7000026096/published_papers/54259120 Megumi Hara Tsuyoshi Hachiya Takuma Furukawa Yuichiro Nishida Keitaro Tanaka Chisato Shimanoe Jun Otonari Hiroaki Ikezaki Kenji Wakai Takashi Matsunaga Hidemi Ito Sayaka Yamamoto Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Yoshifumi Hidaka Takeshi Nishiyama Hiroko Nakagawa Naoyuki Takashima Daisuke Matsui Kiyonori Kuriki Katsuyuki Miura Kenji Matsui Takeshi Watanabe Kengo Watanabe Itsuki Kageyama Masahiro Nakatochi Yukihide Momozawa Rieko Okada Yuriko N Koyanagi Isao Oze Keitaro Matsuo Predictive performance of breast cancer polygenic risk scores from diverse ancestries: a prospective study in Japanese women. BACKGROUND: Polygenic risk scores (PRSes) have emerged as promising tools for stratifying breast cancer risk on the basis of genomic data. However, PRSes developed in one ancestral population may vary in predictive performance when applied to a different population. This study aimed to evaluate the utility of six breast cancer PRSes developed via European and East Asian genome-wide association studies (GWASes) in a Japanese prospective cohort. METHODS: We analysed data from 7,965 women enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, with a mean follow-up of 11.3 years. Six published PRSes were calculated via genome-wide genotype data, and their associations with breast cancer incidence were assessed via Cox proportional hazards models adjusted for age, survey area, and population structure. Hazard ratios (HRs), 95% confidence intervals (CIs), and Harrell's C statistics are reported. RESULTS: Five of the six PRSes were significantly associated with breast cancer risk. The European-derived PRS313_BC demonstrated the highest predictive performance (HR per standard deviation (SD) = 1.64; C statistic = 0.69; P < 0.001), particularly among women diagnosed with breast cancer before 50 years of age. CONCLUSIONS: Despite cross-ancestry differences, a European-derived PRS demonstrated strong predictive value for breast cancer risk in a Japanese population, likely reflecting the scale and optimization of the original GWAS. These findings indicate that GWAS scale and statistical power may currently outweigh ancestry matching in PRS performance. However, large-scale ancestry-specific GWASes remain essential to improve prediction accuracy in East Asian populations. Breast cancer research : BCR 28 1 null null 20260428 10.1186/s13058-026-02256-1 42050630 7000026096/published_papers/52953383 Hiroshi Okumiyama Ryosuke Fujii Mako Nagayoshi Masahiro Nakatochi Yoshiki Tsuboi Koji Suzuki Hiroaki Ikezaki Takuma Furukawa Rieko Okada Shiroh Tanoue Sadao Suzuki Teruhide Koyama Kiyonori Kuriki Naoyuki Takashima Takeshi Watanabe Asahi Hishida Yukihide Momozawa Mika Yageta Sakurai Atsushi Shimizu Kenji Wakai Keitaro Matsuo Integration of polygenic risk score with measured blood pressure reveals hidden risks of cardiovascular disease mortality: A Japanese prospective cohort study. Although previous studies reported that BP PRS is associated with CVD, it is less explored whether BP PRS and BP are jointly associated with CVD, especially among non-European populations. Therefore, we examined joint associations of BP control and BP polygenic risk score (PRS) with CVD mortality in a Japanese population. Data were obtained from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, the multi-centered cohort study with 14 study areas throughout Japan. Of which, we analyzed ~35,000 Japanese individuals (Mean age: 55 years old, Men: 44%) with measured BP data (11,242 and 23,904 participants in subgroup #1 and #2). We developed PRS for systolic blood pressure (SBP) and diastolic blood pressure (DBP) in each subgroup. Participants were followed up from the baseline survey (2005-2014) to the end of 2020. Not elevated BP was defined as SBP ≤ 140 mmHg or DBP ≤ 90 mmHg regardless of antihypertensive medications. During the follow-up period, a total of 381 CVD deaths were observed. Compared with not elevated BP, HRs (95% CI) of CVD mortality were 1.98 (1.37-2.88) for elevated SBP and 2.41 (1.66-3.49) for elevated DBP. Compared to not elevated BP in the lowest PRS tertile, HRs (95% CI) of CVD mortality in the highest PRS tertile were 2.28 (1.17-4.43) for SBP and 3.08 (1.61-5.91) for DBP even though BP was not elevated. These associations in the subgroup #1 were replicated in the subgroup #2. Our findings highlighted the importance of BP PRS to detect a hidden CVD risk strata in addition to laboratory BP measurements. Hypertension research : official journal of the Japanese Society of Hypertension null null 20251224 10.1038/s41440-025-02486-4 41444827 7000026096/published_papers/51857156 Akari Matsuura Takeshi Watanabe Yuka Torii Kahori Kita Taichi Unohara Masashi Ishizu Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Mako Nagayoshi Kenji Wakai Yasufumi Kato Takashi Matsunaga Yuriko N Koyanagi Isao Oze Nobuaki Michihata Yohko Nakamura Chihaya Koriyama Daisaku Nishimoto Sadao Suzuki Takahiro Otani Naoyuki Takashima Etsuko Ozaki Kiyonori Kuriki Naoko Miyagawa Keiko Kondo Takashi Tamura Keitaro Matsuo Nutrient patterns and mortality: results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. BACKGROUND: The consumption of a healthy diet may play an important role in the prevention of noncommunicable diseases (NCDs). Although associations between nutrient patterns and cardiometabolic risk factors or NCDs have been examined, the associations between nutrient patterns and mortality remain unknown. The present study examined the relationships between nutrient patterns and all-cause and cause-specific mortalities in a large Japanese population. METHODS: A prospective cohort analysis was performed on the data of 72,939 participants aged 35-69 years with a mean follow-up of 11.7 years in the Japan Multi-Institutional Collaborative Cohort Study. A factor analysis was applied to the energy-adjusted intakes of 21 nutrients, and 4 nutrient patterns were extracted: Factor 1 (folate, carotene, fiber, vitamin C, potassium, iron, and retinol patterns); Factor 2 (unsaturated fatty acid and vitamin E patterns); Factor 3 (saturated fatty acid, calcium, vitamin B2 and low carbohydrate patterns); and Factor 4 (sodium, protein and vitamin D patterns). A multivariable Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortalities according to the quartiles of nutrient patterns adjusted for potential confounders including age, sex, research site, drinking and smoking habits. RESULTS: During the follow-up period, 3,488 deaths were identified. A higher Factor 1 (folate, carotene, fiber, vitamin C, potassium, iron, and