{"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37941628","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403682","label":"url"}],"paper_title":{"en":"Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion","ja":"Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion"},"authors":{"en":[{"name":"Sogabe Shu"},{"name":"Tatsuya HABOSHI"},{"name":"Yamaguchi Izumi"},{"name":"Korai Masaaki"},{"name":"Yamamoto Nobuaki"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"曽我部 周"},{"name":"羽星 辰哉"},{"name":"山口 泉"},{"name":"高麗 雅章"},{"name":"山本 伸昭"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion.","ja":"We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion."},"publication_date":"2023-10-13","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.14","number":"No.365","starting_page":"365","ending_page":"365","languages":["eng"],"referee":true,"identifiers":{"doi":["10.25259/SNI_608_2023"],"issn":["2229-5097"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37680937","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403701","label":"url"}],"paper_title":{"en":"Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases.","ja":"Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases."},"authors":{"en":[{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Matsuda Tomohiro"},{"name":"Kuroda Kazutaka"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Izumi Yuishin"}],"ja":[{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"Matsuda Tomohiro"},{"name":"黒田 一駿"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"和泉 唯信"}]},"description":{"en":"In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered.","ja":"In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered."},"publication_date":"2023-08-04","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.14","starting_page":"274","ending_page":"274","languages":["eng"],"referee":true,"identifiers":{"doi":["10.25259/SNI_513_2023"],"issn":["2229-5097"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118394","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37420081","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=398441","label":"url"}],"paper_title":{"en":"Cranial geometry in patients with dystonia and Parkinson's disease.","ja":"Cranial geometry in patients with dystonia and Parkinson's disease."},"authors":{"en":[{"name":"Fujikawa Joji"},{"name":"Morigaki Ryoma"},{"name":"Miyake Kazuhisa"},{"name":"Matsuda Taku"},{"name":"Koyama Hiroshi"},{"name":"Oda Teruo"},{"name":"Yamamoto Nobuaki"},{"name":"Izumi Yuishin"},{"name":"Mure Hideo"},{"name":"Goto Satoshi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"藤川 丈自"},{"name":"森垣 龍馬"},{"name":"三宅 一央"},{"name":"Matsuda Taku"},{"name":"小山 広士"},{"name":"小田 輝王"},{"name":"山本 伸昭"},{"name":"和泉 唯信"},{"name":"牟礼 英生"},{"name":"後藤 惠"},{"name":"髙木 康志"}]},"description":{"en":"Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms.","ja":"Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms."},"publication_date":"2023-07-07","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.13","number":"No.1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-023-37833-3"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118794","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35945008","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390576900004177024/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397648","label":"url"}],"paper_title":{"en":"Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot","ja":"Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot"},"authors":{"en":[{"name":"Yamamoto Nobuaki"},{"name":"Kuroda Kazutaka"},{"name":"Yamamoto Yuki"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Shimada Kenji"},{"name":"Morigaki Ryoma"},{"name":"Kanematsu Yasuhisa"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山本 伸昭"},{"name":"黒田 一駿"},{"name":"山本 雄貴"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"島田 健司"},{"name":"森垣 龍馬"},{"name":"兼松 康久"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion.","ja":"Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion."},"publication_date":"2023-03-15","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.62","number":"No.6","starting_page":"909","ending_page":"913","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.0089-22"],"issn":["0918-2918"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=402350","label":"url"}],"paper_title":{"en":"Evaluation of Biological Metabolic Activity within an Atherosclerotic Plaque using Chemical Exchange Saturation Transfer Imaging","ja":"Evaluation of Biological Metabolic Activity within an Atherosclerotic Plaque using Chemical Exchange Saturation Transfer Imaging"},"authors":{"en":[{"name":"Kanazawa Yuki"},{"name":"Miyati Tosiaki"},{"name":"Harada Masafumi"},{"name":"Miyoshi Mitsuharu"},{"name":"Matsumoto Yuki"},{"name":"Hayashi Hiroaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"金澤 裕樹"},{"name":"Miyati Tosiaki"},{"name":"原田 雅史"},{"name":"Miyoshi Mitsuharu"},{"name":"松元 友暉"},{"name":"Hayashi Hiroaki"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"publication_date":"2023","publication_name":{"en":"Proceedings of ISMRM","ja":"Proceedings of ISMRM"},"volume":"Vol.32","number":"No.2982","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=402346","label":"url"}],"paper_title":{"en":"Diffusion weighted-viscosity imaging for atherosclerotic plaques","ja":"Diffusion weighted-viscosity imaging for atherosclerotic plaques"},"authors":{"en":[{"name":"Seguchi Mayuka"},{"name":"Kanazawa Yuki"},{"name":"Miyati Tosiaki"},{"name":"Harada Masafumi"},{"name":"Miyoshi Mitsuharu"},{"name":"Matsumoto Yuki"},{"name":"Hayashi Hiroaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"瀬口 真友香"},{"name":"金澤 裕樹"},{"name":"Miyati Tosiaki"},{"name":"原田 雅史"},{"name":"Miyoshi Mitsuharu"},{"name":"松元 友暉"},{"name":"Hayashi Hiroaki"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"publication_date":"2023","publication_name":{"en":"Proceedings of ISMRM","ja":"Proceedings of ISMRM"},"volume":"Vol.32","number":"No.1519","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"http://repo.lib.tokushima-u.ac.jp/117958","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050295181679880704/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=402623","label":"url"}],"paper_title":{"en":"循環器病を防ぐために 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み","ja":"循環器病を防ぐために 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み"},"authors":{"en":[{"name":"Kanematsu Yasuhisa"},{"name":"Yamaguchi Izumi"},{"name":"Ishihara Manabu"},{"name":"Sogabe Shu"},{"name":"Miyamoto Takeshi"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Kazutaka KURODA"},{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"兼松 康久"},{"name":"山口 泉"},{"name":"石原 学"},{"name":"曽我部 周"},{"name":"宮本 健志"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"黒田 一駿"},{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city.","ja":"Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city."},"publication_date":"2022-12-25","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.78","number":"No.5-6","starting_page":"135","ending_page":"138","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118878","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36545833","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85145451559&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393891","label":"url"}],"paper_title":{"en":"Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage","ja":"Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage"},"authors":{"en":[{"name":"Kurashiki Yoshitaka"},{"name":"Kagusa Hiroshi"},{"name":"Yagi Kenji"},{"name":"Kinouchi Tomoya"},{"name":"Sumiyoshi Manabu"},{"name":"Miyamoto Takeshi"},{"name":"Shimada Kenji"},{"name":"Kitazato T Keiko"},{"name":"Uto Yoshihiro"},{"name":"Takagi Yasushi"}],"ja":[{"name":"倉敷 佳孝"},{"name":"鹿草 宏"},{"name":"八木 謙次"},{"name":"木内 智也"},{"name":"住吉 学"},{"name":"宮本 健志"},{"name":"島田 健司"},{"name":"北里 慶子"},{"name":"宇都 義浩"},{"name":"髙木 康志"}]},"description":{"en":"Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0-6) or subacute (day 7-13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163 M2-type- and pro-inflammatory CD16 M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163 M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36 phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy.","ja":"Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0-6) or subacute (day 7-13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163 M2-type- and pro-inflammatory CD16 M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163 M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36 phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy."},"publication_date":"2022-12-22","publication_name":{"en":"Journal of Cerebral Blood Flow and Metabolism","ja":"Journal of Cerebral Blood Flow and Metabolism"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1177/0271678X221147090"],"issn":["1559-7016"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397084","label":"url"}],"paper_title":{"en":"脳静脈洞血栓症に対して経皮的血栓回収術を行った3例","ja":"脳静脈洞血栓症に対して経皮的血栓回収術を行った3例"},"authors":{"en":[{"name":"Kazutaka KURODA"},{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Izumi Yuishin"},{"name":"Yamaguchi Izumi"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Miyamoto Takeshi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"黒田 一駿"},{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"和泉 唯信"},{"name":"山口 泉"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"宮本 健志"},{"name":"髙木 康志"}]},"publication_date":"2022-12","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.78","number":"No.5-6","starting_page":"221","ending_page":"226","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397082","label":"url"}],"paper_title":{"en":"徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,","ja":"徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,"},"authors":{"en":[{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Kazutaka KURODA"},{"name":"Izumi Yuishin"},{"name":"Kanematsu Yasuhisa"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"黒田 一駿"},{"name":"和泉 唯信"},{"name":"兼松 康久"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"髙木 康志"}]},"publication_date":"2022-12","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.78","number":"No.5,6","starting_page":"248","ending_page":"249","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36437372","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393052","label":"url"}],"paper_title":{"en":"Obsessivecompulsive symptoms are negatively correlated with motor severity in patients with generalized dystonia","ja":"Obsessivecompulsive symptoms are negatively correlated with motor severity in patients with generalized dystonia"},"authors":{"en":[{"name":"Matsuda Taku"},{"name":"Morigaki Ryoma"},{"name":"Matsumoto Yuki"},{"name":"Mure Hideo"},{"name":"Miyake Kazuhisa"},{"name":"Nakataki Masahito"},{"name":"Harada Masafumi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"松田 拓"},{"name":"森垣 龍馬"},{"name":"松元 友暉"},{"name":"牟礼 英生"},{"name":"三宅 一央"},{"name":"中瀧 理仁"},{"name":"原田 雅史"},{"name":"髙木 康志"}]},"description":{"en":"We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). \"Checking\" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ϱ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ϱ = 0.72, p = 0.023; left: ϱ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia.","ja":"We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). \"Checking\" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ϱ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ϱ = 0.72, p = 0.023; left: ϱ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia."},"publication_date":"2022-11-27","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.12","number":"No.1","starting_page":"20350","ending_page":"20350","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-022-24826-x"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118079","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36332776","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393053","label":"url"}],"paper_title":{"en":"Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery","ja":"Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery"},"authors":{"en":[{"name":"Shimada Kenji"},{"name":"Miyake Kazuhisa"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Korai Masaaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"島田 健司"},{"name":"三宅 一央"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"高麗 雅章"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery.","ja":"An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery."},"publication_date":"2022-11-02","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.169","starting_page":"e260","ending_page":"e269","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2022.10.121"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117905","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=388617","label":"url"}],"paper_title":{"en":"Transarterial embolization for convexity dural arteriovenous fistula with or without pial arterial supply: A report of four patients","ja":"Transarterial embolization for convexity dural arteriovenous fistula with or without pial arterial supply: A report of four patients"},"authors":{"en":[{"name":"Korai Masaaki"},{"name":"Enomoto Noriya"},{"name":"Satoh Koichi"},{"name":"Matsubara Shunji"},{"name":"Kanematsu Yasuhisa"},{"name":"Yamaguchi Tadashi"},{"name":"Hanaoka Mami"},{"name":"Niki Hitoshi"},{"name":"Matsuzaki Kazuhito"},{"name":"Bando Koji"},{"name":"Hagino Hirotaka"},{"name":"Takagi Yasushi"}],"ja":[{"name":"高麗 雅章"},{"name":"榎本 紀哉"},{"name":"佐藤 浩一"},{"name":"松原 俊二"},{"name":"兼松 康久"},{"name":"山口 真司"},{"name":"花岡 真美"},{"name":"Niki Hitoshi"},{"name":"松﨑 和仁"},{"name":"板東 康司"},{"name":"萩野 寛隆"},{"name":"髙木 康志"}]},"publication_date":"2022-08-05","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.13","number":"No.340","starting_page":"1","ending_page":"6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.25259/SNI_215_2022"],"issn":["2152-7806"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118913","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36676025","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396461","label":"url"}],"paper_title":{"en":"Diagnosis and Treatment of Tremor in Parkinson's Disease Using Mechanical Devices","ja":"Diagnosis and Treatment of Tremor in Parkinson's Disease Using Mechanical Devices"},"authors":{"en":[{"name":"Fujikawa J"},{"name":"Morigaki Ryoma"},{"name":"Yamamoto Nobuaki"},{"name":"Nakanishi H"},{"name":"Oda T"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Fujikawa J"},{"name":"森垣 龍馬"},{"name":"山本 伸昭"},{"name":"Nakanishi H"},{"name":"Oda T"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Parkinsonian tremors are sometimes confused with essential tremors or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices are also commonly used to treat tremors and have been actively researched and developed. Here, we aimed to review recent progress and the efficacy of the devices related to Parkinsonian tremors. The PubMed and Scopus databases were searched for articles. We searched for \"Parkinson disease\" and \"tremor\" and \"device\". Eighty-six articles were selected by our systematic approach. Many studies demonstrated that the diagnosis and evaluation of tremors in patients with PD can be done accurately by machine learning algorithms. Mechanical devices for tremor suppression include deep brain stimulation (DBS), electrical muscle stimulation, and orthosis. In recent years, adaptive DBS and optimization of stimulation parameters have been studied to further improve treatment efficacy. Due to developments using state-of-the-art techniques, effectiveness in diagnosing and evaluating tremor and suppressing it using these devices is satisfactorily high in many studies. However, other than DBS, no devices are in practical use. To acquire high-level evidence, large-scale studies and randomized controlled trials are needed for these devices.","ja":"Parkinsonian tremors are sometimes confused with essential tremors or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices are also commonly used to treat tremors and have been actively researched and developed. Here, we aimed to review recent progress and the efficacy of the devices related to Parkinsonian tremors. The PubMed and Scopus databases were searched for articles. We searched for \"Parkinson disease\" and \"tremor\" and \"device\". Eighty-six articles were selected by our systematic approach. Many studies demonstrated that the diagnosis and evaluation of tremors in patients with PD can be done accurately by machine learning algorithms. Mechanical devices for tremor suppression include deep brain stimulation (DBS), electrical muscle stimulation, and orthosis. In recent years, adaptive DBS and optimization of stimulation parameters have been studied to further improve treatment efficacy. Due to developments using state-of-the-art techniques, effectiveness in diagnosing and evaluating tremor and suppressing it using these devices is satisfactorily high in many studies. However, other than DBS, no devices are in practical use. To acquire high-level evidence, large-scale studies and randomized controlled trials are needed for these devices."},"publication_date":"2022-07","publication_name":{"en":"Life","ja":"Life"},"volume":"Vol.13","number":"No.1","starting_page":"78","ending_page":"78","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/life13010078"],"issn":["2075-1729"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117703","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35725479","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393313","label":"url"}],"paper_title":{"en":"An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with infammatory changes in rat brain harboring cerebral aneurysms prone to rupture","ja":"An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with infammatory changes in rat brain harboring cerebral aneurysms prone to rupture"},"authors":{"en":[{"name":"Shikata Eiji"},{"name":"Miyamoto Takeshi"},{"name":"Yamaguchi Tadashi"},{"name":"Yamaguchi Izumi"},{"name":"Kagusa Hiroshi"},{"name":"Gotoh Daiki"},{"name":"Shimada Kenji"},{"name":"Tada Yoshiteru"},{"name":"Yagi Kenji"},{"name":"北里 慶子"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"四方 英二"},{"name":"宮本 健志"},{"name":"山口 真司"},{"name":"山口 泉"},{"name":"鹿草 宏"},{"name":"後藤 大貴"},{"name":"島田 健司"},{"name":"多田 恵曜"},{"name":"八木 謙次"},{"name":"北里 慶子"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be clarified, particularly the pathophysiology of brain harboring intracranial aneurysms (IAs). To elucidate the pathology in brain harboring IAs, we examined the significance of the receptor for advanced glycation end-products (RAGE)/mineralocorticoid receptor (MR) pathway and Na/K-ATPase (ATP1α3). Ten-week-old female rats were subjected to oophorectomy as well as hypertension and hemodynamic changes to induce IAs, and were fed a high-salt diet. Brain damage in these rats was assessed by inflammatory changes in comparison to sham-operated rats fed a standard diet. Six weeks after IA induction (n = 30), irregular morphological changes, i.e., an enlarged vessel diameter and vascular wall, were observed in all of the left posterior cerebral arteries (Lt PCAs) prone to rupture. Approximately 20% of rats had ruptured IAs within 6 weeks. In brain harboring unruptured IAs at the PCA, the mRNA levels of RAGE and MR were higher, and that of ATP1α3 was lower than those in the sham-operated rats (p < 0.05, each). Immunohistochemically, elevated expression of RAGE and MR, and decreased expression of ATP1α3 were observed in the brain parenchyma adjacent to the Lt PCA, resulting in increased Iba-1 and S100B expression that reflected the inflammatory changes. There was no difference between the unruptured and ruptured aneurysm rat groups. Treatment with the MR antagonist esaxerenone abrogated these changes, and led to cerebral and vascular normalization and prolonged subarachnoid hemorrhage-free survival (p < 0.05). Regulation of the imbalance between the RAGE/MR pathway and ATP1α3 may help attenuate the damage in brain harboring IAs, and further studies are warranted to clarify the significance of the down-regulation of the MR/RAGE pathway and the up-regulation of ATP1α3 for attenuating the pathological changes in brain harboring IAs.","ja":"An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be clarified, particularly the pathophysiology of brain harboring intracranial aneurysms (IAs). To elucidate the pathology in brain harboring IAs, we examined the significance of the receptor for advanced glycation end-products (RAGE)/mineralocorticoid receptor (MR) pathway and Na/K-ATPase (ATP1α3). Ten-week-old female rats were subjected to oophorectomy as well as hypertension and hemodynamic changes to induce IAs, and were fed a high-salt diet. Brain damage in these rats was assessed by inflammatory changes in comparison to sham-operated rats fed a standard diet. Six weeks after IA induction (n = 30), irregular morphological changes, i.e., an enlarged vessel diameter and vascular wall, were observed in all of the left posterior cerebral arteries (Lt PCAs) prone to rupture. Approximately 20% of rats had ruptured IAs within 6 weeks. In brain harboring unruptured IAs at the PCA, the mRNA levels of RAGE and MR were higher, and that of ATP1α3 was lower than those in the sham-operated rats (p < 0.05, each). Immunohistochemically, elevated expression of RAGE and MR, and decreased expression of ATP1α3 were observed in the brain parenchyma adjacent to the Lt PCA, resulting in increased Iba-1 and S100B expression that reflected the inflammatory changes. There was no difference between the unruptured and ruptured aneurysm rat groups. Treatment with the MR antagonist esaxerenone abrogated these changes, and led to cerebral and vascular normalization and prolonged subarachnoid hemorrhage-free survival (p < 0.05). Regulation of the imbalance between the RAGE/MR pathway and ATP1α3 may help attenuate the damage in brain harboring IAs, and further studies are warranted to clarify the significance of the down-regulation of the MR/RAGE pathway and the up-regulation of ATP1α3 for attenuating the pathological changes in brain harboring IAs."},"publication_date":"2022-06-20","publication_name":{"en":"Journal of Neuroinflammation","ja":"Journal of Neuroinflammation"},"volume":"Vol.19","number":"No.161","starting_page":"161","ending_page":"161","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/s12974-022-02526-7"],"issn":["1742-2094"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35733826","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385755","label":"url"}],"paper_title":{"en":"Efficacy of intraarterial indocyanine green videoangiography in surgery for arteriovenous fistula at the craniocervical junction in a hybrid operating room: illustrative cases","ja":"Efficacy of intraarterial indocyanine green videoangiography in surgery for arteriovenous fistula at the craniocervical junction in a hybrid operating room: illustrative cases"},"authors":{"en":[{"name":"Shimada Kenji"},{"name":"Yamaguchi Izumi"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Miyake Kazuhisa"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"島田 健司"},{"name":"山口 泉"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"三宅 一央"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Case 1 involved a 71-year-old man presenting with tetraparesis after sudden onset of severe headache due to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) demonstrated CCJ epidural AVF. Intraarterial ICG videoangiography revealed the drainer, which had been difficult to identify. The AVF disappeared after disconnection of the drainer. Case 2 involved a 68-year-old man presenting with severe headache due to SAH. DSA showed multiple AVFs at the CCJ and cerebellar tentorium. Intraarterial ICG videoangiography demonstrated concomitant perimedullary AVF and dural AVF at the CCJ. All AVFs disappeared postoperatively. Intraarterial ICG videoangiography was useful for definitive diagnosis of CCJ AVF, facilitating identification of feeders and drainers with bright and high phase contrast and allowing repeated testing to confirm flow direction.","ja":"Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Case 1 involved a 71-year-old man presenting with tetraparesis after sudden onset of severe headache due to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) demonstrated CCJ epidural AVF. Intraarterial ICG videoangiography revealed the drainer, which had been difficult to identify. The AVF disappeared after disconnection of the drainer. Case 2 involved a 68-year-old man presenting with severe headache due to SAH. DSA showed multiple AVFs at the CCJ and cerebellar tentorium. Intraarterial ICG videoangiography demonstrated concomitant perimedullary AVF and dural AVF at the CCJ. All AVFs disappeared postoperatively. Intraarterial ICG videoangiography was useful for definitive diagnosis of CCJ AVF, facilitating identification of feeders and drainers with bright and high phase contrast and allowing repeated testing to confirm flow direction."},"publication_date":"2022-06-06","publication_name":{"en":"Journal of Neurosurgery. Case Lessons","ja":"Journal of Neurosurgery. Case Lessons"},"volume":"Vol.3","number":"No.23","starting_page":"1","ending_page":"6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3171/CASE22100"],"issn":["2694-1902"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35734231","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85160834258&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385756","label":"url"}],"paper_title":{"en":"Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case","ja":"Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case"},"authors":{"en":[{"name":"Yamaguchi Izumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Yamamoto Nobuaki"},{"name":"Miyake Kazuhisa"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Shikata Eiji"},{"name":"Ishihara Manabu"},{"name":"山本 陽子"},{"name":"Kuroda Kazutaka"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 泉"},{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"山本 伸昭"},{"name":"三宅 一央"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"四方 英二"},{"name":"石原 学"},{"name":"山本 陽子"},{"name":"黒田 一駿"},{"name":"髙木 康志"}]},"description":{"en":"Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms.","ja":"Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms."},"publication_date":"2022-05-23","publication_name":{"en":"Journal of Neurosurgery. Case Lessons","ja":"Journal of Neurosurgery. Case Lessons"},"volume":"Vol.3","number":"No.21","starting_page":"CASE2267","ending_page":"CASE2267","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3171/CASE2267"],"issn":["2694-1902"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117700","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35594890","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385757","label":"url"}],"paper_title":{"en":"Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats","ja":"Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats"},"authors":{"en":[{"name":"Yamaguchi Tadashi"},{"name":"Miyamoto Takeshi"},{"name":"Shikata Eiji"},{"name":"Yamaguchi Izumi"},{"name":"Shimada Kenji"},{"name":"Yagi Kenji"},{"name":"Tada Yoshiteru"},{"name":"Korai Masaaki"},{"name":"Kitazato T. Keiko"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 真司"},{"name":"宮本 健志"},{"name":"四方 英二"},{"name":"山口 泉"},{"name":"島田 健司"},{"name":"八木 謙次"},{"name":"多田 恵曜"},{"name":"高麗 雅章"},{"name":"北里 慶子"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.","ja":"Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model."