ymizumi/published_papers/53743946 Yuki Yamasaki Kazuhiro Nomura Yuka Matsumoto Kana Fukuda-Takeji Yumiko Miyatake Naoya Suemasa Yuna Izumi-Mishima Sonoko Yasui-Yamada Masashi Kuroda Nagakatsu Harada Yasuo M Tsutsumi Tadahiro Kitamura Rie Tsutsumi Yutaka Nakaya Hiroshi Sakaue Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats. PURPOSE: Skeletal muscle atrophy is a critical complication of type 1 diabetes mellitus (T1DM), primarily caused by insulin deficiency. While physical activity is known to improve metabolic health, its effectiveness in preventing diabetes-induced muscle atrophy, particularly in the absence of insulin, remains unclear. This study examined the effects of voluntary exercise on muscle atrophy in an early phase streptozotocin (STZ)-induced diabetic rat model. METHODS: STZ was administered to male Wistar rats and SPORTS rats, which maintain high activity levels even after diabetes onset. Blood glucose levels, skeletal muscle mass, and muscle atrophy-related gene expression (Atrogin-1 and MuRF1) were measured, as well as locomotor activity. The effects of insulin, the sodium-glucose cotransporter (SGLT) inhibitor phlorizin, and leucine supplementation were also examined. RESULTS: Extensor digitorum longus (EDL) muscle mass decreased significantly within seven days of diabetes onset, accompanied by early expression of atrophy-related genes. Insulin administration prevented the decrease in EDL muscle mass, whereas phlorizin did not, despite improving hyperglycemia. SPORTS rats maintained high voluntary locomotor activity after diabetes onset but failed to prevent muscle atrophy. Metabolomic analysis indicated altered branched-chain amino acid (BCAA) metabolism in diabetic muscle tissue. Leucine supplementation partially attenuated muscle atrophy in STZ-treated diabetic rats. CONCLUSIONS: These findings suggest that insulin deficiency, rather than decreased physical activity, is a major contributor to early muscle atrophy in this model. Voluntary exercise alone is insufficient to prevent STZ-induced muscle atrophy in the absence of insulin. Leucine supplementation may offer a potential therapeutic strategy for muscle preservation. Biochemistry and biophysics reports 46 102627 102627 20260600 10.1016/j.bbrep.2026.102627 42164254 ymizumi/published_papers/53419594 Masashi Kuroda Kazuhiro Nomura Azumi Wada Yui Hatano Miki Ogawa Saya Okamoto Etsuko Ishikawa Yuna Izumi-Mishima Sonoko Yasui-Yamada Yasuo M Tsutsumi Nagakatsu Harada Rie Tsutsumi Hiroshi Sakaue Adipose tissue-derived MFG-E8 promotes hepatic inflammation and fibrosis through macrophage activation in a mouse MASH model. Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular injury, macrophage activation, and severe fibrosis, and often progresses to liver cirrhosis and hepatocellular carcinoma. Excessive accumulation of visceral fat exacerbates hepatic inflammation and fibrosis independently of fatty liver, but the underlying molecular mechanisms have remained unclear. We here identify MFG-E8 (milk fat globule-EGF8) as a secreted protein that is overexpressed in adipose tissue of obese mice and contributes to such exacerbation. MFG-E8 deficiency in MASH model (STAM-MASH) mice was associated with reduced hepatic expression of inflammation- and fibrosis-related genes without attenuation of steatosis. Conversely, MFG-E8 supplementation in MFG-E8 knockout mice intensified hepatic inflammation and promoted the formation of hepatic crownlike structures. Coculture of macrophages with apoptotic hepatocytes induced expression of inflammatory cytokine genes, and this effect was enhanced by the presence of exogenous MFG-E8 in the culture medium. Our findings suggest that adipose tissue-derived MFG-E8 infiltrates the liver and promotes macrophage-hepatocyte interaction, thereby contributing to hepatic inflammation and fibrosis in MASH. npj metabolic health and disease 4 1 null null 20260220 10.1038/s44324-026-00099-0 41720949 ymizumi/published_papers/53419596 Yuna Izumi-Mishima Kazuhiro Nomura Hiroshi Sakaue Sarcopenia and body temperature-the significance of interorgan metabolic networks in skeletal muscle atrophy. The skeletal muscle plays a key role in thermogenesis and energy homeostasis in endotherms. Therefore, reduced skeletal muscle mass and function are closely associated with health disorders such as obesity and hypothermia. In humans, inactivity and nutritional deficiencies can lead to skeletal muscle atrophy. However, hibernating mammals, which can greatly suppress their metabolic rate, can maintain significant skeletal muscle mass even during prolonged periods of inactivity and nutritional restriction. This review focuses on how skeletal muscle contributes to maintaining body temperature as the organ that consumes the most energy, while also contributing to whole-organism homeostasis through its high metabolic flexibility in a self-sacrificing manner. Particularly, we reconceptualized muscle atrophy associated with the thermoregulatory process in terms of inter-organ metabolic interaction, proposing that sarcopenia is an integral component of systemic energy metabolism regulation. By deepening our understanding of the functional metabolic flexibility of skeletal muscle and its regulatory mechanisms, we can redefine sarcopenia as an adaptive response that contributes to maintaining metabolic homeostasis. This perspective could