=== Generating (published_papers) ===
=== Generating (misc) ===
=== Generating (research_projects) ===
=== Generating (presentations) ===
==== begin registerFile(/WWW/pub2/data/ERD/person/323108/researchmap/published_papers.jsonl) ====
line:1, {"insert":{"user_id":"B000337767","type":"published_papers","id":"45793419"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/119092","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38466627","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1360581940738928512/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85187799485&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=405400","label":"url"}],"paper_title":{"en":"Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium.","ja":"Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium."},"authors":{"en":[{"name":"Ohigashi Izumi"},{"name":"White Andrea"},{"name":"Yang Mei-Ting"},{"name":"Fujimori Sayumi"},{"name":"Tanaka Yu"},{"name":"Jacques Alison"},{"name":"Kiyonari Hiroshi"},{"name":"Matsushita Yosuke"},{"name":"Turan Sevilay"},{"name":"Kelly Michael"},{"name":"Anderson Graham"},{"name":"Takahama Yousuke"}],"ja":[{"name":"大東 いずみ"},{"name":"White Andrea"},{"name":"Yang Mei-Ting"},{"name":"藤森 さゆ美"},{"name":"Tanaka Yu"},{"name":"Jacques Alison"},{"name":"Kiyonari Hiroshi"},{"name":"Matsushita Yosuke"},{"name":"Turan Sevilay"},{"name":"Kelly Michael"},{"name":"Anderson Graham"},{"name":"Takahama Yousuke"}]},"description":{"en":"Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells (mTECs) include a self-antigen-displaying subset that exhibits genome-wide promiscuous gene expression promoted by the nuclear protein Aire and that resembles a mosaic of extrathymic cells including mucosal tuft cells. An additional mTEC subset produces the chemokine CCL21, thereby attracting positively selected thymocytes from the cortex to the medulla. Both self-antigen-displaying and thymocyte-attracting mTEC subsets are essential for self-tolerance. Here, we identify a developmental pathway by which mTECs gain their diversity in functionally distinct subsets. We show that CCL21-expressing mTECs arise early during thymus ontogeny in mice. Fate-mapping analysis reveals that self-antigen-displaying mTECs, including Aire-expressing mTECs and thymic tuft cells, are derived from CCL21-expressing cells. The differentiation capability of CCL21-expressing embryonic mTECs is verified in reaggregate thymus experiments. These results indicate that CCL21-expressing embryonic mTECs carry a developmental potential to give rise to self-antigen-displaying mTECs, revealing that the sequential conversion of thymocyte-attracting subset into self-antigen-displaying subset serves to assemble functional diversity in the thymus medulla epithelium.","ja":"Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells (mTECs) include a self-antigen-displaying subset that exhibits genome-wide promiscuous gene expression promoted by the nuclear protein Aire and that resembles a mosaic of extrathymic cells including mucosal tuft cells. An additional mTEC subset produces the chemokine CCL21, thereby attracting positively selected thymocytes from the cortex to the medulla. Both self-antigen-displaying and thymocyte-attracting mTEC subsets are essential for self-tolerance. Here, we identify a developmental pathway by which mTECs gain their diversity in functionally distinct subsets. We show that CCL21-expressing mTECs arise early during thymus ontogeny in mice. Fate-mapping analysis reveals that self-antigen-displaying mTECs, including Aire-expressing mTECs and thymic tuft cells, are derived from CCL21-expressing cells. The differentiation capability of CCL21-expressing embryonic mTECs is verified in reaggregate thymus experiments. These results indicate that CCL21-expressing embryonic mTECs carry a developmental potential to give rise to self-antigen-displaying mTECs, revealing that the sequential conversion of thymocyte-attracting subset into self-antigen-displaying subset serves to assemble functional diversity in the thymus medulla epithelium."