label: url

en: A case of treatmentresistant advanced gastric cancer with FGFR2gene alteration successfully treated with pemigatinib.

en: International Cancer Conference Journal

ja: International Cancer Conference Journal

volume: Vol.in press


en: Therapeutic efficacy of lenvatinib in nonviral unresectable hepatocellular carcinoma.

en: JGH Open

ja: JGH Open


en: MiR-125b-5p is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.

en: The mechanism of resistance to sorafenib in hepatocellular carcinoma (HCC) remains unclear. We analyzed miRNA expression profiles in sorafenib-resistant HCC cell lines (PLC/PRF5-R1/R2) and parental cell lines (PLC/PRF5) to identify the miRNAs responsible for resistance. Drug sensitivity, migration/invasion capabilities, and epithelial-mesenchymal transition (EMT) properties were analyzed by biochemical methods. The clinical relevance of the target genes to survival in HCC patients were assessed using a public database. Four miRNAs were significantly upregulated in PLC/PRF5-R1/-R2 compared with PLC/PRF5. Among them, miR-125b-5p mimic-transfected PLC/PRF5 cells (PLC/PRF5-miR125b) and showed a significantly higher IC50 for sorafenib compared with controls, while the other miRNA mimics did not. PLC/PRF5-miR125b showed lower E-cadherin and higher Snail and vimentin expression-findings similar to those for PLC/PRF5-R2-which suggests the induction of EMT in those cells. PLC/PRF5-miR125b exhibited significantly higher migration and invasion capabilities and induced sorafenib resistance in an in vivo mouse model. Bioinformatic analysis revealed ataxin-1 as a target gene of miR-125b-5p. PLC/PRF5 cells transfected with ataxin-1 siRNA showed a significantly higher IC50, higher migration/invasion capability, higher cancer stem cell population, and an EMT phenotype. Median overall survival in the low-ataxin-1 patient group was significantly shorter than in the high-ataxin-1 group. In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients.

en: Cancers

ja: Cancers


en: A CASE OF MULTIPLE COLONIC ULCERS CAUSED BY RHEUMATOID VASCULITIS

ja: 関節リウマチの経過中に発生したリウマトイド血管炎に起因する多発大腸潰瘍の1例.

en: Gastroenterological Endoscopy

ja: Gastroenterological Endoscopy


en: A Case of IgG4-related Disease that Developed 10Years after Onset of Type2 Diabetes Mellitus

ja: 2型糖尿病発症から10年を経て発症したIgG4関連疾患の1例

en: 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal