A case of adult T-cell leukemia/lymphoma showing CD8 positive and CD25 negative by immunohistochemistry

免疫染色にてCD8陽性,CD25陰性を示した成人T細胞白血病リンパ腫の1例


Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT

This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023.

The Journal of Medical Investigation : JMI


Effectiveness of radiation therapy for skin lesions of blastic plasmacytoid dendritic cell neoplasm: A case report.

芽球性形質細胞様樹状細胞腫瘍の皮膚病変に対して放射線療法が有効であった一例

Journal of the Japan Organization of Clinical Dermatologists


A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages

Various cells, such as macrophages and hepatic stellate cells, interact in the generation of fibrosis in nonalcoholic steatohepatitis (NASH), but the mechanism remains unclear. We employed a high-fat/cholesterol/cholate (HFCC) diet to generate a model of NASH-related fibrosis and investigate the pathogenesis of fibrosis. Two mouse strains differing in susceptibility to obesity, the susceptible strain C57BL/6J and the relatively resistant strain A/J, developed hepatic histologic features of NASH, including fat deposition, intralobular inflammation, hepatocyte ballooning, and fibrosis, after 9 weeks of HFCC diet feeding. The severity of hepatic inflammation and fibrosis was greater in A/J mice than in C57BL/6J mice. A/J mice fed the HFCC diet exhibited characteristic CD204-positive lipid-laden macrophage aggregation in hepatic parenchyma. Polarized light visualized the Maltese cross (namely, cholesterol crystals within the aggregated macrophages). Moreover, fibrosis developed in a ring shape from the periphery of the aggregated macrophages (ie, the starting point of fibrosis could be visualized histologically). Furthermore, matrix-assisted laser desorption/ionization mass spectrometry imaging analysis detected a molecule at m/z 772.462, which corresponds to the protonated ion of phosphatidylcholine [P-18:1 (11Z)/18:0] and phosphatidylethanolamine [18:0/20:2 (11Z, 14Z)], in aggregated macrophages adjacent to the fibrotic lesions. In conclusion, the present HFCC diet-fed A/J model provides an ideal tool to study fibrogenesis and enables novel insights into the pathophysiology of NASH-related fibrosis.


Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.

Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. An insulin-recruitment to DIAR-nSTZ mice showed an increased frequency of HCC during the first 12 weeks of age, although the diabetic indications notably improved. To elucidate the role of hyperglycemia in hepato-carcinogenesis, we performed a head-to-head comparative study by using 4CS mice and DIAR mice with n-STZ treatment. Newborn 4CS mice and DIAR mice were divided into STZ treated group and control group. The blood glucose levels of DIAR-nSTZ mice increased at age of eight weeks, while that of 4CS-nSTZ mice were maintained in the normal range. At eight weeks old, three out of five DIAR-nSTZ mice (60%) and one out of ten 4CS-nSTZ mice (10%) developed multiple liver tumors. At age of 12 weeks old, all eight of DIAR-nSTZ mice (100%) and two of 10 4CS-nSTZ mice (20%) developed multiple liver tumors. At 16 weeks old, all animals of DIAR-nSTZ and 4CS-nSTZ mice occurred liver tumors. DIAR-nSTZ showed hyperglycemia and HCC, and 4CS-nSTZ developed HCC without hyperglycemia. These results were interpreted that the onset of HCC maybe not related to the presence or absence of hyperglycemia but nSTZ treatment. On the other hand, since the carcinogenesis of 4CS-nSTZ is delayed compared to DIAR-nSTZ, hyperglycemia may play a role in the progression of carcinogenesis. Histologically, the liver tumor appeared irregularly trabecular arrangements of hepatocytes with various degrees of nuclear atypia. By immunohistochemical analyses, all liver tumors showed positive staining of glutamine synthetase (GS), an established human HCC marker. The expression pattern of GS was divided into a strong diffuse pattern and weak patchy pattern, respectively. The liver tumor showing the weak GS-patchy pattern expressed biliary/stem markers, EpCAM, and SALL4, partially. Because 4CS-nSTZ mice did not show any metabolic complications such as gaining body weight or high blood glucose level, it is a unique animal model with a simple condition to investigate hepatic carcinogenesis by excluding other factors.


Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells.

PESI-MS presented a promising potential as a novel diagnostic modality for swiftly acquiring specific cytological information.


Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity

Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available. Here, based on a repositioning analysis of the Food and Drug Administration Adverse Events Reporting System, we found that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced kidney toxicity. To confirm this, the actual efficacy of diphenhydramine was evaluated in in vitro and in vivo experiments. Diphenhydramine inhibited cisplatin-induced cell death in kidney proximal tubular cells. Mice administered cisplatin developed kidney injury with significant dysfunction (mean plasma creatinine: 0.43 vs 0.15 mg/dl) and showed augmented oxidative stress, increased apoptosis, elevated inflammatory cytokines, and MAPKs activation. However, most of these symptoms were suppressed by treatment with diphenhydramine. Furthermore, the concentration of cisplatin in the kidney was significantly attenuated in diphenhydramine-treated mice (mean platinum content: 70.0 vs 53.4 μg/g dry kidney weight). Importantly, diphenhydramine did not influence or interfere with the anti-tumor effect of cisplatin in any of the in vitro or in vivo experiments. In a selected cohort of 98 1:1 matched patients from a retrospective database of 1467 patients showed that patients with malignant cancer who had used diphenhydramine before cisplatin treatment exhibited significantly less acute kidney injury compared to ones who did not (6.1 % vs 22.4 %, respectively). Thus, diphenhydramine demonstrated efficacy as a novel preventive medicine against cisplatin-induced kidney toxicity.


Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis.

Nonalcoholic steatohepatitis (NASH) progresses to liver fibrosis and cirrhosis. Existing mouse models of NASH rarely develop diet-induced severe fibrosis. We aimed to establish a dietary model of NASH with rapid progression to fibrosis. Six-week-old male Tsumura-Suzuki obese diabetes (TSOD) mice (a model of spontaneous metabolic syndrome) and corresponding control Tsumura-Suzuki nonobese (TSNO) mice were fed a novel diet high in fat, cholesterol, and cholate (iHFC). Histologic steatohepatitis, including steatosis, inflammation, and fibrosis, were observed in both TSNO and TSOD iHFC diet-fed mice at 20 weeks of age. As compared with TSOD mice, TSNO mice developed much more severe fibrosis and reached stage 3 of bridging fibrosis within 14 weeks under the iHFC diet feeding. Perivenular/perisinusoidal pattern of fibrosis in TSNO mice resembled human NASH. Our model of NASH with advanced fibrosis by simple diet offers many advantages useful in studying the mechanism of liver fibrosis and preclinical drug testing.

Bioscience, Biotechnology, and Biochemistry


A study about clinicopathological features of Japanese gastric Hamartomatous inverted polyp (inverted hyperplastic polyp) reported before 2002

2002年以前に報告された日本人胃のHamartomatous inverted polyp (inverted hyperplastic polyp)の臨床病理学的所見の検討

Gastric hamartomatous inverted polyp (g-HIP) is rare gastric elevated lesion forming endophytic growth pattern which etiology remains unknown. G-HIP is said to be associated with gastric cancer and gastritis. We systematically reviewed Japanese g-HIP's clinicopathological features reported before2002. Japanese g-HIP amount to20lesions,18patients ; 7(38 9%)were males and 11(61 1%)were females. The mean age of patients was 60 2 years old. The mean size of the lesions was21 7millimeter. No of the polyp shape was Yamada type IV7, Yamada type I/flat elevation 6, Yamada type III 4 and Yamada II 3, respectively. The site of the lesions was Body11, Cardia3, Fornix3and Antrum1, respectively. In12described cases, accompanied lesion was Gastritis, Carcinoma, GCP, Hyperplastic polyp, GIST and remnant stomach due to ulcer. Of the submucosal shaped(Yamada type I/flat elevation)g-HIP,50% has GCP and62 5% has gastric cancer. The common feature of g-HIP was pyloric gland-like mucous gland proliferation and cystic dilatation in the H. pylori era of Japan.


