloS one 16 4 e0249649 null 20210000 10.1371/journal.pone.0249649 33852622 irahara_makoto/published_papers/39892740 Mayako Saito-Abe Kiwako Yamamoto-Hanada Kensuke Shoji Miori Sato Makoto Irahara Yu Taniguchi Makiko Sekiyama Nathan Mise Akihiko Ikegami Masayuki Shimono Reiko Suga Masafumi Sanefuji Shouichi Ohga Masako Oda Hiroshi Mitsubuchi Isao Miyairi Yukihiro Ohya Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children's Pilot Study. BACKGROUND: The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. METHODS: The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. RESULTS: This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. CONCLUSIONS: Children with allergies mount and maintain a comparable immune response to the measles vaccine. PloS one 16 9 e0257721 null 20210000 10.1371/journal.pone.0257721 34551012 irahara_makoto/published_papers/39892774 渋谷 紀子 斉藤 恵美子 苛原 誠 木戸 博 高感度測定法による新生児血中特異的IgEと乳児期の食物アレルギー発症に関する検討 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 5 530 536 20201200 irahara_makoto/published_papers/39892745 Kiwako Yamamoto-Hanada Kyongsun Pak Mayako Saito-Abe Limin Yang Miori Sato Makoto Irahara Hidetoshi Mezawa Hatoko Sasaki Minaho Nishizato Kazue Ishitsuka Yukihiro Ohya Allergy and immunology in young children of Japan: The JECS cohort. BACKGROUND: Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented. OBJECTIVE: To characterize epidemiological signatures of allergic and immunological disease in young children in Japan. METHODS: This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data. RESULTS: The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years. CONCLUSION: These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency. The World Allergy Organization journal 13 11 100479 100479 20201100 10.1016/j.waojou.2020.100479 33204389 irahara_makoto/published_papers/39892762 Miori Sato Kiwako Yamamoto-Hanada Hitomi Tada Makoto Irahara Mayako Saito-Abe Kenji Matsumoto Kyongsun Pak Hiroshi Kido Yukihiro Ohya Diagnostic performance of IgE avidity for hen's egg allergy in young infants Elsevier BV The Journal of Allergy and Clinical Immunology: In Practice 2213-2198 8 7 2417 2420.e6 20200700 10.1016/j.jaip.2020.03.025 irahara_makoto/published_papers/39892746 Makoto Irahara Ichiro Nomura Ichiro Takeuchi Kiwako Yamamoto-Hanada Hirotaka Shimizu Tatsuki Fukuie Takako Yoshioka Katsuhiro Arai Yukihiro Ohya Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome. The incidence of eosinophilic esophagitis (EoE) and pollen-food allergy syndrome (PFAS) is increasing worldwide, and coexistence of these 2 diseases has been reported in adults. In children, however, these conditions have not been reported as comorbidities probably because sensitization to aeroallergens occurs at an older age. We report the case of a boy with EoE and PFAS. He had had intermittent vomiting since 2 years of age. At 7 years of age, he experienced an episode of itchiness of the lips and throat for the first time, followed by vomiting, immediately after ingesting some raw fruits. We diagnosed PFAS based on the skin prick test at 8 years of age and diagnosed EoE by esophagogastroduodenoscopy 11 months after the diagnose of PFAS. His digestive symptoms did not disappear despite eliminating the fruits responsible