retinol) score was associated with lower all-cause (HR 0.81, 95% CI 0.73-0.90), CVD (HR 0.65, 95% CI 0.49-0.85) and cerebrovascular disease (HR 0.60, 95% CI 0.38-0.96) mortalities. The second lowest quartile group of the Factor 2 (unsaturated fatty acid and vitamin E) score was associated with lower all-cause (HR 0.86, 95% CI 0.79-0.94) and cancer (HR 0.85, 95% CI 0.76-0.95) mortalities. On the other hand, a higher Factor 2 score was associated with greater cerebrovascular disease mortality (HR 1.57, 95% CI 1.03-2.40). CONCLUSIONS: The results of the present study suggest that increased adherence to nutrient patterns rich in folate, carotene, fiber, vitamin C, potassium, iron, and retinol or moderate adherence to unsaturated fatty acids and vitamin E are associated with a decreased risk of mortality in Japanese adults. Nutrition journal null null 20251212 10.1186/s12937-025-01274-7 41382287 7000026096/published_papers/51812813 Yasufumi Kato Takashi Tamura Kenji Wakai Yoko Kubo Rieko Okada Takashi Matsunaga Mako Nagayoshi Nahomi Imaeda Chiho Goto Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Rie Ibusuki Sadao Suzuki Takahiro Otani Yuriko N Koyanagi Hidemi Ito Etsuko Ozaki Isao Watanabe Kiyonori Kuriki Naoyuki Takashima Naoko Miyagawa Sakurako Katsuura-Kamano Takeshi Watanabe Asahi Hishida Keitaro Matsuo Associations of vegetable and fruit consumption with all-cause and cause-specific mortality in the Japanese population: the Japan multi-institutional collaborative cohort study. Nutrition journal null null 20251122 10.1186/s12937-025-01257-8 41275208 7000026096/published_papers/48905769 Taichi Unohara Takeshi Watanabe Kokichi Arisawa Akari Matsuura Kahori Kita Yuka Torii Masashi Ishizu Sakurako Katsuura-Kamano Tien Van Nguyen Jun Otonari Hiroaki Ikezaki Keitaro Tanaka Chisato Shimanoe Mako Nagayoshi Yoko Kubo Takashi Matsunaga Rieko Okada Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takeshi Nishiyama Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Keiko Kondo Takashi Tamura Keitaro Matsuo Dietary acid load and mortality in the Japan Multi-Institutional Collaborative Cohort Study. Abstract <p>Purpose: The impact of diet on the body acid-base balance may be related to the risk of various chronic diseases. This prospective cohort study examined the relationships between the dietary acid load and all-cause and cause-specific mortalities in a large Japanese population. Methods: The data of 74,360 subjects (aged 35-69 years in the baseline survey) in the Japan Multi-Institutional Collaborative Cohort Study were analyzed. The dietary acid load was estimated using the net endogenous acid production (NEAP) score. Cox proportional hazards regression analyses were performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortalities according to the quartiles of the energy-adjusted NEAP score after adjustments for potential confounders. Results: During a mean follow-up of 11.6 years, 3,761 deaths were identified. A higher NEAP score was associated with higher all-cause (HR 1.16, 95% CI 1.04-1.28) and cerebrovascular disease mortality (HR 1.69, 95% CI 1.08-2.65). Sex-stratified analyses showed that the NEAP score was associated with all-cause and cause-specific mortalities, including cerebrovascular disease mortality in male subjects, but not in female subjects. Conclusion: This study suggest that the dietary acid load is associated with all-cause and cause-specific mortalities, including cerebrovascular disease mortality, in Japanese male adults.</p> Springer Science and Business Media LLC Scientific reports 15 1 41297 41297 20251121 10.1038/s41598-025-25081-6 41271855 7000026096/published_papers/51812814 Taichi Unohara Ryosuke Fujii Takeshi Watanabe Akari Matsuura Yuka Torii Kahori Kita Masashi Ishizu Megumi Hara Yuichiro Nishida Mako Nagayoshi Takashi Matsunaga Rieko Okada Yoko Kubo Shiroh Tanoue Yoshifumi Hidaka Takeshi Nishiyama Hiroko Nakagawa-Senda Teruhide Koyama Isao Watanabe Kiyonori Kuriki Naoyuki Takashima Keiko Kondo Masahiro Nakatochi Yukihide Momozawa Takashi Tamura Keitaro Matsuo Coffee intake, genetic variants, and chronic kidney disease: a cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. PURPOSE: The present study aimed to clarify associations between coffee intake and kidney function with consideration of the effect modifications from coffee intake-related genetic polymorphisms. METHODS: This cross-sectional study included 7,468 Japanese participants 35-69 years old (3,953 women: 52.9%) from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Coffee intake was estimated with a self-administered questionnaire. Three coffee intake-related single nucleotide polymorphisms (in AHR [rs4410790], HECTD4 [rs2074356], and CYP1A2 [rs762551]) were selected with reference to previous studies. Estimated glomerular filtration rate (eGFR [ml/min/1.73 m2]) and CKD (defined as eGFR < 60 ml/min/1.73 m2) were determined. RESULTS: In participants with a slow metabolizing genotype of rs4410790, eGFR with higher coffee intake was 1.64 ml/min/1.73 m2 (95% CI 0.29-2.98) lower than with low coffee intake. For a frequent coffee consumer genotype of rs2074356, eGFR in participants with moderate coffee intake was higher than with low coffee intake. For heterozygous-type rs762551, coffee intake was associated with a lower prevalence of CKD (OR: 0.53, 95% CI 0.33-0.83). Moreover, with the frequent coffee consumer genotype of rs2074356, higher coffee intake was associated with a lower prevalence of CKD (OR: 0.27, 95% CI 0.08-0.78). CONCLUSION: Associations of coffee intake with kidney function and CKD may differ across coffee intake-related polymorphisms in Japanese adults. These findings suggest that attention should be paid to heterogeneous associations between coffee intake and kidney function according to genetic polymorphisms. Further longitudinal studies are expected to address causal questions of these associations. European journal of nutrition 64 7 301 301 20251015 10.1007/s00394-025-03819-2 41094118 7000026096/published_papers/51812833 Masashi Ishizu Takeshi Watanabe Yuka Torii Kahori Kita Akari Matsuura Taichi Unohara Sakurako Katsuura-Kamano Hirokazu Uemura Association between coffee and adiponectin according to the obesity status: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan. BACKGROUND AND AIMS: Coffee may contribute to the prevention of metabolic abnormalities in both obese and normal weight Japanese adults. Although evidence suggests a relationship between coffee and serum adiponectin, stratified analyses according to the obesity status have not yet been reported. This