provide new insights into the pathophysiology of sarcopenia and metabolic disorders, and inform the development of more effective prevention and treatment strategies. Endocrine journal 73 2 159 174 20260202 10.1507/endocrj.EJ25-0322 41407366 ymizumi/published_papers/53419595 Kazuhiro Nomura Sonoko Yasui-Yamada Yuna Izumi-Mishima Hiroshi Sakaue High prevalence of sleep apnea and its association with autonomic dysfunction in Non-obese individuals with diabetes. Endocrine 91 1 5 5 20251229 10.1007/s12020-025-04538-8 41460417 ymizumi/published_papers/51626452 Yuna Izumi-Mishima Rie Tsutsumi Tetsuya Shiuchi Saori Fujimoto Momoka Taniguchi Mizuki Sugiuchi Manaka Tsutsumi Yuko Okamatsu-Ogura Takeshi Yoneshiro Masashi Kuroda Kazuhiro Nomura Hiroshi Sakaue Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. Endotherms increase the rate of metabolism in metabolic organs as one strategy to cope with a decline in the temperature of the external environment. However, an additional major contributor to maintenance of body temperature in a cold environment is contraction-based thermogenesis in skeletal muscle. Here, we show that impairment of hind limb muscle contraction by cast immobilization induced a loss of function of skeletal muscle and activated brown adipose tissue (BAT) thermogenesis as a compensatory mechanism. BAT utilizes free branched-chain amino acids (BCAAs) derived from skeletal muscle as an energy substrate for thermogenesis, and interleukin-6 released by skeletal muscle stimulates BCAAs production in muscle for support of BAT thermogenesis. Additionally, this thermoregulatory system between BAT and skeletal muscle may also play an important role in response to cold temperatures or acute stress. Our findings suggest that BAT and skeletal muscle cooperate to maintain body temperature in endotherms. eLife 13 null null 20251027 10.7554/eLife.99982 41143503 ymizumi/published_papers/51428099 Hayato Tanabe Yoshinori Takiguchi Rie Tsutsumi Kaori Shiroma Mizusa Hyodo Yuna Izumi-Mishima Kazuhiro Nomura Masafumi Matsuo Hiroshi Sakaue Michio Shimabukuro Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study. OBJECTIVE: The predictive power of urinary titin for incident sarcopenia was studied in Japanese individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: Baseline urinary titin levels were measured, and sarcopenia was evaluated annually using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Kaplan-Meier curves, Cox models, and time-dependent receiver operating characteristic analyses were used to assess incident sarcopenia. RESULTS: Among 444 participants (median follow-up, 1,078 days), 41 developed sarcopenia. The high titin tertile was associated with an elevated sarcopenia risk (log-rank P = 0.04). Cox models associated titin with sarcopenia (adjusted hazard ratio per SD 1.37, 95% CI 1.05-1.77, P = 0.019) and low muscle strength. Risk estimates were consistent across subgroups, including those aged ≥70 years, men, individuals with BMI <25 kg/m2, HbA1c ≥7%, and estimated glomerular filtration rate ≥60 mL/min/1.73 m2 (P for interaction > 0.05). CONCLUSIONS: Elevated urinary titin levels predict sarcopenia and low muscle strength in individuals with type 2 diabetes, supporting its use as a noninvasive biomarker. Diabetes care 48 10 1844 1849 20251001 10.2337/dc25-1067 40854208 ymizumi/published_papers/50803533 Fumiko Shinkai-Ouchi Yoshiki Itoh Mayumi Shindo Kyohei Mikami Yoshinobu Iguchi Shoji Hata Rie Tsutsumi Yuna Izumi-Mishima Kyoka Machida Yuki Suzuki Hiroshi Sakaue Yasuko Ono Distinct systemic metabolic features in limb-girdle muscular dystrophy type R1 mouse models as a potential early pathogenic signature. Limb-girdle muscular dystrophy type R1 (LGMDR1, formerly LGMD2A) is a genetic disorder caused by mutations in CAPN3 and is characterized by progressive proximal limb muscle weakness. The CAPN3 gene product, calpain-3/CAPN3/p94, is a member of the intracellular cysteine protease superfamily predominantly expressed in the skeletal muscle. LGMDR1 pathogenesis has been investigated separately using mouse models: CAPN3:C129S [knock-in (KI)] mice, which express a proteolytically inactive variant, and CAPN3 knockout (KO) mice. These studies propose that CAPN3 bears both proteolytic activity-dependent and -independent functions and that the loss of either or both affects phenotypes. Here, we report a side-by-side, long-term analysis of KI and KO mice to comprehensively understand the LGMDR1 pathology in terms of CAPN3 function. Their physiques were comparable to those of wild-type animals, but age-dependent LGMDR1 symptoms were observed by histochemical analysis, with more severe symptoms observed in KO mice. Quantitative muscle proteomics and gene ontology analyses revealed more diverse changes in the KO mice than in the KI mice. Of the associated terms, "metabolic process" was the most affected across the genotype and age groups. Metabolomic analysis suggested that the skeletal muscles of these mice had an imbalance in the branched-chain amino acid catabolic pathway. Furthermore, a reduction in lipids and glycogen was observed in the liver of KO mice, suggesting that a systemic energy deficit occurs during CAPN3 deficiency. Altogether, our results suggest that muscular dysfunction in LGMDR1 models is associated with compromised systemic energy balance and that the extent of perturbation