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徳島大学 > 研究クラスター群 > 研究クラスター群 (登録) > 1804006 薬理学的見地に基づく徳島大学発革新的治療薬の創出-医療ビッグデータを活用したドラッグリポジショニング研究- >
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研究活動

専門分野

研究テーマ

著書・論文

著書:

1. 岡田 直人, 中馬 真幸, 座間味 義人, 石澤 啓介 :
考え方がわかれば解き方がみえてくる クリニカルクエスチョンの解決 への道筋,
月刊薬事, 2018年.

学術論文(審査論文):

1. Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, R Mitsunobu Kano and Keisuke Ishizawa :
Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database.,
Frontiers in pharmacology, Vol.10, 2019.
(DOI: 10.3389/fphar.2019.01257,   PubMed: 31780928)
2. Hirofumi Hamano, Takahiro Niimua, Yuya Horinouchi, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Masaki Imanishi, Masayuki Chuma, Yuki Izawa-Ishizawa, Licht Miyamoto, Keijo Fukushima, Hiromichi Fujino, Koichiro Tsuchiya, Keisuke Ishizawa, Toshiaki Tamaki and Yasumasa Ikeda :
Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway,
Toxicology Letters, Vol.318, 86-91, 2019.
(徳島大学機関リポジトリ: 113812,   DOI: 10.1016/j.toxlet.2019.10.016,   PubMed: 31669099)
3. Naoto Okada, Masayuki Chuma, Momoyo Azuma, Shingen Nakamura, Hirokazu Miki, Hirofumi Hamano, Mitsuhiro Goda, Kenshi Takechi, Yoshito Zamami, Masahiro Abe and Keisuke Ishizawa :
Effect of serum concentration and concomitant drugs on vancomycin-induced acute kidney injury in haematologic patients: a single-centre retrospective study.,
European Journal of Clinical Pharmacology, Vol.75, No.12, 1695-1704, 2019.
(DOI: 10.1007/s00228-019-02756-4,   PubMed: 31511938)
4. Takumi Sakurada, Sanako Bando, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Mitsuhiro Goda, Yasushi Kirino, Toshimi Nakamura, Kazuhiko Teraoka, Masami Morimoto, Akira Tangoku and Keisuke Ishizawa :
Prophylactic administration of granulocyte colony-stimulating factor in epirubicin and cyclophosphamide chemotherapy for Japanese breast cancer patients: a retrospective study.,
Cancer Chemotherapy and Pharmacology, Vol.84, No.5, 1107-1114, 2019.
(DOI: 10.1007/s00280-019-03948-6,   PubMed: 31502114)
5. Takahiro Nakayama, Masayuki Chuma, Naohiro Tochikura, So Iwabuchi, Shinichiro Suzuki, Chiaki Matsumoto, Toru Imai, Takashi Hamada, Masaru Nakagawa, Hiromichi Takahashi, Yoshihito Uchino, Katsuhiro Miura, Noriyoshi Iriyama, Yoshihiro Hatta, Masami Takei and Takahisa Kimura :
Increased arbekacin clearance in patients with febrile neutropenia.,
Therapeutic Drug Monitoring, 2019.
(DOI: 10.1097/FTD.0000000000000678,   PubMed: 31323015)
6. Hirofumi Hamano, Marin Mitsui, Yoshito Zamami, Kenshi Takechi, Takahiro Nimura, Naoto Okada, Keijo Fukushima, Masaki Imanishi, Masayuki Chuma, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yasushi Kirino, Toshimi Nakamura, Kazuhiko Teraoka, Yasumasa Ikeda, Hiromichi Fujino, Hiroaki Yanagawa, Toshiaki Tamaki and Keisuke Ishizawa :
Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database.,
Supportive Care in Cancer, Vol.27, No.3, 849-856, 2019.
(DOI: 10.1007/s00520-018-4367-y,   PubMed: 30062585)
7. Masateru Kondo, Masaki Imanishi, Keijo Fukushima, Raiki Ikuto, Yoichi Murai, Yuya Horinouchi, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya and Keisuke Ishizawa :
Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-induced Aortic Fibrosis.,
American Journal of Hypertension, Vol.32, No.3, 249-256, 2019.
(DOI: 10.1093/ajh/hpy157,   PubMed: 30351343)
8. Naoto Okada, Takahiro Niimura, Yoshito Zamami, Hirofumi Hamano, Shunsuke Ishida, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Masaki Imanishi and Keisuke Ishizawa :
Pharmacovigilance evaluation of the relationship between impaired glucose metabolism and BCR-ABL inhibitor use by using an adverse drug event reporting database.,
Cancer Medicine, 2018.
(DOI: 10.1002/cam4.1920,   PubMed: 30561126)
9. Naoto Okada, Hitoshi Kawazoe, Kenshi Takechi, Yoshihiro Matsudate, Ryo Utsunomiya, Yoshito Zamami, Mitsuhiro Goda, Masaki Imanishi, Masayuki Chuma, Noriaki Hidaka, Koji Sayama, Yoshiaki Kubo, Akihiro Tanaka and Keisuke Ishizawa :
Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study.,
Clinical Therapeutics, Vol.41, No.1, 59-67, 2018.
(DOI: 10.1016/j.clinthera.2018.11.004,   PubMed: 30528047,   Elsevier: Scopus)
10. Yoshito Zamami, Y Kouno, T Niimura, Masayuki Chuma, T Imai, M Mitsui, T Koyama, M Kayano, Naoto Okada, H Hamano, Mitsuhiro Goda, Masaki Imanishi, Kenshi Takechi, Yuya Horinouchi, Y Kondo, Hiroaki Yanagawa, Y Kitamura, T Sendo, Y Ujike and Keisuke Ishizawa :
Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation.,
Die Pharmazie, Vol.73, No.12, 740-743, 2018.
(DOI: 10.1691/ph.2018.8711,   PubMed: 30522561)
11. Masaki Imanishi, Yuki Izawa-Ishizawa, T Sakurada, Y Kohara, Yuya Horinouchi, E Sairyo, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Keijo Fukushima, Yasumasa Ikeda, Hiromichi Fujino, M Yoshizumi, Koichiro Tsuchiya, Toshiaki Tamaki and Keisuke Ishizawa :
Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation.,
Pharmacology, Vol.102, No.5-6, 281-286, 2018.
(DOI: 10.1159/000492577,   PubMed: 30253416,   Elsevier: Scopus)
12. Shunsuke Ishida, Kenshi Takechi, Hiroshi Bando, Masaki Imanishi, Yoshito Zamami, Masayuki Chuma, Hiroaki Yanagawa, Yasushi Kirino, Toshimi Nakamura, Kazuhiko Teraoka and Keisuke Ishizawa :
Development and pharmacist-mediated use of tools for monitoring atypical antipsychotic-induced side effects related to blood glucose levels.,
Pharmacoepidemiology and Drug Safety, 2018.
(徳島大学機関リポジトリ: 112203,   DOI: 10.1002/pds.4656,   PubMed: 30221424)
13. Takahiro Niimura, Yoshito Zamami, Toru Imai, Kanako Nagao, Masafumi Kayano, Hidenori Sagara, Mitsuhiro Goda, Naoto Okada, Masayuki Chuma, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Tadashi Koga, Hironori Nakura, Toshiaki Sendo and Keisuke Ishizawa :
Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit.,
Journal of Pharmacy & Pharmaceutical Sciences, Vol.21, No.1, 54-59, 2018.
(DOI: 10.18433/jpps29737,   PubMed: 29455711,   Elsevier: Scopus)
14. Shiho Sato, Yoshito Zamami, Toru Imai, Satoshi Tanaka, Toshihiro Koyama, Takahiro Niimura, Masayuki Chuma, Tadashi Koga, Kenshi Takechi, Yasuko Kurata, Yutaka Kondo, Yuki Izawa-Ishizawa, Toshiaki Sendo, Hironori Nakura and Keisuke Ishizawa :
Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia.,
Scientific Reports, Vol.7, No.1, 2017.
(徳島大学機関リポジトリ: 112393,   DOI: 10.1038/s41598-017-13073-0,   PubMed: 28978927,   Elsevier: Scopus)

