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en: Psychogenic Nonepileptic Seizures Following Orthognathic Surgery: A Case Report

en: Oral Science International

ja: Oral Science International


en: Application and evaluation of carbonate apatite granules for mandibular bone defect reconstruction after jawbone cyst enucleation-a retrospective case series

en: To evaluate the effectiveness of COAp granules in the mandibular bone defects by using computed tomography (CT) images. This study was retrospective case series of mandibular bone defect reconstruction using COAp granules. Six patients with jawbone cysts treated by simultaneous grafting COAp granules after cyst enucleation were enrolled. Patients without grafting COAp granules were excluded. Mandibular bone height including buccolingual bone height, the change of perpendicular distance between the buccolingual line to the alveolar ridge, and the three-dimensional volume of remaining COAp granules were analyzed using CT images obtained at 3, 6, 12, 18, and 24 months postoperatively. Postoperative CT images showed that cortical and cancellous bone-like structures were formed on the grafting area periphery and inside the defect, respectively, with gradual resorption of the COAp granules. Furthermore, there was no evidence of leaving bone defect even at the center of the lesion when the defect was successfully reconstructed by filling it with COAp granules. The percentage volume of remaining COAp granules to the volume at 3 months postoperatively were 76.1 ± 13.1%, 35.8 ± 22.5%, 25.0 ± 13.0%, and 9.9 ± 6.4% at 6, 12, 18, and 24 months postoperatively, and the volume reduction rate increased significantly within 12 months postoperatively. Grafting COAp granules after the enucleation of a jawbone cyst is a good reconstructive treatment option for postoperative prosthetic treatment because COAp granules are gradually replaced by new bone while preserving the contour of the mandibular bone. Not applicable.

en: Oral and Maxillofacial Surgery

ja: Oral and Maxillofacial Surgery


en: Fabrication of a carbonate apatite granules sponge as a new bone substitute and its histological evaluation at rat calvarial bone defects

en: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology


en: Comparison of bioresorbable bone substitutes, carbonate apatite and β-tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement.


en: Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure.

en: Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone.

en: Journal of Materials Science. Materials in Medicine