=== Generating (published_papers) ===
=== Generating (research_interests) ===
=== Generating (teaching_experience) ===
=== Generating (misc) ===
=== Generating (research_projects) ===
=== Generating (presentations) ===
==== begin registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/published_papers.jsonl) ====
line:1, {"insert":{"user_id":"6000007612","type":"published_papers","id":"50705876"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/40397512","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=445853","label":"url"}],"paper_title":{"en":"Voclosporin Overdose-Induced Peroxisomal Structural Changes and AKI Are Prevented By Renal Indole Detoxifier, INMT.","ja":"Voclosporin Overdose-Induced Peroxisomal Structural Changes and AKI Are Prevented By Renal Indole Detoxifier, INMT."},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Sakamaki Yusuke"},{"name":"Tamaki Masanori"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"Sakamaki Yusuke"},{"name":"田蒔 昌憲"},{"name":"𦚰野 修"}]},"publication_date":"2025-05-21","publication_name":{"en":"Journal of the American Society of Nephrology","ja":"Journal of the American Society of Nephrology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1681/ASN.0000000751"],"issn":["1533-3450"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/39796581","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85214514845&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=418513","label":"url"}],"paper_title":{"en":"Ghrelin Promotes Lipid Uptake into White Adipose Tissue via Endothelial Growth Hormone Secretagogue-Receptor in Mice","ja":"Ghrelin Promotes Lipid Uptake into White Adipose Tissue via Endothelial Growth Hormone Secretagogue-Receptor in Mice"},"authors":{"en":[{"name":"Urai Hidenori"},{"name":"Azegami Tatsuhiko"},{"name":"Komatsu Motoaki"},{"name":"Takahashi Rina"},{"name":"Kubota Yoshiaki"},{"name":"Hasegawa Kazuhiro"},{"name":"Tokuyama Hirofumi"},{"name":"Wakino Shu"},{"name":"Hayashi Kaori"},{"name":"Kanda Takeshi"},{"name":"Itoh Hiroshi"}],"ja":[{"name":"Urai Hidenori"},{"name":"Azegami Tatsuhiko"},{"name":"Komatsu Motoaki"},{"name":"Takahashi Rina"},{"name":"Kubota Yoshiaki"},{"name":"長谷川 一宏"},{"name":"Tokuyama Hirofumi"},{"name":"Wakino Shu"},{"name":"Hayashi Kaori"},{"name":"Kanda Takeshi"},{"name":"Itoh Hiroshi"}]},"description":{"en":"Background/Objectives: Endothelial peroxisome proliferator-activated receptor gamma (PPARγ) regulates adipose tissue by facilitating lipid uptake into white adipocytes, but the role of endothelial lipid transport in systemic energy balance remains unclear. Ghrelin conveys nutritional information through the central nervous system and increases adiposity, while deficiency in its receptor, growth hormone secretagogue-receptor (GHSR), suppresses adiposity on a high-fat diet. This study aims to examine the effect of ghrelin/GHSR signaling in the endothelium on lipid metabolism. Methods: We compared the effects of ghrelin on adiposity and lipid uptake into adipocytes in wild-type and GHSR-null mice. Transgenic mice expressing GHSR selectively in endothelial cells were also generated and compared with global GHSR-null and wild-type mice. The impact of ghrelin on lipid uptake-related genes was assessed in cultured endothelial cells. Results: Ghrelin increased adiposity and triglyceride clearance in wild-type but not in GHSR-null mice. GHSR-null mice showed higher serum triglyceride after olive oil gavage and lower white adipose tissue (WAT) weight on a high-fat diet, suggesting impaired lipid uptake. Restoring GHSR expression in endothelial cells increased lipoprotein lipase activity, lipid uptake into WAT, and WAT weight. Ghrelin enhanced free fatty acid uptake and the expression of lipid uptake genes in cultured endothelial cells, whereas these effects were absent in GHSR-null mice-derived endothelial cells. Knockdown of PPARγ revealed that ghrelin/GHSR signaling in endothelial cells promoted lipid uptake via endothelial PPARγ. Conclusions: Endothelial GHSR is key for regulating lipid metabolism via PPARγ in response to ghrelin and for the role of endothelium in regulating white adipocyte metabolism. Targeting endothelial ghrelin signaling may be a promising therapeutic approach for managing excessive adiposity and associated metabolic disorders.","ja":"Background/Objectives: Endothelial peroxisome proliferator-activated receptor gamma (PPARγ) regulates adipose tissue by facilitating lipid uptake into white adipocytes, but the role of endothelial lipid transport in systemic energy balance remains unclear. Ghrelin conveys nutritional information through the central nervous system and increases adiposity, while deficiency in its receptor, growth hormone secretagogue-receptor (GHSR), suppresses adiposity on a high-fat diet. This study aims to examine the effect of ghrelin/GHSR signaling in the endothelium on lipid metabolism. Methods: We compared the effects of ghrelin on adiposity and lipid uptake into adipocytes in wild-type and GHSR-null mice. Transgenic mice expressing GHSR selectively in endothelial cells were also generated and compared with global GHSR-null and wild-type mice. The impact of ghrelin on lipid uptake-related genes was assessed in cultured endothelial cells. Results: Ghrelin increased adiposity and triglyceride clearance in wild-type but not in GHSR-null mice. GHSR-null mice showed higher serum triglyceride after olive oil gavage and lower white adipose tissue (WAT) weight on a high-fat diet, suggesting impaired lipid uptake. Restoring GHSR expression in endothelial cells increased lipoprotein lipase activity, lipid uptake into WAT, and WAT weight. Ghrelin enhanced free fatty acid uptake and the expression of lipid uptake genes in cultured endothelial cells, whereas these effects were absent in GHSR-null mice-derived endothelial cells. Knockdown of PPARγ revealed that ghrelin/GHSR signaling in endothelial cells promoted lipid uptake via endothelial PPARγ. Conclusions: Endothelial GHSR is key for regulating lipid metabolism via PPARγ in response to ghrelin and for the role of endothelium in regulating white adipocyte metabolism. Targeting endothelial ghrelin signaling may be a promising therapeutic approach for managing excessive adiposity and associated metabolic disorders."},"publication_date":"2024-12","publication_name":{"en":"Nutrients","ja":"Nutrients"},"volume":"17","number":"1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/nu17010146"],"issn":["2072-6643"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"6000007612","type":"published_papers","id":"50705877"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/39370259","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-105004022755&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=437807","label":"url"}],"paper_title":{"en":"Roxadustat for Treating Anemia in Patients with Advanced Chronic Kidney Disease Not Undergoing Dialysis: A Retrospective Study","ja":"Roxadustat for Treating Anemia in Patients with Advanced Chronic Kidney Disease Not Undergoing Dialysis: A Retrospective Study"},"authors":{"en":[{"name":"Tamaki Masanori"},{"name":"Inagaki Taizo"},{"name":"Minato Masanori"},{"name":"Shibata Eriko"},{"name":"Nishioka Rika"},{"name":"Nishioka Satoshi"},{"name":"Matsubara Yukiko"},{"name":"Sasaki Masamitsu"},{"name":"Tamaki Motoyuki"},{"name":"Tamaki Masaharu"},{"name":"Hasegawa Kazuhiro"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}],"ja":[{"name":"Tamaki Masanori"},{"name":"Inagaki Taizo"},{"name":"Minato Masanori"},{"name":"Shibata Eriko"},{"name":"Nishioka Rika"},{"name":"Nishioka Satoshi"},{"name":"Matsubara Yukiko"},{"name":"Sasaki Masamitsu"},{"name":"Tamaki Motoyuki"},{"name":"Tamaki Masaharu"},{"name":"長谷川 一宏"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}]},"description":{"en":"Objective Roxadustat, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, increases the hemoglobin (Hb) levels in patients with chronic kidney disease (CKD). To