徳島大学 / 教育研究者総覧 --- 曽我部周

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研究テーマ

著書・論文

学術論文(審査論文):

1.	Shu Sogabe, HABOSHI Tatsuya, Izumi Yamaguchi, Masaaki Korai, Nobuaki Yamamoto, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi : Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion, Surgical Neurology International, Vol.14, No.365, 365, 2023. (要約) We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_608_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37941628 ● Search Scopus @ Elsevier (PMID): 37941628 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_608_2023 (DOI: 10.25259/SNI_608_2023, PubMed: 37941628)
2.	Yuki Yamamoto, Nobuaki Yamamoto, Tomohiro Matsuda, Kazutaka Kuroda, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases., Surgical Neurology International, Vol.14, 274, 2023. (要約) In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_513_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37680937 ● Search Scopus @ Elsevier (PMID): 37680937 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_513_2023 (DOI: 10.25259/SNI_513_2023, PubMed: 37680937)
3.	Nobuaki Yamamoto, Kazutaka Kuroda, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Ryoma Morigaki, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot, Internal Medicine, Vol.62, No.6, 909-913, 2023. (要約) Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion. (キーワード) mechanical thrombectomy / long-sheath introducer / giant clot / cerebral large-vessel occlusion (徳島大学機関リポジトリ) ● Metadata: 118794 (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.0089-22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35945008 ● CiNii @ 国立情報学研究所 (CRID): 1390576900004177024 ● Search Scopus @ Elsevier (PMID): 35945008 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0089-22 (徳島大学機関リポジトリ: 118794, DOI: 10.2169/internalmedicine.0089-22, PubMed: 35945008, CiNii: 1390576900004177024)
4.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 循環器病を防ぐために徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 四国医学雑誌, Vol.78, No.5-6, 135-138, 2022年. (要約) Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city. (キーワード) Cerebrovascular and cardiovascular disease / emergency transportation systems / prehospital scale (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050295181679880704 (CiNii: 1050295181679880704)
5.	山本雄貴, 山本伸昭, 黒田一駿, 和泉唯信, 兼松康久, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志 : 徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,, 四国医学雑誌, Vol.78, No.5,6, 248-249, 2022年.
6.	Kenji Shimada, Kazuhisa Miyake, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Yasuhisa Kanematsu and Yasushi Takagi : Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery, World Neurosurgery, Vol.169, e260-e269, 2022. (要約) An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery. (徳島大学機関リポジトリ) ● Metadata: 118079 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2022.10.121 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36332776 ● Search Scopus @ Elsevier (PMID): 36332776 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2022.10.121 (徳島大学機関リポジトリ: 118079, DOI: 10.1016/j.wneu.2022.10.121, PubMed: 36332776)
7.	Kenji Shimada, Izumi Yamaguchi, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yasuhisa Kanematsu and Yasushi Takagi : Efficacy of intraarterial indocyanine green videoangiography in surgery for arteriovenous fistula at the craniocervical junction in a hybrid operating room: illustrative cases, Journal of Neurosurgery. Case Lessons, Vol.3, No.23, 1-6, 2022. (要約) Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Case 1 involved a 71-year-old man presenting with tetraparesis after sudden onset of severe headache due to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) demonstrated CCJ epidural AVF. Intraarterial ICG videoangiography revealed the drainer, which had been difficult to identify. The AVF disappeared after disconnection of the drainer. Case 2 involved a 68-year-old man presenting with severe headache due to SAH. DSA showed multiple AVFs at the CCJ and cerebellar tentorium. Intraarterial ICG videoangiography demonstrated concomitant perimedullary AVF and dural AVF at the CCJ. All AVFs disappeared postoperatively. Intraarterial ICG videoangiography was useful for definitive diagnosis of CCJ AVF, facilitating identification of feeders and drainers with bright and high phase contrast and allowing repeated testing to confirm flow direction. (出版サイトへのリンク) ● Publication site (DOI): 10.3171/CASE22100 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35733826 ● Search Scopus @ Elsevier (PMID): 35733826 ● Search Scopus @ Elsevier (DOI): 10.3171/CASE22100 (DOI: 10.3171/CASE22100, PubMed: 35733826)
8.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, 山本陽子, Kazutaka Kuroda and Yasushi Takagi : Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case, Journal of Neurosurgery. Case Lessons, Vol.3, No.21, CASE2267, 2022. (要約) Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms. (出版サイトへのリンク) ● Publication site (DOI): 10.3171/CASE2267 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35734231 ● Summary page in Scopus @ Elsevier: 2-s2.0-85160834258 (DOI: 10.3171/CASE2267, PubMed: 35734231, Elsevier: Scopus)
9.	Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kenji Shimada, Yasushi Takagi and Yuishin Izumi : The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation, Surgical Neurology International, Vol.13, No.72, 1-7, 2022. (要約) Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the "claw sign," was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke. (徳島大学機関リポジトリ) ● Metadata: 117192 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_1160_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35242438 ● Search Scopus @ Elsevier (PMID): 35242438 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_1160_2021 (徳島大学機関リポジトリ: 117192, DOI: 10.25259/SNI_1160_2021, PubMed: 35242438)