cross-sectional study examined the relationship between coffee intake and serum high molecular weight (HMW)-adiponectin, which is the most active form of adiponectin, according to the obesity status. METHODS AND RESULTS: The baseline data of 606 participants (aged 35-69 years) living in Tokushima prefecture in the Japan Multi-Institutional Collaborative Cohort Study were analyzed. Coffee intake was assessed using a questionnaire. Participants were stratified by the presence or absence of obesity (normal weight: BMI<25 kg/m2; obesity: BMI≥25 kg/m2). Multiple linear regression analyses adjusted for potential confounders were performed to examine the association between coffee intake and HMW-adiponectin or other diabetic factors. Coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 1.02, 95 % CI 0.30, 1.74), but not in obese subjects. Moreover, filtered/instant coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 0.93, 95 % CI 0.21, 1.65), but not in obese subjects. CONCLUSION: The present study suggests that coffee intake, particularly filtered/instant coffee, is associated with serum HMW-adiponectin in normal weight Japanese adults. Nutrition, metabolism, and cardiovascular diseases : NMCD 35 9 104103 104103 20250900 10.1016/j.numecd.2025.104103 40425402 7000026096/published_papers/51812815 Takuma Furukawa Megumi Hara Yuichiro Nishida Keitaro Tanaka Chisato Shimanoe Chiharu Iwasaka Jun Otonari Hiroaki Ikezaki Mako Nagayoshi Takashi Tamura Yudai Tamada Rieko Okada Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takahiro Otani Isao Watanabe Satomi Tomida Kiyonori Kuriki Naoyuki Takashima Aya Kadota Masashi Ishizu Takeshi Watanabe Masahiro Nakatochi Yukihide Momozawa Kenji Wakai Keitaro Matsuo Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups. Polygenic risk scores (PRS) are useful for assessing disease risk; however, knowledge about their effectiveness among Asian and other populations is limited. This study aimed to compare the classification accuracy of PRSs for type 2 diabetes (T2D-PRS) developed from different ancestry groups using genotype data from 14,083 Japanese participants. Participants' scores were calculated using T2D-PRS models, and logistic regression analysis and receiver operating characteristic curves were assessed. The odds ratio of diabetes per 1 standard deviation increase in PRS was 2.18 and 1.55 for the Japanese and European T2D-PRSs, respectively. The area under the curve (AUC) for the Japanese T2D-PRS was 0.781, whereas that for the European T2D-PRS was 0.738 (P < 0.001). Additionally, age-stratified analysis showed higher AUCs in younger than older age groups. The PRS developed from matched ancestry populations has high classification accuracy for diabetes and is particularly useful for the early detection of high-risk individuals with diabetes. npj metabolic health and disease 3 1 17 17 20250503 10.1038/s44324-025-00059-0 40603767 7000026096/published_papers/51812816 Naoko Miyagawa Naoyuki Takashima Akiko Harada Aya Kadota Keiko Kondo Katsuyuki Miura Nahomi Imaeda Chiho Goto Jun Otonari Hiroaki Ikezaki Keitaro Tanaka Chisato Shimanoe Mako Nagayoshi Takashi Tamura Yoko Kubo Yasufumi Kato Yuriko N Koyanagi Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Rie Ibusuki Sadao Suzuki Takeshi Nishiyama Etsuko Ozaki Isao Watanabe Kiyonori Kuriki Takeshi Watanabe Masashi Ishizu Asahi Hishida Yoshikuni Kita Kenji Wakai Keitaro Matsuo Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study. AIM: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan. METHODS: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex. RESULTS: During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio=0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes. CONCLUSION: A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period. Journal of atherosclerosis and thrombosis 32 5 596 607 20250501 10.5551/jat.65049 39537182 7000026096/published_papers/51812835 Sayaka Yamamoto Yuriko N Koyanagi Yuji Iwashita Tomohiro Shinozaki Yutaka Fujiwara Noriaki Sakakura Megumi Hara Yuichiro Nishida Jun Otonari Hiroaki Ikezaki Shiroh Tanoue Chihaya Koriyama Yumiko Kasugai Isao Oze Teruhide Koyama Satomi Tomida Nobuaki Michihata Yohko Nakamura Sadao Suzuki Hiroko Nakagawa-Senda Mako Nagayoshi Yoko Kubo Yasufumi Kato Kenji Wakai Takeshi Watanabe Masashi Ishizu Naoyuki Takashima Aya Kadota Yukihide Momozawa Masahiro Nakatochi Takashi Tamura Akio Niimi Hidemi Ito Keitaro Matsuo Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis. Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate whether these loci are associated with lung cancer risk directly or indirectly through changing smoking behavior. Here, we conducted a case-control study (1427 cases and 5595 controls) and a prospective cohort study (128 incident cases in 10 520 subjects). Using mediation analysis, we decomposed the total effect of the lead single nucleotide polymorphism (SNP) at each locus on lung cancer risk into direct and indirect effects. The results of the two studies were pooled using a random-effects model to estimate summary relative risks (RRs) and their 95% confidence intervals (CIs). Two studies showed that: (i) rs78277894 (EPHX2-CLU, G > A) had a protective direct effect (RR: 0.84; 95% CI: 0.77-0.93) on lung cancer risk; and (ii) rs56129017 (CYP2A6, C > T) had carcinogenic direct and indirect effects on lung cancer risk (RR: 1.26; 95% CI: 1.15-1.39 and RR: 1.01; 95% CI: 1.00-1.01, respectively). This mediation analysis revealed that two smoking behavior-related SNPs, EPHX2-CLU rs78277894 and CYP2A6 rs56129017, were associated with lung cancer risk through pathways independent of changing smoking behavior. Our findings may contribute to our understanding of lung carcinogenesis pathways that cannot be addressed by changes in smoking behavior. Carcinogenesis 46 2 null null 20250403 10.1093/carcin/bgaf011 40059777 7000026096/published_papers/48357101 Takeshi Watanabe Tien Van Nguyen Sakurako Katsuura-Kamano Kokichi Arisawa Masashi Ishizu Taichi Unohara Keitaro Tanaka Chisato Shimanoe Mako Nagayoshi Takashi Tamura Yoko Kubo Yasufumi Kato Isao Oze Hidemi Ito Nobuaki Michihata Yohko Nakamura Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Hiroko Nakagawa-Senda Teruhide Koyama Satomi Tomida Kiyonori Kuriki Naoyuki Takashima Akiko Harada Kenji Wakai Keitaro Matsuo The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-Institutional Collaborative Cohort Study. Metabolic phenotypes were defined by classifying subjects according to their BMI (obesity: BMI ≥25 kg/m2; normal weight: BMI <25 kg/m2) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement Criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% CI): 1.17 (1.01-1.36)] and questionnaire-based analyses [HR (95% CI): 1.15 (1.04-1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Cancer research communications 4 11 2986 2997 20241029 10.1158/2767-9764.CRC-24-0249 39470380 7000026096/published_papers/47876741 Ryosuke Fujii Asahi Hishida Masahiro Nakatochi Hiroshi Okumiyama Naoyuki Takashima Yoshiki Tsuboi Koji Suzuki Hiroaki Ikezaki Chisato Shimanoe Yasufumi Kato Takashi Tamura Hidemi Ito Nobuaki Michihata Shiroh Tanoue Sadao Suzuki Kiyonori Kuriki Aya Kadota Takeshi Watanabe Yukihide Momozawa Kenji Wakai Keitaro Matsuo Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population. Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRSSBP and PRSDBP) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20-80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group ( > 90th percentile) were 3.67 for PRSSBP and 2.92 for PRSDBP. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group ( > 80th percentile) compared with the low PRS group (0-80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited. Hypertension research : official journal of the Japanese Society of Hypertension 47 9 2284 2294 20240703 10.1038/s41440-024-01766-9 38961281 7000026096/published_papers/46003129 Zin Wai Htay Nobuyuki Michihata Yohko Nakamura Yoshitaka Hippo Jun Otonari Hiroaki Ikezaki Yuichiro Nishida Chisato Shimanoe Takashi Tamura Mako Nagayoshi Yasufumi Kato Yudai Tamada Asahi Hishida Shiroh Tanoue Daisaku Nishimoto Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Naoko Miyagawa Sakurako Katsuura-Kamano Takeshi Watanabe Kenji Wakai Keitaro Matsuo Dietary diversity and the risk of metabolic syndrome in a Japanese population: An analysis of baseline cross-sectional data from the J-MICC study BACKGROUND: With the increasing burden of metabolic syndrome, it is crucial to focus on lifestyle factors to reduce the risk of metabolic syndrome. OBJECTIVES: This study aims to quantify the associations between dietary diversity and the risk of metabolic syndrome among the Japanese population. METHODS: This study was conducted using baseline data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. The baseline survey was conducted from 2005 to 2014 by recruiting individuals aged 35-69. Information regarding dietary intake and biometric measurements were obtained. Dietary Diversity Score (DDS) was calculated from the data based on the food frequency questionnaire. A multiple logistic regression analysis was conducted to analyze the association between DDS and metabolic syndrome. RESULTS: In total, 75,332 participants were included for analysis. Inverse associations were observed between a high DDS and metabolic syndrome (adjusted odds ratio, 0.83 [95% confidential interval 0.76-0.92]). Likewise, a high DDS was associated with reduced odds of a high body mass index and hypertension. No significant associations were observed between the DDS and serum triglyceride, fasting blood glucose, or high-density lipoprotein cholesterol values. CONCLUSION: The findings of this study emphasize that dietary diversity has inversed associations with metabolic syndrome. Promoting a diverse and balanced diet can be a potential strategy for mitigating the burden of metabolic syndrome. European journal of clinical nutrition 79 11 1106 1113 20240217 10.1101/2024.02.15.24302906 40813466 7000026096/published_papers/48905773 Takahiko Nagamine Takeshi Watanabe The Catastrophic Perception of Pain in Burning Mouth Syndrome May be Associated with Sympathetic Tone as Indicated by the QTc Interval. Innovations in clinical neuroscience 2158-8333 21 1-3 8 9 20240000 38495607 7000026096/published_papers/47857895 Daisaku Nishimoto Rie Ibusuki Ippei Shimoshikiryo Kenichi Shibuya Shiroh Tanoue Chihaya Koriyama Toshiro Takezaki Isao Oze Hidemi Ito Asahi Hishida Takashi Tamura Yasufumi Kato Yudai Tamada Yuichiro Nishida Chisato Shimanoe Sadao Suzuki Takeshi Nishiyama Etsuko Ozaki Satomi Tomida Kiyonori Kuriki Naoko Miyagawa Keiko Kondo Kokichi Arisawa Takeshi Watanabe Hiroaki Ikezaki Jun Otonari Kenji Wakai Keitaro Matsuo Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan. BACKGROUND: Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study. METHODS: Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014. Hazard ratios (HRs) for all-cause mortality and 95% confidence intervals (CIs) were estimated by sex using a Cox proportional hazard model, with adjustment for related factors. Mediation analysis with fat intake as a mediator was also conducted. RESULTS: The mean follow-up period was 11 years and 2,516 people died. Estimated energy and fat intakes according to the Food Frequency Questionnaire were lower in those with awareness of limiting food intake than in those without this awareness. Women with awareness of limiting fat intake showed a significant decrease in mortality risk (HR=0.73; 95% CI, 0.55 to 0.94). Mediation analysis revealed that this association was due to the direct effect of the awareness of limiting fat intake and that the total effect was not mediated by actual fat intake. Awareness of limiting energy or sweets intake was not related to mortality risk reduction. CONCLUSION: Awareness of limiting food intake had a limited effect on reducing all-cause mortality risk. Journal of epidemiology null null 20231104 10.2188/jea.JE20220354 37926519 7000026096/published_papers/42752092 Takashi Tamura Kenji Wakai Yasufumi Kato Yudai Tamada Yoko Kubo Rieko Okada Mako Nagayoshi Asahi Hishida Nahomi Imaeda Chiho Goto Hiroaki Ikezaki Jun Otonari Megumi Hara Keitaro Tanaka Yohko Nakamura Miho Kusakabe Rie Ibusuki Chihaya Koriyama Isao Oze Hidemi Ito Sadao Suzuki Hiroko Nakagawa-Senda Etsuko Ozaki Daisuke Matsui Kiyonori Kuriki Keiko Kondo Naoyuki Takashima Takeshi Watanabe Sakurako Katsuura-Kamano Keitaro Matsuo Dietary carbohydrate and fat intakes and risk of mortality in the Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. BACKGROUND: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risk of mortality. OBJECTIVES: We examined long-term associations of carbohydrate and fat intakes with mortality. METHODS: In this cohort study, 34,893 men and 46,440 women aged 35-69 years (mean body mass index 23.7 and 22.2 kg/m2, respectively) were followed from the baseline survey (2004-2014) to the end of 2017 or 2018. Intakes of carbohydrate, fat, and total energy were estimated using a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for all-cause and cause-specific mortality according to percent energy intakes of carbohydrate and fat. RESULTS: During a mean 8.9 years of follow-up, we identified 2,783 deaths (1,838 men and 945 women). Compared with men who consumed 50%-<55% of energy from carbohydrate, those that consumed <40% carbohydrate energy had a significantly higher risk of all-cause mortality (the multivariable-adjusted HR: 1.59; 95% CI: 1.19-2.12; P-trend = 0.002). Among women with 5 years or longer of follow-up, women with high carbohydrate intake had a higher risk for all-cause mortality; the multivariable-adjusted HR (95% CI) was 1.71 (0.93-3.13) for ≥65% of energy from carbohydrate compared with 50%-<55% (P-trend = 0.005). Men with high fat intake had a higher risk for cancer mortality; the multivariable-adjusted HR (95% CI) for ≥35% was 1.79 (1.11-2.90) compared with 20%-<25%. Fat intake was marginally inversely associated with the risk for all-cause and cancer mortality in women (P-trend = 0.054 and 0.058, respectively). CONCLUSIONS: An unfavorable association with mortality was observed for low carbohydrate intake in men and for high carbohydrate intake in women. High fat intake could be associated with a lower mortality risk in women among Japanese adults with a relatively high carbohydrate intake. The Journal of nutrition 153 8 2352 2368 20230602 10.1016/j.tjnut.2023.05.027 37271417 7000026096/published_papers/41096206 Takeshi Watanabe Kokichi Arisawa Tien Van Nguyen Masashi Ishizu Sakurako Katsuura-Kamano Asahi Hishida Takashi Tamura Yasufumi Kato Rieko Okada Rie Ibusuki Chihaya Koriyama Sadao Suzuki Takahiro Otani Teruhide Koyama Satomi Tomida Kiyonori Kuriki Naoyuki Takashima Naoko Miyagawa Kenji Wakai Keitaro Matsuo Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study BACKGROUND AND AIMS: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. METHODS AND RESULTS: We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m2; obesity: BMI ≥25 kg/m2) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. CONCLUSION: The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults. Elsevier BV Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 33 3 620 630 20230300 10.1016/j.numecd.2022.12.019 36710119 7000026096/published_papers/41452735 Takeshi Watanabe Mette Sieg Sigrid Juhl Lunde Mads Persson Pankaj Taneja Lene Baad-Hansen Maria Pigg Lene Vase Nocebo response in dentistry: A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal. BACKGROUND: The nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments. OBJECTIVE: This meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery. METHODS: A systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE ≥ 1) separately for the active and placebo arms. The proportion of patients with AE ≥ 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated. RESULTS: In 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE ≥ 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE ≥ 1 and drug-related dropouts. CONCLUSION: These results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon. Journal of oral rehabilitation 50 4 332 342 20230117 10.1111/joor.13414 36648379 7000026096/published_papers/49146959 Takuya Sakashita Yasuyuki Nakamura Yoichi Sutoh Atsushi Shimizu Tsuyoshi Hachiya Yayoi Otsuka-Yamasaki Naoyuki Takashima Aya Kadota Katsuyuki Miura Yoshikuni Kita Hiroaki Ikezaki Jun Otonari Keitaro Tanaka Chisato Shimanoe Teruhide Koyama Isao Watanabe Sadao Suzuki Hiroko Nakagawa-Senda Asahi Hishida Takashi Tamura Yasufumi Kato Rieko Okada Kiyonori Kuriki Sakurako Katsuura-Kamano Takeshi Watanabe Shiroh Tanoue Chihaya Koriyama Isao Oze Yuriko N. Koyanagi Yohko Nakamura Miho Kusakabe Masahiro Nakatochi Yukihide Momozawa Kenji Wakai Keitaro Matsuo Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population Diabetology International 2190-1686 14 2 188 198 20230000 10.1007/s13340-023-00618-0 37090135 2-s2.0-85146963005 7000026096/published_papers/40476042 Rintaro Sogawa Chisato Shimanoe Keitaro Tanaka Megumi Hara Yuichiro Nishida Takuma Furukawa Mako Nagayoshi Asahi Hishida Yoko Kubo Yasufumi Kato Isao Oze Hidemi Ito Yohko Nakamura Miho Kusakabe Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takahiro Otani Daisuke Matsui Isao Watanabe Kiyonori Kuriki Naoyuki Takashima Aya Kadota Takeshi Watanabe Kokichi Arisawa Hiroaki Ikezaki Jun Otonari Kenji Wakai Keitaro Matsuo Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study. OBJECTIVE: Findings on the increased mortality risk in individuals with insomnia are inconsistent across studies. Rather than improving insomnia by sleep control, hypnotic use may be one factor in the increased risk of death; however, the effects of hypnotics on mortality remains unclear. This study aimed to examine the association between all-cause mortality and hypnotic use in a large sample, while adjusting for the effects of comorbidities. METHODS: Overall, 92,527 individuals aged 35-69 years were followed up for mortality in the Japan Multi-Institutional Collaborative Cohort Study. Regular use of hypnotics was assessed using a self-administered questionnaire. Since cancer history carries a substantial risk of death and is associated with the treatment of insomnia with hypnotics, participants with a cancer history were excluded. The hazard ratio (HR) and 95% confidence interval (CI) for all-cause mortality related to hypnotic use were estimated using a Cox proportional hazard model with adjustments for covariates including sleeping hours and comorbidities (body mass index, ischemic heart disease, stroke, and diabetes). RESULTS: During the follow-up (mean, 8.4 ± 2.5 years), 1,492 mortalities were recorded, and the prevalence of taking hypnotics was 4.2%. Hypnotic use was associated with significantly greater risk of all-cause mortality, even after adjustment for the covariates (HR, 1.32; 95% CI, 1.07-1.63). The association between hypnotic use and all-cause mortality was robust in males (HR, 1.51; 95% CI, 1.15-1.96), and participants aged <60 years (HR, 1.75; 95% CI, 1.21-2.54). CONCLUSIONS: Our study revealed sex-age specific associations between hypnotic use and all-cause mortality. Sleep medicine 100 410 418 20221200 10.1016/j.sleep.2022.09.020 36240602 7000026096/published_papers/36247139 Takeshi Watanabe Mette Sieg Sigrid Juhl Lunde Pankaj Taneja Lene Baad-Hansen Maria Pigg Lene Vase What is the nocebo effect and does it apply to dentistry? A narrative review. Evidence for the nocebo effect, a phenomenon characterised by suboptimal treatment efficacy, worsening of symptoms, or the occurrence of adverse events caused by an individual's negative treatment expectations, is growing across a multitude of medical fields. Within dentistry, little attention has