date, limited clinical studies have focused on the excessive increase in the Hb levels in the early weeks after switching from erythropoiesis-stimulating agents (ESA) to roxadustat in adult non-dialysis patients. We conducted a retrospective study to examine whether early overshoot frequently occurs after switching to roxadustat. Methods This 8-week retrospective pilot study examined patients with anemic, non-dialyzed CKD who switched from ESA (darbepoetin or epoetin beta pegol) to roxadustat or continued ESA. The Hb levels >12.5 g/dL after starting our observation was defined as Hb overshoot. Patients: Twenty-three patients who switched to roxadustat (roxadustat group) and 63 who continued ESA (ESA group) were included. Results The baseline median estimated glomerular filtration rate and mean Hb levels were 15.7 mL/min/1.73 m2 and 10.77 g/dL in roxadustat group and 15.2 mL/min/1.73 m2 and 10.64 g/dL in ESA group, respectively. Eight patients (34.8%) in the roxadustat group and two patients (3.2%) in the ESA group had Hb overshoot within the 8-week visit [odds ratio: 20.2 (95% confidence interval 3.13-130.0, p<0.01) in the background adjusted model]. Among the patients with Hb overshoot in the roxadustat group, the Hb levels were maintained close to baseline 4 weeks after roxadustat discontinuation. A younger age and higher baseline Hb and Hct levels were risk factors for Hb overshoot. Conclusion Hb overshoot was frequently observed in patients switched to roxadustat. Clinicians should be aware of Hb overshoot and emphasize the importance of early Hb level checks.","ja":"Objective Roxadustat, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, increases the hemoglobin (Hb) levels in patients with chronic kidney disease (CKD). To date, limited clinical studies have focused on the excessive increase in the Hb levels in the early weeks after switching from erythropoiesis-stimulating agents (ESA) to roxadustat in adult non-dialysis patients. We conducted a retrospective study to examine whether early overshoot frequently occurs after switching to roxadustat. Methods This 8-week retrospective pilot study examined patients with anemic, non-dialyzed CKD who switched from ESA (darbepoetin or epoetin beta pegol) to roxadustat or continued ESA. The Hb levels >12.5 g/dL after starting our observation was defined as Hb overshoot. Patients: Twenty-three patients who switched to roxadustat (roxadustat group) and 63 who continued ESA (ESA group) were included. Results The baseline median estimated glomerular filtration rate and mean Hb levels were 15.7 mL/min/1.73 m2 and 10.77 g/dL in roxadustat group and 15.2 mL/min/1.73 m2 and 10.64 g/dL in ESA group, respectively. Eight patients (34.8%) in the roxadustat group and two patients (3.2%) in the ESA group had Hb overshoot within the 8-week visit [odds ratio: 20.2 (95% confidence interval 3.13-130.0, p<0.01) in the background adjusted model]. Among the patients with Hb overshoot in the roxadustat group, the Hb levels were maintained close to baseline 4 weeks after roxadustat discontinuation. A younger age and higher baseline Hb and Hct levels were risk factors for Hb overshoot. Conclusion Hb overshoot was frequently observed in patients switched to roxadustat. Clinicians should be aware of Hb overshoot and emphasize the importance of early Hb level checks."},"publication_date":"2024-10-17","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"64","number":"9","starting_page":"1303","ending_page":"1314","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.3773-24"],"issn":["0918-2918"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2012210","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38928090","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410124","label":"url"}],"paper_title":{"en":"Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.","ja":"Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1."},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Sakamaki Yusuke"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"Sakamaki Yusuke"},{"name":"𦚰野 修"}]},"description":{"en":"overexpression preserved mitoribosomal function, suggesting its protective role in DN.","ja":"overexpression preserved mitoribosomal function, suggesting its protective role in DN."},"publication_date":"2024-06-09","publication_name":{"en":"International Journal of Molecular Sciences","ja":"International Journal of Molecular Sciences"},"volume":"25","number":"12","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/ijms25126384"],"issn":["1422-0067"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:5, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2012209","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38587753","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85189697626&origin=inward","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85196749614&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410122","label":"url"}],"paper_title":{"en":"Ability of NAD and Sirt1 to epigenetically suppress albuminuria.","ja":"Ability of NAD and Sirt1 to epigenetically suppress albuminuria."},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Shibata Eriko"},{"name":"Inagaki Taizo"},{"name":"Minato Masanori"},{"name":"Yamaguchi Sumiyo"},{"name":"Shimizu Ikuko"},{"name":"Miyakami Shinji"},{"name":"Tada Miho"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"柴田 恵理子"},{"name":"稲垣 太造"},{"name":"湊 将典"},{"name":"Yamaguchi Sumiyo"},{"name":"清水 郁子"},{"name":"Miyakami Shinji"},{"name":"多田 美穂"},{"name":"𦚰野 修"}]},"description":{"en":"The time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites to reduce albuminuria through Sirt1- or Nampt-dependent epigenetic regulation. We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed glomerular Sirt1 was found to epigenetically elevate Claudin-1. In addition, we reported that proximal tubular Nampt deficiency epigenetically augmented TIMP-1 levels in Sirt6-mediated pathways, leading to type-IV collagen deposition and diabetic fibrosis. Altogether, we propose that the Sirt1/Claudin-1 axis may be crucial in the onset of albuminuria at the early stages of DN and that the Nampt/Sirt6/TIMP-1 axis promotes diabetic fibrosis in the middle to late stages of DN. Finally, administration of NMN, an NAD precursor, epigenetically potentiates the regression of the onset of DN to maintain Sirt1 and repress Claudin-1 in podocytes, suggesting the potential use of NAD metabolites as epigenetic medications for DN.","ja":"The time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites to reduce albuminuria through Sirt1- or Nampt-dependent epigenetic regulation. We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed glomerular Sirt1 was found to epigenetically elevate Claudin-1. In addition, we reported that proximal tubular Nampt deficiency epigenetically augmented TIMP-1 levels in Sirt6-mediated pathways, leading to type-IV collagen deposition and diabetic fibrosis. Altogether, we propose that the Sirt1/Claudin-1 axis may be crucial in the onset of albuminuria at the early stages of DN and that the Nampt/Sirt6/TIMP-1 axis promotes diabetic fibrosis in the middle to late stages of DN. Finally, administration of NMN, an NAD precursor, epigenetically potentiates the regression of the onset of DN to maintain Sirt1 and repress Claudin-1 in podocytes, suggesting the potential use of NAD metabolites as epigenetic medications for DN."},"publication_date":"2024-04-08","publication_name":{"en":"Clinical and Experimental Nephrology","ja":"Clinical and Experimental Nephrology"},"volume":"28","number":"7","starting_page":"599","ending_page":"607","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10157-024-02502-w"],"issn":["1437-7799"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:6, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37199399","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400706","label":"url"}],"paper_title":{"en":"PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models.","ja":"PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models."