10.	Izumi Yamaguchi, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Yoshiteru Tada, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Hiroshi Kagusa, Yoko Yamamoto, Taku Matsuda, Keiko T. Kitazato, Yoshihiro Okayama and Yasushi Takagi : Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study, Journal of Clinical Neuroscience, Vol.94, 244-249, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jocn.2021.10.037 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2021.10.037 (DOI: 10.1016/j.jocn.2021.10.037)
11.	Kenji Shimada, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yoshiteru Tada, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi : Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations, World Neurosurgery, E1-E7, 2021. (要約) Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs. (徳島大学機関リポジトリ) ● Metadata: 116871 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2021.08.118 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34478890 ● Summary page in Scopus @ Elsevier: 2-s2.0-85115331132 (徳島大学機関リポジトリ: 116871, DOI: 10.1016/j.wneu.2021.08.118, PubMed: 34478890, Elsevier: Scopus)
12.	Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi : Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report., Surgical Neurology International, Vol.12, No.347, 2021. (要約) The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_533_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487 ● Search Scopus @ Elsevier (PMID): 34345487 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021 (DOI: 10.25259/SNI_533_2021, PubMed: 34345487)
13.	Kenji Shimada, Yoko Yamamoto, Takeshi Miyamoto, Shu Sogabe, Toshitaka Fujihara, Kohhei Nakajima, Yoshifumi Mizobuchi, Yasuhisa Kanematsu and Yasushi Takagi : Efficacy of Intra-arterial Indocyanine Green Videoangiography in Hemangioblastoma Surgery: A Case Report., NMC Case Report Journal, Vol.8, No.1, 295-300, 2021. (要約) Intravenous indocyanine green (ICG) videoangiography is reportedly useful for vascular neurosurgery, and for treating hemangioblastoma due to its high vascularity. Videoangiography obtained after intra-arterial ICG injection has emerged as a more useful option than that after intravenous injection. This report offers the first description of a case of hemangioblastoma successfully treated using intra-arterial ICG videoangiography, and describes the efficacy of this technique. A 20-year-old man presented with progressive cerebellar ataxia and dysphagia. Magnetic resonance imaging (MRI) revealed an enhanced solid tumor in the medulla oblongata. Digital subtraction angiography (DSA) showed a highly vascularized tumor. Surgery was performed to remove the tumor in a hybrid operating room. A catheter was introduced into the vertebral artery (VA) for intra-arterial ICG videoangiography. Superficial feeders and drainers were identified and flow dynamic changes in the tumor were assessed by intra-arterial ICG videoangiography. The tumor was removed after confirming lack of flow in the drainer. Intra-arterial ICG videoangiography was more useful than intravenous ICG videoangiography in hemangioblastoma surgery for identifying feeders and drainers and assessing flow dynamics in the tumor. Use of Flow 800 made these findings simpler and easier to evaluate. (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmccrj.cr.2020-0281 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35079478 ● Search Scopus @ Elsevier (PMID): 35079478 ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2020-0281 (DOI: 10.2176/nmccrj.cr.2020-0281, PubMed: 35079478)
14.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki, Yuishin Izumi and Yasushi Takagi : Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter, Journal of Neuroendovascular Therapy, Vol.16, No.5, 277-282, 2021. (要約) <p><b>Objective</b>: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.</p><p><b>Case Presentations</b>: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.</p><p><b>Conclusion</b>: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.</p> (キーワード) percutaneous transluminal angioplasty / aspiration catheter (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.cr.2021-0030 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390573593425698304 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2021-0030 (DOI: 10.5797/jnet.cr.2021-0030, CiNii: 1390573593425698304)
15.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Kohhei Nakajima, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Mai Azumi, Ayato Kageyama and Yasushi Takagi : Gelatinthrombin Hemostatic Matrix-related Cyst Formation after Cerebral Hematoma Evacuation: A Report of Two Cases, NMC Case Report Journal, Vol.8, No.1, 719-725, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.2176/nmccrj.cr.2021-0130 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2021-0130 (DOI: 10.2176/nmccrj.cr.2021-0130)
16.	Nobuaki Yamamoto, Yuishin Izumi, Yuki Yamamoto, K Kuroda, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki and Yasushi Takagi : Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion, Clinical Neurology and Neurosurgery, Vol.199, 106316, 2020. (要約) The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Cerebrovascular Disorders / Diffusion Magnetic Resonance Imaging / Female / Humans / Ischemic Stroke / Male / Middle Aged / Patient Admission / Prospective Studies / Retrospective Studies / Severity of Illness Index (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clineuro.2020.106316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33161217 ● Search Scopus @ Elsevier (PMID): 33161217 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2020.106316 (DOI: 10.1016/j.clineuro.2020.106316, PubMed: 33161217)