been paid to patients' negative expectations, despite a number of studies supporting the influence of related factors, such as dental fear and anxiety, on the severity of peri- and post-operative dental pain. Only recently, a small number of commentaries and letters have emerged, urging dentists to recognise the possible existence of nocebo effects in dentistry and its implications for patient care. The present review summarises essential evidence of the nocebo phenomenon especially in relation to pain and drug administration. Subsequently, an overview of the current evidence of the nocebo phenomenon in the dental field is presented. Finally, based on the general knowledge of the nocebo effect, the review indicates fruitful arrays of research into the nocebo effect in dentistry. Journal of oral rehabilitation 49 5 586 591 20220118 10.1111/joor.13306 35043415 7000026096/published_papers/25752500 Kaoru Kawasaki Shiori Sugawara Kazuya Watanabe Chaoli Hong Trang Thi Huyen Tu Takeshi Watanabe Junichiro Sakamoto Norio Yoshino Takayuki Suga Lou Mikuzuki Miho Takenoshita Satoshi Takada Tohru Kurabayashi Akira Toyofuku Differences in the Clinical Characteristics of Persistent Idiopathic Facial Pain (Atypical Odontalgia) Patients with or Without Neurovascular Compression of the Trigeminal Nerve. BACKGROUND: Persistent idiopathic facial pain (PIFP) is the unexplained pain along the territory of the trigeminal nerve, including nonorganic tooth pain called atypical odontalgia (AO). Though PIFP is debilitating to patients' livelihood and well-being, its pathophysiology remains poorly understood. Although neurovascular compression (NVC) of the trigeminal nerve is known to be associated with trigeminal neuralgia (TN), the relationship between NVC and other orofacial pains has not been fully elucidated. METHODS: In this study, we investigated the differences in the characteristics of PIFP (primarily AO) patients in the presence or absence of NVC. A retrospective analysis was performed on data from 121 consecutive patients who had been diagnosed with unilateral PIFP according to the criteria of the International Classification of Headache Disorders (ICHD)-3 and underwent magnetic resonance imaging scans of the head. RESULTS: In the group without NVC, characteristic findings were significant for psychiatric morbidity, somatization, and pain disability, when compared with the group with NVC. Furthermore, the group without NVC exhibited significant headache, noncardiac chest pain, shortness of breath, and pain catastrophizing. CONCLUSIONS: These results suggest that PIFP patients can be divided into two groups: one consistent with a neuropathic pain phenotype when NVC is present and a functional somatic symptom phenotype when presenting without NVC. Our findings may enable a more precise understanding of pathophysiology of PIFP and lead to better treatment strategies. Pain medicine (Malden, Mass.) 21 4 814 821 20200401 10.1093/pm/pnz300 32040150 7000026096/published_papers/35157427 Yojiro Umezaki Motoko Watanabe Yukiko Shinohara Shiori Sugawara Kaoru Kawasaki Trang T H Tu Takeshi Watanabe Takayuki Suga Anna Miura Miho Takenoshita Yusuke Sato Ichiro Minami Jun Oyama Akira Toriihara Tatsuya Yoshikawa Toru Naito Haruhiko Motomura Akira Toyofuku Comparison of Cerebral Blood Flow Patterns in Patients with Phantom Bite Syndrome with Their Corresponding Clinical Features. Background: Phantom bite syndrome (PBS) is characterized by an uncomfortable sensation during occlusion without any evident abnormality. A recent case-control study with single-photon emission computed tomography (SPECT) using 99mTc-ethyl cysteinate dimer could not find the specific features of regional cerebral blood flow (rCBF), which might be due to the heterogeneity of PBS. We analyzed the brain images of PBS corresponding to the clinical features by studying PBS subgroups. Methods: This study contributes to elucidating the pathophysiology of PBS by evaluating regional brain perfusion on SPECT and its clinical features. We performed SPECT using 99mTc-ethyl cysteinate dimer in 44 patients with PBS. The SPECT images were analyzed qualitatively and quantitatively. Results: Asymmetrical rCBF patterns were detected, corresponding to symptom laterality. Patients with PBS with right-side symptoms showed right-side-predominant rCBF asymmetry in the parietal region and left-side-predominant rCBF asymmetry in the thalamus, and vice versa. Moreover, the analysis of the association between rCBF and patient behaviors revealed that patients who blamed their dentists for their symptoms tended to have a symmetrical rCBF pattern. Conclusion: Patients with PBS showed blood flow imbalance in the thalamus and parietal region corresponding to symptom laterality. There are two types of symmetrical and asymmetrical rCBF patterns in the pathophysiology of PBS despite similar clinical manifestations. Neuropsychiatric disease and treatment 16 2277 2284 20200000 10.2147/NDT.S262892 33116526 7000026096/published_papers/25659633 Yukiko Shinohara Yojiro Umezaki Ichiro Minami Motoko Watanabe Anna Miura Lou Mikutsuki Kaoru Kawasaki Shiori Sugawara Tu Thi Hyen Trang Takayuki Suga Takeshi Watanabe Tatsuya Yoshikawa Miho Takenoshita Haruhiko Motomura Akira Toyofuku Comorbid depressive disorders and left-side dominant occlusal discomfort in patients with phantom bite syndrome. BACKGROUND: Phantom bite syndrome (PBS) is characterised by occlusal discomfort without corresponding dental abnormalities. Despite repeated, failed dental treatments, patients with PBS persist in seeking bite correction. PBS has been regarded as a mental disorder. However, we have reported that PBS patients with a dental trigger tend to have less psychiatric history than those without. Hence, the symptoms of PBS cannot be explained by a mental disorder alone, and it is unclear if mental disorders affect occlusal sensation. OBJECTIVE: To elucidate the pathophysiology of PBS, we analysed the dental history, PBS symptom laterality and psychiatric history of patients. METHODS: In this retrospective study, we reviewed outpatients with PBS who presented at our clinic between April 2012 and March 2017. Their medical records were reviewed for demographic data, medical history and laterality of occlusal discomfort. RESULTS: Approximately half of the 199 enrolled patients had bilateral occlusal discomfort. In the others, the side with occlusal discomfort generally tended to be the one that had received dental treatment. There was no significant relationship between the side chiefly affected by occlusal discomfort and whether dental