根治切除9年以上経過後に上縦隔リンパ節再発した食道癌の1例

根治切除9年以上経過後に上縦隔リンパ節再発した食道癌の1例


Extranodal Site and Aggressive Histological Subtype Lead to Undetectable Giemsa Banding in Lymphoid Tumors

リンパ系腫瘍のGiemsa banding法が検査不能となる要因についての一施設検討

The Official Journal of Japanese Society of Laboratory Medicine


Contact granulomatous hypersensitivity to indium in a patient with orofacial granulomatosis.


An Autopsy Case of Brugada Syndrome with Prominent J Wave in the Inferior Leads Presenting Headache and Chest Pain

頭痛と胸痛で発症し，下壁誘導に明瞭な J 波を伴った Brugada 症候群の 1 剖検例


[A Case of Complete Pathological Response in a Patient with Locally Advanced Sigmoid Colon Cancer after FOLFOX IRI Chemotherapy].

A 61-year-old man with advanced sigmoid colon cancer was admitted to our hospital. Abdominal computed tomography (CT) revealed locally advanced sigmoid colon cancer, with suspected invasion of the bladder and small intestine. The clinical stage of the disease was T4b, N1, M0, and Stage III a, with wild-type KRAS expression. A transverse colostomy was performed because of the presence of a bowel obstruction. The patient received 4 courses of Leucovorin, 5-fluorouracil, oxaliplatin, and irinotecan (FOLFOXIRI). The size of the tumor and lymph nodes decreased noticeably after chemotherapy and laparoscopic high anterior resection with lymph node dissection. During this phase, the pathological stage of the disease was ypT0, N0, and Stage 0(no viable carcinoma cells, Grade 3). This result suggested that preoperative FOLFOXIRI chemotherapy is a useful regimen for the treatment of locally advanced colon cancer.

Japanese Journal of Cancer and Chemotherapy


Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma.

Malignant syphilis or lues maligna is a severe form of secondary syphilis that was commonly reported in the pre-antibiotic era, and has now reemerged with the advent of the human immunodeficiency virus (HIV) epidemic. However, the characteristic histopathological findings of malignant syphilis remain controversial. The aim of this case report was to clarify the clinical and histopathological findings of HIV-positive malignant secondary syphilis. A Japanese man in his forties complained of fever, skin lesions, headache, and myalgia without lymphadenopathy during the previous 4 weeks. The skin lesions manifested as erythematous, nonhealing, ulcerated papules scattered on his trunk, extremities, palm, and face. Although the skin lesions were suspected to be cutaneous T-cell lymphomas on histological analyses, they lacked T-cell receptor Jγ rearrangement; moreover, immunohistochemical analyses confirmed the presence of spirochetes. The patient was administered antibiotics and anti-retroviral therapy, which dramatically improved the symptoms. On the basis of these observations of the skin lesions, we finally diagnosed the patient with HIV-associated secondary syphilis that mimicked cutaneous T-cell lymphoma. The patient's systemic CD4+ lymphocyte count was very low, and the infiltrate was almost exclusively composed of CD8+ atypical lymphocytes; therefore, the condition was easily misdiagnosed as cutaneous lymphoma. Although the abundance of plasma cells is a good indicator of malignant syphilis on skin histological analyses, in some cases, the plasma cell count may be very low. Therefore, a diagnosis of malignant secondary syphilis should be considered before making a diagnosis of primary cutaneous peripheral T-cell lymphoma or lymphoma associated with HIV infection.


A Case of a Laryngocele with Recurrent Infection

We report herein on a case of laryngocele with recurrent infection. A 48-year-old male complained of hoarseness and swelling of the left side of his neck. The endoscopic and CT scan examinations demonstrated the combined type of laryngocele that had expanded through the thyrohyoid membrane and had swollen up both medially and laterally in a dumbbell-like shape. To avoid the risk of laryngeal stenosis with the enlarged laryngocele infected by bacteria, in addition to intravenous infusion of an anti-bacterial drug, purulent discharge was drained from the infected laryngocele with a puncture needle. Because infection of the laryngocele was recurrent, it was surgically removed via an external neck approach under general anesthesia without any prophylactic tracheotomy. The laryngocele may be translated from a saccular cyst that had developed after the obstruction of communication between the laryngeal ventricle and the laryngeal saccule.