is implicated in disease severity. Biochimica et biophysica acta. Molecular basis of disease 1871 7 167983 167983 20251000 10.1016/j.bbadis.2025.167983 40645299 ymizumi/published_papers/50472224 Masashi Kuroda Kazuhiro Nomura Rin Chamoto Yuna Izumi-Mishima Sonoko Yasui-Yamada Yasuo M Tsutsumi Rie Tsutsumi Hiroshi Sakaue DNA methyltransferase inhibition by 5-azacytidine promotes thermogenic programming in beige adipocytes. Beige adipocytes play a critical role in energy metabolism by promoting thermogenesis, a process largely influenced by epigenetic modifications such as DNA methylation. This study investigates the effect of DNA demethylation on beige adipocyte differentiation and function using 5-azacytidine (5-AzaC), a DNA methyltransferase inhibitor. We evaluated changes in adipogenic and thermogenic gene expression, mitochondrial activity, and fatty acid uptake following 5-AzaC treatment in 3T3-L1-derived beige adipocytes. Our findings indicate that 5-AzaC does not significantly affect adipocyte differentiation but enhances thermogenic gene expression, including Ucp1 and Cox7a1, and increases mitochondrial function and fatty acid uptake. These results suggest that DNA demethylation modulates beige adipocyte function and may have implications for metabolic disorders such as obesity and type 2 diabetes. Biochemical and biophysical research communications 774 152094 152094 20250808 10.1016/j.bbrc.2025.152094 40441068 ymizumi/published_papers/50472223 Sonoko Yasui-Yamada Teruhiro Morishita Nobuhiko Umemoto Rie Tsutsumi Kazuyo Kohno Shunsuke Shiota Mina Shinohara Yuna Izumi-Mishima Kazuhiro Nomura Hiroshi Sakaue Eiji Takeda Daily Energy and Protein Intake Requirements to Prevent Body Weight Loss in Elderly Residents of Nursing Homes. Background Maintaining body weight is crucial for preserving the health of older adults. This study aimed to identify the daily energy and protein intake levels necessary to prevent body weight loss exceeding 1 kg over a six-month period among nursing home residents. Methodology A retrospective analysis was conducted on 101 residents aged ≥75 years. Data on body weight changes and dietary intake over a continuous six-month period were reviewed. The association between dietary intake and body weight loss greater than 1 kg was evaluated in 78 female residents. Results Among the 101 residents (23 males and 78 females; median age: 91 years (interquartile range (IQR) = 86-94); median body mass index (BMI): 21.3 kg/m² (IQR = 18.7-23.7)), 41% experienced a body weight loss of more than 1 kg over six months, despite receiving a median energy intake of 24.7 kcal/kg/day (IQR = 19.6-29.2) and a protein intake of 0.98 g/kg/day (IQR = 0.81-1.20). Multivariate logistic regression analysis adjusted for age and BMI in female residents revealed that an energy intake exceeding 30 kcal/kg/day was significantly associated with a reduced risk of body weight loss (odds ratio (OR) = 0.17, 95% confidence interval (CI) 0.04-0.68, p = 0.013), as was protein intake exceeding 1.2 g/kg/day (OR = 0.12, 95% CI = 0.03-0.49, p = 0.003). Conclusions To prevent body weight loss in elderly female nursing home residents, a daily intake of at least 30 kcal/kg/day of energy and 1.2 g/kg/day of protein is recommended. These findings highlight the importance of proactive nutritional management in long-term care facilities to support better health outcomes in this vulnerable population. Cureus 17 5 e83983 null 20250500 10.7759/cureus.83983 40510057 ymizumi/published_papers/50083349 Kazuhiro Nomura Yuki Yamasaki Kana Takeji Sachie Deha Kaho Yamashita Yuna Izumi-Mishima Sonoko Yasui-Yamada Masashi Kuroda Nagakatsu Harada Tadahiro Kitamura Yasuo M Tsutsumi Rie Tsutsumi Yutaka Nakaya Hiroshi Sakaue Gut-pancreas axis in the control of insulin secretion in streptozotocin-resistant rats. The Spontaneously Running Tokushima Shikoku (SPORTS) rat is characterized by hyperactive behavior but is also a potential model for studies of the role of the gut-pancreas axis in the regulation of insulin secretion. We here explored the role of ghrelin, a hormone associated with appetite regulation, in insulin dynamics within the context of streptozotocin (STZ) resistance in SPORTS rats. Comprehensive analyses-including histological examinations, gene expression profiling, and assessment of metabolic parameters-revealed that SPORTS rats are resistant to STZ-induced pancreatic injury and that, in addition to low circulating ghrelin levels, they manifest increased circulating levels of active glucagon-like peptide-1 (GLP-1) and upregulated expression of Pdx1 in the pancreas. Ghrelin administration attenuated the STZ resistance of these rats, with suppression of GLP-1 and downregulation of Pdx1 expression being implicated in this effect. Our results highlight the complex interplay among ghrelin, GLP-1, and insulin dynamics, and they suggest potential new therapeutic targets for diabetes. Biochemical and biophysical research communications 752 151487 151487 20250308 10.1016/j.bbrc.2025.151487 39955952 ymizumi/published_papers/50083348 Momoko Kyomen Ayako Tatsumi Rie Tsutsumi Yuna Izumi-Mishima Mizusa Hyodo Eiji Tanaka Kohta Iguchi Kojiro Taura Hiroaki Terajima Sachiko Honjo Akihiro Hamasaki Kazuhiro Nomura Hiroshi Sakaue Urinary Titin on the First Postoperative Day Predicts Long-Term Skeletal Muscle Loss in Patients with Gastroenterological Cancer. Perioperative malnutrition is common in patients with gastroenterological cancer and contributes to postoperative skeletal muscle atrophy, which adversely affects their prognosis. Early assessment of skeletal muscle atrophy is crucial for improving postoperative outcomes. This study aimed to evaluate the efficacy of urinary titin as a biomarker for skeletal muscle atrophy. A prospective observational study was conducted, and a total of 34 gastroenterological cancer patients were included. Urinary titin levels were measured using ELISA at admission, postoperative days (POD) 1, 7, and 14, and at 6 months after surgery. Surgical procedure, operative time, cancer stage, postoperative complications, hospital stay, and preoperative and postoperative body composition were evaluated, along with nutritional status and grip strength from admission to 6 months after surgery. Changes in urinary titin levels were measured at the same time points as described above. Preoperatively, the mean urinary titin level was 5.03 pmol/mg Cr, slightly higher than in healthy subjects. Urinary titin peaked at 33.71 (24.30-66.58) pmol/mg/dL Cr on POD1 and was associated with serum free branched-chain amino acid concentrations. Urinary titin on POD1 was significantly correlated with a decrease in skeletal muscle mass (rs -0.361, p = 0.036) and body cell mass (rs -0.361, p = 0.038) at 6 months postoperatively. The grip strength at 6 months postoperatively tended to decrease (rs -0.342, p = 0.052). BMI and serum LDH at admission were associated with urinary titin on POD1 but were not correlated with skeletal muscle loss at 6 months, suggesting that urinary titin on POD1 is an independent biomarker of skeletal muscle atrophy. These data indicate that urinary titin on POD1 can predict long-term skeletal muscle atrophy. International journal of molecular sciences 26 5 null null 20250226 10.3390/ijms26052026 40076646 ymizumi/published_papers/53419597 Ayako Tatsumi Momoko Kyomen Rie Tsutsumi Kana Beppu Rina Aihara-Matsushima Yuna Izumi-Mishima Sonoko Yasui-Yamada Yasuo M Tsutsumi Kazuhiro Nomura Hiroshi Sakaue Association of energy expenditure with body composition and nutritional intake in male patients with esophageal and head and neck cancer. Objective;In order to maintain a patient's adequate nutritional status, it is important to accurately assess energy expenditure and to provide nutritional administration commensurate with that expenditure. In this study, we have assessed the resting energy expenditures (REE) in patients with esophageal and head and neck cancer, and association between REE, metabolites, nutritional intake, and body composition. Methods;Patients included in the study had to be diagnosed with esophageal and head and neck cancer, and hospitalized and receiving chemotherapy. REE was measured using indirect calorimetry with a mask and calculated using 3 different equations. Result;Patients with esophageal and head and neck cancer (67.1±8.5 years old, n=52, all patients were male) were enrolled. The average of REE measured by indirect calorimetry were 22.1kcal/kg/day. REE was positively correlated with muscle mass, body cell mass, and lean body mass. REE was higher in group with oral intake of more than 72%. Blood levels of lactate, pyruvate, and amino acids were higher in cancer patients with esophageal and head and neck cancer compared to healthy subjects. Conclusion:REE measured by indirect calorimetry correlated with the estimated BEE. There was an association between energy expenditure and muscle mass and nutritional intake. J. Med. Invest. 72 : 252-259, August, 2025. The journal of medical investigation : JMI 72 3.4 252 259 20250000 10.2152/jmi.72.252 41183923 ymizumi/published_papers/50083350 Mizusa Hyodo Kazuhiro Nomura Rie Tsutsumi Yuna Izumi-Mishima Hibiki Kawaguchi Ayuka Kawakami Kanako Hara Yuki Suzuki Taku Shirakawa Kayo Osawa Masafumi Matsuo Hiroshi Sakaue Urinary titin as an early biomarker of skeletal muscle proteolysis and atrophy in various catabolic conditions. Skeletal muscle atrophy impairs quality of life and increases the risk of disease, but current methods for assessment of muscle mass have several limitations. We here investigated the urinary concentration of a fragment of the muscle protein titin as a potential biomarker for the early detection of skeletal muscle atrophy. Four mouse models with different atrophy pathways were studied: those of cardiotoxin-induced acute muscle injury, cast-induced muscle immobilization, lipopolysaccharide-induced sepsis, and streptozotocin-induced diabetes. In all four models, urinary titin levels increased early, concurrent with or preceding upregulation of the atrophy-related genes for atrogin-1 and MuRF-1. The increase in the urinary titin concentration was thus associated with initial muscle damage and the onset of proteolysis, rather than with late-stage muscle wasting. Our findings suggest that urinary titin is a promising biomarker for detection of the onset of skeletal muscle catabolism and prediction of the subsequent development of atrophy in different catabolic states. Noninvasive measurement of urinary titin may therefore allow the earlier detection of skeletal muscle proteolysis compared with conventional techniques. Biochemical and biophysical research communications 737 150918 150918 20241210 10.1016/j.bbrc.2024.150918 39488086 ymizumi/published_papers/50083351 Hiromi Matsuo Ryota Matsui Koshi Kumagai Satoshi Ida Yoko Saino Aya Fujiwara Kumi Takagi Yukiko Itami Misuzu Ishii Naoki Moriya Yuna Izumi-Mishima Kazuhiro Nomura Yasuo M Tsutsumi Souya Nunobe Rie Tsutsumi Hiroshi Sakaue Reply to Lee, S.Y. Comment on "Matsuo et al. Impact of Olfactory Change on Postoperative Body Weight Loss in Patients with Gastric Cancer after Gastrectomy. Nutrients 2024, 16, 851". Dr [...]