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en: Transport characteristics of placenta-derived extracellular vesicles and its relevance to placenta-to-maternal tissues communication.

en: The placenta, a unique organ that helps maintain a healthy pregnancy, plays a pivotal role in maternal adaptation to pregnancy and releases extracellular vesicles (EVs), autacoids, and hormones. EVs are membranous vesicles released by all types of cells, including placental trophoblasts, which are involved in intracellular communication by delivering their cargo, such as proteins, nucleic acids, and lipids, to the targeted cells in a neighboring or distant location. Recently, an increasing number of publications have reported that EVs secreted from the placenta into maternal circulation deliver their cargo to maternal organs and mediate placenta-to-maternal communication during pregnancy. This review provides an overview of the transport mechanism of placenta-derived EVs to maternal organs.

en: Chemical & Pharmaceutical Bulletin

ja: Chemical & Pharmaceutical Bulletin


en: ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.

en: We conclude that transcriptional regulation by ATF4 maintains β-cell identity via ISR modulation. This mechanism provides a promising target for the treatment of diabetes.

ja: To examine the role of ATF4 in vivo, ISR enhancer Sephin1 (5 mg/kg body weight, p.o.) was administered daily for 21 days to Akita mice. We also established β-cell-specific Atf4 knockout (βAtf4-KO) mice that were further crossed with Akita mice. These mice were analyzed for characteristics of diabetes, β-cell function, and morphology of the islets. To identify the downstream factors of ATF4 in β-cells, the islets of βAtf4-KO mice were subjected to cDNA microarray analyses. To examine the transcriptional regulation by ATF4, we also performed in situ PCR analysis of pancreatic sections from mice and ChIP-qPCR analysis of CT215 β-cells.

en: Molecular Metabolism

ja: Molecular Metabolism


en: Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes.

en: American Journal of Physiology, Gastrointestinal and Liver Physiology


en: Continuous release of O2/ONOO in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation.

en: Plasma Processes and Polymers

ja: Plasma Processes and Polymers