},"publication_date":"2022-05-20","publication_name":{"en":"Journal of Neurosurgery","ja":"Journal of Neurosurgery"},"starting_page":"1","ending_page":"8","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3171/2022.4.JNS212945"],"issn":["1933-0693"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35486878","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385479","label":"url"}],"paper_title":{"en":"A Novel Approach to Microvascular Decompression for Hemifacial Spasm: Method Description and Associated Outcome","ja":"A Novel Approach to Microvascular Decompression for Hemifacial Spasm: Method Description and Associated Outcome"},"authors":{"en":[{"name":"Nagahiro Shinji"},{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Takagi Yasushi"}],"ja":[{"name":"永廣 信治"},{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"髙木 康志"}]},"description":{"en":"Microvascular decompression (MVD) is the only potential cure for hemifacial spasm (HFS). However, traditional techniques such as the interposition method may have limited effect in some cases. Alternative techniques have been proposed; however, they can be more complex or difficult to perform than the standard approach. To describe a safe decompression technique-the \"shelter method\"-which involves creating a shelter-like space around the facial nerve root exit zone and present associated outcomes. Medical records and intraoperative findings of 92 patients with HFS who underwent MVD using the shelter method between April 1997 and March 2017 were retrospectively reviewed. As a historical control group, we included 53 patients who had undergone MVD by the traditional interposition method before March 1989. The patients were divided into 3 subgroups according to the arteries involved and degree or direction of arterial compression to the seventh nerve. Patient outcomes were assessed as excellent, good, fair, and poor according to the MVD scoring system of the Japan Society for MVD Surgery. In the shelter method group, complete disappearance of HFS was achieved in 87 patients (94.6%). The curative rate of the shelter method group was significantly higher than that of the interposition method group. The overall complication rates were significantly lower in the shelter method group than in the interposition method group. Our findings indicate high curative and low complication rates of the shelter method, suggesting that it helps treat HFS caused by various types of arterial compression.","ja":"Microvascular decompression (MVD) is the only potential cure for hemifacial spasm (HFS). However, traditional techniques such as the interposition method may have limited effect in some cases. Alternative techniques have been proposed; however, they can be more complex or difficult to perform than the standard approach. To describe a safe decompression technique-the \"shelter method\"-which involves creating a shelter-like space around the facial nerve root exit zone and present associated outcomes. Medical records and intraoperative findings of 92 patients with HFS who underwent MVD using the shelter method between April 1997 and March 2017 were retrospectively reviewed. As a historical control group, we included 53 patients who had undergone MVD by the traditional interposition method before March 1989. The patients were divided into 3 subgroups according to the arteries involved and degree or direction of arterial compression to the seventh nerve. Patient outcomes were assessed as excellent, good, fair, and poor according to the MVD scoring system of the Japan Society for MVD Surgery. In the shelter method group, complete disappearance of HFS was achieved in 87 patients (94.6%). The curative rate of the shelter method group was significantly higher than that of the interposition method group. The overall complication rates were significantly lower in the shelter method group than in the interposition method group. Our findings indicate high curative and low complication rates of the shelter method, suggesting that it helps treat HFS caused by various types of arterial compression."},"publication_date":"2022-04-29","publication_name":{"en":"Operative Neurosurgery","ja":"Operative Neurosurgery"},"volume":"Vol.00","starting_page":"1","ending_page":"7","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1227/ons.0000000000000223"],"issn":["2332-4260"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85175417356&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=404217","label":"url"}],"paper_title":{"en":"Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?","ja":"Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?"},"authors":{"en":[{"name":"Shikata Eiji"},{"name":"Yamaguchi Izumi"},{"name":"Korai Masaaki"},{"name":"Miyamoto Takeshi"},{"name":"Yamaguchi Tadashi"},{"name":"Kagusa Hiroshi"},{"name":"Shimada Kenji"},{"name":"Tada Yoshiteru"},{"name":"Kitazato Keiko"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"四方 英二"},{"name":"山口 泉"},{"name":"高麗 雅章"},{"name":"宮本 健志"},{"name":"山口 真司"},{"name":"鹿草 宏"},{"name":"島田 健司"},{"name":"多田 恵曜"},{"name":"北里 慶子"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"publication_date":"2022-04-01","publication_name":{"en":"Brain Hemorrhages","ja":"Brain Hemorrhages"},"volume":"Vol.137","number":"No.6","starting_page":"1707","ending_page":"1717","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.hest.2023.10.005"],"issn":["2589-238X"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117340","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35462692","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=388974","label":"url"}],"paper_title":{"en":"Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.","ja":"Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials."},"authors":{"en":[{"name":"Fujikawa Joji"},{"name":"Morigaki Ryoma"},{"name":"Yamamoto Nobuaki"},{"name":"Oda Teruo"},{"name":"Nakanishi Hiroshi"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"藤川 丈自"},{"name":"森垣 龍馬"},{"name":"山本 伸昭"},{"name":"小田 輝王"},{"name":"中西 浩史"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these.","ja":"Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these."},"publication_date":"2022-03-29","publication_name":{"en":"Frontiers in Aging Neuroscience","ja":"Frontiers in Aging Neuroscience"},"volume":"Vol.14","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3389/fnagi.2022.807909"],"issn":["1663-4365"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35279594","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85126008460&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384868","label":"url"}],"paper_title":{"en":"Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging","ja":"Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging"},"authors":{"en":[{"name":"Tada Yoshiteru"},{"name":"Fujihara Toshitaka"},{"name":"Shimada Kenji"},{"name":"Yamamoto Nobuaki"},{"name":"Yamazaki Hiroki"},{"name":"Izumi Yuishin"},{"name":"Harada Masafumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"多田 恵曜"},{"name":"藤原 敏孝"},{"name":"島田 健司"},{"name":"山本 伸昭"},{"name":"山﨑 博輝"},{"name":"和泉 唯信"},{"name":"原田 雅史"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures. Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. ASL-positive), and DWI abnormalities (DWI-negative vs. DWI-positive). The diagnosis was made based on seizure semiology, electroencephalography, and conventional imaging modalities. ASL and DWI abnormalities were based on visual assessment. Of the 41 patients, eight (19.5%) displayed normal ASL findings. The proportion of patients with focal aware seizures (FAS) was significantly higher among ASL-negative patients (62.5%) than that in ASL-positive patients (15.2%); the proportion of patients with focal impaired awareness seizures (FIAS) was significantly lower among ASL-negative patients (12.5%) than that among ASL-positive patients (57.6%). Hyperintensity findings on DWI were observed in 12 patients (29.3%, DWI-positive). The proportion of patients with FIAS was significantly higher among DWI-positive patients (75.0%) than that among DWI-negative patients (37.9%). Multivariate analysis revealed that FAS and FIAS were associated with normal ASL findings (odds ratio [OR]: 21.37, P = 0.010) and DWI abnormalities (OR = 6.11, P = 0.028). A diagnosis of seizures should not be excluded based on normal ASL findings, especially in patients with FAS. FIAS may be a risk factor for neuronal damage caused by seizure activity.","ja":"Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures. Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. ASL-positive), and DWI abnormalities (DWI-negative vs. DWI-positive). The diagnosis was made based on seizure semiology, electroencephalography, and conventional imaging modalities. ASL and DWI abnormalities were based on visual assessment. Of the 41 patients, eight (19.5%) displayed normal ASL findings. The proportion of patients with focal aware seizures (FAS) was significantly higher among ASL-negative patients (62.5%) than that in ASL-positive patients (15.2%); the proportion of patients with focal impaired awareness seizures (FIAS) was significantly lower among ASL-negative patients (12.5%) than that among ASL-positive patients (57.6%). Hyperintensity findings on DWI were observed in 12 patients (29.3%, DWI-positive). The proportion of patients with FIAS was significantly higher among DWI-positive patients (75.0%) than that among DWI-negative patients (37.9%). Multivariate analysis revealed that FAS and FIAS were associated with normal ASL findings (odds ratio [OR]: 21.37, P = 0.010) and DWI abnormalities (OR = 6.11, P = 0.028). A diagnosis of seizures should not be excluded based on normal ASL findings, especially in patients with FAS. FIAS may be a risk factor for neuronal damage caused by seizure activity."},"publication_date":"2022-03-07","publication_name":{"en":"Journal of the Neurological Sciences","ja":"Journal of the Neurological Sciences"},"volume":"Vol.436","starting_page":"1","ending_page":"8","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jns.2022.120223"],"issn":["1878-5883"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117192","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35242438","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384410","label":"url"}],"paper_title":{"en":"The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation","ja":"The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation"},"authors":{"en":[{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Yamaguchi Izumi"},{"name":"Ishihara Manabu"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Shimada Kenji"},{"name":"Takagi Yasushi"},{"name":"Izumi Yuishin"}],"ja":[{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"兼松 康久"},{"name":"山口 泉"},{"name":"石原 学"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"島田 健司"},{"name":"髙木 康志"},{"name":"和泉 唯信"}]},"description":{"en":"Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the \"claw sign,\" was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke.","ja":"Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the \"claw sign,\" was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke."},"publication_date":"2022-02-25","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.13","number":"No.72","starting_page":"1","ending_page":"7","languages":["eng"],"referee":true,"identifiers":{"doi":["10.25259/SNI_1160_2021"],"issn":["2229-5097"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117022","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35466132","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85128801353&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385411","label":"url"}],"paper_title":{"en":"Development of a Navigation-guided Fence-post Catheter for Brain Tumor Resection","ja":"Development of a Navigation-guided Fence-post Catheter for Brain Tumor Resection"},"authors":{"en":[{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Fujihara Toshitaka"},{"name":"Azumi Mai"},{"name":"Takagi Yasushi"}],"ja":[{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"藤原 敏孝"},{"name":"安積 麻衣"},{"name":"髙木 康志"}]},"description":{"en":"Navigation system devices have been developed to allow precise resection of brain tumor. The fence-post catheter techniques that use a navigation system have been used in many neurosurgery centers. However, an exclusive catheter for the fence-post catheter techniques have not been made, and substituted silicon tube of the cerebral ventricle drainage or a Nelaton catheter is widely used. In this brief technical note, we describe a new fence-post catheter with steel tip device that was designed for more precise tissue resection and is useful in tumor resection. The newly designed fence-post catheter helps to visually gauge the accurate depth from the tumor bottom during tumor resection. Furthermore, the catheter tip has moderate weight and is made of a non-magnetic material. Using our fence-post catheter, which has a metal part at the tip of the tube (length, 13 mm), operators can clearly notice that they are getting closer to base of the tumor by checking the metal part during the resection of deep tumors. Our newly developed fence-post tube enables easy confirmation of the distance to deep-tissue regions and improves the degree of safety during tumor removal. J. Med. Invest. 69 : 117-119, February, 2022.","ja":"Navigation system devices have been developed to allow precise resection of brain tumor. The fence-post catheter techniques that use a navigation system have been used in many neurosurgery centers. However, an exclusive catheter for the fence-post catheter techniques have not been made, and substituted silicon tube of the cerebral ventricle drainage or a Nelaton catheter is widely used. In this brief technical note, we describe a new fence-post catheter with steel tip device that was designed for more precise tissue resection and is useful in tumor resection. The newly designed fence-post catheter helps to visually gauge the accurate depth from the tumor bottom during tumor resection. Furthermore, the catheter tip has moderate weight and is made of a non-magnetic material. Using our fence-post catheter, which has a metal part at the tip of the tube (length, 13 mm), operators can clearly notice that they are getting closer to base of the tumor by checking the metal part during the resection of deep tumors. Our newly developed fence-post tube enables easy confirmation of the distance to deep-tissue regions and improves the degree of safety during tumor removal. J. Med. Invest. 69 : 117-119, February, 2022."},"publication_date":"2022-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.69","number":"No.1,2","starting_page":"117","ending_page":"119","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.69.117"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382977","label":"url"}],"paper_title":{"en":"Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study","ja":"Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study"},"authors":{"en":[{"name":"Yamaguchi Izumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Mizobuchi Yoshifumi"},{"name":"Tada Yoshiteru"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Ishihara Manabu"},{"name":"Kagusa Hiroshi"},{"name":"Yamamoto Yoko"},{"name":"Matsuda Taku"},{"name":"Kitazato T. Keiko"},{"name":"Okayama Yoshihiro"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 泉"},{"name":"兼松 康久"},{"name":"溝渕 佳史"},{"name":"多田 恵曜"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"石原 学"},{"name":"鹿草 宏"},{"name":"山本 陽子"},{"name":"松田 拓"},{"name":"北里 慶子"},{"name":"岡山"},{"name":"髙木 康志"}]},"publication_date":"2021-12","publication_name":{"en":"Journal of Clinical Neuroscience","ja":"Journal of Clinical Neuroscience"},"volume":"Vol.94","starting_page":"244","ending_page":"249","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jocn.2021.10.037"],"issn":["0967-5868"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34119401","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382429","label":"url"}],"paper_title":{"en":"Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source","ja":"Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source"},"authors":{"en":[{"name":"Kusunose Kenya"},{"name":"Takahashi Hironori"},{"name":"Nishio Susumu"},{"name":"Hirata Yukina"},{"name":"Zheng Robert"},{"name":"Ise Takayuki"},{"name":"Yamaguchi Koji"},{"name":"Yagi Shusuke"},{"name":"Fukuda Daiju"},{"name":"Yamada Hirotsugu"},{"name":"Soeki Takeshi"},{"name":"Wakatsuki Tetsuzo"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Sata Masataka"}],"ja":[{"name":"楠瀬 賢也"},{"name":"高橋 寛典"},{"name":"西尾 進"},{"name":"平田 有紀奈"},{"name":"Robert Zheng"},{"name":"伊勢 孝之"},{"name":"山口 浩司"},{"name":"八木 秀介"},{"name":"福田 大受"},{"name":"山田 博胤"},{"name":"添木 武"},{"name":"若槻 哲三"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"佐田 政隆"}]},"description":{"en":"In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF.","ja":"In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF."},"publication_date":"2021-11","publication_name":{"en":"Journal of Cardiology","ja":"Journal of Cardiology"},"volume":"Vol.78","number":"No.5","starting_page":"355","ending_page":"361","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jjcc.2021.05.005"],"issn":["1876-4738"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116871","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34478890","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85115331132&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382706","label":"url"}],"paper_title":{"en":"Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations","ja":"Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations"},"authors":{"en":[{"name":"Shimada Kenji"},{"name":"Yamaguchi Izumi"},{"name":"Ishihara Manabu"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Miyake Kazuhisa"},{"name":"Tada Yoshiteru"},{"name":"北里 慶子"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"島田 健司"},{"name":"山口 泉"},{"name":"石原 学"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"三宅 一央"},{"name":"多田 恵曜"},{"name":"北里 慶子"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs.","ja":"Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs."},"publication_date":"2021-08","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"starting_page":"E1","ending_page":"E7","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2021.08.118"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34051365","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385766","label":"url"}],"paper_title":{"en":"Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors","ja":"Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors"},"authors":{"en":[{"name":"Korai Masaaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Yamaguchi Izumi"},{"name":"Yamaguchi Tadashi"},{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Miyamoto Takeshi"},{"name":"Shimada Kenji"},{"name":"Satomi Junichiro"},{"name":"Hanaoka Mami"},{"name":"Matsuzaki Kazuhito"},{"name":"Satoh Koichi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"高麗 雅章"},{"name":"兼松 康久"},{"name":"山口 泉"},{"name":"山口 真司"},{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"宮本 健志"},{"name":"島田 健司"},{"name":"里見 淳一郎"},{"name":"花岡 真実"},{"name":"松﨑 和仁"},{"name":"佐藤 浩一"},{"name":"髙木 康志"}]},"description":{"en":"Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture.","ja":"Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture."},"publication_date":"2021-08","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.152","starting_page":"e86","ending_page":"e93","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2021.05.018"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116560","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378122","label":"url"}],"paper_title":{"en":"Dystonia and cerebellum: From bench to bedside","ja":"Dystonia and cerebellum: From bench to bedside"},"authors":{"en":[{"name":"Morigaki Ryoma"},{"name":"Miyamoto Ryosuke"},{"name":"Matsuda Taku"},{"name":"Miyake Kazuhisa"},{"name":"Yamamoto Nobuaki"},{"name":"Takagi Yasushi"}],"ja":[{"name":"森垣 龍馬"},{"name":"宮本 亮介"},{"name":"松田 拓"},{"name":"三宅 一央"},{"name":"山本 伸昭"},{"name":"髙木 康志"}]},"publication_date":"2021-08","publication_name":{"en":"Life","ja":"Life"},"volume":"Vol.11","number":"No.8","starting_page":"776","ending_page":"776","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/life11080776"],"issn":["2075-1729"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116448","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34301977","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391518","label":"url"}],"paper_title":{"en":"Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.","ja":"Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway."},"authors":{"en":[{"name":"Shono Kenji"},{"name":"Mizobuchi Yoshifumi"},{"name":"Yamaguchi Izumi"},{"name":"Nakajima Kohhei"},{"name":"Fujiwara Yuri"},{"name":"Fujihara Toshitaka"},{"name":"Kitazato Keiko"},{"name":"Matsuzaki Kazuhito"},{"name":"Uto Yoshihiro"},{"name":"Sampetrean Oltea"},{"name":"Saya Hideyuki"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Shono Kenji"},{"name":"溝渕 佳史"},{"name":"山口 泉"},{"name":"中島 公平"},{"name":"Fujiwara Yuri"},{"name":"藤原 敏孝"},{"name":"Kitazato Keiko"},{"name":"松﨑 和仁"},{"name":"宇都 義浩"},{"name":"Sampetrean Oltea"},{"name":"Saya Hideyuki"},{"name":"髙木 康志"}]},"description":{"en":"Glioblastoma (GBM) has high mortality rates because of extreme therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) combined with low-intensity ultrasonication (US) and PpIX, as a sonosensitizer, is an emerging and promising approach, although its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented the anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, an MDR1 inhibitor, and augmented anti-tumor effects of SDT. MDR1 down-regulation via the Akt/NF-κB pathway by celecoxib was confirmed, using an NF-κB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via the Akt/NF-κB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM.","ja":"Glioblastoma (GBM) has high mortality rates because of extreme therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) combined with low-intensity ultrasonication (US) and PpIX, as a sonosensitizer, is an emerging and promising approach, although its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented the anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, an MDR1 inhibitor, and augmented anti-tumor effects of SDT. MDR1 down-regulation via the Akt/NF-κB pathway by celecoxib was confirmed, using an NF-κB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via the Akt/NF-κB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM."},"publication_date":"2021-07-23","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.11","number":"No.1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-021-93896-0"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34345487","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395905","label":"url"}],"paper_title":{"en":"Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report.","ja":"Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report."},"authors":{"en":[{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Tada Yoshiteru"},{"name":"Korai Masaaki"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Yamaguchi Izumi"},{"name":"Ymamoto Yoko"},{"name":"Yamamoto Nobuaki"},{"name":"Yamamoto Yuki"},{"name":"Satoh Koichi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"多田 恵曜"},{"name":"高麗 雅章"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"山口 泉"},{"name":"山本 陽子"},{"name":"山本 伸昭"},{"name":"山本 雄貴"},{"name":"佐藤 浩一"},{"name":"髙木 康志"}]},"description":{"en":"The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms.","ja":"The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms."},"publication_date":"2021-07-12","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.12","number":"No.347","languages":["eng"],"referee":true,"identifiers":{"doi":["10.25259/SNI_533_2021"],"issn":["2229-5097"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34226923","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85120384111&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=376699","label":"url"}],"paper_title":{"en":"STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases","ja":"STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases"},"authors":{"en":[{"name":"Phuong Tran Pham"},{"name":"Fukuda Daiju"},{"name":"Nishimoto Sachiko"},{"name":"Kim-Kaneyama JR"},{"name":"Lei XF"},{"name":"Takahashi Yutaka"},{"name":"Sato Tomohito"},{"name":"Tanaka Kimie"},{"name":"Suto Kumiko"},{"name":"Kawabata Yutaka"},{"name":"Yamaguchi Koji"},{"name":"Yagi Shusuke"},{"name":"Kusunose Kenya"},{"name":"Yamada Hirotsugu"},{"name":"Soeki Takeshi"},{"name":"Wakatsuki Tetsuzo"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Shimabukuro Michio"},{"name":"Setou Mitsutoshi"},{"name":"Barber N Glen"},{"name":"Sata Masataka"}],"ja":[{"name":"Pham Tran Phuong"},{"name":"福田 大受"},{"name":"西本 幸子"},{"name":"Kim-Kaneyama JR"},{"name":"Lei XF"},{"name":"Takahashi Yutaka"},{"name":"Sato Tomohito"},{"name":"Tanaka Kimie"},{"name":"數藤 久美子"},{"name":"川端 豊"},{"name":"山口 浩司"},{"name":"八木 秀介"},{"name":"楠瀬 賢也"},{"name":"山田 博胤"},{"name":"添木 武"},{"name":"若槻 哲三"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"島袋 充生"},{"name":"Setou Mitsutoshi"},{"name":"Barber N Glen"},{"name":"佐田 政隆"}]},"description":{"en":"Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.","ja":"Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis."},"publication_date":"2021-07-06","publication_name":{"en":"European Heart Journal","ja":"European Heart Journal"},"volume":"Vol.42","number":"No.42","starting_page":"4336","ending_page":"4348","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1093/eurheartj/ehab249"],"issn":["1522-9645"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35079478","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391516","label":"url"}],"paper_title":{"en":"Efficacy of Intra-arterial Indocyanine Green Videoangiography in Hemangioblastoma Surgery: A Case Report.","ja":"Efficacy of Intra-arterial Indocyanine Green Videoangiography in Hemangioblastoma Surgery: A Case Report."},"authors":{"en":[{"name":"Shimada Kenji"},{"name":"Yamamoto Yoko"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Fujihara Toshitaka"},{"name":"Nakajima Kohhei"},{"name":"Mizobuchi Yoshifumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"島田 健司"},{"name":"Yamamoto Yoko"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"藤原 敏孝"},{"name":"中島 公平"},{"name":"溝渕 佳史"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"Intravenous indocyanine green (ICG) videoangiography is reportedly useful for vascular neurosurgery, and for treating hemangioblastoma due to its high vascularity. Videoangiography obtained after intra-arterial ICG injection has emerged as a more useful option than that after intravenous injection. This report offers the first description of a case of hemangioblastoma successfully treated using intra-arterial ICG videoangiography, and describes the efficacy of this technique. A 20-year-old man presented with progressive cerebellar ataxia and dysphagia. Magnetic resonance imaging (MRI) revealed an enhanced solid tumor in the medulla oblongata. Digital subtraction angiography (DSA) showed a highly vascularized tumor. Surgery was performed to remove the tumor in a hybrid operating room. A catheter was introduced into the vertebral artery (VA) for intra-arterial ICG videoangiography. Superficial feeders and drainers were identified and flow dynamic changes in the tumor were assessed by intra-arterial ICG videoangiography. The tumor was removed after confirming lack of flow in the drainer. Intra-arterial ICG videoangiography was more useful than intravenous ICG videoangiography in hemangioblastoma surgery for identifying feeders and drainers and assessing flow dynamics in the tumor. Use of Flow 800 made these findings simpler and easier to evaluate.","ja":"Intravenous indocyanine green (ICG) videoangiography is reportedly useful for vascular neurosurgery, and for treating hemangioblastoma due to its high vascularity. Videoangiography obtained after intra-arterial ICG injection has emerged as a more useful option than that after intravenous injection. This report offers the first description of a case of hemangioblastoma successfully treated using intra-arterial ICG videoangiography, and describes the efficacy of this technique. A 20-year-old man presented with progressive cerebellar ataxia and dysphagia. Magnetic resonance imaging (MRI) revealed an enhanced solid tumor in the medulla oblongata. Digital subtraction angiography (DSA) showed a highly vascularized tumor. Surgery was performed to remove the tumor in a hybrid operating room. A catheter was introduced into the vertebral artery (VA) for intra-arterial ICG videoangiography. Superficial feeders and drainers were identified and flow dynamic changes in the tumor were assessed by intra-arterial ICG videoangiography. The tumor was removed after confirming lack of flow in the drainer. Intra-arterial ICG videoangiography was more useful than intravenous ICG videoangiography in hemangioblastoma surgery for identifying feeders and drainers and assessing flow dynamics in the tumor. Use of Flow 800 made these findings simpler and easier to evaluate."},"publication_date":"2021-07-03","publication_name":{"en":"NMC Case Report Journal","ja":"NMC Case Report Journal"},"volume":"Vol.8","number":"No.1","starting_page":"295","ending_page":"300","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmccrj.cr.2020-0281"],"issn":["2188-4226"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.jstage.jst.go.jp/article/jnet/advpub/0/advpub_cr.2021-0030/_pdf","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390573593425698304/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387395","label":"url"}],"paper_title":{"en":"Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter","ja":"Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter"},"authors":{"en":[{"name":"Yamamoto Nobuaki"},{"name":"Yamamoto Yuki"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Miyamoto Takeshi"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Morigaki Ryoma"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山本 伸昭"},{"name":"山本 雄貴"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"宮本 健志"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"森垣 龍馬"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"
Objective: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.
