徳島大学 / 教育研究者総覧 --- 阿部あかね

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著書・論文

学術論文(審査論文):

1.	Makoto Tobiume, Atsushi Mitsuhashi, Atsuro Saijo, Hirokazu Ogino, Tania Afroj, Hirohisa Ogawa, Hisatsugu Goto, Seidai Satou, Akane Abe, Keiko Haji, Ryohiko Ozaki, Hiromitsu Takizawa and Yasuhiko Nishioka : Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer., Oncology Letters, Vol.24, No.5, 417, 2022. (要約) Fibrocytes, which are bone marrow-derived collagen-producing cells, have been reported to be involved in pathogenesis of pulmonary fibrosis. Our previous study reported that tumor-infiltrating fibrocytes play a role in tumor progression and drug resistance in lung cancer. The present study therefore examined chemotactic factors for fibrocytes in tissues of non-small cell lung cancer (NSCLC) and their prognostic significance. Surgically resected tumor tissues were examined for the expression of chemotactic factors, including C-X-C motif chemokine 12 (CXCL12), CCL2, platelet-derived growth factor (PDGF)-AA and PDGF-BB, as well as tumor-infiltrating fibrocytes by immunostaining. The chemotactic ability of fibrocytes in response to each factor was evaluated using a migration assay by counting the migrated cells microscopically, and expression of receptors for chemotactic factors were analyzed by flow cytometry. The expression of CXCL12, but not CCL2, PDGF-AA, or PDGF-BB, was associated with the number of tumor-infiltrating fibrocytes in lung adenocarcinoma (LUAD), but not lung squamous cell carcinoma (LUSQ). In addition, patients with an increased expression of CXCL12 in LUAD but not LUSQ showed a significantly poorer prognosis compared with those with a decreased expression. However, the expression of CCL2, PDGF-AA and PDGF-BB was not correlated with the prognosis of patients with NSCLC. The number of fibrocytes was associated with a poor prognosis in LUAD. Fibrocytes derived from the peripheral blood of healthy subjects as well as patients with lung cancer expressed higher levels of CXCR4 compared with CCR2, PDGF and receptor-α and receptor-β. Overall, these results suggested that targeting tumor-infiltrating fibrocytes via the CXCL12/CXCR4 axis may be a useful strategy for controlling the progression of NSCLC, particularly LUAD. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13537 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36245829 ● Search Scopus @ Elsevier (PMID): 36245829 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13537 (DOI: 10.3892/ol.2022.13537, PubMed: 36245829)
2.	Naoto Okada, Akikazu Murakami, Masami Satou, Shingen Nakamura, Shiroh Fujii, Kimiko Sogabe, Mamiko Takahashi, Asami Okada, Akane Abe, Hideki Fujii, Masahiro Abe, Momoyo Azuma and Keisuke Ishizawa : First reported case of Lachnoanaerobaculum gingivalis bacteremia in an acute myeloid leukemia patient with oral mucositis during high dose chemotherapy., Anaerobe, Vol.76, 2022. (要約) During chemotherapy in patients with oral mucositis, we should consider the possibility of L. gingivalis bacteremia. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.anaerobe.2022.102610 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35811059 ● Search Scopus @ Elsevier (PMID): 35811059 ● Search Scopus @ Elsevier (DOI): 10.1016/j.anaerobe.2022.102610 (DOI: 10.1016/j.anaerobe.2022.102610, PubMed: 35811059)
3.	Masahiro Sako, Hiroshi Nokihara, Kensuke Kondo, Atsushi Mitsuhashi, Ryohiko Ozaki, Yohei Yabuki, Akane Abe, Hiroto Yoneda, Hirokazu Ogino, Kenji Otsuka, Hisanori Uehara and Yasuhiko Nishioka : A case of pulmonary pleomorphic carcinoma with preexisting interstitial pneumonia successfully treated with pembrolizumab., Thoracic Cancer, Vol.13, No.1, 129-132, 2021. (要約) Pulmonary pleomorphic carcinoma is often refractory to chemotherapy and follows an aggressive clinical course. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced lung cancer, and a few cases with pleomorphic carcinoma have been reported to show tumor shrinkage after therapy with ICIs. When treating patients with ICIs, patient selection is essential, and monitoring and management of immune-related adverse events, including pneumonitis, are needed. We herein report a case of pulmonary pleomorphic carcinoma with preexisting interstitial pneumonia treated with pembrolizumab, antiprogrammed cell death 1 antibody. Our report highlights important considerations necessary when treating advanced pleomorphic carcinoma patients complicated with interstitial pneumonia. We also review the literature regarding the use of ICIs in such patients. (キーワード) Aged / Antibodies, Monoclonal, Humanized / Carcinoma, Non-Small-Cell Lung / Humans / Immune Checkpoint Inhibitors / Lung Diseases, Interstitial / Lung Neoplasms / 男性 (male) (徳島大学機関リポジトリ) ● Metadata: 117393 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/1759-7714.14243 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34859591 ● Search Scopus @ Elsevier (PMID): 34859591 ● Search Scopus @ Elsevier (DOI): 10.1111/1759-7714.14243 (徳島大学機関リポジトリ: 117393, DOI: 10.1111/1759-7714.14243, PubMed: 34859591)

