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en: Fabrication and evaluation of carbonate apatite granule sponges using sh-derived collagen for advanced synthetic bone substitutes

en: Journal of Materials Science. Materials in Medicine


en: 超選択的動脈塞栓術を併用して治療した上顎中心性巨細胞肉芽腫の1例

ja: 超選択的動脈塞栓術を併用して治療した上顎中心性巨細胞肉芽腫の1例

en: Journal of Japan Society for Oral Tumors

ja: 日本口腔腫瘍学会誌


en: Application and evaluation of carbonate apatite granules for mandibular bone defect reconstruction after jawbone cyst enucleation-a retrospective case series

en: To evaluate the effectiveness of COAp granules in the mandibular bone defects by using computed tomography (CT) images. This study was retrospective case series of mandibular bone defect reconstruction using COAp granules. Six patients with jawbone cysts treated by simultaneous grafting COAp granules after cyst enucleation were enrolled. Patients without grafting COAp granules were excluded. Mandibular bone height including buccolingual bone height, the change of perpendicular distance between the buccolingual line to the alveolar ridge, and the three-dimensional volume of remaining COAp granules were analyzed using CT images obtained at 3, 6, 12, 18, and 24 months postoperatively. Postoperative CT images showed that cortical and cancellous bone-like structures were formed on the grafting area periphery and inside the defect, respectively, with gradual resorption of the COAp granules. Furthermore, there was no evidence of leaving bone defect even at the center of the lesion when the defect was successfully reconstructed by filling it with COAp granules. The percentage volume of remaining COAp granules to the volume at 3 months postoperatively were 76.1 ± 13.1%, 35.8 ± 22.5%, 25.0 ± 13.0%, and 9.9 ± 6.4% at 6, 12, 18, and 24 months postoperatively, and the volume reduction rate increased significantly within 12 months postoperatively. Grafting COAp granules after the enucleation of a jawbone cyst is a good reconstructive treatment option for postoperative prosthetic treatment because COAp granules are gradually replaced by new bone while preserving the contour of the mandibular bone. Not applicable.

en: Oral and Maxillofacial Surgery

ja: Oral and Maxillofacial Surgery


en: Fabrication of a carbonate apatite granules sponge as a new bone substitute and its histological evaluation at rat calvarial bone defects

en: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology


en: A case of fishbone in the tongue that migrated toward the hyoid bone

ja: 舌骨近傍に移動した舌内迷入魚骨の1例

en: Japanese Journal of Oral & Maxillofacial Surgery

ja: 日本口腔外科学会雑誌


en: Computed tomography-based morphological analysis for intraoral vertical ramus osteotomy in patients with mandibular prognathism

en: Oral Science International

ja: Oral Science International


en: Comparison of bioresorbable bone substitutes, carbonate apatite and β-tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement.


en: Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure.

en: Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone.

ja: Journal of Materials Science. Materials in Medicine


en: Survey of oral maxillofacial injury experiences and sports mouthguard use in wakeboarders

en: International Journal of Sports Dentistry


en: ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討

ja: ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討

en: Oral Care

ja: 日本口腔ケア学会雑誌


en: Association of PD L1 and ZEB 1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma

en: Programmed cell death-1 (PD-1) and its ligand programmed cell death 1 ligand 1 (PD-L1) are immune checkpoint inhibitors that play an important role in the host immune avoidance mechanism of tumors. The relationship between PD-L1 expression and malignancy has been reported in various types of cancer, such as lung and gastric cancer. In addition, epithelial-mesenchymal transition (EMT) of cancer cells is deeply involved in the invasion and metastasis of cancer. It has been reported that zinc finger E-box binding homeobox 1 (ZEB-1), an EMT inducer, contributes to metastasis in pancreatic and colon cancer. The present study aimed to investigate the relationship between the expression patterns of two markers, PD-L1 and ZEB-1, and clinicopathological characteristics and prognosis of oral squamous cell carcinoma (OSCC). Biopsy or surgical excision specimens from 169 patients with OSCC were used in the present study. Immunohistochemical staining with monoclonal anti-PD-L1 antibody and anti-ZEB-1 antibody was conducted. Cases with >1% tumor cells positive for PD-L1 and those with >10% tumor cells positive for ZEB-1 were considered positive, respectively. The findings revealed that individual expression of PD-L1 and ZEB-1 in OSCC was not associated with tumor size, degree of differentiation or Yamamoto-Kohama invasion pattern classification. However, co-expression of PD-L1 and ZEB-1 was associated with higher cervical lymph node metastasis and a lower survival rate. In conclusion, the results of the present study indicated that co-expression of PD-L1 and ZEB-1 could serve as a potential marker for the prognosis of patients with OSCC.

en: Oncology Letters

ja: Oncology Letters


en: Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

en: Carbonate apatite (CO Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO Ap granules through a two-step dissolution-precipitation reaction using CaSO as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO Ap. Porous CO Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO Ap (120) [porous CO Ap granules made using 120-μm microfiber] followed by CO Ap (50) and CO Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO Ap (120). It is concluded, therefore, that the optimal pore size of the CO Ap is that of CO Ap (120), which is 85 μm.

en: Journal of Biomedical Materials Research. Part A