m_ishizu/published_papers/52828379 Masayoshi Zaitsu Kazuhiko Watanabe Mako Nagayoshi Hiroaki Ikezaki Takuma Furukawa Yasufumi Kato Yuriko N. Koyanagi Nobuaki Michihata Chihaya Koriyama Sadao Suzuki Daisuke Matsui Kiyonori Kuriki Naoyuki Takashima Masashi Ishizu Itsuki Kageyama Takashi Tamura Kenji Wakai Keitaro Matsuo Educational disparities in mortality mediated by modifiable behavioral factors: Findings from the Japan Multi-Institutional Collaborative Cohort Study Elsevier BV Public Health 0033-3506 252 106142 106142 20260300 10.1016/j.puhe.2026.106142 m_ishizu/published_papers/51848650 Akari Matsuura Takeshi Watanabe Yuka Torii Kahori Kita Taichi Unohara Masashi Ishizu Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Mako Nagayoshi Kenji Wakai Yasufumi Kato Takashi Matsunaga Yuriko N Koyanagi Isao Oze Nobuaki Michihata Yohko Nakamura Chihaya Koriyama Daisaku Nishimoto Sadao Suzuki Takahiro Otani Naoyuki Takashima Etsuko Ozaki Kiyonori Kuriki Naoko Miyagawa Keiko Kondo Takashi Tamura Keitaro Matsuo Nutrient patterns and mortality: results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. BACKGROUND: The consumption of a healthy diet may play an important role in the prevention of noncommunicable diseases (NCDs). Although associations between nutrient patterns and cardiometabolic risk factors or NCDs have been examined, the associations between nutrient patterns and mortality remain unknown. The present study examined the relationships between nutrient patterns and all-cause and cause-specific mortalities in a large Japanese population. METHODS: A prospective cohort analysis was performed on the data of 72,939 participants aged 35-69 years with a mean follow-up of 11.7 years in the Japan Multi-Institutional Collaborative Cohort Study. A factor analysis was applied to the energy-adjusted intakes of 21 nutrients, and 4 nutrient patterns were extracted: Factor 1 (folate, carotene, fiber, vitamin C, potassium, iron, and retinol patterns); Factor 2 (unsaturated fatty acid and vitamin E patterns); Factor 3 (saturated fatty acid, calcium, vitamin B2 and low carbohydrate patterns); and Factor 4 (sodium, protein and vitamin D patterns). A multivariable Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortalities according to the quartiles of nutrient patterns adjusted for potential confounders including age, sex, research site, drinking and smoking habits. RESULTS: During the follow-up period, 3,488 deaths were identified. A higher Factor 1 (folate, carotene, fiber, vitamin C, potassium, iron, and retinol) score was associated with lower all-cause (HR 0.81, 95% CI 0.73-0.90), CVD (HR 0.65, 95% CI 0.49-0.85) and cerebrovascular disease (HR 0.60, 95% CI 0.38-0.96) mortalities. The second lowest quartile group of the Factor 2 (unsaturated fatty acid and vitamin E) score was associated with lower all-cause (HR 0.86, 95% CI 0.79-0.94) and cancer (HR 0.85, 95% CI 0.76-0.95) mortalities. On the other hand, a higher Factor 2 score was associated with greater cerebrovascular disease mortality (HR 1.57, 95% CI 1.03-2.40). CONCLUSIONS: The results of the present study suggest that increased adherence to nutrient patterns rich in folate, carotene, fiber, vitamin C, potassium, iron, and retinol or moderate adherence to unsaturated fatty acids and vitamin E are associated with a decreased risk of mortality in Japanese adults. Nutrition journal null null 20251212 10.1186/s12937-025-01274-7 41382287 m_ishizu/published_papers/51751937 Taichi Unohara Ryosuke Fujii Takeshi Watanabe Akari Matsuura Yuka Torii Kahori Kita Masashi Ishizu Megumi Hara Yuichiro Nishida Mako Nagayoshi Takashi Matsunaga Rieko Okada Yoko Kubo Shiroh Tanoue Yoshifumi Hidaka Takeshi Nishiyama Hiroko Nakagawa-Senda Teruhide Koyama Isao Watanabe Kiyonori Kuriki Naoyuki Takashima Keiko Kondo Masahiro Nakatochi Yukihide Momozawa Takashi Tamura Keitaro Matsuo Coffee intake, genetic variants, and chronic kidney disease: a cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. PURPOSE: The present study aimed to clarify associations between coffee intake and kidney function with consideration of the effect modifications from coffee intake-related genetic polymorphisms. METHODS: This cross-sectional study included 7,468 Japanese participants 35-69 years old (3,953 women: 52.9%) from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Coffee intake was estimated with a self-administered questionnaire. Three coffee intake-related single nucleotide polymorphisms (in AHR [rs4410790], HECTD4 [rs2074356], and CYP1A2 [rs762551]) were selected with reference to previous studies. Estimated glomerular filtration rate (eGFR [ml/min/1.73 m2]) and CKD (defined as eGFR < 60 ml/min/1.73 m2) were determined. RESULTS: In participants with a slow metabolizing genotype of rs4410790, eGFR with higher coffee intake was 1.64 ml/min/1.73 m2 (95% CI 0.29-2.98) lower than with low coffee intake. For a frequent coffee consumer genotype of rs2074356, eGFR in participants with moderate coffee intake was higher than with low coffee intake. For heterozygous-type rs762551, coffee intake was associated with a lower prevalence of CKD (OR: 0.53, 95% CI 0.33-0.83). Moreover, with the frequent coffee consumer genotype of rs2074356, higher coffee intake was associated with a lower prevalence of CKD (OR: 0.27, 95% CI 0.08-0.78). CONCLUSION: Associations of coffee intake with kidney function and CKD may differ across coffee intake-related polymorphisms in Japanese adults. These findings