Case Presentations: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.
Conclusion: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.
","ja":"Objective: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.
Case Presentations: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.
Conclusion: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.
"},"publication_date":"2021-07","publication_name":{"en":"Journal of Neuroendovascular Therapy","ja":"Journal of Neuroendovascular Therapy"},"volume":"Vol.16","number":"No.5","starting_page":"277","ending_page":"282","languages":["eng"],"referee":true,"identifiers":{"doi":["10.5797/jnet.cr.2021-0030"],"issn":["1882-4072"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116561","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34074009","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85107554331&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377488","label":"url"}],"paper_title":{"en":"Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia","ja":"Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia"},"authors":{"en":[{"name":"Koyama Hiroshi"},{"name":"Mure Hideo"},{"name":"Morigaki Ryoma"},{"name":"Miyamoto Ryosuke"},{"name":"Miyake Kazuhisa"},{"name":"Matsuda Taku"},{"name":"Fujita Koji"},{"name":"Izumi Yuishin"},{"name":"Kaji Ryuji"},{"name":"Goto Satoshi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Koyama Hiroshi"},{"name":"牟礼 英生"},{"name":"森垣 龍馬"},{"name":"宮本 亮介"},{"name":"三宅 一央"},{"name":"Matsuda Taku"},{"name":"藤田 浩司"},{"name":"和泉 唯信"},{"name":"梶 龍兒"},{"name":"後藤 惠"},{"name":"髙木 康志"}]},"description":{"en":"Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.","ja":"Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD."},"publication_date":"2021-05-24","publication_name":{"en":"Life","ja":"Life"},"volume":"Vol.11","number":"No.6","starting_page":"477","ending_page":"477","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/life11060477"],"issn":["2075-1729"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116530","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85105944271&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=386034","label":"url"}],"paper_title":{"en":"A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma","ja":"A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma"},"authors":{"en":[{"name":"Muto Kohei"},{"name":"Miyamoto Ryosuke"},{"name":"Terasawa Yuka"},{"name":"Shimatani Yoshimitsu"},{"name":"Hara Keijiro"},{"name":"Kakimoto Takumi"},{"name":"Fukumoto Tatsuya"},{"name":"Osaki Yusuke"},{"name":"Fujita Koji"},{"name":"Harada Masafumi"},{"name":"Uehara Hisanori"},{"name":"Takagi Yasushi"},{"name":"Izumi Yuishin"}],"ja":[{"name":"武藤 浩平"},{"name":"宮本 亮介"},{"name":"寺澤 由佳"},{"name":"島谷 佳光"},{"name":"原 慶次郎"},{"name":"柿本 拓海"},{"name":"福本 竜也"},{"name":"大崎 裕亮"},{"name":"藤田 浩司"},{"name":"原田 雅史"},{"name":"上原 久典"},{"name":"髙木 康志"},{"name":"和泉 唯信"}]},"publication_date":"2021-05","publication_name":{"en":"Human Genome Variation","ja":"Human Genome Variation"},"volume":"Vol.8","number":"No.1","starting_page":"18","ending_page":"18","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41439-021-00150-0"],"issn":["2054-345X"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34012754","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390850247501001984/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=381578","label":"url"}],"paper_title":{"en":"Reversible Hearing Impairment Due to Inferior Colliculi Compression by a Pineal Glial Cyst","ja":"Reversible Hearing Impairment Due to Inferior Colliculi Compression by a Pineal Glial Cyst"},"authors":{"en":[{"name":"Mizobuchi Yoshifumi"},{"name":"Shimada Aki"},{"name":"Nakajima Kohhei"},{"name":"Kagusa Hiroshi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"溝渕 佳史"},{"name":"島田 亜紀"},{"name":"中島 公平"},{"name":"鹿草 宏"},{"name":"髙木 康志"}]},"publication_date":"2021-03","publication_name":{"en":"NMC Case Report Journal","ja":"NMC Case Report Journal"},"volume":"Vol.8","number":"No.1","starting_page":"79","ending_page":"84","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmccrj.cr.2020-0123"],"issn":["2188-4226"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33360523","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=381126","label":"url"}],"paper_title":{"en":"Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke.","ja":"Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke."},"authors":{"en":[{"name":"Ishihara Manabu"},{"name":"Nakanishi Nobuto"},{"name":"Tsutsumi Rie"},{"name":"Hara Kanako"},{"name":"Machida Kyoka"},{"name":"Yamamoto Nobuaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Sakaue Hiroshi"},{"name":"Oto Jun"},{"name":"Takagi Yasushi"}],"ja":[{"name":"石原 学"},{"name":"中西 信人"},{"name":"堤 理恵"},{"name":"原 加奈子"},{"name":"待田 京香"},{"name":"山本 伸昭"},{"name":"兼松 康久"},{"name":"阪上 浩"},{"name":"大藤 純"},{"name":"髙木 康志"}]},"description":{"en":"Urinary titin rapidly increased after stroke and was associated with impaired functional outcomes at hospital discharge.","ja":"Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7-21.1), 16.2 (8.6-22.0), 8.9 (4.8-15.2), and 8.7 (3.6-16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = -0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03)."},"publication_date":"2021-03","publication_name":{"en":"Journal of Stroke & Cerebrovascular Diseases","ja":"Journal of Stroke & Cerebrovascular Diseases"},"volume":"Vol.30","number":"No.3","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jstrokecerebrovasdis.2020.105561"],"issn":["1532-8511"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116496","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34759146","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391517","label":"url"}],"paper_title":{"en":"Continued-Maintenance Therapy with High-dose Methotrexate Improves Overall Survival of Patients with Primary Central Nervous System Lymphoma.","ja":"Continued-Maintenance Therapy with High-dose Methotrexate Improves Overall Survival of Patients with Primary Central Nervous System Lymphoma."},"authors":{"en":[{"name":"Nakajima Kohhei"},{"name":"Mizobuchi Yoshifumi"},{"name":"Fujihara Toshitaka"},{"name":"Azumi Mai"},{"name":"Takagi Yasushi"}],"ja":[{"name":"中島 公平"},{"name":"溝渕 佳史"},{"name":"藤原 敏孝"},{"name":"安積 麻衣"},{"name":"髙木 康志"}]},"description":{"en":"In 3-year overall survival (OS) there was a statistically significant difference between the two groups [controls : 33.1% (95%, CI 12.4 - 55.7%) ; maintenance group : 74.9% (95%, CI 55.6 - 86.7%) (p < 0.02)]. Conclusion : The induction of HD-MTX based chemotherapy followed by continued-maintenance HD-MTX monotherapy improved OS compared with chemoradiotherapy consisting of HD-MTX followed by WBRT. J. Med. Invest. 68 : 286-291, August, 2021.","ja":"In 3-year overall survival (OS) there was a statistically significant difference between the two groups [controls : 33.1% (95%, CI 12.4 - 55.7%) ; maintenance group : 74.9% (95%, CI 55.6 - 86.7%) (p < 0.02)]. Conclusion : The induction of HD-MTX based chemotherapy followed by continued-maintenance HD-MTX monotherapy improved OS compared with chemoradiotherapy consisting of HD-MTX followed by WBRT. J. Med. Invest. 68 : 286-291, August, 2021."},"publication_date":"2021","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.3.4","starting_page":"286","ending_page":"291","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.286"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116574","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34759169","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=388976","label":"url"}],"paper_title":{"en":"Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings.","ja":"Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings."},"authors":{"en":[{"name":"Tabuena Ma Daisy"},{"name":"Morigaki Ryoma"},{"name":"Miyamoto Ryosuke"},{"name":"Mure Hideo"},{"name":"Yamamoto Nobuaki"},{"name":"Miyake Kazuhisa"},{"name":"Matsuda Taku"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"},{"name":"Tabuena Rollin P"},{"name":"Kawarai Toshitaka"}],"ja":[{"name":"Tabuena Ma Daisy"},{"name":"森垣 龍馬"},{"name":"宮本 亮介"},{"name":"牟礼 英生"},{"name":"山本 伸昭"},{"name":"三宅 一央"},{"name":"松田 拓"},{"name":"和泉 唯信"},{"name":"髙木 康志"},{"name":"Tabuena Rollin P"},{"name":"瓦井 俊孝"}]},"description":{"en":"Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021.","ja":"Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021."},"publication_date":"2021","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.3.4","starting_page":"400","ending_page":"403","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.400"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382925","label":"url"}],"paper_title":{"en":"Gelatinthrombin Hemostatic Matrix-related Cyst Formation after Cerebral Hematoma Evacuation: A Report of Two Cases","ja":"Gelatinthrombin Hemostatic Matrix-related Cyst Formation after Cerebral Hematoma Evacuation: A Report of Two Cases"},"authors":{"en":[{"name":"Yamaguchi Izumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Nakajima Kohhei"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Shikata Eiji"},{"name":"Ishihara Manabu"},{"name":"Azumi Mai"},{"name":"Kageyama Ayato"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 泉"},{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"中島 公平"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"四方 英二"},{"name":"石原 学"},{"name":"安積 麻衣"},{"name":"蔭山 彩人"},{"name":"髙木 康志"}]},"publication_date":"2021","publication_name":{"en":"NMC Case Report Journal","ja":"NMC Case Report Journal"},"volume":"Vol.8","number":"No.1","starting_page":"719","ending_page":"725","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmccrj.cr.2021-0130"],"issn":["2188-4226"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33161217","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377245","label":"url"}],"paper_title":{"en":"Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion","ja":"Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion"},"authors":{"en":[{"name":"Yamamoto Nobuaki"},{"name":"Izumi Yuishin"},{"name":"Yamamoto Yuki"},{"name":"Kuroda K"},{"name":"Yamaguchi Izumi"},{"name":"Sogabe Shu"},{"name":"Miyamoto Takeshi"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Morigaki Ryoma"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山本 伸昭"},{"name":"和泉 唯信"},{"name":"山本 雄貴"},{"name":"黒田 一駿"},{"name":"山口 泉"},{"name":"曽我部 周"},{"name":"宮本 健志"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"森垣 龍馬"},{"name":"髙木 康志"}]},"description":{"en":"The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission.","ja":"The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission."},"publication_date":"2020-10-16","publication_name":{"en":"Clinical Neurology and Neurosurgery","ja":"Clinical Neurology and Neurosurgery"},"volume":"Vol.199","starting_page":"106316","ending_page":"106316","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.clineuro.2020.106316"],"issn":["1872-6968"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117722","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32943658","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391519","label":"url"}],"paper_title":{"en":"Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.","ja":"Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma."},"authors":{"en":[{"name":"Shono Kenji"},{"name":"Yamaguchi Izumi"},{"name":"Mizobuchi Yoshifumi"},{"name":"Kagusa Hiroshi"},{"name":"Sumi Akiko"},{"name":"Fujihara Toshitaka"},{"name":"Nakajima Kohhei"},{"name":"Kitazato Keiko T"},{"name":"Matsuzaki Kazuhito"},{"name":"Saya Hideyuki"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Shono Kenji"},{"name":"山口 泉"},{"name":"溝渕 佳史"},{"name":"鹿草 宏"},{"name":"Sumi Akiko"},{"name":"藤原 敏孝"},{"name":"中島 公平"},{"name":"Kitazato Keiko T"},{"name":"松﨑 和仁"},{"name":"Saya Hideyuki"},{"name":"髙木 康志"}]},"description":{"en":"microglia. In GSCs, celecoxib inhibited Ccl2 and Cxcr3 expression in a nuclear factor-kappa B-dependent manner but not Ccr2 and CxcL10. Moreover, Ccl2 silencing resulted in decreased GSC viability. These results suggest that celecoxib-mediated regulation of the CCL2/CCR2 and CXCL10/ CXCR3 axes may partially contribute to glioma-specific antitumor effects.","ja":"Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C-C motif ligand 2 (CCL2), C-X-C ligand 10 (CXCL10), and their receptors, CCR2 and CXCR3, in GSCs and a GSC-bearing malignant glioma model. C57BL/6 mice were injected with orthotopic GSCs intracranially and divided into groups administered either 10 or 30 mg/kg celecoxib, or saline to examine the antitumor effects associated with chemokine expression. In GSCs, we analyzed cell viability and expression of chemokines and their receptors in the presence/absence of celecoxib. In the malignant glioma model, celecoxib exhibited antitumor effects in a dose dependent manner and decreased protein and mRNA levels of Ccl2 and CxcL10 and Cxcr3 but not of Ccr2. CCL2 and CXCL10 co-localized with Nestin"},"publication_date":"2020-09-17","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.10","number":"No.1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-020-71857-3"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116502","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32942724","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377527","label":"url"}],"paper_title":{"en":"Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components.","ja":"Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components."},"authors":{"en":[{"name":"Morigaki Ryoma"},{"name":"Miyamoto Ryosuke"},{"name":"Mure Hideo"},{"name":"Fujita Koji"},{"name":"Matsuda Taku"},{"name":"Yamamoto Yoko"},{"name":"Nakataki Masahito"},{"name":"Okahisa Tetsuya"},{"name":"Matsumoto Yuki"},{"name":"Miyake Kazuhisa"},{"name":"Yamamoto Nobuaki"},{"name":"Kaji Ryuji"},{"name":"Takagi Yasushi"},{"name":"Goto Satoshi"}],"ja":[{"name":"森垣 龍馬"},{"name":"宮本 亮介"},{"name":"牟礼 英生"},{"name":"藤田 浩司"},{"name":"Matsuda Taku"},{"name":"Yamamoto Yoko"},{"name":"中瀧 理仁"},{"name":"Okahisa Tetsuya"},{"name":"松元 友暉"},{"name":"三宅 一央"},{"name":"山本 伸昭"},{"name":"梶 龍兒"},{"name":"髙木 康志"},{"name":"後藤 惠"}]},"description":{"en":"The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.","ja":"The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery."},"publication_date":"2020-09-15","publication_name":{"en":"Brain Sciences","ja":"Brain Sciences"},"volume":"Vol.10","number":"No.9","starting_page":"636","ending_page":"636","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/brainsci10090636"],"issn":["2076-3425"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32894852","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=380931","label":"url"}],"paper_title":{"en":"Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature.","ja":"Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature."},"authors":{"en":[{"name":"Mure Hideo"},{"name":"Toyoda Naoto"},{"name":"Morigaki Ryoma"},{"name":"Fujita Koji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"牟礼 英生"},{"name":"Toyoda Naoto"},{"name":"森垣 龍馬"},{"name":"藤田 浩司"},{"name":"髙木 康志"}]},"description":{"en":"Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS.","ja":"Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS."},"publication_date":"2020-09-07","publication_name":{"en":"Stereotactic and Functional Neurosurgery","ja":"Stereotactic and Functional Neurosurgery"},"volume":"Vol.98","number":"No.6","starting_page":"399","ending_page":"403","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000509318"],"issn":["1423-0372"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366698","label":"url"}],"paper_title":{"en":"Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner","ja":"Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner"},"authors":{"en":[{"name":"Kanazawa Yuki"},{"name":"Harada Masafumi"},{"name":"Miyoshi Mitsuharu"},{"name":"Abe Takashi"},{"name":"Matsumoto Yuki"},{"name":"Takagi Yasushi"}],"ja":[{"name":"金澤 裕樹"},{"name":"原田 雅史"},{"name":"Miyoshi Mitsuharu"},{"name":"阿部 考志"},{"name":"松元 友暉"},{"name":"髙木 康志"}]},"publication_date":"2020-08","publication_name":{"en":"Proceedings of the 28th Virtual Conference of ISMRM","ja":"Proceedings of the 28th Virtual Conference of ISMRM"},"number":"No.1697","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366696","label":"url"}],"paper_title":{"en":"Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques","ja":"Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques"},"authors":{"en":[{"name":"Kanazawa Yuki"},{"name":"Harada Masafumi"},{"name":"Miyati Tosiaki"},{"name":"Abe Takashi"},{"name":"Miyoshi Mitsuharu"},{"name":"Matsumoto Yuki"},{"name":"Hayashi Hiroaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"金澤 裕樹"},{"name":"原田 雅史"},{"name":"Miyati Tosiaki"},{"name":"阿部 考志"},{"name":"Miyoshi Mitsuharu"},{"name":"松元 友暉"},{"name":"林 裕晃"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"publication_date":"2020-08","publication_name":{"en":"Proceedings of 28th Virtual Meeting of ISMRM","ja":"Proceedings of 28th Virtual Meeting of ISMRM"},"number":"No.2128","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115292","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=367257","label":"url"}],"paper_title":{"en":"Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage","ja":"Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage"},"authors":{"en":[{"name":"Yoshioka Shotaroh"},{"name":"Miyamoto Takeshi"},{"name":"Satomi Junichiro"},{"name":"Tada Yoshiteru"},{"name":"Yagi Kenji"},{"name":"Shimada Kenji"},{"name":"Naruishi Koji"},{"name":"Shikata Eiji"},{"name":"Yamaguchi Izumi"},{"name":"Yamaguchi Tadashi"},{"name":"Korai Masaaki"},{"name":"Okayama Yoshihiro"},{"name":"Harada Masafumi"},{"name":"Kitazato Keiko"},{"name":"Kanematsu Yasuhisa"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"?岡 正太郎"},{"name":"宮本 健志"},{"name":"里見 淳一郎"},{"name":"多田 恵曜"},{"name":"八木 謙次"},{"name":"島田 健司"},{"name":"成石 浩司"},{"name":"四方 英二"},{"name":"山口 泉"},{"name":"山口 真司"},{"name":"高麗 雅章"},{"name":"Okayama Yoshihiro"},{"name":"原田 雅史"},{"name":"北里 慶子"},{"name":"兼松 康久"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"publication_date":"2020-07-23","publication_name":{"en":"Neurosurgery Open","ja":"Neurosurgery Open"},"volume":"Vol.1","number":"No.3","starting_page":"1","ending_page":"9","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1093/neuopn/okaa007"],"issn":["2633-0873"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115806","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32248771","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366209","label":"url"}],"paper_title":{"en":"Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial.","ja":"Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial."},"authors":{"en":[{"name":"Masatoshi Koga"},{"name":"Haruko Yamamoto"},{"name":"Manabu Inoue"},{"name":"Koko Asakura"},{"name":"Junya Aoki"},{"name":"Toshimitsu Hamasaki"},{"name":"Takao Kanzawa"},{"name":"Rei Kondo"},{"name":"Masafumi Ohtaki"},{"name":"Ryo Itabashi"},{"name":"Kenji Kamiyama"},{"name":"Toru Iwama"},{"name":"Taizen Nakase"},{"name":"Yusuke Yakushiji"},{"name":"Shuichi Igarashi"},{"name":"Yoshinari Nagakane"},{"name":"Shunya Takizawa"},{"name":"Yasushi Okada"},{"name":"Ryosuke Doijiri"},{"name":"Akira Tsujino"},{"name":"Yasuhiro Ito"},{"name":"Hideyuki Ohnishi"},{"name":"Takeshi Inoue"},{"name":"Takagi Yasushi"},{"name":"Yasuhiro Hasegawa"},{"name":"Yoshiaki Shiokawa"},{"name":"Nobuyuki Sakai"},{"name":"Masato Osaki"},{"name":"Yoshikazu Uesaka"},{"name":"Shinichi Yoshimura"},{"name":"Takao Urabe"},{"name":"Toshihiro Ueda"},{"name":"Masafumi Ihara"},{"name":"Takanari Kitazono"},{"name":"Makoto Sasaki"},{"name":"Akira Oita"},{"name":"Sohei Yoshimura"},{"name":"Mayumi Fukuda-Doi"},{"name":"Kaori Miwa"},{"name":"Kazumi Kimura"},{"name":"Kazuo Minematsu"},{"name":"Kazunori Toyoda"},{"name":"THAWS Trial Investigators"}],"ja":[{"name":"Masatoshi Koga"},{"name":"Haruko Yamamoto"},{"name":"Manabu Inoue"},{"name":"Koko Asakura"},{"name":"Junya Aoki"},{"name":"Toshimitsu Hamasaki"},{"name":"Takao Kanzawa"},{"name":"Rei Kondo"},{"name":"Masafumi Ohtaki"},{"name":"Ryo Itabashi"},{"name":"Kenji Kamiyama"},{"name":"Toru Iwama"},{"name":"Taizen Nakase"},{"name":"Yusuke Yakushiji"},{"name":"Shuichi Igarashi"},{"name":"Yoshinari Nagakane"},{"name":"Shunya Takizawa"},{"name":"Yasushi Okada"},{"name":"Ryosuke Doijiri"},{"name":"Akira Tsujino"},{"name":"Yasuhiro Ito"},{"name":"Hideyuki Ohnishi"},{"name":"Takeshi Inoue"},{"name":"髙木 康志"},{"name":"Yasuhiro Hasegawa"},{"name":"Yoshiaki Shiokawa"},{"name":"Nobuyuki Sakai"},{"name":"Masato Osaki"},{"name":"Yoshikazu Uesaka"},{"name":"Shinichi Yoshimura"},{"name":"Takao Urabe"},{"name":"Toshihiro Ueda"},{"name":"Masafumi Ihara"},{"name":"Takanari Kitazono"},{"name":"Makoto Sasaki"},{"name":"Akira Oita"},{"name":"Sohei Yoshimura"},{"name":"Mayumi Fukuda-Doi"},{"name":"Kaori Miwa"},{"name":"Kazumi Kimura"},{"name":"Kazuo Minematsu"},{"name":"Kazunori Toyoda"},{"name":"THAWS Trial Investigators"}]},"description":{"en":"Background and Purpose- We assessed whether lower-dose alteplase at 0.6 mg/kg is efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with unknown time of onset. Methods- This was an investigator-initiated, multicenter, randomized, open-label, blinded-end point trial. Patients met the standard indication criteria for intravenous thrombolysis other than a time last-known-well >4.5 hours (eg, wake-up stroke). Patients were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg or standard medical treatment if magnetic resonance imaging showed acute ischemic lesion on diffusion-weighted imaging and no marked corresponding hyperintensity on fluid-attenuated inversion recovery. The primary outcome was a favorable outcome (90-day modified Rankin Scale score of 0-1). Results- Following the early stop and positive results of the WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke), this trial was prematurely terminated with 131 of the anticipated 300 patients (55 women; mean age, 74.4±12.2 years). Favorable outcome was comparable between the alteplase group (32/68, 47.1%) and the control group (28/58, 48.3%; relative risk [RR], 0.97 [95% CI, 0.68-1.41]; =0.892). Symptomatic intracranial hemorrhage within 22 to 36 hours occurred in 1/71 and 0/60 (RR, infinity [95% CI, 0.06 to infinity]; >0.999), respectively. Death at 90 days occurred in 2/71 and 2/60 (RR, 0.85 [95% CI, 0.06-12.58]; >0.999), respectively. Conclusions- No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset. The safety of alteplase at 0.6 mg/kg was comparable to that of standard treatment. Early study termination precludes any definitive conclusions. Registration- URL: https://www.clinicaltrials.gov; Unique identifier: NCT02002325.","ja":"Background and Purpose- We assessed whether lower-dose alteplase at 0.6 mg/kg is efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with unknown time of onset. Methods- This was an investigator-initiated, multicenter, randomized, open-label, blinded-end point trial. Patients met the standard indication criteria for intravenous thrombolysis other than a time last-known-well >4.5 hours (eg, wake-up stroke). Patients were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg or standard medical treatment if magnetic resonance imaging showed acute ischemic lesion on diffusion-weighted imaging and no marked corresponding hyperintensity on fluid-attenuated inversion recovery. The primary outcome was a favorable outcome (90-day modified Rankin Scale score of 0-1). Results- Following the early stop and positive results of the WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke), this trial was prematurely terminated with 131 of the anticipated 300 patients (55 women; mean age, 74.4±12.2 years). Favorable outcome was comparable between the alteplase group (32/68, 47.1%) and the control group (28/58, 48.3%; relative risk [RR], 0.97 [95% CI, 0.68-1.41]; =0.892). Symptomatic intracranial hemorrhage within 22 to 36 hours occurred in 1/71 and 0/60 (RR, infinity [95% CI, 0.06 to infinity]; >0.999), respectively. Death at 90 days occurred in 2/71 and 2/60 (RR, 0.85 [95% CI, 0.06-12.58]; >0.999), respectively. Conclusions- No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset. The safety of alteplase at 0.6 mg/kg was comparable to that of standard treatment. Early study termination precludes any definitive conclusions. Registration- URL: https://www.clinicaltrials.gov; Unique identifier: NCT02002325."