},"publication_date":"2024-03-11","publication_name":{"en":"eLife","ja":"eLife"},"volume":"Vol.12","starting_page":"RP92552","ending_page":"RP92552","languages":["eng"],"referee":true,"identifiers":{"doi":["10.7554/eLife.92552"],"issn":["2050-084X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"B000337767","type":"published_papers","id":"36183955"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116664","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35042581","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383730","label":"url"}],"paper_title":{"en":"Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development","ja":"Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development"},"authors":{"en":[{"name":"Fujimori Sayumi"},{"name":"Ohigashi Izumi"},{"name":"Abe Hayato"},{"name":"Matsushita Yosuke"},{"name":"Katagiri Toyomasa"},{"name":"Makoto M. Taketo"},{"name":"Yousuke Takahama"},{"name":"Shinji Takada"}],"ja":[{"name":"藤森 さゆ美"},{"name":"大東 いずみ"},{"name":"阿部 勇人"},{"name":"松下 洋輔"},{"name":"片桐 豊雅"},{"name":"Makoto M. Taketo"},{"name":"Yousuke Takahama"},{"name":"Shinji Takada"}]},"description":{"en":"In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in mouse thymic epithelial cells (TECs) disrupts embryonic thymus organogenesis. However, the role of β-catenin in TECs for postnatal T-cell development remains to be elucidated. Here, we analyzed gain-of-function (GOF) and loss-of-function (LOF) of β-catenin highly specific in mouse TECs. We found that GOF of β-catenin in TECs results in severe thymic dysplasia and T-cell deficiency beginning from the embryonic period. By contrast, LOF of β-catenin in TECs reduces the number of cortical TECs and thymocytes modestly and only postnatally. These results indicate that fine-tuning of β-catenin expression within a permissive range is required for TECs to generate an optimal microenvironment to support postnatal T-cell development.","ja":"In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in mouse thymic epithelial cells (TECs) disrupts embryonic thymus organogenesis. However, the role of β-catenin in TECs for postnatal T-cell development remains to be elucidated. Here, we analyzed gain-of-function (GOF) and loss-of-function (LOF) of β-catenin highly specific in mouse TECs. We found that GOF of β-catenin in TECs results in severe thymic dysplasia and T-cell deficiency beginning from the embryonic period. By contrast, LOF of β-catenin in TECs reduces the number of cortical TECs and thymocytes modestly and only postnatally. These results indicate that fine-tuning of β-catenin expression within a permissive range is required for TECs to generate an optimal microenvironment to support postnatal T-cell development."},"publication_date":"2022-01-19","publication_name":{"en":"eLife","ja":"eLife"},"volume":"Vol.11","starting_page":"e69088","ending_page":"e69088","languages":["eng"],"referee":true,"identifiers":{"doi":["10.7554/eLife.69088"],"issn":["2050-084X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"B000337767","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116455","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33555295","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373644","label":"url"}],"paper_title":{"en":"The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection.","ja":"The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection."},"authors":{"en":[{"name":"Ohigashi Izumi"},{"name":"Frantzeskakis Melina"},{"name":"Jacques Alison"},{"name":"Fujimori Sayumi"},{"name":"Ushio Aya"},{"name":"Yamashita Fusano"},{"name":"Ishimaru Naozumi"},{"name":"Yin Da"},{"name":"Cam Margaret"},{"name":"Kelly Michael C"},{"name":"Awasthi Parirokh"},{"name":"Takada Kensuke"},{"name":"Takahama Yousuke"}],"ja":[{"name":"大東 いずみ"},{"name":"Frantzeskakis Melina"},{"name":"Jacques Alison"},{"name":"藤森 さゆ美"},{"name":"牛尾 綾"},{"name":"Yamashita Fusano"},{"name":"石丸 直澄"},{"name":"Yin Da"},{"name":"Cam Margaret"},{"name":"Kelly Michael C"},{"name":"Awasthi Parirokh"},{"name":"高田 健介"},{"name":"高浜 洋介"}]},"description":{"en":"The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.","ja":"The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus."},"publication_date":"2021-04-05","publication_name":{"en":"The Journal of Experimental Medicine","ja":"The Journal of Experimental Medicine"},"volume":"Vol.218","number":"No.4","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1084/jem.20201904"],"issn":["1540-9538"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"B000337767","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115049","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31775054","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=361076","label":"url"}],"paper_title":{"en":"Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.","ja":"Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells."},"authors":{"en":[{"name":"Ohigashi Izumi"},{"name":"Tanaka Yu"},{"name":"Kondou Kenta"},{"name":"Fujimori Sayumi"},{"name":"Kondo Hiroyuki"},{"name":"Palin Amy"},{"name":"Hoffmann Victoria"},{"name":"Kozai Mina"},{"name":"Matsushita Yosuke"},{"name":"Uda Shinsuke"},{"name":"Motosugi Ryo"},{"name":"Hamazaki Jun"},{"name":"Kubota Hiroyuki"},{"name":"Murata Shigeo"},{"name":"Tanaka Keiji"},{"name":"Katagiri Toyomasa"},{"name":"Kosako Hidetaka"},{"name":"Takahama Yousuke"}],"ja":[{"name":"大東 いずみ"},{"name":"Tanaka Yu"},{"name":"近藤 健太"},{"name":"藤森 さゆ美"},{"name":"近藤 博之"},{"name":"Palin Amy"},{"name":"Hoffmann Victoria"},{"name":"Kozai Mina"},{"name":"松下 洋輔"},{"name":"Uda Shinsuke"},{"name":"Motosugi Ryo"},{"name":"Hamazaki Jun"},{"name":"Kubota Hiroyuki"},{"name":"Murata Shigeo"},{"name":"Tanaka Keiji"},{"name":"片桐 豊雅"},{"name":"小迫 英尊"},{"name":"高浜 洋介"}]},"publication_date":"2019-11-26","publication_name":{"en":"Cell Reports","ja":"Cell Reports"},"volume":"Vol.29","number":"No.9","starting_page":"2901","ending_page":"2916.e6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.celrep.2019.10.079"],"issn":["2211-1247"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:5, {"insert":{"user_id":"B000337767","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113696","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31235550","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85070388863&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=359947","label":"url"}],"paper_title":{"en":"TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells","ja":"TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells"},"authors":{"en":[{"name":"Khanom Umme Shahina"},{"name":"Ohigashi Izumi"},{"name":"Fujimori Sayumi"},{"name":"Kondou Kenta"},{"name":"Takada Kensuke"},{"name":"Takahama Yousuke"}],"ja":[{"name":"UMME KHANOM SHAHINA"},{"name":"大東 いずみ"},{"name":"藤森 さゆ美"},{"name":"近藤 健太"},{"name":"高田 健介"},{"name":"高浜 洋介"}]},"description":{"en":"The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. Previous fetal thymus organ culture experiments have indicated that difference in the affinity for thymic TCR/pMHC interactions not only determines thymocyte fate between positive and negative selection, but also affects Ag responsiveness of positively selected thymocytes. In the current study, we examined whether TCR/pMHC affinity during positive selection in the thymus would further affect Ag responsiveness of mature T cells in the periphery. To do so, OVA peptide variants were in vivo administered to TAP1-deficient OT-I/TCR-transgenic mice in which T cell development was otherwise arrested at CD4CD8 thymocytes because of the lack of self-pMHC presentation in thymic APCs. We found that a group of peptide variants induced the transient generation of OT-I CD8 T cells in the thymus and the periphery. We also noticed that the affinity threshold for positive and negative selection detected in adult mice in vivo was higher than that measured in fetal thymus organ culture experiments in vitro. Interestingly, we further found that the affinity for positively selecting peptides proportionally affected TCR responsiveness of peripheral naive CD8 T cells. These results indicate that in vivo administration of a peptide can promote T cell selection in the thymus and the affinity for TCR/pMHC interaction during positive selection fine-tunes Ag responsiveness of peripheral T cells.","ja":"The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. Previous fetal thymus organ culture experiments have indicated that difference in the affinity for thymic TCR/pMHC interactions not only determines thymocyte fate between positive and negative selection, but also affects Ag responsiveness of positively selected thymocytes. In the current study, we examined whether TCR/pMHC affinity during positive selection in the thymus would further affect Ag responsiveness of mature T cells in the periphery. To do so, OVA peptide variants were in vivo administered to TAP1-deficient OT-I/TCR-transgenic mice in which