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Tokushima University > Research Clusters > Research Clusters (Registered) > 1903004 高効率分解処理システム構築のための生分解性高機能バイオプラスチックの創製と評価 >
Tokushima University > Graduate School of Nutrition and Biosciences > Human Nutrition >
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Research Activity

Field of Study

Functional Food Science

Subject of Study

食品成分によるタンパク質品質管理機構の制御 (autophagy, chemical analysis, 食品成分)

Book / Paper

Book:

1. Kohta Ohnishi :
'Diet' & autophagy,
YODOSHA CO., LTD., Jun. 2020.

Academic Paper (Judged Full Paper):

1. Masashi Masuda, Hironori Yamamoto, Yuichiro Takei, Otoki Nakahashi, Yuichiroh Adachi, Kohta Ohnishi, Hirokazu Ohminami, Hisami Yamanaka-Okumura, Hiroshi Sakaue, Makoto Miyazaki, Eiji Takeda and Yutaka Taketani :
All-trans retinoic acid reduces the transcriptional regulation of intestinal sodium-dependent phosphate co-transporter gene (Npt2b).,
The Biochemical Journal, Vol.477, No.4, 817-831, 2020.
(Tokushima University Institutional Repository: 114417,   DOI: 10.1042/BCJ20190716,   PubMed: 32016357)
2. Maiko Sakai, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Okumura, Taichi Hara and Yutaka Taketani :
Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner.,
Bioscience, Biotechnology, and Biochemistry, 2020.
(DOI: 10.1080/09168451.2020.1727309,   PubMed: 32046625,   Elsevier: Scopus)
3. Yuki Niida, Masashi Masuda, Yuichiro Adachi, Aika Yoshizawa, Hirokazu Ohminami, Yuki Mori, Kohta Ohnishi, Hisami Okumura, Takayuki Uchida, Takeshi Nikawa, Hironori Yamamoto, Makoto Miyazaki and Yutaka Taketani :
Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease,
Journal of Clinical Biochemistry and Nutrition, Vol.67, No.2, 179-187, 2020.
(DOI: 10.3164/jcbn.20-24,   CiNii: 130007894915)
4. Cindy VALENTINE, Kohta Ohnishi, Kazuhiro IRIE and Akira MURAKAMI :
Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells.,
Journal of Clinical Biochemistry and Nutrition, Vol.65, No.2, 91-98, 2019.
(DOI: 10.3164/jcbn.19-7,   PubMed: 31592057)
5. Naomi Kanoh, Yumi Kunimoto, Daisuke Takemoto, Yoshiko Ono, Hiroshi Shibata, Kohta Ohnishi and Yoshichika Kawai :
Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells.,
Journal of Agricultural and Food Chemistry, 2019.
(Tokushima University Institutional Repository: 113271,   DOI: 10.1021/acs.jafc.8b07227,   PubMed: 30951310)
6. Shiori Fukuda-Tatano, Hironori Yamamoto, Otoki Nakahashi, Ryouhei Yoshikawa, Mayu Hayashi, Maki Kishimoto, Yukiko Imi, Hisami Okumura, Kohta Ohnishi, Masashi Masuda and Yutaka Taketani :
Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods.,
Calcified Tissue International, Vol.104, No.6, 667-678, 2019.
(Tokushima University Institutional Repository: 113367,   DOI: 10.1007/s00223-019-00525-0,   PubMed: 30671592)
7. Erika Nuka, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols.,
PLoS ONE, Vol.13, No.9, e0204229, 2018.
(Tokushima University Institutional Repository: 114342,   DOI: 10.1371/journal.pone.0204229,   PubMed: 30248132)
8. Hsu L. Cynthia, Lee X. Elian, Gordon L. Kara, Paz A. Edwin, Shen Wen-Chuan, Kohta Ohnishi, Meisenhelder Jill, Hunter Tony and Spada R. La Albert :
MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB,
Nature Communications, Vol.9, No.1, 942, 2018.
(DOI: 10.1038/s41467-018-03340-7,   PubMed: 29507340)
9. Audrey S. Dickey, Dafne N. Sanchez, Martin Arreola, Kunal R. Sampat, Weiwei Fan, Nicolas Arbez, Sergey Akimov, Michael Kanegan J. Van, Kohta Ohnishi, Stephen K. Gilmore-Hall, April L. Flores, Janice M. Nguyen, Nicole Lomas, Cynthia L. Hsu, Donald C. Lo, Christopher A. Ross, Eliezer Masliah, Ronald M. Evans and Albert Spada R. La :
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.,
Science Translational Medicine, Vol.9, No.419, eaal2332, 2017.
(DOI: 10.1126/scitranslmed.aal2332,   PubMed: 29212711,   Elsevier: Scopus)