},"publication_date":"2020-05","publication_name":{"en":"Stroke","ja":"Stroke"},"volume":"Vol.51","number":"No.5","starting_page":"1530","ending_page":"1538","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1161/STROKEAHA.119.028127"],"issn":["1524-4628"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32234334","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366203","label":"url"}],"paper_title":{"en":"Action observation treatment improves gait ability in subacute to convalescent stroke patients.","ja":"Action observation treatment improves gait ability in subacute to convalescent stroke patients."},"authors":{"en":[{"name":"Hioka Akemi"},{"name":"Tada Yoshiteru"},{"name":"Kitazato Keiko"},{"name":"Akazawa Naoki"},{"name":"Takagi Yasushi"},{"name":"Nagahiro Shinji"}],"ja":[{"name":"Hioka Akemi"},{"name":"多田 恵曜"},{"name":"Kitazato Keiko"},{"name":"Akazawa Naoki"},{"name":"髙木 康志"},{"name":"永廣 信治"}]},"description":{"en":"The aim of this study was to investigate the effects of action observation treatment (AOT) on gait ability in patients with subacute to convalescent stroke. Sixteen patients with subacute stroke were divided into a control group (n = 8) and AOT group (n = 8) when admitted to the convalescent ward. The control group received a conventional rehabilitation only. In addition to conventional rehabilitation, the AOT received AOT for 3 months (30 min per day 5 times per week). The AOT involved observing the action of another subject in a comfortable gait situation from the front, sides, and back via video and conducting the actual action. All participants were assessed during the main-assessment period, which included a baseline (i.e., when admitted to the convalescent ward) and 1, 2, and 3 months after baseline. The sub-assessment period at 2 and 3 months after baseline was conducted with participants who could walk independently. The main outcomes of the main-assessment and sub-assessment periods were Functional Ambulation Classification (FAC) and the 10-m walk test (10MWT), respectively. With respect to the FAC, we used a split plot design analysis of covariance to test the interaction between assessment time and group. There was no significant interaction between assessment time and group in FAC. However, a significant improvement of the 10MWT in the sub-assessment period was observed in the AOT group, but not the control group. Our results indicate that AOT may be an effective therapy for patients with subacute to convalescent stroke who can walk independently.","ja":"The aim of this study was to investigate the effects of action observation treatment (AOT) on gait ability in patients with subacute to convalescent stroke. Sixteen patients with subacute stroke were divided into a control group (n = 8) and AOT group (n = 8) when admitted to the convalescent ward. The control group received a conventional rehabilitation only. In addition to conventional rehabilitation, the AOT received AOT for 3 months (30 min per day 5 times per week). The AOT involved observing the action of another subject in a comfortable gait situation from the front, sides, and back via video and conducting the actual action. All participants were assessed during the main-assessment period, which included a baseline (i.e., when admitted to the convalescent ward) and 1, 2, and 3 months after baseline. The sub-assessment period at 2 and 3 months after baseline was conducted with participants who could walk independently. The main outcomes of the main-assessment and sub-assessment periods were Functional Ambulation Classification (FAC) and the 10-m walk test (10MWT), respectively. With respect to the FAC, we used a split plot design analysis of covariance to test the interaction between assessment time and group. There was no significant interaction between assessment time and group in FAC. However, a significant improvement of the 10MWT in the sub-assessment period was observed in the AOT group, but not the control group. Our results indicate that AOT may be an effective therapy for patients with subacute to convalescent stroke who can walk independently."},"publication_date":"2020-05","publication_name":{"en":"Journal of Clinical Neuroscience","ja":"Journal of Clinical Neuroscience"},"volume":"Vol.75","starting_page":"55","ending_page":"61","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jocn.2020.03.031"],"issn":["1532-2653"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115918","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32238726","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366204","label":"url"}],"paper_title":{"en":"Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6.","ja":"Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6."},"authors":{"en":[{"name":"Yuki Yamamoto"},{"name":"Yamamoto Nobuaki"},{"name":"Fujita Koji"},{"name":"Tatsuya Fukumoto"},{"name":"Nagahisa Murakami"},{"name":"Mure Hideo"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Izumi Yuishin"}],"ja":[{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"藤田 浩司"},{"name":"Tatsuya Fukumoto"},{"name":"Nagahisa Murakami"},{"name":"牟礼 英生"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"和泉 唯信"}]},"publication_date":"2020-04","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.59","number":"No.14","starting_page":"1749","ending_page":"1753","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.4388-20"],"issn":["0918-2918"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31445814","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85070874852&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363935","label":"url"}],"paper_title":{"en":"Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion","ja":"Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion"},"authors":{"en":[{"name":"Yamamoto Nobuaki"},{"name":"Yamamoto Yuki"},{"name":"Yamaguchi Izumi"},{"name":"Ishihara Manabu"},{"name":"Miyamoto Takeshi"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山本 伸昭"},{"name":"山本 雄貴"},{"name":"山口 泉"},{"name":"石原 学"},{"name":"宮本 健志"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO.","ja":"Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO."},"publication_date":"2019-12","publication_name":{"en":"Journal of Clinical Neuroscience","ja":"Journal of Clinical Neuroscience"},"volume":"Vol.70","starting_page":"67","ending_page":"71","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jocn.2019.08.078"],"issn":["1532-2653"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115057","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31760390","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85075786196&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363937","label":"url"}],"paper_title":{"en":"Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke","ja":"Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke"},"authors":{"en":[{"name":"Yamaguchi Izumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Korai Masaaki"},{"name":"Miyamoto Takeshi"},{"name":"Shikata Eiji"},{"name":"Yamaguchi Tadashi"},{"name":"Yamamoto Nobuaki"},{"name":"Yamamoto Yuki"},{"name":"Kitazato Keiko"},{"name":"Okayama Yoshihiro"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 泉"},{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"高麗 雅章"},{"name":"宮本 健志"},{"name":"四方 英二"},{"name":"山口 真司"},{"name":"山本 伸昭"},{"name":"山本 雄貴"},{"name":"北里 慶子"},{"name":"Okayama Yoshihiro"},{"name":"髙木 康志"}]},"description":{"en":"Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS.","ja":"Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS."},"publication_date":"2019-11-22","publication_name":{"en":"Cerebrovascular Diseases Extra","ja":"Cerebrovascular Diseases Extra"},"volume":"Vol.9","number":"No.3","starting_page":"129","ending_page":"138","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000504163"],"issn":["1664-5456"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31318323","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366193","label":"url"}],"paper_title":{"en":"A follow-up study of the effect of training using the Hybrid Assistive Limb on Gait ability in chronic stroke patients.","ja":"A follow-up study of the effect of training using the Hybrid Assistive Limb on Gait ability in chronic stroke patients."},"authors":{"en":[{"name":"Hiroki Tanaka"},{"name":"Manabu Nankaku"},{"name":"Toru Nishikawa"},{"name":"Honami Yonezawa"},{"name":"Hiroki Mori"},{"name":"Takayuki Kikuchi"},{"name":"Hidehisa Nishi"},{"name":"Takagi Yasushi"},{"name":"Susumu Miyamoto"},{"name":"Ryosuke Ikeguchi"},{"name":"Shuichi Matsuda"}],"ja":[{"name":"Hiroki Tanaka"},{"name":"Manabu Nankaku"},{"name":"Toru Nishikawa"},{"name":"Honami Yonezawa"},{"name":"Hiroki Mori"},{"name":"Takayuki Kikuchi"},{"name":"Hidehisa Nishi"},{"name":"髙木 康志"},{"name":"Susumu Miyamoto"},{"name":"Ryosuke Ikeguchi"},{"name":"Shuichi Matsuda"}]},"description":{"en":": Recently, use of the Hybrid Assistive Limb (HAL) that is effective for improvement of gait ability in chronic stroke patients has been reported. However, how long the effects are maintained remains unknown. The purpose of the present study was to investigate whether the effect of gait training using the HAL on gait ability was maintained for 3 months after the intervention. : A longitudinal, observational study with an intervention for a single group that adhered to the STROBE guidelines was performed. Nine chronic stroke patients were enrolled in this study. The patients performed gait training sessions using the HAL, 2-5 sessions/week for 3 weeks. Gait speed, stride length, cadence, and 2-minute walk distance (2MWD) were measured before and after intervention and at 3-month follow-up. The clinical trial registration number of this study is UMIN000012764 R000014756. : Compared to the initial status, gait speed ( = .02), stride length ( = .03), cadence ( = .01), and 2MWD ( < .05) were significantly increased immediately after the intervention. Moreover, gait speed ( < .01), cadence ( = .03), and 2MWD ( = .02) remained significantly higher 3 months after the intervention. There were no significant changes in all outcome measures between after intervention and at 3-month follow-up. : This study showed that gait training using the HAL resulted in significant improvement of gait ability after the intervention and the effect was maintained for 3 months after the training.","ja":": Recently, use of the Hybrid Assistive Limb (HAL) that is effective for improvement of gait ability in chronic stroke patients has been reported. However, how long the effects are maintained remains unknown. The purpose of the present study was to investigate whether the effect of gait training using the HAL on gait ability was maintained for 3 months after the intervention. : A longitudinal, observational study with an intervention for a single group that adhered to the STROBE guidelines was performed. Nine chronic stroke patients were enrolled in this study. The patients performed gait training sessions using the HAL, 2-5 sessions/week for 3 weeks. Gait speed, stride length, cadence, and 2-minute walk distance (2MWD) were measured before and after intervention and at 3-month follow-up. The clinical trial registration number of this study is UMIN000012764 R000014756. : Compared to the initial status, gait speed ( = .02), stride length ( = .03), cadence ( = .01), and 2MWD ( < .05) were significantly increased immediately after the intervention. Moreover, gait speed ( < .01), cadence ( = .03), and 2MWD ( = .02) remained significantly higher 3 months after the intervention. There were no significant changes in all outcome measures between after intervention and at 3-month follow-up. : This study showed that gait training using the HAL resulted in significant improvement of gait ability after the intervention and the effect was maintained for 3 months after the training."},"publication_date":"2019-10","publication_name":{"en":"Topics in Stroke Rehabilitation","ja":"Topics in Stroke Rehabilitation"},"volume":"Vol.26","number":"No.7","starting_page":"491","ending_page":"496","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/10749357.2019.1640001"],"issn":["1945-5119"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31295589","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366192","label":"url"}],"paper_title":{"en":"Rare Case of Concurrent Glossopharyngeal and Trigeminal Neuralgia, in Which Glossopharyngeal Neuralgia was Possibly Induced by Postoperative Changes Following Microvascular Decompression for Trigeminal Neuralgia.","ja":"Rare Case of Concurrent Glossopharyngeal and Trigeminal Neuralgia, in Which Glossopharyngeal Neuralgia was Possibly Induced by Postoperative Changes Following Microvascular Decompression for Trigeminal Neuralgia."},"authors":{"en":[{"name":"Maki Yoshinori"},{"name":"Kikuchi Takayuki"},{"name":"Komatsu Katsuya"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Maki Yoshinori"},{"name":"Kikuchi Takayuki"},{"name":"Komatsu Katsuya"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"}]},"description":{"en":"Glossopharyngeal neuralgia (GPN) and trigeminal neuralgia (TN) can result from mechanical stimulation of the glossopharyngeal nerve (GPNv) and trigeminal nerve (TNv) by blood vessels. TN can cause severe pain in the orofacial region, whereas GPN manifests as pain in the tongue, throat, tonsil, and ear. Although these 2 neuralgias can occur concurrently, concurrence of recurrent TN and GPN that develops postoperatively has not been previously described. A 68-year-old male complained of right glossalgia and pain in the pharynx radiating to the right auricular area. The patient had previously undergone microvascular decompression (MVD) for right TN. Medication and intraoral xylocaine spray did not relieve the symptoms. An oral surgeon was unable to find any disease related to the glossalgia. The anesthesiologist pointed out that the symptoms could be from partial recurrence of the TN because the patient also complained of pain in the inferior alveolus. Magnetic resonance angiography indicated that the right GPNv seemed to be compressed by the right posterior inferior cerebellar artery (PICA); hence, MVD for both GPN and TN was performed. Intraoperatively, the right PICA was found to be adherent to the GPNv because of the thickened arachnoid membrane and was subsequently detached. The TNv was also examined, but only a Teflon ball was found, which was detached from the TNv. The GPN disappeared postoperatively, although TN persisted after the second operation. GPN can result from adhesions between the GPNv and arachnoid membrane following previous MVD.","ja":"Glossopharyngeal neuralgia (GPN) and trigeminal neuralgia (TN) can result from mechanical stimulation of the glossopharyngeal nerve (GPNv) and trigeminal nerve (TNv) by blood vessels. TN can cause severe pain in the orofacial region, whereas GPN manifests as pain in the tongue, throat, tonsil, and ear. Although these 2 neuralgias can occur concurrently, concurrence of recurrent TN and GPN that develops postoperatively has not been previously described. A 68-year-old male complained of right glossalgia and pain in the pharynx radiating to the right auricular area. The patient had previously undergone microvascular decompression (MVD) for right TN. Medication and intraoral xylocaine spray did not relieve the symptoms. An oral surgeon was unable to find any disease related to the glossalgia. The anesthesiologist pointed out that the symptoms could be from partial recurrence of the TN because the patient also complained of pain in the inferior alveolus. Magnetic resonance angiography indicated that the right GPNv seemed to be compressed by the right posterior inferior cerebellar artery (PICA); hence, MVD for both GPN and TN was performed. Intraoperatively, the right PICA was found to be adherent to the GPNv because of the thickened arachnoid membrane and was subsequently detached. The TNv was also examined, but only a Teflon ball was found, which was detached from the TNv. The GPN disappeared postoperatively, although TN persisted after the second operation. GPN can result from adhesions between the GPNv and arachnoid membrane following previous MVD."},"publication_date":"2019-10","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.130","starting_page":"150","ending_page":"153","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2019.06.216"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113804","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31518986","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363938","label":"url"}],"paper_title":{"en":"Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model","ja":"Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model"},"authors":{"en":[{"name":"Yamaguchi Tadashi"},{"name":"Miyamoto Takeshi"},{"name":"Kitazato keiko"},{"name":"Shikata Eiji"},{"name":"Yamaguchi Izumi"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Yagi Kenji"},{"name":"Tada Yoshiteru"},{"name":"Matsuzaki Yoshihito"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 真司"},{"name":"宮本 健志"},{"name":"北里 慶子"},{"name":"四方 英二"},{"name":"山口 泉"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"八木 謙次"},{"name":"多田 恵曜"},{"name":"松崎 慶仁"},{"name":"兼松 康久"},{"name":"髙木 康志"}]},"description":{"en":"The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture.","ja":"The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture."},"publication_date":"2019-09-13","publication_name":{"en":"Journal of Neurosurgery","ja":"Journal of Neurosurgery"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.3171/2019.6.JNS19777"],"issn":["1933-0693"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31132492","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366191","label":"url"}],"paper_title":{"en":"Importance of Managing the Water-Electrolyte Balance by Delivering the Optimal Minimum Amount of Water and Sodium After Subarachnoid Hemorrhage.","ja":"Importance of Managing the Water-Electrolyte Balance by Delivering the Optimal Minimum Amount of Water and Sodium After Subarachnoid Hemorrhage."},"authors":{"en":[{"name":"Shikata Eiji"},{"name":"Tamura Tetsuya"},{"name":"Shinno Kiyohito"},{"name":"Okayama Yoshihiro"},{"name":"Shinohara Naoki"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Kitazato T Keiko"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Shikata Eiji"},{"name":"Tamura Tetsuya"},{"name":"Shinno Kiyohito"},{"name":"Okayama Yoshihiro"},{"name":"Shinohara Naoki"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"Kitazato T Keiko"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"After aneurysmal subarachnoid hemorrhage (aSAH), crystalloid fluids with a relatively high sodium concentration have been used to maintain the cerebral blood flow. However, the prophylactic delivery of water and sodium by intravenous (IV) infusion will not necessarily improve the prognosis of patients after aSAH, and the excessive supply of water and sodium can negatively affect the outcome. We hypothesized that the delivery of an optimal amount of water and sodium separately might improve the outcome after aSAH. We recruited 55 consecutive patients who had undergone clipping or endovascular coil embolization after aSAH. Group 1 (n = 33) received conventional therapy (i.e., prophylactic IV sodium and water [protocol 1]). Group 2 (n = 22) received the optimal amount of water and sodium separately (protocol 2). The median total of water and sodium chloride supplied in group 1 was significantly greater than that supplied in group 2 (P < 0.01). The modified Rankin scale score at discharge was 0-2 in 15 patients (95%) in group 2 and 23 patients (55%) in group 1 (P < 0.001). On multivariate logistic regression analysis, the odds ratio for a discharge modified Rankin scale score of 0-2 or 3-6 was significantly associated with the treatment protocol (P < 0.05) and the net fluid balance on days 4-8 (P < 0.05). The separate delivery of optimal amounts of water and sodium could be a promising therapeutic strategy to improve the prognosis after aSAH.","ja":"After aneurysmal subarachnoid hemorrhage (aSAH), crystalloid fluids with a relatively high sodium concentration have been used to maintain the cerebral blood flow. However, the prophylactic delivery of water and sodium by intravenous (IV) infusion will not necessarily improve the prognosis of patients after aSAH, and the excessive supply of water and sodium can negatively affect the outcome. We hypothesized that the delivery of an optimal amount of water and sodium separately might improve the outcome after aSAH. We recruited 55 consecutive patients who had undergone clipping or endovascular coil embolization after aSAH. Group 1 (n = 33) received conventional therapy (i.e., prophylactic IV sodium and water [protocol 1]). Group 2 (n = 22) received the optimal amount of water and sodium separately (protocol 2). The median total of water and sodium chloride supplied in group 1 was significantly greater than that supplied in group 2 (P < 0.01). The modified Rankin scale score at discharge was 0-2 in 15 patients (95%) in group 2 and 23 patients (55%) in group 1 (P < 0.001). On multivariate logistic regression analysis, the odds ratio for a discharge modified Rankin scale score of 0-2 or 3-6 was significantly associated with the treatment protocol (P < 0.05) and the net fluid balance on days 4-8 (P < 0.05). The separate delivery of optimal amounts of water and sodium could be a promising therapeutic strategy to improve the prognosis after aSAH."},"publication_date":"2019-09","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.129","starting_page":"e352","ending_page":"e360","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2019.05.152"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30891830","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366110","label":"url"}],"paper_title":{"en":"Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells","ja":"Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells"},"authors":{"en":[{"name":"Yulius Hermanto"},{"name":"Maki Takakuni"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"},{"name":"Takahashi Jun"}],"ja":[{"name":"Yulius Hermanto"},{"name":"Maki Takakuni"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"},{"name":"Takahashi Jun"}]},"description":{"en":"Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disorders for which brain-derived OPCs are more appropriate than spinal cord-derived OPCs. Furthermore, animal-derived components are responsible for culture variability in the derivation and complicate clinical translation. In the present study, we established a xeno-free system to induce forebrain OPCs from hPSCs. We induced human forebrain neural stem cells (NSCs) on Laminin 511-E8 and directed the differentiation to the developmental pathway for forebrain OLs with SHH and FGF signaling. OPCs were characterized by the expression of OLIG2, NKX2.2, SOX10, and PDGFRA, and subsequent maturation into O4 cells. In vitro characterization showed that >85% of the forebrain OPCs (O4 ) underwent maturation into OLs (MBP ) 3 weeks after mitogen removal. Upon intracranial transplantation, the OPCs survived, dispersed in the corpus callosum, and matured into (GSTϖ ) OLs in the host brains 3 months after transplantation. These findings suggest our xeno-free induction of forebrain OPCs from hPSCs could accelerate clinical translation for brain-specific disorders.","ja":"Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disorders for which brain-derived OPCs are more appropriate than spinal cord-derived OPCs. Furthermore, animal-derived components are responsible for culture variability in the derivation and complicate clinical translation. In the present study, we established a xeno-free system to induce forebrain OPCs from hPSCs. We induced human forebrain neural stem cells (NSCs) on Laminin 511-E8 and directed the differentiation to the developmental pathway for forebrain OLs with SHH and FGF signaling. OPCs were characterized by the expression of OLIG2, NKX2.2, SOX10, and PDGFRA, and subsequent maturation into O4 cells. In vitro characterization showed that >85% of the forebrain OPCs (O4 ) underwent maturation into OLs (MBP ) 3 weeks after mitogen removal. Upon intracranial transplantation, the OPCs survived, dispersed in the corpus callosum, and matured into (GSTϖ ) OLs in the host brains 3 months after transplantation. These findings suggest our xeno-free induction of forebrain OPCs from hPSCs could accelerate clinical translation for brain-specific disorders."