国際会議:

1. Yoshito Zamami, Yuki Izawa-Ishizawa, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Masayuki Chuma, Yuya Horinouchi, Yasumasa Ikeda, Koichiro Tsuchiya and Keisuke Ishizawa :
Drug repositioning for post cardiopulmonary resuscitation syndrome using large-scale medical claims,
FIP2018, グラスゴー, Sep. 2018.
2. Hiroaki Yanagawa, Rumi Katashima, Sato Chiho, Kenshi Takechi, Hiroshi Nokihara, Chikako Kane, Aoe Yuki, Okayama Yoshihiro and Masayuki Chuma :
Research ethics consultation: an attempt and five-year experience in a Japanese University Hospital,
the 18th World Congress of Basic and Clinical Pharmacology (WCP2018)., Japan, Jul. 2018.

国内講演発表:

1. 斉家 和仁, 合田 光寛, 伊勢 諒, 新村 貴博, 石澤 有紀, 座間味 義人, 中馬 真幸, 岡田 直人, 武智 研志, 今西 正樹, 池田 康将, 演野 裕章, 堀ノ内 裕也, 土屋 浩一郎, 石澤 啓介 :
シスプラチン誘発腎障害に対する脂質異常症治療薬の影響,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 2018年11月.
2. 生藤 来希, 今西 正樹, 山川 祐介, 福島 圭穣, 前川 晃子, 堀ノ内 裕也, 石澤 有紀, 合田 光寛, 座間味 義人, 武智 研志, 中馬 真幸, 池田 康将, 藤野 裕道, 土屋 浩一郎 :
大腸がん増大におけるがん関連線維芽細胞由来ERKSの役割,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 2018年11月.
3. 座間味 義人, 近藤 正輝, 阿部 奈都美, 中馬 真幸, 今井 徹, 武智 研志, 今西 正樹, 桐野 靖, 中村 敏己, 寺岡 和彦, 石澤 啓介 :
集中治療における薬剤師教育,
第45回日本集中治療医学会学術集会 委員会企画4(CP4)「集中治療における薬剤師のポジションを考える」, 2018年2月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 医療ビッグデータと基礎・臨床研究を融合したバンコマイシン関連腎障害予防薬の開発 (研究課題/領域番号: 19K16448 )
  • がん転移制御に向けた内皮間葉転換機構とERK5の役割解明 (研究課題/領域番号: 19K07321 )
  • 大規模医療情報と既存承認薬を活用した新たなバンコマイシン関連腎障害予防戦略の開発 (研究課題/領域番号: 18H06107 )
  • 医療ビッグデータと既存承認薬を活用した心肺蘇生後脳症治療薬の開発 (研究課題/領域番号: 18K06785 )
  • 医療ビッグデータと新規モデル動物を応用した大動脈解離発症の病態解明と予防法開発 (研究課題/領域番号: 18K06686 )
  • 研究者番号(20819289)による検索