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en: Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma

ja: 鼻副鼻腔内反性乳頭腫の術後再発に対する血中 SCC 抗原の長期経過の検討

en: Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho

ja: 日本耳鼻咽喉科頭頸部外科学会会報


en: A Case of Solitary Plasmacytoma of the Tongue

ja: 舌に生じた孤立性形質細胞腫例

en: Practica Oto-Rhino-Laryngologica

ja: 耳鼻咽喉科臨床


en: Development and validation of equations for predicting appendicular skeletal muscle mass in male patients with head and neck cancer and normal hydration status

en: Nutrition

ja: Nutrition


en: A Case of Eosinophilic Granulomatosis with Polyangiitis That Developed After the Initial Administration of Dupilumab

ja: デュピルマブ初回投与後に発症した好酸球性多発血管炎性肉芽腫症例


en: Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer.

en: Cancer cachexia is commonly associated with poor prognosis in patients with head and neck cancer (HNC). However, its pathophysiology and treatment are not well established. The current study aimed to assess the muscle mass/quality/strength, physical function and activity, resting energy expenditure (REE), and respiratory quotient (RQ) in cachectic patients with HNC. This prospective cross-sectional study analyzed 64 patients with HNC. Body composition was measured via direct segmental multifrequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity on ultrasonography images. Muscle strength was investigated utilizing handgrip strength and isometric knee extension force (IKEF). Physical function was evaluated using the 10-m walking speed test and the five times sit-to-stand (5-STS) test. Physical activity was examined using a wearable triaxial accelerometer. REE and RQ were measured via indirect calorimetry. These parameters were compared between the cachectic and noncachectic groups. In total, 23 (36%) patients were diagnosed with cachexia. The cachectic group had a significantly lower muscle mass than the noncachectic group. Nevertheless, there was no significant difference in terms of fat between the two groups. The cachectic group had a higher quadriceps echo intensity and a lower handgrip strength and IKEF than the noncachectic group. Moreover, they had a significantly slower normal and maximum walking speed and 5-STS speed. The number of steps, total activity time, and time of activity (<3 Mets) did not significantly differ between the two groups. The cachectic group had a shorter time of activity (≥3 Mets) than the noncachectic group. Furthermore, the cachectic group had a significantly higher REE/body weight and REE/fat free mass and a significantly lower RQ than the noncachectic group. The cachectic group had a lower muscle mass/quality/strength and physical function and activity and a higher REE than the noncachectic group. Thus, REE and physical activity should be evaluated to determine energy requirements. The RQ was lower in the cachectic group than that in the noncachectic group, indicating changes in energy substrate. Further studies must be conducted to examine effective nutritional and exercise interventions for patients with cancer cachexia.

en: Clinical Nutrition ESPEN

ja: Clinical Nutrition ESPEN


en: Effect of Surgical Training Using a Virtual Reality Sinus Simulator in Medical Education

ja: バーチャルリアリティーを用いた内視鏡下鼻副鼻腔手術シミュレーターによる医学教育実習の効果

en: Jpn. J. Rhinol.

ja: 日鼻誌


en: Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house dust mite allergens in patients with allergic rhinitis sensitized to multiple allergens.

en: 3b, a case-controlled study.

ja: 3b, a case-controlled study.


en: Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma.

en: These findings suggest that SCCA can be a tumor marker of IP. It is also suggested that postoperative elevation of SCCA levels is a clinical marker for monitoring the recurrence of IP during the follow-up period. A SCCA cut-off value of 1.85 ng/ml postoperatively may predict the subsequent recurrence of IP with high sensitivity and specificity.

en: Auris, Nasus, Larynx

ja: Auris, Nasus, Larynx


en: ナローバンドUVBを発光するLEDを用いたアレルギー性鼻炎の光治療装置の開発

ja: ナローバンドUVBを発光するLEDを用いたアレルギー性鼻炎の光治療装置の開発


en: Effects of sublingual immunotherapy with tablets or drops containing Japanese cedar pollen antigens on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis.

en: It is suggested that SLIT with JCP tablets improved both nasal symptoms and sleep disturbances at peak pollen period in patients with Japanese cedar pollinosis. SLIT with JCP tablets for one year was more effective than SLIT with JCP drops for two years and prophylactic treatment with antihistamines. J. Med. Invest. 69 : 97-100, February, 2022.