},"publication_date":"2019-07","publication_name":{"en":"Journal of Neuroscience Research","ja":"Journal of Neuroscience Research"},"volume":"Vol.97","number":"No.7","starting_page":"828","ending_page":"845","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/jnr.24413"],"issn":["1097-4547"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31061257","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366188","label":"url"}],"paper_title":{"en":"A Single-center Retrospective Study with 5- and 10-year Follow-up of Carotid Endarterectomy with Patch Graft.","ja":"A Single-center Retrospective Study with 5- and 10-year Follow-up of Carotid Endarterectomy with Patch Graft."},"authors":{"en":[{"name":"Okazaki Toshiyuki"},{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Korai Masaaki"},{"name":"Satomi Junichiro"},{"name":"Uno Masaaki"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"岡﨑 敏之"},{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"高麗 雅章"},{"name":"里見 淳一郎"},{"name":"宇野 昌明"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"Carotid endarterectomy (CEA) is widely used for cervical artery stenosis. In Japan, primary closure after endarterectomy has been a standard technique. Recently, the patch closure has been shown to be superior to the primary suture for the prevention of restenosis and ipsilateral stroke. This study evaluated the 5- and 10-year outcomes following CEA with patch graft closure in our institution. Between January 2000 and March 2013, 134 patients, who underwent CEA with patch graft closure were investigated in the current retrospective study. Among these patients, 102 CEAs in 97 patients were followed up for 5 years and 66 CEAs in 61 patients were for 10 years after the procedure. Restenosis was defined as >50% recurrent luminal narrowing at the endarterectomy site. In 5 years, symptomatic restenosis exhibited minor stroke in one patient at 58 months after CEA (restenosis rate 1.0%). The ipsilateral minor stroke occurred in three patients including the above case (2.9%). In 10 years, asymptomatic restenosis occurred in three patients in addition to the above symptomatic case (restenosis rate 6.1%), and the ipsilateral minor stroke occurred in four patients (6.1%). Carotid endarterectomy with patch graft exerted a high protective effect from restenosis up to 5 and 10 years in our institution. The number of carotid artery stenting is increasing all over the world but we speculated that the established surgical procedure of patched CEA prevented restenosis and ipsilateral stroke.","ja":"Carotid endarterectomy (CEA) is widely used for cervical artery stenosis. In Japan, primary closure after endarterectomy has been a standard technique. Recently, the patch closure has been shown to be superior to the primary suture for the prevention of restenosis and ipsilateral stroke. This study evaluated the 5- and 10-year outcomes following CEA with patch graft closure in our institution. Between January 2000 and March 2013, 134 patients, who underwent CEA with patch graft closure were investigated in the current retrospective study. Among these patients, 102 CEAs in 97 patients were followed up for 5 years and 66 CEAs in 61 patients were for 10 years after the procedure. Restenosis was defined as >50% recurrent luminal narrowing at the endarterectomy site. In 5 years, symptomatic restenosis exhibited minor stroke in one patient at 58 months after CEA (restenosis rate 1.0%). The ipsilateral minor stroke occurred in three patients including the above case (2.9%). In 10 years, asymptomatic restenosis occurred in three patients in addition to the above symptomatic case (restenosis rate 6.1%), and the ipsilateral minor stroke occurred in four patients (6.1%). Carotid endarterectomy with patch graft exerted a high protective effect from restenosis up to 5 and 10 years in our institution. The number of carotid artery stenting is increasing all over the world but we speculated that the established surgical procedure of patched CEA prevented restenosis and ipsilateral stroke."},"publication_date":"2019-06-15","publication_name":{"en":"Neurologia Medico-Chirurgica","ja":"Neurologia Medico-Chirurgica"},"volume":"Vol.59","number":"No.6","starting_page":"231","ending_page":"237","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmc.oa.2018-0309"],"issn":["1349-8029"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30902772","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366112","label":"url"}],"paper_title":{"en":"KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations","ja":"KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations"},"authors":{"en":[{"name":"Oka Mieko"},{"name":"Kushamae Mika"},{"name":"Aoki Tomohiro"},{"name":"Yamaguchi Tadashi"},{"name":"Kitazato Keiko"},{"name":"Abekura Yu"},{"name":"Kawamata Takakazu"},{"name":"Mizutani Tohru"},{"name":"Susumu Miyamoto"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Oka Mieko"},{"name":"Kushamae Mika"},{"name":"Aoki Tomohiro"},{"name":"Yamaguchi Tadashi"},{"name":"Kitazato Keiko"},{"name":"Abekura Yu"},{"name":"Kawamata Takakazu"},{"name":"Mizutani Tohru"},{"name":"Susumu Miyamoto"},{"name":"髙木 康志"}]},"description":{"en":"Brain arteriovenous malformations (BAVMs) are vascular malformations composed of tangles of abnormally developed vasculature without capillaries. Abnormal shunting of arteries and veins is formed, resulting in high-pressure vascular channels, which potentially lead to rupture. BAVMs are generally considered a congenital disorder. But clinical evidence regarding involution, regrowth, and de novo formation argue against the static condition of this disease. Recently, the presence of the somatic activating KRAS mutations in more than half of BAVM cases was reported, suggesting the role of KRAS function in the pathogenesis. KRAS mutation in codon35 (G→A, G12D; G→T, G12V) was examined by a digital polymerase chain reaction analysis using genome purified from paraffin-embedded slides of human BAVMs. We also examined protein expression of KRAS G12D in lesions to corroborate results from digital polymerase chain reaction analysis. We detected codon35 G→A mutation in 15 (39.5%) among 38 samples and codon35 G→T mutation in 10 (27.0%) among 37 samples we could assess mutations. There were no samples positive for both codon35 G→A and G→T mutation. The ratio of codon35 G→A mutation ranged from 0.60% to 12.28% and that of G→T was from 1.20% to 8.99%. We next examined protein expression of KRAS G12D in BAVM lesions in immunohistochemistry. A KRAS G12D mutant was detected mainly in endothelial cells of dilated vessels in lesions. KRAS mutations in codon35 were detected in about two thirds of specimens examined. KRAS function may actively contribute to the pathobiology of BAVM and can become a therapeutic target.","ja":"Brain arteriovenous malformations (BAVMs) are vascular malformations composed of tangles of abnormally developed vasculature without capillaries. Abnormal shunting of arteries and veins is formed, resulting in high-pressure vascular channels, which potentially lead to rupture. BAVMs are generally considered a congenital disorder. But clinical evidence regarding involution, regrowth, and de novo formation argue against the static condition of this disease. Recently, the presence of the somatic activating KRAS mutations in more than half of BAVM cases was reported, suggesting the role of KRAS function in the pathogenesis. KRAS mutation in codon35 (G→A, G12D; G→T, G12V) was examined by a digital polymerase chain reaction analysis using genome purified from paraffin-embedded slides of human BAVMs. We also examined protein expression of KRAS G12D in lesions to corroborate results from digital polymerase chain reaction analysis. We detected codon35 G→A mutation in 15 (39.5%) among 38 samples and codon35 G→T mutation in 10 (27.0%) among 37 samples we could assess mutations. There were no samples positive for both codon35 G→A and G→T mutation. The ratio of codon35 G→A mutation ranged from 0.60% to 12.28% and that of G→T was from 1.20% to 8.99%. We next examined protein expression of KRAS G12D in BAVM lesions in immunohistochemistry. A KRAS G12D mutant was detected mainly in endothelial cells of dilated vessels in lesions. KRAS mutations in codon35 were detected in about two thirds of specimens examined. KRAS function may actively contribute to the pathobiology of BAVM and can become a therapeutic target."},"publication_date":"2019-06","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.126","starting_page":"e1365","ending_page":"e1373","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2019.03.105"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115571","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31020902","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85065291909&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366187","label":"url"}],"paper_title":{"en":"Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia.","ja":"Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia."},"authors":{"en":[{"name":"Kishida Natsue"},{"name":"Maki Takakuni"},{"name":"Takagi Yasushi"},{"name":"Yasuda Ken"},{"name":"Kinoshita Hisanori"},{"name":"Ayaki Takashi"},{"name":"Noro Takayuki"},{"name":"Kinoshita Yusuke"},{"name":"Ono Yuichi"},{"name":"Kataoka Hiroharu"},{"name":"Yoshida Kazumichi"},{"name":"Lo H. Eng"},{"name":"Arai Ken"},{"name":"Miyamoto Susumu"},{"name":"Takahashi Ryosuke"}],"ja":[{"name":"Kishida Natsue"},{"name":"Maki Takakuni"},{"name":"髙木 康志"},{"name":"Yasuda Ken"},{"name":"Kinoshita Hisanori"},{"name":"Ayaki Takashi"},{"name":"Noro Takayuki"},{"name":"Kinoshita Yusuke"},{"name":"Ono Yuichi"},{"name":"Kataoka Hiroharu"},{"name":"Yoshida Kazumichi"},{"name":"Lo H. Eng"},{"name":"Arai Ken"},{"name":"Miyamoto Susumu"},{"name":"Takahashi Ryosuke"}]},"description":{"en":"Background Oligodendrocyte precursor cells ( OPC s) regulate neuronal, glial, and vascular systems in diverse ways and display phenotypic heterogeneity beyond their established role as a reservoir for mature oligodendrocytes. However, the detailed phenotypic changes of OPC s after cerebral ischemia remain largely unknown. Here, we aimed to investigate the roles of reactive OPC s in the ischemic brain. Methods and Results The behavior of OPC s was evaluated in a mouse model of ischemic stroke produced by transient middle cerebral artery occlusion in vivo. For in vitro experiments, the phenotypic change of OPC s after oxygen glucose derivation was examined using a primary rat OPC culture. Furthermore, the therapeutic potential of hypoxic OPC s was evaluated in a mouse model of middle cerebral artery occlusion in vivo. Perivascular OPC s in the cerebral cortex were increased alongside poststroke angiogenesis in a mouse model of middle cerebral artery occlusion. In vitro RNA -seq analysis revealed that primary cultured OPC s increased the gene expression of numerous pro-angiogenic factors after oxygen glucose derivation. Hypoxic OPC s secreted a greater amount of pro-angiogenic factors, such as vascular endothelial growth factor and angiopoietin-1, compared with normoxic OPC s. Hypoxic OPC -derived conditioned media increased the viability and tube formation of endothelial cells. In vivo studies also demonstrated that 5 consecutive daily treatments with hypoxic OPC -conditioned media, beginning 2 days after middle cerebral artery occlusion, facilitated poststroke angiogenesis, alleviated infarct volume, and improved functional disabilities. Conclusions Following cerebral ischemia, the phenotype of OPC s in the cerebral cortex shifts from the parenchymal subtype to the perivascular subtype, which can promote angiogenesis. The optimal use of hypoxic OPC s secretome would provide a novel therapeutic option for stroke.","ja":"Background Oligodendrocyte precursor cells ( OPC s) regulate neuronal, glial, and vascular systems in diverse ways and display phenotypic heterogeneity beyond their established role as a reservoir for mature oligodendrocytes. However, the detailed phenotypic changes of OPC s after cerebral ischemia remain largely unknown. Here, we aimed to investigate the roles of reactive OPC s in the ischemic brain. Methods and Results The behavior of OPC s was evaluated in a mouse model of ischemic stroke produced by transient middle cerebral artery occlusion in vivo. For in vitro experiments, the phenotypic change of OPC s after oxygen glucose derivation was examined using a primary rat OPC culture. Furthermore, the therapeutic potential of hypoxic OPC s was evaluated in a mouse model of middle cerebral artery occlusion in vivo. Perivascular OPC s in the cerebral cortex were increased alongside poststroke angiogenesis in a mouse model of middle cerebral artery occlusion. In vitro RNA -seq analysis revealed that primary cultured OPC s increased the gene expression of numerous pro-angiogenic factors after oxygen glucose derivation. Hypoxic OPC s secreted a greater amount of pro-angiogenic factors, such as vascular endothelial growth factor and angiopoietin-1, compared with normoxic OPC s. Hypoxic OPC -derived conditioned media increased the viability and tube formation of endothelial cells. In vivo studies also demonstrated that 5 consecutive daily treatments with hypoxic OPC -conditioned media, beginning 2 days after middle cerebral artery occlusion, facilitated poststroke angiogenesis, alleviated infarct volume, and improved functional disabilities. Conclusions Following cerebral ischemia, the phenotype of OPC s in the cerebral cortex shifts from the parenchymal subtype to the perivascular subtype, which can promote angiogenesis. The optimal use of hypoxic OPC s secretome would provide a novel therapeutic option for stroke."},"publication_date":"2019-05-07","publication_name":{"en":"Journal of the American Heart Association","ja":"Journal of the American Heart Association"},"volume":"Vol.8","number":"No.9","starting_page":"e011824","ending_page":"e011824","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1161/JAHA.118.011824"],"issn":["2047-9980"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30880348","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85063028221&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366105","label":"url"}],"paper_title":{"en":"Restoration of Periventricular Vasculature After Direct Bypass for Moyamoya Disease: Intra-Individual Comparison","ja":"Restoration of Periventricular Vasculature After Direct Bypass for Moyamoya Disease: Intra-Individual Comparison"},"authors":{"en":[{"name":"Miyakoshi Akinori"},{"name":"Funaki Takeshi"},{"name":"Takahashi Jun C"},{"name":"Takagi Yasushi"},{"name":"Kikuchi Takayuki"},{"name":"Yoshida Kazumichi"},{"name":"Kataoka Hiroharu"},{"name":"Mineharu Yohei"},{"name":"Okawa Masakazu"},{"name":"Yamao Yukihiro"},{"name":"Fushimi Yasutaka"},{"name":"Okada Tomohisa"},{"name":"Togashi Kaori"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Miyakoshi Akinori"},{"name":"Funaki Takeshi"},{"name":"Takahashi Jun C"},{"name":"髙木 康志"},{"name":"Kikuchi Takayuki"},{"name":"Yoshida Kazumichi"},{"name":"Kataoka Hiroharu"},{"name":"Mineharu Yohei"},{"name":"Okawa Masakazu"},{"name":"Yamao Yukihiro"},{"name":"Fushimi Yasutaka"},{"name":"Okada Tomohisa"},{"name":"Togashi Kaori"},{"name":"Miyamoto Susumu"}]},"description":{"en":"While periventricular anastomosis, a unique abnormal vasculature in moyamoya disease, has been studied in relation to intracranial hemorrhage, no study has addressed its change after bypass surgery. The authors sought to test whether direct bypass surgery could restore normal periventricular vasculature. Patients who had undergone direct bypass surgery for moyamoya disease at a single institution were eligible for the study. Baseline, postoperative, and follow-up magnetic resonance angiography (MRA) scans were scheduled before surgery, after the first surgery, and 3 to 6 months after contralateral second surgery, respectively. Sliding-thin-slab maximum-intensity-projection coronal MRA images of periventricular anastomoses were scored according to the three subtypes (lenticulostriate, thalamic, and choroidal anastomosis). Baseline and postoperative MRA images were compared to obtain a matched comparison of score changes in the surgical and nonsurgical hemispheres within individuals (intra-individual comparison). Of 110 patients, 42 were identified for intra-individual comparisons. The periventricular anastomosis score decreased significantly in the surgical hemispheres (median, 2 versus 1; p < 0.001), whereas the score remained unchanged in the nonsurgical hemispheres (median, 2 versus 2; p = 0.57); the score change varied significantly between the surgical and nonsurgical hemispheres (p < 0.001). Of the 104 periventricular-anastomosis-positive hemispheres undergoing surgery, 47 (45.2%) were assessed as negative in the follow-up MRA. Among the subtypes, choroidal anastomosis was most likely to be assessed as negative (79.7% of positive hemispheres). Periventricular vasculature can be restored after direct bypass. The likelihood of correction of choroidal anastomosis is a subject requiring further studies.","ja":"While periventricular anastomosis, a unique abnormal vasculature in moyamoya disease, has been studied in relation to intracranial hemorrhage, no study has addressed its change after bypass surgery. The authors sought to test whether direct bypass surgery could restore normal periventricular vasculature. Patients who had undergone direct bypass surgery for moyamoya disease at a single institution were eligible for the study. Baseline, postoperative, and follow-up magnetic resonance angiography (MRA) scans were scheduled before surgery, after the first surgery, and 3 to 6 months after contralateral second surgery, respectively. Sliding-thin-slab maximum-intensity-projection coronal MRA images of periventricular anastomoses were scored according to the three subtypes (lenticulostriate, thalamic, and choroidal anastomosis). Baseline and postoperative MRA images were compared to obtain a matched comparison of score changes in the surgical and nonsurgical hemispheres within individuals (intra-individual comparison). Of 110 patients, 42 were identified for intra-individual comparisons. The periventricular anastomosis score decreased significantly in the surgical hemispheres (median, 2 versus 1; p < 0.001), whereas the score remained unchanged in the nonsurgical hemispheres (median, 2 versus 2; p = 0.57); the score change varied significantly between the surgical and nonsurgical hemispheres (p < 0.001). Of the 104 periventricular-anastomosis-positive hemispheres undergoing surgery, 47 (45.2%) were assessed as negative in the follow-up MRA. Among the subtypes, choroidal anastomosis was most likely to be assessed as negative (79.7% of positive hemispheres). Periventricular vasculature can be restored after direct bypass. The likelihood of correction of choroidal anastomosis is a subject requiring further studies."},"publication_date":"2019-05","publication_name":{"en":"Acta Neurochirurgica","ja":"Acta Neurochirurgica"},"volume":"Vol.161","number":"No.5","starting_page":"947","ending_page":"954","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00701-019-03866-9"],"issn":["0942-0940"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30814423","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365932","label":"url"}],"paper_title":{"en":"Ex Vivo Assessment of Various Histological Differentiation in Human Carotid Plaque with Near-infrared Spectroscopy Using Multiple Wavelengths.","ja":"Ex Vivo Assessment of Various Histological Differentiation in Human Carotid Plaque with Near-infrared Spectroscopy Using Multiple Wavelengths."},"authors":{"en":[{"name":"Munemitsu Toshihiro"},{"name":"Ishii Akira"},{"name":"Okada Eiji"},{"name":"Chihara Hideo"},{"name":"Yoshida Kazumichi"},{"name":"Takahashi C Jun"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Munemitsu Toshihiro"},{"name":"Ishii Akira"},{"name":"Okada Eiji"},{"name":"Chihara Hideo"},{"name":"Yoshida Kazumichi"},{"name":"Takahashi C Jun"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"}]},"description":{"en":"We previously reported that near-infrared hyperspectral imaging enabled the localization of atherosclerotic plaques from outside the vessels, but not the optical characteristics of each histological component. Therefore, the near-infrared spectrum of each component was collected from the sliced section of the human carotid plaque obtained with endarterectomy and the optical characteristics were confirmed in several wavelengths. Based on this information, we assessed the diagnostic accuracy for ex vivo chemogram in each plaque component created with near-infrared spectroscopy (NIRS), using multiple wavelengths. The chemogram projected on the actual image of plaque was created based on light intensity and transmittance change at three wavelengths. The wavelengths that were mainly were 1440, 1620, 1730, and 1930 nm. We evaluated the accuracy of histological diagnosis in chemogram compared with pathological findings, analyzing interobserver agreement with κ-statistics. The chemograms that we created depicted the components of fibrous tissue, smooth muscle, lipid tissue, intraplaque hemorrhage, and calcification. Diagnostic odds ratio in each component was as follows: 259.6 in fibrous tissue, 144 in smooth muscle, 1123.5 in lipid tissue, 29.3 in intraplaque hemorrhage, and 136.3 in calcification. The κ-statistics revealed that four components, excluding intraplaque hemorrhage, had substantial or almost perfect agreement. Thus, this study demonstrated the feasibility of using chemogram focused on specific component during the histological assessment of atherosclerotic plaques, highlighting its potential diagnostic ability. Chemograms of various target components can be created by combining multiple wavelengths. This technology may prove to be useful in improving the histological assessment of plaque using NIRS.","ja":"We previously reported that near-infrared hyperspectral imaging enabled the localization of atherosclerotic plaques from outside the vessels, but not the optical characteristics of each histological component. Therefore, the near-infrared spectrum of each component was collected from the sliced section of the human carotid plaque obtained with endarterectomy and the optical characteristics were confirmed in several wavelengths. Based on this information, we assessed the diagnostic accuracy for ex vivo chemogram in each plaque component created with near-infrared spectroscopy (NIRS), using multiple wavelengths. The chemogram projected on the actual image of plaque was created based on light intensity and transmittance change at three wavelengths. The wavelengths that were mainly were 1440, 1620, 1730, and 1930 nm. We evaluated the accuracy of histological diagnosis in chemogram compared with pathological findings, analyzing interobserver agreement with κ-statistics. The chemograms that we created depicted the components of fibrous tissue, smooth muscle, lipid tissue, intraplaque hemorrhage, and calcification. Diagnostic odds ratio in each component was as follows: 259.6 in fibrous tissue, 144 in smooth muscle, 1123.5 in lipid tissue, 29.3 in intraplaque hemorrhage, and 136.3 in calcification. The κ-statistics revealed that four components, excluding intraplaque hemorrhage, had substantial or almost perfect agreement. Thus, this study demonstrated the feasibility of using chemogram focused on specific component during the histological assessment of atherosclerotic plaques, highlighting its potential diagnostic ability. Chemograms of various target components can be created by combining multiple wavelengths. This technology may prove to be useful in improving the histological assessment of plaque using NIRS."