tomo-nori/published_papers/51142151 Tomonori Takahashi Kenya Kusunose Takumi Imai Yutaka Furukawa Taiji Okada Toshiaki Kadokami Yumiko Kanzaki Hisao Matsuda Kei Mizukoshi Keisuke Kida Yuya Matsue Masataka Sata Atsushi Tanaka Koichi Node Impact of early in-hospital initiation of sacubitril/valsartan on left ventricular reverse remodelling in acute heart failure European Heart Journal - Cardiovascular Pharmacotherapy null null 20251104 10.1093/ehjcvp/pvaf061 tomo-nori/published_papers/51139526 Takahashi T Kusunose K Zheng R Yamaguchi N Hirata Y Nishio S Saijo Y Ise T Yamaguchi K Yagi S Yamada H Soeki T Wakatsuki T Sata M Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease. <h4>Background</h4>Some cardiovascular (CV) risk factors, such as hypertension and diabetes mellitus, have been reported to reduce left ventricular (LV) longitudinal strain (LS) even in patients with preserved LV ejection fraction. We hypothesized that multiple CV risk factors might cause changes in myocardial strain. Our study aimed to assess the association between multiple CV risk factors and strain in patients without previous CV disease (CVD).<h4>Methods</h4>We retrospectively evaluated 137 patients without CVD, who underwent echocardiography at our institution between May 2017 and February 2020. They were divided into four groups based on the number of risk factors (group 0: no risk factor, group 1: one risk factor, group 2: two risk factors, and groups 3: three or four risk factors). Risk factors were hypertension, dyslipidemia, diabetes mellitus, and chronic kidney disease. Absolute values of global LS (GLS) and relative apical LS ratio (RALSR) defined using the equation: average apical LS/(average basal LS + average mid LS) and was used as a marker of strain distribution.<h4>Results</h4>Out of 137 patients, group 0 had 35 patients, group 1 had 35 patients, group 2 had 32 patients, and group 3 had 35 patients. GLS was 22.4 ± 2.0%, 21.7 ± 2.1%, 21.3 ± 1.8%, 20.7 ± 2.2%, and RALSR was 0.64 ± 0.06, 0.66 ± 0.06, 0.68 ± 0.08, 0.69 ± 0.07 in groups 0-3, respectively. The one-way ANOVA detected significant differences between groups in GLS (p = 0.005) and RALSR (p = 0.037), respectively. Group 3 had a significantly lower GLS and higher RALSR than group 0 (p < 0.05).<h4>Conclusion</h4>In patients without previous CVD, LS decreased especially from the basal segment as the number of cardiovascular risks increased. The segmental LS may be markers of occult LV dysfunction in patients with CV risk factors. Journal of echocardiography null null 20220513 10.1007/s12574-022-00576-7 35562627 Tomonori Takahashi Kenya Kusunose Shuji Hayashi Natsumi Yamaguchi Sae Morita Yuta Torii Yukina Hirata Masami Yamao Susumu Nisio Yuichiro Okushi Rie Ueno Nao Yamada Hirotsugu Yamada Tetsuzo Wakatsuki Masataka Sata European Association of Cardiovascular Imaging (EACVI) High Score Abstract Award of EuroEcho-Imaging 2019 Updated Prevalence of Lambl's Excrescences using the Latest Three-dimensional Transesophageal Echocardiography. 20191200