published_papers "タイトル(日本語)","タイトル(英語)","著者(日本語)","著者(英語)","担当区分","概要(日本語)","概要(英語)","出版者・発行元(日本語)","出版者・発行元(英語)","出版年月","誌名(日本語)","誌名(英語)","巻","号","開始ページ","終了ページ","記述言語","査読の有無","招待の有無","掲載種別","国際・国内誌","国際共著","DOI","ISSN","eISSN","URL","URL2","主要な業績かどうか","公開の有無" "Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis","Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis","Takaharu Goto, Takahiro Kishimoto, Shinji Fujiwara, Yasuhiko Shirayama, Tetsuo Ichikawa","Takaharu Goto, Takahiro Kishimoto, Shinji Fujiwara, Yasuhiko Shirayama, Tetsuo Ichikawa","null","null","null","null","null","2024-02","Scientific Reports","Scientific Reports","Vol.14","No.1","3410","3410","eng","true","null","scientific_journal","null","null","null","2045-2322","null","null","null","null","null" "Stress Reduction Effects during Block-Tapping Task of Jaw in Healthy Participants: Functional Near-Infrared Spectroscopy (fNIRS) Measurements of Prefrontal Cortex Activity","Stress Reduction Effects during Block-Tapping Task of Jaw in Healthy Participants: Functional Near-Infrared Spectroscopy (fNIRS) Measurements of Prefrontal Cortex Activity","Takahiro Kishimoto, Takaharu Goto, Tetsuo Ichikawa","Takahiro Kishimoto, Takaharu Goto, Tetsuo Ichikawa","null","The purpose of this study was to explore the influence of simple jaw opening and closing task of chewing movements on the activities of the prefrontal cortex (PFC) from the viewpoint of stress reduction. We measured cerebral blood flow (CBF) in the PFC during a block-tapping task of the jaw in healthy participants. Eleven young healthy individuals with normal dentition (7 males and 4 females, mean age 28.0 ± 3.7 years) volunteered for this study. CBF was measured using a wearable, functional near-infrared spectroscopy device. Measurements were taken using the central incisors and first molars at interocclusal distances of 5 and 10 mm. The participants were asked to bite a hard/soft block. CBF in all conditions showed limited variability or decreasing trend compared to resting state before the task. The main effect was observed for interocclusal distance ( = 0.008), and there were no significant differences for measurement area of the PFC, tooth type, and material type. An interaction was found between tooth type and material type. In conclusion, these results suggest that simple and rhythmical chewing motion has an effect of reducing CBF in the PFC and resting the PFC, which is an especially notable aspect of periodontal sensory information in the molar.","The purpose of this study was to explore the influence of simple jaw opening and closing task of chewing movements on the activities of the prefrontal cortex (PFC) from the viewpoint of stress reduction. We measured cerebral blood flow (CBF) in the PFC during a block-tapping task of the jaw in healthy participants. Eleven young healthy individuals with normal dentition (7 males and 4 females, mean age 28.0 ± 3.7 years) volunteered for this study. CBF was measured using a wearable, functional near-infrared spectroscopy device. Measurements were taken using the central incisors and first molars at interocclusal distances of 5 and 10 mm. The participants were asked to bite a hard/soft block. CBF in all conditions showed limited variability or decreasing trend compared to resting state before the task. The main effect was observed for interocclusal distance ( = 0.008), and there were no significant differences for measurement area of the PFC, tooth type, and material type. An interaction was found between tooth type and material type. In conclusion, these results suggest that simple and rhythmical chewing motion has an effect of reducing CBF in the PFC and resting the PFC, which is an especially notable aspect of periodontal sensory information in the molar.","null","null","2022-12-14","Brain Sciences","Brain Sciences","Vol.12","No.12","1711","1711","eng","true","null","scientific_journal","null","null","10.3390/brainsci12121711","2076-3425","null","null","null","null","null" "Does Prosthodontic Treatment Improve the Nutrition Status in the Elderly? Literature Review","Does Prosthodontic Treatment Improve the Nutrition Status in the Elderly? Literature Review","Tetsuo Ichikawa, Takaharu Goto, Takahiro Kishimoto, Yuichi Ishida, Megumi Watanabe","Tetsuo Ichikawa, Takaharu Goto, Takahiro Kishimoto, Yuichi Ishida, Megumi Watanabe","null","null","null","null","null","2022-01","Journal of Food and Nutrition Research","Journal of Food and Nutrition Research","Vol.10","No.1","26","31","eng","true","null","scientific_journal","null","null","10.12691/jfnr-10-1-4","2333-1119","null","null","null","null","null" "高齢者におけるATP拭き取り検査による口腔衛生状態不良の客観的評価","Objective Assessment of Poor Oral Hygiene Using the ATP Swab Test in the Elderly","藤本 けい子, 岩脇 有軌, 後藤 崇晴, 岸本 卓大, 永尾 寛, 市川 哲雄","Keiko Fujimoto, Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Kan Nagao, Tetsuo Ichikawa","null","
目的:ATP拭き取り検査キットを用いた口腔衛生状態不良の評価方法について,口腔機能低下症で示された評価法と比較し検討することを目的とした.