T cell development was otherwise arrested at CD4CD8 thymocytes because of the lack of self-pMHC presentation in thymic APCs. We found that a group of peptide variants induced the transient generation of OT-I CD8 T cells in the thymus and the periphery. We also noticed that the affinity threshold for positive and negative selection detected in adult mice in vivo was higher than that measured in fetal thymus organ culture experiments in vitro. Interestingly, we further found that the affinity for positively selecting peptides proportionally affected TCR responsiveness of peripheral naive CD8 T cells. These results indicate that in vivo administration of a peptide can promote T cell selection in the thymus and the affinity for TCR/pMHC interaction during positive selection fine-tunes Ag responsiveness of peripheral T cells."},"publication_date":"2019-08-15","publication_name":{"en":"The Journal of Immunology","ja":"The Journal of Immunology"},"volume":"Vol.203","number":"No.4","starting_page":"881","ending_page":"887","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4049/jimmunol.1900097"],"issn":["1550-6606"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:6, {"insert":{"user_id":"B000337767","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114781","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29352112","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341541","label":"url"}],"paper_title":{"en":"Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo.","ja":"Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo."},"authors":{"en":[{"name":"Furuya Masayuki"},{"name":"Kikuta Junichi"},{"name":"Fujimori Sayumi"},{"name":"Seno Shigeto"},{"name":"Maeda Hiroki"},{"name":"Shirazaki Mai"},{"name":"Uenaka Maki"},{"name":"Mizuno Hiroki"},{"name":"Iwamoto Yoriko"},{"name":"Morimoto Akito"},{"name":"Hashimoto Kunihiko"},{"name":"Ito Takeshi"},{"name":"Isogai Yukihiro"},{"name":"Kashii Masafumi"},{"name":"Kaito Takashi"},{"name":"Ohba Shinsuke"},{"name":"Chung Ung-Il"},{"name":"Lichtler C. Alexander"},{"name":"Kikuchi Kazuya"},{"name":"Matsuda Hideo"},{"name":"Yoshikawa Hideki"},{"name":"Ishii Masaru"}],"ja":[{"name":"Furuya Masayuki"},{"name":"Kikuta Junichi"},{"name":"藤森 さゆ美"},{"name":"Seno Shigeto"},{"name":"Maeda Hiroki"},{"name":"Shirazaki Mai"},{"name":"Uenaka Maki"},{"name":"Mizuno Hiroki"},{"name":"Iwamoto Yoriko"},{"name":"Morimoto Akito"},{"name":"Hashimoto Kunihiko"},{"name":"Ito Takeshi"},{"name":"Isogai Yukihiro"},{"name":"Kashii Masafumi"},{"name":"Kaito Takashi"},{"name":"Ohba Shinsuke"},{"name":"Chung Ung-Il"},{"name":"Lichtler C. Alexander"},{"name":"Kikuchi Kazuya"},{"name":"Matsuda Hideo"},{"name":"Yoshikawa Hideki"},{"name":"Ishii Masaru"}]},"description":{"en":"Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial-temporal relationship and mode of interaction in vivo remain elusive. Here we show, by using an intravital imaging technique, that mOB and mOC functions are regulated via direct cell-cell contact between these cell types. The mOBs and mOCs mainly occupy discrete territories in the steady state, although direct cell-cell contact is detected in spatiotemporally limited areas. In addition, a pH-sensing fluorescence probe reveals that mOCs secrete protons for bone resorption when they are not in contact with mOBs, whereas mOCs contacting mOBs are non-resorptive, suggesting that mOBs can inhibit bone resorption by direct contact. Intermittent administration of parathyroid hormone causes bone anabolic effects, which lead to a mixed distribution of mOBs and mOCs, and increase cell-cell contact. This study reveals spatiotemporal intercellular interactions between mOBs and mOCs affecting bone homeostasis in vivo.","ja":"Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial-temporal relationship and mode of interaction in vivo remain elusive. Here we show, by using an intravital imaging technique, that mOB and mOC functions are regulated via direct cell-cell contact between these cell types. The mOBs and mOCs mainly occupy discrete territories in the steady state, although direct cell-cell contact is detected in spatiotemporally limited areas. In addition, a pH-sensing fluorescence probe reveals that mOCs secrete protons for bone resorption when they are not in contact with mOBs, whereas mOCs contacting mOBs are non-resorptive, suggesting that mOBs can inhibit bone resorption by direct contact. Intermittent administration of parathyroid hormone causes bone anabolic effects, which lead to a mixed distribution of mOBs and mOCs, and increase cell-cell contact. This study reveals spatiotemporal intercellular interactions between mOBs and mOCs affecting bone homeostasis in vivo."