},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Sakamaki Yusuke"},{"name":"Tamaki Masanori"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"Sakamaki Yusuke"},{"name":"田蒔 昌憲"},{"name":"𦚰野 修"}]},"description":{"en":"PCK1 preserves mitoribosomal function and may play a novel protective role in DN.","ja":"PCK1 preserves mitoribosomal function and may play a novel protective role in DN."},"publication_date":"2023-05-18","publication_name":{"en":"Journal of the American Society of Nephrology","ja":"Journal of the American Society of Nephrology"},"volume":"34","number":"8","starting_page":"1343","ending_page":"1365","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1681/ASN.0000000000000156"],"issn":["1533-3450"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:7, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33795425","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85107319498&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=421556","label":"url"}],"paper_title":{"en":"Pre-emptive short-term nicotinamide mononucleotide treatment in a mouse model of diabetic nephropathy","ja":"Pre-emptive short-term nicotinamide mononucleotide treatment in a mouse model of diabetic nephropathy"},"authors":{"en":[{"name":"Yasuda Itaru"},{"name":"Hasegawa Kazuhiro"},{"name":"Sakamaki Yusuke"},{"name":"Muraoka Hirokazu"},{"name":"Kawaguchi Takahisa"},{"name":"Kusahana Ei"},{"name":"Ono Takashi"},{"name":"Kanda Takeshi"},{"name":"Tokuyama Hirobumi"},{"name":"Wakino Shu"},{"name":"Itoh Hiroshi"}],"ja":[{"name":"Yasuda Itaru"},{"name":"長谷川 一宏"},{"name":"Sakamaki Yusuke"},{"name":"Muraoka Hirokazu"},{"name":"Kawaguchi Takahisa"},{"name":"Kusahana Ei"},{"name":"Ono Takashi"},{"name":"Kanda Takeshi"},{"name":"Tokuyama Hirobumi"},{"name":"Wakino Shu"},{"name":"Itoh Hiroshi"}]},"description":{"en":"The activation of NAD+-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. Diabetic db/db mice were treated with NMN transiently for 2 weeks and observed for effects on diabetic nephropathy (DN). At 14 weeks after the treatment period, NMN attenuated the increases in urinary albumin excretion in db/db mice without ameliorating hemoglobin A1c levels. Short-term NMN treatment mitigated mesangium expansion and foot process effacement, while ameliorating decreased Sirt1 expression and increased claudin-1 expression in the kidneys of db/db mice. This treatment also improved the decrease in the expression of H3K9me2 and DNMT1. Short-term NMN treatment also increased kidney concentrations of NAD+ and the expression of Sirt1 and nicotinamide phosphoribosyltransferase (Nampt), and it maintained nicotinamide mononucleotide adenyltransferase1 (Nmnat1) expression in the kidneys. In addition, survival rates improved after NMN treatment. Short-term NMN treatment in early-stage DN has remote renal protective effects through the upregulation of Sirt1 and activation of the NAD+ salvage pathway, both of which indicate NMN legacy effects on DN.","ja":"The activation of NAD+-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. Diabetic db/db mice were treated with NMN transiently for 2 weeks and observed for effects on diabetic nephropathy (DN). At 14 weeks after the treatment period, NMN attenuated the increases in urinary albumin excretion in db/db mice without ameliorating hemoglobin A1c levels. Short-term NMN treatment mitigated mesangium expansion and foot process effacement, while ameliorating decreased Sirt1 expression and increased claudin-1 expression in the kidneys of db/db mice. This treatment also improved the decrease in the expression of H3K9me2 and DNMT1. Short-term NMN treatment also increased kidney concentrations of NAD+ and the expression of Sirt1 and nicotinamide phosphoribosyltransferase (Nampt), and it maintained nicotinamide mononucleotide adenyltransferase1 (Nmnat1) expression in the kidneys. In addition, survival rates improved after NMN treatment. Short-term NMN treatment in early-stage DN has remote renal protective effects through the upregulation of Sirt1 and activation of the NAD+ salvage pathway, both of which indicate NMN legacy effects on DN."},"publication_date":"2021-04-01","publication_name":{"en":"Journal of the American Society of Nephrology","ja":"Journal of the American Society of Nephrology"},"volume":"32","number":"6","starting_page":"1355","ending_page":"1370","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1681/ASN.2020081188"],"issn":["1046-6673"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:8, {"insert":{"user_id":"6000007612","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33452384","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85099472433&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=421583","label":"url"}],"paper_title":{"en":"Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells","ja":"Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells"},"authors":{"en":[{"name":"Kawaguchi Takahisa"},{"name":"Hasegawa Kazuhiro"},{"name":"Yasuda Itaru"},{"name":"Muraoka Hirokazu"},{"name":"Umino Hiroyuki"},{"name":"Tokuyama Hirobumi"},{"name":"Hashiguchi Akinori"},{"name":"Wakino Shu"},{"name":"Itoh Hiroshi"}],"ja":[{"name":"Kawaguchi Takahisa"},{"name":"長谷川 一宏"},{"name":"Yasuda Itaru"},{"name":"Muraoka Hirokazu"},{"name":"Umino Hiroyuki"},{"name":"Tokuyama Hirobumi"},{"name":"Hashiguchi Akinori"},{"name":"Wakino Shu"},{"name":"Itoh Hiroshi"}]},"description":{"en":"Diabetic nephropathy (DN) is accompanied by characteristic changes in the glomerulus, but little is known about the effect of diabetes on parietal epithelial cells (PECs). In this study, a descriptive analysis of PECs was undertaken in diabetic db/db mice and in diabetic patients. PEC hypertrophy was significantly more prominent in diabetic mice than in nondiabetic mice, and this was evident even at the early stage. Additionally, the number of vacuoles in PECs was markedly increased in diabetic mice, suggesting the presence of cellular injury in PECs in DN. Although rare, binuclear cells were observed in mice with early diabetes. In cultured PECs, a high glucose condition, compared with normal glucose condition, induced cellular hypertrophy and apoptosis. Flow cytometry showed that some PECs in the G0 phase reentered the cell cycle but got arrested in the S phase. Finally, in human diabetic subjects, hypertrophy and vacuolization were observed in the PECs. Our data showed that PECs undergo substantial changes in DN and may participate in rearrangement for differentiation into podocytes.","ja":"Diabetic nephropathy (DN) is accompanied by characteristic changes in the glomerulus, but little is known about the effect of diabetes on parietal epithelial cells (PECs). In this study, a descriptive analysis of PECs was undertaken in diabetic db/db mice and in diabetic patients. PEC hypertrophy was significantly more prominent in diabetic mice than in nondiabetic mice, and this was evident even at the early stage. Additionally, the number of vacuoles in PECs was markedly increased in diabetic mice, suggesting the presence of cellular injury in PECs in DN. Although rare, binuclear cells were observed in mice with early diabetes. In cultured PECs, a high glucose condition, compared with normal glucose condition, induced cellular hypertrophy and apoptosis. Flow cytometry showed that some PECs in the G0 phase reentered the cell cycle but got arrested in the S phase. Finally, in human diabetic subjects, hypertrophy and vacuolization were observed in the PECs. Our data showed that PECs undergo substantial changes in DN and may participate in rearrangement for differentiation into podocytes."},"publication_date":"2021-01-15","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"11","number":"1","starting_page":"1515","ending_page":"1515","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-021-81027-8"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/published_papers.jsonl, Wb1eVJkBoVql3uWrJFKq) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/misc.jsonl) ====
