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徳島大学先端酵素学研究所基幹研究部門
徳島大学薬科学教育部創薬科学専攻
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研究活動

個人のホームページ

専門分野

ライフサイエンス (Life sciences) [機能生物化学 (Functional biochemistry)]
ライフサイエンス (Life sciences) [生物有機化学 (Bioorganic chemistry)]

研究テーマ

著書・論文

学術論文(審査論文):

1. Yoshinobu Fujiwara, Takeshi Ito, Atsumi Toiyama, Takenori Yamamoto, Naoshi Yamazaki, Mitsuru Shindo and Yasuo Shinohara :
Suramin Inhibits Mitochondrial ADP/ATP Carrier, Not Only from the Cytosolic Side But Also from the Matrix Side, of the Mitochondrial Inner Membrane,
BPB Reports, Vol.4, No.3, 92-97, 2021.
(DOI: 10.1248/bpbreports.4.3_92,   CiNii: 130008053512)
2. Leonor García-Bayona, J Michael Coyne, Noam Hantman, Paula Montero-Llopis, S Salena Von, Takeshi Ito, H Michael Malamy, Marek Basler, Blanca Barquera and E Laurie Comstock :
Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts,
Proceedings of the National Academy of Sciences of the United States of America, Vol.117, No.39, 24484-24493, 2020.
(DOI: 10.1073/pnas.2009556117,   PubMed: 32938803)
3. Takahiro Masuya, Yuki Sano, Hinako Tanaka, L Nicole Butler, Takeshi Ito, Tatsuhiko Tosaki, E Joel Morgan, Masatoshi Murai, Blanca Barquera and Hideto Miyoshi :
Inhibitors of a Na +-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function,
The Journal of Biological Chemistry, Vol.295, No.36, 12739-12754, 2020.
(DOI: 10.1074/jbc.RA120.014229,   PubMed: 32690607)
4. Takeshi Ito, Rene Gallegos, M Leigh Matano, L Nicole Butler, Noam Hantman, Matthew Kaili, J Michael Coyne, E Laurie Comstock, H Michael Malamy and Blanca Barquera :
Genetic and Biochemical Analysis of Anaerobic Respiration in Bacteroides fragilis and Its Importance In Vivo,
mBio, Vol.11, No.1, 2020.
(DOI: 10.1128/mBio.03238-19,   PubMed: 32019804)
5. Adam Maynard, L Nicole Butler, Takeshi Ito, José Silva Adilson da, Masatoshi Murai, Tsute Chen, G Mattheos A Koffas, Hideto Miyoshi and Blanca Barquera :
Antibiotic Korormicin A Kills Bacteria by Producing Reactive Oxygen Species,
Journal of Bacteriology, Vol.201, No.11, 2019.
(DOI: 10.1128/JB.00718-18,   PubMed: 30858300)
6. Takahiro Masuya, Masatoshi Murai, Takeshi Ito, Shunsuke Aburaya, Wataru Aoki and Hideto Miyoshi :
Pinpoint Chemical Modification of the Quinone-Access Channel of Mitochondrial Complex I via a Two-Step Conjugation Reaction,
Biochemistry, Vol.56, No.32, 4279-4287, 2017.
(DOI: 10.1021/acs.biochem.7b00612,   PubMed: 28707880)
7. Takeshi Ito, Masatoshi Murai, Satoshi Ninokura, Yuki Kitazumi, G Katherine Mezic, F Brady Cress, G Mattheos A Koffas, E Joel Morgan, Blanca Barquera and Hideto Miyoshi :
Identification of the binding sites for ubiquinone and inhibitors in the Na +-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling,
The Journal of Biological Chemistry, Vol.292, No.19, 7727-7742, 2017.
(DOI: 10.1074/jbc.M117.781393,   PubMed: 28298441)
8. Takeshi Ito, Masatoshi Murai, Hironobu Morisaka and Hideto Miyoshi :
Identification of the Binding Position of Amilorides in the Quinone Binding Pocket of Mitochondrial Complex I,
Biochemistry, Vol.54, No.23, 3677-3686, 2015.
(DOI: 10.1021/acs.biochem.5b00385,   PubMed: 26009789)
9. Masatoshi Murai, Sonomi Murakami, Takeshi Ito and Hideto Miyoshi :
Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I,
Biochemistry, Vol.54, No.17, 2739-2746, 2015.
(DOI: 10.1021/acs.biochem.5b00187,   PubMed: 25849763)
10. Masatoshi Murai, Sayako Habu, Sonomi Murakami, Takeshi Ito and Hideto Miyoshi :
Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I,
Bioscience, Biotechnology, and Biochemistry, Vol.79, No.7, 1061-1066, 2015.
(DOI: 10.1080/09168451.2015.1010479,   PubMed: 25731956)

国内講演発表:

1. 伊藤 剛 :
腸内細菌Bacteroides fragilisにおける呼吸鎖経路の解明,
高齢化と生体恒常性研究会 第1回交流会, 2021年3月.
2. 伊藤 剛 :
腸内細菌Bacteroides fragilisにおける呼吸鎖経路の解明,
徳島大学薬学部若手教員講演会, 2021年1月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)