Proceeding of International Conference:

1. Naomi Kanoh, Nuka Erika, Mao Aoki, Kotono Noguchi, Miyuki Uemura, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Kohta Ohnishi and Yoshichika Kawai :
Analysis of food-derived nucleic acids and their effects on claudin-4 mRNA expression in differentiated Caco-2 models,
ICoFF2019, Dec. 2019.
2. Kohta Ohnishi, Moe FUJIMOTO, Maiko SAKAI, Teppei FUKUDA, Aika OHNISHI, Hirokazu Ohminami, Masashi Masuda, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Exploration of bioactive food factors for the control of autophagy flux,
The 7th International Conference on Food Factors, Dec. 2019.
3. Maiko SAKAI, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Okumura, Taichi HARA and Yutaka Taketani :
Elucidation of the molecular mechanism underlying lysosomal activation in J774.1 cells by isorhamnetin treatment,
The 7th International Conference on Food Factors, Dec. 2019.
4. Oda Naoko, Sugihara Kohei, Miho Ikeda, Yuho Higashimura, Takashi Uebansou, Kohta Ohnishi, Hirokazu Ohminami, Masashi Masuda, Hisami Okumura and Yutaka Taketani :
Dietary phosphate disturbs of gut microbiome in mice.,
American Society of Nephrolody Kidney Week 2019, Washington, D.C., Nov. 2019.
5. Fukuda-Tatano Shiori, Hironori Yamamoto, Nakahashi Otoki, Yoshikawa Ryouhei, Hayashi Mayu, Kishimoto Maki, Yukiko Imi, Yamanaka-Okumura Hisami, Kohta Ohnishi, Masashi Masuda and Yutaka Taketani :
Regulation of α-klotho Expression by Dietary Phosphate During Growth Periods,
ASBMR 2019 Annual Meeting, Sep. 2019.
6. Masashi Masuda, Hironori Yamamoto, Yuichiro Adachi, Kohta Ohnishi, Hirokazu Ohminami, Hisami Okumura, Makoto Miyazaki, Eiji Takeda and Yutaka Taketani :
All-trans-retinoic-acid reduces intestinal phosphate uptake by the transcriptional regulation of sodium-dependent phosphate co-transporter gene (Npt2b).,
ASBMR 2019 Annual Meeting, Sep. 2019.
7. Maiko SAKAI, Kohta Ohnishi, Teppei FUKUDA, Masashi Masuda, Naomi Kanoh, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
mTORC2 signaling is critical for lysosomal activation by isorhamnetin treatment in J774.1.,
FAOPS2019, Mar. 2019.
8. Yoshida Risa, Masashi Masuda, Mori Yuki, Niida Yuki, Adachi Yuichiro, Kohta Ohnishi, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Sulforaphane induces lipolysis via lipophagy in mouse adipocyte,
Kern Lipid Conference, Vail, Colorado, Aug. 2018.
9. Nuka Erika, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
Signaling pathways of ATP and adenosine could be anti-inflammatory targets of polyphenols,
8th International Conference on Polyphenols and Health, Oct. 2017.

Proceeding of Domestic Conference:

1. Hironori Yamamoto, Mari Tajiri, Otoki Nakahashi, Masashi Masuda, Hirokazu Ohminami, Kohta Ohnishi, Eiji Takeda and Yutaka Taketani :
糖尿病時におけるビタミンD・カルシウム代謝異常の分子機構の解明,
The 74th Annual Meeting of Japan Society of Nutrition and Food Science, Apr. 2020.
2. 矢野 敏史, 山越 正汰, 太田 智絵, 宇都 拓洋, Maiko Sakai, Kohta Ohnishi and hara Taichi :
新規機能性食品によるmTORC1シグナルに依存しないオートファジーの活性化機構と作用成分,
The 74th Annual Meeting of Japan Society of Nutrition and Food Science, Apr. 2020.
3. Sakai Maiko, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Okumura, Hara Taichi and Yutaka Taketani :
Elucidation of the molecular mechanism of lysosomal activation through mTORC2, a nutrient-sensitive signaling,
The 74th Annual Meeting of Japan Society of Nutrition and Food Science, Apr. 2020.
4. Yamakoshi Shota, Sakai Maiko, Fujimoto Moe, Kohta Ohnishi and Hara Taichi :
Elucidation of a starvation-independent autophagy by food,
日本農芸化学会2020年度大会, Mar. 2020.
5. Fukuda Teppei, Kohta Ohnishi, Masashi Masuda, Matsuzaki Yasunori, Konno Ayumu, Fujimoto Moe, Ohnishi Aika, sakai maiko, Hirokazu Ohminami, Hisami Okumura, Hara Taichi, Hirai Hirokazu and Yutaka Taketani :
Establishment of an in vivo assay system for monitoring autophagy utilizing NIR fluorescence imaging,
日本農芸化学会2020年度大会, Mar. 2020.
6. Maiko Sakai, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Okumura, Hara Taichi and Yutaka Taketani :
mTORC2 signaling controls the lysosomal activity in J774.1 macrophage-like cell.,
日本農芸化学会2020年度大会, Mar. 2020.
7. Miho Ikeda, Naoko Oda, Takashi Uebansou, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Hisami Okumura and Yutaka Taketani :
高リン食が腸内環境を介して慢性腎臓病に与える影響,
第23回日本病態栄養学会年次集会, Jan. 2020.
8. Yuuki Niida, Masashi Masuda, Aika Yoshizawa, Yuichiroh Adachi, Kohta Ohnishi, Hirokazu Ohminami, Takayuki Uchida, Hisami Okumura, Takeshi Nikawa, Hironori Yamamoto and Yutaka Taketani :
慢性腎臓病による骨格筋の脂肪酸代謝異常を介した脂肪毒性(Liptoxicity)は筋委縮(サルコペニア) を惹起する,
第23回日本病態栄養学会年次集会, Jan. 2020.
9. Kohta Ohnishi :
Is autophagy regulatable by 'Diet'?,
レドックス・ライフイノベーション第170委員会 20周年記念若手シンポジウム, Jan. 2020.
10. Yuki Kamei, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Hisami Okumura and Yutaka Taketani :
小児期において血中 Fetuin-A 濃度とリン濃度は相関する,
第52回日本栄養・食糧学会 中国・四国支部会, Oct. 2019.
11. Yuki Mori, Masashi Masuda, Risa Yoshida, Saki Aoyagi, Kohta Ohnishi, Hirokazu Ohminami, Hisami Okumura, Takeshi Nikawa, 濱田 広一郎 and Yutaka Taketani :
レチノイン酸によるリポファジーを介した脂肪分解への影響,
第52回日本栄養・食糧学会 中国•四国支部大会, Oct. 2019.
12. Maiko SAKAI, Kohta Ohnishi, Hirokazu Ohminami, Masashi Masuda, Hisami Okumura and Yutaka Taketani :
mTORC2 signaling controls the lysosomal activity by regulating of gene expressions in macrophage-like cell line.,
第92回日本生化学会大会, Sep. 2019.
13. Yuuki Niida, Masashi Masuda, Aika Yoshizawa, Yuichiroh Adachi, Kohta Ohnishi, Hirokazu Ohminami, Takayuki Uchida, Hisami Okumura, Takeshi Nikawa, Hironori Yamamoto and Yutaka Taketani :
慢性腎臓病モデルラットの骨格筋における脂肪酸代謝異常が及ぼす筋萎縮への影響,
第66回日本栄養改善学会学術集会, Sep. 2019.
14. Keiko Satoh, Masashi Masuda, 佐々木 晧平, Hirokazu Ohminami, Kohta Ohnishi, Hisami Okumura, Hironori Yamamoto and Yutaka Taketani :
All-trans retinoic acidによるヒストン修飾を介したFGF23発現への影響,
第7回日本腎栄養代謝研究会, Jul. 2019.