en: The Journal of Medical Investigation : JMI


en: Association of phase angle with muscle function and prognosis in patients with head and neck cancer undergoing chemoradiotherapy


en: A Case of Hereditary Angioedema who Underwent Endoscopic Sinus Surgery Under General Anesthesia

ja: 全身麻酔下に内視鏡下鼻内副鼻腔手術を行った遺伝性血管性浮腫例

en:
Hereditary angioedema (HAE) is an inherited disease characterized by angioedema, that is caused by a genetic abnormality of C1-inhibitor (C1-INH). Decrease or functional abnormality of the C1-INH protein leads to excessive production of bradykinin, which causes increased vascular permeability. Patients with HAE present with edema of the face, arms and legs, as also of the larynx and gastrointestinal tract. Notably, airway stenosis caused by laryngeal edema can be fatal. Upper airway surgery under general anesthesia in patients with HAE carries the risk of airway stenosis caused by surgical site edema and by laryngeal edema due to tracheal intubation. In one guideline for the management of HAE, administration of C1-INH (Berinert®P) prior to surgery is recommended as prophylaxis against the development of angioedema.

A 68-year-old female patient with HAE (type 1) was referred to our department with the chief complaint of pain in the right maxilla. She had undergone Caldwell-Luc surgery for sinusitis as a 13-year-old. CT showed two cysts in the right maxilla, and she was diagnosed as having maxillary cysts and scheduled for surgery. As she suffered from frequent attacks of HAE, we administered C1-INH to the patient prior to surgery, according to a guideline for the management of HAE, and the patient underwent endoscopic sinus surgery (ESS) under general anesthesia without HAE attacks during the perioperative period.

ESS under general anesthesia in a patient with HAE carries the risk of angioedema developing at the surgical site and laryngeal edema developing as a result of tracheal intubation. We could safely perform ESS without angioedema developing in the perioperative period, by prophylactic administration of C1-INH according to a guideline for the management of HAE.

en: Practica Oto-Rhino-Laryngologica


en: Effects of sublingual immunotherapy on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis.

en: These findings suggested that SLIT with JC pollen extract suppressed nasal symptoms in patients with JC pollinosis, leading to improvements in AR-related sleep disturbance and daytime troubles with daily life.


en: Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats

en: NA.

ja: Intranasal pre-irradiation with narrow-band UVB dose-dependently inhibited sneezes and upregulation of H1R gene expression of the nasal mucosa in AR model rats, suggesting that the inhibition of nasal upregulation of H1R gene expression suppressed nasal symptom. The suppression after narrow-band UVB irradiation at a dose of 600 mJ/cm


en: Transnasal Endoscopic Surgery for Juvenile Angiofibroma Involving the Pterygopalatine Fossa

ja: 経鼻内視鏡手術にて摘出した翼口蓋窩に進展した若年性血管線維腫例

en: Juvenile angiofibroma (JA) is an uncommon, locally invasive, highly vascular and benign tumor that occurs in adolescent males. Established external surgical procedures for resection of JA include lateral rhinotomy, midfacial degloving, and transpalatal or infratemporal approaches; however, transnasal endoscopic approaches are increasingly being used because of advances in surgical techniques and endoscopic instrumentation. We report the case of a 14-year-old male who presented with left nasal obstruction and repeated epistaxis. A smooth reddish and hemorrhagic tumor was found in the left posterior nasal cavity. Computed tomography and magnetic resonance imaging showed a markedly enhanced tumor of approximately 40 mm in diameter that had obstructed the left posterior nasal cavity and nasopharynx, with occupancy of the pterygopalatine fossa. The case was diagnosed as Radkowski stage IIB. Preoperative embolization was performed to reduce tumor vascularity and improve visualization for surgical removal. Transnasal endoscopic surgery was used to resect the tumor en bloc after clipping the left maxillary artery. Intraoperative bleeding was 80 mL. To prevent recurrence, careful attention must be paid to tumor invasion into the Vidian canal. The postoperative course of our patient was uneventful, and there has been no evidence of recurrence for over one and a half years since surgery.

ja: 若年性血管線維腫は思春期男子に好発し，頻回の鼻出血や鼻閉をきたす比較的稀な良性腫瘍である．治療の第一選択は手術であるが，非常に血流に富む腫瘍のため，従来は経上顎洞法，外側鼻切開法，経口蓋法などが行われてきた．近年は手術手技や機器の発展に伴い内視鏡下摘出術の適応が広がってきている．今回，我々は経鼻内視鏡手術で摘出した翼口蓋窩に進展した若年性血管線維腫例を経験したので報告する．症例は14歳男性で左鼻閉と反復する鼻出血を主訴に近医耳鼻科を受診し，左鼻腔内に腫瘍性病変を指摘され，当科紹介となった．初診時の鼻内所見では左鼻腔後方に表面平滑な赤色腫瘤を認めた．画像所見にて左鼻腔後方から上咽頭，そして翼口蓋窩を占拠する著明な造影効果のある腫瘤を認め，血管造影で栄養血管を確認し若年性血管線維腫のRadkowskiの分類StageIIBと診断した．術中の出血を抑制するために，手術当日に選択的血管塞栓療法を施行した．経鼻内視鏡下に腫瘍を一塊に摘出し，術中の出血を80 mlに抑制できた．若年性血管線維腫の再発部位は翼突管が最多であると報告されており，摘出術では翼突管への腫瘍の残存に注意する必要があると考えられた．

en: Japanese Journal of Rhinology

ja: 日本鼻科学会会誌


en: Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells.

