type: misc

label: url

en: Diversity and differentiation pathways of medullary thymic epithelial cells

ja: 胸腺髄質上皮細胞の多様性と分化経路

en: Clinical Immunology & Allergology

ja: 臨床免疫·アレルギー科


en: The role of thymic epithelium in thymus development and age-related thymic involution.

en: The establishment of an adaptive immune system is critical for protecting our bodies from neoplastic cancers and invading pathogens such as viruses and bacteria. As a primary lymphoid organ, the thymus generates lymphoid T cells that play a major role in the adaptive immune system. T cell generation in the thymus is controlled by interactions between thymocytes and other thymic cells, primarily thymic epithelial cells. Thus, the normal development and function of thymic epithelial cells are important for the generation of immunocompetent and self-tolerant T cells. On the other hand, the degeneration of the thymic epithelium due to thymic aging causes thymic involution, which is associated with the decline of adaptive immune function. Herein we summarize basic and current knowledge of the development and function of thymic epithelial cells and the mechanism of thymic involution. J. Med. Invest. 71 : 29-39, February, 2024.

en: The Journal of Medical Investigation : JMI


en: 胸腺上皮細胞の動態:胎生期での発生，成体での維持，加齢に伴う退縮

ja: 胸腺上皮細胞の動態:胎生期での発生，成体での維持，加齢に伴う退縮

en: 胸腺上皮細胞は，非自己に応答し，自己に寛容なT細胞レパトア形成をになう胸腺微小環境を構築する主要な細胞である．胸腺上皮細胞は，それぞれ皮質と髄質の微小環境を構成する胸腺皮質上皮細胞と胸腺髄質上皮細胞に分類され，これらの上皮細胞は，胎生期に，内胚葉由来の上皮共通前駆細胞から分化する．近年，胸腺上皮細胞の分化と維持，および，胸腺退縮における胸腺上皮細胞の変化について，そのメカニズムが明らかにされつつある．そこで本稿では，これらの胸腺上皮細胞の動態について，最新の知見を紹介する．

en: Inflammation & Immunology

ja: 炎症と免疫