15. Shiori Tatano, Hironori Yamamoto, Otoki Nakahashi, Ryohei Yoshikawa, Mayu Hayashi, Maki Kishimoto, Yukiko Imi, Hisami Okumura, Masashi Masuda, Kohta Ohnishi and Yutaka Taketani :
成長期における短期的・長期的食餌性リン負荷がFGF23/α-klothoシグナルに及ぼす影響,
日本ビタミン学会第71回大会, Jun. 2019.
16. Yuichiroh Adachi, Masashi Masuda, Yuuki Niida, Kohta Ohnishi, Takayuki Uchida, Hisami Okumura, Hironori Yamamoto, Takeshi Nikawa and Yutaka Taketani :
レチノイン酸による小胞体ストレス感受性の影響,
日本ビタミン学会第71回大会, Jun. 2019.
17. Keiko Satoh, Masashi Masuda, Yuichiroh Adachi, Kohta Ohnishi, Hisami Okumura, Hironori Yamamoto and Yutaka Taketani :
All-trans retinoic acidによるヒストン修飾を介したFGF23発現への影響,
第73回日本栄養・食糧学会大会, May 2019.
18. Moe Fujimoto, Kohta Ohnishi, Maiko Sakai, Teppei Fukuda, Aika Ohnishi, Masashi Masuda, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Exploration of bioactive food factors for the control of autophagy flux,
日本農芸化学会2019年度大会, Mar. 2019.
19. 足立 雄一郎, Masashi Masuda, 新井田 裕樹, Kohta Ohnishi, Takayuki Uchida, Hisami Okumura, Takeshi Nikawa and Yutaka Taketani :
小胞体ストレス誘導下におけるレチノイン酸の影響,
第51回 日本栄養・食糧学会 中国・四国支部大会, Nov. 2018.
20. Maiko Sakai, Kohta Ohnishi and Yoshichika Kawai :
イソラムネチンはmTORC2シグナル依存的にマクロファージ様細胞におけるリソソーム活性を亢進する,
第23回日本フードファクター学会学術集会, Sep. 2018.
21. 吉田 里沙, Masashi Masuda, 森 優樹, 新井田 裕樹, 足立 雄一郎, Kohta Ohnishi, Yoshichika Kawai, Takeshi Nikawa, 山本 浩範 and Yutaka Taketani :
スルフォラファンのリポファジーを介した脂肪分解効果,
Food Congress 2018, Sep. 2018.
22. Yuuki Niida, Masashi Masuda, Aika Yoshizawa, Yuichiroh Adachi, Takayuki Uchida, Kohta Ohnishi, Yoshichika Kawai, Takeshi Nikawa, Hironori Yamamoto and Yutaka Taketani :
慢性腎臓病に伴う骨格筋の飽和脂肪酸蓄積はオートファジー不全を介して筋萎縮を誘発する,
日本ビタミン学会第70回大会(高槻現代劇場), Jun. 2018.
23. Saya Okamoto, Maya Daioku, Kohta Ohnishi and Yoshichika Kawai :
一重項酸素によって生じるリノール酸10-/12-リノール酸ヒドロペルオキシド異性体の単離とその分解物の探索,
第71回日本酸化ストレス学会/第18回日本NO学会 合同学術集会, May 2018.
24. Risa Yoshida, Yuuki Niida, Yuichiroh Adachi, 酒井 晶子, Hisami Okumura, Kohta Ohnishi, Takayuki Uchida, Yoshichika Kawai, Hironori Yamamoto, Takeshi Nikawa, Yutaka Taketani and Masashi Masuda :
スルフォラファンのリポファジーを介した脂肪分解効果,
第72回日本栄養・食糧学会大会(岡山県立大学), May 2018.
25. Kohta Ohnishi :
食品成分によるオートファジー制御を目指して,
第10回北陸合同バイオシンポジウム, Nov. 2017.
26. Kohta Ohnishi :
サンディエゴに留学して,感じたこと,
フードサイエンスフォーラム 第23回学術集会, Sep. 2017.
27. 額 惠理香, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
アデノシン類によるマクロファージ炎症促進作用に対するポリフェノールの効果,
日本農芸化学会2017年度大会, Mar. 2017.

Et cetera, Workshop:

1. Maiko Sakai, Kohta Ohnishi and Yoshichika Kawai :
マクロファージのリソソーム活性を亢進する食品成分の探索と作用機序の解析,
第257回徳島医学会学術集会(平成30年度夏期), Aug. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Establishment of an in vivo imaging system and novel biomarkers for monitoring autophagy flux (Project/Area Number: 20K19675 )
  • 代謝リモデリングを標的とした心臓リハビリテーション栄養の実現化 (Project/Area Number: 20H04038 )
  • Elucidation of set-point mechanism for phosphate homeostasis and development of a novel therapeutic target for age-related diseases (Project/Area Number: 19H04053 )
  • Exploration of low-molecular-weight markers for the development of the method to measure the autophagic activity (Project/Area Number: 18K14422 )
  • Search for novel secretory biomarkers indicating autophagic activity (Project/Area Number: 26660110 )
  • Search by Researcher Number (80723816)