line:1, {"insert":{"user_id":"6000007612","type":"misc","id":"50705878"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390304560096488064/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=445861","label":"url"}],"paper_title":{"en":"特集 内科医に知ってもらいたい シン·腎臓診療 [Chapter 4] 腎臓内科での使い方から学ぶ! 最近よく見るあの薬 RAS阻害薬に続け! 慢性腎臓病におけるARNI·MRAの新展開","ja":"特集 内科医に知ってもらいたい シン·腎臓診療 [Chapter 4] 腎臓内科での使い方から学ぶ! 最近よく見るあの薬 RAS阻害薬に続け! 慢性腎臓病におけるARNI·MRAの新展開"},"authors":{"en":[{"name":"Tamaki Masanori"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"publication_date":"2025-07-01","publication_name":{"en":"Internal Medicine","ja":"臨床雑誌 内科"},"volume":"136","number":"1","starting_page":"83","ending_page":"85","languages":["jpn"],"identifiers":{"doi":["10.15106/j_naika136_83"],"issn":["0022-1961"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"6000007612","type":"misc","id":"50705879"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390023239819007872/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=445863","label":"url"}],"paper_title":{"en":"特集 腎臓とエイジング/アンチエイジング 各論 腎臓の老化のメカニズム サーチュイン遺伝子と腎老化のVORTICE(ヴォルティーチェ)","ja":"特集 腎臓とエイジング/アンチエイジング 各論 腎臓の老化のメカニズム サーチュイン遺伝子と腎老化のVORTICE(ヴォルティーチェ)"},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"𦚰野 修"}]},"publication_date":"2025-06-25","publication_name":{"en":"腎と透析","ja":"腎と透析"},"volume":"98","number":"6","starting_page":"811","ending_page":"816","languages":["jpn"],"identifiers":{"doi":["10.24479/kd.0000001925"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"6000007612","type":"misc","id":"50705880"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/40573072","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-105008907867&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=444731","label":"url"}],"paper_title":{"en":"Kidney-Gut Axis in Chronic Kidney Disease: Therapeutic Perspectives from Microbiota Modulation and Nutrition","ja":"Kidney-Gut Axis in Chronic Kidney Disease: Therapeutic Perspectives from Microbiota Modulation and Nutrition"},"authors":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Minato Masanori"},{"name":"Inagaki Taizo"}],"ja":[{"name":"Wakino Shu"},{"name":"長谷川 一宏"},{"name":"Tamaki Masanori"},{"name":"Minato Masanori"},{"name":"Inagaki Taizo"}]},"description":{"en":"Chronic kidney disease (CKD) has a high prevalence worldwide, with an increasing incidence. One of the mechanisms of CKD progression involves a disordered inter-organ relationship between the kidneys and the intestine, known as the kidney-gut axis. In CKD, two pathological gut conditions-disturbed gut microbiota composition called uremic dysbiosis and leaky gut-contribute to the progression of CKD. Dysbiosis is associated with the increased production of gut-derived uremic toxins, leaky gut, and chronic systemic inflammation, leading to worsening uremia, which in turn aggravates the gut condition. This vicious cycle should be a target of the therapeutic strategy against CKD. The modulation of uremic dysbiosis, including prebiotics, probiotics, and synbiotics, has been a typical treatment approach, although clinical evidence for their efficacy has been insufficient. Some non-antibiotic drugs have an impact on human gut bacteria that are believed to play a role in their clinical efficacy on kidney function. Nutrition therapies, including a low-protein diet, dietary fiber, a Mediterranean diet, and whole grains, positively influence gut microbiota composition and have been linked to a decreased risk of CKD. Novel strategies are currently being explored, involving the use of postbiotics, microbiome sequencing techniques, and fecal microbiota transplantation, although clinical application remains to be tested. Human trials investigating the above-mentioned interventions remain inconclusive due to several limitations, including dietary variability and genetic factors. Future research should focus on the development of more effective probiotics, prebiotics, and microbial metabolism-modifying drugs, not only for CKD but for other systemic diseases as well.","ja":"Chronic kidney disease (CKD) has a high prevalence worldwide, with an increasing incidence. One of the mechanisms of CKD progression involves a disordered inter-organ relationship between the kidneys and the intestine, known as the kidney-gut axis. In CKD, two pathological gut conditions-disturbed gut microbiota composition called uremic dysbiosis and leaky gut-contribute to the progression of CKD. Dysbiosis is associated with the increased production of gut-derived uremic toxins, leaky gut, and chronic systemic inflammation, leading to worsening uremia, which in turn aggravates the gut condition. This vicious cycle should be a target of the therapeutic strategy against CKD. The modulation of uremic dysbiosis, including prebiotics, probiotics, and synbiotics, has been a typical treatment approach, although clinical evidence for their efficacy has been insufficient. Some non-antibiotic drugs have an impact on human gut bacteria that are believed to play a role in their clinical efficacy on kidney function. Nutrition therapies, including a low-protein diet, dietary fiber, a Mediterranean diet, and whole grains, positively influence gut microbiota composition and have been linked to a decreased risk of CKD. Novel strategies are currently being explored, involving the use of postbiotics, microbiome sequencing techniques, and fecal microbiota transplantation, although clinical application remains to be tested. Human trials investigating the above-mentioned interventions remain inconclusive due to several limitations, including dietary variability and genetic factors. Future research should focus on the development of more effective probiotics, prebiotics, and microbial metabolism-modifying drugs, not only for CKD but for other systemic diseases as well."},"publication_date":"2025-06-09","publication_name":{"en":"Nutrients","ja":"Nutrients"},"volume":"17","number":"12","languages":["eng"],"identifiers":{"doi":["10.3390/nu17121961"],"issn":["2072-6643"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"6000007612","type":"misc","id":"50705881"},"force":{"see_also":[{"@id":"https://search.jamas.or.jp/link/ui/2025003329","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390019756116549632/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=445865","label":"url"}],"paper_title":{"en":"特集 今この研究が面白い! 第10章 腎臓 [尿細管代謝]尿細管エネルギー代謝の全貌","ja":"特集 今この研究が面白い! 第10章 腎臓 [尿細管代謝]尿細管エネルギー代謝の全貌"},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"publication_date":"2024-09-01","publication_name":{"en":"Internal Medicine","ja":"臨床雑誌 内科"},"volume":"134","number":"3","starting_page":"760","ending_page":"765","languages":["jpn"],"identifiers":{"doi":["10.15106/j_naika134_760"],"issn":["0022-1961"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:5, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390299528381041664/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410125","label":"url"}],"paper_title":{"en":"特集 糖尿病性腎症研究の最前線 糖尿病性腎症の発症機序 糖尿病性腎症におけるミトコンドリアの役割","ja":"特集 糖尿病性腎症研究の最前線 糖尿病性腎症の発症機序 糖尿病性腎症におけるミトコンドリアの役割"},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Shibata Eriko"},{"name":"Minato Masanori"},{"name":"Inagaki Taizo"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"宮上 慎司"},{"name":"多田 美穂"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"柴田 恵理子"},{"name":"湊 将典"},{"name":"稲垣 太造"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"宮上 慎司"},{"name":"多田 美穂"},{"name":"𦚰野 修"}]},"publication_date":"2024-02-25","publication_name":{"en":"Kidney and Dialysis","ja":"腎と透析"},"volume":"96","number":"2","starting_page":"159","ending_page":"164","languages":["jpn"],"invited":true,"identifiers":{"doi":["10.24479/kd.0000001187"],"issn":["0385-2156"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:6, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390862168254226944/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410126","label":"url"}],"paper_title":{"en":"特集 血液透析患者の血圧を再考する 5.