for PFAS, but esomeprazole improved his symptoms. The incidence of EoE and PFAS as comorbidities in children might increase in the future. Asia Pacific allergy 10 3 e28 null 20200700 10.5415/apallergy.2020.10.e28 32789113 irahara_makoto/published_papers/39892834 西村 幸士 福家 辰樹 宮地 裕美子 犬塚 祐介 豊国 賢治 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 山本 貴和子 成田 雅美 野村 伊知郎 大矢 幸弘 経口免疫療法中に異食症により発見された好酸球性胃腸炎の1例 (一社)日本アレルギー学会 アレルギー 1347-7935 69 2 123 128 20200300 irahara_makoto/published_papers/39996830 苛原 誠 野村 伊知郎 荻田 博也 木口 智之 宮城 俊雅 犬塚 祐介 豊國 賢治 西村 幸士 石川 史 竹内 一朗 佐藤 美織 齋藤 麻耶子 樺島 重憲 宮地 裕美子 山本 貴和子 福家 辰樹 新井 勝大 大矢 幸弘 Pollen-food allergy syndromeと好酸球性食道炎を合併した男児例 (公社)日本小児科学会 日本小児科学会雑誌 0001-6543 124 2 468 468 20200200 irahara_makoto/published_papers/39892748 Miori Sato Kiwako Yamamoto-Hanada Limin Yang Makoto Irahara Fumi Ishikawa Motoko Iwama-Mitsui Mayako Saito-Abe Yumiko Miyaji Shinichiro Inagaki Tatsuki Fukuie Ichiro Nomura Masami Narita Kohta Suzuki Yukihiro Ohya Complementary and alternative medicine and atopic dermatitis in children. Journal of dermatological science 97 1 80 82 20200100 10.1016/j.jdermsci.2019.11.011 31837939 irahara_makoto/published_papers/39892747 Makoto Irahara Kiwako Yamamoto-Hanada Limin Yang Mayako Saito-Abe Miori Sato Yusuke Inuzuka Kenji Toyokuni Koji Nishimura Fumi Ishikawa Yumiko Miyaji Tatsuki Fukuie Masami Narita Yukihiro Ohya Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo. BACKGROUND: In Japan, swimming school attendance is promoted as a form of therapy or as a prophylactic measure against asthma in young children. However, the putative beneficial effects have not been sufficiently verified. OBJECTIVE: The aim of the present study was to clarify whether or not swimming school attendance at age 3 years affects the onset and/or improvement of wheeze and rhinitis at age 5 years. METHODS: This study was a single-center, prospective, general, longitudinal cohort study (T-CHILD Study). Between November 2003 and December 2005, 1776 pregnant women were enrolled, and their offspring were followed up until age 5 years. Swimming school attendance at age 3 years and the presence of wheeze and/or rhinitis in the previous one year were examined using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. The relationship between swimming school attendance and wheeze and/or rhinitis was analyzed using multivariable logistic regression analysis. RESULTS: Data on the 1097 children were analyzed. At age 3 years, 126 (11.5%) children attended a swimming school, and at age 5 years, the prevalence of wheeze was 180 (16.4%) while that of rhinitis was 387 (35.3%). Swimming school attendance at age 3 showed no significant relationship with the development of either wheeze (aOR 0.83, 95% CI (0.43-1.60) or rhinitis (aOR 0.80, 95% CI (0.43-1.60) at age 5. CONCLUSIONS: Swimming school attendance at age 3 years showed neither a preventive nor therapeutic effect on wheeze or rhinitis at age 5 years. There is thus no scientific evidence yet that swimming school attendance has a positive impact on the development of childhood wheeze or rhinitis. PloS one 15 6 e0234161 null 20200000 10.1371/journal.pone.0234161 32516323 irahara_makoto/published_papers/39892744 Yoshitsune Miyagi Kiwako Yamamoto-Hanada Hiroya Ogita Tomoyuki Kiguchi Yusuke Inuzuka Kenji Toyokuni Koji Nishimura Makoto Irahara Fumi Ishikawa Miori Sato Mayako Saito-Abe Yumiko Miyaji Shigenori Kabashima Tatsuki Fukuie Ichiro Nomura Yukihiro Ohya Avoidance of Hen's Egg Based on IgE Levels Should Be Avoided for Children With Hen's Egg Allergy. Background: Although hen's egg (HE) allergy was thought to be usually resolved by late childhood, majority of HE allergy patients with a high level of egg white (HEW)-specific IgE could not acquire tolerance for HE by age 8 years. Objective: The aim is to investigate whether the avoidance of HE until 6 years of age increased the risk of heated HE allergy at age 6 years. Methods: This was a retrospective case-control study. The HE tolerance children (n = 17) and children with low-dose HE reactor [a positive reaction to ≤ 4 g of heated HEW in oral food challenges (OFCs)] children (n = 26) were included based on the results of OFC at 6 years old. Multivariate logistic regression analysis was applied to examine the associations between HE avoidance until age 6 years and HE allergy status confirmed by OFC, adjusting the level of ovomucoid-specific IgE (OM-sIgE) during early infancy. Results: A lower proportion of strict avoidance of HE was observed in the HE tolerance group than in the low-dose HE reactor group (6 vs. 46%, p = 0.006). OM-sIgE levels in children younger than 2 years old were significantly higher in the low-dose HE reactor group than those in the HE tolerance group (median [interquartile], 26.7 UA/mL [11.9-53.4] vs. 7.9 UA/mL [0.35-23.4]; p =0.024). The avoidance of HE until 6 years of age increased the risk of heated HE allergy even after adjusting OM-sIgE levels. Conclusions: The long-term avoidance of HE from infancy increased the risk of heated HE allergy confirmed by OFC at age 6 years. Frontiers in pediatrics 8 583224 583224 20200000 10.3389/fped.2020.583224 33520887 irahara_makoto/published_papers/39892749 Makoto Irahara Wakako Shinahara Mayumi Sugimoto Yukiko Ogawa Keiji Shitsukawa Kenji Kubota Yukihiro Ohya Hirohisa Saito Shoji Kagami Hiroshi Kido Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 30 8 857 860 20191200 10.1111/pai.13116 31441111 irahara_makoto/published_papers/39892751 Kiwako Yamamoto-Hanada Limin Yang Mayako Saito-Abe Miori Sato Yusuke Inuzuka Kenji Toyokuni Koji Nishimura Makoto Irahara Fumi Ishikawa Yumiko Miyaji Tatsuki Fukuie Masami Narita Hirohisa Saito Yukihiro Ohya Four phenotypes of atopic dermatitis in Japanese children: A general population birth cohort study. Allergology international : official journal of the Japanese Society of Allergology 68 4 521 523 20191000 10.1016/j.alit.2019.02.010 30935805 irahara_makoto/published_papers/39892752 Makoto Irahara Wakako Shinahara Mayumi Sugimoto Yukiko Ogawa Keiji Shitsukawa Kenji Kubota Limin Yang Yukihiro Ohya Hirohisa Saito Shoji Kagami Kokichi Arisawa Hiroshi Kido Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy. INTRODUCTION: Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. METHODS: Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. RESULTS: Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). CONCLUSIONS: Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE. Immunity, inflammation and disease 7 2 74 85 20190600 