徳島大学 / 教育研究者総覧 --- 小田輝王

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 共同研究講座 ⟩ 先端脳機能研究開発 ⟩

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著書・論文

学術論文(審査論文):

1.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia and Parkinson's disease., Scientific Reports, Vol.13, No.1, 2023. (要約) Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms. (キーワード) Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus (徳島大学機関リポジトリ) ● Metadata: 118394 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-37833-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081 ● Search Scopus @ Elsevier (PMID): 37420081 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3 (徳島大学機関リポジトリ: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081)
2.	Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi and Yasushi Takagi : Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials., Frontiers in Aging Neuroscience, Vol.14, 2022. (要約) Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these. (徳島大学機関リポジトリ) ● Metadata: 117340 (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fnagi.2022.807909 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35462692 ● Search Scopus @ Elsevier (PMID): 35462692 ● Search Scopus @ Elsevier (DOI): 10.3389/fnagi.2022.807909 (徳島大学機関リポジトリ: 117340, DOI: 10.3389/fnagi.2022.807909, PubMed: 35462692)

国際会議:

1.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.
2.	NAKANISHI Hiroshi, Ryoma Morigaki, Nobuaki Yamamoto, Joji Fujikawa, Teruo Oda, OMAE Hiroshi, Yuishin Izumi and Yasushi Takagi : The effect of Rikaba, a hybrid physical exercise salon for Parkinson's disease patients, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.
3.	Ryoma Morigaki, Maya Anzai, Joji Fujikawa, Teruo Oda, Hayasawa Hiroaki, Matsuda Taku, Jiro Kasahara and Yasushi Takagi : Changes in phosphodiesterase 10A in mice model of levodopa-induced dyskinesia, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.

国内講演発表:

1.	森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 : 特発性ジストニア患者の頭蓋骨の歪み, 日本定位・機能神経外科学会機関紙, 2022年1月.
2.	森垣龍馬, 藤川丈自, 小田輝王, 中西浩, 山本伸昭, 三宅一央, 松田拓, 髙木康志 : 機械学習を用いた脳線条体免疫染色画像の解析, 日本脳神経外科学会学術総会, 2021年10月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

ふたつの異なるモデルによるジストニア発症機序と治療ターゲットの解明 (研究課題/領域番号: 23K08523 )
研究者番号（70911543）による検索