. Nutrients 16 15 null null 20240726 10.3390/nu16152423 39125304 ymizumi/published_papers/46405222 Hiromi Matsuo Ryota Matsui Koshi Kumagai Satoshi Ida Yoko Saino Aya Fujihara Kumi Takagi Yukiko Itami Misuzu Ishii Naoki Moriya Yuna Izumi-Mishima Kazuhiro Nomura Yasuo M Tsutsumi Souya Nunobe Rie Tsutsumi Hiroshi Sakaue Impact of Olfactory Change on Postoperative Body Weight Loss in Patients with Gastric Cancer after Gastrectomy. Patients undergoing gastrectomy for gastric cancer may experience alterations in olfaction, yet the association between olfactory changes and postoperative weight loss remains uncertain. This study aimed to elucidate the relationship between olfactory changes and postoperative weight loss in patients with gastric cancer. Patients who underwent radical gastrectomy for gastric cancer between February 2022 and August 2022 were included in the study. Those experiencing a higher Visual Analog Scale (VAS) score postoperatively compared to preoperatively were deemed to have undergone olfactory changes. Postoperative weight loss was determined using the 75th percentile as a cutoff value, designating patients surpassing this threshold as experiencing significant weight loss. Multivariate logistic regression analysis was employed to identify risk factors for postoperative weight loss, with statistical significance set at p < 0.05. Out of 58 patients, 10 (17.2%) exhibited olfactory changes. The rate of postoperative weight loss at one month was markedly higher in the group with olfactory changes compared to those without (9.6% versus 6.2%, respectively; p = 0.002). In addition, the group experiencing olfactory changes demonstrated significantly lower energy intake compared to the group without such changes (1050 kcal versus 1250 kcal, respectively; p = 0.029). Logistic regression analysis revealed olfactory changes as an independent risk factor for significant weight loss at one month postoperatively (odds ratio: 7.64, 95% confidence interval: 1.09-71.85, p = 0.048). In conclusion, olfactory changes emerged as an independent risk factor for postoperative weight loss at one month in patients with gastric cancer following gastrectomy. Nutrients 16 6 null null 20240315 10.3390/nu16060851 38542761 ymizumi/published_papers/46405223 Takahiro Kato Satoshi Kamiya Soshi Narasaki Ayako Sumii Yasuo M Tsutsumi Kyoka Machida Kanako Hara Yuna Izumi-Mishima Rie Tsutsumi Hiroshi Sakaue Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice. Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber that is effective for defecation control. It influences the gut microbiota, by which it is metabolized to yield short-chain fatty acids (SCFAs), and it was also recently shown to protect against influenza infection in humans. We here investigated the effects of PHGG in a mouse model of influenza H1N1 virus infection. Eight-week-old C57BL/6 mice were fed normal chow with or without PHGG (500 mg/kg per day) for 4 weeks, infected with H1N1 at 10 weeks of age, and analyzed at 12 weeks of age. Administration of PHGG attenuated the decline in body weight induced by H1N1 infection without affecting food intake. It also ameliorated intestinal atrophy and increased the production of SCFAs including acetic acid, propionic acid, and butyric acid in the cecum, thereby preventing the inhibitory effect of H1N1 infection on SCFA production. The H1N1-induced increases in the serum concentrations of inflammatory cytokines including interferon-γ and interleukin-6 and anti-inflammatory cytokine such as interleukin-10 were all inhibited by PHGG intake. In addition, PHGG administration attenuated inflammatory gene expression in the lung and promoted both natural killer cell activity and regulatory T-cell differentiation in the spleen. Our findings suggest that the consumption of PHGG may improve the gut environment and thereby limit the inflammatory response to H1N1 infection. They may thus provide the basis for novel dietary intervention strategies to suppress the excessive inflammation associated with virus infection. Nutrients 15 19 null null 20231003 10.3390/nu15194252 37836536 ymizumi/published_papers/42366742 Ayuka Kawakami Mika Bando Tomoe Takashi Mizuki Sugiuchi Mizusa Hyodo Yuna Mishima Masashi Kuroda Hiroyasu Mori Akio Kuroda Hiromichi Yumoto Munehide Matsuhisa Hiroshi Sakaue Rie Tsutsumi Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes. OBJECTIVE: Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment. SUBJECTS AND METHODS: In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR. Food intake was evaluated using a food frequency questionnaire based on food groups. The oral environment was assessed using xerostomia and periodontal comprehensive examination. RESULTS: In total, 45.3%, 28.0%, and 18.7% of subjects showed lower umami taste sensitivity, low sweet taste sensitivity, and low salt taste sensitivity, respectively. Lower umami sensitivity correlated with lower estimated glomerular filtration rate and higher energy-source food intake. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression than those with lower plaque control record. CONCLUSION: Reduced umami taste sensitivity is associated with decreased renal function and high energy food intake in diabetes. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression, suggesting that the oral environment affects taste gene expression. J. Med. Invest. 70 : 241-250, February, 2023. The journal of medical investigation : JMI 70 1.2 241 250 20230000 10.2152/jmi.70.241 37164729 ymizumi/published_papers/42366743 Kana Beppu Ayuka Kawakami Yuna Mishima Rie Tsutsumi Masashi Kuroda Hiroyasu Mori Akio Kuroda Munehisa Matsuhisa Hiroshi Sakaue Taste receptor gene expression is associated with decreased eGFR in patients with diabetes. Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient's quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022. The journal of medical investigation : JMI 69 1.2 120 126 20220000 10.2152/jmi.69.120 35466133 ymizumi/published_papers/42366752 Mayu Sebe Rie Tsutsumi Satoka Senoura Jun Kishi Marina Iuchi Yuna Mishima Yasuo M. Tsutsumi Masashi Kuroda Nagakatsu Harada Yutaka Nakaya Seizo Kinoshita Yasuhiko Nishioka Hiroshi Sakaue Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis Wiley JCSM Rapid Communications 2617-1619 5 1 86 101 20211221 10.1002/rco2.53 ymizumi/published_papers/42366744 Rie Tsutsumi Yuki Yamasaki Jiro Takeo Hiroko Miyahara Mayu Sebe Masahiro Bando Yousuke Tanba Yuna Mishima Kana Takeji Nanako Ueshima Masashi Kuroda Saeko Masumoto Nagakatsu Harada Daiju Fukuda Ryoko Yoshimoto Yasuo M Tsutsumi Ken-Ichi Aihara Masataka Sata Hiroshi Sakaue Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora. Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE-/- mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease. Translational research : the journal of laboratory and clinical medicine 237 16 30 20211100 10.1016/j.trsl.2021.03.016 33775867 ymizumi/published_papers/42366745 Yumiko Miyatake Yuna Mishima Rie Tsutsumi Tamaki Otani Naoya Suemasa Saeko Masumoto Masashi Kuroda Hiroshi Sakaue Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging. Measuring glucose uptake in the skeletal muscle in vivo is an effective method to determine glucose metabolism abnormalities as the skeletal muscle is the principal tissue responsible for glucose disposal and is a major site of peripheral insulin resistance. In this study, we investigated the pathological glucose metabolism dynamics of the skeletal muscle of C57BL/6J mice in a noninvasive and time-sequential manner using positron emission tomography/computed tomography (PET/CT), an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body, with [18F]-fluoro-2-deoxy-D-glucose (FDG). FDG-PET/CT imaging revealed that insulin administration and exercise load significantly increased FDG accumulation in the skeletal muscle of C57BL/6J mice. FDG accumulation was lower in the skeletal muscle of 14-week-old db/db diabetic model mice exhibiting remarkable insulin resistance compared to that of 7-week-old db/db mice. Based on the continuous observation of FDG accumulation over time in diet-induced obese (DIO) mice, FDG accumulation significantly decreased in 17-week-old mice after the acquisition of insulin resistance. Although insulin-induced glucose uptake in the skeletal muscle was markedly attenuated in 20-week-old DIO mice that had already developed insulin resistance, exercise load effectively increased FDG uptake in the skeletal muscle. Thus, we successfully confirmed that glucose uptake accompanied by insulin administration and exercise load increased in the skeletal muscle using PET-CT. FDG-PET/CT might be an effective tool that could noninvasively capture the chronological changes of metabolic abnormalities in the skeletal muscle of mice. Biochemical and biophysical research communications 528 3 499 505 20200730 10.1016/j.bbrc.2020.05.165 32513534 ymizumi/misc/54658792 山田 苑子 重田 萌々花 和泉 優奈 阪上 浩 野村 和弘 【老年栄養エキスパートブック-マッスルヘルスからデジタルヘルスまで最新コンセンサスを読み解く】(Part2)体組成評価 BIVAの理解を深める測定原理と将来像 医歯薬出版(株) 臨床栄養 0485-1412 148 6 784 789 20260500 ymizumi/misc/54658797 山田 苑子 重田 萌々花 大内 彩矢 早川 あさ美 和泉 優奈 野村 和弘 阪上 浩 頭頸部がん化学放射線療法中の体組成および全身状態評価に対するBIVAの有用性 (一社)日本病態栄養学会 日本病態栄養学会誌 1345-8167 29 Suppl. S 49 20260100 ymizumi/misc/54658796 重田 萌々花 山田 苑子 大内 彩矢 早川 あさ美 和泉 優奈 田原 強 野村 和弘 阪上 浩 筋肉を標的とした生体電気インピーダンスベクトル分析による筋質評価の有用性 (一社)日本病態栄養学会 日本病態栄養学会誌 1345-8167 29 Suppl. S 66 20260100 ymizumi/misc/54658795 武田 英二 河野 和代 森下 照大 梅本 誠彦 浅野 有香 石田 純子 上田 育代 山田 苑子 和泉 優奈 堤 理恵 野村 和弘 阪上 浩 介護施設入所の後期高齢女性における体重減少リスクと栄養摂取量・体格指数の関連 (一社)日本病態栄養学会 日本病態栄養学会誌 1345-8167 29 Suppl. S 68 20260100 ymizumi/misc/54658794 京面 ももこ 巽 絢子 堤 理恵 和泉 優奈 兵藤 瑞紗 田中 英治 井口 公太 田浦 康二朗 寺嶋 宏明 本庶 祥子 濱崎 暁洋 野村 和弘 阪上 浩 周術期尿中タイチン濃度は術後骨格筋萎縮を予測する (一社)日本病態栄養学会 日本病態栄養学会誌 1345-8167 29 Suppl. S 82 20260100 ymizumi/misc/54658802 阪上 浩 黒田 雅士 和田 あずみ 和泉 優奈 山田 苑子 堤 理恵 野村 和弘 肥満症とMASLD 脂肪組織と肝臓の臓器間ネットワーク 脂肪組織由来MFG-E8は肝臓の炎症および線維化を促進する (一社)日本肥満学会 肥満研究 1343-229X 31 136 136 20251000 ymizumi/misc/54658801 野村 和弘 中尾 優花 黒田 雅士 和泉 優奈 山田 苑子 志内 哲也 堤 理恵 阪上 浩 脂肪細胞研究Up-to-date 新たなベージュ脂肪細胞制御機構の同定 (一社)日本肥満学会 肥満研究 1343-229X 31 189 189 20251000 ymizumi/misc/54658800 山崎 幸 野村 和弘 竹治 香菜 出葉 祥恵 山下 果穂 和泉 優奈 山田 苑子 北村 忠弘 堤 理恵 阪上 浩 臓器連関による代謝調節 消化管ホルモン連関による膵β細胞保護機構 グレリンとGLP-1のPdx1制御を介した役割 (一社)日本肥満学会 肥満研究 1343-229X 31 243 243 20251000 ymizumi/misc/54658799 和泉 優奈 野村 和弘 堤 真花 志内 