suggest that attention should be paid to heterogeneous associations between coffee intake and kidney function according to genetic polymorphisms. Further longitudinal studies are expected to address causal questions of these associations. European journal of nutrition 64 7 301 301 20251015 10.1007/s00394-025-03819-2 41094118 m_ishizu/published_papers/51751940 Masashi Ishizu Takeshi Watanabe Yuka Torii Kahori Kita Akari Matsuura Taichi Unohara Sakurako Katsuura-Kamano Hirokazu Uemura Association between coffee and adiponectin according to the obesity status: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan. BACKGROUND AND AIMS: Coffee may contribute to the prevention of metabolic abnormalities in both obese and normal weight Japanese adults. Although evidence suggests a relationship between coffee and serum adiponectin, stratified analyses according to the obesity status have not yet been reported. This cross-sectional study examined the relationship between coffee intake and serum high molecular weight (HMW)-adiponectin, which is the most active form of adiponectin, according to the obesity status. METHODS AND RESULTS: The baseline data of 606 participants (aged 35-69 years) living in Tokushima prefecture in the Japan Multi-Institutional Collaborative Cohort Study were analyzed. Coffee intake was assessed using a questionnaire. Participants were stratified by the presence or absence of obesity (normal weight: BMI<25 kg/m2; obesity: BMI≥25 kg/m2). Multiple linear regression analyses adjusted for potential confounders were performed to examine the association between coffee intake and HMW-adiponectin or other diabetic factors. Coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 1.02, 95 % CI 0.30, 1.74), but not in obese subjects. Moreover, filtered/instant coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 0.93, 95 % CI 0.21, 1.65), but not in obese subjects. CONCLUSION: The present study suggests that coffee intake, particularly filtered/instant coffee, is associated with serum HMW-adiponectin in normal weight Japanese adults. Nutrition, metabolism, and cardiovascular diseases : NMCD 35 9 104103 104103 20250900 10.1016/j.numecd.2025.104103 40425402 m_ishizu/published_papers/51751939 Mayuko Yamamoto Yuichi Takashi Masashi Ishizu Kyoko Toyokawa Dai Nagata Kensuke Makihata Haruki Koganemaru Tomoki Sakamoto Kayoko Teshima Yuka Urata Yoshimi Muta Hisashi Yokomizo Dan Sekiguchi Yasutaka Maeda Masae Minami Asuka Kato Daiji Kawanami Association between self-stigma and diabetic complications in Japanese people with type 2 diabetes: a cross-sectional study. OBJECTIVES: To investigate the association between self-stigma evaluated using the Japanese version of the Self-Stigma Scale (SSS-J) and diabetic complications, such as diabetic retinopathy (DR) and diabetic kidney disease (DKD). DESIGN: Cross-sectional study. SETTING: One university hospital and one clinic in Fukuoka, Japan. PARTICIPANTS: People (age ≥20 years) with type 2 diabetes receiving outpatient care, who were treated by diabetologists, and completed the SSS-J questionnaire (n=259). PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the level of self-stigma assessed using the SSS-J. The presence of DR and DKD was evaluated as secondary outcomes. RESULTS: A positive correlation was found between self-stigma and glycated haemoglobin (HbA1c) levels (r=0.132, p=0.034). The mean SSS-J score was significantly higher in people with type 2 diabetes who had DR than in those without DR (p=0.006). There was no significant difference in the mean SSS-J scores of the patients with albuminuria (p=0.318) or a decreased kidney function (p=0.887). Additionally, the relative risk for the presence of DR, as assessed by quartiles of SSS-J scores and a logistic regression analysis, was significantly increased in the Q4 group with the highest SSS-J score after adjustment for sex, age and HbA1c (OR=3.91, 95% CI 1.49 to 10.3, p=0.006). The relative risk for the presence of albuminuria as a DKD significantly increased in the Q4 group immediately after adjustment for sex and age (OR=2.45, 95% CI 1.04 to 5.81, p=0.042). However, this association was attenuated and became non-significant after additional adjustment for HbA1c levels. In contrast, no significant association was observed between the SSS-J score quartiles and decreased kidney function. CONCLUSIONS: The presence of DR was more strongly associated with self-stigma than DKD. Although the causality between self-stigma and the presence of DR could not be elucidated due to the cross-sectional nature of the study, the present study suggests that addressing self-stigma may aid in glycaemic management and the prevention of DR, emphasising the need for healthcare providers to recognise self-stigma as a barrier to optimal diabetes care. BMJ open 15 6 e095698 null 20250617 10.1136/bmjopen-2024-095698 40527574 m_ishizu/published_papers/51751938 Takuma Furukawa Megumi Hara Yuichiro Nishida Keitaro Tanaka Chisato Shimanoe Chiharu Iwasaka Jun Otonari Hiroaki Ikezaki Mako Nagayoshi Takashi Tamura Yudai Tamada Rieko Okada Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takahiro Otani Isao Watanabe Satomi Tomida Kiyonori Kuriki Naoyuki Takashima Aya Kadota Masashi Ishizu Takeshi Watanabe Masahiro Nakatochi Yukihide Momozawa Kenji Wakai Keitaro Matsuo Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups. Polygenic risk scores (PRS) are useful for assessing disease risk; however, knowledge about their