type: misc

label: url

en: The Biased Activities of Prostanoids and Their Receptors: Review and Beyond.

en: Since the discovery of β-arrestin, a new concept/viewpoint has arisen in G-protein coupled receptor (GPCR)-mediated signaling. The Lock and Key concept of GPCR was previously recognized as basically a single- or mono-originated pathway activated from a single receptor. However, the new concept/viewpoint allows for many- or more-than-one-originated pathways activated from a single receptor; namely, biased activities. It is well-recognized that prostanoids exhibit preferences for their corresponding cognate receptors, while promiscuous cross-reactivities have also been reported among endogenous prostanoids and their receptor family. However, of particular interest, such cross-reactivities have led to reports of their physiologically significant roles. Thus, this review discusses and considers that the endogenous prostanoids are not showing random cross-reactivities but what are showing important physiological and pathological activities as biased ligands. Moreover, why and how the biased activities are evoked by endogenous structurally similar prostanoid ligands are discussed. Furthermore, when the biased activities of endogenous prostanoids first arose is also discussed and considered. These biased activities of endogenous prostanoids are also discussed from the perspective that they may provide many benefits and/or disadvantages for all living things, any-where on this planet, who/which are utilizing, had utilized, and will utilize the prostanoids and their receptor system, as a marked driving force for evolution.

en: Biological & Pharmaceutical Bulletin

ja: Biological & Pharmaceutical Bulletin


en: Foreword.

ja: Foreword.


en: 旬の研究紹介「バイアス・リガンドが受容体を翻弄する?」

ja: 旬の研究紹介「バイアス・リガンドが受容体を翻弄する?」

en: 医歯薬学研究部だより

ja: 医歯薬学研究部だより


en: 研究室へようこそ「治癒力のメカニズムを探る生命探求の世界へ」

ja: 研究室へようこそ「治癒力のメカニズムを探る生命探求の世界へ」

en: とくTalk

ja: とくTalk


en: The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling.

en: The lipid mediator prostanoids consist of prostaglandins and thromboxanes, and are synthesized from arachidonic acid by the action of cyclooxygenase. There are five major prostanoids, including prostaglandin E2 (PGE2), and they are involved in a variety of biological responses such as inflammation, allergy, parturition, and tumorigenesis. These prostanoids exert their effects via activation of their cognate G protein coupled receptors, e.g., E-type prostanoid (EP) receptors for PGE2. The EP receptors are composed of four subtypes, namely EP1 to EP4. Here, breakthroughs in the last dozen years of research are introduced, with a special focus on some important findings of EP4 receptor-mediated signaling and the signaling associated with cancer development, particularly in colon cancer.


en: [Novel anti-cancer effects of indomethacin: exploring the cyclooxygenase-inhibition-independent effects].

ja: インドメタシンの新たな抗がん機構の解明:シクロオキシゲナーゼ阻害非依存的作用の探求.

en: Folia Pharmacologica Japonica

ja: 日本薬理学雑誌


en: Assessment of constitutive activity in E-type prostanoid receptors.

en: The potential for G-protein-coupled receptors (GPCRs) to show constitutive activity is emerging as one of the fundamental properties of GPCRs signal transduction. Indeed, of the four subtypes of E-type prostanoid (EP) receptors, the EP3 and EP4 subtypes show constitutive activity in addition to their innate ligand-dependent activation of signaling pathways. The constitutive activity of the EP3 and EP4 receptor subtypes was discovered during the initial characterizations of these receptors and may be important for setting the basal level of cellular tone in the given signaling pathway. This chapter introduces some of the methods that can be used to study the constitutive activity of the EP receptors.

en: Methods in Enzymology

ja: Methods in Enzymology


en: Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?

en: Trends in Pharmacological Sciences

ja: Trends in Pharmacological Sciences


en: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

misc_type: others


en: インドメタシンの新たな抗癌機構の解明 : シクロオキシゲナーゼ阻害非依存的作用の探究．

en: Chiba Medical Journal

ja: 千葉医学雑誌