en: The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in HeLa cells. Sixteen healthy participants were given INCS once daily for a week. After pretreatment of dexamethasone, HeLa cells were treated with histamine. Levels of H1R mRNA and phosphorylation of ERK were measured using real time PCR and immunoblot analysis, respectively. Levels of H1R mRNA in the nasal mucosa of healthy participants receiving INCS was significantly decreased. Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. These data suggested that corticosteroid inhibited both basal transcription and histamine-induced transcriptional activation of H1R through its suppression of ERK phosphorylation in the signaling pathway involved in H1R gene transcription. It is further suggested that pre-seasonal prophylactic administration of INCS suppresses both basal and pollen-induced upregulation of H1R gene expression in the nasal mucosa of patients with pollinosis, leading to prevention of the exacerbation of nasal symptoms during peak pollen season. J. Med. Invest. 67 : 311-314, August, 2020.

ja: The Journal of Medical Investigation : JMI


en: A Case of Rosai-Dorfman Disease with Multiple Extranodal Lesion

ja: 多発する節外病変を認めたRosai-Dorfman病例

en: Rosai-Dorfman disease is a rare histiocytic disorder characterized by accumulation of histiocytes in the affected tissue. Herein we report on a case of Rosai-Dorfman disease with multiple lymphadenopathy and multiple extranodal lesions. A 22-year-old woman was referred to our hospital with bilateral submandibular swelling and a localized swelling in the root of the nose. Endoscopic examination revealed mass lesions in both nasal cavities and the subglottic area. A full-body CT revealed multiple nasal masses, cervical lymphadenopathy, and an intrathymic mass. We diagnosed her as having Rosai-Dorfman disease based on the histopathological findings of accumulation of histiocytes and emperipolesis in the nasal lesion and cervical lymph node specimens. Histopathological examination is required for the diagnosis of Rosai-Dorfman disease. After steroid treatment for 3 months, reduction in the size of the lymph nodes in the neck, nasal cavity lesions, and intrathymic mass was noted. However, the size of the subglottic mass remained almost unchanged. In this case, steroid treatment was mostly effective on the lesions. In case of airway obstruction due to increase in the size of the subglottic mass, surgical resection should be indicated.


en: ヒスタミンH1受容体とIL-33遺伝子発現亢進に対する小青竜湯の抑制効果

ja: ヒスタミンH1受容体とIL-33遺伝子発現亢進に対する小青竜湯の抑制効果


en: Effect of Surgical Training Using a Virtual Reality Temporal Bone Simulator in Medical Education

ja: 医学教育におけるバーチャルリアリティーを用いた側頭骨手術シミュレーション実習の効果

en:
 To estimate the effects of a virtual reality temporal bone simulator in medical education.

 Two hundred and thirty-five medical students undergoing bedside learning were recruited in this study for two years. The same instructor provided the training during the first year, while several instructors provided the training, based on a guidance manual, during the second year. We examined the students' knowledge of anatomy of the temporal bone and administered a questionnaire to determine their comprehension of surgical procedures involving the temporal bone after the training as compared to the level of understanding before the training.

 The percentage of correct answers in the examination of anatomical knowledge about the temporal bone after the simulation in the first and second year improved from 51.8% to 83.9% and 49.4% to 80.0%, respectively. The percentages of medical students who responded with "well understood" or "I think I understood" to questions in the questionnaire on comprehension of surgical procedures involving the temporal bone in the first and second year were 84.3% and 76.4% for mastoidectomy, 74.8% and 66.4% for tympanotomy and 67.8% and 52.3% for cochleostomy, respectively. The anatomical and surgical comprehension levels, except for the case of cochleostomy, did not differ between students who received instructions from several instructors and those who received from the same instructor in this study. The training using a virtual reality temporal bone simulator was useful to improve the students' anatomical knowledge about the temporal bone and their comprehension of surgical procedures involving the temporal bone, and to unify the training content, regardless of the instructor because of standardization and customization of the surgical procedure. Thus, the training using a virtual reality temporal bone simulator is one of the most effective tools of medical education for both medical students and instructors.

en: Journal of Otolaryngology of Japa

ja: 日本耳鼻咽喉科学会会報