方法:2019年10月から2020年4月までの間に徳島大学病院歯科にてメンテナンスを行っている高齢者102名に対し,残存歯数の測定および口腔衛生状態不良の検査を行った.口腔衛生状態不良の検査では,舌苔付着度(Tongue Coating Index,TCI),細菌数測定装置による細菌数測定,およびATP拭き取り検査キットによるATP+AMP量の測定を行った.被検体は来院時すぐに10 mLの水で5秒間含嗽を行って吐き出した含嗽溶液と綿棒で舌背部を拭ったものとした.また,口腔内の衛生状態の包括評価として,5段階で口腔粘膜および義歯の主観的評価を行った.
結果:舌背部の測定に関して,ATP拭き取り検査値とTCIにおけるSpearmanの順位相関係数は0.374(p<0.001),TCIと細菌数における相関係数は0.429(p<0.001),細菌数とATP拭き取り検査値における相関係数は0.388(p<0.001)であった.また,包括評価に関して,口腔粘膜の衛生状態とATP拭き取り検査(舌背部),ATP拭き取り検査(含嗽溶液),TCI,細菌数(含嗽溶液)との相関係数はそれぞれ-0.257(p=0.009),-0.274(p=0.005),-0.209(p=0.035),-0.321(p=0.001)であった.義歯の衛生状態とATP拭き取り検査値(含嗽溶液),TCIとの相関係数はそれぞれ-0.317(p=0.001),-0.232(p=0.019)であった.
結論:ATP拭き取り検査キットによる測定は,食物残渣などを含む総合的な口腔衛生状態不良を客観的に評価できる可能性が示唆された.
","Purpose:The purpose of this study was to evaluate the assessment of poor oral hygiene using the ATP swab test.
Method:A total of 102 consecutive elderly outpatients aged ≥65 years who visited for maintenance were enrolled between October 2019 and April 2020. The evaluation of poor oral hygiene included measurements of:Tongue Coating Index(TCI), number of bacteria by a rapid oral bacterial detection device(Bacterial Counter DU-AA01NP-H;Panasonic Health Care, Japan), and amount of ATP+AMP by the ATP swab test(Lumitester;Kikkoman, Japan). The specimens were a gargle solution rinsed with 10 mL of water for 5 seconds as soon as the patients came to the hospital or a cotton swab wiped on the tongue dorsum. The subjective assessment of hygiene of the oral mucosa and dentures was rated on a 5-point scale.
Results:In the assessment of tongue dorsum hygiene, the number of bacteria and the amount of ATP+AMP were significantly correlated with TCI. There was also a significant correlation between the number of bacteria and the amount of ATP+AMP.
Conclusion:The results of this study suggested that the ATP swab test might be used to objectively assess overall poor oral hygiene, including food residues.