透析患者の至適血圧-腹膜透析も含む","ja":"特集 血液透析患者の血圧を再考する 5.透析患者の至適血圧-腹膜透析も含む"},"authors":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Shibata Eriko"}],"ja":[{"name":"𦚰野 修"},{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"柴田 恵理子"}]},"publication_date":"2024-02-10","publication_name":{"en":"The Japanese Journal of Clinical Dialysis","ja":"臨床透析"},"volume":"40","number":"2","starting_page":"155","ending_page":"163","languages":["jpn"],"identifiers":{"doi":["10.19020/cd.0000002887"],"issn":["0910-5808"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:7, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://search.jamas.or.jp/link/ui/2023126589","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1520013962704009344/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401012","label":"url"}],"paper_title":{"en":"近位尿細管から見た糖尿病性腎臓病と肥満関連腎症","ja":"近位尿細管から見た糖尿病性腎臓病と肥満関連腎症"},"authors":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"}],"ja":[{"name":"𦚰野 修"},{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"}]},"publication_date":"2023-02","publication_name":{"en":"Cardioangiology","ja":"循環器内科"},"volume":"93","number":"2","starting_page":"182","ending_page":"189","languages":["jpn"],"identifiers":{"issn":["1884-2909"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:8, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390016195131521024/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400712","label":"url"}],"paper_title":{"en":"【急性腎障害(AKI)】AKIの病態とその対応 手術とAKI","ja":"【急性腎障害(AKI)】AKIの病態とその対応 手術とAKI"},"authors":{"en":[{"name":"Tamaki Masanori"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"publication_date":"2023-01-25","publication_name":{"en":"Kidney and Dialysis","ja":"腎と透析"},"volume":"94","number":"1","starting_page":"83","ending_page":"86","languages":["jpn"],"identifiers":{"doi":["10.24479/kd.0000000586"],"issn":["0385-2156"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:9, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1520011108762623872/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401037","label":"url"}],"paper_title":{"en":"【ポドサイトパチー】糖尿病性腎症におけるポドサイト傷害の見える化へ迫る最新論文","ja":"【ポドサイトパチー】糖尿病性腎症におけるポドサイト傷害の見える化へ迫る最新論文"},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"publication_date":"2022-06","publication_name":{"en":"Nephrology","ja":"腎臓内科"},"volume":"15","number":"6","starting_page":"659","ending_page":"664","languages":["jpn"],"identifiers":{"issn":["2435-1903"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:10, {"insert":{"user_id":"6000007612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1520292395539278336/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391084","label":"url"}],"paper_title":{"en":"ミトコンドリアとSIRT1/NMNと腎臓病","ja":"ミトコンドリアとSIRT1/NMNと腎臓病"},"authors":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"坂巻 裕介"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"坂巻 裕介"},{"name":"𦚰野 修"}]},"publication_date":"2022-05","publication_name":{"en":"Nephrology","ja":"腎臓内科"},"volume":"15","number":"5","starting_page":"551","ending_page":"557","languages":["jpn"],"identifiers":{"issn":["2435-1903"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/misc.jsonl, Xb1eVJkBoVql3uWrJVJD) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/presentations.jsonl) ====
line:1, {"insert":{"user_id":"6000007612","type":"presentations","id":"50857958"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=448108","label":"url"}],"presentation_title":{"en":"Roxadustat for treating anemia in patients with advanced chronic kidney disease not undergoing dialysis: a pilot study","ja":"Roxadustat for treating anemia in patients with advanced chronic kidney disease not undergoing dialysis: a pilot study"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"Masaharu Tamaki"},{"name":"Hasegawa Kazuhiro"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"Masaharu Tamaki"},{"name":"長谷川 一宏"},{"name":"長井 幸二郎"},{"name":"𦚰野 修"}]},"event":{"en":"Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT","ja":"Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT"},"publication_date":"2024-09-15","languages":["eng"],"is_international_presentation":true},"priority":"input_data"}
line:2, {"insert":{"user_id":"6000007612","type":"presentations","id":"50705875"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15699465","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-20144366571&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=439788","label":"url"}],"presentation_title":{"en":"Role of Rho-kinase and p27 in angiotensin II-induced vascular injury","ja":"Role of Rho-kinase and p27 in angiotensin II-induced vascular injury"},"presenters":{"en":[{"name":"Kanda Takeshi"},{"name":"Hayashi Koichi"},{"name":"Wakino Shu"},{"name":"Homma Koichiro"},{"name":"Yoshioka Kyoko"},{"name":"Hasegawa Kazuhiro"},{"name":"Sugano Naoki"},{"name":"Tatematsu Satoru"},{"name":"Takamatsu Ichiro"},{"name":"Mitsuhashi Takayuki"},{"name":"Saruta Takao"}],"ja":[{"name":"Kanda Takeshi"},{"name":"Hayashi Koichi"},{"name":"Wakino Shu"},{"name":"Homma Koichiro"},{"name":"Yoshioka Kyoko"},{"name":"長谷川 一宏"},{"name":"Sugano Naoki"},{"name":"Tatematsu Satoru"},{"name":"Takamatsu Ichiro"},{"name":"Mitsuhashi Takayuki"},{"name":"Saruta Takao"}]},"event":{"en":"Hypertension","ja":"Hypertension"},"publication_date":"2005-02-07","languages":["eng"],"description":{"en":"Angiotensin II enhances the development of atherosclerotic lesion in which cellular proliferation and/or migration are critical steps. Although cyclin-dependent kinase inhibitor, p27, and Rho/Rho-kinase pathway have recently been implicated as factors regulating these events cooperatively, their role in vivo has not been fully elucidated. We evaluated the contribution of p27 and Rho-kinase to angiotensin II-induced vascular injury using p27-deficient mice. Two-week angiotensin II (1500 ng/kg per minute SC) infusion elicited similar degrees of elevation in systolic blood pressure in wild-type mice (159+/-5 mm Hg) and p27-deficient mice (157+/-5 mm Hg; P>0.05). Angiotensin II infusion to wild-type mice resulted in increases in the medial thickness of aorta, proliferating cell number, and monocyte/macrophage infiltration within the vasculature. In p27-deficient mice, however, these changes were more prominent than those in wild-type mice. Treatment of wild-type mice with fasudil, a selective Rho-kinase inhibitor, did not alter blood pressure but significantly upregulated p27 expression, decreased medial thickness of aorta, reduced proliferating cell number, and prevented monocyte/macrophage infiltration. These protective effects of fasudil were attenuated in p27-deficient mice. In conclusion, p27 constitutes an important modulator of angiotensin II-induced monocyte/macrophage infiltration and vascular remodeling, which is mediated in part by Rho-kinase stimulation. Inhibition of Rho-kinase activity improves angiotensin II-induced vascular injury through p27-dependent and p27-independent mechanisms.","ja":"Angiotensin II enhances the development of atherosclerotic lesion in which cellular proliferation and/or migration are critical steps. Although cyclin-dependent kinase inhibitor, p27, and Rho/Rho-kinase pathway have recently been implicated as factors regulating these events cooperatively, their role in vivo has not been fully elucidated. We evaluated the contribution of p27 and Rho-kinase to angiotensin II-induced vascular injury using p27-deficient mice. Two-week angiotensin II (1500 ng/kg per minute SC) infusion elicited similar degrees of elevation in systolic blood pressure in wild-type mice (159+/-5 mm Hg) and p27-deficient mice (157+/-5 mm Hg; P>0.05). Angiotensin II infusion to wild-type mice resulted in increases in the medial thickness of aorta, proliferating cell number, and monocyte/macrophage infiltration within the vasculature. In p27-deficient mice, however, these changes were more prominent than those in wild-type mice. Treatment of wild-type mice with fasudil, a selective Rho-kinase inhibitor, did not alter blood pressure but significantly upregulated p27 expression, decreased medial thickness of aorta, reduced proliferating cell number, and prevented monocyte/macrophage infiltration. These protective effects of fasudil were attenuated in p27-deficient mice. In conclusion, p27 constitutes an important modulator of angiotensin II-induced monocyte/macrophage infiltration and vascular remodeling, which is mediated in part by Rho-kinase stimulation. Inhibition of Rho-kinase activity improves angiotensin II-induced vascular injury through p27-dependent and p27-independent mechanisms."},"is_international_presentation":true},"priority":"input_data"}
