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Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical NutritionMedical NutritionDepartment of Public Health and Applied Nutrition
Tokushima UniversityGraduate School of Nutrition and BiosciencesHuman Nutrition
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Research Activity

Her Web Page

Field of Study

Food Science

Subject of Study

制がん効果を有する食品成分の探索とその作用機序の解明, エフェロサイトーシスを活性化する食品成分の探索とその作用機序の解明

Book / Paper

Academic Paper (Judged Full Paper):

1. Ayano Satoh, Mitsuko Hayashi-Nishino, Takuto Shakuno, Junko Masuda, Mayuko Koreishi, Runa Murakami, Yoshimasa Nakamura, Toshiyuki Nakamura, Naomi Kanoh, Yasuko Honjo, Joerg Malsam, Sidney Yu and Kunihiko Nishino :
The Golgin Protein Giantin Regulates Interconnections Between Golgi Stacks,
Frontiers in Cell and Developmental Biology, Vol.7, 160, 2019.
(Tokushima University Institutional Repository: 114496,   DOI: 10.3389/fcell.2019.00160,   Elsevier: Scopus)
2. Naomi Kanoh, Kunisue Narumi, Myojin Takumi, Chino Ayako, Munemasa Shintaro, Murata Yoshiyuki, Satoh Ayano, Moriya Hisao and Nakamura Yoshimasa :
Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12,
Scientific Reports, Vol.9, 8866, 2019.
(Tokushima University Institutional Repository: 113410,   DOI: 10.1038/s41598-019-45248-2,   PubMed: 31222108,   Elsevier: Scopus)
3. Naomi Kanoh, Yumi Kunimoto, Daisuke Takemoto, Yoshiko Ono, Hiroshi Shibata, Kohta Ohnishi and Yoshichika Kawai :
Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells.,
Journal of Agricultural and Food Chemistry, 2019.
(Tokushima University Institutional Repository: 113271,   DOI: 10.1021/acs.jafc.8b07227,   PubMed: 30951310)
4. Yue Tang, Sho Naito, Naomi Kanoh, Seiji Ogawa, Shu Yamaguchi, Beiwei Zhu, Yoshiyuki Murata and Yoshimasa Nakamura :
Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells.,
Journal of Biochemical and Molecular Toxicology, Vol.32, No.6, e22054, 2018.
(DOI: 10.1002/jbt.22054,   PubMed: 29667773,   Elsevier: Scopus)
5. Xiaoyang Liu, Naomi Kanoh, Yujia Liu, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata and Yoshimasa Nakamura :
Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells.,
Bioscience, Biotechnology, and Biochemistry, Vol.81, No.11, 2212-2215, 2017.
(DOI: 10.1080/09168451.2017.1374830,   PubMed: 28934922,   Elsevier: Scopus)
6. Yujia Liu, Momoko Yamanaka, Naomi Kanoh, Xiaoyang Liu, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata and Yoshimasa Nakamura :
Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells.,
Food and Chemical Toxicology, Vol.108, No.Pt A, 305-313, 2017.
(DOI: 10.1016/j.fct.2017.08.016,   PubMed: 28821405,   Elsevier: Scopus)
7. Xiaoyang Liu, Chiaki Takano, Tomomi Shimizu, Shintaro Yokobe, Naomi Kanoh, Beiwei Zhu, Toshiyuki Nakamura, Shintaro Munemasa, Yoshiyuki Murata and Yoshimasa Nakamura :
Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells.,
Biochemical and Biophysical Research Communications, Vol.491, No.1, 209-216, 2017.
(DOI: 10.1016/j.bbrc.2017.07.078,   PubMed: 28712871,   Elsevier: Scopus)
8. Yue Tang, Sayaka Nakashima, Shunya Saiki, Yui Myoi, Naomi Kanoh, Shoko Kuwazuru, Beiwei Zhu, Hitoshi Ashida, Yoshiyuki Murata and Yoshimasa Nakamura :
3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides.,
Food Research International, Vol.89, No.Pt 1, 716-723, 2016.
(DOI: 10.1016/j.foodres.2016.09.034,   PubMed: 28460970)
9. Naomi Kanoh, D-X Hou, S Munemasa, Y Murata and Y Nakamura :
Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells.,
Cell Death & Disease, Vol.5, 2014.
(DOI: 10.1038/cddis.2014.495,   PubMed: 25412312)
10. Yue Tang, Naomi Kanoh, Motoko Yoshimoto, Beiwei Zhu, Yoshiyuki Murata and Yoshimasa Nakamura :
Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells.,
Bioscience, Biotechnology, and Biochemistry, Vol.79, No.1, 159-163, 2014.
(DOI: 10.1080/09168451.2014.963503,   PubMed: 25253661)
11. Yoshimasa Nakamura, Takeshi Ishii, Naomi Kanoh and Yoshiyuki Murata :
Thiol modification by bioactivated polyphenols and its potential role in skin inflammation.,
Bioscience, Biotechnology, and Biochemistry, Vol.78, No.6, 1067-1070, 2014.
(DOI: 10.1080/09168451.2014.905190,   PubMed: 25036136)
12. Hang Qi, Naomi Kanoh, Beiwei Zhu, Yoshiyuki Murata and Yoshimasa Nakamura :
(-)-Epigallocatechin-3-gallate ameliorates photodynamic therapy responses in an in vitro T lymphocyte model.,
Phytotherapy Research, Vol.28, No.10, 1486-1491, 2014.
(DOI: 10.1002/ptr.5152,   PubMed: 24700514)
13. Hang Qi, Qian Wu, Naomi Kanoh, Shunya Saiki, Beiwei Zhu, Yoshiyuki Murata and Yoshimasa Nakamura :
Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells.,
Journal of Biochemical and Molecular Toxicology, Vol.28, No.4, 167-173, 2014.
(DOI: 10.1002/jbt.21549,   PubMed: 24488945)
14. Y. Tang, Naomi Kanoh, H. Qi, B. Zhu and Y. Murata :
Tea catechins inhibit cell proliferation through hydrogen peroxide-dependent and -independent pathways in human T lymphocytic leukemia Jurkat cells.,
Food Science and Technology Research, Vol.20, No.6, 1245-1249, 2014.
(DOI: 10.3136/fstr.20.1245)
15. Hang Qi, Beiwei Zhu, Naomi Kanoh, Yuko Shin, Yoshiyuki Murata and Yoshimasa Nakamura :
Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.,
Food and Chemical Toxicology, Vol.50, No.6, 1841-1847, 2012.
(DOI: 10.1016/j.fct.2012.03.011,   PubMed: 22440610)
16. Naomi Kanoh, Masashi Okuhira, Chiharu Tsutsui, Yoshiyuki Murata and Yoshimasa Nakamura :
Cytotoxicity of benzyl isothiocyanate in normal renal proximal tubular cells and its modulation by glutathione.,
Journal of Agricultural and Food Chemistry, Vol.60, No.7, 1887-1892, 2012.
(DOI: 10.1021/jf2052042,   PubMed: 22296293)
17. Naomi Kanoh, Tomomi Shimizu, Noriyuki Miyoshi, Yoshiyuki Murata and Yoshimasa Nakamura :
-Tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate.,
Bioscience, Biotechnology, and Biochemistry, Vol.76, No.2, 381-383, 2012.
(DOI: 10.1271/bbb.110665,   PubMed: 22313765)

Academic Paper (Unrefereed Paper):

1. R. Sakai, S. Yokobe, Naomi Kanoh, N. Miyoshi and Y. Murata :
Luteolin overcomes resistance to benzyl isothiocyanate-induced apoptosis in human colorectal cancer HCT-116 cells.,
Journal of Food and Drug Analysis, Vol.20, No.Suppl., 389-393, 2012.
(DOI: 10.38212/2224-6614.2122,   Elsevier: Scopus)

Review, Commentary:

1. Toshiyuki Nakamura, Naomi Kanoh and Yoshimasa Nakamura :
Physiological relevance of covalent protein modification by dietary isothiocyanates.,
Journal of Clinical Biochemistry and Nutrition, Vol.62, No.1, 11-19, Dec. 2017.
(DOI: 10.3164/jcbn.17-91,   PubMed: 29371751)

Proceeding of International Conference:

1. Naomi Kanoh, Yuki Hashimoto, Haruka Yamamoto and Miyuki Uemura :
The effects of resveratrol and piceid on macrophage efferocytosis,
ICoFF2019, 兵庫県神戸市, Dec. 2019.
2. Naomi Kanoh, Nuka Erika, Mao Aoki, Kotono Noguchi, Miyuki Uemura, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Kohta Ohnishi and Yoshichika Kawai :
Analysis of food-derived nucleic acids and their effects on claudin-4 mRNA expression in differentiated Caco-2 models,
ICoFF2019, Dec. 2019.
3. Maiko SAKAI, Kohta Ohnishi, Teppei FUKUDA, Masashi Masuda, Naomi Kanoh, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
mTORC2 signaling is critical for lysosomal activation by isorhamnetin treatment in J774.1.,
FAOPS2019, Mar. 2019.

Proceeding of Domestic Conference:

1. HASHIMOTO Yuki, Haruka Yamamoto, Akiko Suzuki and Naomi Kanoh :
Resveratrol及び piceidはマクロファージによるエフェロサイトーシスとオプソニン分泌を増強する,
2020年度日本フードファクター学会・日本農芸化学会西日本支部 合同大会, Nov. 2020.
2. Naomi Kanoh, Nuka Erika, Mao Aoki, 南 琴乃, 関口 博太, 須藤 慶太, 宇住 晃治 and 河合 慶親 :
食品由来核酸の分析と腸管バリア機能への作用,
第72回日本栄養・食糧学会大会, May 2018.
3. Naomi Kanoh :
感動を原動力とした研究人生と研究テーマの模索状況,
フードサイエンスフォーラム 第23回学術集会, Sep. 2017.
4. Naomi Kanoh, 國末 成美, 宗正 晋太郎, 村田 芳行, Yoshichika Kawai, 佐藤 あやの, 守屋 央朗 and 中村 宜督 :
食品成分ベンジルイソチオシアネートによる動原体を標的とした大腸がん細胞増殖阻害作用,
日本農芸化学会2017年度大会, Mar. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 食品成分による染色体分配機構を標的とした制がん効果に関する研究 (Project/Area Number: 19K15789 )
  • The comprehensive identification of transcription factors associated with anti-atherosclerotic effects of polyphenols and the clarification of the mechanisms (Project/Area Number: 17K17923 )
  • Search by Researcher Number (30780267)