treatment had been received; however, the affected side differed depending on whether the patient had comorbid psychiatric disorders (P = .041). CONCLUSIONS: The distributions of the side with symptoms of PBS were different between those with and without comorbid psychiatric disorders, suggesting that psychiatric disorders might affect occlusal sensation due to a subtle dysfunction in brain areas central to sensory integration. Central dysfunction might play an important role in PBS. Journal of oral rehabilitation 0305-182X 47 1 36 41 20200100 10.1111/joor.12872 31398263 7000026096/published_papers/25659631 Takayuki Suga Miho Takenoshita Takeshi Watanabe Trang Th Tu Lou Mikuzuki Chaoli Hong Kazuhito Miura Tatsuya Yoshikawa Takahiko Nagamine Akira Toyofuku Therapeutic Dose of Amitriptyline for Older Patients with Burning Mouth Syndrome. To assess the therapeutic dose and safety of amitriptyline and the outcome following treatment with amitriptyline among older patients with burning mouth syndrome (BMS).<br /> 187 consecutive patients were prescribed amitriptyline as a first-line medication from April 2016 to September 2018 and followed-up for &gt;1 month. Patients were divided into 3 groups: group 1, 113 patients aged &lt;65 years; group 2, 52 patients aged between 65 and 74 years; and group 3, 22 patients aged 75 years or older. The visual analog scale (VAS), Pain Catastrophizing Scale (PCS), Somatic Symptom Scale-8 (SSS-8), Patient Global Impression of Change (PGIC), and Short-form McGill Pain Questionnaire (SF-MPQ) were used for analysis.<br /> Thirty-two patients (17 in group 1, 10 in group 2, and 5 in group 3) stopped taking amitriptyline due to side effects. There were no differences among the groups with respect to sex; scores of VAS, PCS, and SSS-8; and drop-out ratio. There were no significant differences in the VAS, PCS, and PGIC scores among the groups after 1 month. The mean daily dose after 1 month was 20.4 ± 8.6 mg in group 1, 17.3 ± 8.7 mg in group 2, and 13.2 ± 5.8 mg in group 3; this difference was significant ( Neuropsychiatr Dis Treat 1176-6328 15 3599 3607 20191200 10.2147/NDT.S235669 31920319 7000026096/published_papers/27340500 渡邊 毅 上甲 カユ 中村 明美 櫻庭 佑佳 青田 宥馬 美久月 瑠宇 三浦 和仁 須賀 隆行 篠原 優貴子 竹之下 美穂 渋田 敏詩 高橋 晋 石河 朝子 堤 祐一郎 豊福 明 精神科入院患者の口腔内環境および抗精神病薬副作用 精神疾患を有する患者の歯科治療を安全に行うために (一財)博慈会老人病研究所 未病と抗老化 1347-667X 28 22 26 20191100 7000026096/published_papers/8475817 Takeshi Watanabe 渡邊 毅 Lou Mikuzuki 美久月瑠宇 Kazuhito Miura 三浦和仁 Takayuki Suga 須賀隆行 Takahiko Nagamine 長嶺敬彦 Akira Toyofuku 豊福明 Placebo effect and dental treatment プラセボ効果と歯科治療-Medically Unexplained Oral Symptoms (MUOS)を生じさせないために- Japanese Journal of Psychiatry 最新精神医学 24 3 235 240 20190500 7000026096/published_papers/25659636 Trang T H Tu Anna Miura Yukiko Shinohara Lou Mikuzuki Kaoru Kawasaki Shiori Sugawara Takayuki Suga Takeshi Watanabe Yuma Aota Yojiro Umezaki Miho Takenoshita Akira Toyofuku Pharmacotherapeutic outcomes in atypical odontalgia: determinants of pain relief. There has been considerable research which has focused on clarifying the origin of pain in patients with atypical odontalgia (AO), also known as &quot;idiopathic toothache&quot;, and on identifying effective treatment, but there has been limited success so far. In this study, we assessed the outcomes of treatment and attempted to identify factors that could account for pain remission in patients with AO.<br /> Data for 165 patients diagnosed with AO from June 2015 to August 2017 were retrospectively reviewed. The patients&#039; sex, age, duration of pain, and psychiatric history were collected, along with information on pain intensity, depressive status, and catastrophizing scores. Responses at 4 and 16 weeks from the start of treatment were observed. The associations between potentially associated factors and outcome were investigated using Bayesian model averaging.<br /> &lt;0.001). Four elements, that is, patient sex, depression score at baseline, pain score at 4 weeks, and change in the catastrophizing score, explained 52.5% of the variation in final outcome between individual patients.<br /> Our findings confirm the efficacy of tricyclic antidepressants (TCAs) as a treatment for AO and indicate that other medica J Pain Res 1178-7090 12 831 839 20190200 10.2147/JPR.S188362 30881094 7000026096/published_papers/25659625 Trang T H Tu Miho Takenoshita Hirofumi Matsuoka Takeshi Watanabe Takayuki Suga Yuma Aota Yoshihiro Abiko Akira Toyofuku Current management strategies for the pain of elderly patients with burning mouth syndrome: a critical review. Burning Mouth Syndrome (BMS), a chronic intraoral burning sensation or dysesthesia without clinically evident causes, is one of the most common medically unexplained oral symptoms/syndromes. Even though the clinical features of BMS have been astonishingly common and consistent throughout the world for hundreds of years, BMS remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly BMS patients for whom the disease is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of BMS more difficult. Because the biggest barrier preventing us from finding the core pathophysiology and best therapy for BMS seems to be its heterogeneity, this syndrome remains challenging for clinicians. In this review, we discuss currently hopeful management strategies, including central neuromodulators (Tricyclic Antidepressants - TCAs, Serotonin, and Norepinephrine Reuptake Inhibitors - SNRIs, Selective Serotonin Reuptake Inhibitors - SSRIs, Clonazepam) and solutions for applying non-pharmacology approaches. Moreover, we also emphasize the important role of patient education and anxiety management to improve the patients' quality of life. A combination of optimized medication with a short-term supportive psychotherapeutic approach might be a useful solution. BioPsychoSocial medicine 1751-0759 13 1 1 20190000 10.1186/s13030-019-0142-7 30733824 7000026096/published_papers/17963406 Takeshi Watanabe Takahiko Nagamine Lou Mikuzuki Yuma Aota Takayuku Suga Tu T.H. Trang Kaoru Kawasaki Yukiko Shinohara Miho Takenoshita Akira Toyofuku Changes in Corrected QT Interval may be associated with Clinical Responses in Burning Mouth Syndrome. International Medical Journal 26 1 13 14 20190100 7000026096/published_papers/25659638 Yukiko Shinohara Yojiro Umezaki Motoko Watanabe Anna Miura Lou Mikuzuki Shiori Sugawara Kaoru Kawasaki Takeshi Watanabe Takayuki Suga Miho Takenoshita Yusuke Sato Akira Toyofuku Brain perfusion-based analysis of ``phantom bite syndrome (一社)日本歯科心身医学会 Journal of Psychosomatic Oral Medicine 0913-6681 33 2 75 81 20181200 7000026096/published_papers/17117846 Takayuki Suga Takeshi Watanabe Yuma Aota Takahiko Nagamine Akira Toyofuku Burning mouth syndrome: The challenge of an aging population Geriatrics & Gerontology International 18 12 1649 1650 20181200 10.1111/ggi.13548 7000026096/published_papers/14814143 Takeshi Watanabe Akinori Kimura Hidehito Kuroyanagi Alternative splicing regulator RBM20 and cardiomyopathy Frontiers in Molecular Biosciences 2296-889X 5 NOV null null 20181100 10.3389/fmolb.2018.00105 2-s2.0-85059224721 7000026096/published_papers/13124126 Takeshi Watanabe Takahiko Nagamine Lou Mikuzuki Yuma Aota Takayuki Suga Trang T.H Tu Miho Takenoshita Akira Toyofuku An increase in corrected QT interval may indicate a good clinical response to amitriptyline in female patients with burning mouth syndrome neurology and neurobiology. Neurology and Neurobiology. 