line:3, {"insert":{"user_id":"6000007612","type":"presentations","id":"50857959"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=448112","label":"url"}],"presentation_title":{"en":"ESAからロキサデュスタットへ切り替えた 保存期CKD症例の解析","ja":"ESAからロキサデュスタットへ切り替えた 保存期CKD症例の解析"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"Shibata Eriko"},{"name":"西岡 里香"},{"name":"西岡 聡"},{"name":"松原 由紀子"},{"name":"Tamaki Motoyuki"},{"name":"田蒔 正治"},{"name":"Hasegawa Kazuhiro"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"柴田 恵理子"},{"name":"西岡 里香"},{"name":"西岡 聡"},{"name":"松原 由紀子"},{"name":"田蒔 基行"},{"name":"田蒔 正治"},{"name":"長谷川 一宏"},{"name":"長井 幸二郎"},{"name":"𦚰野 修"}]},"publication_date":"2024-06-29","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:4, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243894"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=407483","label":"url"}],"presentation_title":{"en":"皮膚虚血・潰瘍病変患者における血中亜鉛濃度の意義","ja":"皮膚虚血・潰瘍病変患者における血中亜鉛濃度の意義"},"presenters":{"en":[{"name":"Wakino Shu"},{"name":"柴田 理恵子"},{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Minato Masanori"},{"name":"Inagaki Taizo"},{"name":"宮上 慎司"},{"name":"多田 美穂"},{"name":"Hashimoto Ichiro"}],"ja":[{"name":"𦚰野 修"},{"name":"柴田 理恵子"},{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"湊 将典"},{"name":"稲垣 太造"},{"name":"宮上 慎司"},{"name":"多田 美穂"},{"name":"橋本 一郎"}]},"event":{"en":"第53回徳島透析療法研究会","ja":"第53回徳島透析療法研究会"},"publication_date":"2023-12-03","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:5, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243895"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1520016184419352832/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=410127","label":"url"}],"presentation_title":{"en":"教育講演 糖尿病性腎臓病の治療の進歩","ja":"教育講演 糖尿病性腎臓病の治療の進歩"},"presenters":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"}],"ja":[{"name":"𦚰野 修"},{"name":"長谷川 一宏"}]},"event":{"en":"日本内科学会雑誌","ja":"日本内科学会雑誌"},"publication_date":"2023-09-10","invited":true,"languages":["jpn"],"promoter":{"en":"東京 : 日本内科学会","ja":"東京 : 日本内科学会"},"is_international_presentation":false},"priority":"input_data"}
line:6, {"insert":{"user_id":"6000007612","type":"presentations","id":"47342512"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=411405","label":"url"}],"presentation_title":{"en":"皮膚潰瘍病変患者における血中亜鉛濃度の意義","ja":"皮膚潰瘍病変患者における血中亜鉛濃度の意義"},"presenters":{"en":[{"name":"Wakino Shu"},{"name":"Shibata Eriko"},{"name":"Minato Masanori"},{"name":"Shimizu Ikuko"},{"name":"Hasegawa Kazuhiro"}],"ja":[{"name":"𦚰野 修"},{"name":"柴田 恵理子"},{"name":"湊 将典"},{"name":"清水 郁子"},{"name":"長谷川 一宏"}]},"event":{"en":"Journal of Japanese Society for Dialysis Therapy","ja":"日本透析医学会雑誌"},"publication_date":"2023-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:7, {"insert":{"user_id":"6000007612","type":"presentations","id":"47342513"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=411401","label":"url"}],"presentation_title":{"en":"AKD(acute kidney disease and disorders)を考える 透析導入阻止のためのAKD治療戦略","ja":"AKD(acute kidney disease and disorders)を考える 透析導入阻止のためのAKD治療戦略"},"presenters":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"}],"ja":[{"name":"𦚰野 修"},{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2023-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:8, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243896"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400928","label":"url"}],"presentation_title":{"en":"心血管内分泌の新知見 尿細管糸球体連関とDKD","ja":"心血管内分泌の新知見 尿細管糸球体連関とDKD"},"presenters":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"𦚰野 修"}]},"event":{"en":"Folia endocrinologica Japonica","ja":"日本内分泌学会雑誌"},"publication_date":"2023-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:9, {"insert":{"user_id":"6000007612","type":"presentations","id":"47342514"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=411410","label":"url"}],"presentation_title":{"en":"長時間のAPDにより至適透析を得た重度の精神発達遅滞を有する一例","ja":"長時間のAPDにより至適透析を得た重度の精神発達遅滞を有する一例"},"presenters":{"en":[{"name":"Minato Masanori"},{"name":"Shimizu Ikuko"},{"name":"Tamaki Masanori"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"湊 将典"},{"name":"清水 郁子"},{"name":"田蒔 昌憲"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Journal of Japanese Society for Dialysis Therapy","ja":"日本透析医学会雑誌"},"publication_date":"2023","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:10, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243897"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401017","label":"url"}],"presentation_title":{"en":"時間空間的ネットワークで考えるDKDの基礎研究 尿細管糸球体クロストークとDKD","ja":"時間空間的ネットワークで考えるDKDの基礎研究 尿細管糸球体クロストークとDKD"},"presenters":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-10","languages":["jpn"],"location":{"en":"Kumamoto","ja":"熊本"},"is_international_presentation":false},"priority":"input_data"}
line:11, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243898"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401016","label":"url"}],"presentation_title":{"en":"ロキサデュスタット投与後に奇異性脳塞栓を発症した1例","ja":"ロキサデュスタット投与後に奇異性脳塞栓を発症した1例"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"宮上 慎司"},{"name":"Shimizu Ikuko"},{"name":"山口 純代"},{"name":"Minato Masanori"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"宮上 慎司"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-10","languages":["jpn"],"location":{"en":"Kumamoto","ja":"熊本"},"is_international_presentation":false},"priority":"input_data"}
line:12, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243899"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401014","label":"url"}],"presentation_title":{"en":"コロナウィルスワクチン後発症した悪性腎硬化症の一例","ja":"コロナウィルスワクチン後発症した悪性腎硬化症の一例"},"presenters":{"en":[{"name":"宮上 慎司"},{"name":"Tamaki Masanori"},{"name":"Shimizu Ikuko"},{"name":"山口 純代"},{"name":"Minato Masanori"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"宮上 慎司"},{"name":"田蒔 昌憲"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-10","languages":["jpn"],"location":{"en":"Kumamoto","ja":"熊本"},"is_international_presentation":false},"priority":"input_data"}
line:13, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243900"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401035","label":"url"}],"presentation_title":{"en":"腎臓病治療に対する新たな切り口 DMミトコンドリア機能改善薬やNADがDKDのみならず腎臓病への切り口となる可能性","ja":"腎臓病治療に対する新たな切り口 DMミトコンドリア機能改善薬やNADがDKDのみならず腎臓病への切り口となる可能性"},"presenters":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"坂巻 裕介"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"坂巻 裕介"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Kobe","ja":"神戸"},"is_international_presentation":false},"priority":"input_data"}
line:14, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243901"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401034","label":"url"}],"presentation_title":{"en":"DKDに立ち向かう-これまでの100年とこれからの未来- DKD基礎研究の歩みと先端医療","ja":"DKDに立ち向かう-これまでの100年とこれからの未来- DKD基礎研究の歩みと先端医療"},"presenters":{"en":[{"name":"Wakino Shu"},{"name":"Hasegawa Kazuhiro"},{"name":"伊藤 裕"}],"ja":[{"name":"𦚰野 修"},{"name":"長谷川 一宏"},{"name":"伊藤 裕"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Kobe","ja":"神戸"},"is_international_presentation":false},"priority":"input_data"}