},"publication_date":"2019-05","publication_name":{"en":"Neurologia Medico-Chirurgica","ja":"Neurologia Medico-Chirurgica"},"volume":"Vol.59","number":"No.5","starting_page":"163","ending_page":"171","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmc.oa.2018-0203"],"issn":["1349-8029"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114639","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30930237","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366167","label":"url"}],"paper_title":{"en":"The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion.","ja":"The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion."},"authors":{"en":[{"name":"Yuki Yamamoto"},{"name":"Yamamoto Nobuaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Izumi Yuishin"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Yuki Yamamoto"},{"name":"山本 伸昭"},{"name":"兼松 康久"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"和泉 唯信"},{"name":"髙木 康志"}]},"description":{"en":"Mechanical thrombectomy undoubtedly improves functional outcomes for patients with acute ischemic stroke. Although we have observed occlusion sites that protrude proximally into the vessel on angiography, termed the \"claw sign,\" we have been unable to state its clinical significance. In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. We retrospectively included 73 consecutive patients treated for acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. The angiographic claw sign was defined as a thrombus that protruded proximally by more than half the diameter of the parent artery. Claw sign positivity, clinical and etiological features, and outcomes were compared between groups with and without recanalization. The claw sign was observed in 29 of 73 (40%) patients and was positive significantly more frequently in those with recanalization (50.0%) than in those without recanalization (5.9%) (P < .01). By multivariate analysis, the claw sign was the only pretreatment parameter to predict successful recanalization (odds ratio, 12.50; 95% confidence interval, 1.50-103.00; P = .019). The presence of the claw sign might predict successful recanalization in patients undergoing mechanical thrombectomy for large vessel occlusion.","ja":"Mechanical thrombectomy undoubtedly improves functional outcomes for patients with acute ischemic stroke. Although we have observed occlusion sites that protrude proximally into the vessel on angiography, termed the \"claw sign,\" we have been unable to state its clinical significance. In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. We retrospectively included 73 consecutive patients treated for acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. The angiographic claw sign was defined as a thrombus that protruded proximally by more than half the diameter of the parent artery. Claw sign positivity, clinical and etiological features, and outcomes were compared between groups with and without recanalization. The claw sign was observed in 29 of 73 (40%) patients and was positive significantly more frequently in those with recanalization (50.0%) than in those without recanalization (5.9%) (P < .01). By multivariate analysis, the claw sign was the only pretreatment parameter to predict successful recanalization (odds ratio, 12.50; 95% confidence interval, 1.50-103.00; P = .019). The presence of the claw sign might predict successful recanalization in patients undergoing mechanical thrombectomy for large vessel occlusion."},"publication_date":"2019-03-28","publication_name":{"en":"Journal of Stroke & Cerebrovascular Diseases","ja":"Journal of Stroke & Cerebrovascular Diseases"},"volume":"Vol.28","number":"No.6","starting_page":"1555","ending_page":"1560","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jstrokecerebrovasdis.2019.03.007"],"issn":["1532-8511"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113267","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30318398","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365931","label":"url"}],"paper_title":{"en":"Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons.","ja":"Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons."},"authors":{"en":[{"name":"Hioka Akemi"},{"name":"Tada Yoshiteru"},{"name":"Kitazato Keiko"},{"name":"Kanematsu Yasuhisa"},{"name":"Mizobuchi Yoshifumi"},{"name":"Mure Hideo"},{"name":"Shimada Kenji"},{"name":"Okazaki Toshiyuki"},{"name":"Korai Masaaki"},{"name":"Akazawa Noki"},{"name":"Matsumoto Yuki"},{"name":"Matsumoto Yuki"},{"name":"Takagi Yasushi"},{"name":"Nagahiro Shinji"}],"ja":[{"name":"Hioka Akemi"},{"name":"多田 恵曜"},{"name":"Kitazato Keiko"},{"name":"兼松 康久"},{"name":"溝渕 佳史"},{"name":"牟礼 英生"},{"name":"島田 健司"},{"name":"岡﨑 敏之"},{"name":"高麗 雅章"},{"name":"Akazawa Noki"},{"name":"松元 友暉"},{"name":"松元 友暉"},{"name":"髙木 康志"},{"name":"永廣 信治"}]},"description":{"en":"The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training.","ja":"The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training."},"publication_date":"2019-02","publication_name":{"en":"Journal of Clinical Neuroscience","ja":"Journal of Clinical Neuroscience"},"volume":"Vol.60","starting_page":"79","ending_page":"83","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jocn.2018.09.035"],"issn":["1532-2653"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390001288147947776/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373166","label":"url"}],"paper_title":{"en":"Simultaneous approach to tandem occlusion in acute ischemic stroke patients: Percutaneous Transluminal Angioplasty (PTA) using push wire of stent retriever","ja":"Simultaneous approach to tandem occlusion in acute ischemic stroke patients: Percutaneous Transluminal Angioplasty (PTA) using push wire of stent retriever"},"authors":{"en":[{"name":"Yamamoto Nobuaki"},{"name":"Yamamoto Yuki"},{"name":"Korai Masaaki"},{"name":"Shimada Kenji"},{"name":"Kanematsu Yasuhisa"},{"name":"Izumi Yuishin"},{"name":"Satomi Junichiro"},{"name":"Takagi Yasushi"},{"name":"Kaji Ryuji"}],"ja":[{"name":"山本 伸昭"},{"name":"山本 雄貴"},{"name":"高麗 雅章"},{"name":"島田 健司"},{"name":"兼松 康久"},{"name":"和泉 唯信"},{"name":"里見 淳一郎"},{"name":"髙木 康志"},{"name":"梶 龍兒"}]},"publication_date":"2019","publication_name":{"en":"Journal of Neuroendovascular Therapy","ja":"Journal of Neuroendovascular Therapy"},"volume":"Vol.13","number":"No.6","starting_page":"257","ending_page":"261","languages":["eng"],"referee":true,"identifiers":{"doi":["10.5797/jnet.cr.2018-0108"],"issn":["1882-4072"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114169","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31656305","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366196","label":"url"}],"paper_title":{"en":"Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report.","ja":"Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report."},"authors":{"en":[{"name":"Kagusa Hiroshi"},{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Fujihara Toshitaka"},{"name":"Bando Yoshimi"},{"name":"Takagi Yasushi"}],"ja":[{"name":"鹿草 宏"},{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"藤原 敏孝"},{"name":"Bando Yoshimi"},{"name":"髙木 康志"}]},"description":{"en":"Metastatic tumors to the orbit of the eye, especially from primary carcinomas of the uterine cervix are very rare. A 64-year-old woman with a history of carcinoma of the uterine cervix presented with right eye pain and blepharoptosis for 2 weeks. Magnetic resonance imaging revealed a mass at the right orbital apex. Surgical extirpation was performed due to severe pain. Postoperative pathology demonstrated a poorly differentiated squamous cell carcinoma. The origin was ultimately considered to be the carcinoma of the uterine cervix. In conclusion, this report describes a rare case of a metastatic tumor at the orbital apex derived from the cervix of the uterus. J. Med. Invest. 66 : 355-357, August, 2019.","ja":"Metastatic tumors to the orbit of the eye, especially from primary carcinomas of the uterine cervix are very rare. A 64-year-old woman with a history of carcinoma of the uterine cervix presented with right eye pain and blepharoptosis for 2 weeks. Magnetic resonance imaging revealed a mass at the right orbital apex. Surgical extirpation was performed due to severe pain. Postoperative pathology demonstrated a poorly differentiated squamous cell carcinoma. The origin was ultimately considered to be the carcinoma of the uterine cervix. In conclusion, this report describes a rare case of a metastatic tumor at the orbital apex derived from the cervix of the uterus. J. Med. Invest. 66 : 355-357, August, 2019."},"publication_date":"2019","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.66","number":"No.3,4","starting_page":"355","ending_page":"357","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.66.355"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114088","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31656296","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366195","label":"url"}],"paper_title":{"en":"The risk of hemorrhage in stereotactic biopsy for brain tumors.","ja":"The risk of hemorrhage in stereotactic biopsy for brain tumors."},"authors":{"en":[{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Fujihara Toshitaka"},{"name":"Matsuzaki Kazuhito"},{"name":"Mure Hideo"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"藤原 敏孝"},{"name":"松﨑 和仁"},{"name":"牟礼 英生"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"Objective : One major complication associated with STB is intratumoral hematoma, which is also the most common cause of morbidity related to permanent paralysis and mortality in STB. The risk of perioperative hemorrhage is generally between 1% and 10%, but this could be an underestimation since it is not common for many neurosurgeons to perform CT scans after uncomplicated STBs. In this study, we describe the incidence of cerebral hemorrhage, including asymptomatic cerebral hemorrhage. Methods : We recently reviewed data on the diagnosis rate and occurrence of complications, including symptomatic and asymptomatic cerebral hemorrhage, in 80 patients who underwent STB at our facility between 2005 and 2014. Results : Histological diagnosis was established for 75 cases (93.8%), glioma was the most frequently encountered tumor. Symptomatic hemorrhage was observed in two cases (2.6%), with the symptoms subsiding within two days. The morbidity and mortality rate was 0%. However, asymptomatic hemorrhages were observed in 23 cases (28.8%). Conclusion : Stereotactic biopsy is a less invasive procedure for obtaining samples of brain tumors for diagnosis. The bleeding of the tissue-resection cavity that includes asymptomatic hemorrhage occurs at a constant rate. It is important to reduce the symptomatic bleeding associated with stereotactic biopsy. J. Med. Invest. 66 : 314-318, August, 2019.","ja":"Objective : One major complication associated with STB is intratumoral hematoma, which is also the most common cause of morbidity related to permanent paralysis and mortality in STB. The risk of perioperative hemorrhage is generally between 1% and 10%, but this could be an underestimation since it is not common for many neurosurgeons to perform CT scans after uncomplicated STBs. In this study, we describe the incidence of cerebral hemorrhage, including asymptomatic cerebral hemorrhage. Methods : We recently reviewed data on the diagnosis rate and occurrence of complications, including symptomatic and asymptomatic cerebral hemorrhage, in 80 patients who underwent STB at our facility between 2005 and 2014. Results : Histological diagnosis was established for 75 cases (93.8%), glioma was the most frequently encountered tumor. Symptomatic hemorrhage was observed in two cases (2.6%), with the symptoms subsiding within two days. The morbidity and mortality rate was 0%. However, asymptomatic hemorrhages were observed in 23 cases (28.8%). Conclusion : Stereotactic biopsy is a less invasive procedure for obtaining samples of brain tumors for diagnosis. The bleeding of the tissue-resection cavity that includes asymptomatic hemorrhage occurs at a constant rate. It is important to reduce the symptomatic bleeding associated with stereotactic biopsy. J. Med. Invest. 66 : 314-318, August, 2019."},"publication_date":"2019","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.66","number":"No.3,4","starting_page":"314","ending_page":"318","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.66.314"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30367252","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85055887945&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=354185","label":"url"}],"paper_title":{"en":"Ruptured intranidal aneurysm of an arteriovenous malformation diagnosed by delay alternating with nutation for tailored excitation (DANTE)-prepared contrast-enhanced magnetic resonance imaging","ja":"Ruptured intranidal aneurysm of an arteriovenous malformation diagnosed by delay alternating with nutation for tailored excitation (DANTE)-prepared contrast-enhanced magnetic resonance imaging"},"authors":{"en":[{"name":"Komatsu K"},{"name":"Takagi Yasushi"},{"name":"Kikuchi T"},{"name":"Yamao Y"},{"name":"Fushimi Y"},{"name":"Grinstead J"},{"name":"Ahn S"},{"name":"Miyamoto S"}],"ja":[{"name":"Komatsu K"},{"name":"髙木 康志"},{"name":"Kikuchi T"},{"name":"Yamao Y"},{"name":"Fushimi Y"},{"name":"Grinstead J"},{"name":"Ahn S"},{"name":"宮本 亨"}]},"description":{"en":"This case report describes the usefulness of delay alternating with nutation for tailored excitation (DANTE)-prepared, contrast-enhanced magnetic resonance imaging (CE-MRI) for detecting the rupture site of an arteriovenous malformation (AVM). A ruptured intranidal aneurysm was confirmed histopathologically. Accurate non-invasive information about the possible rupture site of an AVM is critical for optimal treatment and evaluation. Vessel wall enhancement visualized by DANTE-prepared CE-MRI may be a useful tool for providing information about changes in inflammatory status and vulnerability to further developments.","ja":"This case report describes the usefulness of delay alternating with nutation for tailored excitation (DANTE)-prepared, contrast-enhanced magnetic resonance imaging (CE-MRI) for detecting the rupture site of an arteriovenous malformation (AVM). A ruptured intranidal aneurysm was confirmed histopathologically. Accurate non-invasive information about the possible rupture site of an AVM is critical for optimal treatment and evaluation. Vessel wall enhancement visualized by DANTE-prepared CE-MRI may be a useful tool for providing information about changes in inflammatory status and vulnerability to further developments."},"publication_date":"2018-12","publication_name":{"en":"Acta Neurochirurgica","ja":"Acta Neurochirurgica"},"volume":"Vol.160","number":"No.12","starting_page":"2435","ending_page":"2438","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00701-018-3713-7"],"issn":["0942-0940"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30298831","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=348778","label":"url"}],"paper_title":{"en":"Microdiscectomy and Foraminotomy in Cervical Spondylotic Myelopathy and Radiculopathy","ja":"Microdiscectomy and Foraminotomy in Cervical Spondylotic Myelopathy and Radiculopathy"},"authors":{"en":[{"name":"Okazaki Toshiyuki"},{"name":"Nakagawa H"},{"name":"Mure Hideo"},{"name":"Yagi Kenji"},{"name":"Hayase H"},{"name":"Takagi Yasushi"},{"name":"Saito K"}],"ja":[{"name":"岡﨑 敏之"},{"name":"Nakagawa H"},{"name":"牟礼 英生"},{"name":"八木 謙次"},{"name":"Hayase H"},{"name":"髙木 康志"},{"name":"Saito K"}]},"description":{"en":"This study was to assess the efficacy of microdiscectomy, cage fixation, and right tranuncal foramintomy for the patients suffering from right radiulo-myelopathy. Anterior cervical foraminotomy was reported to be an effective option for the treatment of cervical degenerative radiculopathy but with the problem of recurrence. Since Hakuba reported the method of trans-unco-discal approach in 1976, it was designed as keyhole foraminotomy which was called transuncal approach, transpedicular approach or transvertebral approach. In the anterior approach, we usually use the right-sided approach because most of us are right-handed surgeons. We retrospectively investigated our patients who had the right foraminal stenosis causing radiculopathy and were treated with microdiscectomy, cage fixation, and right keyhole transuncal foraminotomy. Since 2011, 23 patients were treated with the manner. All of the 23 patients who had central canal stenosis and among the 23 patients, 8 patients showed only right radiculopathy and 15 patients showed radiculo-myelopathy. In all patients, the radiculopathy disappeared or significantly improved without any complications postoperatively. The average of VAS scores was 7.6 ± 2.2 in preoperative state, 2.8 ± 2.2 at discharge, and 1.1 ± 1.6 in 1 month after surgery. The average of follow-up time was 38.3 months and they had no recurrence of radiculopathy. We showed that this manner is effective and one option for the combined disease of right foraminal and canal stenosis and we believe that this manner is not complex and safe if we can understand the anatomy.","ja":"This study was to assess the efficacy of microdiscectomy, cage fixation, and right tranuncal foramintomy for the patients suffering from right radiulo-myelopathy. Anterior cervical foraminotomy was reported to be an effective option for the treatment of cervical degenerative radiculopathy but with the problem of recurrence. Since Hakuba reported the method of trans-unco-discal approach in 1976, it was designed as keyhole foraminotomy which was called transuncal approach, transpedicular approach or transvertebral approach. In the anterior approach, we usually use the right-sided approach because most of us are right-handed surgeons. We retrospectively investigated our patients who had the right foraminal stenosis causing radiculopathy and were treated with microdiscectomy, cage fixation, and right keyhole transuncal foraminotomy. Since 2011, 23 patients were treated with the manner. All of the 23 patients who had central canal stenosis and among the 23 patients, 8 patients showed only right radiculopathy and 15 patients showed radiculo-myelopathy. In all patients, the radiculopathy disappeared or significantly improved without any complications postoperatively. The average of VAS scores was 7.6 ± 2.2 in preoperative state, 2.8 ± 2.2 at discharge, and 1.1 ± 1.6 in 1 month after surgery. The average of follow-up time was 38.3 months and they had no recurrence of radiculopathy. We showed that this manner is effective and one option for the combined disease of right foraminal and canal stenosis and we believe that this manner is not complex and safe if we can understand the anatomy."},"publication_date":"2018-10-06","publication_name":{"en":"Neurologia Medico-Chirurgica","ja":"Neurologia Medico-Chirurgica"},"volume":"Vol.58","number":"No.11","starting_page":"468","ending_page":"476","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmc.oa.2018-0077"],"issn":["1349-8029"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=348775","label":"url"}],"paper_title":{"en":"脳震盪の病態と最近の話題","ja":"脳震盪の病態と最近の話題"},"authors":{"en":[{"name":"Mizobuchi Yoshifumi"},{"name":"Takagi Yasushi"},{"name":"Nagahiro Shinji"}],"ja":[{"name":"溝渕 佳史"},{"name":"髙木 康志"},{"name":"永廣 信治"}]},"publication_date":"2018-10","publication_name":{"en":"Clinical Neuroscience","ja":"Clinical Neuroscience"},"volume":"Vol.36","number":"No.10","starting_page":"1128","ending_page":"1131","languages":["jpn"],"referee":true,"identifiers":{"issn":["0289-0585"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29777885","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85047768412&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341087","label":"url"}],"paper_title":{"en":"Posttraumatic Cerebrospinal Fluid Leak Associated with an Upper Cervical Meningeal Diverticulum","ja":"Posttraumatic Cerebrospinal Fluid Leak Associated with an Upper Cervical Meningeal Diverticulum"},"authors":{"en":[{"name":"Enomoto N"},{"name":"Mure Hideo"},{"name":"Okazaki Toshiyuki"},{"name":"Azumi M"},{"name":"Okita S"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"Enomoto N"},{"name":"牟礼 英生"},{"name":"岡﨑 敏之"},{"name":"Azumi M"},{"name":"Okita S"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis remains unclear. We report 2 cases of SIH resulting from CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who experienced orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1-2 level. He underwent epidural blood patch therapy, but it was unsuccessful. Next, we performed direct surgery and found a meningeal diverticulum originating from the left C2 nerve root; therefore, we ligated the diverticulum. His symptoms and image findings strikingly improved after surgery. The second case is that of a 45-year-old man who experienced orthostatic headache 1 month after jumping into a river. Magnetic resonance imaging of the head showed bilateral subdural hematoma. CT myelography revealed CSF leaks at the C1-2 level and multiple cyst formations at the cervical and thoracic nerve root sleeves. epidural blood patch was performed, and his symptoms immediately improved. Recent studies have reported that meningeal diverticulum is involved in various cases of CSF leaks. The 2 cases indicate that traumatic accidents, such as back-and-forth neck movement or falls, presumably induce an increase in CSF pressure, followed by the rupture of an existing meningeal diverticulum, leading to CSF leak.","ja":"Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis remains unclear. We report 2 cases of SIH resulting from CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who experienced orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1-2 level. He underwent epidural blood patch therapy, but it was unsuccessful. Next, we performed direct surgery and found a meningeal diverticulum originating from the left C2 nerve root; therefore, we ligated the diverticulum. His symptoms and image findings strikingly improved after surgery. The second case is that of a 45-year-old man who experienced orthostatic headache 1 month after jumping into a river. Magnetic resonance imaging of the head showed bilateral subdural hematoma. CT myelography revealed CSF leaks at the C1-2 level and multiple cyst formations at the cervical and thoracic nerve root sleeves. epidural blood patch was performed, and his symptoms immediately improved. Recent studies have reported that meningeal diverticulum is involved in various cases of CSF leaks. The 2 cases indicate that traumatic accidents, such as back-and-forth neck movement or falls, presumably induce an increase in CSF pressure, followed by the rupture of an existing meningeal diverticulum, leading to CSF leak."