effectiveness among Asian and other populations is limited. This study aimed to compare the classification accuracy of PRSs for type 2 diabetes (T2D-PRS) developed from different ancestry groups using genotype data from 14,083 Japanese participants. Participants' scores were calculated using T2D-PRS models, and logistic regression analysis and receiver operating characteristic curves were assessed. The odds ratio of diabetes per 1 standard deviation increase in PRS was 2.18 and 1.55 for the Japanese and European T2D-PRSs, respectively. The area under the curve (AUC) for the Japanese T2D-PRS was 0.781, whereas that for the European T2D-PRS was 0.738 (P < 0.001). Additionally, age-stratified analysis showed higher AUCs in younger than older age groups. The PRS developed from matched ancestry populations has high classification accuracy for diabetes and is particularly useful for the early detection of high-risk individuals with diabetes. npj metabolic health and disease 3 1 17 17 20250503 10.1038/s44324-025-00059-0 40603767 m_ishizu/published_papers/51751941 Sayaka Yamamoto Yuriko N Koyanagi Yuji Iwashita Tomohiro Shinozaki Yutaka Fujiwara Noriaki Sakakura Megumi Hara Yuichiro Nishida Jun Otonari Hiroaki Ikezaki Shiroh Tanoue Chihaya Koriyama Yumiko Kasugai Isao Oze Teruhide Koyama Satomi Tomida Nobuaki Michihata Yohko Nakamura Sadao Suzuki Hiroko Nakagawa-Senda Mako Nagayoshi Yoko Kubo Yasufumi Kato Kenji Wakai Takeshi Watanabe Masashi Ishizu Naoyuki Takashima Aya Kadota Yukihide Momozawa Masahiro Nakatochi Takashi Tamura Akio Niimi Hidemi Ito Keitaro Matsuo Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis. Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate whether these loci are associated with lung cancer risk directly or indirectly through changing smoking behavior. Here, we conducted a case-control study (1427 cases and 5595 controls) and a prospective cohort study (128 incident cases in 10 520 subjects). Using mediation analysis, we decomposed the total effect of the lead single nucleotide polymorphism (SNP) at each locus on lung cancer risk into direct and indirect effects. The results of the two studies were pooled using a random-effects model to estimate summary relative risks (RRs) and their 95% confidence intervals (CIs). Two studies showed that: (i) rs78277894 (EPHX2-CLU, G > A) had a protective direct effect (RR: 0.84; 95% CI: 0.77-0.93) on lung cancer risk; and (ii) rs56129017 (CYP2A6, C > T) had carcinogenic direct and indirect effects on lung cancer risk (RR: 1.26; 95% CI: 1.15-1.39 and RR: 1.01; 95% CI: 1.00-1.01, respectively). This mediation analysis revealed that two smoking behavior-related SNPs, EPHX2-CLU rs78277894 and CYP2A6 rs56129017, were associated with lung cancer risk through pathways independent of changing smoking behavior. Our findings may contribute to our understanding of lung carcinogenesis pathways that cannot be addressed by changes in smoking behavior. Carcinogenesis 46 2 null null 20250403 10.1093/carcin/bgaf011 40059777 m_ishizu/published_papers/51751936 Kenichi Shibuya Rie Ibusuki Daisaku Nishimoto Shiroh Tanoue Chihaya Koriyama Shuhei Niiyama Yasuyuki Kakihana Toshiro Takezaki Megumi Hara Yuichiro Nishida Sadao Suzuki Takeshi Nishiyama Mako Nagayoshi Takashi Tamura Yudai Tamada Rieko Okada Teruhide Koyama Satomi Tomida Kiyonori Kuriki Jun Otonari Hiroaki Ikezaki Asahi Hishida Masashi Ishizu Sakurako Katsuura-Kamano Kenji Wakai Keitaro Matsuo Serum albumin and gamma gap levels, and combined effect for risk of mortality in a Japanese population from the J-MICC study. Although the clinical importance of serum albumin and gamma gap levels is well established, it is unclear how these levels are associated with health risks in the general population. This cohort study aimed to clarify the association between serum albumin and gamma gap levels, and their combined effect, and mortality risk in a Japanese population. The participants totaled 35,746 (17,160 men and 18,586 women) aged 35-69 years from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The mean follow-up period was 11.8 years, with 1,529 deaths and 1,907 censoring. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals after adjusting for related factors. Increased HRs of low albumin and high gamma gap levels were respectively observed for deaths from all-causes, cancer, cardiovascular diseases, respiratory system diseases without pneumonia, and other-causes; and the HR was the highest on respiratory system diseases without pneumonia (HR = 7.31, 4.15-12.9). Low albumin and low gamma gap levels were strongly associated for pneumonia death (HR = 12.4, 3.98-38.5). The interaction between albumin and gamma gap levels was significant for deaths from all-causes, pneumonia and other-causes. The dose relationship for each association was dose-dependent in albumin and threshold-type in gamma gap, except for other-causes. This study suggests that albumin and gamma gap levels are independent indicators of an increased risk of mortality in a Japanese population. Combined effect was apparent for mortality from all-causes, pneumonia, and other-causes. PloS one 20 11 e0336926 null 20250000 10.1371/journal.pone.0336926 41248155 m_ishizu/published_papers/49547244 Taichi Unohara Takeshi Watanabe Kokichi Arisawa Akari Matsuura Kahori Kita Yuka Torii Masashi Ishizu Sakurako Katsuura-Kamano Tien Nguyen Jun Otonari Hiroaki Ikezaki Keitaro Tanaka Chisato Shimanoe Mako Nagayoshi Yoko Kubo Takashi Matsunaga Rieko