学術論文(紀要・その他):

1.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi : Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series, Operative Neurosurgery, Vol.25, No.3, 292-300, 2023. (要約) Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery. (キーワード) Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1227/ons.0000000000000796 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942 ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953 (DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus)

国内講演発表:

1.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真美, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 2023年11月.
2.	兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 髙木康志 : ICT, 2023年11月.
3.	島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて, 日本脳神経外科学会第82回学術集会, 2023年10月.
4.	曽我部周, 兼松康久, 山口泉, 山本伸昭, 島田健司, 髙木康志 : もやもや病に合併した頭蓋内内頚動脈閉塞に対して再開通療法をおこなった1例, 脳血管内治療ブラッシュアップセミナー2023, 2023年7月.
5.	山本伸昭, 黒田一駿, 山本雄貴, 和泉唯信, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志 : First pass TICI2B患者の追加治療における意義, 第64回日本神経学会学術大会, 2023年5月.
6.	島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 : VM摘出術における3D multimodal fusion imageとindocyanine green動注による術中videoangiography併用の有用性, 第32回脳神経外科手術と機器学会(CNTT2023), 2023年4月.
7.	手島奈津美, 安積麻衣, 中島公平, 松田知大, 山口泉, 藤原敏孝, 曽我部周, 原慶次郎, 髙木康志 : 術後管理に難渋した頭蓋咽頭腫の1例, 第95回日本脳神経外科学会中国四国支部学術集会, 2023年4月.
8.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第48回日本脳卒中学会学術集会, 2023年3月.
9.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, STROKE2023, 2023年3月.
10.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での低ASPECTS症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 第48回日本脳卒中学会学術集会, 2023年3月.
11.	山口泉, 兼松康久, 溝渕佳史, 多田恵曜, 宮本健志, 曽我部周, 石原学, 鹿草宏, 山本陽子, 松田拓, 北里慶子, 髙木康志 : 硬膜転移が慢性硬膜下血腫の転帰に及ぼす影響についての後視的検討, 第46回日本脳神経外傷学会, 2023年2月.
12.	松田拓, 鹿草宏, 山口泉, 曽我部周, 島田健司, 兼松康久, 髙木康志, 近藤心, 佐藤紀, 梅村公子, 松浦哲也 : 急性期脳卒中患者におけるロボットスーツHALの即時効果についての検討, 四国医学雑誌, Vol.78, No.5-6, 245, 2022年12月.
13.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 和泉唯信, 髙木康志 : 当院の主幹動脈閉塞低ASPECT症例の拡散強調画像に対するRAPIDでの後方視的定量評価, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
14.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 地方都市における救急医療連携アプリケーションを用いたLVO診断スケールの活用, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
15.	山本伸昭, 黒田一駿, 山本雄貴, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 病院前スケール，iSchemaView RAPID導入前後の比較検討, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
16.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志, 和泉唯信 : 9Fr long sheathを用いた巨大血栓によるLVO治療例, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
17.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
18.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での主幹動脈閉塞-低ASPECT症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 日本脳神経外科学会第81回学術総会, 2022年9月.
19.	兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 : 徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み, 日本脳神経外科学会第81回学術総会, 2022年9月.
20.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いたLVO診断スケールの活用(FAST-ED Tokushima), 第24回中国四国脳卒中研究会, 2022年9月.
21.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 徳島医学会学術集会, 2022年7月.
22.	原慶次郎, 溝渕佳史, 安積麻衣, 曽我部周, 藤原敏孝, 中島公平, 髙木康志 : Hyper vascularityを呈した松果体部腫瘍の1例, 第93回日本脳神経外科学会中国四国支部学術集会, 2022年4月.