1 1 3 20180800 7000026096/published_papers/13124123 Yojiro Umezaki Anna Miura Yukiko Shinohara Lou Mikuzuki Shiori Sugawara Kaoru Kawasaki Trang Th Tu Takeshi Watanabe Takayuki Suga Motoko Watanabe Miho Takenoshita Tatsuya Yoshikawa Akihito Uezato Toru Nishikawa Ken Hoshiko Toru Naito Haruhiko Motomura Akira Toyofuku Clinical characteristics and course of oral somatic delusions: a retrospective chart review of 606 cases in 5 years Informa UK Limited Neuropsychiatr Dis Treat. 1178-2021 14 2057 2065 20180800 10.2147/ndt.s167527 7000026096/published_papers/13124103 渡邊毅 長嶺 敬彦 美久月 瑠宇 川崎 カオル 須賀 隆行 竹之下 美穂 豊福 明 歯科領域における慢性疼痛に対する抗うつ薬の効果と副作用 最新精神医学 23 4 357 362 20180700 7000026096/published_papers/25659647 Trang T. H. Tu Anna Miura Yukiko Shinohara Lou Mikuzuki Kaoru Kawasaki Shiori Sugawara Takayuki Suga Takeshi Watanabe Motoko Watanabe Yojiro Umezaki Tatsuya Yoshikawa Haruhiko Motomura Miho Takenoshita Akira Toyofuku Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences Blackwell Publishing Inc. Pain Practice 1533-2500 18 5 580 586 20180601 10.1111/papr.12647 28972293 2-s2.0-85034663130 7000026096/published_papers/13124115 Trang T. H. Tu Anna Miura Yukiko Shinohara Lou Mikuzuki Kaoru Kawasaki Shiori Sugawara Takayuki Suga Takeshi Watanabe Motoko Watanabe Yojiro Umezaki Tatsuya Yoshikawa Haruhiko Motomura Miho Takenoshita Akira Toyofuku Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences Blackwell Publishing Inc. Pain Practice 1533-2500 18 5 580 586 20180601 10.1111/papr.12647 2-s2.0-85034663130 7000026096/published_papers/15105035 Takeshi Watanabe Kaoru Kawasaki Trang T.H Tu Akira Toyofuku Takahiko Nagamine Amitriptyline increases salivary flow in treatment-resistant burning mouth syndrome: What is the underlying mechanism? Atlas of Science null null 20180400 7000026096/published_papers/13124117 Takeshi Watanabe Kaoru Kawasaki Trang T.H Tu Takayuki Suga Shiori Sugawara Lou Mikuzuki Anna Miura Yukiko Shinohara Tatsuya Yoshikawa Miho Takenoshita Akira Toyofuku Takahiko Nagamine The QTc shortening with amitriptyline may indicate treatment resistance in chronic nonorganic orofacial pain The Japanese Society of Clinical Neuropsychopharmacology Clinical Neuropsychopharmacology and Therapeutics 1884-8826 9 12 14 20180400 10.5234/cnpt.9.12 7000026096/published_papers/13124116 Kaoru Kawasaki Takahiko Nagamine Takeshi Watanabe Takayuki Suga Trang T.H. Tu Shiori Sugawara Lou Mikuzuki Anna Miura Yukiko Shinohara Tatsuya Yoshikawa Miho Takenoshita Akira Toyofuku An increase in salivary flow with amitriptyline may indicate treatment resistance in burning mouth syndrome Wiley-Blackwell Asia-Pacific Psychiatry 1758-5864 e12315 null 20180300 10.1111/appy.12315 7000026096/published_papers/13124114 Anna Miura Trang T.H. Tu Yukiko Shinohara Lou Mikuzuki Kaoru Kawasaki Shiori Sugawara Takayuki Suga Takeshi Watanabe Motoko Watanabe Yojiro Umezaki Tatsuya Yoshikawa Haruhiko Motomura Miho Takenoshita Hidefumi Maeda Akira Toyofuku Psychiatric comorbidities in patients with Atypical Odontalgia Elsevier Inc. Journal of Psychosomatic Research 1879-1360 104 35 40 20180101 10.1016/j.jpsychores.2017.11.001 2-s2.0-85033604675 7000026096/published_papers/13124112 Takeshi Watanabe Shiori Sekine Isao Naguro Yusuke Sekine Hidenori Ichijo Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis JOURNAL OF BIOLOGICAL CHEMISTRY 1083-351X 290 17 10791 10803 20150400 10.1074/jbc.M114.623280 7000026096/published_papers/13124113 Yusuke Sekine Ryo Hatanaka Takeshi Watanabe Naoki Sono Shun-ichiro Iemura Tohru Natsume Erina Kuranaga Masayuki Miura Kohsuke Takeda Hidenori Ichijo The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5 MOLECULAR CELL 1097-4164 48 5 692 704 20121200 10.1016/j.molcel.2012.09.018 7000026096/published_papers/13124092 Yusuke Sekine Shuichi Takagahara Ryo Hatanaka Takeshi Watanabe Haruka Oguchi Takuya Noguchi Isao Naguro Kazuto Kobayashi Makoto Tsunoda Takashi Funatsu Hiroshi Nomura Takeshi Toyoda Norio Matsuki Erina Kuranaga Masayuki Miura Kohsuke Takeda Hidenori Ichijo p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors JOURNAL OF CELL SCIENCE 1477-9137 124 17 3006 3016 20110900 10.1242/jcs.085902 7000026096/published_papers/15142169 渡邊毅 一條秀憲 西頭 英起 神経変性疾患と小胞体ストレス BIO Clinica null null 20110700 7000026096/misc/52730664 上村浩一 上村浩一 釜野桜子 釜野桜子 石津将 石津将 渡邊毅 渡邊毅 日本の中高年女性における出産歴および月経状況と血中尿酸値との関連 日本衛生学雑誌(Web) 1882-6482 80 Supplement null null 20250000 7000026096/misc/52730661 須磨紫乃 釜野桜子 釜野桜子 片岡宏介 渡邊毅 石津将 大豆食品摂取量が全死因死亡・死因別死亡に与える影響:J-MICC Study 日本疫学会学術総会講演集(Web) 35th null null 20250000 7000026096/misc/52730659 上村浩一 釜野桜子 石津将 渡邊毅 月経状況や生殖歴と慢性炎症,インスリン抵抗性や血中アディポネクチン値との関連 日本疫学会学術総会講演集(Web) 35th null null 20250000 7000026096/misc/52730679 釜野桜子 石津将 渡邊毅 出生体重と日本人中高年の不安特性との関連:J-MICC Study徳島地区調査 日本疫学会学術総会講演集(Web) 34th null null 20240000 7000026096/misc/52730674 上村浩一 上村浩一 釜野桜子 石津将 渡邊毅 日本人女性における生殖関連要因と動脈スティフネスとの関連:J-MICC Study徳島地区調査 日本女性医学学会雑誌 2185-8861 32 1 null null 20240000 7000026096/misc/52730667 上村浩一 釜野桜子 石津将 渡邊毅 出産回数や月経状況と動脈スティフネスとの関連:J-MICC Study徳島地区調査 日本公衆衛生学会総会抄録集(CD-ROM) 83rd null null 20240000 7000026096/misc/52730683 釜野桜子 有澤孝吉 石津将 渡邊毅 NGUYEN Van Tien 大豆製品およびイソフラボン摂取量と糖尿病罹患との関連:J-MICC Study 日本疫学会学術総会講演集(Web) 33rd null null 20230000 7000026096/misc/52730681 渡邊毅 有澤孝吉 グエン バンティエン 石津将 釜野桜子 コーヒー摂取と代謝表現型:J-MICC Studyのベースラインデータを用いた横断研究 日本疫学会学術総会講演集(Web) 33rd null null 20230000 7000026096/misc/52601236 竹之下美穂 篠原優貴子 三浦杏奈 美久月瑠宇 川崎カオル 菅原詩織 Trang TU Thi Huyen 須賀隆行 渡邊毅 豊福明 Psychosomatic Approach to Medically Unexplained Oral Symptoms/Syndromes in a Dental School 当分野におけるいわゆる歯科心身症に対する心身医学的アプローチについて 心身医学 0385-0307 58 2 null null 20180000 一般財団法人 博慈会 優秀論文賞 20251100 5th International Conference of the Society for Interdisciplinary Placebo Studies (SIPS) Best Poster Award 20250600 徳島大学 令和6年度医学部優秀教育賞 20250200 一般財団法人 博慈会 優秀臨床レポート賞 20191100