type: misc

label: url

en: 微小重力環境を利用した筋萎縮機構の研究

ja: 微小重力環境を利用した筋萎縮機構の研究

en: 実験医学増刊号

ja: 実験医学増刊号


en: Mitochondria-mediated mechanosensing mechanism in skeletal muscle

ja: 筋ミトコンドリアによる重力感知

en: Science of the Living Body

ja: 生体の科学


en: 微小重力環境における筋萎縮発生メカニズムへの新展開

ja: 微小重力環境における筋萎縮発生メカニズムへの新展開

en: 月刊細胞

ja: 月刊細胞


en: サルコペニアとメカニカルストレス

ja: サルコペニアとメカニカルストレス

en: 診断と治療

ja: 診断と治療


en: [Impacts of physical exercise on remodeling and hypertrophy of skeletal muscle.]

en: The skeletal muscle has high sensitivity for the mechanical stress. Because it is enlarged by training, whereas it is easily withered by lack of exercise. When we exercise, skeletal muscle cells per se sense mechanical loading, and muscular remodeling and the muscular hypertrophy occur. It has been revealed that the intracellular signaling through PGC-1 participates in the remodeling of the skeletal muscle, while PGC-14, an isoform of PGC-1, and the dystrophin-glycoprotein complex play important roles in muscular hypertrophy. This review describes the impact of physical exercise gives on the remodeling and hypertrophy of muscle through the signaling.

en: Clinical Calcium

ja: Clinical Calcium


en: [Plasticity of skeletal muscle against unloading stress.]

en: Recently, muscle atrophy caused by unloading, such as spaceflight and bed rest has been becoming a social problem in Japan. However, the effective countermeasures against these disuse atrophy have not been developed. We have reviewed the mechanisms of disuse atrophy and its possible countermeasures.