Surgical treatment for giant thoracic aortic aneurysm in a young patient with autoimmune disease

自己免疫性疾患が原因と考えられる若年巨大胸部大動脈瘤に対する手術経験


A case of native valve endocarditis caused by Staphylococcus lugdunensis


Lymphangioma of the ovary accompanied by chylous ascites.

Lymphangioma of the ovary is very rare, with only 17 cases reported to date. In this report, a 43-year-old woman with lymphangioma of the ovary accompanied by chylous ascites is described. Vaginal ultrasound showed a solid cystic tumor at the right ovary accompanied by ascites. The volume of ascites was changeable. Milky fluid obtained by Douglas pouch aspiration contained numerous mature lymphocytes. She underwent right salpingo-oophorectomy. Histological examination revealed that the excised tumor from the right ovary was consistent with benign lymphangioma. This is the first case report of lymphangioma of the ovary accompanied by chylous ascites. We should discriminate such cases from other malignant tumors in order to avoid overtreatment.

The Journal of Obstetrics and Gynaecology Research


[A case of disseminated bone marrow carcinosis with disseminated intravascular coagulation successfully controlled with S-1 after total gastrectomy for advanced gastric cancer].

S-1によりDIC から離脱し得た胃癌術後播種性骨髄癌症の1 例

Bone marrow carcinosis due to gastric cancer with disseminated intravascular coagulation(DIC)occurs suddenly, progresses rapidly, and has a very poor prognosis. In addition, physical status tends to be bad at the time of the episode, and palliative care is generally selected as the treatment method. The case was a 70-year-old woman who underwent total gastrectomy for scirrhous stomach cancer five years previously. She recently noticed gingival hemorrhage, and was referred to our hospital by a nearby doctor. As a result of her examination, she was diagnosed with disseminated bone marrow carcinosis as a postoperative recurrence of gastric cancer that resulted in DIC. We transfused blood platelets and fresh frozen plasma into her, and controlled the bleeding tendency temporarily. She was started on oral administration of S-1 for improvement of DIC, and the therapy was successful without loss of QOL. It is easy to continue S-1 therapy as chemotherapy in the outpatient department, because it is a matter of internal medicine.


Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association.

Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry.


immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis.

Non-hormone-secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S-100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S-100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type ('CK-type cell') was cells weakly positive for S-100 protein in the nucleus and for CK-immunoreactivity in the cytoplasm. The next numerous type ('S-100 protein cell') was cells strongly positive for S-100 protein and weakly positive or negative for CK. The CK-type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone -immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S-100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so-called stellate cells. GFAP-positive cells were rare. It is implied that S-100 protein-positive FSC could be divided into at least two main subtypes: FC (CK-type cells) and stellate cells (S-100 protein cells).


Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice

Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis, cell differentiation, and regulation of the immune system. Expression of these genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous studies have shown that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined in normocalcemic VDR knock-out (KO) mice on a high calcium diet and compared with wild type and hypocalcemic VDRKO mice that were fed a regular diet. Platelet aggregation was enhanced significantly in normocalcemic VDRKO mice compared with wild type and hypocalcemic VDRKO mice. Aortic endothelial nitric-oxide (NO) synthase expression and urinary NOx excretions were reduced in hypocalcemic VDRKO mice, but not in normocalcemic VDRKO mice. Northern blot and RT-PCR analyses revealed that the gene expression of antithrombin in the liver as well as that of thrombomodulin in the aorta, liver and kidney was down-regulated in hypo- and normocalcemic VDRKO mice. Whereas tissue factor mRNA expression in the liver and kidney was up-regulated in VDRKO mice regardless of plasma calcium level. Furthermore, VDRKO mice manifested an exacerbated multi-organ thrombus formation after exogenous lipopolysaccharide injection regardless of the calcemic conditions. These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis.


