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en: 腎性貧血の新規治療標的 ヘプシジンとエリスロフェロン(今この研究が面白い!2024年9月増大号)

en: 臨床雑誌内科

ja: 臨床雑誌内科


en: [A new attempt of integrated practice of basic medicine in Tokushima University].

ja: 基礎医学における実習統合化の新たな取り組み

en: The Japan Accreditation Council for Medical Education has strengthened the promotion of horizontal and vertical integration of medical education, assuring the quality of medical education in Japan from an international perspective. Pharmacology plays an important role as a central hub that connects basic medical education with clinical medical education. As part of promoting horizontal integration of medical education, Tokushima University has started a joint practice with three basic medical subjects such as Biochemistry, Physiology, and Pharmacology for 2nd grade medical students in 2019. Each subject is in charge of two or four items of practice, and a total 8 of items are performed for 10 days in integrated practice every year. This joint practice has become an official subject in 2022. We introduce our experiences of unique practices based on their advantages and limitations.

en: Folia Pharmacologica Japonica

ja: 日本薬理学雑誌


en: The association between COVID-19 and cardiovascular diseases

ja: COVID - 19と循環器疾患との関連について

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: Roles of histone acetylation sites in cardiac hypertrophy and heart failure.

en: Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure. The development of cardiac hypertrophy and heart failure involves reprogramming of gene expression, a process that is highly dependent on epigenetic regulation. Histone acetylation is dynamically regulated by cardiac stress. Histone acetyltransferases play an important role in epigenetic remodeling in cardiac hypertrophy and heart failure. The regulation of histone acetyltransferases serves as a bridge between signal transduction and downstream gene reprogramming. Investigating the changes in histone acetyltransferases and histone modification sites in cardiac hypertrophy and heart failure will provide new therapeutic strategies to treat these diseases. This review summarizes the association of histone acetylation sites and histone acetylases with cardiac hypertrophy and heart failure, with emphasis on histone acetylation sites.

en: Frontiers in Cardiovascular Medicine

ja: Frontiers in Cardiovascular Medicine


en: The role of iron in obesity and diabetes.

en: Iron is an essential trace metal for all life, but excess iron causes oxidative stress through catalyzing the toxic hydroxy-radical production via the Fenton reaction. The number of patients with obesity and diabetes has been increasing worldwide, and their onset and development are affected by diet. In both clinical and experimental studies, a high body iron content was associated with obesity and diabetes, and the reduction of body iron content to an appropriate level can ameliorate the status and development of obesity and diabetes. Macrophages play an essential role in the pathophysiology of obesity and diabetes, and in the metabolism and homeostasis of iron in the body. Recent studies demonstrated that macrophage polarization is related to adipocyte hypertrophy and insulin resistance through their capabilities of iron handling. Control of iron in macrophages is a potential therapeutic strategy for obesity and diabetes. J. Med. Invest. 69 : 1-7, February, 2022.

en: The Journal of Medical Investigation : JMI


en: Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases.

en: European Cardiology

ja: European Cardiology


en: [Noble Heart Failure Therapy Using Food Compositions].

en: Journal of the Pharmaceutical Society of Japan


en: Creation of a treatment for renal aging by targeting macrophage iron metabolism alterations

ja: マクロファージ鉄代謝変容を標的とした人老化に対する治療法の創出

en: Research Report of Takeda Medical Research Foundation

ja: 代謝異常治療研究基金研究業績集

misc_type: others