},"publication_date":"2018-08","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.116","starting_page":"50","ending_page":"55","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2018.05.061"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=348777","label":"url"}],"paper_title":{"en":"スポーツ頭部外傷の基礎知識","ja":"スポーツ頭部外傷の基礎知識"},"authors":{"en":[{"name":"Korai Masaaki"},{"name":"Mizobuchi Yoshifumi"},{"name":"Takagi Yasushi"},{"name":"Nagahiro Shinji"}],"ja":[{"name":"高麗 雅章"},{"name":"溝渕 佳史"},{"name":"髙木 康志"},{"name":"永廣 信治"}]},"publication_date":"2018-07","publication_name":{"en":"The Japanese Journal of Occupational Therapy","ja":"作業療法ジャーナル"},"volume":"Vol.52","number":"No.7","starting_page":"646","ending_page":"650","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.11477/mf.5001201344"],"issn":["0915-1354"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=348776","label":"url"}],"paper_title":{"en":"硬膜動静脈瘻に対する直達術","ja":"硬膜動静脈瘻に対する直達術"},"authors":{"en":[{"name":"Korai Masaaki"},{"name":"Satomi Junichiro"},{"name":"Takagi Yasushi"}],"ja":[{"name":"高麗 雅章"},{"name":"里見 淳一郎"},{"name":"髙木 康志"}]},"publication_date":"2018-07","publication_name":{"en":"Practical Currently","ja":"脳神経外科速報"},"volume":"Vol.28","number":"No.7","starting_page":"678","ending_page":"683","languages":["jpn"],"referee":true,"identifiers":{"issn":["0917-1495"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29998934","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85051865821&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=344979","label":"url"}],"paper_title":{"en":"Flow Alteration Therapy for Ruptured Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery","ja":"Flow Alteration Therapy for Ruptured Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery"},"authors":{"en":[{"name":"Kanematsu Yasuhisa"},{"name":"Satomi Junichiro"},{"name":"Korai Masaaki"},{"name":"Okazaki Toshiyuki"},{"name":"Yamaguchi Idumi"},{"name":"Tada Yoshiteru"},{"name":"Uno Masaaki"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"兼松 康久"},{"name":"里見 淳一郎"},{"name":"高麗 雅章"},{"name":"岡﨑 敏之"},{"name":"山口 泉"},{"name":"多田 恵曜"},{"name":"宇野 昌明"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"Surgery for- and endovascular treatment of vertebral artery (VA) dissecting aneurysms involving the origin of the posterior inferior cerebellar artery (PICA) remain challenging. Their ideal treatment is complete isolation of the aneurysm by surgical or endovascular trapping plus PICA reconstruction. However, postoperative lower cranial nerve palsy and medullary infarction are potential complications. We report four patients with VA dissecting aneurysms involving the PICA origin who were treated by occipital artery (OA)-PICA bypass followed by proximal occlusion of the VA and clip ligation of the PICA origin instead of trapping. There were no procedural or ischemic complications. In all patients, angiography performed 2-3 weeks later showed good patency of the bypass graft and complete obliteration of the aneurysm. During the follow-up period ranging from 1 to 14 years, none experienced bleeding. Although retrograde blood flow to the dissecting aneurysm persisted in the absence of trapping, iatrogenic lower cranial nerve injury could be avoided. The decrease in aneurysmal flow might elicit spontaneous thrombosis and prevent aneurysmal rerupture. Our technique might be less invasive than aneurysmal trapping and help to prevent rebleeding.","ja":"Surgery for- and endovascular treatment of vertebral artery (VA) dissecting aneurysms involving the origin of the posterior inferior cerebellar artery (PICA) remain challenging. Their ideal treatment is complete isolation of the aneurysm by surgical or endovascular trapping plus PICA reconstruction. However, postoperative lower cranial nerve palsy and medullary infarction are potential complications. We report four patients with VA dissecting aneurysms involving the PICA origin who were treated by occipital artery (OA)-PICA bypass followed by proximal occlusion of the VA and clip ligation of the PICA origin instead of trapping. There were no procedural or ischemic complications. In all patients, angiography performed 2-3 weeks later showed good patency of the bypass graft and complete obliteration of the aneurysm. During the follow-up period ranging from 1 to 14 years, none experienced bleeding. Although retrograde blood flow to the dissecting aneurysm persisted in the absence of trapping, iatrogenic lower cranial nerve injury could be avoided. The decrease in aneurysmal flow might elicit spontaneous thrombosis and prevent aneurysmal rerupture. Our technique might be less invasive than aneurysmal trapping and help to prevent rebleeding."},"publication_date":"2018-06","publication_name":{"en":"Neurologia Medico-Chirurgica","ja":"Neurologia Medico-Chirurgica"},"volume":"Vol.58","starting_page":"341","ending_page":"349","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2176/nmc.oa.2018-0076"],"issn":["1349-8029"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112895","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29779087","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85047143200&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341089","label":"url"}],"paper_title":{"en":"Down-regulation of MDR1 by Ad-DKK3 via Akt/NFB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model","ja":"Down-regulation of MDR1 by Ad-DKK3 via Akt/NFB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model"},"authors":{"en":[{"name":"Fujihara Toshitaka"},{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Kageji Teruyoshi"},{"name":"Matsuzaki Kazuhito"},{"name":"Kitazato KT"},{"name":"Otsuka Ryotaro"},{"name":"Hara Keijiro"},{"name":"Mure Hideo"},{"name":"Okazaki Toshiyuki"},{"name":"Kuwayama Kazuyuki"},{"name":"Nagahiro Shinji"},{"name":"Takagi Yasushi"}],"ja":[{"name":"藤原 敏孝"},{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"影治 照喜"},{"name":"松﨑 和仁"},{"name":"Kitazato KT"},{"name":"大塚 亮太朗"},{"name":"原 慶次郎"},{"name":"牟礼 英生"},{"name":"岡﨑 敏之"},{"name":"桑山 一行"},{"name":"永廣 信治"},{"name":"髙木 康志"}]},"description":{"en":"Glioblastoma multiforme (GBM) is the most malignant of brain tumors. Acquired drug resistance is a major obstacle for successful treatment. Earlier studies reported that expression of the multiple drug resistance gene (MDR1) is regulated by YB-1 or NFκB via the JNK/c-Jun or Akt pathway. Over-expression of the Dickkopf (DKK) family member DKK3 by an adenovirus vector carrying DKK3 (Ad-DKK3) exerted anti-tumor effects and led to the activation of the JNK/c-Jun pathway. We investigated whether Ad-DKK3 augments the anti-tumor effect of temozolomide (TMZ) via the regulation of MDR1. GBM cells (U87MG and U251MG), primary TGB105 cells, and mice xenografted with U87MG cells were treated with Ad-DKK3 or TMZ alone or in combination. Ad-DKK3 augmentation of the anti-tumor effects of TMZ was associated with reduced MDR1 expression in both in vivo and in vitro studies. The survival of Ad-DKK3-treated U87MG cells was inhibited and the expression of MDR1 was reduced. This was associated with the inhibition of Akt/NFκB but not of YB-1 via the JNK/c-Jun- or Akt pathway. Our results suggest that Ad-DKK3 regulates the expression of MDR1 via Akt/NFκB pathways and that it augments the anti-tumor effects of TMZ in GBM cells.","ja":"Glioblastoma multiforme (GBM) is the most malignant of brain tumors. Acquired drug resistance is a major obstacle for successful treatment. Earlier studies reported that expression of the multiple drug resistance gene (MDR1) is regulated by YB-1 or NFκB via the JNK/c-Jun or Akt pathway. Over-expression of the Dickkopf (DKK) family member DKK3 by an adenovirus vector carrying DKK3 (Ad-DKK3) exerted anti-tumor effects and led to the activation of the JNK/c-Jun pathway. We investigated whether Ad-DKK3 augments the anti-tumor effect of temozolomide (TMZ) via the regulation of MDR1. GBM cells (U87MG and U251MG), primary TGB105 cells, and mice xenografted with U87MG cells were treated with Ad-DKK3 or TMZ alone or in combination. Ad-DKK3 augmentation of the anti-tumor effects of TMZ was associated with reduced MDR1 expression in both in vivo and in vitro studies. The survival of Ad-DKK3-treated U87MG cells was inhibited and the expression of MDR1 was reduced. This was associated with the inhibition of Akt/NFκB but not of YB-1 via the JNK/c-Jun- or Akt pathway. Our results suggest that Ad-DKK3 regulates the expression of MDR1 via Akt/NFκB pathways and that it augments the anti-tumor effects of TMZ in GBM cells."},"publication_date":"2018-05-19","publication_name":{"en":"Journal of Neuro-Oncology","ja":"Journal of Neuro-Oncology"},"volume":"Vol.139","number":"No.2","starting_page":"323","ending_page":"332","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s11060-018-2894-5"],"issn":["1573-7373"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29888029","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=354179","label":"url"}],"paper_title":{"en":"Dural arteriovenous fistula in the superior orbital fissure","ja":"Dural arteriovenous fistula in the superior orbital fissure"},"authors":{"en":[{"name":"Yamamoto Yuki"},{"name":"Yamamoto Nobuaki"},{"name":"Satomi Junichiro"},{"name":"Yamaguchi Idumi"},{"name":"Korai Masaaki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Kaji Ryuji"}],"ja":[{"name":"山本 雄貴"},{"name":"山本 伸昭"},{"name":"里見 淳一郎"},{"name":"山口 泉"},{"name":"高麗 雅章"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"梶 龍兒"}]},"description":{"en":"Dural arteriovenous fistulas (dAVFs) are extremely rare in the superior orbital fissure, and they exhibit ocular symptoms similar to the dAVF in the cavernous sinus because of the intraorbital venous congestion. Hence, the distinction of these conditions is imperative because of some inherent differences in endovascular treatment techniques. A 58-year-old woman presented with a gradually worsening left eyeball protrusion and conjunctival congestion. The digital subtraction angiography revealed a dAVF with a shunting point in the left superior orbital fissure. Moreover, the inferolateral trunk of the left internal carotid artery and the left middle meningeal artery were involved as feeding arteries. Shunting blood flow drained into the facial vein through the superior ophthalmic vein (SOV) but not into the cavernous sinus, which was located just posterior to the superior orbital fissure. We performed transvenous coil embolization in the SOV through the facial vein, and the symptoms disappeared completely. We experienced a case of a dAVF in the superior orbital fissure. This case presented a possibility of the presence of one subtype of the dAVF in the part of the cavernous sinus separated at the superior orbital fissure in front. Transvenous coil embolization in the SOV through the facial vein efficiently occluded the fistula.","ja":"Dural arteriovenous fistulas (dAVFs) are extremely rare in the superior orbital fissure, and they exhibit ocular symptoms similar to the dAVF in the cavernous sinus because of the intraorbital venous congestion. Hence, the distinction of these conditions is imperative because of some inherent differences in endovascular treatment techniques. A 58-year-old woman presented with a gradually worsening left eyeball protrusion and conjunctival congestion. The digital subtraction angiography revealed a dAVF with a shunting point in the left superior orbital fissure. Moreover, the inferolateral trunk of the left internal carotid artery and the left middle meningeal artery were involved as feeding arteries. Shunting blood flow drained into the facial vein through the superior ophthalmic vein (SOV) but not into the cavernous sinus, which was located just posterior to the superior orbital fissure. We performed transvenous coil embolization in the SOV through the facial vein, and the symptoms disappeared completely. We experienced a case of a dAVF in the superior orbital fissure. This case presented a possibility of the presence of one subtype of the dAVF in the part of the cavernous sinus separated at the superior orbital fissure in front. Transvenous coil embolization in the SOV through the facial vein efficiently occluded the fistula."},"publication_date":"2018-05-07","publication_name":{"en":"Surgical Neurology International","ja":"Surgical Neurology International"},"volume":"Vol.9","number":"No.1","starting_page":"95","ending_page":"95","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4103/sni.sni_46_18"],"issn":["2229-5097"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29110329","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85043983951&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=354187","label":"url"}],"paper_title":{"en":"Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia","ja":"Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia"},"authors":{"en":[{"name":"Helmanto Y"},{"name":"Sunohara T"},{"name":"Faried A"},{"name":"Takagi Yasushi"},{"name":"Takahashi J"},{"name":"Maki T"},{"name":"Miyamoto S"}],"ja":[{"name":"Helmanto Y"},{"name":"Sunohara T"},{"name":"Faried A"},{"name":"髙木 康志"},{"name":"Takahashi J"},{"name":"Maki T"},{"name":"宮本 亨"}]},"description":{"en":"The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation of cell therapy development requires the xeno-free condition to eliminate clinical complications. Maintenance of hiPSCs with feeder-free condition presents a higher degree of spontaneous differentiation in comparison with conventional cultures. Therefore, feeder-free derivation might be not ideal for developing transplantable hiPSC derivatives. We developed the feeder-free condition for differentiation of cortical neurons from hiPSCs. Then, we evaluated the cells' characteristics upon transplantation into the sham and focal brain ischemia on adult male Wistar rats. Grafts in lesioned brains demonstrated polarized reactivity toward the ischemic border, indicated by directional preferences in axonal outgrowth and cellular migration, with no influence on graft survival. Following the transplantation, forelimb asymmetry was better restored compared with controls. Herein, we provide evidence to support the use of the xeno-free condition for the development of cell therapy for ischemic stroke.","ja":"The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation of cell therapy development requires the xeno-free condition to eliminate clinical complications. Maintenance of hiPSCs with feeder-free condition presents a higher degree of spontaneous differentiation in comparison with conventional cultures. Therefore, feeder-free derivation might be not ideal for developing transplantable hiPSC derivatives. We developed the feeder-free condition for differentiation of cortical neurons from hiPSCs. Then, we evaluated the cells' characteristics upon transplantation into the sham and focal brain ischemia on adult male Wistar rats. Grafts in lesioned brains demonstrated polarized reactivity toward the ischemic border, indicated by directional preferences in axonal outgrowth and cellular migration, with no influence on graft survival. Following the transplantation, forelimb asymmetry was better restored compared with controls. Herein, we provide evidence to support the use of the xeno-free condition for the development of cell therapy for ischemic stroke."},"publication_date":"2018-05","publication_name":{"en":"Journal of Neuroscience Research","ja":"Journal of Neuroscience Research"},"volume":"Vol.96","number":"No.5","starting_page":"863","ending_page":"874","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/jnr.24197"],"issn":["1097-4547"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29217366","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85036626734&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=354181","label":"url"}],"paper_title":{"en":"Initially Missed or Delayed Diagnosis of Subarachnoid Hemorrhage: A Nationwide Survey of Contributing Factors and Outcomes in Japan.","ja":"Initially Missed or Delayed Diagnosis of Subarachnoid Hemorrhage: A Nationwide Survey of Contributing Factors and Outcomes in Japan."},"authors":{"en":[{"name":"Takagi Yasushi"},{"name":"Hadeishi H"},{"name":"Mineharu Y"},{"name":"Yoshida K"},{"name":"Ogasawara K"},{"name":"Ogawa A"},{"name":"Miyamamoto S"}],"ja":[{"name":"髙木 康志"},{"name":"波出石 弘"},{"name":"峰晴 陽平"},{"name":"Yoshida K"},{"name":"Ogasawara K"},{"name":"Ogawa A"},{"name":"宮本 亨"}]},"description":{"en":"Subarachnoid hemorrhage (SAH) remains a significant cause of mortality in Japan. The Japan Stroke Society set out to conduct a nationwide survey to identify contributing factors and outcomes of SAH misdiagnosis. We initially surveyed 737 training institutes and 1259 departments in Japan between April 2012 and March 2014 for the presence of misdiagnosed SAH. Clinical information was then sought from respondents with a positive misdiagnosis. Information on 579 misdiagnosed cases was collected. Most initial misdiagnoses occurred in nonteaching hospitals (72%). Of those presenting with headache, 55% did not undergo a computed tomography (CT) scan. In addition, SAH was missed in the patients who underwent CT scans. The clinically diagnosed rerupture rate was 27%. Mortality among all cases was 11%. Institutes achieving a final diagnosis were staffed by neurologists or neurosurgeons. Multivariate logistic regression analysis indicated that age (≥65), consciousness level (Japan Coma Scale score at correct diagnosis), rerupture of an aneurysm, and no treatment by clipping or coiling were significantly associated with poor clinical outcome. The prognosis of misdiagnosis of SAH is severe. Neuroradiological assessment and correct diagnosis can prevent SAH misdiagnosis. When there is a possible diagnosis of SAH, consultation with a specialist is important.","ja":"Subarachnoid hemorrhage (SAH) remains a significant cause of mortality in Japan. The Japan Stroke Society set out to conduct a nationwide survey to identify contributing factors and outcomes of SAH misdiagnosis. We initially surveyed 737 training institutes and 1259 departments in Japan between April 2012 and March 2014 for the presence of misdiagnosed SAH. Clinical information was then sought from respondents with a positive misdiagnosis. Information on 579 misdiagnosed cases was collected. Most initial misdiagnoses occurred in nonteaching hospitals (72%). Of those presenting with headache, 55% did not undergo a computed tomography (CT) scan. In addition, SAH was missed in the patients who underwent CT scans. The clinically diagnosed rerupture rate was 27%. Mortality among all cases was 11%. Institutes achieving a final diagnosis were staffed by neurologists or neurosurgeons. Multivariate logistic regression analysis indicated that age (≥65), consciousness level (Japan Coma Scale score at correct diagnosis), rerupture of an aneurysm, and no treatment by clipping or coiling were significantly associated with poor clinical outcome. The prognosis of misdiagnosis of SAH is severe. Neuroradiological assessment and correct diagnosis can prevent SAH misdiagnosis. When there is a possible diagnosis of SAH, consultation with a specialist is important."},"publication_date":"2018-04","publication_name":{"en":"Journal of Stroke & Cerebrovascular Diseases","ja":"Journal of Stroke & Cerebrovascular Diseases"},"volume":"Vol.27","number":"No.4","starting_page":"871","ending_page":"877","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jstrokecerebrovasdis.2017.10.024"],"issn":["1532-8511"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112440","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29483617","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85042728382&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341080","label":"url"}],"paper_title":{"en":"Dysregulation of RNF213 promotes cerebral hypoperfusion.","ja":"Dysregulation of RNF213 promotes cerebral hypoperfusion."},"authors":{"en":[{"name":"Morimoto Takaaki"},{"name":"Enmi Jun-ichiro"},{"name":"Hattori Yorito"},{"name":"Iguchi Satoshi"},{"name":"Saito Satoshi"},{"name":"Harada H. Kouji"},{"name":"Okuda Hiroko"},{"name":"Mineharu Yohei"},{"name":"Takagi Yasushi"},{"name":"Youssefian Shohab"},{"name":"Iida Hidehiro"},{"name":"Miyamoto Susumu"},{"name":"Ihara Masafumi"},{"name":"Kobayashi Hatasu"},{"name":"Koizumi Akio"}],"ja":[{"name":"Morimoto Takaaki"},{"name":"Enmi Jun-ichiro"},{"name":"Hattori Yorito"},{"name":"Iguchi Satoshi"},{"name":"Saito Satoshi"},{"name":"Harada H. Kouji"},{"name":"Okuda Hiroko"},{"name":"Mineharu Yohei"},{"name":"髙木 康志"},{"name":"Youssefian Shohab"},{"name":"Iida Hidehiro"},{"name":"Miyamoto Susumu"},{"name":"Ihara Masafumi"},{"name":"Kobayashi Hatasu"},{"name":"Koizumi Akio"}]},"description":{"en":"RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are indicative of the essential role of RNF213 in the maintenance of CBF.","ja":"RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are indicative of the essential role of RNF213 in the maintenance of CBF."},"publication_date":"2018-02-26","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.8","number":"No.1","starting_page":"3607","ending_page":"3607","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-018-22064-8"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://ci.nii.ac.jp/naid/40021806130/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1520572358412476800/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=349015","label":"url"}],"paper_title":{"en":"Multi-disciplinary approach for dystonia patients by treatment with deep brain stimulation","ja":"ジストニアDBS治療における多職種連携"},"authors":{"en":[{"name":"Mure Hideo"},{"name":"Morigaki Ryoma"},{"name":"Miyamoto Ryosuke"},{"name":"Nakataki Masahito"},{"name":"岡久 哲也"},{"name":"Katoh Shinsuke"},{"name":"Kaji Ryuji"},{"name":"Takagi Yasushi"},{"name":"Nagahiro Shinji"},{"name":"Goto Satoshi"}],"ja":[{"name":"牟礼 英生"},{"name":"森垣 龍馬"},{"name":"宮本 亮介"},{"name":"中瀧 理仁"},{"name":"岡久 哲也"},{"name":"加藤 真介"},{"name":"梶 龍兒"},{"name":"髙木 康志"},{"name":"永廣 信治"},{"name":"後藤 惠"}]},"publication_date":"2018","publication_name":{"en":"Functional Neurosurgery","ja":"機能的脳神経外科"},"volume":"Vol.57","starting_page":"35","ending_page":"39","languages":["jpn"],"referee":true,"identifiers":{"issn":["1344-9699"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28826708","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85028297766&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341081","label":"url"}],"paper_title":{"en":"Occlusion Status on Magnetic Resonance Angiography Is Associated with Risk of Delayed Ischemic Events in Cerebral Aneurysms Treated with Stent-Assisted Coiling.","ja":"Occlusion Status on Magnetic Resonance Angiography Is Associated with Risk of Delayed Ischemic Events in Cerebral Aneurysms Treated with Stent-Assisted Coiling."},"authors":{"en":[{"name":"Kikuchi Takayuki"},{"name":"Ishii Akira"},{"name":"Chihara Hideo"},{"name":"Arai Daisuke"},{"name":"Ando Mitsushige"},{"name":"Takenobu Yohei"},{"name":"Okada Tomohisa"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Kikuchi Takayuki"},{"name":"Ishii Akira"},{"name":"Chihara Hideo"},{"name":"Arai Daisuke"},{"name":"Ando Mitsushige"},{"name":"Takenobu Yohei"},{"name":"Okada Tomohisa"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"}]},"description":{"en":"Management after stent-assisted coiling (SAC) for unruptured intracranial aneurysm is sometimes difficult because close monitoring for ischemic events for a long period of time after the procedure is necessary. The purpose of this study was to clarify the usefulness of magnetic resonance angiography (MRA) at follow-up after SAC. Sixty-six consecutive cases of SAC for unruptured intracranial aneurysm in our institute and affiliated hospitals were retrospectively reviewed for a delayed ischemic event. Occlusion status of the aneurysm and stent apposition on time-of-flight (TOF)-MRA, patient demographics, and characteristics of the aneurysms were analyzed for a possible relationship to delayed ischemic events. Over a median follow-up of 755 days, 14 patients had delayed ischemic events after a median follow-up of 230.5 days. All of the ischemic events were transient or asymptomatic. Univariate analysis revealed that the history of hypertension (P = 0.042) and the occlusion status of the aneurysm (P = 0.006) were significantly associated with delayed ischemic events. Multivariate analysis indicated that dome filling had a hazard ratio of 4.96 (95% confidence interval [CI], 1.30-23.60) and 3.74 (95% CI, 1.10-13.34), compared with neck remnant and complete obliteration, respectively. Six of 7 patients who had persistent dome filling during follow-up developed a delayed ischemic event. In this preliminary study, dome filling on follow-up TOF-MRA is a possible risk factor for delayed ischemic events. TOF-MRA could be a modality for tailored management after SAC.","ja":"Management after stent-assisted coiling (SAC) for unruptured intracranial aneurysm is sometimes difficult because close monitoring for ischemic events for a long period of time after the procedure is necessary. The purpose of this study was to clarify the usefulness of magnetic resonance angiography (MRA) at follow-up after SAC. Sixty-six consecutive cases of SAC for unruptured intracranial aneurysm in our institute and affiliated hospitals were retrospectively reviewed for a delayed ischemic event. Occlusion status of the aneurysm and stent apposition on time-of-flight (TOF)-MRA, patient demographics, and characteristics of the aneurysms were analyzed for a possible relationship to delayed ischemic events. Over a median follow-up of 755 days, 14 patients had delayed ischemic events after a median follow-up of 230.5 days. All of the ischemic events were transient or asymptomatic. Univariate analysis revealed that the history of hypertension (P = 0.042) and the occlusion status of the aneurysm (P = 0.006) were significantly associated with delayed ischemic events. Multivariate analysis indicated that dome filling had a hazard ratio of 4.96 (95% confidence interval [CI], 1.30-23.60) and 3.74 (95% CI, 1.10-13.34), compared with neck remnant and complete obliteration, respectively. Six of 7 patients who had persistent dome filling during follow-up developed a delayed ischemic event. In this preliminary study, dome filling on follow-up TOF-MRA is a possible risk factor for delayed ischemic events. TOF-MRA could be a modality for tailored management after SAC."},"publication_date":"2017-11","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.107","starting_page":"226","ending_page":"232","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2017.07.161"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28497183","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85018662847&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341083","label":"url"}],"paper_title":{"en":"Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia.","ja":"Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia."},"authors":{"en":[{"name":"Araki Yoshio"},{"name":"Takagi Yasushi"},{"name":"Mineharu Yohei"},{"name":"Kobayashi Hatasu"},{"name":"Miyamoto Susumu"},{"name":"Wakabayashi Toshihiko"}],"ja":[{"name":"Araki Yoshio"},{"name":"髙木 康志"},{"name":"Mineharu Yohei"},{"name":"Kobayashi Hatasu"},{"name":"Miyamoto Susumu"},{"name":"Wakabayashi Toshihiko"}]},"description":{"en":"Focal cerebral arteriopathy includes unifocal or multifocal lesions that are unilateral or bilateral. Large- and/or medium-sized vessels are involved and can be visualized on angiography. We report a case of cerebral infarction in a 9-year-old Japanese female who presented with a transient ischemic attack. Steno-occlusion involving the distal part of the internal carotid artery, proximal middle cerebral artery, and anterior cerebral artery was observed. Digital subtraction angiography demonstrated a beaded appearance in the cervical portion of the diseased internal carotid artery. Revascularization surgery was performed 45 days after the onset. A new infarction appeared on the other side of the anterior cerebral artery territory 7 months after the first onset. Antiplatelets and vasodilators were administered, and no progression was observed during 18 months of follow-up. Genetic analysis did not show ring finger protein 213 (RNF213)-related moyamoya disease, and pathological examination revealed no characteristics of fibromuscular dysplasia. The radiological and genetic features coincided with focal cerebral arteriopathy, which is a distinct entity from fibromuscular dysplasia and RNF213-related moyamoya disease.","ja":"Focal cerebral arteriopathy includes unifocal or multifocal lesions that are unilateral or bilateral. Large- and/or medium-sized vessels are involved and can be visualized on angiography. We report a case of cerebral infarction in a 9-year-old Japanese female who presented with a transient ischemic attack. Steno-occlusion involving the distal part of the internal carotid artery, proximal middle cerebral artery, and anterior cerebral artery was observed. Digital subtraction angiography demonstrated a beaded appearance in the cervical portion of the diseased internal carotid artery. Revascularization surgery was performed 45 days after the onset. A new infarction appeared on the other side of the anterior cerebral artery territory 7 months after the first onset. Antiplatelets and vasodilators were administered, and no progression was observed during 18 months of follow-up. Genetic analysis did not show ring finger protein 213 (RNF213)-related moyamoya disease, and pathological examination revealed no characteristics of fibromuscular dysplasia. The radiological and genetic features coincided with focal cerebral arteriopathy, which is a distinct entity from fibromuscular dysplasia and RNF213-related moyamoya disease."},"publication_date":"2017-08","publication_name":{"en":"Child's Nervous System","ja":"Child's Nervous System"},"volume":"Vol.33","number":"No.8","starting_page":"1405","ending_page":"1409","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00381-017-3451-9"],"issn":["1433-0350"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28506590","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85019147342&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341082","label":"url"}],"paper_title":{"en":"RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.","ja":"RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease."},"authors":{"en":[{"name":"Matsuda Yoshiko"},{"name":"Mineharu Yohei"},{"name":"Kimura Mitsuru"},{"name":"Takagi Yasushi"},{"name":"Kobayashi Hatasu"},{"name":"Hitomi Toshiaki"},{"name":"Harada H. Kouji"},{"name":"Uchihashi Yoshito"},{"name":"Funaki Takeshi"},{"name":"Miyamoto Susumu"},{"name":"Koizumi Akio"}],"ja":[{"name":"Matsuda Yoshiko"},{"name":"Mineharu Yohei"},{"name":"Kimura Mitsuru"},{"name":"髙木 康志"},{"name":"Kobayashi Hatasu"},{"name":"Hitomi Toshiaki"},{"name":"Harada H. Kouji"},{"name":"Uchihashi Yoshito"},{"name":"Funaki Takeshi"},{"name":"Miyamoto Susumu"},{"name":"Koizumi Akio"}]},"description":{"en":"This study aimed to determine the effectiveness of genetic testing for the p.R4810K variant (rs112735431) of the Mysterin/RNF213 gene, which is associated with moyamoya disease and other intracranial vascular diseases, in the family members of patients with moyamoya disease. We performed genotyping of the RNF213 p.R4810K polymorphism and magnetic resonance angiography on 59 relatives of 18 index patients with moyamoya disease. Nineteen individuals had follow-up magnetic resonance angiography with a mean follow-up period of 7.2 years. Six of the 34 individuals with the GA genotype (heterozygotes for p.R4810K) showed intracranial steno-occlusive lesions in the magnetic resonance angiography, whereas none of the 25 individuals with the GG genotype (wild type) showed any abnormalities. Follow-up magnetic resonance angiography revealed de novo lesions in 2 and disease progression in 1 of the 11 individuals with the GA genotype, despite none of the 8 individuals with the GG genotype showing any changes. Accordingly, 8 individuals had steno-occlusive lesions at the last follow-up, and all had the p.R4810K risk variant. The prevalence of steno-occlusive intracranial arterial diseases in family members with the p.R4810K variant was 23.5% (95% confidence interval: 9.27%-37.78%), which was significantly higher than in those without the variant (0%, P = .0160). Genotyping of the p.R4810K missense variant is useful for identifying individuals with an elevated risk for steno-occlusive intracranial arterial diseases in the family members of patients with moyamoya disease.","ja":"This study aimed to determine the effectiveness of genetic testing for the p.R4810K variant (rs112735431) of the Mysterin/RNF213 gene, which is associated with moyamoya disease and other intracranial vascular diseases, in the family members of patients with moyamoya disease. We performed genotyping of the RNF213 p.R4810K polymorphism and magnetic resonance angiography on 59 relatives of 18 index patients with moyamoya disease. Nineteen individuals had follow-up magnetic resonance angiography with a mean follow-up period of 7.2 years. Six of the 34 individuals with the GA genotype (heterozygotes for p.R4810K) showed intracranial steno-occlusive lesions in the magnetic resonance angiography, whereas none of the 25 individuals with the GG genotype (wild type) showed any abnormalities. Follow-up magnetic resonance angiography revealed de novo lesions in 2 and disease progression in 1 of the 11 individuals with the GA genotype, despite none of the 8 individuals with the GG genotype showing any changes. Accordingly, 8 individuals had steno-occlusive lesions at the last follow-up, and all had the p.R4810K risk variant. The prevalence of steno-occlusive intracranial arterial diseases in family members with the p.R4810K variant was 23.5% (95% confidence interval: 9.27%-37.78%), which was significantly higher than in those without the variant (0%, P = .0160). Genotyping of the p.R4810K missense variant is useful for identifying individuals with an elevated risk for steno-occlusive intracranial arterial diseases in the family members of patients with moyamoya disease."},"publication_date":"2017-08","publication_name":{"en":"Journal of Stroke & Cerebrovascular Diseases","ja":"Journal of Stroke & Cerebrovascular Diseases"},"volume":"Vol.26","number":"No.8","starting_page":"1841","ending_page":"1847","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jstrokecerebrovasdis.2017.04.019"],"issn":["1532-8511"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112364","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28414759","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85017628389&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341935","label":"url"}],"paper_title":{"en":"Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.","ja":"Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease."},"authors":{"en":[{"name":"Morimoto Takaaki"},{"name":"Mineharu Yohei"},{"name":"Ono Koh"},{"name":"Nakatochi Masahiro"},{"name":"Ichihara Sahoko"},{"name":"Kabata Risako"},{"name":"Takagi Yasushi"},{"name":"Cao Yang"},{"name":"Zhao Lanying"},{"name":"Kobayashi Hatasu"},{"name":"Harada H. Kouji"},{"name":"Takenaka Katsunobu"},{"name":"Funaki Takeshi"},{"name":"Yokota Mitsuhiro"},{"name":"Matsubara Tatsuaki"},{"name":"Yamamoto Ken"},{"name":"Izawa Hideo"},{"name":"Kimura Takeshi"},{"name":"Miyamoto Susumu"},{"name":"Koizumi Akio"}],"ja":[{"name":"Morimoto Takaaki"},{"name":"Mineharu Yohei"},{"name":"Ono Koh"},{"name":"Nakatochi Masahiro"},{"name":"Ichihara Sahoko"},{"name":"Kabata Risako"},{"name":"髙木 康志"},{"name":"Cao Yang"},{"name":"Zhao Lanying"},{"name":"Kobayashi Hatasu"},{"name":"Harada H. Kouji"},{"name":"Takenaka Katsunobu"},{"name":"Funaki Takeshi"},{"name":"Yokota Mitsuhiro"},{"name":"Matsubara Tatsuaki"},{"name":"Yamamoto Ken"},{"name":"Izawa Hideo"},{"name":"Kimura Takeshi"},{"name":"Miyamoto Susumu"},{"name":"Koizumi Akio"}]},"description":{"en":"The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery disease; however, this possibility has never been tested. We genotyped the RNF213 p.R4810K variant in 956 coronary artery disease patients and 716 controls and tested the association between p.R4810K and coronary artery disease. We also validated the association in an independent population of 311 coronary artery disease patients and 494 controls. In the replication study, the p.R4810K genotypes were imputed from genome-wide genotyping data based on the 1000 Genomes Project. We used multivariate logistic regression analyses to adjust for well-known risk factors such as dyslipidemia and smoking habits. In the primary study population, the frequency of the minor variant allele was significantly higher in patients with coronary artery disease than in controls (2.04% vs. 0.98%), with an odds ratio of 2.11 (p = 0.017). Under a dominant model, after adjustment for risk factors, the association remained significant, with an odds ratio of 2.90 (95% confidence interval: 1.37-6.61; p = 0.005). In the replication study, the association was significant after adjustment for age and sex (odds ratio = 4.99; 95% confidence interval: 1.16-21.53; p = 0.031), although it did not reach statistical significance when further adjusted for risk factors (odds ratio = 3.82; 95% confidence interval: 0.87-16.77; p = 0.076). The RNF213 p.R4810K variant appears to be significantly associated with coronary artery disease in the Japanese population.","ja":"The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery disease; however, this possibility has never been tested. We genotyped the RNF213 p.R4810K variant in 956 coronary artery disease patients and 716 controls and tested the association between p.R4810K and coronary artery disease. We also validated the association in an independent population of 311 coronary artery disease patients and 494 controls. In the replication study, the p.R4810K genotypes were imputed from genome-wide genotyping data based on the 1000 Genomes Project. We used multivariate logistic regression analyses to adjust for well-known risk factors such as dyslipidemia and smoking habits. In the primary study population, the frequency of the minor variant allele was significantly higher in patients with coronary artery disease than in controls (2.04% vs. 0.98%), with an odds ratio of 2.11 (p = 0.017). Under a dominant model, after adjustment for risk factors, the association remained significant, with an odds ratio of 2.90 (95% confidence interval: 1.37-6.61; p = 0.005). In the replication study, the association was significant after adjustment for age and sex (odds ratio = 4.99; 95% confidence interval: 1.16-21.53; p = 0.031), although it did not reach statistical significance when further adjusted for risk factors (odds ratio = 3.82; 95% confidence interval: 0.87-16.77; p = 0.076). The RNF213 p.R4810K variant appears to be significantly associated with coronary artery disease in the Japanese population."},"publication_date":"2017-04-17","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.12","number":"No.4","starting_page":"e0175649","ending_page":"e0175649","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0175649"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27742510","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85005814169&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341086","label":"url"}],"paper_title":{"en":"Ruptured Aneurysms of the Occipital Artery Associated with Congenital Occipital Bone Defect.","ja":"Ruptured Aneurysms of the Occipital Artery Associated with Congenital Occipital Bone Defect."},"authors":{"en":[{"name":"Kawasaki Toshinari"},{"name":"Yoshida Kazumichi"},{"name":"Kikuchi Takayuki"},{"name":"Ishii Akira"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Kawasaki Toshinari"},{"name":"Yoshida Kazumichi"},{"name":"Kikuchi Takayuki"},{"name":"Ishii Akira"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"}]},"description":{"en":"Traumatic aneurysms of the superficial temporal artery have been frequently reported in the literature, whereas traumatic aneurysms of the occipital artery (OA) are extremely rare. A 30-year-old man had been followed at another hospital for meningoencephalocele associated with his congenital occipital bone defect. He was admitted to our hospital with a chief complaint of neck swelling and pain during a football game. Computed tomography and magnetic resonance imaging showed a hematoma in his right neck along with the meningoencephalocele. In addition, it showed an atrophic cerebellum with a cyst protruding from his occipital bone defect. Digital subtraction angiography of the right OA showed 3 aneurysms responsible for the large hematoma in his neck. Endovascular embolization with 20% N-butyl-2-cyanoacrylate was performed for treatment of the ruptured aneurysms followed by emergent surgical evacuation of the hematoma. An occipital cranioplasty with titanium mesh was performed 10 months after the emergent intervention. In this patient, the congenital occipital bone defect with meningoencephalocele might have been the remote source of risk for traumatic pseudoaneurysms along the muscle branches of the OA.","ja":"Traumatic aneurysms of the superficial temporal artery have been frequently reported in the literature, whereas traumatic aneurysms of the occipital artery (OA) are extremely rare. A 30-year-old man had been followed at another hospital for meningoencephalocele associated with his congenital occipital bone defect. He was admitted to our hospital with a chief complaint of neck swelling and pain during a football game. Computed tomography and magnetic resonance imaging showed a hematoma in his right neck along with the meningoencephalocele. In addition, it showed an atrophic cerebellum with a cyst protruding from his occipital bone defect. Digital subtraction angiography of the right OA showed 3 aneurysms responsible for the large hematoma in his neck. Endovascular embolization with 20% N-butyl-2-cyanoacrylate was performed for treatment of the ruptured aneurysms followed by emergent surgical evacuation of the hematoma. An occipital cranioplasty with titanium mesh was performed 10 months after the emergent intervention. In this patient, the congenital occipital bone defect with meningoencephalocele might have been the remote source of risk for traumatic pseudoaneurysms along the muscle branches of the OA."},"publication_date":"2017-01","publication_name":{"en":"World Neurosurgery","ja":"World Neurosurgery"},"volume":"Vol.97","starting_page":"759.e13","ending_page":"759.e15","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.wneu.2016.09.116"],"issn":["1878-8769"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27812816","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84994309547&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341085","label":"url"}],"paper_title":{"en":"Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature.","ja":"Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature."},"authors":{"en":[{"name":"Nakayama Yoichi"},{"name":"Mineharu Yohei"},{"name":"Arawaka Yoshiki"},{"name":"Nishida Sei"},{"name":"Tsuji Hirofumi"},{"name":"Miyake Hidehiko"},{"name":"Yamaguchi Maki"},{"name":"Minamiguchi Sachiko"},{"name":"Takagi Yasushi"},{"name":"Miyamoto Susumu"}],"ja":[{"name":"Nakayama Yoichi"},{"name":"Mineharu Yohei"},{"name":"Arawaka Yoshiki"},{"name":"Nishida Sei"},{"name":"Tsuji Hirofumi"},{"name":"Miyake Hidehiko"},{"name":"Yamaguchi Maki"},{"name":"Minamiguchi Sachiko"},{"name":"髙木 康志"},{"name":"Miyamoto Susumu"}]},"description":{"en":"Cerebral amyloid angiopathy (CAA), a cause of recurrent and multiple lobar hemorrhages, characteristically occurs in persons aged ≥55 years. We report a case of a 32-year-old male who had recurrent hemorrhage in the left multiple lobes, with a history of traumatic brain injury and hematoma evacuation at the age of 1 year. He underwent surgical treatment and was histopathologically diagnosed as having CAA. The literature review yielded six CAA cases, including ours, aged less than 55 years. All were male and four had histories of severe TBI, suggesting that male sex and TBI may be associated with CAA in young persons.","ja":"Cerebral amyloid angiopathy (CAA), a cause of recurrent and multiple lobar hemorrhages, characteristically occurs in persons aged ≥55 years. We report a case of a 32-year-old male who had recurrent hemorrhage in the left multiple lobes, with a history of traumatic brain injury and hematoma evacuation at the age of 1 year. He underwent surgical treatment and was histopathologically diagnosed as having CAA. The literature review yielded six CAA cases, including ours, aged less than 55 years. All were male and four had histories of severe TBI, suggesting that male sex and TBI may be associated with CAA in young persons."},"publication_date":"2017-01","publication_name":{"en":"Acta Neurochirurgica","ja":"Acta Neurochirurgica"},"volume":"Vol.159","number":"No.1","starting_page":"15","ending_page":"18","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00701-016-3004-0"],"issn":["0942-0940"]},"published_paper_type":"scientific_journal"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37345942","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85168222953&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=398277","label":"url"}],"paper_title":{"en":"Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series","ja":"Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series"},"authors":{"en":[{"name":"Yamaguchi Izumi"},{"name":"Kanematsu Yasuhisa"},{"name":"Shimada Kenji"},{"name":"Yamamoto Nobuaki"},{"name":"Korai Masaaki"},{"name":"Miyake Kazuhisa"},{"name":"Miyamoto Takeshi"},{"name":"Sogabe Shu"},{"name":"Shikata Eiji"},{"name":"Ishihara Manabu"},{"name":"Yamamoto Yuki"},{"name":"KURODA Kazutaka"},{"name":"Takagi Yasushi"}],"ja":[{"name":"山口 泉"},{"name":"兼松 康久"},{"name":"島田 健司"},{"name":"山本 伸昭"},{"name":"高麗 雅章"},{"name":"三宅 一央"},{"name":"宮本 健志"},{"name":"曽我部 周"},{"name":"四方 英二"},{"name":"石原 学"},{"name":"山本 雄貴"},{"name":"黒田 一駿"},{"name":"髙木 康志"}]},"description":{"en":"Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery.","ja":"Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery."},"publication_date":"2023-06-22","publication_name":{"en":"Operative Neurosurgery","ja":"Operative Neurosurgery"},"volume":"Vol.25","number":"No.3","starting_page":"292","ending_page":"300","languages":["eng"],"identifiers":{"doi":["10.1227/ons.0000000000000796"],"issn":["2332-4260"]},"published_paper_type":"research_institution"}} {"insert":{"type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385703","label":"url"}],"paper_title":{"en":"Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics","ja":"Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics"},"authors":{"en":[{"name":"Matsumoto Yuki"},{"name":"Kanazawa Yuki"},{"name":"Kinjo Yuki"},{"name":"Harada Masafumi"},{"name":"Miyati Toshiaki"},{"name":"Hayashi Hiroaki"},{"name":"Miyoshi Mitsuharu"},{"name":"Maeda Naoki"},{"name":"Kanematsu Yasuhisa"},{"name":"Takagi Yasushi"},{"name":"Haga Akihiro"}],"ja":[{"name":"松元 友暉"},{"name":"金澤 裕樹"},{"name":"金城 佑奎"},{"name":"原田 雅史"},{"name":"Miyati Toshiaki"},{"name":"林 裕晃"},{"name":"Miyoshi Mitsuharu"},{"name":"前田 直輝"},{"name":"兼松 康久"},{"name":"髙木 康志"},{"name":"芳賀 昭弘"}]},"publication_date":"2022-05-11","publication_name":{"en":"Proceedings of the 2022 ISMRM & SMRT ANNUAL MEETING & EXHIBITION, No.3783, 2022","ja":"Proceedings of the 2022 ISMRM & SMRT ANNUAL MEETING & EXHIBITION, No.3783, 2022"},"languages":["eng"],"published_paper_type":"research_institution"}}