Unique cell membrane expression if topoisomerase-ll alpha as a useful diagnostic marker of liposarcoma

Topoisomerase-II alpha (Topo-II alpha) is known as a cell cycle-related intranuclear marker. To the best of our knowledge, the expression of Topo-II alpha on extranuclear sites has not been reported. The aim of the present study was to determine the usefulness of Topo-II alpha immunostaining for detecting the lipoblasts that are essential to diagnosing liposarcoma. Surgical specimens, including benign lipomatous tumors (four cases), well-differentiated liposarcomas (three cases), myxoid liposarcomas (six cases), pleomorphic liposarcomas (two cases), dedifferentiated liposarcomas (two cases), myxoid malignant fibrous histiocytomas (six cases), and one case of mesenteric panniculitis, were studied. Samples were immunostained using antibodies for Topo-II alpha, S-100 protein and Ki-67. In addition, we used the western blot method to investigate immunohistochemical-affinity in adipocytes. Mature adipocytes and lipoblasts in all of the benign and malignant lipomatous tumors intensively expressed cell contours positivity for Topo-II alpha. Cytoplasm of the lipoblasts occasionally reacted to the antibody and highlighted intracytoplasmic small unilocular, multivacuolated, or bubble-like patterns. Western blot analysis confirmed a 70 kDa product reactive to Topo-II alpha in the cell membrane fragment of mature adipocytes. S-100 protein expressed adipocytes and lipoblasts, but the detection of lipoblasts was not as easy as in Topo-II alpha immunostaining. Immunoreactivity of Ki-67 was limited to the nuclei, and the nuclear labeling index of Ki-67 correlated with that of Topo-II alpha. The immunoreactivity of Topo-II alpha for lipoblasts was more sensitive and obvious than those of S-100 protein. Immunostaining using the antibody for Topo-II alpha seems to be useful in recognizing lipoblasts that have been overlooked in hematoxylin-eosin-stained preparations, and is a useful marker for diagnosing liposarcoma.


Gastric inverted hyperplastic polyp. Report of four cases and relation to gastritis cystica profunda

Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by downward growth of the hyperplastic mucosal components into the submucosa. To the best ofour knowledge, 16 gastric IHP cases have been described in the English literature, but the pathogenesis has not been established. We report the clinical and pathological findings of four gastric IHP cases. The lesions were mainly composed of hyperplastic foveolar-type glands with focal cystic dilatation. Pyloric type glands, endocrine cells, acinic cell metaplasia, and smooth muscle bundles were also seen as components of the polyp. Two cases (cases 1 and 4) coexisted with multifocal gastritis cystica profunda (GCP) and gastric adenocarcinoma. Case 4 furthermore exhibited an intermediate form between IHP and GCP. We suggest that IHP may be GCP associated with exaggeratedly hyperplastic and metaplastic changes. In case 4, the coexisting gastric carcinoma was mainly located in the submucosa, whilst the mucosal component was minimal. Five out of twenty reported gastric IHP cases, including our cases, coexisted with gastric adenocarcinoma. These facts would lead us to further investigate the relation between gastric IHP and carcinoma.


二次的変性を伴った側頭骨軟骨芽細胞腫の1例

二次的変性を伴った側頭骨軟骨芽細胞腫の1例


Diff-Quik染色が診断に有用であった卵巣好酸性明細胞腺癌の1例

Diff-Quik染色が診断に有用であった卵巣好酸性明細胞腺癌の1例


偽血管腔がみられなかった血管腫様悪性線維組織球腫の1例

偽血管腔がみられなかった血管腫様悪性線維組織球腫の1例


Ruptured Right Deep Femoral Aneurysm Concomitant with Aneurysm of Left Lateral Femoral Circumflex Artery

左外側大腿回旋動脈瘤を伴う右破裂性大腿深動脈瘤の1例

日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery


Two cases of allergic fungal rhinosinusitis

当院で経験したアレルギー性真菌性鼻副鼻腔炎例

Tokushima Red Cross Hospital Medical Journal


A case of pulmonary intravascular large B-cell lymphoma evaluated by 18 F-FDG-PET/CT