","null","null","2021-06","老年歯科医学","Japanese Journal of Gerodontology","Vol.36","No.1","44","52","jpn","true","null","scientific_journal","null","null","10.11259/jsg.36.44","0914-3866","null","https://ci.nii.ac.jp/naid/130008065909/","null","null","null" "Reliability of screening methods to diagnose oral dryness and evaluate saliva secretion","Reliability of screening methods to diagnose oral dryness and evaluate saliva secretion","Takaharu Goto, Takahiro Kishimoto, Yuki Iwawaki, Keiko Fujimoto, Yuichi Ishida, Megumi Watanabe, Kan Nagao, Tetsuo Ichikawa","Takaharu Goto, Takahiro Kishimoto, Yuki Iwawaki, Keiko Fujimoto, Yuichi Ishida, Megumi Watanabe, Kan Nagao, Tetsuo Ichikawa","null","null","null","null","null","2020-09","Dentistry Journal","Dentistry Journal","Vol.8","No.3","null","null","eng","true","null","scientific_journal","null","null","10.3390/dj8030102","2304-6767","null","null","null","null","null" "Does periodontal tactile input uniquely increase cerebral blood flow in the prefrontal cortex?","Does periodontal tactile input uniquely increase cerebral blood flow in the prefrontal cortex?","Takaharu Goto, Nobuaki Higaki, Takahiro Kishimoto, Yoritoki Tomotake, Tetsuo Ichikawa","Takaharu Goto, Nobuaki Higaki, Takahiro Kishimoto, Yoritoki Tomotake, Tetsuo Ichikawa","null","We previously studied the effect of peripheral sensory information from sensory periodontal ligament receptors on prefrontal cortex (PFC) activity. In the dental field, an alternative dental implant without periodontal sensation can be applied for missing teeth. In this study, we examine whether periodontal tactile input could increase cerebral blood flow (CBF) in the PFC against elderly patients with dental implants lacking periodontal tactile (implant group), elderly individuals with natural teeth (elderly group), and young individuals with natural teeth (young group). The experimental task of maintaining occlusal force as closed-loop stimulation was performed. Compared with the young group, the elderly group showed significantly lower CBF. Contrastingly, compared with the young group, the implant group showed significantly lower CBF. There were no significant differences between the elderly and implant groups. Regarding the mean occlusal force value, compared with the young group and the elderly group, the implant group had a numerically, but not significantly, larger occlusal force exceeding the directed range. In conclusion, the periodontal tactile input does not uniquely increase PFC activity. However, increased CBF in the PFC due to the periodontal tactile input in the posterior region requires existing attention behavior function in the PFC.","We previously studied the effect of peripheral sensory information from sensory periodontal ligament receptors on prefrontal cortex (PFC) activity. In the dental field, an alternative dental implant without periodontal sensation can be applied for missing teeth. In this study, we examine whether periodontal tactile input could increase cerebral blood flow (CBF) in the PFC against elderly patients with dental implants lacking periodontal tactile (implant group), elderly individuals with natural teeth (elderly group), and young individuals with natural teeth (young group). The experimental task of maintaining occlusal force as closed-loop stimulation was performed. Compared with the young group, the elderly group showed significantly lower CBF. Contrastingly, compared with the young group, the implant group showed significantly lower CBF. There were no significant differences between the elderly and implant groups. Regarding the mean occlusal force value, compared with the young group and the elderly group, the implant group had a numerically, but not significantly, larger occlusal force exceeding the directed range. In conclusion, the periodontal tactile input does not uniquely increase PFC activity. However, increased CBF in the PFC due to the periodontal tactile input in the posterior region requires existing attention behavior function in the PFC.","null","null","2020-07-26","Brain Sciences","Brain Sciences","Vol.10","No.8","E482","E482","eng","true","null","scientific_journal","null","null","10.3390/brainsci10080482","2076-3425","null","null","null","null","null" "アルコール含有義歯安定剤であるホームリライナーが呼気中アルコール濃度へ与える影響の評価","アルコール含有義歯安定剤であるホームリライナーが呼気中アルコール濃度へ与える影響の評価","岩脇 有軌, 後藤 崇晴, 岸本 卓大, 南 憲一, 藤本 けい子, 市川 哲雄","Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Norikazu Minami, Keiko Fujimoto, Tetsuo Ichikawa","null","null","null","null","null","2019-10","日本補綴歯科学会誌","Annals of Japan Prosthodontic Society","Vol.11","No.4","376","382","jpn","true","null","scientific_journal","null","null","10.2186/ajps.11.376","1883-6860","null","null","null","null","null" "Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal force","Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal force","Takahiro Kishimoto, Takaharu Goto, Tetsuo Ichikawa","Takahiro Kishimoto, Takaharu Goto, Tetsuo