哲也 藤本 紗織 杉内 美月 大村 皐月 谷口 萌々花 山田 苑子 岡松 優子 米代 武司 黒田 理恵 堤 理恵 阪上 浩 臓器連関による代謝調節 骨格筋と褐色脂肪組織の臓器連関による体温・代謝調節機構 (一社)日本肥満学会 肥満研究 1343-229X 31 245 245 20251000 ymizumi/misc/54658798 堤 真花 和泉 優奈 杉内 美月 山田 苑子 堤 理恵 志内 哲也 岡松 優子 米代 武司 阪上 浩 野村 和弘 体温・代謝調節における骨格筋由来IL-6発現調節メカニズムの解明 (一社)日本肥満学会 肥満研究 1343-229X 31 408 408 20251000 ymizumi/misc/54658803 山田 苑子 重田 萌々花 和泉 優奈 野村 和弘 阪上 浩 神村 盛一郎 北村 嘉章 頭頸部がん化学放射線療法における生体電気インピーダンスベクトル解析の有用性の検討 徳島医学会 四国医学雑誌 2758-3279 81 1-2 83 83 20250600 ymizumi/misc/54658808 山田 苑子 重田 萌々花 和泉 優奈 野村 和弘 阪上 浩 マウス腓腹筋の体組成と水分変化を捉える生体電気インピーダンスベクトル分析の意義 (公社)日本栄養・食糧学会 日本栄養・食糧学会大会講演要旨集 79 214 214 20250400 ymizumi/misc/54658807 堤 真花 和泉 優奈 杉内 美月 山田 苑子 志内 哲也 岡松 優子 米代 武司 堤 理恵 野村 和弘 阪上 浩 臓器間アミノ酸代謝連関の制御因子としての骨格筋由来IL-6発現メカニズムの解明 (一社)日本糖尿病学会 糖尿病 1881-588X 68 Suppl. S 188 20250400 ymizumi/misc/54658806 中尾 優花 野村 和弘 黒田 雅士 和泉 優奈 山田 苑子 志内 哲也 堤 理恵 阪上 浩 転写因子IRF7によるベージュ脂肪細胞制御機構の解明 (一社)日本糖尿病学会 糖尿病 1881-588X 68 Suppl. S 189 20250400 ymizumi/misc/54658805 伊美 友紀子 天野 礼菜 生天目 侑子 和泉 優奈 笠原 南々帆 細川 友誠 今森 真 内田 邦敏 村上 光 原 雄二 阪上 浩 北村 忠弘 春日 雅人 小川 渉 細岡 哲也 褐色脂肪組織のPDK1はコハク酸の制御により褐色脂肪組織機能調節に重要な役割を担う (一社)日本糖尿病学会 糖尿病 1881-588X 68 Suppl. S 190 20250400 ymizumi/misc/54658804 和泉 優奈 大舘 衿奈 鈴木 由紀 村上 遥音 松尾 雅文 山田 苑子 野村 和弘 阪上 浩 ステロイド誘発性筋萎縮におけるミオスタチン標的アンチセンス核酸の効果 (一社)日本糖尿病学会 糖尿病 1881-588X 68 Suppl. S 289 20250400 ymizumi/misc/54658793 山田 苑子 重田 萌々花 難波 由佳里 梅本 誠彦 和泉 優奈 堤 理恵 野村 和弘 阪上 浩 武田 英二 在宅医療 介護施設入所中の後期高齢女性における体重減少予防に必要な栄養摂取量の検討 (一社)日本栄養治療学会 学会誌JSPEN 2434-4966 7 Suppl.2 285 285 20250000 ymizumi/misc/50096185 山田苑子 重田萌々花 和泉優奈 神村盛一郎 野村和弘 北村嘉章 阪上浩 頭頸部がん化学放射線療法における生体電気インピーダンスベクトル解析の有用性の検討 日本病態栄養学会誌(Web) 1345-8167 28 Supplement null null 20250000 ymizumi/misc/50096184 天野礼菜 伊美友紀子 生天目侑子 和泉優奈 笠原南々帆 細川友誠 今森真 内田邦敏 村上光 原雄二 阪上浩 北村忠弘 春日雅人 小川渉 細岡哲也 細岡哲也 褐色脂肪組織におけるPDK1はコハク酸の制御により褐色脂肪組織熱産生を調節する 日本病態栄養学会誌(Web) 1345-8167 28 Supplement null null 20250000 ymizumi/misc/50096193 山田苑子 久保みゆ 和泉優奈 野村和弘 神村盛一郎 柏原秀也 齋藤裕 北村嘉章 島田光生 浜田康弘 阪上浩 簡便に得られるデータから作成した四肢骨格筋量を予測する回帰式の妥当性検証 日本病態栄養学会誌(Web) 1345-8167 27 Supplement null null 20240000 ymizumi/misc/54658809 和泉 優奈 大村 皐月 山田 苑子 志内 哲也 岡松 優子 米代 武司 野村 和弘 堤 理恵 阪上 浩 骨格筋-BAT間アミノ酸代謝連関に対する制御機構の解明 (一社)日本肥満学会 肥満研究 1343-229X 29 289 289 20231100 ymizumi/misc/50096221 天野礼菜 伊美友紀子 伊美友紀子 笠原南々帆 生天目侑子 黒田雅士 三島優奈 細川友誠 今森真 内田邦敏 村上光 原雄二 阪上浩 北村忠弘 春日雅人 小川渉 細岡哲也 細岡哲也 細岡哲也 褐色脂肪組織におけるインスリンシグナル鍵キナーゼPDK1の生理的役割とメカニズムの解明 日本栄養・食糧学会大会講演要旨集 77th null null 20230000 ymizumi/misc/50096217 田中杏奈 堤理恵 山本菜帆 三島優奈 黒田雅士 阪上浩 阪上浩 高脂肪食が記憶学習能力に与える影響とそのメカニズムの解明 四国医学雑誌(Web) 2758-3279 79 1-2 null null 20230000 ymizumi/misc/50096194 天野礼菜 伊美友紀子 伊美友紀子 笠原南々帆 生天目侑子 和泉優奈 細川友誠 今森真 内田邦敏 村上光 原雄二 阪上浩 北村忠弘 春日雅人 小川渉 細岡哲也 細岡哲也 細岡哲也 褐色脂肪組織におけるインスリンシグナル鍵キナーゼPDK1はコハク酸の産生調節を介して褐色脂肪組織熱産生を制御する 日本栄養・食糧学会中部支部大会講演要旨集 82nd null null 20230000 ymizumi/misc/50096192 村上遥音 和泉優奈 鈴木由紀 山田苑子 野村和弘 堤理恵 阪上浩 阪上浩 廃用性筋萎縮の骨格筋代謝動態に対するMCT配合ケトン食の影響 日本栄養・食糧学会中国・四国支部大会講演要旨集(CD-ROM) 56th null null 20230000 ymizumi/misc/50096191 藤田めい 和泉優奈 黒田雅士 山田苑子 堤理恵 野村和弘 阪上浩 阪上浩 肥満関連筋萎縮における転写因子Interferon Regulatory Factor 7(IRF7)の役割 日本栄養・食糧学会中国・四国支部大会講演要旨集(CD-ROM) 56th null null 20230000 ymizumi/misc/50096190 尾形優奈 新居美香 新居美香 堤理恵 松原由依 和泉優奈 山田苑子 野村和弘 阪上浩 阪上浩 香酸柑橘「阿波すず香」の抗肥満効果に関する研究 日本栄養・食糧学会中国・四国支部大会講演要旨集(CD-ROM) 56th null null 20230000 ymizumi/misc/50096188 大村皐月 和泉優奈 野村和弘 山田苑子 志内哲也 岡松優子 米代武司 堤理恵 阪上浩 阪上浩 臓器間アミノ酸代謝連関の調節因子としての骨格筋由来IL-6発現メカニズムの解明 日本栄養・食糧学会中国・四国支部大会講演要旨集(CD-ROM) 56th null null 20230000 ymizumi/misc/50096187 兵藤瑞紗 堤理恵 中西信人 大藤純 鈴木由紀 待田京香 原加奈子 和泉優奈 松尾雅文 阪上浩 骨格筋萎縮のバイオマーカーとしての尿中タイチン測定の有用性 日本筋学会学術集会プログラム・抄録集 2433-975X 9th null null 20230000 ymizumi/misc/50096186 和泉優奈 藤本紗織 谷口萌々花 大村皐月 志内哲也 岡松優子 米代武司 野村和弘 堤理恵 阪上浩 阪上浩 骨格筋による新たな体温維持機構の発見とその制御分子の同定 日本筋学会学術集会プログラム・抄録集 2433-975X 9th null null 20230000 ymizumi/misc/50096230 待田京香 堤理恵 原加奈子 三島優奈 藤本紗織 黒田雅士 中西信人 阪上浩 重症病態の骨格筋萎縮に認められた血中アミノ酸変動の意義 日本病態栄養学会誌(Web) 1345-8167 24/25 Supplement null null 20220000 ymizumi/misc/50096225 三島優奈 堤理恵 藤本紗織 志内哲也 岡松優子 黒田雅士 阪上浩 阪上浩 骨格筋不動化モデルにおける体温維持機構の解明 糖尿病(Web) 1881-588X 65 Suppl null null 20220000 ymizumi/misc/50096224 田中杏奈 堤理恵 中川琴海 三島優奈 黒田雅士 阪上浩 阪上浩 高脂肪食が脳機能に与える影響とそのメカニズムの解明 糖尿病(Web) 1881-588X 65 Suppl null null 20220000 ymizumi/misc/50096223 藤本紗織 堤理恵 三島優奈 志内哲也 岡松優子 黒田雅士 阪上浩 阪上浩 廃用性筋萎縮モデルにおける多臓器代謝動態の連関の意義 糖尿病(Web) 1881-588X 65 Suppl null null 20220000 ymizumi/misc/50096222 米田祥広 堤理恵 植松美侑 三島優奈 黒田雅士 阪上浩 阪上浩 極長鎖一価不飽和脂肪酸はEPAの抗動脈硬化作用を増強させる 糖尿病(Web) 1881-588X 65 Suppl null null 20220000 ymizumi/misc/50096220 鈴木由紀 堤理恵 待田京香 三島優奈 黒田雅士 大藤純 阪上浩 重症病態におけるエネルギー代謝抑制機構の解明 日本内分泌学会四国支部会学術集会プログラム・抄録集(Web) 22nd null null 20220000 ymizumi/misc/50096219 田中杏奈 堤理恵 山本菜帆 三島優奈 黒田雅士 阪上浩 阪上浩 高脂肪食が記憶学習能力に与える影響とそのメカニズムの解明 日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集 43rd-40th (Web) null null 20220000 ymizumi/misc/50096218 三島優奈 堤理恵 藤本紗織 谷口萌々花 志内哲也 岡松優子 米代武司 黒田雅士 阪上浩 阪上浩 体温維持における骨格筋の役割と臓器間代謝ネットワークの解明 日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集 43rd-40th (Web) null null 20220000 ymizumi/misc/50096233 三島優奈 堤理恵 大谷環樹 原加奈子 藤本紗織 黒田雅士 阪上浩 阪上浩 PET/CTを用いたマウス骨格筋インスリン抵抗性の評価 日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集 41st-38th (Web) null null 20210000 ymizumi/misc/50096231 米田祥広 堤理恵 三島優奈 黒田雅士 板東正浩 阪上浩 阪上浩 福田大受 佐田正隆 粟飯原賢一 粟飯原賢一 極長鎖一価不飽和脂肪酸は腸内細菌叢の変化を介して血管内皮機能を改善する 四国医学雑誌 0037-3699 77 5-6 null null 20210000 ymizumi/misc/50096226 堤理恵 待田京香 原加奈子 三島優奈 黒田雅士 阪上浩 グアーガム加水分解物のインフルエンザウイルスによる炎症と体重減少の抑制効果に関する検討 学会誌JSPEN(Web) 2434-4966 3 Supplement 1 null null 20210000 ymizumi/misc/42366881 待田京香 堤理恵 原加奈子 三島優奈 巽絢子 京面ももこ 筑後桃子 田尻真梨 山田静恵 鈴木佳子 黒田雅士 阪上浩 阪上浩 PHGG(グァーガム加水分解物)の炎症抑制および感染症予防の可能性の探索-基礎的・臨床的意義の検討 医歯薬出版 