10.1002/iid3.245 30859748 irahara_makoto/published_papers/39892750 Ayumi Sasaki Mayumi Sugimoto Narumi Tokaji Makoto Irahara Koichi Okamoto Hisanori Uehara Shoji Kagami Efficacy of an elimination diet in a patient with eosinophilic gastroenteritis : a pediatric case with multiple food allergies. Eosinophilic gastrointestinal disorders are chronic inflammatory diseases in which eosinophils highly infiltrate into gastrointestinal tissue, resulting in gastrointestinal dysfunction. Here, we report a case of pediatric eosinophilic gastroenteritis (EGE). A 7-year-old boy with multiple food allergies (cow milk, hen's egg, fish,shellfish, and chicken) was admitted to our hospital because of continuous abdominal pain and vomiting. His soy allergy had been diagnosed to have oral tolerance based on an oral food challenge at the age of 6 years. He was diagnosed with EGE based on biopsy findings showing eosinophilic infiltration ( 20 eosinophils per high-power field) into the gastrointestinal mucosa. A diet eliminating soy, wheat, beef, pork, rice, and sesame in addition to the food that had already been eliminated and oral corticosteroids improved his symptoms and peripheral eosinophilia. A relapse of both abdominal pain and peripheral eosinophilia after the reintroduction of soy or pork identified them as foods causative of EGE. This report highlights the utility of elimination diets in improving EGE symptoms and the subsequent reintroduction of offending foods in identifying causative foods. Furthermore,EGE onset should be considered when introducing potentially allergic food in the management of food allergy. J. Med. Invest. 66 : 201-204, February, 2019. The journal of medical investigation : JMI 66 1.2 201 204 20190000 10.2152/jmi.66.201 31064942 irahara_makoto/published_papers/39892753 Masaya Takahashi Kazuhiko Soejima Shoichiro Taniuchi Yasuko Hatano Sohsaku Yamanouchi Hideki Ishikawa Makoto Irahara Youhei Sasaki Hiroshi Kido Kazunari Kaneko Author Correction: Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial. A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Scientific reports 8 1 12812 12812 20180821 10.1038/s41598-018-30919-3 30127456 irahara_makoto/published_papers/39892854 武井 美貴子 古本 哲朗 苛原 誠 阿部 孝典 坂本 恵子 山内 英雄 西山 謹吾 吉本 啓一郎 自殺目的にジフェンヒドラミンを過量服用し，注意欠如多動性障害と診断された思春期女児例 (一社)高知県医師会 高知県医師会医学雑誌 2186-9863 23 1 262 267 20180300 irahara_makoto/published_papers/39892791 Masaya Takahashi Kazuhiko Soejima Shoichiro Taniuchi Yasuko Hatano Sohsaku Yamanouchi Hideki Ishikawa Makoto Irahara Youhei Sasaki Hiroshi Kido Kazunari Kaneko Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial. We evaluated the efficacy and safety of oral immunotherapy (OIT) combined with 24 weeks of omalizumab (OMB) at inducing desensitization in children with cow's milk allergy (CM) compared with an untreated group. The present study was a prospective randomized controlled trial. Sixteen patients (age, 6-14 years) with high IgE levels to CM were enrolled in the present study. Patients were randomized 1:1 to receive OMB-OIT group or untreated group. The primary outcome was the induction of desensitization at 8 weeks after OMB was discontinued in OMB-OIT treated group and at 32 weeks after study entry. None of the 6 children in the untreated group