Okada Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takeshi Nishiyama Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Keiko Kondo Takashi Tamura Keitaro Matsuo Dietary acid load and mortality: Results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Abstract <p>Purpose: The impact of diet on the body acid-base balance may be related to the risk of various chronic diseases. This prospective cohort study examined the relationships between the dietary acid load and all-cause and cause-specific mortalities in a large Japanese population. Methods: The data of 74,360 subjects (aged 35-69 years in the baseline survey) in the Japan Multi-Institutional Collaborative Cohort Study were analyzed. The dietary acid load was estimated using the net endogenous acid production (NEAP) score. Cox proportional hazards regression analyses were performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortalities according to the quartiles of the energy-adjusted NEAP score after adjustments for potential confounders. Results: During a mean follow-up of 11.6 years, 3,761 deaths were identified. A higher NEAP score was associated with higher all-cause (HR 1.16, 95% CI 1.04-1.28) and cerebrovascular disease mortality (HR 1.69, 95% CI 1.08-2.65). Sex-stratified analyses showed that the NEAP score was associated with all-cause and cause-specific mortalities, including cerebrovascular disease mortality in male subjects, but not in female subjects. Conclusion: This study suggest that the dietary acid load is associated with all-cause and cause-specific mortalities, including cerebrovascular disease mortality, in Japanese male adults.</p> Springer Science and Business Media LLC Scientific reports 15 1 41297 41297 20241211 10.21203/rs.3.rs-5297181/v2 41271855 m_ishizu/published_papers/49067096 Miyagawa N Takashima N Harada A Kadota A Kondo K Miura K Imaeda N Goto C Otonari J Ikezaki H Tanaka K Shimanoe C Nagayoshi M Tamura T Kubo Y Kato Y Koyanagi YN Ito H Michihata N Nakamura Y Tanoue S Ibusuki R Suzuki S Nishiyama T Ozaki E Watanabe I Kuriki K Watanabe T Ishizu M Hishida A Kita Y Wakai K Matsuo K J-MICC Study Group Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study. <h4>Aim</h4>We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan.<h4>Methods</h4>We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex.<h4>Results</h4>During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio=0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes.<h4>Conclusion</h4>A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period. Journal of atherosclerosis and thrombosis 32 5 596 607 20241113 10.5551/jat.65049 39537182 m_ishizu/published_papers/49067097 Takeshi Watanabe Tien Van Nguyen Sakurako Katsuura-Kamano Kokichi Arisawa Masashi Ishizu Taichi Unohara Keitaro Tanaka Chisato Shimanoe Mako Nagayoshi Takashi Tamura Yoko Kubo Yasufumi Kato Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Hiroko Nakagawa-Senda Teruhide Koyama Satomi Tomida Kiyonori Kuriki Naoyuki Takashima Akiko HARADA Kenji Wakai Keitaro Matsuo J-MICC Study Group The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study. <h4>Significance</h4>The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes. Cancer research communications 4 11 2986 2997 20241101 10.1158/2767-9764.crc-24-0249 39470380 m_ishizu/published_papers/46313096 Tomoharu Kawano Motohiro Aiba Masashi Ishizu Hiroyasu Mori Munehide Matsuhisa Seiichi Hashida Tracey Colpitts Toshihiro Watanabe Molecular composition of adiponectin in urine is a useful biomarker for detecting early stage of diabetic kidney disease We previously developed two immune complex transfer enzyme immunoassays (ICT-EIA) to measure total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) in urine and have verified their usefulness as biomarkers for diabetic kidney disease. In this study, we developed T-AN and H-AN assays using the sandwich EIA (Sand-EIA). The reactivities of Sand-EIAs were compared with ICT-EIAs by measuring size exclusion chromatography (SEC) fractions of urine and adiponectin standard. As a result, ICT-EIAs showed higher macromolecular specificity. We then analyzed the molecular profile of adiponectin in the urine of 5 patients with different eGFR stages by measuring SEC fractions of urine. The results showed that smaller adiponectin correlated relatively well with eGFR stage. Finally, because SEC is time-consuming, we investigated that the ratio of T-ANs by Sand-EIA and ICT-EIA could be a good indicator of the monomer adiponectin. The ratio was evaluated using 77 urine samples from patients with diabetes and showed a significant decrease at an earlier stage compared with other biomarkers. In conclusion, we demonstrated a new index to estimate monomer adiponectin in urine by using Sand-EIA and ICT-EIA, and urinary monomer adiponectin can be a good early indicator of deterioration of renal function in diabetic patients. J. Med. Invest. 70 : 464-470, August, 2023. University of Tokushima Faculty of Medicine The Journal of Medical Investigation 1349-6867 70 3.4 464 470 20230000 10.2152/jmi.70.464 37940533 m_ishizu/published_papers/49067095 Takeshi Watanabe Arisawa K Nguyen TV Ishizu M Katsuura-Kamano S Hishida A Tamura T Kato Y Okada R Ibusuki R Koriyama C Suzuki S Otani T Koyama T Tomida S Kuriki K Takashima N Miyagawa N Wakai K Matsuo K Japan Multi-Institutional Collaborative Cohort Study Group Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study. <h4>Background and aims</h4>To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population.