18 F-FDG-PET/CT検査が病期診断と治療効果判定に有用であった肺血管内リンパ腫の1症例


Verrucous carcinoma presenting with a histopathological variety : A case report

多彩な病理所見を呈し診断に苦慮したverrucous carcinoma の1例


A case of choriocarcinoma developed four years after normal delivery

正常妊娠後4年で発症した絨毛癌肺転移の1例


Cytomegalovirus-associated gastric ulcers complicated by virus-associated hemophagocytic syndrome in a patient with rheumatoid arthritis under prolonged immunosuppression

関節リウマチに対するメトトレキサート治療中に サイトメガロウイルス胃潰瘍および血球貪食症候群を来した1例


Improving Turn-around Time(TAT)-A Fundamental Performance Analysis of Nanopia P-FDP & Nanopia D-dimer on the CS-2000 i

TAT(Turnaround Time)を考慮したCS‐2000i による ナノピアP-FDP・ナノピアDD 試薬の基礎検討


An ISO9001 based trial in the Department of Clinical Laboratory : Utilization and staff participation pertaining to the use of electronic medical record terminals

検査部におけるISO9001をもとにした取り組み∼電子カルテ端末を利用した情報見える化・職員参画∼


Elevation of serum chloride due to continuous use of nonprescription sedatives : A case report

市販鎮痛薬の長期服用により偽性高クロール血症を認めた1例


A case of primary effusion lymphoma detected in the pericardial effusion of a HIV and HHV-8 negative patient

HIV陰性 HHV‐8陰性患者の心嚢液に発生した原発性浸出液リンパ腫の1例


A case of posterior reversible encephalopathy syndrome complicated by Epstein-Barr virus-hemophagocytic lymphohistiocytosis

治療中，posterior reversible encephalopathy syndrome(PRES)を合併した EB ウイルス関連血球貪食症候群の1例


A case of carcinosarcoma of the uterine cervix


局所的な大動脈解離による外傷性大動脈閉鎖不全症に対する1手術例

局所的な大動脈解離による外傷性大動脈閉鎖不全症に対する1手術例


切除術より20年後に再発した足部の筋血管周皮腫の1例

切除術より20年後に再発した足部の筋血管周皮腫の1例


Epstein-Barr virus-positive gastric cancer with lymph node metastasis : a case report


長期間自然経過を追えた早期肺癌の1例

長期間自然経過を追えた早期肺癌の1例


A Case of Destructive Thyroiditis Presenting with a Clinical Course Similar to Adult-onset Still's Disease

成人スティル病様の臨床経過を示し， 破壊性甲状腺炎を合併した1例


An Autopsy Case of Necrotizing Fasciitis Caused by Vibrio vulnificus


A Case of False High Value of D-dimer Assumed to be a Nonspecific Reaction to Patient IgA

D ダイマー偽高値の原因が患者血漿中のIgA と考えられた1症例


An Autopsy Case of Large Cell Appendiceal Neuroendocrine Carcinoma

病理解剖にて虫垂原発神経内分泌細胞癌・大細胞型と判明した1例


An operative case of constrictive pericarditis with a pericardial cyst

収縮性心膜炎に心膜嚢腫を合併した心不全症例に対する手術経験

Tokushima Red Cross Hospital Medical Journal


深達度sm でリンパ節転移を認めた直腸悪性黒色腫の1例

深達度sm でリンパ節転移を認めた直腸悪性黒色腫の1例


Two cases of Ofuji papuloerythroderma associated with malignant tumor

内臓悪性腫瘍を合併した丘疹‐紅皮症(太藤)の2例


Rapidly growing sublingual schwannoma : A case report

急速に増大した舌下部神経鞘腫の1例


A case of leiomyosarcoma arisen from the right thrombotic phlebitis

右下肢静脈血栓症で発症した平滑筋肉腫の1例


Cerebral Yolk Sac Tumor in a 14-year-old Boy Undergoing Primary High-dose Chemotherapy with Autologous Peripheral Stem Cell Rescue