23.	島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 : AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性, 第51回日本脳卒中の外科学会学術集会, 2022年3月.
24.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : open-cell stentにclosed-cell stentをオーバーラップさせたCASの治療成績, STROKE2022, 2022年3月.
25.	松田拓, 近藤心, 佐藤紀, 梅村公子, 曽我部周, 加藤真介, 兼松康久, 髙木康志 : ロボットスーツHALの脳卒中急性期患者における即時効果の検討, STROKE2022, 2022年3月.
26.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈を直線穿刺することで治療し得たTSS d-AVFの1例, 近畿脳神経血管内手術法ワークショップ, 2022年1月.
27.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈の直線穿刺によるTVEを行ったTSS d-AVFの1例, 第92回日本脳神経外科学会中国四国支部会, 2021年12月.
28.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 一期的にopen-cell stentにclosed-cell stentを重ねたCASの初期治療成績, 日本脳神経血管内治療学会, 2021年11月.
29.	宮本健志, 曽我部周, 兼松康久, 四方英二, 山口泉, 石原学, 島田健司, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞に対して急性期再開通療法後MRIのRibbon signの特徴, 日本脳神経血管内治療学会, 2021年11月.
30.	兼松康久, 金澤裕樹, 島田健司, 曽我部周, 宮本健志, 石原学, 四方英二, 山口泉, 多田恵曜, 山本雄貴, 山本伸昭, 原田雅史, 髙木康志 : CEST MRIを用いた頚動脈プラーク診断 Chemical exchange saturation transfer MRI for carotid plaque imaging, NMC Case Report Journal, 2021年10月.
31.	島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 : AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性, NMC Case Report Journal, 2021年10月.
32.	宮本健志, 山口泉, 四方英二, 石原学, 曽我部周, 島田健司, 兼松康久, 髙木康志 : 閉塞性血管障害に対する血行再建術後におけるArterial spin-labelingの変化, NMC Case Report Journal, 2021年10月.
33.	曽我部周, 兼松康久, 山口泉, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 当院でのopen-cell stentとclosed-cell stentの2枚重ねでのCASの治療成績, NMC Case Report Journal, 2021年10月.
34.	山口泉, 兼松康久, 島田健司, 山本伸昭, 宮本健志, 曽我部周, 石原学, 山本雄貴, 髙木康志 : 硬膜動静脈瘻の診断におけるArterial spin-labelingの有用性の検討 Usefulness of Arterial Spin-Labeling for diagnosis of dural arteriovenous fistulae, 日本脳神経外科学会第80回学術総会, 2021年10月.
35.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞における有効再開通が得られた患者における予後関連因子, 第23回中国四国脳卒中研究会, 2021年9月.
36.	島田健司, 山本陽子, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 : AVM摘出術におけるHybrid手術室でのインドシアニン・グリーン動注による術中videoangiographyの有用性, 第44回日本脳神経Cl学会総会, 2021年4月.
37.	島田健司, 山口泉, 宮本健志, 曽我部周, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 : 海綿静脈洞部硬膜動静脈瘻におけるshunted pouchと頭蓋底骨の関係, 第46回日本脳卒中学会学術集会, 2021年3月.
38.	兼松康久, 島田健司, 曽我部周, 宮本健志, 石原学, 山口泉, 山本雄貴, 山本伸昭, 髙木康志 : 当施設における巨大血栓化脳動脈瘤に対する治療成績, 第46回日本脳卒中学会学術集会, 2021年3月.
39.	宮本健志, 曽我部周, 兼松康久, 島田健司, 山口泉, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 脳梗塞急性期再開通療法後MRIの急性期ribbon signの特徴, 第46回日本脳卒中学会学術集会, 2021年3月.
40.	石原学, 兼松康久, 山本伸昭, 曽我部周, 宮本健志, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS5点以下軽症脳主幹動脈閉塞症例における転帰, 第25回日本脳神経外科救急学会, 2020年2月.
41.	山本陽子, 兼松康久, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 髙木康志 : Neckからfetal typeのPcomが起始する大型血栓化IC-PC動脈瘤に対しステント併用下コイル塞栓術を行った一例, 第88回(一社)日本脳神経外科学会中国四国支部学術集会, 2019年12月.

その他・研究会:

1.	山口真司, 宮本健志, 曽我部周, 佐藤紀, 兼松康久, 髙木康志 : 二期的に治療を行った左中大脳動脈の巨大血栓化動脈瘤の1例, 第31回石打カンファランス, 2020年2月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

脳動静脈奇形における血管内皮のKRAS変異とPAD4活性化の関係 (研究課題/領域番号: 22K09259 )
研究者番号（70883718）による検索

助教, 特任助教 : 曽我部周

研究活動

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教, 特任助教 : 曽我部 周

研究活動

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教, 特任助教 : 曽我部周