<h4>Methods and results</h4>We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m²; obesity: BMI ≥25 kg/m²) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not.<h4>Conclusion</h4>The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults. Nutrition, metabolism, and cardiovascular diseases : NMCD 33 3 620 630 20221229 10.1016/j.numecd.2022.12.019 36710119 m_ishizu/published_papers/49067098 Tien Van Nguyen Kokichi Arisawa Katsuura-Kamano S Masashi Ishizu Nagayoshi M Okada R Hishida A Tamura T Megumi Hara Tanaka K Nishimoto D Shibuya K Koyama T Watanabe I Suzuki S Nishiyama T Kuriki K Nakamura Y Yoshino Saito Ikezaki H Otonari J N Koyanagi Y Matsuo K Mikami H Kusakabe M Kenji Takeuchi Wakai K Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. <h4>Purpose</h4>The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.<h4>Methods</h4>We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.<h4>Results</h4>During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).<h4>Conclusion</h4>MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population. PloS one 17 7 e0269550 null 20220708 10.1371/journal.pone.0269550 35802721 m_ishizu/published_papers/38623309 Asami Okada Misuzu Yamada-Yamashita Yukari Tominaga Kyoka Jo Hiroyasu Mori Reiko Suzuki Masashi Ishizu Motoyuki Tamaki Yuko Akehi Yuichi Takashi Daisuke Koga Eisuke Shimokita Fuminori Tanihara Kiyoe Kurahashi Sumiko Yoshida Yukari Mitsui Shiho Masuda Itsuro Endo Ken-Ichi Aihara Shoji Kagami Masahiro Abe Kevin Ferreri Yoshio Fujitani Munehide Matsuhisa Akio Kuroda Novel method utilizing bisulfite conversion with dual amplification-refractory mutation system polymerase chain reaction to detect circulating pancreatic β-cell cfDNA. AIMS/INTRODUCTION: Several research groups have reported methods for quantifying pancreatic beta cell (β-cell) injury by measuring β-cell-specific CpG unmethylation of the insulin gene in circulation using digital droplet PCR or next-generation sequencing. However, these methods have certain disadvantages, such as the need to consider the background signal owing to the small number of target CpG sites and the need for unique equipment. MATERIALS AND METHODS: We established a novel method for detecting four CpG unmethylations of the insulin gene using two-step amplification refractory mutation system PCR. We applied it to type 1 diabetes (T1D) patients with a wide range of disease durations and to healthy adults. RESULTS: The assay showed high linearity and could detect a single copy of unmethylated insulin DNA in experiments using methylated and unmethylated plasmid DNA. The unmethylated insulin DNA level in the type 1 diabetes group, whose β-cell mass was considerably reduced, was similar to that of healthy adults. An inverse correlation was observed between copy number and disease duration in patients with unmethylated insulin DNA-positive type 1 diabetes. CONCLUSIONS: We developed a novel method for detecting unmethylated insulin DNA in circulation that can be performed using a conventional real-time PCR system. This method would be useful for analyzing dynamic profiles of β-cells in human disease such as type 1 diabetes. Journal of diabetes investigation 13 7 1140 1148 20220409 10.1111/jdi.13806 35396829 m_ishizu/published_papers/32172089 Masashi Ishizu Hiroyasu Mori Mami Ohishi Akio Kuroda Yuko Akehi Sumiko Yoshida Ken-Ichi Aihara Motohiro Aiba Tomoharu Kawano Seiichi Hashida Munehide Matsuhisa Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus. AIMS: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. METHODS: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). RESULTS: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 mL/min/1.73m2, >-10 and ≤0 mL/min/1.73m2, and >0 mL/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. CONCLUSION: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes. Journal of diabetes and its complications 35 4 107848 107848 20210400 10.1016/j.jdiacomp.2021.107848 33558151 m_ishizu/published_papers/32172088 Yukari Mitsui Akio Kuroda Masashi Ishizu Hiroyasu Mori Kiyoe Kurahashi Takeshi Kondo Sumiko Yoshida Yuko Akehi Ken-Ichi Aihara Itsuro Endo Masahiro Abe Munehide Matsuhisa Basal insulin requirement in patients with type 1 diabetes depends on the age and body mass index. AIMS/INTRODUCTION: To investigate the basal insulin requirement in patients with type 1 diabetes (T1D) who are on multiple daily injections (MDI) and assess the patient characteristics that affect the percent of total daily basal insulin dose to total daily insulin dose (%TBD/TDD). MATERIALS AND METHODS: The subjects of this study were 67 inpatients with T1D who were served diabetic meals of 25-30 kcal/kg standard body weight during several weeks of hospitalization. The basal insulin requirement was adjusted to keep the blood glucose level from bedtime to before breakfast within a 30-mg/dL difference. The bolus insulin dose before meal was adjusted to keep the blood glucose level below 140 and 200 mg/dL before and 2 h after each meal, respectively. The total daily insulin dose (TDD), percent of total daily basal insulin dose (TBD) to TDD (%TBD/TDD), and clinical characteristics were collected. RESULTS: The median (Q1, Q3) of TDD was 33.0 (26.0, 49.0) units, and the %TBD/TDD was 24.1% ± 9.8%. The %TBD/TDD was positively correlated with the body mass index (BMI) and negatively correlated with the age at the onset and at the examination according to a univariate analysis. However, the %TBD/TDD was dependent on the BMI (β = 0.340, p = 0.004) and age at the examination (β = -0.288, p = 0.012) according to the multiple regression analysis. CONCLUSIONS: The average %TBD/TDD in patients with T1D on MDI was approximately 24% under inpatient conditions. The basal insulin requirement was dependent on the BMI and age at the examination. Journal of diabetes investigation 13 2 292 298 20210319 10.1111/jdi.13547 33740836 m_ishizu/published_papers/32172090 Toshihiro Watanabe Yuki Fujimoto Aya Morimoto Mai Nishiyama Akinori Kawai Seiki Okada Motohiro Aiba Tomoharu Kawano Mina Kawahigashi Masashi Ishizu Hiroyasu Mori Munehide Matsuhisa Akiko Hata Makoto Funaki Seiichi Hashida Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease. Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance over conventional biomarkers were investigated. The T-AN and H-AN assays had high reproducibility, good linearity, and sufficient sensitivity to detect trace amounts of adiponectin in the urine. Urine samples after gel filtration were analyzed for the presence of different molecular isoforms. Low molecular weight (LMW) forms and monomers were the major components (93%) of adiponectin in the urine from a diabetic patient with normoalbuminuria. Urine from a microalbuminuria patient contained both high molecular weight (HMW) (11%) and middle molecular weight (MMW) (28%) adiponectin, although the LMW level was still high (52%). The amount of HMW (32%) and MMW (42%) were more abundant than that of LMW (24%) in a diabetic patient with macroalbuminuria. T-AN (r = - 0.43) and H-AN (r = - 0.38) levels showed higher correlation with estimated GFR (eGFR) than UAER (r = - 0.23). Urinary levels of both T-AN and H-AN negatively correlated with renal function in diabetic patients and they may serve as new biomarkers for diabetic kidney disease. Scientific reports 10 1 15869 15869 20200928 10.1038/s41598-020-72494-6 32985540 m_ishizu/published_papers/32172091 Yuichi Takashi Shu Wakino Hitoshi Minakuchi Masashi Ishizu Akio Kuroda Hisato Shima Manabu Tashiro Keiko Miya Kazuyoshi Okada Jun Minakuchi Shu Kawashima Munehide Matsuhisa Toshio Matsumoto Seiji Fukumoto Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients. Fibroblast growth factor (FGF) 23 is a bone-derived hormone regulating serum inorganic phosphate (Pi) concentration. FGF23 is also involved in the development of chronic kidney disease (CKD)-mineral and bone disorder. Serum FGF23 concentration begins to increase early in the progression of CKD and can be remarkably high in hemodialysis patients with end-stage renal disease. It has been reported that high FGF23 concentration is a risk factor for cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. FGF23 was also shown to induce cardiac hypertrophy directly acting on cardiomyocytes. However, it is still controversial whether high FGF23 is causing cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. In the current study, we investigated whether FGF23 concentration is associated with cardiac dysfunction, atherosclerosis, infection or systemic inflammation in Japanese hemodialysis patients. We recruited 119 hemodialysis patients and examined the association between serum FGF23 concentration and several parameters concerning mineral metabolism, cardiac dysfunction, atherosclerosis, infection, and systemic inflammation. Serum FGF23 concentration was independently associated with serum calcium and Pi concentration (β = 0.276, p < 0.001; β = 0.689, p < 0.001). However, serum FGF23 concentration was not associated with parameters of cardiac dysfunction, atherosclerosis, infection, and systemic inflammation, either. Our results do not support the hypothesis that high FGF23 in dialysis patients is the cause of cardiac dysfunction, atherosclerosis, infection or systemic inflammation. Journal of bone and mineral metabolism 38 1 70 77 20200100 10.1007/s00774-019-01027-7 31420749 m_ishizu/published_papers/32172093 Hiroyasu Mori Akio Kuroda Masashi Ishizu Mami Ohishi Yuichi Takashi Yinhua Otsuka Satoshi Taniguchi Motoyuki Tamaki Kiyoe Kurahashi Sumiko Yoshida Itsuro Endo Ken-Ichi Aihara Makoto Funaki Yuko Akehi Munehide Matsuhisa Association of accumulated advanced glycation end-products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes. AIMS/INTRODUCTION: Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as with aging in patients with diabetes. The loss of muscle mass and strength, so-called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes. MATERIALS AND METHODS: We recruited 166 patients with type 2 diabetes aged ≥30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m2 ; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed. RESULTS: Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia. CONCLUSIONS: Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes. Journal of diabetes investigation 10 5 1332 1340 20190900 10.1111/jdi.13014 30677242 m_ishizu/published_papers/32172092 Yuichi Takashi Masashi Ishizu Hiroyasu Mori Kazuyuki Miyashita Fumie Sakamoto Naoto Katakami Taka-Aki Matsuoka Tetsuyuki Yasuda Seiichi Hashida Munehide Matsuhisa Akio Kuroda Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes. The objective of the present study was to investigate the correlations between serum undercarboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with %body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes. PloS one 14 5 e0216416 null 20190000 10.1371/journal.pone.0216416 