line:15, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243902"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401033","label":"url"}],"presentation_title":{"en":"NMN消費酵素Nmnatのポドサイト発現調節はE-boxへのepigenetic制御が担う","ja":"NMN消費酵素Nmnatのポドサイト発現調節はE-boxへのepigenetic制御が担う"},"presenters":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"坂巻 裕介"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"坂巻 裕介"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Kobe","ja":"神戸"},"is_international_presentation":false},"priority":"input_data"}
line:16, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243903"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401032","label":"url"}],"presentation_title":{"en":"ESAからロキサデュスタットへ切り替えた保存期CKD症例の解析","ja":"ESAからロキサデュスタットへ切り替えた保存期CKD症例の解析"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"宮上 慎司"},{"name":"Shimizu Ikuko"},{"name":"山口 純代,"},{"name":"Minato Masanori"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Tamaki Motoyuki"},{"name":"Tamaki Motoyuki"},{"name":"Hasegawa Kazuhiro"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"宮上 慎司"},{"name":"清水 郁子"},{"name":"山口 純代,"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"田蒔 基行"},{"name":"田蒔 基行"},{"name":"長谷川 一宏"},{"name":"長井 幸二郎"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:17, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243904"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401031","label":"url"}],"presentation_title":{"en":"FSGSへのNMN短期集中投与はNMN・NAD消費酵素の暴走連関を抑制し糸球体硬化を抑止する","ja":"FSGSへのNMN短期集中投与はNMN・NAD消費酵素の暴走連関を抑制し糸球体硬化を抑止する"},"presenters":{"en":[{"name":"Hasegawa Kazuhiro"},{"name":"Tamaki Masanori"},{"name":"坂巻 裕介"},{"name":"Wakino Shu"}],"ja":[{"name":"長谷川 一宏"},{"name":"田蒔 昌憲"},{"name":"坂巻 裕介"},{"name":"𦚰野 修"}]},"event":{"en":"Japanese Journal of Nephrology","ja":"日本腎臓学会誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Kobe","ja":"神戸"},"is_international_presentation":false},"priority":"input_data"}
line:18, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243905"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401028","label":"url"}],"presentation_title":{"en":"急性間質性腎炎を認めた敗血症性AKIの症例","ja":"急性間質性腎炎を認めた敗血症性AKIの症例"},"presenters":{"en":[{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Tamaki Masanori"},{"name":"Minato Masanori"},{"name":"岩城 真帆"},{"name":"Shimizu Ikuko"},{"name":"山口 純代"},{"name":"宮上 慎司"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"田蒔 昌憲"},{"name":"湊 将典"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"宮上 慎司"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Journal of Japanese Society for Dialysis Therapy","ja":"日本透析医学会雑誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Yokohama","ja":"横浜"},"is_international_presentation":false},"priority":"input_data"}
line:19, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243906"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401026","label":"url"}],"presentation_title":{"en":"腹膜透析導入後に膵癌を発症した1例","ja":"腹膜透析導入後に膵癌を発症した1例"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"Shimizu Ikuko"},{"name":"山口 純代"},{"name":"Minato Masanori"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Nagai Kojiro"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長井 幸二郎"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Journal of Japanese Society for Dialysis Therapy","ja":"日本透析医学会雑誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Yokohama","ja":"横浜"},"is_international_presentation":false},"priority":"input_data"}
line:20, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243907"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401025","label":"url"}],"presentation_title":{"en":"慢性大動脈解離に伴う慢性DICのため腎代替療法導入に苦慮した1例","ja":"慢性大動脈解離に伴う慢性DICのため腎代替療法導入に苦慮した1例"},"presenters":{"en":[{"name":"Shimizu Ikuko"},{"name":"Tamaki Masanori"},{"name":"宮上 慎司"},{"name":"山口 純代"},{"name":"Minato Masanori"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"清水 郁子"},{"name":"田蒔 昌憲"},{"name":"宮上 慎司"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"Journal of Japanese Society for Dialysis Therapy","ja":"日本透析医学会雑誌"},"publication_date":"2022-05","languages":["jpn"],"location":{"en":"Yokohama","ja":"横浜"},"is_international_presentation":false},"priority":"input_data"}
line:21, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243908"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391093","label":"url"}],"presentation_title":{"en":"膵癌を合併した腹膜透析患者の1例","ja":"膵癌を合併した腹膜透析患者の1例"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Nagai Kojiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"湊 将典"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"長井 幸二郎"},{"name":"𦚰野 修"}]},"event":{"en":"第27回日本腹膜透析医学会学術集会・総会","ja":"第27回日本腹膜透析医学会学術集会・総会"},"publication_date":"2021-10-30","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:22, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243909"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391090","label":"url"}],"presentation_title":{"en":"ステントグラフト留置術がAVG頻回閉塞に有用であった一例","ja":"ステントグラフト留置術がAVG頻回閉塞に有用であった一例"},"presenters":{"en":[{"name":"Tamaki Masanori"},{"name":"湊 将典"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"田蒔 昌憲"},{"name":"湊 将典"},{"name":"宮上 慎司"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"第55回四国透析療法研究会","ja":"第55回四国透析療法研究会"},"publication_date":"2021-10-17","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:23, {"insert":{"user_id":"6000007612","type":"presentations","id":"47243910"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391088","label":"url"}],"presentation_title":{"en":"膜性腎症に合併したIgG4関連腎臓病の一例","ja":"膜性腎症に合併したIgG4関連腎臓病の一例"},"presenters":{"en":[{"name":"遠藤 理子"},{"name":"宮上 慎司"},{"name":"湊 将典"},{"name":"Tamaki Masanori"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"Ueda Sayo"},{"name":"Shibata Eriko"},{"name":"Hasegawa Kazuhiro"},{"name":"Wakino Shu"}],"ja":[{"name":"遠藤 理子"},{"name":"宮上 慎司"},{"name":"湊 将典"},{"name":"田蒔 昌憲"},{"name":"岩城 真帆"},{"name":"清水 郁子"},{"name":"山口 純代"},{"name":"上田 紗代"},{"name":"柴田 恵理子"},{"name":"長谷川 一宏"},{"name":"𦚰野 修"}]},"event":{"en":"第263回徳島医学会","ja":"第263回徳島医学会"},"publication_date":"2021-08-29","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/376686/researchmap/presentations.jsonl, Yb1eVJkBoVql3uWrJVL_) ====
====== BulkResult(6000007612, Wb1eVJkBoVql3uWrJFKq) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:39Z","end_datetime":"2025-09-16T21:48:39Z","estimated_end_datetime":"2025-09-16T21:48:40Z","total_items":8}

--- success
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:39Z","end_datetime":"2025-09-16T21:48:39Z","estimated_end_datetime":"2025-09-16T21:48:40Z","total_items":8}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"50705876","link":"https://api.researchmap.jp/read0137466/published_papers/50705876","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705876]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"49375498","link":"https://api.researchmap.jp/read0137466/published_papers/49375498","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=49375498]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"50705877","link":"https://api.researchmap.jp/read0137466/published_papers/50705877","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705877]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"47229593","link":"https://api.researchmap.jp/read0137466/published_papers/47229593","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229593]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"47229595","link":"https://api.researchmap.jp/read0137466/published_papers/47229595","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229595]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"47229596","link":"https://api.researchmap.jp/read0137466/published_papers/47229596","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229596]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"47229608","link":"https://api.researchmap.jp/read0137466/published_papers/47229608","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229608]。"}]}