developed desensitization to CM while all of the 10 children in the OIT-OMB treated group achieved desensitization (P < 0.001). A significantly decreased wheal diameter in response to a skin prick test using CM was found in the OMB-OIT treated group (P < 0.05). These data suggest that OIT combined with OMB using microwave heated CM may help to induce desensitization for children with high-risk CM allergy. This prospective randomized controlled trial was intended for 50 participants but was prematurely discontinued due to overwhelming superiority of OMB combined with microwave heated OIT over CM avoidance. Scientific reports 7 1 17453 17453 20171212 10.1038/s41598-017-16730-6 29234055 irahara_makoto/published_papers/39892863 苛原 誠 小川 由紀子 市岡 隆男 香美 祥二 難治性気管支喘息に対するオマリズマブ投与で難治性米アレルギーが改善した男児例 (株)総合医学社 小児科臨床 0021-518X 70 3 349 355 20170300 irahara_makoto/published_papers/39892792 Mayumi Sugimoto Norio Kamemura Mizuho Nagao Makoto Irahara Shoji Kagami Takao Fujisawa Hiroshi Kido Differential response in allergen-specific IgE, IgGs, and IgA levels for predicting outcome of oral immunotherapy. BACKGROUND: Oral immunotherapy (OIT) induces desensitization and/or tolerance in patients with persistent food allergy, but the biomarkers of clinical outcomes remain obscure. Although OIT-induced changes in serum allergen-specific IgE and IgG4 levels have been investigated, the response of other allergen-specific IgG subclasses and IgA during OIT remains obscure. METHODS: A pilot study was conducted to investigate egg OIT-induced changes in allergen-specific IgE, IgG subclasses, and IgA levels and search for possible prediction biomarkers of desensitization. We measured serum levels of egg white-, ovomucoid-, and ovalbumin-specific IgE, IgA, and IgG subclasses by high-sensitivity allergen microarray in 26 children with egg allergy who received rush OIT. RESULTS: Allergen-specific IgE gradually decreased while IgG4 increased during 12-month OIT. Serum levels of IgG1, IgG3, and IgA increased significantly after the rush phase, then decreased during the maintenance phase. IgG2 levels changed in a manner similar to that of IgG4. In particular, significantly high fold increases in egg white-specific IgG1, relative to baseline, after the rush phase and high IgA levels before OIT were observed in responders, compared with low-responders to OIT. Patients who could not keep desensitization showed relatively small changes in all immunoglobulin levels during OIT. CONCLUSION: The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after rush phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 27 3 276 82 20160500 10.1111/pai.12535 26764899 irahara_makoto/misc/52783320 苛原誠 苛原誠 福家辰樹 川崎洋 川崎洋 諫山純 増田奏衣 青戸良賢 森田英明 松本健治 吉田和恵 吉田和恵 山本貴和子 大矢幸弘 大矢幸弘 新生児期マイクロバイオームと生後6カ月の卵白感作との関連 日本小児アレルギー学会誌(Web) 1882-2738 39 4 null null 20250000 irahara_makoto/misc/43602133 山本貴和子 山本貴和子 苛原誠 小児のアレルギー 小児アレルギー疾患の疫学 日本医師会雑誌 0021-4493 152 5 null null 20230000 irahara_makoto/misc/39892768 村井 宏生 苛原 誠 杉本 真弓 高岡 有理 高橋 亨平 和田 拓也 山本 貴和子 岡藤 郁夫 二村 昌樹 山田 佳之 海老澤 元宏 CQ3 日本のIgE依存性鶏卵アレルギー患者もしくはその疑いのある者において，食物経口負荷試験は完全除去回避に有用か? (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 35 5 490 502 20211200 irahara_makoto/misc/39996832 宮地 裕美子 山本 貴和子 苛原 誠 石川 史 岩間 元子 佐藤 未織 齋藤 麻耶子 稲垣 真一郎 福家 辰樹 成田 雅美 野村 伊知郎 大矢 幸弘 学童期以上の重症アトピー性皮膚炎入院症例の悪化の背景因子と長期予後についての検討 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 35 4 393 393 20210900 irahara_makoto/misc/39996834 山本 貴和子 齋藤 麻耶子 佐藤 未織 苛原 誠 大矢 幸弘 アレルギー疾患の疫学・発症因子・発症予防 全国一般乳幼児のアレルギー症状・疾患の推移 エコチル調査より (一社)日本アレルギー学会 アレルギー 1347-7935 70 6-7 784 784 20210800 irahara_makoto/misc/39996833 佐藤 未織 山本 貴和子 齋藤 麻耶子 苛原 誠 野村 伊知郎 大矢 幸弘 アレルギー疾患の疫学・発症因子・発症予防 本邦の新生児・乳児消化管アレルギーの有病率及び原因食物について エコチル調査より (一社)日本アレルギー学会 アレルギー 1347-7935 70 6-7 784 784 20210800 irahara_makoto/misc/39996831 齋藤 麻耶子 山本 貴和子 佐藤 未織 苛原 誠 大矢 幸弘 鈴木 孝太 アレルギー疾患の疫学・発症因子・発症予防 エコチル調査における母親のアレルギーと早産との関連について (一社)日本アレルギー学会 アレルギー 1347-7935 70 6-7 784 784 20210800 irahara_makoto/misc/39996827 佐藤 未織 山本 貴和子 苛原 誠 豊國 賢治 上滝 恵理華 水澤 直美 森田 英明 松本 健治 大矢 幸弘 牛乳アレルギー治療(経口免疫療法)に対する有効性検証試験(乳酸菌発酵果汁飲料を用いた二重盲検プラセボ対照並行群間比較試験-パイロット研究) (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 488 488 20200900 irahara_makoto/misc/39996826 齋藤 麻耶子 佐藤 未織 山本 貴和子 多田 仁美 苛原 誠 松本 健治 朴 慶純 木戸 博 大矢 幸弘 加熱鶏卵アレルギー児におけるIgE抗体親和性の診断能についての検討 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 505 505 20200900 irahara_makoto/misc/39996825 木口 智之 福家 辰樹 荻田 博也 犬塚 祐介 豊國 賢治 石川 史 苛原 誠 佐藤 未織 齋藤 麻耶子 宮地 裕美子 樺島 重憲 山本 貴和子 野村 伊知郎 大矢 幸弘 食物経口負荷試験における食物別の口腔周囲症状出現に関する検討 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 506 506 20200900 irahara_makoto/misc/39996824 荻田 博也 福家 辰樹 木口 智之 犬塚 祐介 豊國 賢治 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 樺島 重憲 山本 貴和子 野村 伊知郎 大矢 幸弘 斎藤 博久 鶏卵アレルギーを疑う乳児に対する安全な卵白導入量の検討 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 509 509 20200900 irahara_makoto/misc/39996823 苛原 誠 福家 辰樹 荻田 博也 木口 智之 犬塚 祐介 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 樺島 重憲 山本 貴和子 大矢 幸弘 就学前のダニ特異的IgE抗体価の上昇は思春期における末梢気道抵抗の上昇と関連する (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 513 513 20200900 irahara_makoto/misc/39996822 豊國 賢治 山本 貴和子 荻田 博也 木口 智之 犬塚 祐介 石川 史 苛原 誠 佐藤 未織 齋藤 麻耶子 宮地 裕美子 樺島 重憲 福家 辰樹 野村 伊知郎 大矢 幸弘 妊娠中及び乳幼児期のイヌ・ネコ飼育とその後のアレルギー疾患との関連 成育コホートより (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 34 4 520 520 20200900 irahara_makoto/misc/39892836 苛原 誠 成田 雅美 【周産期相談310 お母さんへの回答マニュアル 第3版】新生児・乳児編 栄養，排泄など 新生児期 アレルギーが心配です．アレルギーにならないミルクはありますか? (株)東京医学社 周産期医学 0386-9881 49 593 595 20191200 irahara_makoto/misc/39892835 苛原 誠 成田 雅美 【周産期相談310 お母さんへの回答マニュアル 第3版】新生児・乳児編 栄養，排泄など 新生児期 私(母親)がアトピー性皮膚炎なのですが，授乳をするにあたって私が避けるべき食品はありますか? (株)東京医学社 周産期医学 0386-9881 49 596 598 20191200 irahara_makoto/misc/41580037 木口 智之 宮地 裕美子 犬塚 祐介 豊國 賢治 西村 幸士 石川 史 苛原 誠 佐藤 未織 齋藤 麻耶子 山本 貴和子 福家 辰樹 野村 伊知郎 大矢 幸弘 当院のゴマ食物負荷試験におけるゴマの形状に基づく検討 日本小児アレルギー学会 日本小児アレルギー学会誌 0914-2649 33 4 557 557 20191000 irahara_makoto/misc/39996844 苛原 誠 山本 貴和子 犬塚 祐介 豊國 賢治 西村 幸士 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 福家 辰樹 成田 雅美 大矢 幸弘 水泳教室への参加がその後の喘鳴と鼻炎発症を予防することができるのか 成育コホート研究より (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 573 573 20191000 irahara_makoto/misc/39996843 豊國 賢治 福家 辰樹 山本 貴和子 犬塚 祐介 西村 幸士 石川 史 苛原 誠 佐藤 未織 齋藤 麻耶子 宮地 裕美子 成田 雅美 斎藤 博久 大矢 幸弘 幼児期の受動喫煙とその後の吸入抗原感作・アレルギー疾患との関連 成育コホートより (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 604 604 20191000 irahara_makoto/misc/39996839 犬塚 祐介 宮地 裕美子 岩間 元子 豊國 賢治 西村 幸士 苛原 誠 石川 史 佐藤 未織 宮田 真貴子 齋藤 麻耶子 山本 貴和子 福家 辰樹 須田 友子 成田 雅美 野村 伊知郎 大矢 幸弘 N of 1 RCTと尿中PGDMにより適切な評価を行った食物アレルギーの9歳男児例 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 547 547 20191000 irahara_makoto/misc/39996838 