1st line で自家末梢血幹細胞移植を施行した 頭蓋内胚細胞性腫瘍(Yolk sac tumor)の1例


A Very Rare Case of Gastric Mesenchymal Tumor Treated by Pyloric Ring-preserving Laparoscopic Distal Gastrectomy

幽門輪温存腹腔鏡下幽門側胃切除を行った極めてまれな胃間葉系腫瘍の1例

徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal


A Case of IgG4-related Disease that Developed 10Years after Onset of Type2 Diabetes Mellitus

2型糖尿病発症から10年を経て発症したIgG4関連疾患の1例


A case of a low-differentiated adenocarcinoma in the transverse colon involving a neuroendocrine component

神経内分泌成分を含む横行結腸低分化腺癌の1例


Two Cases of alpha-Fetoprotein-Producing Gastric Cancer Responding Well to Preoperative Chemotherapy

術前化学療法が奏効したAFP産生胃癌の2例


Near-drowning of a 34-Year-Old Woman Apparently Due to Cardiogenic Cardiac Arrest : A Case Report

心原性心停止が原因と考えられた34歳女性の溺水例


A Case of Metachronous Triple Cancers, Developing Descending Colon Cancer and alpha-Fetoprotein-Producing Gastric Cancer after Surgery for Lung Cancer That was Treated with Laparoscopic Surgery

肺癌術後に発症し，鏡視下手術を行った下行結腸癌，AFP産生胃癌の異時性3重複癌の1例


A Case of Lipoid Pneumonia That was Difficult to Diagnose

診断に苦慮したリポイド肺炎の1例


Disseminated Trichosporonosis in Patients with Hematological Malignancies : Analysis of Two Autopsy Cases

播種性トリコスポロン症を来した造血器腫瘍患者の2剖検例


Two cases of Dyphyllobothrium nihonkaiense infection


Anaplastic Astrocytoma Appearing 7 Years After Cranial Radiotherapy for Acute Lymphocytic Leukemia

急性リンパ性白血病治療終了後から7年後に発症した anaplastic astrocytoma の1例


A Case of Autoimmune Pancreatitis Occurring with Mikulicz's Disease

ミクリッツ病診断を契機に発見された自己免疫性膵炎の1症例 中

Tokushima Red Cross Hospital Medical Journal


Experience with Lower Lip Reconstruction Using Advancement Flaps from the Cutaneous and Mucosal Sides

皮膚側と粘膜側からの前進皮弁による下口唇再建の経験


A Case of Chylous ascites Seemingly Attributable to Collapse of Lymphangioma

卵巣リンパ管腫の破たんによると思われた乳び様腹水の1症例


高齢者に発症した皮膚腺病の1例


A Case of Xanthogranulomatous Pyelonephritis Complicated by Colonic Perforation Five Days after Nephrectomy

腎摘後5日目に結腸穿孔を生じた黄色肉芽腫性腎盂腎炎の1例


A Case of Non-Hodgkin Lymphoma Presenting with Spontaneous Splenic Rupture

非外傷性脾破裂にて発見された悪性リンパ腫の1例


An Autopsied Case of Primary Central Nervous System Lymphomas Difficult to Distinguish from Glioblastoma

膠芽腫との鑑別が困難であった脳原発悪性リンパ腫の1解剖例


A Case of Acute Generalized Exanthematous Pustulosis due to Ampicillin

アンピシリンによる acute generalized exanthematous pustulosis の1例


A Sporadic Marfan Syndrome Diagnosed with Appearance of Heart Failure

心不全を契機に発見された孤発性マルファン症候群の1例


A Case of Premalignant Fibroepithelial Tumor


Spontaneous Renal Pelvic Rupture Caused by Ureteral Cancer : A Case Report

腎盂自然破裂をきたした左尿管癌の1例


【内分泌病理学最近の進歩2002】副腎髄質と傍神経節から同時発生した小児褐色細胞腫


Quality of skeletal muscles during allogeneic stem-cell transplantation: a pilot study


Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides


Cutaneous T-cell lymphoma developing during nivolumab treatment for metastatic melanoma.


Capillary leak syndrome: initial presentation in a patient with ALK+anaplastic large cell lymphoma associated with increased levels of serum cytokines.