{"no":1,"line":8,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"47229609","link":"https://api.researchmap.jp/read0137466/published_papers/47229609","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229609]。"}]}
====== BulkResult(6000007612, Wb1eVJkBoVql3uWrJFKq) : End ======
====== BulkResult(6000007612, Xb1eVJkBoVql3uWrJVJD) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:49Z","end_datetime":"2025-09-16T21:48:49Z","estimated_end_datetime":"2025-09-16T21:48:50Z","total_items":10}

--- success
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:49Z","end_datetime":"2025-09-16T21:48:49Z","estimated_end_datetime":"2025-09-16T21:48:50Z","total_items":10}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"50705878","link":"https://api.researchmap.jp/read0137466/misc/50705878","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705878]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"50705879","link":"https://api.researchmap.jp/read0137466/misc/50705879","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705879]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"50705880","link":"https://api.researchmap.jp/read0137466/misc/50705880","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705880]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"50705881","link":"https://api.researchmap.jp/read0137466/misc/50705881","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705881]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229863","link":"https://api.researchmap.jp/read0137466/misc/47229863","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229863]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229704","link":"https://api.researchmap.jp/read0137466/misc/47229704","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229704]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229697","link":"https://api.researchmap.jp/read0137466/misc/47229697","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229697]。"}]}
{"no":1,"line":8,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229699","link":"https://api.researchmap.jp/read0137466/misc/47229699","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229699]。"}]}
{"no":1,"line":9,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229689","link":"https://api.researchmap.jp/read0137466/misc/47229689","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229689]。"}]}
{"no":1,"line":10,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"misc","id":"47229703","link":"https://api.researchmap.jp/read0137466/misc/47229703","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=47229703]。"}]}
====== BulkResult(6000007612, Xb1eVJkBoVql3uWrJVJD) : End ======
====== BulkResult(6000007612, Yb1eVJkBoVql3uWrJVL_) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:44Z","end_datetime":"2025-09-16T21:48:44Z","estimated_end_datetime":"2025-09-16T21:48:45Z","total_items":23}

--- success
{"code":304,"status":"completion","start_datetime":"2025-09-16T21:48:44Z","end_datetime":"2025-09-16T21:48:44Z","estimated_end_datetime":"2025-09-16T21:48:45Z","total_items":23}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"50857958","link":"https://api.researchmap.jp/read0137466/presentations/50857958","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50857958]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"50705875","link":"https://api.researchmap.jp/read0137466/presentations/50705875","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50705875]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"50857959","link":"https://api.researchmap.jp/read0137466/presentations/50857959","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =50857959]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243894","link":"https://api.researchmap.jp/read0137466/presentations/47243894","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243894]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243895","link":"https://api.researchmap.jp/read0137466/presentations/47243895","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243895]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47342512","link":"https://api.researchmap.jp/read0137466/presentations/47342512","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47342512]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47342513","link":"https://api.researchmap.jp/read0137466/presentations/47342513","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47342513]。"}]}
{"no":1,"line":8,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243896","link":"https://api.researchmap.jp/read0137466/presentations/47243896","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243896]。"}]}
{"no":1,"line":9,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47342514","link":"https://api.researchmap.jp/read0137466/presentations/47342514","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47342514]。"}]}
{"no":1,"line":10,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243897","link":"https://api.researchmap.jp/read0137466/presentations/47243897","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243897]。"}]}
{"no":1,"line":11,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243898","link":"https://api.researchmap.jp/read0137466/presentations/47243898","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243898]。"}]}
{"no":1,"line":12,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243899","link":"https://api.researchmap.jp/read0137466/presentations/47243899","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243899]。"}]}
{"no":1,"line":13,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243900","link":"https://api.researchmap.jp/read0137466/presentations/47243900","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243900]。"}]}
{"no":1,"line":14,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243901","link":"https://api.researchmap.jp/read0137466/presentations/47243901","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243901]。"}]}
{"no":1,"line":15,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243902","link":"https://api.researchmap.jp/read0137466/presentations/47243902","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243902]。"}]}
{"no":1,"line":16,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243903","link":"https://api.researchmap.jp/read0137466/presentations/47243903","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243903]。"}]}
{"no":1,"line":17,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243904","link":"https://api.researchmap.jp/read0137466/presentations/47243904","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243904]。"}]}
{"no":1,"line":18,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243905","link":"https://api.researchmap.jp/read0137466/presentations/47243905","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243905]。"}]}
{"no":1,"line":19,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243906","link":"https://api.researchmap.jp/read0137466/presentations/47243906","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243906]。"}]}
{"no":1,"line":20,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243907","link":"https://api.researchmap.jp/read0137466/presentations/47243907","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243907]。"}]}
{"no":1,"line":21,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243908","link":"https://api.researchmap.jp/read0137466/presentations/47243908","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243908]。"}]}
{"no":1,"line":22,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243909","link":"https://api.researchmap.jp/read0137466/presentations/47243909","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243909]。"}]}
{"no":1,"line":23,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"47243910","link":"https://api.researchmap.jp/read0137466/presentations/47243910","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =47243910]。"}]}
====== BulkResult(6000007612, Yb1eVJkBoVql3uWrJVL_) : End ======