国内講演発表:

1.	青井優, 坂東弘基, 土師恵子, 高橋啓輝, 米田浩人, 阿部あかね, 佐藤正大, 東桃代, 埴淵昌毅, 西岡安彦 : 気管支鏡検査で診断したCOVID-19関連肺アスペルギルス症の1例, 第32回日本呼吸器内視鏡学会中国四国支部会, 2023年12月.
2.	中西渓介, 坂東弘基, 土師恵子, 小倉祐一郎, 美馬正人, 内藤伸仁, 阿部あかね, 川真田純, 杉浦宏, 佐藤正大, 東桃代, 埴淵昌毅, 西良浩一, 西岡安彦 : 結核性脊椎炎の治療中にparadoxical responseとして皮下膿瘍が出現した1例, 第74 回日本結核・非結核性抗酸菌症学会中国四国支部会, 2023年12月.
3.	阿部あかね, 東桃代, 泉侑希, 西岡安彦 : 当院におけるClostridioides difficile検査に対するDiagnostic stewardshipの取り組みの経過報告, 第97回日本感染症学会総会・学術講演会, 2023年4月.
4.	宮本憲哉, 土師恵子, 原田紗希, 鈴江涼子, 阿部あかね, 東桃代, 佐藤正大, 埴淵昌毅, 西岡安彦 : 当院における肺MAC症に対するアジスロマイシン併用療法の有効性・安全性の検討, 第73回日本結核・非結核性抗酸菌症学会中国四国支部会, 2022年12月.
5.	阿部あかね, 東桃代, 岡田直人, 佐藤雅美, 高橋真理, 矢野由美子, 西岡安彦 : 当院における血液培養，Clostridioides difficile検査に対するDiagnostic stewardshipの取り組み, 第70回日本化学療法学会総会, 2022年6月.
6.	村上行人, 原田紗希, 今倉健, 三橋惇志, 小川瑛, 塚崎佑貴, 尾崎領彦, 矢葺洋平, 香川耕造, 米田浩人, 阿部あかね, 荻野広和, 小山壱也, 佐藤正大, 坂口暁, 西岡安彦 : 抗GM-CSF抗体測定が早期診断に有用であった自己免疫性肺胞蛋白症の一例, 第45回日本呼吸器内視鏡学会学術集会, 2022年5月.
7.	今倉健, 佐藤正大, 原田紗希, 三橋惇志, 小川瑛, 村上行人, 塚崎佑貴, 尾崎領彦, 矢葺洋平, 香川耕造, 米田浩人, 阿部あかね, 荻野広和, 坂口暁, 西岡安彦 : 肺門部・縦隔リンパ節腫大に対してEBUS-TBNAを実施し子宮頸癌再発と診断した1例, 第45回日本呼吸器内視鏡学会学術集会, 2022年5月.
8.	花房翠, 矢葺洋平, 今倉健, 米田浩人, 阿部あかね, 美馬正人, 山下雄也, 内藤伸仁, 香川耕造, 大塚憲司, 佐藤正大, 軒原浩, 西岡安彦 : ステロイドパルス療法後に増悪し二度目のパルス療法が奏効したCOVID-19肺炎の1例, 第63回日本呼吸器学会中国・四国地方会, 2021年8月.
9.	阿部あかね, 内藤伸仁, 大塚憲司, 川上行奎, 藤井志朗, 岩本誠司, 佐藤正大, 河野弘, 軒原浩, 西岡安彦 : 非小細胞肺癌に合併した後天性血友病Aの1例, 第123回日本内科学会四国地方会, 2020年11月.