31050684 m_ishizu/published_papers/32172095 Tirani Bahari Hirokazu Uemura Sakurako Katsuura-Kamano Miwa Yamaguchi Mariko Nakamoto Keisuke Miki Masashi Ishizu Kokichi Arisawa Nutrient-Derived Dietary Patterns and Their Association With Metabolic Syndrome in a Japanese Population. BACKGROUND: Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. METHODS: The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture. Dietary patterns were derived with RRR using 46 food items as predictors and six established nutrients (potassium, calcium, vitamin D, vitamin C, insoluble dietary fiber, and carotene) as response variables. Associations between extracted dietary patterns and MetS were then examined with logistic regression models. RESULTS: Among the six dietary patterns, dietary pattern 1 (DP1) explained the largest proportion (60.1%) of variance in the six nutrients. Therefore, only DP1 was selected for further analysis. DP1 was characterized by high intake frequency of vegetables, fruits, fish and small fish, natto (fermented soybeans), and deep-fried tofu. After adjustment for potential confounders, significant inverse associations were found between DP1 score and MetS (odds ratio [OR] for each quartile: 1.00, 0.58, 0.60, 0.52; Ptrend = 0.02); DP1 and high blood pressure (Ptrend = 0.0002); and DP1 and high blood glucose (Ptrend = 0.02). CONCLUSION: A dietary pattern characterized by high intake of vegetables, fruits, fish and small fish, natto, and deep-fried tofu was associated with reduced prevalence of MetS in a Japanese population. Journal of epidemiology 28 4 194 201 20180405 10.2188/jea.JE20170010 29151477 m_ishizu/published_papers/32172094 Sakurako Katsuura-Kamano Hirokazu Uemura Miwa Yamaguchi Mariko Nakamoto Tirani Bahari Keisuke Miki Masashi Ishizu Fusakazu Sawachika Kokichi Arisawa Dietary calcium intake is associated with serum high-sensitivity C-reactive protein level in the general Japanese population. The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associations between dietary calcium intake and serum high-sensitivity C-reactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a cross-sectional study of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated food-frequency questionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels (p for trend <0.001) after adjustment for age, sex, research group, leisure-time physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and menopausal status. The association was slightly attenuated after additional adjustment for body mass index; however, remained significant (p for trend = 0.008). There were no significant interactions between dietary calcium intakes and sex, body mass index, or vitamin D intake for high-sensitivity C-reactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels in the general population. Journal of clinical biochemistry and nutrition 62 1 89 93 20180100 10.3164/jcbn.17-48 29371759 m_ishizu/published_papers/32172097 Hirokazu Uemura A Ammar Ghaibeh Sakurako Katsuura-Kamano Miwa Yamaguchi Tirani Bahari Masashi Ishizu Hiroki Moriguchi Kokichi Arisawa Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree. To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35-69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes (P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes (P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes. Scientific reports 7 45502 45502 20170331 10.1038/srep45502 28361994 m_ishizu/published_papers/32172096 Hirokazu Uemura Sakurako Katsuura-Kamano Miwa Yamaguchi Tirani Bahari Masashi Ishizu Miho Fujioka Kokichi Arisawa Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort. BACKGROUND: Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort. METHODS: We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ≥25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP (≤median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated. RESULTS: Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA-β, after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP (≤median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP (≤median, >median) on HOMA-IR was significant (P for interaction <0.001). CONCLUSIONS: Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance. PloS one 12 6 e0178672 null 20170000 10.1371/journal.pone.0178672 28575103 m_ishizu/misc/51751963 上村浩一 上村浩一 釜野桜子 釜野桜子 石津将 石津将 渡邊毅 渡邊毅 日本の中高年女性における出産歴および月経状況と血中尿酸値との関連 日本衛生学雑誌(Web) 1882-6482 80 Supplement null null 20250000 m_ishizu/misc/51751962 卯之原大治 卯之原大治 渡邊毅 松浦朱里 松浦朱里 北佳穂里 北佳穂里 鳥居優花 鳥居優花 村上有見子 村上有見子 石津将 食事酸負荷と死亡率:J-MICC Study 日本疫学会学術総会講演集(Web) 35th null null 20250000 m_ishizu/misc/51751961 渡邊毅 藤井亮輔 原倫世 村上有見子 村上有見子 松浦朱里 松浦朱里 鳥居優花 鳥居優花 北佳穂里 北佳穂里 卯之原太治 卯之原太治 石津将 KCNQ1遺伝的多型を考慮したコーヒー摂取および栄養素パターンと高血糖との関連 日本疫学会学術総会講演集(Web) 35th null null 20250000 m_ishizu/misc/51751960 須磨紫乃 釜野桜子 釜野桜子 片岡宏介 渡邊毅 石津将 大豆食品摂取量が全死因死亡・死因別死亡に与える影響:J-MICC Study 日本疫学会学術総会講演集(Web) 35th null null 20250000 m_ishizu/misc/51751959 上村浩一 釜野桜子 石津将 渡邊毅 月経状況や生殖歴と慢性炎症,インスリン抵抗性や血中アディポネクチン値との関連 日本疫学会学術総会講演集(Web) 35th null null 20250000 m_ishizu/misc/51751958 石津将 鈴木麗子 黒田暁生 松久宗英 徳島県市町村国保特定健診・後期高齢者医療健診における心電図異常に関わる因子の後向き検討 日本疫学会学術総会講演集(Web) 35th null null 20250000 m_ishizu/misc/51751969 釜野桜子 石津将 渡邊毅 出生体重と日本人中高年の不安特性との関連:J-MICC Study徳島地区調査 日本疫学会学術総会講演集(Web) 34th null null 20240000 m_ishizu/misc/51751968 石津将 鈴木麗子 黒田暁生 松久宗英 心電図異常における糖尿病の意義の検討-令和3年度徳島県市町村国保特定健診・後期高齢者医療健診データの解析結果- 日本糖尿病インフォマティクス学会年次学術集会プログラム・抄録集 24th null null 20240000 m_ishizu/misc/51751967 山本真悠子 高士祐一 石津将 豊川恭子 永田大 牟田芳実 横溝久 関口男 関口男 前田泰孝 前田泰孝 南昌江 南昌江 加藤明日香 川浪大治 2型糖尿病におけるセルフスティグマと糖尿病合併症の関連 糖尿病合併症 38 Supplement-1 null null 20240000 m_ishizu/misc/51751966 上村浩一 上村浩一 釜野桜子 石津将 渡邊毅 日本人女性における生殖関連要因と動脈スティフネスとの関連:J-MICC Study徳島地区調査 日本女性医学学会雑誌 2185-8861 32 1 null null 20240000 m_ishizu/misc/51751965 山本真悠子 高士祐一 加藤明日香 石津将 豊川恭子 牟田芳実 横溝久 関口男 前田泰孝 南昌江 関口男 前田泰孝 南昌江 川浪大治 2型糖尿病におけるセルフスティグマと糖尿病合併症に関する単施設検討 糖尿病(Web) 1881-588X 67 Suppl null null 20240000 m_ishizu/misc/51751964 上村浩一 釜野桜子 石津将 渡邊毅 出産回数や月経状況と動脈スティフネスとの関連:J-MICC Study徳島地区調査 日本公衆衛生学会総会抄録集(CD-ROM) 83rd null null 20240000 m_ishizu/misc/51751972 釜野桜子 有澤孝吉 石津将 渡邊毅 NGUYEN Van Tien 大豆製品およびイソフラボン摂取量と糖尿病罹患との関連:J-MICC Study 日本疫学会学術総会講演集(Web) 33rd null null 20230000 m_ishizu/misc/51751971 渡邊毅 有澤孝吉 グエン バンティエン 石津将 釜野桜子 コーヒー摂取と代謝表現型:J-MICC Studyのベースラインデータを用いた横断研究 日本疫学会学術総会講演集(Web) 33rd null null 20230000 m_ishizu/misc/51751970 黒田暁生 岡田朝美 森博康 冨永ゆかり 石津将 松久宗秀 循環血中遊離DNAを標的とした血管内皮細胞傷害の検出 糖尿病合併症 37 Supplement-1 null null 20230000 m_ishizu/misc/51751975 三井由加里 黒田暁生 石津将 倉橋清衛 吉田守美子 明比祐子 遠藤逸朗 遠藤逸朗 粟飯原賢一 安倍正博 松久宗英 頻回インスリン注射療法下の1型糖尿病患者における基礎インスリン比率の検討 日本先進糖尿病治療研究会雑誌(Web) 2436-0058 16 2 null null 20220000 m_ishizu/misc/51751974 黒田暁生 黒田暁生 鶴尾美穂 石津将 松久宗英 Time-In-RangeとHbA1cとの関連~HbA1cと組み合わせる血糖管理方法~ 日本先進糖尿病治療研究会雑誌(Web) 2436-0058 16 2 null null 20220000 m_ishizu/misc/51751973 石津将 森博康 明比祐子 黒田暁生 田蒔基行 吉田守美子 粟飯原賢一 藍場元弘 河野友晴 橋田誠一 松久宗英 糖尿病性腎臓病における尿アディポネクチンの意義(第2報) 糖尿病(Web) 1881-588X 65 11 null null 20220000 m_ishizu/misc/32172377 黒田 暁生 石津 将 鶴尾 美穂 森 博康 明比 祐子 岡本 美鈴 鈴木 麗子 寺澤 敏秀 松久 宗英 持続グルコースモニタリングの推定HbA1c値と実測HbA1c値との解離に関する検討 (NPO)日本糖尿病情報学会 日本糖尿病情報学会年次学術集会プログラム・抄録集 1881-588X 20 11 29 29 20200900 m_ishizu/misc/32172376 三井 由加里 黒田 暁生 石津 将 桝田 志保 倉橋 清衛 吉田 守美子 明比 祐子 遠藤 逸朗 粟飯原 賢一 安倍 正博 頻回インスリン注射療法下の1型糖尿病患者における基礎インスリン比率の検討 (一社)日本糖尿病学会 糖尿病 1881-588X 63 9 636 636 20200900 m_ishizu/misc/32172375 鶴尾 美穂 住友 正治 小松 まち子 大島 康志 坂東 智子 森 博康 石津 将 高橋 保子 粟飯原 賢一 松久 宗英 徳島市医師会糖尿病腎症重症化予防パイロット事業後アンケート結果 (一社)日本糖尿病学会 糖尿病 1881-588X 63 9 652 652 20200900 m_ishizu/misc/32172379 森 博康 石津 将 大石 真実 大塚 銀花 鈴木 麗子 吉田 守美子 粟飯原 賢一 明比 祐子 黒田 暁生 松久 宗英 糖尿病腎症の急速進行に関連するリスク因子と栄養食事摂取状況の検証 (一社)日本リハビリテーション栄養学会 リハビリテーション栄養 3 2 309 310 20191000 m_ishizu/misc/32172378 石津 将 森 博康 大石 真実 鈴木 麗子 岡本 美鈴 明比 祐子 黒田 暁生 田蒔 基行 高士 祐一 吉田 守美子 粟飯原 賢一 藍場 元弘 河野 友晴 橋田 誠一 松久 宗英 糖尿病性腎臓病における尿中へのアディポネクチン排泄の臨床的意義 (一社)日本肥満学会 肥満研究 1343-229X 25 Suppl. 250 250 20191000 m_ishizu/misc/32172381 鈴木 麗子 森 博康 石津 将 玉木 悠 谷口 諭 黒田 暁生 松久 宗英 スマートスピーカーを活用した個別化糖尿病自己管理支援システムの開発 糖尿病患者の行動変容を目指して (NPO)日本糖尿病情報学会 日本糖尿病情報学会年次学術集会プログラム・抄録集 19 17 17 20190800 m_ishizu/misc/32172380 石津 将 鶴尾 美穂 豊崎 纒 粟飯原 賢一 坂東 智子 住友 正治 古川 浩 宮本 泰文 小松 まち子 大島 康志 桜井 えつ 若槻 真吾 岡川 和人 林 正 松村 光博 小川 紘一 保岡 正治 細井 恵美子 丸岡 重代 西岡 恵子 高橋 保子 森 博康 松久 宗英 宇都宮 正登 徳島市医師会糖尿病腎症重症化予防パイロット事業の報告 (NPO)日本糖尿病情報学会 日本糖尿病情報学会年次学術集会プログラム・抄録集 19 22 22 20190800 m_ishizu/misc/32172383 石津 将 森 博康 大石 真実 鈴木 麗子 岡本 美鈴 明比 祐子 黒田 暁生 田蒔 基行 高士 祐一 吉田 守美子 粟飯原 賢一 藍場 元弘 河野 友晴 橋田 誠一 松久 宗英 糖尿病性腎臓病における尿中アディポネクチン排泄率の臨床的意義の検討 (一社)日本糖尿病学会 糖尿病 1881-588X 62 Suppl.1 S 169 20190400 m_ishizu/misc/32172382 鶴尾 美穂 豊崎 纒 小松 まち子 住友 正治 大島 康志 粟飯原 賢一 森 博康 石津 将 岡川 和人 小川 紘一 古川 浩 桜井 えつ 林 正 坂東 智子 細井 恵美子 松村 光博 宮本 泰文 保岡 正治 高橋 保子 丸岡 重代 西岡 恵子 宇都宮 正登 松久 宗英 徳島市医師会糖尿病腎症重症化予防パイロット事業の取組み (一社)日本糖尿病学会 糖尿病 1881-588X 62 Suppl.1 S 280 20190400 m_ishizu/misc/32172386 石津 将 森 博康 大石 真実 鈴木 麗子 明比 祐子 黒田 暁生 田蒔 基行 高士 祐一 吉田 守美子 粟飯原 賢一 藍場 元弘 河野 友晴 橋田 誠一 松久 宗英 糖尿病性腎臓病における尿アディポネクチンの意義 (一社)日本糖尿病学会 糖尿病 1881-588X 62 2 123 123 20190200 m_ishizu/misc/32172385 森 博康 荒木 迪子 黒田 暁生 石津 将 高士 祐一 谷口 論 倉橋 清衛 吉田 守美子 遠藤 逸朗 粟飯原 賢一 田蒔 基行 明比 祐子 松久 宗英 1型糖尿病患者の血清IGF-1とサルコペニア合併に関する横断的検証 (一社)日本内分泌学会 日本内分泌学会雑誌 2186-506X 94 3 1074 1074 20181200 m_ishizu/misc/32172384 高士 祐一 石津 将 脇野 修 水口 斉 島 久登 田代 学 宮 恵子 水口 潤 黒田 暁生 松本 俊夫 松久 宗英 福本 誠二 血液透析患者における心不全・動脈硬化・感染のリスク因子としてのFGF23 (一社)日本内分泌学会 日本内分泌学会雑誌 2186-506X 94 3 1081 1081 20181200 m_ishizu/misc/32172387 森 博康 黒田 暁生 石津 将 高士 祐一 谷口 論 田蒔 基行 明比 祐子 松久 宗英 2型糖尿病患者における肥満と筋障害との関連の検証 (一社)日本肥満学会 肥満研究 1343-229X 24 Suppl. 228 228 20180900 m_ishizu/misc/32172393 大石 真実 森 博康 鈴木 麗子 明比 祐子 黒田 暁生 田蒔 基行 谷口 諭 石津 将 阪上 浩 松久 宗英 急速進行性糖尿病腎症に関連するリスク因子の検討 (一社)日本糖尿病学会 糖尿病 1881-588X 61 5 344 344 20180500 m_ishizu/misc/32172392 森 博康 鈴木 麗子 瀧川 稲子 石津 将 大石 真実 谷口 諭 明比 祐子 黒田 暁生 松久 宗英 糖尿病腎症の急速進行に関連するリスク因子の検証 前向き観察研究 (一社)日本糖尿病学会 糖尿病 1881-588X 61 Suppl.1 S 140 20180400 m_ishizu/misc/32172391 田蒔 基行 高士 祐一 乙田 敏城 福本 誠二 黒田 暁生 明比 祐子 森 博康 谷口 諭 鈴木 麗子 山田 美鈴 石津 将 大石 真実 白神 敦久 粟飯原 賢一 船木 真理 松久 宗英 かかりつけ患者に対するSGLT2阻害薬の投与開始タイミングの特徴と，投与開始後の体重・eGFR・ALT・脂質代謝の変化 (一社)日本糖尿病学会 糖尿病 1881-588X 61 Suppl.1 S 159 20180400 m_ishizu/misc/32172390 石津 将 高士 祐一 脇野 修 水口 斉 田代 学 宮 恵子 野間 喜彦 小松 まち子 水口 潤 黒田 暁生 福本 誠二 松久 宗英 血液透析患者における糖尿病をはじめとする動脈硬化リスク因子の検討 (一社)日本糖尿病学会 糖尿病 1881-588X 61 Suppl.1 S 202 20180400 m_ishizu/misc/32172389 高士 祐一 石津 将 森 博康 宮下 和幸 坂本 扶美枝 片上 直人 松岡 孝昭 安田 哲行 橋田 誠一 黒田 暁生 松久 宗英 骨産生ホルモンucOCは1型糖尿病患者の体脂肪率と関係する (一社)日本糖尿病学会 糖尿病 1881-588X 61 Suppl.1 S 251 20180400 m_ishizu/misc/32172388 黒田 暁生 山田 美鈴 冨永 ゆかり 鈴木 麗子 田蒔 基行 明比 祐子 高士 祐一 石津 将 古賀 大輔 井本 逸勢 倉橋 清衛 吉田 守美子 遠藤 逸朗 粟飯原 賢一 安倍 正博 Ferreri Kevin 松久 宗英 膵β細胞特異的PCRによる膵β細胞死の検出 (一社)日本糖尿病学会 糖尿病 1881-588X 61 Suppl.1 S 399 20180400 m_ishizu/misc/32172394 上村 浩一 釜野 桜子 山口 美輪 Bahari Tirani 石津 将 藤岡 美穂 有澤 孝吉 一般集団における慢性炎症とインスリン代謝関連指標との関係の検討 (一社)日本衛生学会 日本衛生学雑誌 1882-6482 72 Suppl. S250 S250 20170300 m_ishizu/misc/32172395 上村 浩一 釜野 桜子 山口 美輪 Bahari Tirani 三木 啓輔 石津 将 有澤 孝吉 肥満および慢性炎症とインスリン抵抗性との関連 J-MICC Study徳島地区調査より (一社)日本衛生学会 日本衛生学雑誌 1882-6482 71 Suppl. S218 S218 20160500 m_ishizu/misc/32172396 三木 啓輔 上村 浩一 釜野 桜子 山口 美輪 Tirani Bahari 澤近 房和 石津 将 有澤 孝吉 カリウム・ビタミンB1・ビタミンB2の摂取とインスリン抵抗性との関連についての検討 J-MICC Study徳島地区のデータより 四国公衆衛生学会 四国公衆衛生学会雑誌 0286-2964 61 1 26 26 20160200