荻田 博也 宮地 裕美子 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 樺島 重憲 山本 貴和子 福家 辰樹 野村 伊知郎 佐藤 琢郎 竹内 一朗 清水 泰岳 新井 勝大 大矢 幸弘 国際診療ガイドラインに基づいて治療を行った小児好酸球性食道炎の2症例 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 590 590 20191000 irahara_makoto/misc/39996837 石川 史 宮地 裕美子 福家 辰樹 犬塚 祐介 苛原 誠 豊國 賢治 西村 幸士 齋藤 麻耶子 佐藤 未織 山本 貴和子 野村 伊知郎 成田 雅美 中尾 寛 吉田 美智子 庄司 健介 大矢 幸弘 緑膿菌による慢性骨髄炎の治療中に複数の抗菌薬による過敏症が疑われ，ニューキノロン系薬の内服試験により治療薬の選択肢を確保できた1例 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 618 618 20191000 irahara_makoto/misc/39996836 西村 幸士 福家 辰樹 犬塚 祐介 豊國 賢治 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 山本 貴和子 野村 伊知郎 大矢 幸弘 多種食物除去療法および原因食物の特定が症状改善に有効であった好酸球性胃腸炎の1例 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 627 627 20191000 irahara_makoto/misc/39996835 宮城 俊雅 福家 辰樹 荻田 博也 木口 智之 犬塚 祐介 豊國 賢治 西村 幸士 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 樺島 重憲 山本 貴和子 野村 伊知郎 大矢 幸弘 アーモンドアレルギー診断における皮膚プリックテストの有用性 (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 647 647 20191000 irahara_makoto/misc/39996829 福家 辰樹 宮地 裕美子 犬塚 祐介 豊國 賢治 西村 幸士 石川 史 苛原 誠 佐藤 未織 齋藤 麻耶子 山本 貴和子 大矢 幸弘 斎藤 博久 閾値分布モデルを用いた特異的IgEによる食物経口負荷試験における負荷量設定の試み (一社)日本小児アレルギー学会 日本小児アレルギー学会誌 1882-2738 33 4 542 542 20191000 irahara_makoto/misc/39996841 豊國 賢治 宮地 裕美子 犬塚 祐介 西村 幸士 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 山本 貴和子 福家 辰樹 野村 伊知郎 大矢 幸弘 気管支喘息 吸入指導 加圧噴霧式定量吸入器+スペーサーによる吸入手技を習得できた1歳6ヵ月男児例 (一社)日本小児臨床アレルギー学会 日本小児臨床アレルギー学会誌 2432-9835 17 2 248 248 20190700 irahara_makoto/misc/39996840 島田 真実 豊國 賢治 宮地 裕美子 山本 貴和子 犬塚 祐介 西村 幸士 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 福家 辰樹 野村 伊知郎 大矢 幸弘 子どもの特性を生かしたプロのサポート 児の特性を活かしてスキンケア手技の獲得に成功したADHD合併アトピー性皮膚炎の男児例 (一社)日本小児臨床アレルギー学会 日本小児臨床アレルギー学会誌 2432-9835 17 2 258 258 20190700 irahara_makoto/misc/41580036 苛原 誠 福家 辰樹 犬塚 祐介 豊國 賢治 西村 幸士 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 山本 貴和子 成田 雅美 野村 伊知郎 大矢 幸弘 小児気管支喘息の病態・疫学・診断 9歳児におけるダニ・スギへの感作と抗原増加時期における呼気NO値の関係 (一社)日本アレルギー学会 アレルギー 0021-4884 68 4-5 515 515 20190500 irahara_makoto/misc/39996871 宮地 裕美子 成田 雅美 犬塚 祐介 豊國 賢治 西村 幸士 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 山本 貴和子 福家 辰樹 野村 伊知郎 大矢 幸弘 経口免疫療法:より安全で有効な解除を目指して 幼児期の食物アレルギー児における経口免疫療法の有効性と安全性 (一社)日本アレルギー学会 アレルギー 0021-4884 68 4-5 502 502 20190500 irahara_makoto/misc/39996842 西村 幸士 福家 辰樹 宮地 裕美子 犬塚 祐介 豊國 賢治 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 山本 貴和子 成田 雅美 野村 伊知郎 大矢 幸弘 経口免疫療法中,異食症により発見された好酸球性胃腸炎の1例 (一社)日本アレルギー学会 アレルギー 0021-4884 68 4-5 582 582 20190500 irahara_makoto/misc/39996828 豊國 賢治 福家 辰樹 犬塚 祐介 西村 幸士 苛原 誠 石川 史 佐藤 未織 齋藤 麻耶子 宮地 裕美子 山本 貴和子 野村 伊知郎 成田 雅美 大矢 幸弘 食物アレルギーの診断と新規アレルゲンコンポーネント 当院でのクルミアレルギーの臨床的特徴とJug r 1特異的IgE検査の有用性の検討 (一社)日本アレルギー学会 アレルギー 0021-4884 68 4-5 534 534 20190500 irahara_makoto/misc/39996872 成田 雅美 苛原 誠 石川 史 岩間 元子 佐藤 未織 宮地 裕美子 稲垣 真一郎 宮田 真貴子 齋藤 麻耶子 山本 貴和子 須田 友子 福家 辰樹 野村 伊知郎 大矢 幸弘 重症化したアレルギー疾患患者の背景因子の検討 日本小児アレルギー学会 日本小児アレルギー学会誌 0914-2649 32 3 579 579 20180800 irahara_makoto/misc/39996873 稲垣 真一郎 成田 雅美 濱崎 雄大 中村 達朗 石川 史 苛原 誠 佐藤 未織 三井 元子 齋藤 麻耶子 宮田 真貴子 宮地 裕美子 山本 貴和子 福家 辰樹 野村 伊知郎 村田 幸久 大矢 幸弘 小児食物アレルギー患者の免疫療法効果予測としてのプロスタグランジンD2尿中代謝産物の有用性 (一社)日本アレルギー学会 アレルギー 0021-4884 67 4-5 589 589 20180500 irahara_makoto/misc/39892865 苛原 誠 木戸 博 アレルギー疾患の診断，治療，予防に向けた新規高性能蛋白チップの臨床応用 (有)科学評論社 臨床免疫・アレルギー科 1881-1930 66 5 504 510 20161100 JSA/WAO Joint Congress 2020 Best speaker賞 20200900