Ichikawa","null","The prefrontal cortex (PFC) plays an important role in several cognitive functions, such as planning, decision making, and social behavior. We previously reported that periodontal sensory input significantly increases PFC activity during the motor task of maintaining occlusal (biting) force. However, the relationships between periodontal sensation, PFC activity, and the performance of motor tasks have not been evaluated in detail. Therefore, using functional near-infrared spectroscopy, we investigated PFC activity by monitoring changes in cerebral blood flow (CBF) to specific areas of the PFC that corresponded to changes in occlusal force generated during four different biting tasks: (1) occlusion with the central incisor with an interocclusal distance of 5 mm (BI-5 mm); or (2) 10 mm (BI-10 mm); (3) occlusion with the first molars with an interocclusal distance of 5 mm (BM-5 mm), or (4) 10 mm (BM-10 mm). Occlusion of molars generated increased PFC regional CBF as the interocclusal distance decreased (BM-10 mm vs BM-5 mm). No significant differences in CBF during occlusion of incisors were found when comparing 5 mm and 10 mm intercostal distances (BI-5 mm vs BI-10 mm). The mean occlusal force generated by BM-5 mm occlusion was significantly lower than that generated by BM-10 mm occlusion. Taken together, our results suggest that the PFC decreases efferent signaling to motor units, to reduce occlusal force generated when periodontal sensation, which is greater when the interocclusal distance is reduced, is primarily responsible for maintaining occlusal force in the absence of sensations from the temporomandibular joint and muscle spindles.","The prefrontal cortex (PFC) plays an important role in several cognitive functions, such as planning, decision making, and social behavior. We previously reported that periodontal sensory input significantly increases PFC activity during the motor task of maintaining occlusal (biting) force. However, the relationships between periodontal sensation, PFC activity, and the performance of motor tasks have not been evaluated in detail. Therefore, using functional near-infrared spectroscopy, we investigated PFC activity by monitoring changes in cerebral blood flow (CBF) to specific areas of the PFC that corresponded to changes in occlusal force generated during four different biting tasks: (1) occlusion with the central incisor with an interocclusal distance of 5 mm (BI-5 mm); or (2) 10 mm (BI-10 mm); (3) occlusion with the first molars with an interocclusal distance of 5 mm (BM-5 mm), or (4) 10 mm (BM-10 mm). Occlusion of molars generated increased PFC regional CBF as the interocclusal distance decreased (BM-10 mm vs BM-5 mm). No significant differences in CBF during occlusion of incisors were found when comparing 5 mm and 10 mm intercostal distances (BI-5 mm vs BI-10 mm). The mean occlusal force generated by BM-5 mm occlusion was significantly lower than that generated by BM-10 mm occlusion. Taken together, our results suggest that the PFC decreases efferent signaling to motor units, to reduce occlusal force generated when periodontal sensation, which is greater when the interocclusal distance is reduced, is primarily responsible for maintaining occlusal force in the absence of sensations from the temporomandibular joint and muscle spindles.","null","null","2019-10","Experimental Brain Research","Experimental Brain Research","Vol.237","No.11","2767","2774","eng","true","null","scientific_journal","null","null","10.1007/s00221-019-05630-y","1432-1106","null","null","null","null","null" "Comparison between two assessment tests for oral hygiene: adenosine triphosphate + adenosine monophosphate swab test and bacteria number counting by dielectrophoretic impedance measurement","Comparison between two assessment tests for oral hygiene: adenosine triphosphate + adenosine monophosphate swab test and bacteria number counting by dielectrophoretic impedance measurement","Yuki Iwawaki, Muraoka Yuki, Higashiyama Hiroaki, Takahiro Kishimoto, Liu Lipei, Takaharu Goto, Tetsuo Ichikawa","Yuki Iwawaki, Muraoka Yuki, Higashiyama Hiroaki, Takahiro Kishimoto, Liu Lipei, Takaharu Goto, Tetsuo Ichikawa","null","null","null","null","null","2019-02","Dentistry Journal","Dentistry Journal","Vol.7","No.1","10","10","eng","true","null","scientific_journal","null","null","10.3390/dj7010010","2304-6767","null","null","null","null","null" "日本の歯科学生とインドネシアの歯科学生・歯科衛生士学生における放射線に対する理解度とリスク認識との関係","日本の歯科学生とインドネシアの歯科学生・歯科衛生士学生における放射線に対する理解度とリスク認識との関係","吉田 みどり, リナ ドゥイ ヤヌアリスカ, ルリ ラトナ シャンティニングシー, 吉原 穂積, 岸本 卓大, 前田 直樹, 細木 秀彦, ムジョセメディ ムナクヒル, 誉田 栄一","Midori Yoshida, リナ ドゥイ ヤヌアリスカ, ルリ ラトナ シャンティニングシー, Hozumi Yoshihara, Takahiro Kishimoto, Naoki Maeda, Hidehiko Hosoki, ムジョセメディ ムナクヒル, Eiichi Honda","null","null","null","null","null","2021-05","歯科放射線","Dental Radiology","Vol.61","null","75","75","jpn","null","null","research_institution","null","null","null","0389-9705","null","null","null","null","null"