},"publication_date":"2018-01-19","publication_name":{"en":"Nature Communications","ja":"Nature Communications"},"volume":"Vol.9","number":"No.1","starting_page":"300","ending_page":"300","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41467-017-02541-w"],"issn":["2041-1723"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/323108/researchmap/published_papers.jsonl, Uj7NNpMBwbWENEENMDCm) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/323108/researchmap/misc.jsonl) ====
line:1, {"insert":{"user_id":"B000337767","type":"misc","id":"46003257"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=406017","label":"url"}],"paper_title":{"en":"Diversity and differentiation pathways of medullary thymic epithelial cells","ja":"胸腺髄質上皮細胞の多様性と分化経路"},"authors":{"en":[{"name":"Fujimori Sayumi"},{"name":"Ohigashi Izumi"}],"ja":[{"name":"藤森 さゆ美"},{"name":"大東 いずみ"}]},"publication_date":"2024-04-25","publication_name":{"en":"Clinical Immunology & Allergology","ja":"臨床免疫·アレルギー科"},"volume":"Vol.81","number":"No.4","starting_page":"385","ending_page":"390","languages":["jpn"],"identifiers":{"issn":["1881-1930"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"B000337767","type":"misc","id":"46481993"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/119192","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38735722","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=408418","label":"url"}],"paper_title":{"en":"The role of thymic epithelium in thymus development and age-related thymic involution.","ja":"The role of thymic epithelium in thymus development and age-related thymic involution."},"authors":{"en":[{"name":"Fujimori Sayumi"},{"name":"Ohigashi Izumi"}],"ja":[{"name":"藤森 さゆ美"},{"name":"大東 いずみ"}]},"description":{"en":"The establishment of an adaptive immune system is critical for protecting our bodies from neoplastic cancers and invading pathogens such as viruses and bacteria. As a primary lymphoid organ, the thymus generates lymphoid T cells that play a major role in the adaptive immune system. T cell generation in the thymus is controlled by interactions between thymocytes and other thymic cells, primarily thymic epithelial cells. Thus, the normal development and function of thymic epithelial cells are important for the generation of immunocompetent and self-tolerant T cells. On the other hand, the degeneration of the thymic epithelium due to thymic aging causes thymic involution, which is associated with the decline of adaptive immune function. Herein we summarize basic and current knowledge of the development and function of thymic epithelial cells and the mechanism of thymic involution. J. Med. Invest. 71 : 29-39, February, 2024.","ja":"The establishment of an adaptive immune system is critical for protecting our bodies from neoplastic cancers and invading pathogens such as viruses and bacteria. As a primary lymphoid organ, the thymus generates lymphoid T cells that play a major role in the adaptive immune system. T cell generation in the thymus is controlled by interactions between thymocytes and other thymic cells, primarily thymic epithelial cells. Thus, the normal development and function of thymic epithelial cells are important for the generation of immunocompetent and self-tolerant T cells. On the other hand, the degeneration of the thymic epithelium due to thymic aging causes thymic involution, which is associated with the decline of adaptive immune function. Herein we summarize basic and current knowledge of the development and function of thymic epithelial cells and the mechanism of thymic involution. J. Med. Invest. 71 : 29-39, February, 2024."},"publication_date":"2024","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.71","number":"No.1.2","starting_page":"29","ending_page":"39","languages":["eng"],"identifiers":{"doi":["10.2152/jmi.71.29"],"issn":["1349-6867"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
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