臨床栄養 0485-1412 139 5 730 736 20211000 1520856671817267456 ymizumi/misc/42366876 堤理恵 三島優奈 川上歩花 黒田雅士 阪上浩 Nutrition in metabolic syndrome-with recent topics- 生活習慣病を克服して,健康寿命を延伸するために 生活習慣病と栄養学~最近のトピックスを交えて~ Metabolic syndrome is a pathological condition with hyperglycemia, dyslipidemia, or hypertension resulting in cardiovascular and cerebrovascular disease. Factors that affect visceral fat accumulation and weight gain include not only physiological factors such as heredity, constitution, and age, but also behavioral factors and environmental factors. Eating behavior and eating environment are critical for the prevention and treatment of metabolic syndrome. In this report, we will discuss about recent topics of nutrition in metabolic syndrome, especially association with macronutrients such as carbohydrate, fatty acids and protein. In recent years, several publications have determined the benefit of low carbohydrate diet on obesity and diabetes, and the American Diabetes Association has also recommended low carbohydrate diet, Mediterranean diet, and a diet mainly consistent with vegetables and plants. There have been many reports that the effect of carbohydrate restriction has not only the weight loss effect but also reduces risk factors such as cardiovascular disease and cerebrovascular disease. Fanelli et al . recently have shown that half of US adults with diabetes have less than the recommended daily intake of protein, which may lead to poor dietary quality. Diabetic patients with low protein intake had significantly lower dietary nutrient density and 12．5% higher carbohydrate intake, whereas diabetic patients with daily protein intake meeting the recommended amount have shown that the overall quality of the diet was high and almost met the recommended daily amount of vegetables, whole grains, dairy products and added sugars. Therefore, in addition to the prevention of metabolic syndrome, protein is important for treatment of metabolic syndrome and higher QOL. Nutritional research needs further development to deal with metabolic syndrome. 徳島医学会 四国医学雑誌 0037-3699 77 5-6 187 192 20211225 1050292251404941184 ymizumi/misc/42366878 三島 優奈 堤 理恵 阪上 浩 代謝動態の連関による生体機能制御 : 骨格筋と代謝調節に注目して—Regulation of biological function by organ communication 科学評論社 糖尿病・内分泌代謝科 = Diabetology, endocrinology & metabolology / 糖尿病・内分泌代謝科編集委員会 編 2435-1946 51 1 71 77 20200700 1520010380610834688 ymizumi/misc/50096235 原加奈子 堤理恵 三島優奈 待田京香 阪上浩 中西信人 大藤純 重症患者における筋萎縮と尿中タイチン濃度に関する検討 四国医学雑誌 0037-3699 76 5-6 null null 20200000 ymizumi/misc/50096234 三島優奈 堤理恵 黒田雅士 阪上浩 大谷環樹 阪上浩 PET/CTを用いたマウス骨格筋インスリン抵抗性の評価 四国医学雑誌 0037-3699 76 5-6 null null 20200000 ymizumi/misc/50096232 三島優奈 堤理恵 松本裕華 原加奈子 大谷環樹 上嶋菜々子 神田彩恵 黒田雅士 阪上浩 廃用性筋萎縮モデルにおける骨格筋・肝代謝動態の連関による生体機能制御 日本病態栄養学会誌(Web) 1345-8167 23 Supplement null null 20200000 ymizumi/misc/50096228 神田彩恵 堤理恵 三島優奈 上嶋奈々子 松本裕華 原加奈子 黒田雅士 阪上浩 ロイシンの抗動脈硬化作用の検討 糖尿病(Web) 1881-588X 63 9 null null 20200000 ymizumi/misc/50096227 原加奈子 堤理恵 三島優奈 松本裕華 黒田雅士 大谷環樹 阪上浩 PET/CTを用いた代謝性疾患モデルマウス骨格筋糖取り込みの評価 糖尿病(Web) 1881-588X 63 9 null null 20200000 ymizumi/misc/42366880 原加奈子 堤理恵 中西信人 三島優奈 待田京香 黒田雅士 大藤純 阪上浩 Urinary titin reflects muscle atrophy in critical ill patients 重症患者における筋萎縮と尿中タイチン濃度測定の意義 Skeletal muscle atrophy is a serious problem in critically ill patients. After intensive care unit (ICU)admission, muscle atrophy starts within 3 days and progressively worsens thereafter. We have previously reported that upper and lower limb muscle mass of critically ill patients decreased by 13%‐21% within 7 days of admission. Muscle atrophy in the ICU is associated with long-term functional impairment and weakness in ICU survivors. Although monitoring of muscle mass is important, there have been no reliable biomarkers associated with muscle atrophy in critically ill patients. In this study, we have focused on urinary titin, which is the biggest giant sarcomere protein and functions as a spring for muscle extension and viscoelasticity. We have clarified that urinary titin level reflected muscle breakdown correlated with limb muscle atrophy in non-surgical critically ill patients. The cumulative urinary titin level associated with the incidence of ICU-AW and ICU mortality. Our study indicates urinary titin can be the noble biomarker to evaluate the catabolism and muscle atrophy in critically ill patients. 徳島医学会 四国医学雑誌 0037-3699 76 5-6 267 272 20201225 1050287363395004928 ymizumi/misc/42366875 三島 優奈 堤 理恵 阪上 浩 侵襲時のオートファジー制御とn‐3系脂肪酸投与 日本外科代謝栄養学会 外科と代謝・栄養 2187-5154 53 6 281 286 20191215 10.11638/jssmn.53.6_281 1390846609793694208 ymizumi/misc/42366877 三島 優奈 堤 理恵 阪上 浩 サルコペニア対策としての高蛋白食・アミノ酸製剤の効果—Benefit of high-protein diet or amino acid preparation for sarcopenia 科学評論社 内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism / 内分泌・糖尿病・代謝内科編集委員会 編 1884-2917 48 6 470 475 20190600 1522262179727006720 ymizumi/misc/42366879 黒田 雅士 三島 優奈 阪上 浩 ADCY3遺伝子異常と肥満—ADCY3 gene and Obesity 科学評論社 内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism / 内分泌・糖尿病・代謝内科編集委員会 編 1884-2917 48 3 214 218 20190300 1521417755406689664 ymizumi/misc/50096229 三島優奈 堤理恵 宮武由実子 末政直哉 大谷環樹 児玉直子 丹波洋介 黒田雅士 升本早枝子 阪上浩 PET/CTを用いた代謝異常時の骨格筋における糖取り込みの測定 糖尿病(Web) 1881-588X 62 Suppl null null 20190000 和泉 優奈 日本糖尿病学会 第16回 若手研究奨励賞(YIA) 20260500 和泉 優奈 徳島大学医学部 令和7年度 岡奨学賞 20260200 和泉 優奈 日本筋学会 Young Investigator's Award (YIA) 優秀賞 20230800 和泉 優奈 アディポサイエンス・シンポジウム 若手優秀研究賞 20230200 和泉 優奈 日本肥満学会 若手研究奨励賞(YIA) 20221200